Information on EC 3.5.1.B13 - 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase

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The expected taxonomic range for this enzyme is: Escherichia coli

EC NUMBER
COMMENTARY hide
3.5.1.B13
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-deoxy-4-formamido-beta-L-arabinopyranosyl undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose-undecaprenyl phosphate + formate
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol amidohydrolase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-deoxy-4-formamido-beta-L-arabinopyranosyl undecaprenyl phosphate + H2O
4-amino-4-deoxy-alpha-L-arabinose-undecaprenyl phosphate + formate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4-deoxy-4-formamido-beta-L-arabinopyranosyl undecaprenyl phosphate + H2O
4-amino-4-deoxy-alpha-L-arabinose-undecaprenyl phosphate + formate
show the reaction diagram
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because the L-Ara4N unit attached to lipid A is not derivatized with a formyl group, the existence of a deformylase, acting later in the pathway, is postulated. The requirement of the ArnA formyltransferase reaction for the maintenance of polymyxin resistance suggests that an as yet unidentified deformylase must also exist, since neither L-Ara4N-modified lipid A nor the L-Ara4N donor, undecaprenyl phosphate-L-Ara4N, is formylated when isolated from polymyxin resistant cells
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