Information on EC 3.5.4.18 - ATP deaminase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
3.5.4.18
-
RECOMMENDED NAME
GeneOntology No.
ATP deaminase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O = ITP + NH3
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of amidines
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP aminohydrolase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37289-21-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
red marine alga
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3',5'-cyclic AMP + H2O
?
show the reaction diagram
3'-AMP + H2O
3'-IMP + NH3
show the reaction diagram
5'-adenosine acetate + H2O
5'-inosine acetate + NH3
show the reaction diagram
-
-
-
-
?
5'-adenosine propionate + H2O
5'-inosine propionate
show the reaction diagram
-
-
-
-
?
6-chloropurine riboside + H2O
inosine + HCl
show the reaction diagram
-
-
-
-
?
adenosine + H2O
inosine + NH3
show the reaction diagram
adenosine 5'-monosulfate + H2O
inosine 5'-monosulfate + NH3
show the reaction diagram
-
-
-
-
?
adenosine 5'-tetraphosphate + H2O
inosine 5'-tetraphosphate + NH3
show the reaction diagram
ADP + H2O
IDP + NH3
show the reaction diagram
ADP-glucose + H2O
IDP-glucose + NH3
show the reaction diagram
ADPribose + H2O
IDPribose + NH3
show the reaction diagram
AMP + H2O
IMP + NH3
show the reaction diagram
ATP + H2O
ITP + NH3
show the reaction diagram
CoA + H2O
?
show the reaction diagram
dADP + H2O
dIDP + NH3
show the reaction diagram
dAMP + H2O
dIMP + NH3
show the reaction diagram
dATP + H2O
dITP + NH3
show the reaction diagram
deoxyadenosine + H2O
deoxyinosine + NH3
show the reaction diagram
-
-
-
-
?
FAD + H2O
?
show the reaction diagram
NAD+ + H2O
inosine nicotinamide dinucleotide + NH3
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O
ITP + NH3
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
divalent cations, Mg2+, Ba2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
beta,beta-dimethyl glutarate
-
3,2 mM
cacodylate
-
134 mM
Mg2+
-
5 mM, 17% inhibition of bound enzyme, no inhibition of free enzyme
p-chloromercuribenzoate
phosphate
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.1
6-Chloropurine riboside
-
-
0.5 - 0.69
adenosine
0.05 - 0.25
AMP
0.02 - 0.83
ATP
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3
-
bound enzyme
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40
-
free and bound enzyme
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0 - 50
-
bound enzyme
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, pH5, 25 days
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE