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Information on EC 3.5.4.31 - S-methyl-5'-thioadenosine deaminase and Organism(s) Thermotoga maritima and UniProt Accession Q9X034

for references in articles please use BRENDA:EC3.5.4.31
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IUBMB Comments
The enzyme from Thermotoga maritima also functions as S-adenosylhomocysteine deaminase (EC 3.5.4.28) and has some activity against adenosine. Adenosine 5'-phosphate and S-adenosyl-L-methionine (SAM) are not substrates.
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This record set is specific for:
Thermotoga maritima
UNIPROT: Q9X034
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The taxonomic range for the selected organisms is: Thermotoga maritima
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
tm0936, mtada, mta deaminase, pa3170, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5-methylthioadenosine deaminase
-
5-methylthioadenosine/S-adenosylhomocysteine deaminase
bifunctional enzyme EC 3.5.4.21/EC 3.5.4.28
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
S-methyl-5'-thioadenosine amidohydrolase
The enzyme from Thermotoga maritima also functions as S-adenosylhomocysteine deaminase (EC 3.5.4.28) and has some activity against adenosine. Adenosine 5'-phosphate and S-adenosyl-L-methionine (SAM) are not substrates.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
adenosine + H2O
inosine + NH3
show the reaction diagram
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5'-thioinosine + NH3
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-methyl-5'-thioadenosine + H2O
S-methyl-5'-thioinosine + NH3
show the reaction diagram
-
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.25
adenosine
pH and temperature not specified in the publication
0.044
S-methyl-5'-thioadenosine
pH and temperature not specified in the publication
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.3
adenosine
pH and temperature not specified in the publication
7.2
S-methyl-5'-thioadenosine
pH and temperature not specified in the publication
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
9.2
adenosine
pH and temperature not specified in the publication
140
S-methyl-5'-thioadenosine
pH and temperature not specified in the publication
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
X-ray crystal structure of the complex between Tm0936 and the product resulting from the deamination of SAH, S-inosylhomocysteine
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hermann, J.C.; Marti-Arbona, R.; Fedorov, A.A.; Fedorov, E.; Almo, S.C.; Shoichet, B.K.; Raushel, F.M.
Structure-based activity prediction for an enzyme of unknown function
Nature
448
775-779
2007
Thermotoga maritima (Q9X034), Thermotoga maritima
Manually annotated by BRENDA team