Information on EC 3.5.4.46 - cAMP deaminase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.5.4.46
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RECOMMENDED NAME
GeneOntology No.
cAMP deaminase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3',5'-cyclic AMP + H2O = 3',5'-cyclic IMP + NH3
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
3',5'-cyclic AMP aminohydrolase
Requires Zn2+. The enzyme, isolated from the bacterium Leptospira interrogans, is specific for cAMP.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
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UniProt
Manually annotated by BRENDA team
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni Fiocruz L1-130
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3',5'-cyclic AMP + H2O
3',5'-cyclic IMP + NH3
show the reaction diagram
additional information
?
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.17
3',5'-cyclic AMP
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
pH 7.5, 30°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
46
3',5'-cyclic AMP
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
pH 7.5, 30°C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
270
3',5'-cyclic AMP
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
pH 7.5, 30°C
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni