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phenylacetonitrile + 2 H2O
phenylacetate + NH3
-
-
-
?
(3S)-isobutylsuccinonitrile + H2O
(3S)-3-cyano-5-methyl hexanoic acid
-
specific for the (3S)-isomer
-
-
?
(methylthio)acetonitrile + H2O
(methylthio)acetic acid + NH3
-
-
-
?
(methylthio)acetonitrile + H2O
2-(methylthio)acetic acid + NH3
-
-
-
?
(phenylthio)acetonitrile + H2O
2-(phenylthio)acetic acid + NH3
-
-
-
?
1-(cyanoacetyl)pyrrolidine + H2O
? + NH3
low activity
-
-
?
2-cyanopyridine + 2 H2O
pyridine 2-carboxylic acid + NH3
low activity
-
-
?
3-cyanopyridine + 2 H2O
pyridine 3-carboxylic acid + NH3
low activity
-
-
?
3-hydroxypropionitrile + H2O
3-hydroxypropanoate + NH3
3-phenylpropanenitrile + H2O
phenylacetic acid + NH3
-
-
-
-
?
3-phenylpropionitrile + H2O
3-phenylpropionic acid + NH3
the enzyme has 270times more activity with 3-phenylpropionitrile than that observed with benzonitrile
-
-
?
3-trans-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]prop-2-enenitrile + H2O
(2E)-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dien-1-yl]prop-2-enoic acid + NH3
-
-
-
-
?
4-hydroxybenzylcyanide + H2O
4-hydroxybenzoic acid + NH3
low activity
-
-
?
4-phenylbutyronitrile + H2O
4-phenylbutyric acid + NH3
-
-
-
?
allyl cyanide + H2O
prop-2-enoic acid + NH3
benzonitrile + 2 H2O
benzoic acid + NH3
-
-
-
?
chloroacetonitrile + H2O
chloroacetic acid + NH3
low activity
-
-
?
cyclopropanecarbonitrile + H2O
cyclopropanecarboxylic acid + NH3
-
-
-
?
hydrocinnamonitrile + H2O
hydrocinnamic acid + NH3
-
-
-
-
?
indol-3-acetonitrile + H2O
indol-3-acetic acid + NH3
indole-3-acetonitrile + H2O
indole-3-acetic acid + NH3
phenylacetonitrile + 2 H2O
phenylacetic acid + NH3
low activity
-
-
?
phenylbutyronitrile + H2O
phenylbutyric acid + NH3
phenylpropionitrile + 2 H2O
phenylpropionic acid + NH3
propionitrile + H2O
propionic acid + NH3
trans-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]-acrylonitrile + H2O
trans-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]-acrylic acid + NH3
-
-
-
-
?
additional information
?
-
3-hydroxypropionitrile + H2O
3-hydroxypropanoate + NH3
very low activity
-
-
?
3-hydroxypropionitrile + H2O
3-hydroxypropanoate + NH3
low activity
-
-
?
allyl cyanide + H2O
prop-2-enoic acid + NH3
-
-
-
?
allyl cyanide + H2O
prop-2-enoic acid + NH3
high activity
-
-
?
indol-3-acetonitrile + H2O
indol-3-acetic acid + NH3
-
-
-
?
indol-3-acetonitrile + H2O
indol-3-acetic acid + NH3
-
-
-
?
indol-3-acetonitrile + H2O
indol-3-acetic acid + NH3
-
-
-
?
indole-3-acetonitrile + H2O
indole-3-acetic acid + NH3
-
-
-
-
?
indole-3-acetonitrile + H2O
indole-3-acetic acid + NH3
low activity
-
-
?
indole-3-acetonitrile + H2O
indole-3-acetic acid + NH3
-
isozymes are involved in indole-3-acetic acid production
-
-
?
phenylbutyronitrile + H2O
phenylbutyric acid + NH3
-
-
-
?
phenylbutyronitrile + H2O
phenylbutyric acid + NH3
high activity
-
-
?
phenylpropionitrile + 2 H2O
phenylpropionic acid + NH3
-
-
-
?
phenylpropionitrile + 2 H2O
phenylpropionic acid + NH3
best substrate
-
-
?
propionitrile + H2O
propionic acid + NH3
-
-
-
?
propionitrile + H2O
propionic acid + NH3
low activity
-
-
?
additional information
?
-
broad substrate specificity, overview
-
-
?
additional information
?
-
broad substrate specificity, overview
-
-
?
additional information
?
-
broad substrate specificity, overview
-
-
?
additional information
?
-
-
broad substrate specificity, overview
-
-
?
additional information
?
-
isozyme NIT2 might be involved in supplying indole-3-acetic acid during seed development rather than during stratification
-
-
?
additional information
?
-
isozyme NIT2 might be involved in supplying indole-3-acetic acid during seed development rather than during stratification
-
-
?
additional information
?
-
isozyme NIT2 might be involved in supplying indole-3-acetic acid during seed development rather than during stratification
-
-
?
additional information
?
-
-
isozyme NIT2 might be involved in supplying indole-3-acetic acid during seed development rather than during stratification
-
-
?
additional information
?
-
-
does not convert cis-5,6-dihydroxy-cyclohexa-1,3-diene-1-carbonitrile
-
-
?
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Grsic-Rausch, S.; Kobelt, P.; Siemens, J.M.; Bischoff, M.; Ludwig-Muller, J.
Expression and localization of nitrilase during symptom development of the clubroot disease in Arabidopsis
Plant Physiol.
122
369-378
2000
Arabidopsis thaliana
brenda
Bartling, D.; Seedorf, M.; Schmidt, R.C.; Weiler, E.W.
Molecular characterization of two cloned nitrilases from Arabidopsis thaliana: Key enzymes in biosynthesis of the plant hormone indole-3-acetic acid
Proc. Natl. Acad. Sci. USA
91
6021-6025
1994
Arabidopsis thaliana
brenda
Bartling, D.; Seedorf, M.; Mithfer, A.; Weiler, E.W.
Cloning and expression of an Arabidopsis nitrilase which can convert indole-3-acetonitrile to the plant hormone, indole-3-acetic acid
Eur. J. Biochem.
205
417-424
1992
Arabidopsis thaliana
brenda
O'Reilly, C.; Turner, P.D.
The nitrilase family of CN hydrolyzing enzymes - a comparative study
J. Appl. Microbiol.
95
1161-1174
2003
Acidovorax facilis, Acidovorax facilis 72W, Acinetobacter sp., Acinetobacter sp. AK226, Aeribacillus pallidus, Aeribacillus pallidus Dac521, Alcaligenes faecalis, Alcaligenes faecalis JM3, Arabidopsis thaliana, Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) OxB-1, Brassica rapa, Comamonas testosteroni, Fusarium oxysporum, Fusarium solani, Fusarium solani IMI196840, Hordeum vulgare, Klebsiella pneumoniae, Nocardia sp., Pseudomonas sp., Rhodococcus rhodochrous, Rhodococcus rhodochrous K22, Rhodococcus sp., Rhodococcus sp. ATCC 39484
brenda
Brenner, C.
Catalysis in the nitrilase superfamily
Curr. Opin. Struct. Biol.
12
775-782
2002
Arabidopsis thaliana (P32961), Homo sapiens (Q86X76)
brenda
Vorwerk, S.; Biernacki, S.; Hillebrand, H.; Janzik, I.; Muller, A.; Weiler, E.W.; Piotrowski, M.
Enzymatic characterization of the recombinant Arabidopsis thaliana nitrilase subfamily encoded by the NIT2/NIT1/NIT3-gene cluster
Planta
212
508-516
2001
Arabidopsis thaliana (P32961), Arabidopsis thaliana (P32962), Arabidopsis thaliana (P46010), Arabidopsis thaliana
brenda
Yildirim, S.; Ruinatscha, R.; Gross, R.; Wohlgemuth, R.; Kohler, H.E.; Witholt, B.; Schmid, A.
Selective hydrolysis of the nitrile group of cis-dihydrodiols from aromatic nitriles
J. Mol. Catal. B
38
76-83
2006
Arabidopsis thaliana, Rhodococcus sp.
-
brenda
Dixon, D.P.; Skipsey, M.; Grundy, N.M.; Edwards, R.
Stress-induced protein S-glutathionylation in Arabidopsis
Plant Physiol.
138
2233-2244
2005
Arabidopsis thaliana (P32961)
brenda
Singh, R.; Sharma, R.; Tewari, N.; Tewari, N.; Rawat, D.S.
Nitrilase and its application as a green catalyst
Chem. Biodivers.
3
1279-1287
2006
Acidovorax facilis, Acidovorax facilis 72W, Acinetobacter sp., Acinetobacter sp. AK226, Aeribacillus pallidus, Aeribacillus pallidus Dac521, Alcaligenes faecalis, Arabidopsis thaliana, Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) OxB-1, Comamonas testosteroni, Fusarium oxysporum, Fusarium solani, Fusarium solani IMI196840, Hordeum vulgare, Klebsiella pneumoniae, Penicillium multicolor, Pseudomonas sp., Rhodococcus rhodochrous, Rhodococcus rhodochrous K22, Rhodococcus sp.
brenda
Yazbeck, D.R.; Durao, P.J.; Xie, Z.; Tao, J.
A metal ion-based method for the screening of nitrilases
J. Mol. Catal. B
39
156-159
2006
Arabidopsis thaliana
-
brenda
Xie, Z.; Feng, J.; Garcia, E.; Bernett, M.; Yazbeck, D.; Tao, J.
Cloning and optimization of a nitrilase for the synthesis of (3S)-3-cyano-5-methyl hexanoic acid
J. Mol. Catal. B
41
75-80
2006
Arabidopsis thaliana
-
brenda
Thuku, R.; Brady, D.; Benedik, M.; Sewell, B.
Microbial nitrilases: Versatile, spiral forming, industrial enzymes
J. Appl. Microbiol.
106
703-727
2009
Aeribacillus pallidus (Q0PIV8), Aeribacillus pallidus Dac521 (Q0PIV8), Arabidopsis thaliana (P32961), Arthrobacter sp., Aspergillus niger (A9QXE0), Aspergillus niger K10 (A9QXE0), Bradyrhizobium japonicum, Bradyrhizobium japonicum USDA 110, Brassica napus, Fusarium oxysporum f. sp. melonis, Fusarium solani, Fusarium solani IMI 196840, Fusarium solani O1, Rhodococcus rhodochrous, Rhodococcus rhodochrous ATCC 39484, Rhodococcus rhodochrous PA-34, Rhodococcus sp., Rhodococcus sp. NCIMB 11215, Rhodococcus sp. NCIMB 11216
brenda
Jez, J.
Plant nitrilase A new job for an old enzyme
Biochem. J.
476
1105-1107
2019
Arabidopsis thaliana (P32961), Arabidopsis thaliana
brenda
Sharma, N.; Verma, R.; Savitri, R.; Bhalla, T.C.
Classifying nitrilases as aliphatic and aromatic using machine learning technique
3 Biotech
8
68
2018
Aeribacillus pallidus, Arabidopsis thaliana (P46010), Arenibacter latericius, Bacillus sp. OxB-1 (P82605), Blastomyces dermatitidis, Blastomyces dermatitidis ER-3, Bordetella bronchiseptica (A0A0H3LIT0), Burkholderia cenocepacia (B4EE44), Burkholderia multivorans (B9BCZ1), Burkholderia multivorans CGD1 (B9BCZ1), Burkholderia sp. BT03, Butyrivibrio sp. MC2021, Calidithermus chliarophilus, Cellulophaga algicola DSM 14237, Chryseobacterium sp. UNC8MFCol, Desulfatibacillum aliphaticivorans, Drepanopeziza brunnea, Drepanopeziza brunnea MB_m1, Dyadobacter alkalitolerans, Flexithrix dorotheae, Fodinicurvata sediminis, Geodermatophilus obscurus (D2SGH7), Geodermatophilus obscurus ATCC 25078 (D2SGH7), Janthinobacterium sp. Marseille (A6T0X3), Maribacter antarcticus, Maricaulis maris, Maricaulis maris MCS10, Methanosarcina mazei (Q8PXI9), Methanosarcina mazei BAA-159 (Q8PXI9), Microscilla marina (A1ZD79), Microscilla marina ATCC 23134 (A1ZD79), Morganella morganii subsp. morganii, Morganella morganii subsp. morganii KT, Niabella soli, Niabella soli DSM 19437, Nocardiopsis dassonvillei ATCC 23218 (D7B8P3), Pantoea sp. AS-PWVM4, Parabacteroides gordonii, Pedobacter jeongneungensis, Pseudomonas entomophila (Q1I7X1), Pseudomonas entomophila L48 (Q1I7X1), Pseudomonas oleovorans, Pseudomonas oleovorans CECT:5344, Pseudomonas sp. GM41, Pseudonocardia spinosispora, Rhizobium leguminosarum bv. trifolii, Rhizobium leguminosarum bv. trifolii WSM1325, Rhodococcus aetherivorans, Rubellimicrobium mesophilum, Rubellimicrobium mesophilum DSM 19309, Runella slithyformis, Saccharomyces cerevisiae (B3LU11), Saccharomyces cerevisiae RM11-1a (B3LU11), Scheffersomyces stipitis (A3LXL4), Scheffersomyces stipitis ATCC 58785 (A3LXL4), Sediminispirochaeta bajacaliforniensis, Shewanella sediminis (A8FQL4), Shewanella sediminis HAW-EB3 (A8FQL4), Sphingobacterium thalpophilum, Stappia stellulata, Streptomyces albus (D6B7V7), Streptomyces albus J1074 (D6B7V7), Synechocystis sp. PCC 6803, Thalassiosira pseudonana (B8C1M9), Thalassospira lucentensis, Tomitella biformata
brenda
Lehmann, T.; Janowitz, T.; Sanchez-Parra, B.; Alonso, M.P.; Trompetter, I.; Piotrowski, M.; Pollmann, S.
Arabidopsis nitrilase 1 contributes to the regulation of root growth and development through modulation of auxin biosynthesis in seedlings
Front. Plant Sci.
8
36
2017
Arabidopsis thaliana (P32961), Arabidopsis thaliana
brenda