Information on EC 3.5.1.63 - 4-acetamidobutyrate deacetylase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.5.1.63
-
RECOMMENDED NAME
GeneOntology No.
4-acetamidobutyrate deacetylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of linear amides
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Arginine and proline metabolism
-
-
Lysine degradation
-
-
Metabolic pathways
-
-
putrescine degradation III
-
-
SYSTEMATIC NAME
IUBMB Comments
4-acetamidobutanoate amidohydrolase
Also acts on N-acetyl-beta-alanine and 5-acetamidopentanoate.
CAS REGISTRY NUMBER
COMMENTARY hide
102347-82-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
CBS 6853
-
-
Manually annotated by BRENDA team
CBS 5839
-
-
Manually annotated by BRENDA team
CBS 5839
-
-
Manually annotated by BRENDA team
CBS 94
-
-
Manually annotated by BRENDA team
CBS 94
-
-
Manually annotated by BRENDA team
CBS 4732
-
-
Manually annotated by BRENDA team
CBS 4732
-
-
Manually annotated by BRENDA team
Trichosporon melibiosaceum
CBS 6087
-
-
Manually annotated by BRENDA team
Trichosporon melibiosaceum CBS 6087
CBS 6087
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-acetamidobutanoate + H2O
acetate + 4-aminobutanoate
show the reaction diagram
5-acetamidopentanoate + H2O
acetate + 5-aminopentanoate
show the reaction diagram
-
-
-
-
?
6-acetamidohexanoate + H2O
acetate + 6-aminohexanoate
show the reaction diagram
-
weak
-
-
?
N-acetyl-beta-alanine + H2O
acetate + beta-alanine
show the reaction diagram
-
-
-
-
?
N-acetyl-DL-Ala + H2O
acetate + DL-Ala
show the reaction diagram
-
weak
-
-
?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
hydroxylammonium
-
1 mM
Sodium mersalyl
-
1 mM
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.29
4-acetamidobutyrate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 11.5
-
-
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
78500
-
x * 78500, SDS-PAGE
122000
-
sucrose density gradient centrifugation
143000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 78500, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE