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Disease on EC 3.5.4.38 - single-stranded DNA cytosine deaminase

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DISEASE
TITLE OF PUBLICATION
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Acquired Immunodeficiency Syndrome
APOBEC3B deletion and risk of HIV-1 acquisition.
APOBEC3H polymorphisms associated with the susceptibility to HIV-1 infection and AIDS progression in Japanese.
No evidence of an association between the APOBEC3B deletion polymorphism and susceptibility to HIV infection and AIDS in Japanese and Indian populations.
Adenocarcinoma
Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.
Adenocarcinoma of Lung
APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors.
Adrenocortical Carcinoma
GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3.
Asthma
Familial Success in Allergen Desensitization.
Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.
Breast Neoplasms
Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population.
APOBEC3 cytidine deaminases in double-strand DNA break repair and cancer promotion.
APOBEC3 deletion polymorphism is associated with breast cancer risk among women of European ancestry.
APOBEC3A is a prominent cytidine deaminase in breast cancer.
APOBEC3B expression and its prognostic potential in breast cancer.
APOBEC3B expression in breast cancer cell lines and tumors depends on the estrogen receptor status.
APOBEC3B expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation.
APOBEC3B expression in drug resistant MCF-7 breast cancer cell lines.
APOBEC3B gene expression as a novel predictive factor for pathological complete response to neoadjuvant chemotherapy in breast cancer.
APOBEC3B Gene Expression in Ductal Carcinoma In Situ and Synchronous Invasive Breast Cancer.
APOBEC3B high expression status is associated with aggressive phenotype in Japanese breast cancers.
APOBEC3B is an enzymatic source of mutation in breast cancer.
APOBEC3B is expressed in human glioma, and influences cell proliferation and temozolomide resistance.
Assessment of an APOBEC3B truncating mutation, c.783delG, in patients with breast cancer.
Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer.
Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors.
Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B.
Clinical implications of APOBEC3A and 3B expression in patients with breast cancer.
DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.
DNA replication stress: a source of APOBEC3B expression in breast cancer.
Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers.
Evidence for APOBEC3B mutagenesis in multiple human cancers.
Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women.
Expression of DNA cytosine deaminase APOBEC3 proteins, a potential source for producing mutations, in gastric, colorectal and prostate cancers.
Germline APOBEC3B deletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype, PIK3CA mutations, and immune activation.
Germline APOBEC3B deletion influences clinicopathological parameters in luminal-A breast cancer: evidences from a southern Brazilian cohort.
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.
Identifying germline APOBEC3B deletion and immune phenotype in Korean patients with operable breast cancer.
Immune gene expression profiling reveals heterogeneity in luminal breast tumors.
Impact of functional germline variants and a deletion polymorphism in APOBEC3A and APOBEC3B on breast cancer risk and survival in a Swedish study population.
Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer.
PrimPol prevents APOBEC/AID family mediated DNA mutagenesis.
Progressive APOBEC3B mRNA expression in distant breast cancer metastases.
The 29.5 kb APOBEC3B Deletion Polymorphism Is Not Associated with Clinical Outcome of Breast Cancer.
The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.
Carcinogenesis
APOBEC3A catalyzes mutation and drives carcinogenesis in vivo.
APOBEC3B Gene Expression in Ductal Carcinoma In Situ and Synchronous Invasive Breast Cancer.
APOBEC3B is an enzymatic source of molecular alterations in esophageal squamous cell carcinoma.
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like family genes activation and regulation during tumorigenesis.
Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.
Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses.
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.
In vivo and in vitro studies suggest a possible involvement of HPV infection in the early stage of breast carcinogenesis via APOBEC3B induction.
Phosphorylation Directly Regulates the Intrinsic DNA Cytidine Deaminase Activity of Activation-induced Deaminase and APOBEC3G Protein.
Progesterone inhibits activation-induced deaminase by binding to the promoter.
Single-Molecule Force Spectroscopy Studies of APOBEC3A-Single-Stranded DNA Complexes.
Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination.
The emerging role of estrogen in B cell malignancies.
The rabbit as an orthologous small animal model for APOBEC3A oncogenesis.
Carcinoma
APOBEC3A Expression in Penile Squamous Cell Carcinoma.
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism.
APOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 Expression.
APOBEC3B is an enzymatic source of molecular alterations in esophageal squamous cell carcinoma.
APOBEC3B protein expression and mRNA analyses in patients with high-grade serous ovarian carcinoma.
APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.
Evidence for APOBEC3B mRNA and protein expression in oral squamous cell carcinomas.
High APOBEC3B expression is a predictor of recurrence in patients with low-risk clear cell renal cell carcinoma.
Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study.
Involvement of APOBEC3B in mutation induction by irradiation.
Prognostic Impact of APOBEC3B Expression in Metastatic Urothelial Carcinoma and Its Association with Tumor-Infiltrating Cytotoxic T Cells.
Carcinoma, Ductal
APOBEC3B Gene Expression in Ductal Carcinoma In Situ and Synchronous Invasive Breast Cancer.
Carcinoma, Hepatocellular
APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells.
APOBEC3B interaction with PRC2 modulates microenvironment to promote HCC progression.
APOBEC3B: A Potential Factor Suppressing Growth of Human Hepatocellular Carcinoma Cells.
Association of Hepatitis B Virus Covalently Closed Circular DNA and Human APOBEC3B in Hepatitis B Virus-Related Hepatocellular Carcinoma.
Associations between the single nucleotide polymorphisms of APOBEC3A, APOBEC3B and APOBEC3H, and chronic hepatitis B progression and hepatocellular carcinoma in a Chinese population.
Bufalin inhibits cell proliferation and migration of hepatocellular carcinoma cells via APOBEC3F induced intestinal immune network for IgA production signaling pathway.
Evidence of associations of APOBEC3B gene deletion with susceptibility to persistent HBV infection and hepatocellular carcinoma.
HBx-elevated MSL2 Modulates HBV cccDNA through Inducing Degradation of APOBEC3B to Enhance Hepatocarcinogenesis.
Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H.
Long non-coding RNA HULC activates HBV by modulating HBx/STAT3/miR-539/APOBEC3B signaling in HBV-related hepatocellular carcinoma.
Overexpression of APOBEC3F in tumor tissues is potentially predictive for poor recurrence-free survival from HBV-related hepatocellular carcinoma.
Carcinoma, Intraductal, Noninfiltrating
APOBEC3B Gene Expression in Ductal Carcinoma In Situ and Synchronous Invasive Breast Cancer.
Carcinoma, Non-Small-Cell Lung
APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer.
Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study.
Carcinoma, Renal Cell
High APOBEC3B expression is a predictor of recurrence in patients with low-risk clear cell renal cell carcinoma.
Carcinoma, Squamous Cell
APOBEC3A Expression in Penile Squamous Cell Carcinoma.
Chondrosarcoma
The role of APOBEC3B in chondrosarcoma.
Coinfection
The APOBEC3B deletion polymorphism is associated with prevalence of hepatitis B virus, hepatitis C virus, Torque Teno virus, and Toxoplasma gondii co-infection among HIV-infected individuals.
Communicable Diseases
The APOBEC3B deletion polymorphism is associated with prevalence of hepatitis B virus, hepatitis C virus, Torque Teno virus, and Toxoplasma gondii co-infection among HIV-infected individuals.
Condylomata Acuminata
Heat-Induced Editing of HPV Genes to Clear Mucocutaneous Warts?
COVID-19
Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants.
Esophageal Squamous Cell Carcinoma
APOBEC3B is an enzymatic source of molecular alterations in esophageal squamous cell carcinoma.
Glioma
APOBEC3B is expressed in human glioma, and influences cell proliferation and temozolomide resistance.
Correlation Between APOBEC3B Expression and Clinical Characterization in Lower-Grade Gliomas.
Development of a prognostic model of glioma based on immune-related genes.
Head and Neck Neoplasms
Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers.
GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3.
Hepatitis B
APOBEC3DE Antagonizes Hepatitis B Virus Restriction Factors APOBEC3F and APOBEC3G.
Association of Hepatitis B Virus Covalently Closed Circular DNA and Human APOBEC3B in Hepatitis B Virus-Related Hepatocellular Carcinoma.
Cell-specific regulation of APOBEC3F by interferons.
Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses hepatitis B virus expression.
Different antiviral activities of natural APOBEC3C, APOBEC3G, and APOBEC3H variants against hepatitis B virus.
Effects of point mutations in the cytidine deaminase domains of APOBEC3B on replication and hypermutation of hepatitis B virus in vitro.
Hepatitis B virus DNA is subject to extensive editing by the human deaminase APOBEC3C.
Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H.
Interferon-? and Tumor Necrosis Factor-? Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.
Interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication.
The APOBEC3B deletion polymorphism is associated with prevalence of hepatitis B virus, hepatitis C virus, Torque Teno virus, and Toxoplasma gondii co-infection among HIV-infected individuals.
Virology. Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".
Hepatitis B, Chronic
Associations between the single nucleotide polymorphisms of APOBEC3A, APOBEC3B and APOBEC3H, and chronic hepatitis B progression and hepatocellular carcinoma in a Chinese population.
Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection.
Interferon-? and Tumor Necrosis Factor-? Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.
Polymorphic APOBEC3 modulates chronic hepatitis B in Moroccan population.
Hepatitis C
The APOBEC3B deletion polymorphism is associated with prevalence of hepatitis B virus, hepatitis C virus, Torque Teno virus, and Toxoplasma gondii co-infection among HIV-infected individuals.
Herpes Simplex
Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo.
Human Herpes Simplex Virus-1 depletes APOBEC3A from nuclei.
In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.
HIV Infections
APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.
APOBEC3B deletion impacts on susceptibility to acquire HIV-1 and its advancement among individuals in western India.
No evidence of an association between the APOBEC3B deletion polymorphism and susceptibility to HIV infection and AIDS in Japanese and Indian populations.
Stably expressed APOBEC3F has negligible antiviral activity.
Hypersensitivity
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
Hypertension
A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension microarray data.
Infections
A functional variant in UBE2L3 contributes to HBV infection and maintains cccDNA stability by inducing degradation of APOBEC3A protein.
A positively selected APOBEC3H haplotype is associated with natural resistance to HIV-1 infection.
Analysis of single-nucleotide polymorphisms in the APOBEC3H gene of domestic cats (Felis catus) and their association with the susceptibility to feline immunodeficiency virus and feline leukemia virus infections.
Antiretroelement activity of APOBEC3H was lost twice in recent human evolution.
APOBEC Enzymes as Targets for Virus and Cancer Therapy.
APOBEC proteins and intrinsic resistance to HIV-1 infection.
APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.
APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription.
APOBEC3B up-regulation independently predicts ovarian cancer prognosis: a cohort study.
APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo.
APOBEC3H haplotypes and HIV-1 pro-viral vif DNA sequence diversity in early untreated human immunodeficiency virus-1 infection.
APOBEC3H polymorphisms and susceptibility to HIV-1 infection in an Indian population.
APOBEC3H polymorphisms associated with the susceptibility to HIV-1 infection and AIDS progression in Japanese.
Biochemical differentiation of APOBEC3F and APOBEC3G proteins associated with HIV-1 life cycle.
Candida albicans Delays HIV-1 Replication in Macrophages.
Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus.
Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets.
Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection.
Evidence of associations of APOBEC3B gene deletion with susceptibility to persistent HBV infection and hepatocellular carcinoma.
Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses.
Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases.
HPV-16/18 E6-induced APOBEC3B expression associates with proliferation of cervical cancer cells and hypomethylation of Cyclin D1.
Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection.
Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif.
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.
Identification of APOBEC3B promoter elements responsible for activation by human papillomavirus type 16 E6.
Infection of Bronchial Epithelial Cells by the Human Adenoviruses A12, B3, and C2 Differently Regulates the Innate Antiviral Effector APOBEC3B.
Lack of Association between Intact/Deletion Polymorphisms of the APOBEC3B Gene and HIV-1 Risk.
Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3G.
Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity.
Relationship between human immunodeficiency type 1 infection and expression of human APOBEC3G and APOBEC3F.
The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells.
The Range of Human APOBEC3H Sensitivity to Lentiviral Vif Proteins.
The retroviral hypermutation specificity of APOBEC3F and APOBEC3G is governed by the C-terminal DNA cytosine deaminase domain.
The Role of Amino-Terminal Sequences in Cellular Localization and Antiviral Activity of APOBEC3B.
Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism.
Infectious Mononucleosis
Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity.
Influenza, Human
Relation of activation-induced deaminase (AID) expression with antibody response to A(H1N1)pdm09 vaccination in HIV-1 infected patients.
Leukemia
Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint.
Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.
Murine leukemia virus resists producer cell APOBEC3A by its Glycosylated Gag but not target cell APOBEC3A.
Leukemia, Feline
Analysis of single-nucleotide polymorphisms in the APOBEC3H gene of domestic cats (Felis catus) and their association with the susceptibility to feline immunodeficiency virus and feline leukemia virus infections.
Leukemia, Lymphocytic, Chronic, B-Cell
Activation-induced deaminase and its splice variants associate with trisomy 12 in chronic lymphocytic leukemia.
AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms.
IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.
Investigating epigenetic effects of activation-induced deaminase in chronic lymphocytic leukemia.
The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way.
Leukemia, Myeloid, Acute
Expression Profiles of DNA Methylation and Demethylation Machinery Components in Pediatric Myelodysplastic Syndrome: Clinical Implications.
Leukemia, T-Cell
Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases.
Liver Neoplasms
A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3'UTR enhances chromosomal DNA damage.
Hepatitis B: modern concepts in pathogenesis--APOBEC3 cytidine deaminases as effectors in innate immunity against the hepatitis B virus.
Lung Neoplasms
APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer.
APOBEC3B deletion polymorphism and lung cancer risk in the southern Chinese population.
APOBEC3B gene overexpression in non-small-cell lung cancer.
High CEP55 expression is associated with poor prognosis in non-small-cell lung cancer.
Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study.
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.
Single-nucleotide polymorphism of the DNA cytosine deaminase APOBEC3H haplotype I leads to enzyme destabilization and correlates with lung cancer.
The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.
The eQTL-missense polymorphisms of APOBEC3H are associated with lung cancer risk in a Han Chinese population.
Lupus Nephritis
Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritis.
The role of activation-induced deaminase in lupus nephritis.
Lymphatic Metastasis
APOBEC3B High Expression in Gastroenteropancreatic Neuroendocrine Neoplasms and Association With Lymph Metastasis.
HPV-16/18 E6-induced APOBEC3B expression associates with proliferation of cervical cancer cells and hypomethylation of Cyclin D1.
Progressive APOBEC3B mRNA expression in distant breast cancer metastases.
Lymphocytic Choriomeningitis
Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses.
Lymphoma
Altered Pattern of Immunoglobulin Hypermutation in Mice Deficient in Slip-GC Protein.
G-rich proto-oncogenes are targeted for genomic instability in B-cell lymphomas.
Identification of APOBEC3B as a potential target for the graft-versus-lymphoma effect by SEREX in a patient with mantle cell lymphoma.
Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.
Mechanisms of human lymphoid chromosomal translocations.
PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas.
Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells.
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells.
Speckled-like pattern in the germinal center (SLIP-GC): A nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells.
Lymphoma, B-Cell
Whole genome sequencing demonstrates substantial pathophysiological differences of MYC rearrangements in patients with plasma cell myeloma and B-cell lymphoma.
Lymphoma, Follicular
Intraclonal diversity in follicular lymphoma analyzed by quantitative ultradeep sequencing of noncoding regions.
Lymphoma, Mantle-Cell
Identification of APOBEC3B as a potential target for the graft-versus-lymphoma effect by SEREX in a patient with mantle cell lymphoma.
Malaria
Deletion of the APOBEC3B gene strongly impacts susceptibility to falciparum malaria.
Melanoma
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy.
Expression of AID in malignant melanoma with BRAF(V) (600E) mutation.
Meningioma
APOBEC3B expression in human leptomeninges and meningiomas.
Mouth Neoplasms
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism.
Multiple Myeloma
Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells.
Nasopharyngeal Carcinoma
The Prognostic Significance of APOBEC3B and PD-L1/PD-1 in Nasopharyngeal Carcinoma.
Neoplasm Metastasis
APOBEC Enzymes as Targets for Virus and Cancer Therapy.
APOBEC3B High Expression in Gastroenteropancreatic Neuroendocrine Neoplasms and Association With Lymph Metastasis.
APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase-independent activity.
HPV-16/18 E6-induced APOBEC3B expression associates with proliferation of cervical cancer cells and hypomethylation of Cyclin D1.
Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer.
Progressive APOBEC3B mRNA expression in distant breast cancer metastases.
The PKC/NF-?B signaling pathway induces APOBEC3B expression in multiple human cancers.
The Prognostic Significance of APOBEC3B and PD-L1/PD-1 in Nasopharyngeal Carcinoma.
Neoplasms
A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers.
A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3'UTR enhances chromosomal DNA damage.
A Rabbit Monoclonal Antibody against the Antiviral and Cancer Genomic DNA Mutating Enzyme APOBEC3B.
A Tumor-Promoting Phorbol Ester Causes a Large Increase in APOBEC3A Expression and a Moderate Increase in APOBEC3B Expression in a Normal Human Keratinocyte Cell Line without Increasing Genomic Uracils.
Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer.
Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B.
AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms.
An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.
An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
An extended APOBEC3A mutation signature in cancer.
Analysis of APOBEC3A/3B germline deletion polymorphism in breast, cervical and oral cancers from South India and its impact on miRNA regulation.
APOBEC Enzymes as Targets for Virus and Cancer Therapy.
APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity.
APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors.
APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication.
APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development.
APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition.
APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication.
APOBEC3A catalyzes mutation and drives carcinogenesis in vivo.
APOBEC3A Expression in Penile Squamous Cell Carcinoma.
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism.
APOBEC3B expression and its prognostic potential in breast cancer.
APOBEC3B expression in breast cancer cell lines and tumors depends on the estrogen receptor status.
APOBEC3B expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation.
APOBEC3B expression in drug resistant MCF-7 breast cancer cell lines.
APOBEC3B gene expression as a novel predictive factor for pathological complete response to neoadjuvant chemotherapy in breast cancer.
APOBEC3B High Expression in Gastroenteropancreatic Neuroendocrine Neoplasms and Association With Lymph Metastasis.
APOBEC3B high expression status is associated with aggressive phenotype in Japanese breast cancers.
APOBEC3B interaction with PRC2 modulates microenvironment to promote HCC progression.
APOBEC3B is an enzymatic source of molecular alterations in esophageal squamous cell carcinoma.
APOBEC3B is an enzymatic source of mutation in breast cancer.
APOBEC3B is expressed in human glioma, and influences cell proliferation and temozolomide resistance.
APOBEC3B mutagenesis in cancer.
APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces.
APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase-independent activity.
APOBEC3B up-regulation independently predicts ovarian cancer prognosis: a cohort study.
APOBEC3B, a molecular driver of mutagenesis in human cancers.
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy.
APOBEC3B: A Potential Factor Suppressing Growth of Human Hepatocellular Carcinoma Cells.
APOBEC3B: Pathological Consequences of an Innate Immune DNA Mutator.
APOBEC3G expression correlates with T cell infiltration and improved clinical outcomes in high-grade serous ovarian carcinoma.
APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction.
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like family genes activation and regulation during tumorigenesis.
Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma.
Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma.
B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers.
Biologically Aggressive Phenotype and Anti-cancer Immunity Counterbalance in Breast Cancer with High Mutation Rate.
Bufalin inhibits cell proliferation and migration of hepatocellular carcinoma cells via APOBEC3F induced intestinal immune network for IgA production signaling pathway.
Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B.
Classical NF-?B pathway is responsible for APOBEC3B expression in cancer cells.
Clinical implications of APOBEC3A and 3B expression in patients with breast cancer.
Comprehensive Mapping of Key Regulatory Networks that Drive Oncogene Expression.
Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.
Correlation Between APOBEC3B Expression and Clinical Characterization in Lower-Grade Gliomas.
Correlation of gene expression and associated mutation profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with chemosensitivity of cancer cell lines to drug treatment.
Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain.
Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-Dependent Manner.
Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint.
Degradation of the cancer genomic DNA deaminase APOBEC3B by SIV Vif.
Determinants of Oligonucleotide Selectivity of APOBEC3B.
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.
Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers.
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers.
Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B.
Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates.
Evidence for APOBEC3B mRNA and protein expression in oral squamous cell carcinomas.
Evidence for APOBEC3B mutagenesis in multiple human cancers.
Expression of AID in malignant melanoma with BRAF(V) (600E) mutation.
Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women.
Expression of DNA cytosine deaminase APOBEC3 proteins, a potential source for producing mutations, in gastric, colorectal and prostate cancers.
FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis.
Frame-shifted APOBEC3A encodes two alternative proapoptotic proteins that target the mitochondrial network.
GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3.
Genomic Instability Signature of Palindromic Non-Coding Somatic Mutations in Bladder Cancer.
Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways.
Germline APOBEC3B deletion influences clinicopathological parameters in luminal-A breast cancer: evidences from a southern Brazilian cohort.
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.
High APOBEC3B expression is a predictor of recurrence in patients with low-risk clear cell renal cell carcinoma.
Human APOBEC3A Isoforms Translocate to the Nucleus and Induce DNA Double Strand Breaks Leading to Cell Stress and Death.
Human APOBEC3B interacts with the heterogenous nuclear ribonucleoprotein A3 in cancer cells.
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.
Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B.
Identification of APOBEC3B promoter elements responsible for activation by human papillomavirus type 16 E6.
Identifying germline APOBEC3B deletion and immune phenotype in Korean patients with operable breast cancer.
Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way.
Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study.
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.
Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK-directed activation of NF-?B.
Induction of APOBEC3C Facilitates the Genotoxic Stress-Mediated Cytotoxicity of Artesunate.
Infection of Bronchial Epithelial Cells by the Human Adenoviruses A12, B3, and C2 Differently Regulates the Innate Antiviral Effector APOBEC3B.
Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution.
Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer types.
Integrative genomic analysis reveals functional diversification of APOBEC gene family in breast cancer.
Involvement of APOBEC3B in mutation induction by irradiation.
Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells.
LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype.
Mechanisms of base substitution mutagenesis in cancer genomes.
Mechanisms shaping the mutational landscape of the FRA3B/FHIT-deficient cancer genome.
Mechanistic basis for chromosomal translocations at the E2A gene and its broader relevance to human B cell malignancies.
Molecular basis of the attenuated phenotype of human APOBEC3B DNA mutator enzyme.
Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer.
Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA.
Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B.
Nucleotide Weight Matrices Reveal Ubiquitous Mutational Footprints of AID/APOBEC Deaminases in Human Cancer Genomes.
Observation by Real-Time NMR and Interpretation of Length- and Location-Dependent Deamination Activity of APOBEC3B.
Onset of deaminase APOBEC3B induction in response to DNA double-strand breaks.
Overexpression of APOBEC3F in tumor tissues is potentially predictive for poor recurrence-free survival from HBV-related hepatocellular carcinoma.
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.
Pan-cancer transcriptomic analysis dissects immune and proliferative functions of APOBEC3 cytidine deaminases.
Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features.
PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas.
Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism.
Progressive APOBEC3B mRNA expression in distant breast cancer metastases.
Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation.
Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots.
Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.
Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity.
RNA-Mediated Dimerization of the Human Deoxycytidine Deaminase APOBEC3H Influences Enzyme Activity and Interaction with Nucleic Acids.
Role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancer.
Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.
Selective inhibition of APOBEC3 enzymes by single-stranded DNAs containing 2'-deoxyzebularine.
Simian Immunodeficiency Virus Vif and Human APOBEC3B Interactions Resemble Those between HIV-1 Vif and Human APOBEC3G.
Single-nucleotide polymorphism of the DNA cytosine deaminase APOBEC3H haplotype I leads to enzyme destabilization and correlates with lung cancer.
Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism.
Structural Characterization of a Minimal Antibody against Human APOBEC3B.
Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation.
Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination.
Suboptimal T-cell Therapy Drives a Tumor Cell Mutator Phenotype That Promotes Escape from First-Line Treatment.
The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.
The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase.
The DNA cytosine deaminase APOBEC3B is a molecular determinant of platinum responsiveness in clear cell ovarian cancer.
The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.
The emerging role of estrogen in B cell malignancies.
The eQTL-missense polymorphisms of APOBEC3H are associated with lung cancer risk in a Han Chinese population.
The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead.
The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia.
The PKC/NF-?B signaling pathway induces APOBEC3B expression in multiple human cancers.
The rabbit as an orthologous small animal model for APOBEC3A oncogenesis.
The roles of APOBEC3B in gastric cancer.
Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes.
Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H.
Upregulation of MTA1 expression by human papillomavirus infection promotes CDDP resistance in cervical cancer cells via modulation of NF-?B/APOBEC3B cascade.
Oropharyngeal Neoplasms
APOBEC3A associates with human papillomavirus genome integration in oropharyngeal cancers.
Ovarian Neoplasms
APOBEC3B protein expression and mRNA analyses in patients with high-grade serous ovarian carcinoma.
APOBEC3B up-regulation independently predicts ovarian cancer prognosis: a cohort study.
APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.
The DNA cytosine deaminase APOBEC3B is a molecular determinant of platinum responsiveness in clear cell ovarian cancer.
Papilloma
Heat-Induced Editing of HPV Genes to Clear Mucocutaneous Warts?
Papillomavirus Infections
In vivo and in vitro studies suggest a possible involvement of HPV infection in the early stage of breast carcinogenesis via APOBEC3B induction.
Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.
The PKC/NF-?B signaling pathway induces APOBEC3B expression in multiple human cancers.
Persistent Infection
Possible footprints of APOBEC3F and/or other APOBEC3 deaminases, but not APOBEC3G, on HIV-1 from patients with acute/early and chronic infections.
Pneumonia, Pneumocystis
Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology.
Prostatic Neoplasms
Expression of DNA cytosine deaminase APOBEC3 proteins, a potential source for producing mutations, in gastric, colorectal and prostate cancers.
Retroviridae Infections
Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance.
Sialadenitis
Ductal cells of minor salivary glands in Sjögren's syndrome express LINE-1 ORF2p and APOBEC3B.
single-stranded dna cytosine deaminase deficiency
The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma.
Skin Neoplasms
A Biochemical Analysis Linking APOBEC3A to Disparate HIV-1 Restriction and Skin Cancer.
Squamous Cell Carcinoma of Head and Neck
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism.
Evidence for APOBEC3B mRNA and protein expression in oral squamous cell carcinomas.
Involvement of APOBEC3B in mutation induction by irradiation.
Multi-modality analysis supports APOBEC as a major source of mutations in head and neck squamous cell carcinoma.
Stomach Neoplasms
CagA increases DNA methylation and decreases PTEN expression in human gastric cancer.
The roles of APOBEC3B in gastric cancer.
Thrombosis
APOBEC3B up-regulation independently predicts ovarian cancer prognosis: a cohort study.
Urinary Bladder Neoplasms
Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors.
Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population.
Uterine Cervical Neoplasms
APOBEC3A possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer.
HPV-16/18 E6-induced APOBEC3B expression associates with proliferation of cervical cancer cells and hypomethylation of Cyclin D1.
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.
Identification of APOBEC3B promoter elements responsible for activation by human papillomavirus type 16 E6.
Integrated analysis reveals down-regulation of SPARCL1 is correlated with cervical cancer development and progression.
Involvement of APOBEC3B in mutation induction by irradiation.
Upregulation of MTA1 expression by human papillomavirus infection promotes CDDP resistance in cervical cancer cells via modulation of NF-?B/APOBEC3B cascade.
Viremia
APOBEC3F and APOBEC3G mRNA levels do not correlate with human immunodeficiency virus type 1 plasma viremia or CD4+ T-cell count.
Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation.
Virus Diseases
Analysis of single-nucleotide polymorphisms in the APOBEC3H gene of domestic cats (Felis catus) and their association with the susceptibility to feline immunodeficiency virus and feline leukemia virus infections.
APOBEC3B up-regulation independently predicts ovarian cancer prognosis: a cohort study.
Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses.
Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways.
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.
Hotspots for Vitamin-Steroid-Thyroid Hormone Response Elements Within Switch Regions of Immunoglobulin Heavy Chain Loci Predict a Direct Influence of Vitamins and Hormones on B Cell Class Switch Recombination.
Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.
Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.
Structural Characterization of a Minimal Antibody against Human APOBEC3B.
Wasting Syndrome
Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells.