Reference on EC 3.5.4.5 - cytidine deaminase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ipata, P.L.; Cercignani, G.
Cytosine and cytidine deaminase from yeast
Methods Enzymol.
51
394-401
1978
Saccharomyces cerevisiae, Escherichia coli, Mus musculus, Mus musculus BALB/c
Le Floc`h, F.; Guillot, A.
La desoxycytidine aminohydrolase des feuilles de Zea mays
Phytochemistry
13
2503-2509
1974
Zea mays
-
Cullen, B.R.; Bick, M.D.
Bromodeoxyuridine induction of deoxycytidine deaminase activity in a hamster cell line
Biochim. Biophys. Acta
517
158-168
1978
Cricetinae, Mus musculus
Chan, T.S.; Lakhchaura, B.D.; Hsu, T.F.
Differences in deoxycytidine metabolism in mouse and rat
Biochem. J.
210
367-371
1983
Mus musculus
Kang, M.S.; Rhee, J.G.; Cho, J.M.
Metabolism of pyrimidine deoxyribonucleotides and heat-resistivity of CdR-aminohydrolase in the mouse small intestine
Korean J. Zool.
17
107-116
1974
Mus musculus
-
Taketo, A.; Kuno, S.
Internal localization of nucleoside-catabolic enzymes in Escherichia coli
J. Biochem.
72
1557-1563
1972
Escherichia coli
Jahns-Streubel, G.; Unterhalt, M.; Schleyer, E.; Reuter, C.; Wrmann, B.; Buchner, T.; Hiddemann, W.
Correlation of deoxycytidine deaminase, thymidine kinase and polymerase alpha activity and deoxycytidine deaminase gene expression in vivo with clinical response to TAD-9+GM-CSF induction therapy in acute myeloid leukemia
Haematol. Blood Transfus.
38
252-259
1997
Homo sapiens
-
Mancini, W.R.
The role of deoxycytidine-metabolizing enzymes in the cytotoxicity induced by 3'-amino-2',3'-dideoxycytidine and cytosine arabinoside
Cancer Chemother. Pharmacol.
30
139-144
1992
Homo sapiens
Ruiz van Haperen, V.W.T.; Veerman, G.; Braakhuis, B.J.M.; Vermorken, J.B.; Boven, E.; Leyva, A.; Peters, G.J.
Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts
Eur. J. Cancer
29A
2132-2137
1993
Homo sapiens
Kroep, J.R.; van Moorsel, C.J.A.; Veerman, G.; Voorn, D.A.; Schultz, R.M.; Worzalla, J.F.; Tanzer, L.R.; Merriman, R.L.; Pinedo, H.M.; Peters, G.J.
Role of deoxycytidine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytidine deaminase (dCDA) in the antitumour activity of gemcitabine (dFdC)
Adv. Exp. Med. Biol.
431
657-660
1998
Homo sapiens
Wang, T.P.; Sable, H.Z.; Lampen, J.O.
Enzymatic deamination of cytosine nucleosides
J. Biol. Chem.
184
17-28
1950
Bos taurus, Saccharomyces cerevisiae, Oryctolagus cuniculus, Escherichia coli, Mus musculus, Escherichia coli 15 (ATCC 9723), Mus musculus BALB/c
Cohen, R.M.; Wolfenden, R.
Cytidine deaminase from Escherichia coli. Purification, properties and inhibition by the potential transition state analog 3,4,5,6-tetrahydrouridine
J. Biol. Chem.
246
7561-7565
1971
Saccharomyces cerevisiae, Escherichia coli, Ovis aries, Homo sapiens, Mus musculus, Escherichia coli B / ATCC 11303, Mus musculus BALB/c
Betts, L.; Xiang, S.; Short, S.A.; Wolfenden, R.; Carter, C.W.jr.
Cytidine deaminase.The 2.3 A crystal structure of an enzyme: Transition-state analog complex
J. Mol. Biol.
235
635-656
1994
Escherichia coli
Abell, C.W.; Marchand, N.W.
Cytidine deaminase in human lymphocytes
Nature New Biol.
244
217-219
1973
Homo sapiens
Hosono, H.; Kuno, S.
The purification and properties of cytidine deaminase from Escherichia coli
J. Biochem.
74
797-803
1973
Bacillus cereus, Saccharomyces cerevisiae, Escherichia coli, Ovis aries, Mus musculus, Mus musculus BALB/c, Escherichia coli Y-70-272
Wentworth, D.F.; Wolfenden, R.
On the interaction of 3,4,5,6-tetrahydrouridine with human liver cytidine deaminase
Biochemistry
14
5099-5105
1975
Escherichia coli, Homo sapiens
Evans, B.E.; Mitchell, G.N.; Wolfenden, R.
The action of bacterial cytidine deaminase on 5,6-dihydrocytidine
Biochemistry
14
621-624
1975
Escherichia coli
Wentworth, D.F.; Wolfenden, R.
Cytidine deaminases (from Escherichia coli and human liver)
Methods Enzymol.
51
401-407
1978
Canis lupus familiaris, Cavia porcellus, Columba sp., Oryctolagus cuniculus, Escherichia coli, Felis catus domesticus, Homo sapiens, Macaca mulatta, Mus musculus, Rana sp., Rattus norvegicus, Sus scrofa, Escherichia coli B / ATCC 11303, Mus musculus BALB/c
Rothman, I.K.; Malathi, V.G.; Silber, R.
Cytidine deaminase from leukemic mouse spleen
Methods Enzymol.
51
408-412
1978
Homo sapiens, Mus musculus, Mus musculus BALB/c
Ashley, G.W.; Bartlett, P.A.
A phosphorus-containing pyrimidine analog as a potent inhibitor of cytidine deaminase
Biochem. Biophys. Res. Commun.
108
1467-1474
1982
Escherichia coli, Escherichia coli B / ATCC 11303
Kara, J.; Bartova, M.; Ryba, M.; Hrebabecky, H.; Brokes, J.; Novotny, L.; Baranek, J.
Sensitivity of some arabinosylcytosine derivatives to enzymatic deamination by cytidine deaminase from mouse kidney
Collect. Czech. Chem. Commun.
47
2824-2830
1982
Mus musculus, Mus musculus BALB/c
-
Kidder, G.W.
Characteristics of cytidine aminohydrolase activity in Trypanosoma cruzi and Crithidia fasciculata
J. Protozool.
31
298-300
1984
Crithidia fasciculata, Trypanosoma cruzi
Ashley, G.W.; Bartlett, P.A.
Purification and properties of cytidine deaminase from escherichia coli
J. Biol. Chem.
259
13615-13620
1984
Saccharomyces cerevisiae, Escherichia coli, Ovis aries, Homo sapiens, Mus musculus, Zea mays, Escherichia coli B / ATCC 11303, Mus musculus BALB/c
Ashley, G.W.; Bartlett, P.A.
Inhibition of Escherichia coli cytidine deaminase by a phosphopyrimidine nucleoside
J. Biol. Chem.
259
13621-13627
1984
Escherichia coli, Homo sapiens
Vita, A.; Amici, A.; Cacciamani, T.; Lanciotti, M.; Magni, G.
Cytidine deaminase from Escherichia coli B. Purification and enzymatic and molecular properties
Biochemistry
24
6020-6024
1985
Escherichia coli, Escherichia coli B / ATCC 11303
Holy, A.; Ludzisa, A.; Votruba, I.; Sediva, K.
Preparation of analogues of cytosine and 2-pyrimidinone nucleosides and their effect on bacterial (Escherichia coli A19) cytidine aminohydrolase
Collect. Czech. Chem. Commun.
50
393-417
1985
Saccharomyces cerevisiae, Escherichia coli, Macaca mulatta, Mus musculus, Mus musculus BALB/c, Escherichia coli A19
-
Fanucchi, M.P.; Watanabe, K.A.; Fox, J.J.; Chou, T.
Kinetics and substrate specificity of human and canine cytidine deaminase
Biochem. Pharmacol.
35
1199-1201
1986
Canis lupus familiaris, Homo sapiens
Vita, A.; Amici, A.; Lanciotti, M.; Cacciamani, T.; Magni, G.
Further properties of cytidine deaminase and uridine phosphorylase from E. coli B
Ital. J. Biochem.
35
145A-147A
1986
Escherichia coli, Escherichia coli B / ATCC 11303
-
Nygaard, P.
On the role of cytidine deaminase in cellular metabolism
Adv. Exp. Med. Biol.
195B
415-420
1986
Saccharomyces cerevisiae, Escherichia coli, Ovis aries, Homo sapiens, Mus musculus, no activity in Lactobacillus sp., no activity in Moraxella sp., no activity in Pseudomonas sp., Salmonella enterica subsp. enterica serovar Typhimurium, Zea mays, Mus musculus BALB/c
Kwon, T.K.; Lee, S.Y.; Kim, J.G.; Song, B.H.; Hong, S.D.
Purification and properties of Escherichia coli cytidine deaminase by amplification of the cdd gene
Mol. Cells
1
281-286
1991
Geobacillus stearothermophilus, Bacillus subtilis, Saccharomyces cerevisiae, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli JF611
-
Cacciamani, T.; Vita, A.; Cristalli, G.; Vincenzetti, S.; Natalini, P.; Ruggieri, S.; Amici, A.; Magni, G.
Purification of human cytidine deaminase: Molecular and enzymatic characterization and inhibition by synthetic pyrimidine analogs
Arch. Biochem. Biophys.
290
285-292
1991
Canis lupus familiaris, Gallus gallus, Escherichia coli, Homo sapiens, Mus musculus, no activity in Lactobacillus sp., no activity in Moraxella sp., no activity in Pseudomonas sp., Mus musculus BALB/c
Barchi, J.J.; Haces, A.; Marquez, V.E.; McCormack, J.J.
Inhibition of cytidine deaminase by derivatives of 1-(beta-D-ribofuranosyl)-dihydropyrimidin-2-one(zebularine)
Nucleosides Nucleotides
11
1781-1793
1992
Homo sapiens, Mus musculus, Mus musculus BALB/c
-
Bouffard, D.Y.; Laliberte, J.; Momparler, R.L.
Kinetic studies on 2',2'-difluorodeoxycytidine (gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase
Biochem. Pharmacol.
45
1857-1861
1993
Homo sapiens
Smith, A.A.; Carlow, D.C.; Wolfenden, R.; Short, S.A.
Mutations affecting transition-state stabilization by residues coordinating zinc at the active site of cytidine deaminase
Biochemistry
33
6468-6474
1994
Escherichia coli
Vincenzetti, S.; Cambi, A.; Neuhard, J.; Garattini, E.; Vita, A.
Recombinant human cytidine deaminase: Expression, purification, and characterization
Protein Expr. Purif.
8
247-253
1996
Bacillus subtilis, Escherichia coli, Homo sapiens, Escherichia coli DH5-alpha
Vincenzetti, S.; Cambi, A.; Balducci, E.; Natalini, P.; Volpini, R.; Vita, A.
Human placenta cytidine deaminase: A zinc metalloprotein
Biochemistry
42
469-476
1997
Bacillus subtilis, Homo sapiens
Carlow, D.C.; Carter, C.W.; Mejlhede, N.; Neuhard, J.; Wolfenden, R.
Cytidine deaminases from B. subtilis and E. coli: Compensating effects of changing zinc coordination and quaternary structure
Biochemistry
38
12258-12265
1999
Bacillus subtilis, Escherichia coli, Homo sapiens, Escherichia coli SO268
Vincenzetti, S.; Cambi, A.; Neuhard, J.; Schnorr, K.; Grelloni, M.; Vita, A.
Cloning, expression, and purification of cytidine deaminase from Arabidopsis thaliana
Protein Expr. Purif.
15
8-15
1999
Arabidopsis thaliana, Bacillus subtilis, Gallus gallus, Escherichia coli, Haemophilus influenzae, Ovis aries, Mus musculus, Escherichia coli SO5201, Mus musculus BALB/c
Faivre-Nitschke, E.; Grienenberger, J.M.; Gualberto, J.M.
A prokaryotic-type cytidine deaminase from Arabidopsis thaliana gene expression and functional characterization
Eur. J. Biochem.
263
896-903
1999
Arabidopsis thaliana, Bacillus subtilis, Saccharomyces cerevisiae, Brugia pahangi, Caenorhabditis elegans, Escherichia coli, Haemophilus influenzae, Homo sapiens, Mycoplasma pneumoniae, Escherichia coli BL21(D3)
Sakai, T.; Daikai, T.; Monma, H.; Maeda, H.
Isolation from Nocardioides sp. strain CT16, purification, and characterization of a deoxycytidine deaminase extremely thermostable in the presence of DL-dithiothreitol
Biosci. Biotechnol. Biochem.
66
1646-1651
2002
Nocardioides sp., Nocardioides sp. CT16
Johansson, E.; Mejlhede, N.; Neuhard, J.; Larsen, S.
Crystal structure of the tetrameric cytidine deaminase from Bacillus subtilis at 2.0 A resolution
Biochemistry
41
2563-2570
2002
Bacillus subtilis (P19079), Bacillus subtilis
Johansson, E.; Neuhard, J.; Willemoes, M.; Larsen, S.
Structural, kinetic, and mutational studies of the zinc ion environment in tetrameric cytidine deaminase
Biochemistry
43
6020-6029
2004
Bacillus subtilis (P19079)
Cambi, A.; Vincenzetti, S.; De Sanctis, G.; Neuhard, J.; Natalini, P.; Vita, A.
Cytidine deaminase from two extremophilic bacteria: cloning, expression and comparison of their structural stability
Protein Eng.
14
807-813
2001
Bacillus subtilis, [Bacillus] caldolyticus (Q9R2S1), [Bacillus] caldolyticus, Sporosarcina psychrophila (Q9S3M0), Sporosarcina psychrophila
Vincenzetti, S.; de Sanctis, G.; Costanzi, S.; Cristalli, G.; Mariani, P.; Mei, G.; Neuhard, J.; Natalini, P.; Polzonetti, V.; Vita, A.
Functional properties of subunit interactions in human cytidine deaminase
Protein Eng.
16
1055-1061
2003
Homo sapiens
Teh, A.H.; Kimura, M.; Yamamoto, M.; Tanaka, N.; Yamaguchi, I.; Kumasaka, T.
The 1.48 A resolution crystal structure of the homotetrameric cytidine deaminase from mouse
Biochemistry
45
7825-7833
2006
Mus musculus (P56389), Mus musculus
Elshafei, A.M.; Ali, N.H.; Mohamed, L.A.
Cytidine deaminase activity in Penicillium politans NRC-510
J. Basic Microbiol.
45
335-343
2005
Penicillium palitans, Penicillium palitans NRC 510
Matsubara, T.; Ishikura, M.; Aida, M.
A quantum chemical study of the catalysis for cytidine deaminase: contribution of the extra water molecule
J. Chem. Inf. Model.
46
1276-1285
2006
Escherichia coli (P0ABF6)
Chung, S.J.; Fromme, J.C.; Verdine, G.L.
Structure of human cytidine deaminase bound to a potent inhibitor
J. Med. Chem.
48
658-660
2005
Homo sapiens
Costanzi, S.; Vincenzetti, S.; Cristalli, G.; Vita, A.
Human cytidine deaminase: A three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologue
J. Mol. Graph. Model.
25
10-16
2006
Homo sapiens
Vincenzetti, S.; Mariani, P.L.; Cammertoni, N.; Polzonetti, V.; Natalini, P.; Quadrini, B.; Volpini, R.; Vita, A.
Isoenzymatic forms of human cytidine deaminase
Protein Eng. Des. Sel.
17
871-877
2004
Homo sapiens
Lemaire, M.; Momparler, L.F.; Raynal, N.J.; Bernstein, M.L.; Momparler, R.L.
Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2-deoxycytidine
Cancer Chemother. Pharmacol.
63
411-416
2009
Homo sapiens
Matsubara, T.; Dupuis, M.; Aida, M.
The ONIOM molecular dynamics method for biochemical applications: cytidine deaminase
Chem. Phys. Lett.
437
138-142
2007
Homo sapiens
-
Vincenzetti, S.; Quadrini, B.; Mariani, P.; De Sanctis, G.; Cammertoni, N.; Polzonetti, V.; Pucciarelli, S.; Natalini, P.; Vita, A.
Modulation of human cytidine deaminase by specific amino acids involved in the intersubunit interactions
Proteins
70
144-156
2007
Homo sapiens
Parise, R.A.; Egorin, M.J.; Eiseman, J.L.; Joseph, E.; Covey, J.M.; Beumer, J.H.
Quantitative determination of the cytidine deaminase inhibitor tetrahydrouridine (THU) in mouse plasma by liquid chromatography/electrospray ionization tandem mass spectrometry
Rapid Commun. Mass Spectrom.
21
1991-1997
2007
Mus musculus
Sigmond, J.; Honeywell, R.J.; Postma, T.J.; Dirven, C.M.; de Lange, S.M.; van der Born, K.; Laan, A.C.; Baayen, J.C.; Van Groeningen, C.J.; Bergman, A.M.; Giaccone, G.; Peters, G.J.
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer
Ann. Oncol.
20
182-187
2009
Homo sapiens
Besnard, T.; Renee, N.; Etienne-Grimaldi, M.; Francois, E.; Milano, G.
Optimized blood sampling with cytidine deaminase inhibitor for improved analysis of capecitabine metabolites
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
870
117-120
2008
Homo sapiens
Giovannetti, E.; Laan, A.C.; Vasile, E.; Tibaldi, C.; Nannizzi, S.; Ricciardi, S.; Falcone, A.; Danesi, R.; Peters, G.J.
Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples
Nucleosides Nucleotides Nucleic Acids
27
720-725
2008
Homo sapiens
Wu, L.; Wu, X.; Zhu, B.; Cao, X.
Identification and functional characterization of a novel cytidine deaminase in a gastropod abalone, Haliotis diversicolor supertexta
Dev. Comp. Immunol.
33
709-717
2009
Haliotis diversicolor supertexta (C0IL37), Haliotis diversicolor supertexta
Park, Y.M.; Phi, Q.T.; Song, B.H.; Ghim, S.Y.
Thermostability of chimeric cytidine deaminase variants produced by DNA shuffling
J. Microbiol. Biotechnol.
19
1536-1541
2009
Geobacillus stearothermophilus, [Bacillus] caldolyticus, Geobacillus stearothermophilus IFO12550 (T101), [Bacillus] caldolyticus DSM 405 (T53)
Sanchez-Quitian, Z.A.; Schneider, C.Z.; Ducati, R.G.; de Azevedo, W.F.; Bloch, C.; Basso, L.A.; Santos, D.S.
Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase
J. Struct. Biol.
169
413-423
2010
Mycobacterium tuberculosis (P9WPH3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPH3)
Sanchez-Quitian, Z.A.; Timmers, L.F.; Caceres, R.A.; Rehm, J.G.; Thompson, C.E.; Basso, L.A.; de Azevedo, W.F.; Santos, D.S.
Crystal structure determination and dynamic studies of Mycobacterium tuberculosis cytidine deaminase in complex with products
Arch. Biochem. Biophys.
509
108-115
2011
Mycobacterium tuberculosis (P9WPH3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPH3)
Shibu, M.A.; Yang, H.H.; Lo, C.T.; Lin, H.S.; Liu, S.Y.; Peng, K.C.
Characterization of a novel resistance-related deoxycytidine deaminase from Brassica oleracea var. capitata
J. Agric. Food Chem.
62
1796-1801
2014
Brassica oleracea
Liu, W.; Shang, F.; Chen, Y.; Lan, J.; Wang, L.; Chen, J.; Gao, P.; Ha, N.C.; Quan, C.; Nam, K.H.; Xu, Y.
Biochemical and structural analysis of the Klebsiella pneumoniae cytidine deaminase CDA
Biochem. Biophys. Res. Commun.
519
280-286
2019
Klebsiella pneumoniae subsp. pneumoniae (A6TBN1), Klebsiella pneumoniae subsp. pneumoniae ATCC 700721 (A6TBN1)
Tibaldi, C.; Camerini, A.; Tiseo, M.; Mazzoni, F.; Barbieri, F.; Vittimberga, I.; Brighenti, M.; Boni, L.; Baldini, E.; Gilli, A.; Honeywell, R.; Chartoire, M.; Peters, G.J.; Giovannetti, E.; Giovannetti, E.
Cytidine deaminase enzymatic activity is a prognostic biomarker in gemcitabine/platinum-treated advanced non-small-cell lung cancer a prospective validation study
Br. J. Cancer
119
1326-1331
2018
Homo sapiens (P32320), Homo sapiens
Furusho, K.; Shibata, T.; Sato, R.; Fukui, R.; Motoi, Y.; Zhang, Y.; Saitoh, S.I.; Ichinohe, T.; Moriyama, M.; Nakamura, S.; Miyake, K.
Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs
Int. Immunol.
31
167-173
2019
Homo sapiens (P32320)
Sanchez-Quitian, Z.; Rodrigues-Junior, V.; Rehm, J.; Eichler, P.; Barbosa Trivella, D.; Bizarro, C.; Basso, L.; Santos, D.
Functional and structural evidence for the catalytic role played by glutamate-47 residue in the mode of action of Mycobacterium tuberculosis cytidine deaminase
RSC Adv.
5
830-840
2015
Mycobacterium tuberculosis (P9WPH3), Mycobacterium tuberculosis H37Rv (P9WPH3)
-
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