Reference on EC 3.5.2.9 - 5-oxoprolinase (ATP-hydrolysing)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hsu, T.; Meister, A.
Metabolism in vivo of 5-oxo-L-proline and its inhibition by analogs of 5-oxo-L-proline
Methods Enzymol.
113
468-471
1985
Mus musculus, Rattus norvegicus, Mus musculus NCS
Seddon, A.P.; Li, L.; Meister, A.
5-Oxo-L-prolinase from Pseudomonas putida
Methods Enzymol.
113
451-458
1985
Pseudomonas putida, Rattus norvegicus, Pseudomonas putida ALA
Meister, A.; Griffith, O.W.; Williamson, J.M.
5-Oxo-L-Prolinase from rat kidney
Methods Enzymol.
113
445-451
1985
BRENDA: Rattus norvegicus
Textmining: Rattus
Seddon, A.P.; Li, L.; Meister, A.
Resolution of 5-oxo-L-prolinase into a 5-oxo-L-proline-dependent ATPase and a coupling protein
J. Biol. Chem.
259
8091-8094
1984
Pseudomonas putida, Rattus norvegicus
Williamson, J.M.; Meister, A.
New substrates of 5-oxo-L-prolinase
J. Biol. Chem.
257
12039-12042
1982
Mus musculus, Rattus norvegicus
Williamson, J.M.; Meister, A.
Effect of sulfhydryl group modification on the activities of 5-oxo-L-prolinase
J. Biol. Chem.
257
9161-9172
1982
BRENDA: Rattus norvegicus
Textmining: Rattus
Griffith, O.W.; Meister, A.
Interaction of 5-oxo-L-prolinase with nucleoside triphosphates. Evidence suggesting substrate-dependent conformational change
J. Biol. Chem.
257
4392-4397
1982
Rattus norvegicus
Griffith, O.W.; Meister, A.
5-Oxo-L-prolinase (L-pyroglutamate hydrolase). Studies of the chemical mechanism
J. Biol. Chem.
256
9981-9985
1981
BRENDA: Rattus norvegicus
Textmining: Rattus
Tsui, E.; Yeung, A.
Development of gamma-glutamylcysteine synthetase and oxoprolinase in rat kidney
Experientia
35
1293-1295
1979
BRENDA: Rattus norvegicus, Rattus norvegicus Wistar albino
Textmining: Rattus
Mazelis, M.; Creveling, R.G.
5-Oxoprolinase (L-pyroglutamate hydrolase) in higher plants
Plant Physiol.
62
798-801
1978
BRENDA: Brassica oleracea, Brassica rapa, Cucurbita pepo, Daucus carota, Pisum sativum, Pseudomonas sp., Raphanus sativus, Rattus norvegicus, Solanum tuberosum, Spinacia oleracea, Triticum aestivum
Textmining: Embryophyta
Griffith, O.W.; Meister, A.
Dependence of energy coupling on nucleotide base structure in the reaction catalyzed by 5-oxo-L-prolinase
Biochem. Biophys. Res. Commun.
70
759-765
1976
Rattus norvegicus
Van Der Werf, P.; Griffith, O.W.; Meister, A.
5-Oxo-L-prolinase (L-pyroglutamate hydrolase) purification and catalytic properties
J. Biol. Chem.
250
6686-6692
1975
BRENDA: Bos taurus, Canis lupus familiaris, Felis catus, Mus musculus, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus, Rattus norvegicus Sprague-Dawley, Sus scrofa
Textmining: Rattus
Wendel, A.; Flugge, U.J.
5-Oxoprolinase from rat kidney, I assay, purification, and determination of kinetic parameters
Hoppe-Seyler's Z. Physiol. Chem.
356
873-880
1975
BRENDA: Mus musculus, Rattus norvegicus
Textmining: Rattus
Wendel, A.; Flugge, U.J.; Jenke, H.S.
5-Oxoprolinase from rat kidney, II molecular weight determinations
Hoppe-Seyler's Z. Physiol. Chem.
356
881-885
1975
BRENDA: Rattus norvegicus
Textmining: Rattus
Van Der Werf, P.; Stephani, R.A.; Meister, A.
Accumulation of 5-oxoproline in mouse tissues after inhibition of 5-oxoprolinase and administration of amino acids: Evidence for function of the gamma-glutamyl cycle
Proc. Natl. Acad. Sci. USA
71
1026-1029
1974
Homo sapiens, Mus musculus, Pseudomonas sp., Rattus norvegicus
Van Der Werf, P.; Meister, A.
Isolation of 5-oxoprolinase from a prokaryote
Biochem. Biophys. Res. Commun.
56
90-96
1974
BRENDA: Mus musculus, Pseudomonas sp., Rattus norvegicus
Textmining: Bacteria
Van Der Werf, P.; Stephani, R.A.; Orlowski, M.; Meister, A.
Inhibition of 5-oxoprolinase by 2-imidazolidone-4-carboxylic acid
Proc. Natl. Acad. Sci. USA
70
759-761
1973
Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Van Der Werf, P.; Orlowski, M.; Meister, A.
Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the gamma-glutamyl cycle
Proc. Natl. Acad. Sci. USA
68
2982-2985
1971
Ovis aries, Homo sapiens, Rattus norvegicus, Sus scrofa
Ye, G.J.; Breslow, E.; Meister, A.
The amino acid sequence of rat kidney 5-oxo-L-prolinase determined by cDNA cloning
J. Biol. Chem.
271
32293-32300
1996
BRENDA: Pseudomonas putida, Rattus norvegicus (P97608)
Textmining: Rattus
Srivenugopal, K.S.; Ali-Osman, F.
Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues
Cancer Lett.
117
105-111
1997
Homo sapiens
Chen, X.; Schecter, R.L.; Griffith, O.W.; Hayward, M.A.; Alpert, L.C.; Batist, G.
Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: A potential new target for biochemical modulation of glutathione
Clin. Cancer Res.
4
131-138
1998
BRENDA: Homo sapiens, Rattus norvegicus
Textmining: Rattus, Oryctolagus cuniculus
Chen, X.; Batist, G.
Sensitization effect of L-2-oxothiazolidine-4-carboxylate on tumor cells to melphalan and the role of 5-oxo-L-prolinase in glutathione modulation in tumor cells
Biochem. Pharmacol.
56
743-749
1998
BRENDA: Homo sapiens
Textmining: Rattus
Jaeger, M.; Weber, P.; Wolf, S.
Immunohistochemical localization of 5-oxo-L-prolinase, an enzyme of the gamma-glutamyl cycle, in porcine brain microvessels
FEBS Lett.
445
215-217
1999
Sus scrofa
Weber, P.; Jaeger, M.; Bangsow, T.; Knell, G.; Piechaczek, K.; Koch, J.; Wolf, S.
Kinetic parameters and tissue distribution of 5-oxo-L-prolinase determined by a fluorimetric assay
J. Biochem. Biophys. Methods
38
71-82
1999
Rattus norvegicus, Sus scrofa
Mochizuki, K.
Purification and characterization of 5-oxo-L-prolinase from Paecilomyces varioti F-1, an ATP-dependent hydrolase active with L-2-oxothiazolidine-4-carboxylic acid
Arch. Microbiol.
172
182-185
1999
BRENDA: Alcaligenes sp., Paecilomyces variotii, Pseudomonas putida, Rattus norvegicus, Paecilomyces variotii F-1, Alcaligenes sp. F-137
Textmining: Paecilomyces
Watanabe, T.; Abe, K.; Ishikawa, H.; Iijima, Y.
Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery
Biol. Pharm. Bull.
27
288-294
2004
BRENDA: Bos taurus (Q75WB5), Bos taurus
Textmining: Rattus, Canis lupus familiaris
Ruijter, G.J.; Mourad-Baars, P.E.; Ristoff, E.; Onkenhout, W.; Poorthuis, B.J.
Persistent 5-oxoprolinuria with normal glutathione synthase and 5-oxoprolinase activities
J. Inherit. Metab. Dis.
29
587
2006
Homo sapiens
Ohkama-Ohtsu, N.; Oikawa, A.; Zhao, P.; Xiang, C.; Saito, K.; Oliver, D.J.
A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis
Plant Physiol.
148
1603-1613
2008
BRENDA: Arabidopsis thaliana (Q9FIZ7)
Textmining: Arabidopsis, Mammalia
Kaufmann, Y.; Todorova, V.K.; Luo, S.; Klimberg, V.S.
Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model
Nutr. Cancer
60
518-525
2008
BRENDA: Rattus norvegicus
Textmining: Rattus
Kumar, A.; Bachhawat, A.K.
A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?
J. Biosci.
35
21-25
2010
Homo sapiens
Kumar, A.; Bachhawat, A.K.
OXP1/YKL215c encodes an ATP-dependent 5-oxoprolinase in Saccharomyces cerevisiae: functional characterization, domain structure and identification of actin-like ATP-binding motifs in eukaryotic 5-oxoprolinases
FEMS Yeast Res.
10
394-401
2010
Saccharomyces cerevisiae (P28273), Saccharomyces cerevisiae
Almaghlouth, I.; Mohamed, J.; Al-Amoudi, M.; Al-Ahaidib, L.; Al-Odaib, A.; Alkuraya, F.
5-Oxoprolinase deficiency: report of the first human OPLAH mutation
Clin. Genet.
82
193-196
2012
Homo sapiens (O14841), Homo sapiens
Calpena, E.; Deshpande, A.A.; Yap, S.; Kumar, A.; Manning, N.J.; Bachhawat, A.K.; Espinos, C.
New insights into the genetics of 5-oxoprolinase deficiency and further evidence that it is a benign biochemical condition
Eur. J. Pediatr.
174
407-411
2015
Homo sapiens (O14841), Homo sapiens
Vetter, A.M.; Helmecke, J.; Schomburg, D.; Neumann-Schaal, M.
The impact of pyroglutamate Sulfolobus acidocaldarius has a growth advantage over Saccharolobus solfataricus in glutamate-containing media
Archaea
2019
3208051
2019
BRENDA: Sulfolobus acidocaldarius (Q4JBP4), Sulfolobus acidocaldarius, Saccharolobus solfataricus (Q97XP4), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97XP4), Sulfolobus acidocaldarius DSM 639 (Q4JBP4), Saccharolobus solfataricus JCM 11322 (Q97XP4), Saccharolobus solfataricus ATCC 35092 (Q97XP4), Sulfolobus acidocaldarius ATCC 33909 (Q4JBP4), Saccharolobus solfataricus DSM 1617 (Q97XP4), Sulfolobus acidocaldarius NBRC 15157 (Q4JBP4), Sulfolobus acidocaldarius NCIMB 11770 (Q4JBP4), Sulfolobus acidocaldarius JCM 8929 (Q4JBP4)
Textmining: Sulfolobaceae
Oke, M.; Oni, O.; Bello, R.; Samuel-Omoyajowo, K.; Senbadejo, T.
Structure-function relationships of the 5-oxoprolinase subunit A guiding biological sciences students down the path less traveled
Biochem. Mol. Biol. Educ.
47
620-631
2019
Pseudomonas aeruginosa (Q9HVR0), Pseudomonas aeruginosa ATCC 15692 (Q9HVR0), Pseudomonas aeruginosa 1C (Q9HVR0), Pseudomonas aeruginosa PRS 101 (Q9HVR0), Pseudomonas aeruginosa DSM 22644 (Q9HVR0), Pseudomonas aeruginosa CIP 104116 (Q9HVR0), Pseudomonas aeruginosa LMG 12228 (Q9HVR0), Pseudomonas aeruginosa JCM 14847 (Q9HVR0)
Yang, P.; Chen, Y.; Wu, H.; Fang, W.; Liang, Q.; Zheng, Y.; Olsson, S.; Zhang, D.; Zhou, J.; Wang, Z.; Zheng, W.
The 5-oxoprolinase is required for conidiation, sexual reproduction, virulence and deoxynivalenol production of Fusarium graminearum
Curr. Genet.
64
285-301
2018
BRENDA: Fusarium graminearum (I1RLT3), Fusarium graminearum (I1S0H5), Fusarium graminearum, Fusarium graminearum PH-1 (I1RLT3), Fusarium graminearum PH-1 (I1S0H5)
Textmining: Triticum aestivum, Fungi, Saccharomyces cerevisiae, plant
Niehaus, T.D.; Elbadawi-Sidhu, M.; de Crecy-Lagard, V.; Fiehn, O.; Hanson, A.D.
Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight
J. Biol. Chem.
292
16360-16367
2017
BRENDA: Bacillus subtilis (P42963 AND P60495 AND Q7WY77), Bacillus subtilis, Bacillus subtilis 168 (P42963 AND P60495 AND Q7WY77)
Textmining: Bacteria, Escherichia coli, eukaryota
Li, X; Ding, Y; Liu, Y; Ma, Y; Song, J; Wang, Q; Yang, Y
Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies.
Brain Dev
37
952-9
2015
Homo sapiens
Strömme, JH; Solberg, HE
Pyroglutamate hydrolase: kinetic properties of enzyme from rat liver.
Scand J Clin Lab Invest
32
233-7
1973
Rattus
Murao, S; Nishimura, A; Ozaki, Y; Oyama, H; Shin, T
Isolation and characterization of a novel 5-oxoprolinase (without ATP-hydrolyzing) from Alcaligenes faecalis N-38A.
Biosci Biotechnol Biochem
59
2010-2
1995
Alcaligenes faecalis
Nishimura, A; Ozaki, Y; Oyama, H; Shin, T; Murao, S
Purification and characterization of a novel 5-oxoprolinase (without ATP-hydrolyzing activity) from Alcaligenes faecalis N-38A.
Appl Environ Microbiol
65
712-7
1999
Alcaligenes faecalis
Jäger, M; Wolf, S
Localization of 5-oxo-L-prolinase mRNA in the murine choroid plexus by in situ hybridization.
Neurosci Lett
274
171-4
1999
Mus musculus
Nishimura, A; Oyama, H; Hamada, T; Nobuoka, K; Shin, T; Murao, S; Oda, K
Molecular cloning, sequencing, and expression in Escherichia coli of the gene encoding a novel 5-oxoprolinase without ATP-hydrolyzing activity from Alcaligenes faecalis N-38A.
Appl Environ Microbiol
66
3201-5
2000
Alcaligenes faecalis, Escherichia coli
Calpena, E; Casado, M; Martínez-Rubio, D; Nascimento, A; Colomer, J; Gargallo, E; García-Cazorla, A; Palau, F; Artuch, R; Espinós, C
5-Oxoprolinuria in Heterozygous Patients for 5-Oxoprolinase (OPLAH) Missense Changes.
JIMD Rep
7
123-8
2013
Homo sapiens
van der Pol, A; Gil, A; Tromp, J; Silljé, HHW; van Veldhuisen, DJ; Voors, AA; Hoendermis, ES; Grote Beverborg, N; Schouten, EM; de Boer, RA; Bischoff, R; van der Meer, P
OPLAH ablation leads to accumulation of 5-oxoproline, oxidative stress, fibrosis, and elevated fillings pressures: a murine model for heart failure with a preserved ejection fraction.
Cardiovasc Res
114
1871-1882
2018
Mus musculus, Mus sp.
Puente, J; Devoto, MA; Sapag-Hagar, M
Modulation of gamma-glutamyl cycle and glutathione levels in rat mammary gland explants.
Int J Tissue React
8
105-10
1986
Rattus
Mayatepek, E
5-Oxoprolinuria in patients with and without defects in the gamma-glutamyl cycle.
Eur J Pediatr
158
221-5
1999
Homo sapiens
Simon, G; Moog, C; Obert, G
Effects of glutathione precursors on human immunodeficiency virus replication.
Chem Biol Interact
91
217-24
1994
Human immunodeficiency virus 1
Castellón, EA
Glutathione and gamma-glutamyl cycle enzymes in rat testis during sexual maturation.
Arch Androl
33
179-85
0
Rattus
Rose, DM; Hochwald, SN; Harrison, LE; Burt, M
Selective glutathione repletion with oral oxothiazolidine carboxylate (OTZ) in the radiated tumor-bearing rat.
J Surg Res
62
224-8
1996
Metazoa
Gil, A; van der Pol, A; van der Meer, P; Bischoff, R
LC-MS analysis of key components of the glutathione cycle in tissues and body fluids from mice with myocardial infarction.
J Pharm Biomed Anal
160
289-296
2018
Mus sp.
Richman, PG; Meister, A
Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione.
J Biol Chem
250
1422-6
1975
Homo sapiens
Reddy, VN; Chakrapani, B; Rathbun, WB; Hough, MM
Evidence for lens oxoprolinase, an enzyme of the gamma-glutamyl cycle.
Invest Ophthalmol
14
228-32
1975
Oryctolagus cuniculus
Li, LY; Seddon, AP; Meister, A; Inubushi, T
Study of the 5-oxoprolinase reaction by 13C NMR.
J Biol Chem
264
3096-101
1989
Pseudomonas putida, Rattus
Li, LY; Seddon, AP; Meister, A
Interaction of the protein components of 5-oxoprolinase. Substrate-dependent enzyme complex formation.
J Biol Chem
263
6495-501
1988
Pseudomonas putida
Li, LY; Seddon, AP; Meister, A
18O studies on the 5-oxoprolinase reaction. Evidence for a phosphorylated tetrahedral intermediate.
J Biol Chem
262
11020-5
1987
Pseudomonas putida, Rattus
Larsson, A; Mattsson, B; Wauters, EA; van Gool, JD; Duran, M; Wadman, SK
5-oxoprolinuria due to hereditary 5-oxoprolinase deficiency in two brothers--a new inborn error of the gamma-glutamyl cycle.
Acta Paediatr Scand
70
301-8
1981
Homo sapiens
Cohen, LH; Vamos, E; Heinrichs, C; Toppet, M; Courtens, W; Kumps, A; Mardens, Y; Carlsson, B; Grillner, L; Larsson, A
Growth failure, encephalopathy, and endocrine dysfunctions in two siblings, one with 5-oxoprolinase deficiency.
Eur J Pediatr
156
935-8
1997
Homo sapiens
Sass, JO; Gemperle-Britschgi, C; Tarailo-Graovac, M; Patel, N; Walter, M; Jordanova, A; Alfadhel, M; Bari?, I; Çoker, M; Damli-Huber, A; Faqeih, EA; García Segarra, N; Geraghty, MT; Jåtun, BM; Kalkan Uçar, S; Kriewitz, M; Rauchenzauner, M; Bili?, K; Tournev, I; Till, C; Sayson, B; Beumer, D; Ye, CX; Zhang, LH; Vallance, H; Alkuraya, FS; van Karnebeek, CD
Unravelling 5-oxoprolinuria (pyroglutamic aciduria) due to bi-allelic OPLAH mutations: 20 new mutations in 14 families.
Mol Genet Metab
2016
Homo sapiens
Wen, F; Huang, J; Lu, X; Huang, W; Wang, Y; Bai, Y; Ruan, S; Gu, S; Chen, X; Shu, P
Identification and prognostic value of metabolism-related genes in gastric cancer.
Aging (Albany NY)
12
17647-17661
2020
Homo sapiens
Williamson, JM; Boettcher, B; Meister, A
Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis.
Proc Natl Acad Sci U S A
79
6246-9
1982
Mus sp., animal
van der Pol, A; Hoes, MF; de Boer, RA; van der Meer, P
Cardiac foetal reprogramming: a tool to exploit novel treatment targets for the failing heart.
J Intern Med
2020
Mus sp.
May, O; Habenicht, A; Mattes, R; Syldatk, C; Siemann, M
Molecular evolution of hydantoinases.
Biol Chem
379
743-7
1998
Bacteria, Archaea, eukaryota, Paenarthrobacter aurescens, Sander
Yasumoto, K; Suzuki, F
Aspartyl- and glutamyl-lysine crosslinks formation and their nutritional availability.
J Nutr Sci Vitaminol (Tokyo)
36 Suppl 1
S71-7
1990
animal
Wang, T; Chen, X; Schecter, RL; Baruchel, S; Alaoui-Jamali, M; Melnychuk, D; Batist, G
Modulation of glutathione by a cysteine pro-drug enhances in vivo tumor response.
J Pharmacol Exp Ther
276
1169-73
1996
Rattus
Fukagawa, NK; Hercules, E; Ajami, AM
L-2-[(13)C]oxothiazolidine-4-carboxylic acid: a probe for precursor mobilization for glutathione synthesis.
Am J Physiol Endocrinol Metab
278
E171-6
2000
Homo sapiens
Lu, W; Clasquin, MF; Melamud, E; Amador-Noguez, D; Caudy, AA; Rabinowitz, JD
Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer.
Anal Chem
82
3212-21
2010
Saccharomyces cerevisiae
van den Bersselaar, LR; van den Brule, JMD; van der Hoeven, JG
Acetaminophen Use Concomitant with Long-Lasting Flucloxacillin Therapy: A Dangerous Combination.
Eur J Case Rep Intern Med
7
001569
2020
Homo sapiens
Ballester, V; Taylor, WR; Slettedahl, SW; Mahoney, DW; Yab, TC; Sinicrope, FA; Boland, CR; Lidgard, GP; Cruz-Correa, MR; Smyrk, TC; Boardman, LA; Ahlquist, DA; Kisiel, JB
Novel methylated DNA markers accurately discriminate Lynch syndrome associated colorectal neoplasia.
Epigenomics
12
2173-2187
2020
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