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anandamide + H2O
arachidonic acid + ethanolamine
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
arachidonyl-7-amino-4-methylcoumarin amide + H2O
arachidonic acid + 7-amino-4-methylcoumarin
fluorogenic substrate
-
-
?
N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide + H2O
4-(pyren-1-yl)butanamide + ethylene glycol
-
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
-
-
-
?
oleamide + H2O
oleic acid + NH3
oleoylethanolamide + H2O
oleic acid + ethanolamine
-
-
-
?
(11Z)-eicosenamide + H2O
(11Z)-eicosenoic acid + NH3
-
105% of the activity with oleamide
-
-
?
(12Z)-octadecenamide + H2O
(12Z)-octadecenoic acid + NH3
-
92% of the activity with oleamide
-
-
?
(13Z)-eicosenamide + H2O
(13Z)-eicosenoic acid + NH3
-
103% of the activity with oleamide
-
-
?
(13Z)-octadecenamide + H2O
(13Z)-octadecenoic acid + NH3
-
82% of the activity with oleamide
-
-
?
(15Z)-octadecenamide + H2O
(15Z)-octadecenoic acid + NH3
-
90% of the activity with oleamide
-
-
?
(5Z)-eicosenamide + H2O
(5Z)-eicosenoic acid + NH3
-
116% of the activity with oleamide
-
-
?
(5Z,8Z,11Z,14Z)-N-(2-fluoroethyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolysis rate is 1.3fold higher than the rate of anandamide hydrolysis
-
-
?
(5Z,8Z,11Z,14Z)-N-(2-hydroxy-1,1-dimethylethyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 4.3% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-(2-methylpropyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 2% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-(3-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolysis rate is 1.5fold higher than the rate of anandamide hydrolysis
-
-
?
(5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 16% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-tert-butylicosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 1.8% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-[(1S)-1-methylpropyl]icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 6.3% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-[(2R)-2-hydroxypropyl]icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolysis rate is 1.2fold higher than the rate of anandamide hydrolysis
-
-
?
(5Z,8Z,11Z,14Z)-N-[(2S)-2-hydroxypropyl]icosa-5,8,11,14-tetraenamide + H2O
?
-
hydrolyzed at 21% the rate of anandamide
-
-
?
(6Z)-octadecenamide + H2O
(6Z)-octadecenoic acid + NH3
-
91% of the activity with oleamide
-
-
?
(7Z)-octadecenamide + H2O
(7Z)-octadecenoic acid + NH3
-
109% of the activity with oleamide
-
-
?
(8Z)-eicosenamide + H2O
(8Z)-eicosenoic acid + NH3
-
112% of the activity with oleamide
-
-
?
(9E)-octadecenamide + H2O
(9E)-octadecenoic acid + NH3
-
52% of the activity with oleamide
-
-
?
(9Z)-N-(2-hydroxyethyl)octadec-9-enamide + H2O
?
-
hydrolyzed at 61% the rate of anandamide
-
-
?
(9Z)-tetradec-9-enamide + H2O
myristoleic acid + NH3
-
86% of the activity with oleamide
-
-
?
(9Z,12Z)-N-(2-hydroxyethyl)octadeca-9,12-dienamide + H2O
?
-
hydrolyzed at 75% the rate of anandamide
-
-
?
(9Z,12Z)-N-[(1R)-2-hydroxy-1-methylethyl]octadeca-9,12-dienamide + H2O
?
-
hydrolyzed at 20.5% the rate of anandamide
-
-
?
(9Z,12Z)-octadeca-9,12-dienamide + H2O
(9Z,12Z)-octadeca-9,12-dienoate + NH3
-
104% of the activity with oleamide
-
-
?
(R)-alpha-methanandamide + H2O
?
-
2.4% of the activity with anandamide
-
-
?
(R)-beta-methanandamide + H2O
?
-
121% of the activity with anandamide
-
-
?
(S)-alpha-methanandamide + H2O
?
-
23% of the activity with anandamide
-
-
?
(S)-beta-methanandamide + H2O
?
-
21% of the activity with anandamide
-
-
?
1-arachidonoylglycerol + H2O
?
-
-
-
-
?
11,14,17-eicosatrienamide + H2O
11,14,17-eicosatrienoic acid + NH3
-
140% of the activity with oleamide
-
-
?
11,14-eicosadienamide + H2O
? + NH3
-
127% of the activity with oleamide
-
-
?
2,2-dimethyloleamide + H2O
2,2-dimethyloleic acid + NH3
-
3% of the activity with oleamide
-
-
?
2-arachidonoylglycerol + H2O
?
-
-
-
-
?
2-methyloleamide + H2O
2-methyloleic acid + NH3
-
7% of the activity with oleamide
-
-
?
2-oleoylglycerol + H2O
?
-
-
-
-
?
8,11,14-eicosatrienamide + H2O
8,11,14-eicosatrienoic acid + NH3
-
138% of the activity with oleamide
-
-
?
alpha-linolenamide + H2O
? + NH3
-
138% of the activity with oleamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
anandamide + H2O
ethanolamine + arachidonic acid
arachidonamide + H2O
arachidonic acid + NH3
arachidonoyl 7-amido-4-methylcoumarin + H2O
arachidonic acid + 7-amino-4-methylcoumarin
-
-
-
-
?
arachidonoyl ethanolamide + H2O
arachidonic acid + ethanolamine
-
-
-
-
?
arachidonoyl p-nitroanilide + H2O
arachidonate + p-nitroaniline
-
-
-
-
?
beta-arachidonoylglycerol + H2O
?
-
hydrolysis is 2.5fold higher than the rate of anandamide hydrolysis
-
-
?
decanoyl 7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
decanoyl p-nitroanilide + H2O
decanoate + p-nitroaniline
-
-
-
-
?
dodecanoamide + H2O
dodecanoic acid + NH3
-
74% of the activity with oleamide
-
-
?
erucamide + H2O
? + NH3
-
83% of the activity with oleamide
-
-
?
heptanoyl p-nitroanilide + H2O
heptanoate + p-nitroaniline
-
-
-
-
?
lauroyl p-nitroanilide + H2O
laurate + p-nitroaniline
-
-
-
-
?
linoelaidamide + H2O
(9E,12E)-octadeca-9,12-dienoic acid + NH3
-
54% of the activity with oleamide
-
-
?
myristic amide + H2O
myristic acid + NH3
myristoyl p-nitroanilide + H2O
myristate + p-nitroaniline
-
-
-
-
?
N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide + H2O
4-pyren-1-ylbutanoic acid + ?
-
-
-
-
?
N-(2-hydroxyethyl)octadecanamide + H2O
?
-
hydrolyzed at 15.0% the rate of anandamide
-
-
?
N-(4-hydroxy-2-methylphenyl) arachidonoyl amide + H2O
4-amino-m-cresol + NH3
-
the rate of metabolism of VDM11 is about 1520% of that for anandamide
-
-
?
N-(o-hydroxyphenyl)arachidonamide + H2O
?
-
-
-
-
?
nervonamide + H2O
? + NH3
-
82% of the activity with oleamide
-
-
?
nonanoyl p-nitroanilide + H2O
nonanoate + p-nitroaniline
-
-
-
-
?
octanoyl p-nitroanilide + H2O
octanoate + p-nitroaniline
-
-
-
-
?
oleamide + H2O
oleic acid + NH3
oleoyl ethanolamide + H2O
oleic acid + ethanolamine
-
-
-
-
?
oleoyl methyl amide + H2O
?
-
-
-
-
?
oleoyl methyl ester + H2O
?
-
-
-
-
?
oleoyl methyl ester + H2O
oleic acid + methanol
-
-
-
-
?
oleoyl p-nitroanilide + H2O
?
-
-
-
-
?
oleoyl p-nitroanilide + H2O
oleate + p-nitroaniline
-
-
-
-
?
palmitic amide + H2O
palmitic acid + NH3
palmitoamide + H2O
palmitic acid + NH3
-
72% of the activity with oleamide
-
-
?
palmitoleamide + H2O
palmitoleic acid + NH3
-
79% of the activity with oleamide
-
-
?
palmitoyl p-nitroanilide + H2O
palmitate + p-nitroaniline
-
-
-
-
?
stearamide + H2O
stearic acid + NH3
-
69% of the activity with oleamide
-
-
?
stearic amide + H2O
stearic acid + NH3
additional information
?
-
anandamide + H2O
arachidonic acid + ethanolamine
-
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
i.e. arachidonoyl ethanolamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
?
oleamide + H2O
oleic acid + NH3
i.e. cis-9-octadecenamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
-
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
-
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
the enzyme is responsible for the hydrolysis of a number of neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing lipid oleamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
168% of the activity with oleamide
-
-
?
arachidonamide + H2O
arachidonic acid + NH3
-
-
-
-
?
arachidonamide + H2O
arachidonic acid + NH3
-
311% of the activity with oleamide
-
-
?
myristic amide + H2O
myristic acid + NH3
-
24.3% of the activity with oleamide
-
-
?
myristic amide + H2O
myristic acid + NH3
-
24% of the activity with anandamide
-
-
?
myristic amide + H2O
myristic acid + NH3
-
83% of the activity with oleamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
-
-
-
?
oleamide + H2O
oleic acid + NH3
-
enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
role of FAAH in epithelial cells of the choroid plexus may be to control the concentration of oleamide in the cerebrospinal fluid. FAAH may exert an important regulatory role in shaping the duration and magnitude of the sleep-inducing effect of endogenously or exogenously derived oleamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
the enzyme is responsible for the hydrolysis of a number of neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing lipid oleamide
-
-
?
oleamide + H2O
oleic acid + NH3
-
the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers
-
-
?
oleamide + H2O
oleic acid + NH3
-
serine residue 241 acts as the catalytic nucleophile of the enzyme. FAAH does not utilize a histidine base for the activation of its serine nucleophile
-
-
?
palmitic amide + H2O
palmitic acid + NH3
-
10% of the activity with anandamide
-
-
?
palmitic amide + H2O
palmitic acid + NH3
-
9.9% of the activity with oleamide
-
-
?
stearic amide + H2O
stearic acid + NH3
-
5.8% of the activity with anandamide
-
-
?
stearic amide + H2O
stearic acid + NH3
-
5.8% of the activity with oleamide
-
-
?
additional information
?
-
-
catalytic efficiency (kcat/Km) of FAAH for nonanoyl p-nitroanilide is approximately 50fold higher than for hexanoyl p-nitroanilide. NAI491 participates in hydrophobic binding interactions with medium-chain FAAH substrates. Use of p-nitroanilide substrates allows for the precise monitoring of enzymatic hydrolysis rates by following the increase in UV absorbance at 382 nm due to the release of p-nitroaniline. p-Nitroanilides are slower FAAH substrates than the corresponding primary amides, however, the binding affinities of these two classes of substrates are equivalent. Due to the slower rates of p-nitroanilide hydrolysis relative to the corresponding primary amides, it can be assumed that pNA substrates are hydrolyzed by FAAH in an acylation rate-limiting manner, allowing for the direct measurement of substrate binding constants through the determination of Km values
-
-
?
additional information
?
-
-
FAAH is an enzyme of broad substrate specificity and is capable of hydrolyzing a wide array of unsaturated, and to a lesser extent saturated, fatty acid primary amides. However, when substituted adjacent to the amide carbonyl, the substrates can be made sterically or electronically resistant to hydrolysis. Long chain saturated fatty acid amides are hydrolyzed slower than the corresponding Z unsaturated fatty acid amides and the rate of hydrolysis increases incrementally with increases in the degree of unsaturation
-
-
?
additional information
?
-
-
hybrid quantum mechanics/molecular mechanics (QM/MM) calculations reveal a new mechanism of nucleophile activation involving a LysSerSer catalytic triad. The proposed mechanism, shows that Lys142 and cis-Ser217 have a direct role in the activation of Ser241, in agreement with kinetic labelling experiments employing the highly reactive fluorophosphonatetetramethyl rhodamine. The greater reduction of Ser241 labelling rate in the K142A/S217A double mutant, compared to the K142A and S217A single mutants, suggests that Lys142 and Ser217 cooperate to deprotonate Ser241
-
-
?
additional information
?
-
-
N,N-bis(2-hydroxyethyl)arachidonamide is not hydrolyzed
-
-
?
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(5-iodo-1,3-oxazol-2-yl)[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
(5-iodo-1,3-oxazol-2-yl)[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
(6E,9E,12E,15E)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one
-
1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
-
1,3-oxazol-2-yl[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]methanone
-
1,3-oxazol-2-yl[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]methanone
-
1,3-oxazol-2-yl[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
1,3-oxazol-2-yl[(3R)-7-phenyl-3,4-dihydro-2H-chromen-3-yl]methanone
-
1,3-oxazol-2-yl[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
1,3-oxazol-2-yl[(3S)-7-phenyl-3,4-dihydro-2H-chromen-3-yl]methanone
-
1-(1H-benzotriazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
-
1-(1H-benzotriazol-1-yl)-3-[(4-phenoxyphenyl)thio]propan-2-one
-
1-(4-benzylpiperazin-1-yl)-2-[4-(2-methylpropyl)phenyl]propan-1-one
18% inhibition at 0.1 mM
1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
the compound belongs to the ketobenzimidazoles, though containing a carbonyl moiety, that do not covalently modify Ser241. These inhibitors achieve potent inhibition of FAAH activity primarily from shape complementarity to the active site and through numerous hydrophobic interactions exhibiting excellent selectivity and good pharmacokinetic properties, nonmechanism-based inhibition. Pharmacokinetic parameters and selectivity 2, overview
1-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(2-methylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
33% inhibition at 0.1 mM
1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(3-methoxyphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
41% inhibition at 0.1 mM
1-[4-(3-methylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(4-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(4-fluorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-(4-methoxyphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
-
1-[4-[(3-chlorophenyl)methyl]piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
8% inhibition at 0.1 mM
2-(2-fluorobiphenyl-4-yl)-N-(2-(3-methylpyridin-2-ylamino)-2-oxoethyl)propanamide
-
2-(2-fluorobiphenyl-4-yl)-N-(3-methylpyridin-2-yl)propanamide
mode of inhibition, overview. Flu-AM1 does not inhibit the enzyme from brain in vivo
2-(4-cyclohexylphenoxy)-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(4-cyclohexylphenoxy)-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(4-cyclohexylphenoxy)-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(4-cyclohexylphenoxy)-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(4-cyclohexylphenoxy)-N-[4-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-(6-methoxynaphthalen-2-yl)-N-(3-methylpyridin-2-yl)propanamide
-
2-(methylamino)-2-oxoethyl [2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl]carbamate
-
2-fluorophenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
2-methyl-N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[4-(2-methylpropyl)phenyl]-1-(4-phenylpiperazin-1-yl)propan-1-one
-
2-[4-(2-methylpropyl)phenyl]-N-(3-methylpyridin-2-yl)propanamide
-
2-[4-(2-methylpropyl)phenyl]-N-[[3-(trifluoromethyl)phenyl]methyl]propanamide
-
2-[4-(2-methylpropyl)phenyl]-N-[[4-(trifluoromethyl)phenyl]methyl]propanamide
-
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
-
3-phenylpropane-1-sulfonyl fluoride
-
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
i.e. ASP8477
4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-(4-benzyloxyphenoxy)butanesulfonyl fluoride
-
4-fluorophenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
4-methoxyphenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
4-phenylbutane-1-sulfonyl fluoride
-
4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[2-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[3-(4-chlorophenoxy)benzyl]-N-(pyridin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,3-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)piperazine-1-carboxamide
-
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[6-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
-
5-(4-benzyloxyphenyl)pentanesulfonyl fluoride
-
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
5-phenylpentane-1-sulfonyl fluoride
-
6-bromo-N-(2-fluorophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxamide
an irreversible covalent inhibitor, binding structure, overview
6-hydroxybiphenyl-3-yl cyclohexylcarbamate
-
6-phenylhexane-1-sulfonyl fluoride
-
7-(2-benzyloxyphenyl)heptanesulfonyl fluoride
-
7-(2-hydroxyphenyl)heptanesulfonyl fluoride
-
7-(3-benzyloxyphenyl)heptanesulfonyl fluoride
-
7-(3-hydroxyphenyl)heptanesulfonyl fluoride
-
7-(4-benzyloxyphenyl)heptane-1-sulfonic acid methyl ester
-
7-(4-benzyloxyphenyl)heptanesulfonyl fluoride
-
7-(4-hydroxyphenyl)heptanesulfonyl fluoride
-
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
7-phenylheptane-1-sulfonyl fluoride
-
8-phenyloctane-1-sulfonyl fluoride
-
biphenyl-3-yl cyclohexylcarbamate
-
hexadecyl sulfonylfluoride
i.e. AM374, is a potent in vitro and in vivo inhibitor of fatty acid amide hydrolase
methyl 6-(2-[[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
methyl 6-(2-[[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
methyl 6-(2-[[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
methyl 6-(2-[[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
methyl arachidonoyl fluorophosphonate
-
N-(1,4-dihydroquinolin-8-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(2-methylphenyl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
-
N-(3-bromopyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3-chloropyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3-iodopyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclobutane-1-carboxamide
-
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclohexane-1-carboxamide
30% inhibition at 0.1 mM
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclopentane-1-carboxamide
-
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclopropane-1-carboxamide
-
N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetamide
-
N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(3-methylpyridin-2-yl)-2-(4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl)propanamide
-
N-(3-methylpyridin-2-yl)-2-(4-[[8-(trifluoromethyl)quinolin-4-yl]amino]phenyl)propanamide
-
N-(4-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(5-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyrazin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyridazin-3-yl)-4-(3-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzylidene)piperidine-1-carboxamide
-
N-(pyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyridin-3-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyridin-4-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-(pyrimidin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide
-
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
-
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
-
N-[(2,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(2,5-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(2,6-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
19% inhibition at 0.1 mM
N-[(2-chlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(2-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(3,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(3-hydroxy-4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
N-[(pyridin-2-yl)methyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[(pyridin-3-yl)methyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea
-
N-[2-[(3-methylpyridin-2-yl)amino]-2-oxoethyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[3-(trifluoromethyl)pyridin-2-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-phenoxyacetamide
-
N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-[4-(propan-2-yl)phenoxy]acetamide
-
N-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
24% inhibition at 0.1 mM
N-[4-(2-methylphenyl)piperazin-1-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
24% inhibition at 0.1 mM
N-[4-(4-chlorophenyl)piperazin-1-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
-
naproxen
38% inhibition at 0.1 mM
OL-135
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
PF-3845
crystal structure analysis of enzyme-inhibitor complex. The inhibitor interacts with the catalytic triad and oxyanion hole residues
phenyl ([4-[(5-phenyl-2H-tetrazol-2-yl)methyl]phenyl]methyl)carbamate
-
phenyl 4-[(1H-indol-1-yl)methyl]piperidine-1-carboxylate
-
phenyl 4-[2-(1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(4-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-chloro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-cyano-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-methoxy-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(5-methyl-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperazine-1-carboxylate
-
phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(7-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[2-(9H-carbazol-9-yl)ethyl]piperidine-1-carboxylate
-
phenyl 4-[3-(1H-indol-1-yl)propyl]piperidine-1-carboxylate
-
phenyl 4-[4-(1H-indol-1-yl)butyl]piperidine-1-carboxylate
-
phenyl [2-[2-(5-phenyl-2H-tetrazol-2-yl)ethoxy]ethyl]carbamate
-
phenyl [4-(1H-indol-1-yl)butyl]carbamate
-
phenyl [5-(1H-indol-1-yl)pentyl]carbamate
-
phenyl [5-(2-phenyl-1H-imidazol-1-yl)pentyl]carbamate
-
phenyl [5-(5-phenyl-2H-tetrazol-2-yl)pentyl]carbamate
-
phenyl [6-(1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(1H-indol-1-yl)hexyl]carbamate
-
phenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(2-phenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(4-phenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(5-benzyl-2H-tetrazol-2-yl)hexyl]carbamate
-
phenyl [6-(5-phenyl-1H-imidazol-1-yl)hexyl]carbamate
-
phenyl [6-(5-phenyl-1H-tetrazol-1-yl)hexyl]carbamate
-
phenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
phenyl [6-[2-(3-chlorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[2-(3-fluorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[2-(3-methoxyphenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[2-(3-methylphenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[2-(4-chlorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
-
phenyl [6-[5-(2-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(3-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(4-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(pyridin-2-yl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(pyridin-3-yl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [6-[5-(pyridin-4-yl)-2H-tetrazol-2-yl]hexyl]carbamate
-
phenyl [7-(1H-indol-1-yl)heptyl]carbamate
-
phenyl [7-(2-phenyl-1H-imidazol-1-yl)heptyl]carbamate
-
phenyl [7-(5-phenyl-2H-tetrazol-2-yl)heptyl]carbamate
-
phenyl [8-(1H-indol-1-yl)octyl]carbamate
-
phenyl [8-(2-phenyl-1H-imidazol-1-yl)octyl]carbamate
-
phenyl [8-(5-phenyl-2H-tetrazol-2-yl)octyl]carbamate
-
pyridin-3-yl 4-(phenylcarbamoyl)piperidine-1-carboxylate
-
pyridin-3-yl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
-
[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3R)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl](1,3-oxazol-2-yl)methanone
-
[(3R)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3R)-7-phenyl-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3S)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl](1,3-oxazol-2-yl)methanone
-
[(3S)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[(3S)-7-phenyl-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(3,5-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3,5-dimethoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
(1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
(2R)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(2S)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
(5E)-5-(4-methoxybenzylidene)-3-[1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indol-5-yl]-1,3-thiazolidine-2,4-dione
-
-
(5Z,8Z,11Z,14Z)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)icosa-5,8,11,14-tetraenamide
-
-
(5Z,8Z,11Z,14Z)-N-[(2R)-tetrahydrofuran-2-ylmethyl]icosa-5,8,11,14-tetraenamide
-
-
(5Z,8Z,11Z,14Z)-N-[(2S)-tetrahydrofuran-2-ylmethyl]icosa-5,8,11,14-tetraenamide
-
-
(6aR,10aR)-3-(1,1-dimethylheptyl)-9-(hydroxymethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
-
-
1,1'-(5,5'-bi-1,3-oxazole-2,2'-diyl)bis(7-phenylheptan-1-one)
-
-
1,3-benzodioxol-5-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
1-(1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(2-oxo-3-[4-[4-(trifluoromethyl)phenoxy]phenoxy]propyl)-1H-indole-5-carboxylic acid
-
21% inhibition at 0.01 mM
1-(2-oxo-3-[[4'-(propan-2-yl)biphenyl-4-yl]oxy]propyl)-1H-indole-5-carboxylic acid
-
-
1-(4-octylphenoxy)-3-[5-(1H-tetrazol-5-yl)-1H-indol-1-yl]propan-2-one
-
-
1-(5-acetyl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-bromo-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-chloro-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-fluoro-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-furan-2-yl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-iodo-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-methyl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
-
-
1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one
-
-
1-[1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indol-5-yl]-1H-benzimidazole-7-carboxylic acid
-
-
1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid
-
-
1-[2-oxo-3-[4-(2-phenoxyethoxy)phenoxy]propyl]-1H-indole-5-carboxylic acid
-
-
1-[2-oxo-3-[4-(2-phenylpropan-2-yl)phenoxy]propyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(4-benzylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indazole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid
-
structure-activity relationship, overview
1-[3-(biphenyl-2-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(biphenyl-3-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(biphenyl-4-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3'-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-methoxybiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-methylbiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
39% inhibition at 0.01 mM
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(4'-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(4'-methoxybiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(4'-methylbiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(4-fluorophenyl)phenoxy]-2-oxopropyl]indazole-5-carboxylic acid
-
-
1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(heptyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(hexyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(nonyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(octyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[5-(2,4-dimethoxypyrimidin-5-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2,6-dimethoxypyrimidin-4-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-benzyl-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
-
1-[5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
-
1-[5-(3-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-aminopyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-fluoropyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-methoxypyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-nitropyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(5-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(6-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(methylsulfanyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(morpholin-4-ylcarbonyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(morpholin-4-ylcarbonyl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
-
1-[5-[(4-methylpiperazin-1-yl)carbonyl]-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
2,2-dimethyl-1,3-dioxolan-4-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carbaldehyde
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carbonitrile
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxylic acid
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylic acid
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carbonitrile
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carboxylic acid
-
-
3'-carbamoyl-biphenyl-3-yl-cyclohexylcarbamate
-
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile
-
-
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide
-
JNJ-1661010
4-(acetylamino)phenyl (4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetate
-
-
4-(acetylamino)phenyl 2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate
-
competitive, also able to inhibit the FAAH activity in rat basophilic leukemia cells as assessed by measuring either the hydrolysis of anandamide, the FAAH-dependent cellular accumulation of anandamide, or the FAAH-dependent recycling of tritium to the cellmembranes
4-(acetylamino)phenyl 2-[[2-(trifluoromethyl)pyridin-4-yl]amino]pyridine-3-carboxylate
-
-
4-(acetylamino)phenyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoate
-
-
4-(acetylamino)phenyl 2-[[3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylate
-
-
4-(acetylamino)phenyl 2-{[2-(trifluoromethyl)pyridin-4-yl]amino}benzoate
-
-
4-(acetylamino)phenyl 3-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate
-
-
4-(acetylamino)phenyl 3-methyl-4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 3-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 4-([[2-(trifluoromethyl)pyridin-4-yl]amino]methyl)benzoate
-
-
4-(acetylamino)phenyl 4-chloro-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 5-chloro-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 5-methyl-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl N-(3-methyl-4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoyl)glycinate
-
-
4-(acetylamino)phenyl N-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoyl)glycinate
-
-
4-(acetylamino)phenyl N-[(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetyl]glycinate
-
-
4-(acetylamino)phenyl N-[2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoyl]glycinate
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile
-
-
4-[3-[4-(decyloxy)phenoxy]-2-oxopropoxy]benzoic acid
-
-
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-morpholin-4-yl-1H-pyrazole-3-carboxamide
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]furan-2-carboxylic acid
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyrimidine-2,4(1H,3H)-dione
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-carboxylic acid
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-sulfonamide
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxamide
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxamide
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylic acid
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyrimidine-2,4(1H,3H)-dione
-
-
7-phenyl-1-(5-phenyl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyrimidin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyrimidin-4-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyrimidin-5-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-thiophen-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-[5-(1H-tetrazol-5-yl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(piperidin-1-ylcarbonyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
-
OL-135, an alpha-keto-heterocycle that is a covalent reversible inhibitor of FAAH
7-phenyl-1-[5-(thiomorpholin-4-ylcarbonyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(trifluoroacetyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[2-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[3-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[4-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[4-(trifluoromethyl)pyridin-2-yl]-1,3-oxazol-2-yl]heptan-1-one
-
-
azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
-
-
ethoxy oleoyl fluorophosphonate
-
irreversible inhibitor, exclusively modifies FAAH at S241
methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-ylphosphonofluoridate
-
-
methyl 2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxylate
-
-
methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate
-
-
methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carboxylate
-
-
methyl 3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate
-
-
methyl 4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate
-
-
methyl 5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]furan-2-carboxylate
-
-
methyl 5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-carboxylate
-
-
methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
-
N,N-dimethyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
-
-
N,N-dimethyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
-
-
N,N-dimethyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
N-(3-methylpyridin-2-yl)-2-(4'-isobutylphenyl)propionamide
-
i.e. Ibu-am5
N-(4-hydroxy-2-methylphenyl) arachidonoyl amide
-
i.e. VDM11, inhibits the metabolism of anandamide by rat brain FAAH. Inhibition may at least in part be a consequence of the compound acting as an alternative substrate
N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
-
i.e. AM404, a bioactive N-acylphenolamine, derived from paracetamol, competitve inhibition
N-(4-hydroxyphenyl)arachidonylamide
-
i.e. AM404, inhibits the metabolism of anandamide by rat brain FAAH
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
-
N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
-
N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
-
-
N-methyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
-
-
N-methyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
-
-
N-methyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
-
-
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
-
a reversible, albeit slowly dissociating inhibitor of FAAH, reversibly and noncovalently inhibiting, molecular docking and computational modeling of interactions of the benzothiazole analogue 1 with humanized rat FAAH by induced fit docking, overview. Failure to observe the formation of covalent enzyme-inhibitor adduct or putative cleavage product using electrospray mass spectrometric techniques
oleoyl ethylamide
-
FAAH inhibitor
oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
oxiran-2-ylmethyl (9Z)-hexadec-9-enoate
-
-
oxiran-2-ylmethyl (9Z)-octadec-9-enoate
-
-
oxiran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
-
-
oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
-
-
oxiran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
-
-
oxiran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
-
-
oxiran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
-
-
oxiran-2-ylmethyl benzoate
-
-
palmitoyl ethanolamide
-
a non-CB1 non-CB2 cannabinoid-like compound
tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z)-hexadec-9-enoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z)-octadec-9-enoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
-
-
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
-
-
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
-
-
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
-
-
tetrahydro-2H-pyran-2-ylmethyl benzoate
-
-
tetrahydro-2H-pyran-4-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
VER-156084
-
a tetrasubstituted azetidine urea FAAH inhibitor
[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
[3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
-
-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
-
-
[3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
-
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
covalent enzyme binding at Ser241 leading to irreversible inhibition, the attack at the carbonyl group by Ser 241 leads to the formation of carbamoylated, catalytically inactive FAAH and releasing the O-biphenyl moiety as the leaving group
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
-
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
i.e. AM3506, irreversible inhibitor for both the rat and the human enzyme
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
-
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
i.e. OL-135, the enzyme inhibitor exhibits antinociceptive and anti-inflammatory activity and increases levels of anandamide in vivo
URB597
-
URB597
a carbamate inhibitor that displays excellent selectivity for FAAH in the nervous system, although the inhibitor does inactivate additional peripheral hydrolases, enzyme-inhibitor binding structure, overview. The inhibitor interacts with the catalytic triad and oxyanion hole residues
URB597
-
-
URB597
-
a carbamate inhibiting FAAH covalently and irreversibly, time-dependent inhibition, overview
additional information
design and synthesis of 2-oxoheterocycle inhibitors of fatty acid amide hydrolase, a 6-phenoxychroman-2-yl-2-ketooxazole series, and a 7-arylchroman-3-yl-2-ketooxazole series. Evaluation and role of conformational constraintsin the acyl side chain, overview
-
additional information
design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors, overview
-
additional information
O-(triazolyl)methyl carbamates as potent fatty acid amide hydrolase inhibitors, overview. These compounds show improved stability in rat plasma and kinetic solubility in buffer with respect to the lead compound O-(1,2,3-triazol-4-yl)methyl carbamate
-
additional information
sulfonyl fluoride inhibitors of fatty acid amide hydrolase, structure-activity relationship, docking and molecular modeling, overview
-
additional information
FAAH inhibition represents a promising strategy to activate the cannabinoid system, since it does not result in the psychotropic and peripheral side effects characterizing the agonists of the cannabinoid receptors
-
additional information
structure-activity relationship studies on a series of aryl N-(omega-imidazolyl- and omega-tetrazolylalkyl)carbamate inhibitors are investigated. A pronounced increase in inhibitory potency is observed if a phenyl residue attached to the carbamate oxygen atom is replaced by a pyridin-3-yl moiety. The most active compounds exhibit IC50 values in the low nanomolar range. Investigations on the metabolic properties of these inhibitors are performed. In rat liver homogenate and in porcine plasma, the extent of their degradation is shown to be strongly dependent on the kind of aryl residue bound to the carbamate as well as on the length and type of the alkyl spacer connecting the carbamate group with the heterocyclic system
-
additional information
-
a series of 5-substituted 7-phenyl-1-(oxazol-2-yl)heptan-1-ones are prepared and evaluated for FAAH inhibitory potency as well as FAAH selectivity versus competitive serine proteases
-
additional information
-
paracetamol itself does not inhibit FAAH, but undergoes a FAAH-dependent two-step metabolic transformation in the brain, liver, and spinal cord to form the bioactive N-acylphenolamine AM404. Synthesis and evaluation of paracetamol ester enzyme inhibitors, structure-activity relationship studies, overview
-
additional information
-
1-(3-biaryloxy-2-oxopropyl)indole-5-carboxylic acids and related compounds can act as dual inhibitors of cytosolic phospholipase A2alpha, EC 3.1.1.4, and fatty acid amide hydrolase, overview. Substituents at the indole 3- and 5-positions and replacement of the indole scaffold of this compound by other heterocycles strongly influences the inhibitory potency against FAAH. No inhibition by 1-[3-(biphenyl-2-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid, N-methyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide, N,N-dimethyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide, 1-[5-(morpholin-4-ylcarbonyl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one, (5E)-5-(4-methoxybenzylidene)-3-[1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indol-5-yl]-1,3-thiazolidine-2,4-dione, 1-[5-(3-benzyl-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one, 1-[5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one, 1-[1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indol-5-yl]-1H-benzimidazole-7-carboxylic acid, and 1-(4-octylphenoxy)-3-[5-(1H-tetrazol-5-yl)-1H-indol-1-yl]propan-2-one at 0.01 mM
-
additional information
-
mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles, long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency, transition-state analogues, overview
-
additional information
-
tetra-substituted azetidine ureas with in vivo activity as fatty acid amide hydrolase inhibitors, overview
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0.025
1,1,1-trifluoro-N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
Rattus norvegicus
37°C, pH 7.4
0.000024
1-(1H-benzotriazol-1-yl)-3-(4-phenoxyphenoxy)propan-2-one
Rattus norvegicus
pH and temperature not specified in the publication
0.0016
1-(1H-benzotriazol-1-yl)-3-[(4-phenoxyphenyl)thio]propan-2-one
Rattus norvegicus
pH and temperature not specified in the publication
0.0001
1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Rattus norvegicus
pH and temperature not specified in the publication
0.0017
1-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.016
1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.0017
1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.016
1-[4-(3-methylphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.0017
1-[4-(4-chlorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.017
1-[4-(4-fluorophenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.0045
1-[4-(4-methoxyphenyl)piperazin-1-yl]-2-[4-(2-methylpropyl)phenyl]propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.017
2-(2-fluorobiphenyl-4-yl)-N-(2-(3-methylpyridin-2-ylamino)-2-oxoethyl)propanamide
Rattus norvegicus
pH 7.4, 37°C
0.00044
2-(2-fluorobiphenyl-4-yl)-N-(3-methylpyridin-2-yl)propanamide
Rattus norvegicus
pH 7.4, 37°C
0.00065
2-(4-cyclohexylphenoxy)-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.047
2-(4-cyclohexylphenoxy)-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.0026
2-(4-cyclohexylphenoxy)-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.0015
2-(4-cyclohexylphenoxy)-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.00035
2-(4-cyclohexylphenoxy)-N-[4-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.00074
2-(6-methoxynaphthalen-2-yl)-N-(3-methylpyridin-2-yl)propanamide
Rattus norvegicus
pH 7.4, 37°C
0.00033
2-fluorophenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.0018
2-methyl-N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.0011
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.013
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.00063
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.00062
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.0047
2-[4-(2-methylpropyl)phenyl]-1-(4-phenylpiperazin-1-yl)propan-1-one
Rattus norvegicus
37°C, pH 7.4
0.0052
2-[4-(2-methylpropyl)phenyl]-N-(3-methylpyridin-2-yl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.028
2-[4-(2-methylpropyl)phenyl]-N-[[3-(trifluoromethyl)phenyl]methyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.051
2-[4-(2-methylpropyl)phenyl]-N-[[4-(trifluoromethyl)phenyl]methyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.0055
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.073
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.017
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.064
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.00006 - 0.000112
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
0.000205
3-phenylpropane-1-sulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.00000442
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
Rattus norvegicus
pH 8.0, 37°C, wild-type enzyme
0.0000033
4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.0000012
4-(4-benzyloxyphenoxy)butanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.00066
4-fluorophenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.0000053 - 0.00065
4-methoxyphenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
0.000088
4-phenylbutane-1-sulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.000012
4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.000034
4-[2-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.0000012
4-[4-(2,3-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.00000046
4-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.0000043 - 0.000074
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
0.00000043
4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.00000017
4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.00000028
4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.00000034
4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.000013
4-[6-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.0000017
4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.0000015
5-(4-benzyloxyphenyl)pentanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000028
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.00005
5-phenylpentane-1-sulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.000036
6-bromo-N-(2-fluorophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
pH and temperature not specified in the publication
0.000038
6-phenylhexane-1-sulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000043
7-(2-benzyloxyphenyl)heptanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000012
7-(2-hydroxyphenyl)heptanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000036
7-(3-benzyloxyphenyl)heptanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000025
7-(3-hydroxyphenyl)heptanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.000269
7-(4-benzyloxyphenyl)heptane-1-sulfonic acid methyl ester
Rattus norvegicus
pH 7.4, 25°C
0.0000037
7-(4-benzyloxyphenyl)heptanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000022
7-(4-hydroxyphenyl)heptanesulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.000037
7-phenylheptane-1-sulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.000176
8-phenyloctane-1-sulfonyl fluoride
Rattus norvegicus
pH 7.4, 25°C
0.0000057
biphenyl-3-yl cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.029
flurbiprofen
Rattus norvegicus
pH 7.4, 37°C
0.0043
N-(1,4-dihydroquinolin-8-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.00074
N-(2-methylphenyl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.0000013
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.00013
N-(3-bromopyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.000058
N-(3-chloropyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.00013
N-(3-iodopyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.0091
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclobutane-1-carboxamide
Rattus norvegicus
37°C, pH 7.4
0.06
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclopentane-1-carboxamide
Rattus norvegicus
37°C, pH 7.4
0.014
N-(3-methylpyridin-2-yl)-1-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)cyclopropane-1-carboxamide
Rattus norvegicus
37°C, pH 7.4
0.048
N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetamide
Rattus norvegicus
37°C, pH 7.4
0.00059
N-(3-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.0031
N-(3-methylpyridin-2-yl)-2-(4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.027
N-(3-methylpyridin-2-yl)-2-(4-[[8-(trifluoromethyl)quinolin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.004
N-(4-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.011
N-(5-methylpyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.002
N-(pyrazin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.012
N-(pyridin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.0064
N-(pyridin-3-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.052
N-(pyridin-4-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.00099
N-(pyrimidin-2-yl)-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.027
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)benzenesulfonamide
Rattus norvegicus
37°C, pH 7.4
0.027
N-([1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]carbamoyl)methanesulfonamide
Rattus norvegicus
37°C, pH 7.4
0.0000012
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.021
N-[(2,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.0044
N-[(2,5-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.0041
N-[(2-chlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.018
N-[(2-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.036
N-[(3,4-dichlorophenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.018
N-[(3-hydroxy-4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.043
N-[(4-methoxyphenyl)methyl]-2-[4-(2-methylpropyl)phenyl]propanamide
Rattus norvegicus
37°C, pH 7.4
0.023
N-[(pyridin-2-yl)methyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.032
N-[(pyridin-3-yl)methyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.021
N-[1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indazol-5-yl]-N'-phenylurea
Rattus norvegicus
37°C, pH 7.4
0.0024 - 0.027
N-[2-[(3-methylpyridin-2-yl)amino]-2-oxoethyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
0.00033
N-[3-(trifluoromethyl)pyridin-2-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.018
N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-phenoxyacetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.0021
N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-[4-(propan-2-yl)phenoxy]acetamide
Rattus norvegicus
assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication
0.017
N-[4-(4-chlorophenyl)piperazin-1-yl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.000025
OL-135
Rattus norvegicus
pH and temperature not specified in the publication
0.00026
phenyl ([4-[(5-phenyl-2H-tetrazol-2-yl)methyl]phenyl]methyl)carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00987
phenyl 4-[(1H-indol-1-yl)methyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00011
phenyl 4-[2-(1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00011
phenyl 4-[2-(4-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00041
phenyl 4-[2-(5-chloro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00097
phenyl 4-[2-(5-cyano-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00013
phenyl 4-[2-(5-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00036
phenyl 4-[2-(5-methoxy-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00074
phenyl 4-[2-(5-methyl-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00081
phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperazine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000046
phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000052
phenyl 4-[2-(7-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00041
phenyl 4-[2-(9H-carbazol-9-yl)ethyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00057
phenyl 4-[3-(1H-indol-1-yl)propyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00018
phenyl 4-[4-(1H-indol-1-yl)butyl]piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0052
phenyl [2-[2-(5-phenyl-2H-tetrazol-2-yl)ethoxy]ethyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00096
phenyl [4-(1H-indol-1-yl)butyl]carbamate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000094
phenyl [5-(1H-indol-1-yl)pentyl]carbamate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00043
phenyl [5-(2-phenyl-1H-imidazol-1-yl)pentyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00049
phenyl [5-(5-phenyl-2H-tetrazol-2-yl)pentyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.006
phenyl [6-(1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00025
phenyl [6-(1H-indol-1-yl)hexyl]carbamate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00047
phenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00029
phenyl [6-(2-phenyl-1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00049
phenyl [6-(4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00088
phenyl [6-(4-phenyl-1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00025
phenyl [6-(5-benzyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00048
phenyl [6-(5-phenyl-1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.0013
phenyl [6-(5-phenyl-1H-tetrazol-1-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00062
phenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000054
phenyl [6-[2-(3-chlorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000112
phenyl [6-[2-(3-fluorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00029
phenyl [6-[2-(3-methoxyphenyl)-1H-imidazol-1-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000075
phenyl [6-[2-(3-methylphenyl)-1H-imidazol-1-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00042
phenyl [6-[2-(4-chlorophenyl)-1H-imidazol-1-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000209
phenyl [6-[5-(2-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00018
phenyl [6-[5-(3-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00057
phenyl [6-[5-(4-chlorophenyl)-2H-tetrazol-2-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00028
phenyl [6-[5-(pyridin-2-yl)-2H-tetrazol-2-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00074
phenyl [6-[5-(pyridin-3-yl)-2H-tetrazol-2-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.0012
phenyl [6-[5-(pyridin-4-yl)-2H-tetrazol-2-yl]hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000093
phenyl [7-(1H-indol-1-yl)heptyl]carbamate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.00024
phenyl [7-(2-phenyl-1H-imidazol-1-yl)heptyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000081
phenyl [7-(5-phenyl-2H-tetrazol-2-yl)heptyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00024
phenyl [8-(1H-indol-1-yl)octyl]carbamate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.0004
phenyl [8-(2-phenyl-1H-imidazol-1-yl)octyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000112
phenyl [8-(5-phenyl-2H-tetrazol-2-yl)octyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00000442
pyridin-3-yl 4-(phenylcarbamoyl)piperidine-1-carboxylate
Rattus norvegicus
37°C, pH 8.0
0.000011
pyridin-3-yl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.000063
URB524
Rattus norvegicus
pH and temperature not specified in the publication
0.000003 - 0.0000046
URB597
0.00007
[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
Rattus norvegicus
pH 9.0, 22°C
0.00005
[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
Rattus norvegicus
pH 9.0, 22°C
0.00009
[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
Rattus norvegicus
pH 9.0, 22°C
0.00046
[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
Rattus norvegicus
pH 9.0, 22°C
0.0000119
[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000062
[1-[(2-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000099
[1-[(2-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000014
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000032
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000076
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000104
[1-[(3,5-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000105
[1-[(3,5-dimethoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000132
[1-[(3-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000121
[1-[(3-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000118
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000098
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000039
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Rattus norvegicus
pH 7.4, 37°C
0.0000058
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
Rattus norvegicus
pH 7.4, 37°C
0.000237
(1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.006
(2R)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.012
(2S)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.00037
(4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.09
(5Z,8Z,11Z,14Z)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)icosa-5,8,11,14-tetraenamide
Rattus norvegicus
-
37°C, substrate: anandamide
0.069
(5Z,8Z,11Z,14Z)-N-[(2R)-tetrahydrofuran-2-ylmethyl]icosa-5,8,11,14-tetraenamide
Rattus norvegicus
-
37°C, substrate: anandamide
0.099
(5Z,8Z,11Z,14Z)-N-[(2S)-tetrahydrofuran-2-ylmethyl]icosa-5,8,11,14-tetraenamide
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.26
(R,S)-ibuprofen
Rattus norvegicus
-
pH 7.4, 37°C
0.091
1,3-benzodioxol-5-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.0051
1-(2-oxo-3-[[4'-(propan-2-yl)biphenyl-4-yl]oxy]propyl)-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000006
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0012
1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0017
1-[2-oxo-3-[4-(2-phenoxyethoxy)phenoxy]propyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0029
1-[2-oxo-3-[4-(2-phenylpropan-2-yl)phenoxy]propyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0019
1-[3-(4-benzylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00016
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indazole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0064
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0023
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0016
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0034
1-[3-(biphenyl-3-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00046
1-[3-(biphenyl-4-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00023
1-[3-[(3'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00025
1-[3-[(3'-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.005
1-[3-[(3-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00059
1-[3-[(3-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0074
1-[3-[(3-methoxybiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000464 - 0.00053
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
0.00024
1-[3-[(4'-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00053
1-[3-[(4'-methoxybiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00058
1-[3-[(4'-methylbiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00009
1-[3-[4-(4-fluorophenyl)phenoxy]-2-oxopropyl]indazole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0026
1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0034
1-[3-[4-(heptyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0035
1-[3-[4-(hexyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0018
1-[3-[4-(nonyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0022
1-[3-[4-(octyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.098
2,2-dimethyl-1,3-dioxolan-4-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.021 - 0.099
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
0.00022
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00531
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0297
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000681
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.14
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00001
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide
Rattus norvegicus
-
JNJ-1661010, without preincubation
0.00018
4-(acetylamino)phenyl (4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetate
Rattus norvegicus
-
pH 7.4, 37°C
0.0001
4-(acetylamino)phenyl 2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate
Rattus norvegicus
-
pH 7.4, 37°C
0.058
4-(acetylamino)phenyl 2-[[2-(trifluoromethyl)pyridin-4-yl]amino]pyridine-3-carboxylate
Rattus norvegicus
-
pH 7.4, 37°C
0.0087
4-(acetylamino)phenyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.3
4-(acetylamino)phenyl 2-[[3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylate
Rattus norvegicus
-
above, pH 7.4, 37°C
0.064
4-(acetylamino)phenyl 2-{[2-(trifluoromethyl)pyridin-4-yl]amino}benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.0015
4-(acetylamino)phenyl 3-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate
Rattus norvegicus
-
pH 7.4, 37°C
0.0046
4-(acetylamino)phenyl 3-methyl-4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.047
4-(acetylamino)phenyl 3-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.022
4-(acetylamino)phenyl 4-([[2-(trifluoromethyl)pyridin-4-yl]amino]methyl)benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.031
4-(acetylamino)phenyl 4-chloro-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.0027
4-(acetylamino)phenyl 4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.0043
4-(acetylamino)phenyl 5-chloro-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.038
4-(acetylamino)phenyl 5-methyl-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
Rattus norvegicus
-
pH 7.4, 37°C
0.003
4-(acetylamino)phenyl N-(3-methyl-4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoyl)glycinate
Rattus norvegicus
-
pH 7.4, 37°C
0.00087
4-(acetylamino)phenyl N-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoyl)glycinate
Rattus norvegicus
-
pH 7.4, 37°C
0.0026
4-(acetylamino)phenyl N-[(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetyl]glycinate
Rattus norvegicus
-
pH 7.4, 37°C
0.00073
4-(acetylamino)phenyl N-[2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoyl]glycinate
Rattus norvegicus
-
pH 7.4, 37°C
0.000053
4-[3-[4-(decyloxy)phenoxy]-2-oxopropoxy]benzoic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000647
azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00263
azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000025
methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-ylphosphonofluoridate
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00541
N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00053
N,N-dimethyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0013
N-(3-methylpyridin-2-yl)-2-(4'-isobutylphenyl)propionamide
Rattus norvegicus
-
pH 7.4, 37°C
0.5
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
Rattus norvegicus
-
above, pH and temperature not specified in the publication
0.242
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.5
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
Rattus norvegicus
-
above, pH and temperature not specified in the publication
0.0115
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000094
N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00453
N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00075
N-methyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.5
N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
Rattus norvegicus
-
above, pH and temperature not specified in the publication
0.000002 - 0.0000051
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
0.012 - 0.019
oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
0.0082 - 0.028
oxiran-2-ylmethyl (9Z)-hexadec-9-enoate
0.011
oxiran-2-ylmethyl (9Z)-octadec-9-enoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.0016 - 0.05
oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
0.061
oxiran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
Rattus norvegicus
-
37°C, substrate: anandamide
0.035
oxiran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
Rattus norvegicus
-
37°C, substrate: anandamide
0.026 - 0.051
tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
0.029
tetrahydro-2H-pyran-2-ylmethyl (9Z)-octadec-9-enoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.0075
tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.019
tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.043
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
Rattus norvegicus
-
37°C, substrate: anandamide
0.018
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
Rattus norvegicus
-
37°C, substrate: anandamide
0.032 - 0.08
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
0.053
tetrahydro-2H-pyran-2-ylmethyl benzoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.028
[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.017
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.5
[3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
above, pH and temperature not specified in the publication
0.0184
[3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000471
[3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000713
[3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000556
[3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00542
[3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000375
[3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00399
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.5
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
Rattus norvegicus
-
above, pH and temperature not specified in the publication
0.000505
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.531
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00524
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.124
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000161
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000854
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000388
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00288
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00458
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000126
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00248
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000447
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00312
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00148
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000937
[3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.5
[3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
above, pH and temperature not specified in the publication
0.042
[3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000413
[3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000715 - 0.00364
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
0.00006
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
Rattus norvegicus
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide
0.000112
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.0000053
4-methoxyphenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.00065
4-methoxyphenyl [6-(5-phenyl-2H-tetrazol-2-yl)hexyl]carbamate
Rattus norvegicus
50 mM Tris-HCl, containing 1 mM sodium EDTA, pH 7.4 at 20°C
0.0000043
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.000074
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
Rattus norvegicus
pH 9.0, 37°C
0.0024
N-[2-[(3-methylpyridin-2-yl)amino]-2-oxoethyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.027
N-[2-[(3-methylpyridin-2-yl)amino]-2-oxoethyl]-2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanamide
Rattus norvegicus
37°C, pH 7.4
0.000003
URB597
Rattus norvegicus
pH and temperature not specified in the publication
0.0000046
URB597
Rattus norvegicus
pH and temperature not specified in the publication
0.000464
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00053
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.021
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.099
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.000002
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
Rattus norvegicus
-
pH 8.0, 22°C, at 78 nM substrate anandamide
0.0000038
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
Rattus norvegicus
-
pH 8.0, 22°C, at 0.01 mM substrate anandamide
0.0000051
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
Rattus norvegicus
-
pH 8.0, 22°C, at 0.005 mM substrate anandamide
0.012
oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.019
oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.0082
oxiran-2-ylmethyl (9Z)-hexadec-9-enoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.028
oxiran-2-ylmethyl (9Z)-hexadec-9-enoate
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.0016
oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.05
oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.026
tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.051
tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
37°C, substrate: anandamide
0.032
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
Rattus norvegicus
-
37°C, substrate: anandamide
0.08
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
Rattus norvegicus
-
37°C, substrate: 2-oleoylglycerol
0.000715
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00364
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
Rattus norvegicus
-
pH and temperature not specified in the publication
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Patricelli, M.P.; Lashuel, H.A.; Giang, D.K.; Kelly, J.W.; Cravatt, B.F.
Comparative characterization of wild type and transmembrane domain-deleted fatty acid amide hydrolase identification of the transmembrane domain as a site for oligomerization
Biochemistry
37
15177-15187
1998
Rattus norvegicus
brenda
Vandevoorde, S.; Fowler, C.J.
Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate
Br. J. Pharmacol.
145
885-893
2005
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Cisneros, J.A.; Vandevoorde, S.; Ortega-Gutierrez, S.; Paris, C.; Fowler, C.J.; Lopez-Rodriguez, M.L.
Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis - comparison with effects upon fatty acid amide hydrolase
J. Med. Chem.
50
5012-5023
2007
Rattus norvegicus
brenda
Wei, B.Q.; Mikkelsen, T.S.; McKinney, M.K.; Lander, E.S.; Cravatt, B.F.
A second fatty acid amide hydrolase with variable distribution among placental mammals
J. Biol. Chem.
281
36569-36578
2006
Homo sapiens (O00519), Homo sapiens (Q6GMR7), Homo sapiens, Mus musculus (O08914), Mus musculus, Rattus norvegicus (P97612)
brenda
Fowler, C.J.; Jonsson, K.O.; Tiger, G.
Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide
Biochem. Pharmacol.
62
517-26
2001
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Patricelli, M.P.; Cravatt, B.F.
Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism
Biochemistry
38
14125-14130
1999
Rattus norvegicus
brenda
Patricelli M.P.; Lovato, M.A.; Cravatt, B.F.
Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties
Biochemistry
38
9804-9812
1999
Rattus norvegicus
brenda
Patricelli, M.P.; Cravatt, B.F.
Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase
Biochemistry
40
6107-6115
2001
Rattus norvegicus
brenda
Boger, D.L.; Fecik, R.A.; Patterson, J.E.; Miyauchi, H.; Patricelli, M.P.; Cravatt, B.F.
Fatty acid amide hydrolase substrate specificity
Bioorg. Med. Chem. Lett.
10
2613-2616
2000
Rattus norvegicus
brenda
Lodola, A.; Mor, M.; Hermann, J.C.; Tarzia, G.; Piomelli, D.; Mulholland, A.J.
QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation
Chem. Commun. (Camb. )
35
4399-401
2005
Rattus norvegicus
brenda
Patricelli, M.P.; Cravatt, B.F.
Clarifying the catalytic roles of conserved residues in the amidase signature family
J. Biol. Chem.
275
19177-19184
2000
Rattus norvegicus
brenda
Lang, W.; Qin, C.; Lin, S.; Khanolkar, A.D.; Goutopoulos, A.; Fan, P.; Abouzid, K.; Meng, Z.; Biegel, D.; Makriyannis, A.
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase
J. Med. Chem.
42
898-902
1999
Rattus norvegicus
brenda
Romero, F.A.; Du, W.; Hwang, I.; Rayl, T.J.; Kimball, F.S.; Leung, D.; Hoover, H.S.; Apodaca, R.L.; Breitenbucher, J.G.; Cravatt, B.F.; Boger, D.L.J.
Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase
J. Med. Chem.
50
1058-68
2007
Rattus norvegicus
brenda
Cravatt, B.F.; Giang, D.K.; Mayfield, S.P.; Boger, D.L.; Lerner, R.A.; Gilula, N.B.
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
Nature
384
83-87
1996
Rattus norvegicus
brenda
Egertova, M.; Cravatt, B.F.; Elphick, M.R.
Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide
Neurosci. Lett.
282
13-16
2000
Rattus norvegicus
brenda
Giang, D.K.; Cravatt, B.F.
Molecular characterization of human and mouse fatty acid amide hydrolases
Proc. Natl. Acad. Sci. USA
94
2238-2242
1997
Rattus norvegicus, Homo sapiens (O00519), Homo sapiens, Mus musculus (O08914), Mus musculus
brenda
Boger, D.L.; Sato, H.; Lerner, A.E.; Hedrick, M.P.; Fecik, R.A.; Miyauchi, H.; Wilkie, G.D.; Austin, B.J.; Patricelli, M.P.; Cravatt, B.F.
Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide
Proc. Natl. Acad. Sci. USA
97
5044-5049
2000
Homo sapiens, Rattus norvegicus
brenda
Bracey, M.H.; Hanson, M.A.; Masuda, K.R.; Stevens, R.C.; Cravatt, B.F.
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling.
Science
298
1793-1796
2002
Rattus norvegicus (P97612)
brenda
Karbarz, M.J.; Luo, L.; Chang, L.; Tham, C.S.; Palmer, J.A.; Wilson, S.J.; Wennerholm, M.L.; Brown, S.M.; Scott, B.P.; Apodaca, R.L.; Keith, J.M.; Wu, J.; Breitenbucher, J.G.; Chaplan, S.R.; Webb, M.
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase
Anesth. Analg.
108
316-329
2009
Rattus norvegicus, Homo sapiens (Q6GMR7), Homo sapiens
brenda
Onnis, V.; Congiu, C.; Bjoerklund, E.; Hempel, F.; Soederstroem, E.; Fowler, C.J.
Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors
J. Med. Chem.
53
2286-2298
2010
Rattus norvegicus
brenda
Lever, I.J.; Robinson, M.; Cibelli, M.; Paule, C.; Santha, P.; Yee, L.; Hunt, S.P.; Cravatt, B.F.; Elphick, M.R.; Nagy, I.; Rice, A.S.
Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury
J. Neurosci.
29
3766-3780
2009
Rattus norvegicus
brenda
Tian, G.; Paschetto, K.A.; Gharahdaghi, F.; Gordon, E.; Wilkins, D.E.; Luo, X.; Scott, C.W.
Mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles: long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency
Biochemistry
50
6867-6878
2011
Homo sapiens, Rattus norvegicus
brenda
Roughley, S.D.; Browne, H.; Macias, A.T.; Benwell, K.; Brooks, T.; D'Alessandro, J.; Daniels, Z.; Dugdale, S.; Francis, G.; Gibbons, B.; Hart, T.; Haymes, T.; Kennett, G.; Lightowler, S.; Matassova, N.; Mansell, H.; Merrett, A.; Misra, A.; Padfield, A.; Parsons, R.; Pratt, R.; Robertson, A.; Simmonite, H.; Tan, K.; Walls, S.B.; Wong, M.
Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity
Bioorg. Med. Chem. Lett.
22
901-906
2012
Homo sapiens, Rattus norvegicus
brenda
Zahov, S.; Drews, A.; Hess, M.; Schulze Elfringhoff, A.; Lehr, M.
1-(3-biaryloxy-2-oxopropyl)indole-5-carboxylic acids and related compounds as dual inhibitors of human cytosolic phospholipase A2alpha and fatty acid amide hydrolase
ChemMedChem
6
544-549
2011
Homo sapiens, Rattus norvegicus
brenda
Strittmatter, F.; Gandaglia, G.; Benigni, F.; Bettiga, A.; Rigatti, P.; Montorsi, F.; Gratzke, C.; Stief, C.; Colciago, G.; Hedlund, P.
Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats
Eur. Urol.
61
98-106
2012
Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Mileni, M.; Kamtekar, S.; Wood, D.C.; Benson, T.E.; Cravatt, B.F.; Stevens, R.C.
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation
J. Mol. Biol.
400
743-754
2010
Rattus norvegicus (P97612)
brenda
Min, X.; Thibault, S.T.; Porter, A.C.; Gustin, D.J.; Carlson, T.J.; Xu, H.; Lindstrom, M.; Xu, G.; Uyeda, C.; Ma, Z.; Li, Y.; Kayser, F.; Walker, N.P.; Wang, Z.
Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)
Proc. Natl. Acad. Sci. USA
108
7379-7384
2011
Homo sapiens (O00519), Rattus norvegicus (P97612)
brenda
Kono, M.; Matsumoto, T.; Imaeda, T.; Kawamura, T.; Fujimoto, S.; Kosugi, Y.; Odani, T.; Shimizu, Y.; Matsui, H.; Shimojo, M.; Kori, M.
Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors
Bioorg. Med. Chem.
22
1468-1478
2014
Homo sapiens (O00519), Rattus norvegicus (P97612), Rattus norvegicus Sprague-Dawley (P97612)
brenda
Duncan, K.K.; Otrubova, K.; Boger, D.L.
alpa-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain
Bioorg. Med. Chem.
22
2763-2770
2014
Rattus norvegicus (P97612)
brenda
Colombano, G.; Albani, C.; Ottonello, G.; Ribeiro, A.; Scarpelli, R.; Tarozzo, G.; Daglian, J.; Jung, K.M.; Piomelli, D.; Bandiera, T.
O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors
ChemMedChem
10
380-395
2015
Homo sapiens (O00519), Homo sapiens, Rattus norvegicus (P97612), Rattus norvegicus SpragueDawley (P97612)
brenda
Cipriano, M.; Bjoerklund, E.; Wilson, A.A.; Congiu, C.; Onnis, V.; Fowler, C.J.
Inhibition of fatty acid amide hydrolase and cyclooxygenase by the N-(3-methylpyridin-2-yl)amide derivatives of flurbiprofen and naproxen
Eur. J. Pharmacol.
720
383-390
2013
Rattus norvegicus (P97612)
brenda
Alapafuja, S.O.; Nikas, S.P.; Bharathan, I.T.; Shukla, V.G.; Nasr, M.L.; Bowman, A.L.; Zvonok, N.; Li, J.; Shi, X.; Engen, J.R.; Makriyannis, A.
Sulfonyl fluoride inhibitors of fatty acid amide hydrolase
J. Med. Chem.
55
10074-10089
2012
Homo sapiens (O00519), Homo sapiens, Rattus norvegicus (P97612)
brenda
Sundermann, T.; Fabian, J.; Hanekamp, W.; Lehr, M.
1-Heteroaryl-3-phenoxypropan-2-ones as inhibitors of cytosolic phospholipase A2alpha and fatty acid amide hydrolase Effect of the replacement of the ether oxygen with sulfur and nitrogen moieties on enzyme inhibition and metabolic stability
Bioorg. Med. Chem.
23
2579-2592
2015
Rattus norvegicus (P97612)
brenda
Terwege, T.; Hanekamp, W.; Garzinsky, D.; Koenig, S.; Koch, O.; Lehr, M.
omega-Imidazolyl- and omega-tetrazolylalkylcarbamates as inhibitors of fatty acid amide hydrolase Biological activity and in vitro metabolic stability
ChemMedChem
11
429-443
2016
Rattus norvegicus (P97612)
brenda
Deplano, A.; Morgillo, C.M.; Demurtas, M.; Bjoerklund, E.; Cipriano, M.; Svensson, M.; Hashemian, S.; Smaldone, G.; Pedone, E.; Luque, F.J.; Cabiddu, M.G.; Novellino, E.; Fowler, C.J.; Catalanotti, B.; Onnis, V.
Novel propanamides as fatty acid amide hydrolase inhibitors
Eur. J. Med. Chem.
136
523-542
2017
Rattus norvegicus (P97612)
brenda
Watabiki, T.; Tsuji, N.; Kiso, T.; Ozawa, T.; Narazaki, F.; Kakimoto, S.
In vitro and in vivo pharmacological characterization of ASP8477 A novel highly selective fatty acid amide hydrolase inhibitor
Eur. J. Pharmacol.
815
42-48
2017
Homo sapiens (B2C6G4), Homo sapiens (O00519), Homo sapiens, Rattus norvegicus (P97612)
brenda
Sunduru, N.; Svensson, M.; Cipriano, M.; Marwaha, S.; Andersson, C.D.; Svensson, R.; Fowler, C.J.; Elofsson, M.
N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors
J. Enzyme Inhib. Med. Chem.
32
513-521
2017
Rattus norvegicus (P97612)
brenda
Deplano, A.; Cipriano, M.; Moraca, F.; Novellino, E.; Catalanotti, B.; Fowler, C.J.; Onnis, V.
Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors
J. Enzyme Inhib. Med. Chem.
34
562-576
2019
Rattus norvegicus (P97612)
brenda
Dahlhaus, H.; Hanekamp, W.; Lehr, M.
(Indolylalkyl)piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH)
MedChemComm
8
616-620
2017
Rattus norvegicus (P97612)
brenda