Information on EC 3.5.4.24 - sepiapterin deaminase

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The expected taxonomic range for this enzyme is: Bombyx mori

EC NUMBER
COMMENTARY hide
3.5.4.24
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RECOMMENDED NAME
GeneOntology No.
sepiapterin deaminase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
sepiapterin + H2O = xanthopterin-B2 + NH3
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amidine hydrolysis
-
-
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SYSTEMATIC NAME
IUBMB Comments
sepiapterin aminohydrolase
Also acts on isosepiapterin, but more slowly.
CAS REGISTRY NUMBER
COMMENTARY hide
62213-22-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
isosepiapterin + H2O
?
show the reaction diagram
sepiapterin + H2O
xanthopterin-B2 + NH3
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
sepiapterin + H2O
xanthopterin-B2 + NH3
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,4-Dihydroxypteridine
-
0.2 mM, 15% inhibition
2-Amino-4-hydroxypteridine
2-amino-4-hydroxypteridine-6-carboxylic acid
-
0.2 mM, 26% inhibition
8-Azaguanine
-
competitive inhibition
adenine
-
0.2 mM, 27% inhibition
aminopterin
biopterin
-
most effective inhibitor, 0.2 mM, 84% inhibition
guanine
-
0.2 mM, 59% inhibition
methopterin
-
competitive inhibition
p-chloromercuribenzoate
phenyl methyl sulfonylfluoride
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-
pterin
-
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uric acid
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0.2 mM, 9% inhibition
Xanthopterin
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.59
sepiapterin
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2.15
-
-
178.8
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 10
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
granule membrane, pteridine granule in the epidermal cells
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70000
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gel filtration
74000
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SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
-
1 * 74000, SDS-PAGE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
3°C 15% decrease in enzyme activity after 1 month
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
mutant lemon, normal type
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