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Information on EC 3.5.1.9 - arylformamidase and Organism(s) Saccharomyces cerevisiae and UniProt Accession Q04066

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EC Tree
     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.9 arylformamidase
IUBMB Comments
Also acts on other aromatic formylamines.
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This record set is specific for:
Saccharomyces cerevisiae
UNIPROT: Q04066
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Word Map
The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
kynurenine formamidase, afmid, formylase, kfase, formamidase i, formamidase ii, arylformamidase, formylkynurenine formamidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
formyl kynurenine formamidase
-
formamidase I
-
-
-
-
formamidase II
-
-
-
-
formylase
-
-
-
-
formylkynureninase
-
-
-
-
formylkynurenine formamidase
-
-
-
-
kynurine formamidase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxylic acid amide hydrolysis
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
aryl-formylamine amidohydrolase
Also acts on other aromatic formylamines.
CAS REGISTRY NUMBER
COMMENTARY hide
156229-75-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
show the reaction diagram
-
-
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
show the reaction diagram
N-formylanthranilic acid + H2O
formate + anthranilic acid
show the reaction diagram
-
involvement in anthranilate cycle
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
show the reaction diagram
N-formylanthranilic acid + H2O
formate + anthranilic acid
show the reaction diagram
-
involvement in anthranilate cycle
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
dependent
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.18
N-formyl-L-kynurenine
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
161
N-formyl-L-kynurenine
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
56000
-
formamidase I, gel filtration
58500
-
formamidase I, gel filtration
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bode, R.; Birnbaum, D.
Vorkommen und Verteilung multipler Formen der Formamidase bei verschiedenen Hefen
Z. Allg. Mikrobiol.
19
221-222
1979
Saccharomyces cerevisiae, Meyerozyma guilliermondii, Yarrowia lipolytica, Cyberlindnera jadinii, Cyberlindnera fabianii, Ogataea henricii, Rhodotorula sphaerocarpa, Rhodotorula toruloides, Rhodotorula mucilaginosa
Manually annotated by BRENDA team
Moore, G.P.; Sullivan, D.T.
The characterization of multiple forms of kynurenine formidase in Drosophila melanogaster
Biochim. Biophys. Acta
397
468-477
1975
Bos taurus, Saccharomyces cerevisiae, Gallus gallus, Drosophila melanogaster, Drosophila virilis, Mus musculus, Musca domestica, Lithobates pipiens
Manually annotated by BRENDA team
Wogulis, M.; Chew, E.R.; Donohoue, P.D.; Wilson, D.K.
Identification of formyl kynurenine formamidase and kynurenine aminotransferase from Saccharomyces cerevisiae using crystallographic, bioinformatic and biochemical evidence
Biochemistry
47
1608-1621
2008
Saccharomyces cerevisiae (Q04066), Saccharomyces cerevisiae
Manually annotated by BRENDA team