Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.5.4.38 - single-stranded DNA cytosine deaminase and Organism(s) Bos taurus and UniProt Accession Q2PT36

for references in articles please use BRENDA:EC3.5.4.38
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme exclusively catalyses deamination of cytosine in single-stranded DNA. It preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G) . The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Bos taurus
UNIPROT: Q2PT36
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Bos taurus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
cytosine in single-stranded DNA
+
=
uracil in single-stranded DNA
+
Synonyms
apobec3b, apobec3a, apobec3f, activation-induced deaminase, apobec3h, apobec3c, apobec3d, single-stranded dna cytosine deaminase, apobec3z1, ssdna cytidine deaminase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
activation-induced deaminase
-
SYSTEMATIC NAME
IUBMB Comments
single-stranded DNA cytosine aminohydrolase
The enzyme exclusively catalyses deamination of cytosine in single-stranded DNA. It preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G) [2]. The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
cytosine in single-stranded DNA + H2O
uracil in single-stranded DNA + NH3
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Holstein Friesian cross calf
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
not detected in muscle
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
AICDA_BOVIN
199
0
24052
Swiss-Prot
Mitochondrion (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
24050
calculated from sequence
24052
x * 24052, calculated from sequence
26000
x * 26000, enzyme containing vector-encoded detection and purification tags, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Verma, S.; Goldammer, T.; Aitken, R.
Cloning and expression of activation induced cytidine deaminase from Bos taurus
Vet. Immunol. Immunopathol.
134
151-159
2010
Bos taurus (Q2PT36)
Manually annotated by BRENDA team