Information on EC 3.5.4.7 - ADP deaminase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.5.4.7
-
RECOMMENDED NAME
GeneOntology No.
ADP deaminase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ADP + H2O = IDP + NH3
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amidine hydrolysis
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ADP aminohydrolase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9027-79-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
no activity in Mucor javanicus
-
-
-
Manually annotated by BRENDA team
no activity in Mucor racemosus
-
-
-
Manually annotated by BRENDA team
no activity in Mucor rouxianus
-
-
-
Manually annotated by BRENDA team
no activity in Penicillium citrinum
-
-
-
Manually annotated by BRENDA team
no activity in Penicillium notatum
-
-
-
Manually annotated by BRENDA team
no activity in Rhizopus japonicus
-
-
-
Manually annotated by BRENDA team
no activity in Rhizopus nigricans
-
-
-
Manually annotated by BRENDA team
no activity in Rhizopus oryzae
-
-
-
Manually annotated by BRENDA team
no activity in Streptomyces aureofaciens
-
-
-
Manually annotated by BRENDA team
no activity in Streptomyces griseus
-
-
-
Manually annotated by BRENDA team
no activity in Streptomyces venezuelae
-
-
-
Manually annotated by BRENDA team
rabbit
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3',5'-adenosine monophosphate + H2O
3',5'-inosine monophosphate + NH3
show the reaction diagram
6-chloropurine riboside + H2O
inosine + Cl-
show the reaction diagram
6-chloropurine riboside monophosphate + H2O
inosine monophosphate + Cl-
show the reaction diagram
adenosine + H2O
inosine + NH3
show the reaction diagram
adenosine 3'-monophosphate + H2O
inosine 3'-monophosphate + NH3
show the reaction diagram
adenosine 5'-diphosphate + H2O
inosine 5'-diphosphate + NH3
show the reaction diagram
adenosine 5'-monophosphate + H2O
inosine 5'-phosphate + NH3
show the reaction diagram
adenosine 5'-monosulfate + H2O
inosine 5'-monosulfate + NH3
show the reaction diagram
adenosine 5'-tetraphosphate + H2O
inosine 5'-monophosphate + NH3
show the reaction diagram
adenosine 5'-triphosphate + H2O
inosine 5'-triphosphate + NH3
show the reaction diagram
adenosine diphosphate + H2O
inosine diphosphate + NH3
show the reaction diagram
adenosine sulfate + H2O
inosine sulfate + NH3
show the reaction diagram
adenosine tetraphosphate + H2O
inosine 5'-tetraphosphate + NH3
show the reaction diagram
adenosine triphosphate + H2O
inosine triphosphate + NH3
show the reaction diagram
deoxyadenosine monophosphate + H2O
deoxyinosine monophosphate + NH3
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
adenosine diphosphate + H2O
inosine diphosphate + NH3
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6-Chloropurine ribotide
-
competitive inhibition
Ag+
-
1 mM, inhibition 55%
Ca2+
-
20 mM, inhibition 31%
diphosphate
-
-
Fe3+
-
0.05 mM, inhibition 44%
Hg2+
-
10 mM, inhibition 39%
Mg2+
-
10 mM, inhibition 34%
PCMB
-
0.1 mM, inhibition 49%
Zn2+
-
20 mM, inhibition 36%
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.48 - 1.1
6-Chloropurine riboside
0.125 - 0.13
adenosine
0.066
adenosine 5'-diphosphate
-
-
0.072
adenosine 5'-monophosphate
-
-
0.032
Adenosine 5'-triphosphate
-
-
0.04 - 0.066
Adenosine diphosphate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 7
-
stable in this range, unstable at its optimum pH
209715
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE