Information on EC 3.5.1.7 - ureidosuccinase

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The expected taxonomic range for this enzyme is: Clostridium oroticum

EC NUMBER
COMMENTARY hide
3.5.1.7
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RECOMMENDED NAME
GeneOntology No.
ureidosuccinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N-carbamoyl-L-aspartate + H2O = L-aspartate + CO2 + NH3
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Alanine, aspartate and glutamate metabolism
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SYSTEMATIC NAME
IUBMB Comments
N-carbamoyl-L-aspartate amidohydrolase
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CAS REGISTRY NUMBER
COMMENTARY hide
9024-81-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
carbamoylglutamate + H2O
?
show the reaction diagram
-
small amount of activity found
-
-
?
L-carboxymethylhydantoin + H2O
CO2 + ?
show the reaction diagram
-
inert substrate
-
-
?
L-ureidosuccinic acid + H2O
?
show the reaction diagram
-
only the L-isomer is attacked, the D form is completely inactive
-
-
-
L-ureidosuccinic acid + H2O
L-aspartic acid + CO2 + NH3
show the reaction diagram
-
only the L-isomer was attacked, the D form is completely inactive
-
-
?
additional information
?
-
-
L-carboxymethylhydantoin is no substrate
-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-ureidosuccinic acid + H2O
?
show the reaction diagram
-
only the L-isomer is attacked, the D form is completely inactive
-
-
-
additional information
?
-
-
L-carboxymethylhydantoin is no substrate
-
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mn2+
-
absolute requirement
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Sodium thioglycolate
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
glutathione
-
effect less than half that of cysteine
sulfhydryl compound
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
0°C stable for at least 10 days if kept in vacuo, loses activity rapidly when exposed to air either at 0°C or -16°C
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE