Reference on EC 3.5.4.2 - adenine deaminase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nolan, L.L.; Kidder, G.W.
Inhibition of growth and purine-metabolizing enzymes of trypanosomid flagellates by N6-methyladenine
Antimicrob. Agents Chemother.
17
567-571
1980
Crithidia fasciculata, Leishmania braziliensis, Leishmania mexicana, Trypanosoma cruzi, Oryctolagus cuniculus, plant
Jun, H.K.; Park, J.H.
Exogenous adenine deaminase production by Streptomyces sp. J-350P
Korean J. Appl. Microbiol. Bioeng.
12
31-36
1984
Streptomyces sp., Streptomyces sp. J-350P
-
Allam, A.M.; Elawamry, Z.A.; Elzainy, T.A.
Discrete activities for adenine and adenosine deaminations in extracts of Streptomyces viridiviolaceus
Egypt. J. Bot.
24
149-152
1981
Streptomyces viridiviolaceus
-
Kidder, G.W.; Nolan, L.L.
Adenine aminohydrolase: occurrence and possible significance in trypanosomid flagellates
Proc. Natl. Acad. Sci. USA
76
3670-3672
1979
BRENDA: Crithidia fasciculata, Leishmania braziliensis, Leishmania donovani, Leishmania mexicana, Leishmania tarentolae
Textmining: Leishmania
Kidder, G.W.; Dewey, V.C.; Nolan, L.L.
Adenine deaminase of a eukaryotic animal cell, Crithidia fasciculata
Arch. Biochem. Biophys.
183
7-12
1977
BRENDA: Crithidia fasciculata
Textmining: animal
Jun, H.K.; Sakai, T.
Some properties of adenine deaminase of Pseudomonas synxantha
J. Ferment. Technol.
57
294-299
1979
Pseudomonas synxantha, Pseudomonas synxantha A3
-
Sakai, T.; Jun, H.K.
Purification and characterisation of adenine deaminase in Pseudomonas synxantha
J. Ferment. Technol.
56
257-265
1978
Pseudomonas synxantha, Pseudomonas synxantha A3
-
Zielke, C.L.; Suelter, C.H.
Purine, purine nucleoside, and purine nucleotide aminohydrolases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
4
47-78
1971
Cyberlindnera jadinii
-
Heppel, L.A.; Hurwitz, J.; Horecker, B.L.
Adenine deaminase of Azobacter vinelandii
J. Am. Chem. Soc.
79
630-633
1957
Azotobacter vinelandii
-
Abbondandolo, A.; Weyer, A.; Heslot, H.; Lambert, M.
Study of adenine aminohydrolase in the yeast, Schizosaccharomyces pombe
J. Bacteriol.
108
959-963
1971
BRENDA: Schizosaccharomyces pombe
Textmining: Saccharomyces cerevisiae
Deeley, M.C.
Adenine deaminase and adenine utilization in Saccharomyces cerevisiae
J. Bacteriol.
174
3102-3110
1992
BRENDA: Saccharomyces cerevisiae
Textmining: Escherichia coli
Nygaard, P.; Duckert, P.; Saxild, H.H.
Role of adenine deaminase in purine salvage and nitrogen metabolism and characterisation of the ade gene in Bacillus subtilis
J. Bacteriol.
178
846-853
1996
Bacillus subtilis
Hassan, H.F.; Coombs, G.H.
Leishmania mexicana: purine-metabolizing enzymes of amastigotes and promastigotes
Exp. Parasitol.
59
139-150
1985
Machaerocera mexicana, Leishmania mexicana, Leishmania mexicana mexicana
Canale-Parola, E.; Kidder, G.W.
Enzymatic activities for interconversion of purines in spirochetes
J. Bacteriol.
152
1105-1110
1982
Treponema succinifaciens, Spirochaetales, Spirochaeta aurantia, Treponema stenostreptum, Treponema denticola
Matsui, H.; Shimaoka, M.; Kawasaki, H.; Takenaka, Y.; Kurahashi, O.
Adenine deaminase activity of the yicP gene product of Escherichia coli
Biosci. Biotechnol. Biochem.
65
1112-1118
2001
BRENDA: Escherichia coli
Textmining: Bacillus subtilis
Ribard, C.; Rochet, M.; Labedan, B.; Daignan-Fornier, B.; Alzari, P.; Scazzocchio, C.; Oestreicher, N.
Sub-families of alpha/beta barrel enzymes: a new adenine deaminase family
J. Mol. Biol.
334
1117-1131
2003
BRENDA: Aspergillus nidulans (Q8X1T6), Aspergillus nidulans
Textmining: eukaryota, Escherichia coli, Ascomycota, Schizosaccharomyces pombe, Saccharomyces cerevisiae
Katahira, R.; Ashihara, H.
Profiles of purine biosynthesis, salvage and degradation in disks of potato (Solanum tuberosum L.) tubers
Planta
225
115-126
2006
Solanum tuberosum, Tuber
Dorgan, K.M.; Wooderchak, W.L.; Wynn, D.P.; Karschner, E.L.; Alfaro, J.F.; Cui, Y.; Zhou, Z.S.; Hevel, J.M.
An enzyme-coupled continuous spectrophotometric assay for S-adenosylmethionine-dependent methyltransferases
Anal. Biochem.
350
249-255
2006
Rattus
Boitz, J.M.; Ullman, B.
Leishmania donovani singly deficient in HGPRT, APRT or XPRT are viable in vitro and within mammalian macrophages
Mol. Biochem. Parasitol.
148
24-30
2006
Leishmania donovani
Escusa, S.; Camblong, J.; Galan, J.M.; Pinson, B.; Daignan-Fornier, B.
Proteasome- and SCF-dependent degradation of yeast adenine deaminase upon transition from proliferation to quiescence requires a new F-box protein named Saf1p
Mol. Microbiol.
60
1014-1025
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Oestreicher, N.; Ribard, C.; Scazzocchio, C.
The nadA gene of Aspergillus nidulans, encoding adenine deaminase, is subject to a unique regulatory pattern
Fungal Genet. Biol.
45
760-775
2008
Aspergillus nidulans
McLean, S.; Hunter, C.N.
An enzyme-coupled continuous spectrophotometric assay for magnesium protoporphyrin IX methyltransferases
Anal. Biochem.
394
223-228
2009
Synechocystis sp.
Pospisilova, H.; Sebela, M.; Novak, O.; Frebort, I.
Hydrolytic cleavage of N6-substituted adenine derivatives by eukaryotic adenine and adenosine deaminases
Biosci. Rep.
28
335-347
2008
BRENDA: Saccharomyces cerevisiae, Saccharomyces cerevisiae (P53909), Schizosaccharomyces pombe, Schizosaccharomyces pombe (Q9P6I7)
Textmining: Escherichia coli, Arabidopsis thaliana, Arabidopsis thaliana (Q8LPL7), yeasts, Homo sapiens, plant
Kamat, S.S.; Bagaria, A.; Kumaran, D.; Holmes-Hampton, G.P.; Fan, H.; Sali, A.; Sauder, J.M.; Burley, S.K.; Lindahl, P.A.; Swaminathan, S.; Raushel, F.M.
Catalytic mechanism and three-dimensional structure of adenine deaminase
Biochemistry
50
1917-1927
2011
BRENDA: Escherichia coli
Textmining: Agrobacterium tumefaciens, Chelator, Electron
Goble, A.; Zhang, Z.; Sauder, J.; Burley, S.; Swaminathan, S.; Raushel, F.
Pa0148 from Pseudomonas aeruginosa catalyzes the deamination of adenine
Biochemistry
50
6589-6597
2011
Paenarthrobacter aurescens, Burkholderia sp., Pseudomonas aeruginosa, Alteromonas macleodii
Bell, L.; Bitencourt, P.; Abdalla, F.; Guerra, R.; Funchal, C.; Moretto, M.
An in vitro comparison of a new vinyl chalcogenide and sodium selenate on adenosine deaminase activity of human leukocytes
Chem. Biol. Interact.
189
141-145
2011
Homo sapiens
Boitz, J.M.; Strasser, R.; Hartman, C.U.; Jardim, A.; Ullman, B.
Adenine aminohydrolase from Leishmania donovani: unique enzyme in parasite purine metabolism
J. Biol. Chem.
287
7626-7639
2012
BRENDA: Leishmania donovani
Textmining: Leishmania, Homo sapiens, Saccharomyces cerevisiae, Mus musculus, Mus sp.
Boitz, J.M.; Ullman, B.
Amplification of adenine phosphoribosyltransferase suppresses the conditionally lethal growth and virulence phenotype of Leishmania donovani mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases
J. Biol. Chem.
285
18555-18564
2010
Leishmania donovani
Kamat, S.S.; Holmes-Hampton, G.P.; Bagaria, A.; Kumaran, D.; Tichy, S.E.; Gheyi, T.; Zheng, X.; Bain, K.; Groshong, C.; Emtage, S.; Sauder, J.M.; Burley, S.K.; Swaminathan, S.; Lindahl, P.A.; Raushel, F.M.
The catalase activity of diiron adenine deaminase
Protein Sci.
20
2080-2094
2011
Escherichia coli, Chelator
Jankowska, D.A.; Faulwasser, K.; Trautwein-Schult, A.; Cordes, A.; Hoferichter, P.; Klein, C.; Bode, R.; Baronian, K.; Kunze, G.
Arxula adeninivorans recombinant adenine deaminase and its application in the production of food with low purine content
J. Appl. Microbiol.
115
1134-1146
2013
Blastobotrys adeninivorans (L8BT48), Blastobotrys adeninivorans, Blastobotrys adeninivorans LS3 (L8BT48)
Mahor, D.; Prasad, G.S.
Biochemical characterization of Kluyveromyces lactis adenine deaminase and guanine deaminase and their potential application in lowering purine content in beer
Front. Bioeng. Biotechnol.
6
180
2018
Kluyveromyces lactis, Kluyveromyces lactis MTCC 458
Miller, D.; Brown, A.; Xu, H.; Bevan, D.; White, R.
Purine salvage in Methanocaldococcus jannaschii Elucidating the role of a conserved cysteine in adenine deaminase
Proteins
84
828-840
2016
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661
Boitz, JM; Strasser, R; Yates, PA; Jardim, A; Ullman, B
Adenylosuccinate Synthetase and Adenylosuccinate Lyase Deficiencies Trigger Growth and Infectivity Deficits in Leishmania donovani.
J Biol Chem
288
8977-90
2013
Leishmania donovani
Zernik, J; Thiede, MA; Twarog, K; Stover, ML; Rodan, GA; Upholt, WB; Rowe, DW
Cloning and analysis of the 5' region of the rat bone/liver/kidney/placenta alkaline phosphatase gene. A dual-function promoter.
Matrix
10
38-47
1990
Rattus, Homo sapiens, Mus musculus
Sokovnina, IaM; Debov, SS; Iakovleva, LA; Tskhakaia, NA
[Thrombocyte adenase of healthy monkeys and monkeys with different degrees of hemoblastosis]
Biull Eksp Biol Med
84
555-6
1977
Platyrrhini
Sokovnina, IaM; Tentsova, IA; Debov, SS
[Adenase inhibitor in thrombocytes of healthy humans]
Vopr Med Khim
425-7
0
Homo sapiens
Sokovnina, IaM; Debov, SS
[Adenase of formed elements of blood of donors and of patients with different blood diseases]
Vopr Med Khim
22
117-9
0
Homo sapiens
Mardashev, SR; Sokovnina, IaM
[Adenase activity in animal tissues]
Biull Eksp Biol Med
79
32-4
1975
animal
Sokovnina, IaM; Guseva, MK; Anikeĭcheva, NV
[Properties of E. coli adenine aminohydrolase]
Biull Eksp Biol Med
92
42-4
1981
Escherichia coli
Cook, PC; Jiang, S; Chertkov, JL; Fan, Y; Levere, RD; Abraham, NG
Transfer of human adenine deaminase gene into murine hematopoietic stem cells: sequential study of spleen colony-forming units from bone marrow of living mice and the requirement of the microenvironment.
Acta Haematol
96
57-63
1996
Homo sapiens, Mus musculus, Mus sp.
Petersen, C; Møller, LB; Valentin-Hansen, P
The cryptic adenine deaminase gene of Escherichia coli. Silencing by the nucleoid-associated DNA-binding protein, H-NS, and activation by insertion elements.
J Biol Chem
277
31373-80
2002
Escherichia coli, insertion sequences
ROUSH, AH
Yeast adenase.
Arch Biochem Biophys
50
510-2
1954
Saccharomyces cerevisiae
ROUSH, AH; SAEED, M
Adenine metabolism in Saccharomyces cerevisiae adenase from bakers' yeast.
Biochem Biophys Res Commun
2
43-7
1960
Saccharomyces cerevisiae
Fu, K; Fan, L; Yu, C; Li, Y; Gao, S; Li, Y; Chen, J
Adenine deaminase is encoded by Tad1 and participates in copper accumulation in Trichoderma reesei.
Fungal Genet Biol
63
17-23
2014
Trichoderma reesei
Bottari, NB; Baldissera, MD; Tonin, AA; Frana, RT; Zanini, D; Leal, ML; Lopes, ST; Schetinger, MR; Morsch, VM; Monteiro, SG; Guarda, NS; Moresco, RN; Aires, AR; Stefani, LM; Da Silva, AS
Effects of iron supplementation on blood adenine deaminase activity and oxidative stress in Trypanosoma evansi infection of rats.
Exp Parasitol
147
1-6
2014
Trypanosoma evansi, Rattus, Metazoa
Hoang, T; Bergeron, M
Adenosine deaminase in renal ontogeny and compensatory hypertrophy in the rat.
Cell Tissue Kinet
16
59-64
1983
Rattus
Sahota, A; Ranjekar, PK; Alfonzo, J; Lewin, AS; Taylor, MW
Mutants of Saccharomyces cerevisiae deficient in adenine phosphoribosyltransferase.
Mutat Res
180
81-7
1987
Saccharomyces cerevisiae
Woods, RA; Roberts, DG; Stein, DS; Filpula, D
Adenine phosphoribosyltransferase mutants in Saccharomyces cerevisiae.
J Gen Microbiol
130
2629-37
1984
Saccharomyces cerevisiae
Green, RD
Adenosine transport by a variant of C1300 murine neuroblastoma cells deficient in adenosine kinase.
Biochim Biophys Acta
598
366-74
1980
Mus musculus
Hassan, HF; Coombs, GH
Purine-metabolising enzymes in Entamoeba histolytica.
Mol Biochem Parasitol
19
19-26
1986
Entamoeba histolytica
Davis, JW; Nelson, P; Ranglin, R
Enzyme activities contributing to hypoxanthine production in Ureaplasma.
Isr J Med Sci
20
946-9
1984
Ureaplasma, Mycoplasmatales, Ureaplasma urealyticum
Pechánová, O; Babál, P
Activity of some adenine nucleotide degradation enzymes in human atherosclerotic aorta endothelium.
Folia Biol (Praha)
39
188-94
1993
Homo sapiens
Guranowski, A; Wasternack, C
Adenine and adenosine metabolizing enzymes in cell-free extracts from Euglena gracilis.
Comp Biochem Physiol B
71
483-8
1982
Euglena gracilis, Euglena, Metazoa
Bongaerts, GP; Sin, IL; Peters, AL; Vogels, GD
Purine degradation in Pseudomonas aeruginosa and Pseudomonas testosteroni.
Biochim Biophys Acta
499
111-8
1977
Comamonas testosteroni, Pseudomonas aeruginosa
Marr, JJ; Berens, RL; Nelson, DJ
Purine metabolism in Leishmania donovani and Leishmania braziliensis.
Biochim Biophys Acta
544
360-71
1978
Leishmania braziliensis, Leishmania donovani, Leishmania, Transformation
Yabuki, N; Ashihara, H
Catabolism of adenine nucleotides in suspension-cultured plant cells.
Biochim Biophys Acta
1073
474-80
1991
plant, Catharanthus roseus
Davies, MJ; Ross, AM; Gutteridge, WE
The enzymes of purine salvage in Trypanosoma cruzi, Trypanosoma brucei and Leishmania mexicana.
Parasitology
87 (Pt 2)
211-7
1983
Leishmania mexicana, Trypanosoma brucei, Trypanosoma cruzi
Kocharian, ShM; Kocharian, AM; Meliksetian, GO; Akopian, ZhI
[Escherichia coli K-12 mutants assimilating adenine via a new metabolic pathway]
Genetika
18
906-15
1982
Escherichia coli
Scazzocchio, C; Sdrin, N; Ong, G
Positive regulation in a eukaryote, a study of the uaY gene of Aspergillus nidulans: I. Characterization of alleles, dominance and complementation studies, and a fine structure map of the uaY--oxpA cluster.
Genetics
100
185-208
1982
Aspergillus nidulans
Li, YL; He, RR
Endogenous adenosine and ATP-sensitive potassium channel modulate anoxia-induced electrophysiological changes of pacemaker cells in sinoatrial node of guinea pigs.
Zhongguo Yao Li Xue Bao
16
42-6
1995
Anoxia
Alleman, MM; Gottlieb, M
Enhanced acquisition of purine nucleosides and nucleobases by purine-starved Crithidia luciliae.
Mol Biochem Parasitol
76
279-87
0
Crithidia luciliae
Koz'min, SG; Domkin, VD; Zekhnov, AM; Pavlov, IuI
[Genetic control of metabolism of a mutagenic analog of 6-N-hydroxylaminopurine bases in Saccharomyces cerevisiae yeasts]
Genetika
33
591-8
1997
Saccharomyces cerevisiae
Kloepfer, JA; Mielke, RE; Nadeau, JL
Uptake of CdSe and CdSe/ZnS quantum dots into bacteria via purine-dependent mechanisms.
Appl Environ Microbiol
71
2548-57
2005
Bacillus subtilis
Jewett, MW; Lawrence, K; Bestor, AC; Tilly, K; Grimm, D; Shaw, P; VanRaden, M; Gherardini, F; Rosa, PA
The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi.
Mol Microbiol
64
1358-74
2007
Spirochaetales
Boitz, JM; Ullman, B
Adenine and adenosine salvage in Leishmania donovani.
Mol Biochem Parasitol
190
51-5
2013
Leishmania, Leishmania donovani
Ryu, SM; Koo, T; Kim, K; Lim, K; Baek, G; Kim, ST; Kim, HS; Kim, DE; Lee, H; Chung, E; Kim, JS
Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy.
Nat Biotechnol
36
536-539
2018
Streptococcus pyogenes
Escusa, S; Laporte, D; Massoni, A; Boucherie, H; Dautant, A; Daignan-Fornier, B
Skp1-Cullin-F-box-dependent degradation of Aah1p requires its interaction with the F-box protein Saf1p.
J Biol Chem
282
20097-103
2007
Saccharomyces cerevisiae
Butt, F; Yasinzai, M; Malik, SI; Munir, A
Isolation and Characterization of Leishmanial Adenine Aminohydrolase as a Drug target.
Curr Comput Aided Drug Des
2020
Leishmania
Ogbunude, PO; Ikediobi, CO
Comparative aspects of purine metabolism in some African trypanosomes.
Mol Biochem Parasitol
9
279-87
1983
Trypanosoma brucei, Trypanosoma vivax, Trypanosoma congolense
Krasuski, A; Galiński, J; Smoleński, RT; Marlewski, M
[Deamination of adenine and adenosine in staphylococci]
Med Dosw Mikrobiol
49
113-22
1997
Staphylococcus intermedius
Becerra, A; Lazcano, A
The role of gene duplication in the evolution of purine nucleotide salvage pathways.
Orig Life Evol Biosph
28
539-53
1998
Archaea
Feliu, MS; Slobodianik, NH
Potential markers of the nutritional status in an experimental model.
Nutrition
16
1082-3
0
Homo sapiens, Rattus, Rattus norvegicus
Pospisilova, H; Frebort, I
Aminohydrolases acting on adenine, adenosine and their derivatives.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
151
3-10
2007
Ascomycota, Homo sapiens
O'Connell, MA; Mannion, NM; Keegan, LP
The Epitranscriptome and Innate Immunity.
PLoS Genet
11
e1005687
2015
Homo sapiens
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