Reference on EC 3.5.1.89 - N-acetylglucosaminylphosphatidylinositol deacetylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Doering, T.L.; Masterson, W.J.; Englund, P.T.; Hart, G.W.
Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine
J. Biol. Chem.
264
11168-11173
1989
Trypanosoma sp.
Milne, K.G.; Field, R.A.; Masterson, W.J.; Cooaz, S.; Brimacombe, J.S.; Ferguson, M.A.J.
Partial purification and characterization of the N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol anchor biosynthesis in African trypanosomes
J. Biol. Chem.
269
16403-16408
1994
Trypanosoma sp.
Sharma, D.K.; Smith, T.K.; Crossman, A.; Brimacombe, J.S.; Ferguson, M.A.J.
Substrate specificity of the N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol membrane anchor biosynthesis in African trypanosomes and human cells
Biochem. J.
328
171-177
1997
Homo sapiens, Trypanosoma brucei
Smith, T.K.; Crossman, A.; Borissow, C.N.; Paterson, M.J.; Dix, A.; Brimacombe, J.S.; Ferguson, M.A.J.
Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors
EMBO J.
20
3322-3332
2001
Homo sapiens, Trypanosoma brucei
Smith, T.K.; Crossman, A.; Paterson, M.J.; Borissow, C.N.; Brimacombe, J.S.; Ferguson, M.A.J.
Specificities of enzymes of glycosylphosphatidylinositol biosynthesis in Trypanosoma brucei and HeLa Cells
J. Biol. Chem.
277
37147-37153
2002
Homo sapiens, Trypanosoma brucei
Pielsticker, L.K.; Mann, K.J.; Lin, W.L.; Sevlever, D.
Raft-like membrane domains contain enzymatic activities involved in the synthesis of mammalian glycosylphosphatidylinositol anchor intermediates
Biochem. Biophys. Res. Commun.
330
163-171
2005
Homo sapiens
Vats, D.; Vishwakarma, R.A.; Bhattacharya, S.; Bhattacharya, A.
Reduction of cell surface glycosylphosphatidylinositol conjugates in Entamoeba histolytica by antisense blocking of E. histolytica GlcNAc-phosphatidylinositol deacetylase expression: effect on cell proliferation, endocytosis, and adhesion to target cells
Infect. Immun.
73
8381-8392
2005
Entamoeba histolytica
Pottekat, A.; Menon, A.K.
Subcellular localization and targeting of N-acetylglucosaminyl phosphatidylinositol de-N-acetylase, the second enzyme in the glycosylphosphatidylinositol biosynthetic pathway
J. Biol. Chem.
279
15743-15751
2004
Homo sapiens (Q9Y2B2), Homo sapiens
Urbaniak, M.D.; Crossman, A.; Chang, T.; Smith, T.K.; van Aalten, D.M.; Ferguson, M.A.
The N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme
J. Biol. Chem.
280
22831-22838
2005
Rattus norvegicus (O35790), Trypanosoma brucei (Q382X3), Trypanosoma brucei
Shams-Eldin, H.; Azzouz, N.; Niehus, S.; Smith, T.K.; Schwarz, R.T.
An efficient method to express GPI-anchor proteins in insect cells
Biochem. Biophys. Res. Commun.
365
657-663
2008
Homo sapiens
Urbaniak, M.D.; Crossman, A.; Ferguson, M.A.
Probing Trypanosoma brucei glycosylphosphatidylinositol biosynthesis using novel precursor-analogues
Chem. Biol. Drug Des.
72
127-132
2008
Trypanosoma brucei
Abdelwahab, N.Z.; Urbaniak, M.D.; Ferguson, M.A.; Crossman, A.T.
Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei
Carbohydr. Res.
346
708-714
2011
Trypanosoma brucei
Abdelwahab, N.Z.; Crossman, A.T.; Sullivan, L.; Ferguson, M.A.; Urbaniak, M.D.
Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness
Chem. Biol. Drug Des.
79
270-278
2012
Trypanosoma brucei
Ashraf, M.; Yadav, B.; Perinthottathil, S.; Kumar, K.S.; Vats, D.; Muthuswami, R.; Komath, S.S.
N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase from Entamoeba histolytica: metal alters catalytic rates but not substrate affinity
J. Biol. Chem.
286
2543-2549
2011
Entamoeba histolytica
Urbaniak, M.D.; Capes, A.S.; Crossman, A.; ONeill, S.; Thompson, S.; Gilbert, I.H.; Ferguson, M.A.
Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase
Carbohydr. Res.
387
54-58
2014
Trypanosoma brucei, Trypanosoma brucei MITat1.4
Ashraf, M.; Sreejith, P.; Yadav, U.; Komath, S.S.
Catalysis by N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase (PIG-L) from Entamoeba histolytica: new roles for conserved residues
J. Biol. Chem.
288
7590-7595
2013
Entamoeba histolytica (C4M0W5), Entamoeba histolytica
Capes, A.S.; Crossman, A.; Urbaniak, M.D.; Gilbert, S.H.; Ferguson, M.A.; Gilbert, I.H.
Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues
Org. Biomol. Chem.
12
1919-1934
2014
Trypanosoma brucei
Almani, P.G.N.; Sharifi, I.; Kazemi, B.; Babaei, Z.; Bandehpour, M.; Salari, S.; Dezaki, E.S.; Tohidi, F.; Mohammadi, M.A.
The role of GlcNAc-PI-de-N-acetylase gene by gene knockout throughhomologous recombination and its consequences on survival, growthand infectivity of Leishmania major in in vitro and in vivo conditions
Acta Trop.
154
63-72
2016
Leishmania major (Q8I8A4), Leishmania major, Leishmania major 75 (Q8I8A4), Leishmania major IR (Q8I8A4), Leishmania major ER (Q8I8A4), Leishmania major MRHO (Q8I8A4)
Rashmi, M.; Swati, D.
In silico drug re-purposing against African sleeping sickness using GlcNAc-PI de-N-acetylase as an experimental target
Comput. Biol. Chem.
59
87-94
2015
Trypanosoma brucei (Q8I8A5), Trypanosoma brucei
Yadav, U.; Rai, K.T.; Sethi, S.C.; Chandraker, A.; Khan, M.A.; Komath, S.S.
Characterising N-acetylglucosaminylphosphatidylinositol de-N-acetylase (CaGpi12), the enzyme that catalyses the second step of GPI biosynthesis in Candida albicans
FEMS Yeast Res.
18
foy067
2018
Candida albicans (A0A1D8PEU2), Candida albicans, Candida albicans ATCC MYA-2876 (A0A1D8PEU2)
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