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Information on EC 3.5.4.1 - cytosine deaminase and Organism(s) Mus musculus and UniProt Accession Q99J72

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EC Tree
     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.1 cytosine deaminase
IUBMB Comments
Also acts on 5-methylcytosine.
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This record set is specific for:
Mus musculus
UNIPROT: Q99J72
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
apobec3g, apobec3, cytosine deaminase, apobec1, zn2+cdase, fca1p, isocytosine deaminase, coda protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cytosine aminohydrolase
-
-
-
-
isocytosine deaminase
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
cytosine aminohydrolase
Also acts on 5-methylcytosine.
CAS REGISTRY NUMBER
COMMENTARY hide
9025-05-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
for woodchuck hepatitis virus mAPOBEC3 is operative
physiological function
mHBV (mouse transgenic model of HBV replication) is edited in vivo by mAPOBEC1 (mA1) and not mAPOBEC3
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ABEC3_MOUSE
440
0
52213
Swiss-Prot
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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inhibition of tumor growth in mice treated with gene transfer of interleukin IL-12 plus enzyme/5-fluorcytosine is significantly greater than in mice treated with enzyme or IL-12 alone. Combined gene transfer increases splenic natural killer cell activity and interferon-gamma production by slenocytes and increases tumor growth inhibition and mean animal survival time
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hwang, K.; Cho, W.; Yoo, J.; Yun, H.; Kim, S.; Im, D.
Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice
BMC Cancer
5
51
2005
Mus musculus
Manually annotated by BRENDA team
Renard, M.; Henry, M.; Guetard, D.; Vartanian, J.P.; Wain-Hobson, S.
APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo
J. Mol. Biol.
400
323-334
2010
Mus musculus (P51908), Mus musculus (Q99J72), Mus musculus
Manually annotated by BRENDA team