Arginine, N2-acetylarginine and N2-glutamylarginine do not act as substrates . This is the second enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine . This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 188.8.131.52 (arginine N-succinyltransferase), EC 184.108.40.206 (N-succinylarginine dihydrolase), EC 220.127.116.11 (succinylornithine transaminase), EC 18.104.22.168 (succinylglutamate semialdehyde dehydrogenase) and EC 22.214.171.124 (succinylglutamate desuccinylase).
immunization of mice with recombinant succinylarginine dihydrolase with a peptide sequence similar to an anti-prion epitope, induces anti-PrP auto-Abs with anti-prion activity and significantly retards survival times of the mice subsequently infected with Fukuoka-1 prions