Disease on EC 3.5.1.92 - pantetheine hydrolase
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Acute Kidney Injury
A Novel Biomarker for Acute Kidney Injury, Vanin-1, for Obstructive Nephropathy: A Prospective Cohort Pilot Study.
Acute Kidney Injury
Urinary vanin-1 as a novel biomarker for early detection of drug-induced acute kidney injury.
Albuminuria
Early urinary biomarkers for renal tubular damage in spontaneously hypertensive rats on a high salt intake.
Albuminuria
Proteomic identification of vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy.
Arthritis, Rheumatoid
A sandwich ELISA for detection of soluble GPI-80, a glycosylphosphatidyl-inositol (GPI)-anchored protein on human leukocytes involved in regulation of neutrophil adherence and migration--its release from activated neutrophils and presence in synovial fluid of rheumatoid arthritis patients.
Asthma
Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response.
Carcinogenesis
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Carcinogenesis
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Carcinoma
Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma.
Carcinoma
GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.
Carcinoma
The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood.
Carcinoma, Renal Cell
GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.
Carcinoma, Renal Cell
The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood.
Cardiovascular Diseases
Diverse biological activities of the vascular non-inflammatory molecules - the Vanin pantetheinases.
Cardiovascular Diseases
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Colitis
Early detection of renal injury using urinary vanin-1 in rats with experimental colitis.
Colitis
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Colitis
Expression of the Vanin Gene Family in Normal and Inflamed Human Skin: Induction by Proinflammatory Cytokines.
Colitis
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity.
Colitis-Associated Neoplasms
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Colitis-Associated Neoplasms
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Colonic Neoplasms
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Colorectal Neoplasms
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Cystinosis
Cysteamine, the molecule used to treat cystinosis, potentiates the antimalarial efficacy of artemisinin.
Cystinosis
Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria.
Dermatitis, Atopic
Expression of the Vanin Gene Family in Normal and Inflamed Human Skin: Induction by Proinflammatory Cytokines.
Diabetes Mellitus, Type 1
Mouse vanin-1 is cytoprotective for islet beta cells and regulates the development of type 1 diabetes.
Diabetes Mellitus, Type 2
Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
Diabetic Nephropathies
Proteomic identification of vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy.
Eczema
Molecular Diagnostics of Psoriasis, Atopic Dermatitis, Allergic Contact Dermatitis and Irritant Contact Dermatitis.
Granuloma
Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection.
HIV Infections
Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case-control study.
Hydronephrosis
Vanin-1 in Renal Pelvic Urine Reflects Kidney Injury in a Rat Model of Hydronephrosis.
Hypertension
Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats.
Hypertension
The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function.
Hypertension
Vanin-1 T26I polymorphism, hypertension and cardiovascular events in two large urban-based prospective studies in Swedes.
Ichthyosis
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Infections
Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium.
Infections
Dissecting Flavivirus Biology in Salivary Gland Cultures from Fed and Unfed Ixodes scapularis (Black-Legged Tick).
Infections
Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria.
Infections
Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.
Infections
Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
Infections
Urinary vanin-1 for predicting acute pyelonephritis in young children with urinary tract infection: a pilot study.
Infections
Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection.
Inflammatory Bowel Diseases
A near-infrared fluorescence probe for imaging of pantetheinase in cells and mice in vivo.
Influenza, Human
Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.
Insulin Resistance
Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
Kidney Diseases
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Leukemia
Expression of GPI-80, a beta2-integrin-associated glycosylphosphatidylinositol-anchored protein, requires neutrophil differentiation with dimethyl sulfoxide in HL-60 cells.
Leukemia, Myeloid, Acute
Vanin 1 (VNN1) levels predict poor outcome in acute myeloid leukemia.
Liver Diseases
Analysis of vanin-1 upregulation and lipid accumulation in hepatocytes in response to a high-fat diet and free fatty acids.
Lupus Erythematosus, Systemic
Vanin-1 as a potential novel biomarker for active nephritis in systemic lupus erythematosus.
Malaria
Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus.
Malaria
Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.
Malaria
Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria.
Malaria
Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
Malaria, Cerebral
Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
Metabolic Diseases
Bioluminescent Probe for Detection of Starvation-Induced Pantetheinase Upregulation.
Metabolic Diseases
MiR-122 targets the vanin 1 gene to regulate its expression in chickens.
Metabolic Diseases
Systemic Nanoparticle-Mediated Delivery of Pantetheinase Vanin-1 Regulates Lipolysis and Adiposity in Abdominal White Adipose Tissue.
Metabolic Diseases
The structure of vanin 1: a key enzyme linking metabolic disease and inflammation.
Neoplasms
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Neoplasms
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Neoplasms
Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients.
Neoplasms
GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.
Neoplasms
In vitro and in vivo biological evaluation of O-carboxymethyl chitosan encapsulated metformin nanoparticles for pancreatic cancer therapy.
Neoplasms
Near-Infrared Fluorescent Probe for Imaging and Evaluating the Role of Vanin-1 in Chemotherapy.
Neoplasms
Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting.
Neoplasms
Pharmacological analysis for mechanisms of GPI-80 release from tumour necrosis factor-alpha-stimulated human neutrophils.
Neoplasms
Vanin-1 inactivation antagonizes the development of adrenocortical neoplasia in Sf-1 transgenic mice.
Neoplasms
Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity.
Nephritis
Vanin-1 as a potential novel biomarker for active nephritis in systemic lupus erythematosus.
Non-alcoholic Fatty Liver Disease
Analysis of vanin-1 upregulation and lipid accumulation in hepatocytes in response to a high-fat diet and free fatty acids.
Obesity
Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
Pancreatic Neoplasms
In vitro and in vivo biological evaluation of O-carboxymethyl chitosan encapsulated metformin nanoparticles for pancreatic cancer therapy.
pantetheine hydrolase deficiency
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
pantetheine hydrolase deficiency
Mouse vanin-1 is cytoprotective for islet beta cells and regulates the development of type 1 diabetes.
pantetheine hydrolase deficiency
Systemic Nanoparticle-Mediated Delivery of Pantetheinase Vanin-1 Regulates Lipolysis and Adiposity in Abdominal White Adipose Tissue.
pantetheine hydrolase deficiency
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity.
pantetheine hydrolase deficiency
Vanin-1 pantetheinase drives smooth muscle cell activation in post-arterial injury neointimal hyperplasia.
Pneumonia
Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.
Psoriasis
Expression of the Vanin Gene Family in Normal and Inflamed Human Skin: Induction by Proinflammatory Cytokines.
Psoriasis
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Psoriasis
Molecular Diagnostics of Psoriasis, Atopic Dermatitis, Allergic Contact Dermatitis and Irritant Contact Dermatitis.
Purpura, Thrombocytopenic, Idiopathic
Value of vanin-1 assessment in adult patients with primary immune thrombocytopenia.
Pyelonephritis
Urinary vanin-1 for predicting acute pyelonephritis in young children with urinary tract infection: a pilot study.
Q Fever
Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection.
Renal Insufficiency, Chronic
Commentary: Urinary vanin-1 and chronic kidney disease in hypertensive patients.
Renal Insufficiency, Chronic
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Renal Insufficiency, Chronic
Urinary vanin-1 associated with chronic kidney disease in hypertensive patients: A pilot study.
Reperfusion Injury
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Sarcoma
Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity.
Sepsis
Plasma Vanin-1 as a Novel Biomarker of Sepsis for Trauma Patients: A Prospective Multicenter Cohort Study.
Shock, Septic
MicroRNA-203 Acts as a Potent Suppressor in Septic Shock by Alleviating Lung Injury via Inhibition of VNN1.
Starvation
Red emission ratio fluorescent probe for the activity of vanin-1 and imaging in vivo.
Thymoma
Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage.
Urinary Tract Infections
Urinary vanin-1 for predicting acute pyelonephritis in young children with urinary tract infection: a pilot study.
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