Information on EC 3.6.1.19 - nucleoside-triphosphate diphosphatase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.6.1.19
deleted, now included in EC 3.6.1.9
RECOMMENDED NAME
GeneOntology No.
nucleoside-triphosphate diphosphatase
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
94 - 1100
5-methyl-CTP
206953
93 - 570
5-methyl-UTP
206952
19
8-oxo-GTP
Homo sapiens
-
wild type enzyme, at 37°C, pH not specified in the publication
8390
17 - 280
CTP
60
13
dCTP
Homo sapiens
-
wild type enzyme, at 37°C, pH not specified in the publication
179
41.5 - 6100
dITP
2839
21 - 290
dTTP
145
27.2 - 417
ITP
229
130 - 1300
pseudo-UTP
206954
17 - 220
UTP
65
13.1 - 270
XTP
1941
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
addition of extracellular ATP upregulates expression of ecto-nucleoside triphosphate diphosphohydrolase 2 and ecto-5'-nucleotidase
-
dogs infected with Rangelia vitalii had a reduction in the hydrolysis of ATP and ADP in platelets at day 12 post infection due to a reduced expression of the enzyme
-
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