Reference on EC 3.5.1.23 - ceramidase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hirabayashi, Y.; Kimura, M.; Matsumoto, M.; Yamamoto, K.; Kadowaki, S.; Tochikura, T.
A novel glycosphingolipid hydrolyzing enzyme, glycosphingolipid ceramide deacylase, which cleaves the linkage between the fatty acid and sphingosine base in glycosphingolipids
J. Biochem.
103
1-4
1988
Nocardia sp.
Gatt, S.
Enzymatic hydrolysis of sphingolipids. I. Hydrolysis and synthesis of ceramides by an enzyme from rat brain
J. Biol. Chem.
241
3724-3730
1966
Rattus norvegicus
Bawab, S.E; Bielawska, A.; Hannun, Y.A.
Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain
J. Biol. Chem.
274
27948-27955
1999
Rattus norvegicus
Tani, M.; Okino, N.; Mitsutake, S.; Tanigawa, T.; Izu, H.; Ito, M.
Purification and characterization of a neutral ceramidase from mouse liver
J. Biol. Chem.
275
3462-3468
2000
Mus musculus
Okino, N.; Tani, M.; Imayama, S.; Ito, M.
Purification and characterization of a novel ceramidase from Pseudomonas aeruginoa
J. Biol. Chem.
273
14368-14373
1998
Pseudomonas aeruginosa
Levade, T.; Tempesta, M.C.; Moser, H.W.; Fensom, A.H.; Harzer, K.; Moser, A.B.; Salvayre, R.
Sulfatide and sphingomyelin loading of living cells as tools for the study of ceramide turnover by lysosomal ceramidase - implications for the diagnosis of Farber disease
Biochem. Mol. Med.
54
117-125
1995
Homo sapiens
Bernardo, K.; Hurwitz, R.; Zenk, T.; Desnick, R.J.; Ferlinz, K.; Schuchman, E.H.; Sandhoff, K.
Purification, characterization, and biosynthesis of human acid ceramidase
J. Biol. Chem.
270
11098-11102
1995
Homo sapiens
Yada, Y.; Higuchi, K.; Imokawa, G.
Purifiction and biochemical characterization of membrane-bound epidermal ceramides from guinea pig skin
J. Biol. Chem.
270
12677-12684
1995
Cavia porcellus
Linke, T.; Lansmann, S.; Sandhoff, K.
Purification of acid ceramidase from human pacenta
Methods Enzymol.
311
201-207
1999
Homo sapiens
Romiti, E.; Vasta, V.; Meacci, E.; Farnararo, M.; Linke, T.; Ferlinz, K.; Sandhoff, K.; Bruni, P.
Characterization of sphingomyelinase activity released by thrombin-stimulated platelets
Mol. Cell. Biochem.
205
75-81
2000
Homo sapiens
Usta, J.; El Bawab, S.; Roddy, P.; Szulc, Z.M.; Yusuf; Hannun, A.; Bielawska, A.
Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase
Biochemistry
40
9657-9668
2001
Rattus norvegicus
El Bawab, S.; Birbes, H.; Roddy, P.; Szulc, Z.M.; Bielawska, A.; Hannun, Y.A.
Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase
J. Biol. Chem.
276
16758-16766
2001
Rattus norvegicus
Mitsutake, S.; Tani, M.; Okino, N.; Mori, K.; Ichinose, S.; Omori, A.; Iida, H.; Nakamura, T.; Ito, M.
Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney
J. Biol. Chem.
276
26249-26259
2001
Rattus norvegicus (Q91XT9)
Mao, C.; Xu, R.; Szulc, Z.M.; Bielawski, J.; Becker, K.P.; Bielawska, A.; Galadari, S.H.; Hu, W.; Obeid, L.M.
Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase. An enzyme that preferentially regulates metabolism of very long chain ceramides
J. Biol. Chem.
278
31184-31191
2003
Mus musculus (Q8R4X1), Mus musculus
He, X.; Okino, N.; Dhami, R.; Dagan, A.; Gatt, S.; Schulze, H.; Sandhoff, K.; Schuchman, E.H.
Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase
J. Biol. Chem.
278
32978-32986
2003
Homo sapiens
Tani, M.; Okino, N.; Sueyoshi, N.; Ito, M.
Conserved amino acid residues in the COOH-terminal tail are indispensable for the correct folding and localization and enzyme activity of neutral ceramidase
J. Biol. Chem.
279
29351-29358
2004
Pseudomonas aeruginosa, Rattus norvegicus
Nieuwenhuizen, W.F.; van Leeuwen, S.; Jack, R.W.; Egmond, M.R.; Gotz, F.
Molecular cloning and characterization of the alkaline ceramidase from Pseudomonas aeruginosa PA01
Protein Expr. Purif.
30
94-104
2003
Pseudomonas aeruginosa (Q9I596)
Kita, K.; Okino, N.; Ito, M.
Reverse hydrolysis reaction of a recombinant alkaline ceramidase of Pseudomonas aeruginosa
Biochim. Biophys. Acta
1485
111-120
2000
Pseudomonas aeruginosa
Nieuwenhuizen, W.F.; van Leeuwen, S.; Gotz, F.; Egmond, M.R.
Synthesis of a novel fluorescent ceramide analogue and its use in the characterization of recombinant ceramidase from Pseudomonas aeruginosa PA01
Chem. Phys. Lipids
114
181-191
2002
Pseudomonas aeruginosa
Jensen, J.M.; Forl, M.; Winoto-Morbach, S.; Seite, S.; Schunck, M.; Proksch, E.; Schutze, S.
Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging
Exp. Dermatol.
14
609-618
2005
Mus musculus
Olsson, M.; Duan, R.D.; Ohlsson, L.; Nilsson, A.
Rat intestinal ceramidase: purification, properties, and physiological relevance
Am. J. Physiol. Gastrointest. Liver Physiol.
287
G929-G937
2004
Rattus norvegicus
Hwang, Y.H.; Tani, M.; Nakagawa, T.; Okino, N.; Ito, M.
Subcellular localization of human neutral ceramidase expressed in HEK293 cells
Biochem. Biophys. Res. Commun.
331
37-42
2005
Homo sapiens (Q9NR71), Homo sapiens
Galadari, S.; Wu, B.X.; Mao, C.; Roddy, P.; El Bawab, S.; Hannun, Y.A.
Identification of a novel amidase motif in neutral ceramidase
Biochem. J.
393
687-695
2006
no activity in Saccharomyces cerevisiae, Rattus norvegicus (Q91XT9), Homo sapiens (Q9NR71), Homo sapiens
Xu, R.; Jin, J.; Hu, W.; Sun, W.; Bielawski, J.; Szulc, Z.; Taha, T.; Obeid, L.M.; Mao, C.
Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P
FASEB J.
20
1813-1825
2006
Homo sapiens (Q5QJU3), Homo sapiens
Elojeimy, S.; Holman, D.H.; Liu, X.; El-Zawahry, A.; Villani, M.; Cheng, J.C.; Mahdy, A.; Zeidan, Y.; Bielwaska, A.; Hannun, Y.A.; Norris, J.S.
New insights on the use of desipramine as an inhibitor for acid ceramidase
FEBS Lett.
580
4751-4756
2006
Homo sapiens
Yoshimura, Y.; Tani, M.; Okino, N.; Iida, H.; Ito, M.
Molecular cloning and functional analysis of zebrafish neutral ceramidase
J. Biol. Chem.
279
44012-44022
2004
Danio rerio
Chavez, J.A.; Holland, W.L.; Baer, J.; Sandhoff, K.; Summers, S.A.
Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling
J. Biol. Chem.
280
20148-20153
2005
Homo sapiens
Tani, M.; Igarashi, Y.; Ito, M.
Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu
J. Biol. Chem.
280
36592-36600
2005
Mus musculus
Zeidan, Y.H.; Pettus, B.J.; Elojeimy, S.; Taha, T.; Obeid, L.M.; Kawamori, T.; Norris, J.S.; Hannun, Y.A.
Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production
J. Biol. Chem.
281
24695-24703
2006
Mus musculus
Kono, M.; Dreier, J.L.; Ellis, J.M.; Allende, M.L.; Kalkofen, D.N.; Sanders, K.M.; Bielawski, J.; Bielawska, A.; Hannun, Y.A.; Proia, R.L.
Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids
J. Biol. Chem.
281
7324-7331
2006
Mus musculus
Monick, M.M.; Mallampalli, R.K.; Bradford, M.; McCoy, D.; Gross, T.J.; Flaherty, D.M.; Powers, L.S.; Cameron, K.; Kelly, S.; Merrill, A.H.; Hunninghake, G.W.
Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity
J. Immunol.
173
123-135
2004
Homo sapiens
Houben, E.; Holleran, W.M.; Yaginuma, T.; Mao, C.; Obeid, L.M.; Rogiers, V.; Takagi, Y.; Elias, P.M.; Uchida, Y.
Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis
J. Lipid Res.
47
1063-1070
2006
Homo sapiens (Q5QJU3)
Duan, R.D.; Verkade, H.J.; Cheng, Y.; Havinga, R.; Nilsson, A.
Effects of bile diversion in rats on intestinal sphingomyelinases and ceramidase
Biochim. Biophys. Acta
1771
196-201
2007
Rattus norvegicus
Duan, R.
Sphingomyelinase and ceramidase in the intestinal tract
Eur. J. Lipid Sci. Technol.
109
987-993
2007
Homo sapiens
-
Okino, N.; Ito, M.
Ceramidase enhances phospholipase C-induced hemolysis by Pseudomonas aeruginosa
J. Biol. Chem.
282
6021-6030
2007
Pseudomonas aeruginosa, Pseudomonas aeruginosa AN17
Park, J.; Schuchman, E.H.
Acid ceramidase and human disease
Biochim. Biophys. Acta
1758
2133-2138
2006
Homo sapiens
Ohlsson, L.; Palmberg, C.; Duan, R.D.; Olsson, M.; Bergman, T.; Nilsson, A.
Purification and characterization of human intestinal neutral ceramidase
Biochimie
89
950-960
2007
Homo sapiens
Saad, A.F.; Meacham, W.D.; Bai, A.; Anelli, V.; Elojeimy, S.; Mahdy, A.E.; Turner, L.S.; Cheng, J.; Bielawska, A.; Bielawski, J.; Keane, T.E.; Obeid, L.M.; Hannun, Y.A.; Norris, J.S.; Liu, X.
The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy
Cancer Biol. Ther.
6
1455-1460
2007
Homo sapiens
Eliyahu, E.; Park, J.H.; Shtraizent, N.; He, X.; Schuchman, E.H.
Acid ceramidase is a novel factor required for early embryo survival
FASEB J.
21
1403-1409
2007
Mus musculus
Kim, H.L.; Satta, Y.
Population genetic analysis of the N-acylsphingosine amidohydrolase gene associated with mental activity in humans
Genetics
178
1505-1515
2008
Homo sapiens
Shtraizent, N.; Eliyahu, E.; Park, J.H.; He, X.; Shalgi, R.; Schuchman, E.H.
Autoproteolytic cleavage and activation of human acid ceramidase
J. Biol. Chem.
283
11253-11259
2008
Homo sapiens
Sun, W.; Xu, R.; Hu, W.; Jin, J.; Crellin, H.A.; Bielawski, J.; Szulc, Z.M.; Thiers, B.H.; Obeid, L.M.; Mao, C.
Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes
J. Invest. Dermatol.
128
389-397
2008
Homo sapiens (Q13510), Homo sapiens (Q8TDN7), Homo sapiens
Wu, B.X.; Snook, C.F.; Tani, M.; Buellesbach, E.E.; Hannun, Y.A.
Large-scale purification and characterization of recombinant Pseudomonas ceramidase: regulation by calcium
J. Lipid Res.
48
600-608
2007
Pseudomonas sp.
Cho, K.W.
Bioluminescent assay for sphingolipid ceramide N-deacylase using Vibrio harveyi dark mutant M-17
J. Microbiol.
46
585-589
2008
Pseudomonas sp.
Ohlsson, L.; Hjelte, L.; Huehn, M.; Scholte, B.J.; Wilke, M.; Flodstroem-Tullberg, M.; Nilsson, A.
Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice
J. Pediatr. Gastroenterol. Nutr.
47
547-554
2008
Mus musculus
Zhu, Q.; Jin, J.F.; Shan, X.H.; Liu, C.P.; Mao, X.D.; Xu, K.F.; Liu, C.
Chronic activation of neutral ceramidase protects beta-cells against cytokine-induced apoptosis
Acta Pharmacol. Sin.
29
593-599
2008
Rattus norvegicus (Q91XT9)
Mao, C.; Obeid, L.M.
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
Biochim. Biophys. Acta
1781
424-434
2008
Homo sapiens, Homo sapiens (Q5QJU3), Homo sapiens (Q8TDN7), Homo sapiens (Q9NR71), Homo sapiens (Q9NUN7), Mus musculus (Q8R4X1), Mus musculus (Q8VD53), Mus musculus (Q9D099), Mus musculus (Q9JHE3), Mus musculus (Q9WV54), Mus musculus
Lucki, N.; Sewer, M.B.
The cAMP-responsive element binding protein (CREB) regulates the expression of acid ceramidase (ASAH1) in H295R human adrenocortical cells
Biochim. Biophys. Acta
1791
706-713
2009
Homo sapiens
Wu, B.X.; Zeidan, Y.H.; Hannun, Y.A.
Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation
Biochim. Biophys. Acta
1791
730-739
2009
Mus musculus
Shimizu, M.; Tada, E.; Makiyama, T.; Yasufuku, K.; Moriyama, Y.; Fujino, H.; Nakamura, H.; Murayama, T.
Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytosolic phospholipase A2alpha; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signaling
Cell. Signal.
21
440-447
2009
Cricetulus griseus
Sun, W.; Hu, W.; Xu, R.; Jin, J.; Szulc, Z.M.; Zhang, G.; Galadari, S.H.; Obeid, L.M.; Mao, C.
Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion
FASEB J.
23
656-666
2009
Homo sapiens
Inoue, T.; Okino, N.; Kakuta, Y.; Hijikata, A.; Okano, H.; Goda, H.M.; Tani, M.; Sueyoshi, N.; Kambayashi, K.; Matsumura, H.; Kai, Y.; Ito, M.
Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase
J. Biol. Chem.
284
9566-9577
2009
Rattus norvegicus (Q91XT9), Pseudomonas aeruginosa (Q9I596), Pseudomonas aeruginosa
Mahdy, A.E.; Cheng, J.C.; Li, J.; Elojeimy, S.; Meacham, W.D.; Turner, L.S.; Bai, A.; Gault, C.R.; McPherson, A.S.; Garcia, N.; Beckham, T.H.; Saad, A.; Bielawska, A.; Bielawski, J.; Hannun, Y.A.; Keane, T.E.; Taha, M.I.; Hammouda, H.M.; Norris, J.S.; Liu, X.
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer
Mol. Ther.
17
430-438
2009
Homo sapiens
Acharya, J.K.; Dasgupta, U.; Rawat, S.S.; Yuan, C.; Sanxaridis, P.D.; Yonamine, I.; Karim, P.; Nagashima, K.; Brodsky, M.H.; Tsunoda, S.; Acharya, U.
Cell-nonautonomous function of ceramidase in photoreceptor homeostasis
Neuron
57
69-79
2008
Drosophila melanogaster (Q9VA70)
Pata, M.O.; Wu, B.X.; Bielawski, J.; Xiong, T.C.; Hannun, Y.A.; Ng, C.K.
Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice
Plant J.
55
1000-1009
2008
Oryza sativa
Houben, E.; Hachem, J.P.; De Paepe, K.; Rogiers, V.
Epidermal ceramidase activity regulates epidermal desquamation via stratum corneum acidification
Skin Pharmacol. Physiol.
21
111-118
2008
Mus musculus
Okino, N.; Ikeda, R.; Ito, M.
Expression, purification, and characterization of a recombinant neutral ceramidase from Mycobacterium tuberculosis
Biosci. Biotechnol. Biochem.
74
316-321
2010
Mycobacterium tuberculosis
Yang, Q.; Gong, Z.J.; Zhou, Y.; Yuan, J.Q.; Cheng, J.; Tian, L.; Li, S.; Lin, X.D.; Xu, R.; Zhu, Z.R.; Mao, C.
Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity
Cell. Mol. Life Sci.
67
1477-1490
2010
Drosophila melanogaster (Q9VIP7), Drosophila melanogaster, Drosophila melanogaster BL-18012 (Q9VIP7)
Claus, R.A.; Dorer, M.J.; Bunck, A.C.; Deigner, H.P.
Inhibition of sphingomyelin hydrolysis: targeting the lipid mediator ceramide as a key regulator of cellular fate
Curr. Med. Chem.
16
1978-2000
2009
Homo sapiens
Liu, X.; Cheng, J.C.; Turner, L.S.; Elojeimy, S.; Beckham, T.H.; Bielawska, A.; Keane, T.E.; Hannun, Y.A.; Norris, J.S.
Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy
Expert Opin. Ther. Targets
13
1449-1458
2009
Homo sapiens
Eliyahu, E.; Shtraizent, N.; Martinuzzi, K.; Barritt, J.; He, X.; Wei, H.; Chaubal, S.; Copperman, A.B.; Schuchman, E.H.
Acid ceramidase improves the quality of oocytes and embryos and the outcome of in vitro fertilization
FASEB J.
24
1229-1238
2010
Homo sapiens
Xu, R.; Sun, W.; Jin, J.; Obeid, L.M.; Mao, C.
Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes
FASEB J.
24
2507-2515
2010
Homo sapiens, Mus musculus
Tada, S.; Matsushita-Morita, M.; Suzuki, S.; Kusumoto, K.; Kashiwagi, Y.
Characterization of a neutral ceramidase orthologue from Aspergillus oryzae
FEMS Microbiol. Lett.
298
157-165
2009
Aspergillus oryzae RIB40 (Q2UN98)
Abrahan, C.E.; Miranda, G.E.; Agnolazza, D.L.; Politi, L.E.; Rotstein, N.P.
Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors
Invest. Ophthalmol. Vis. Sci.
51
1171-1180
2010
Rattus norvegicus
Mao, Z.; Sun, W.; Xu, R.; Novgorodov, S.; Szulc, Z.M.; Bielawski, J.; Obeid, L.M.; Mao, C.
Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of 4-HPR in tumor cells
J. Biol. Chem.
285
29087-29090
2010
Homo sapiens
Hu, W.; Xu, R.; Sun, W.; Szulc, Z.M.; Bielawski, J.; Obeid, L.M.; Mao, C.
Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis
J. Biol. Chem.
285
7964-7976
2010
Homo sapiens
Sun, W.; Jin, J.; Xu, R.; Hu, W.; Szulc, Z.M.; Bielawski, J.; Obeid, L.M.; Mao, C.
Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)
J. Biol. Chem.
285
8995-9007
2010
Homo sapiens
Novgorodov, S.A.; Wu, B.X.; Gudz, T.I.; Bielawski, J.; Ovchinnikova, T.V.; Hannun, Y.A.; Obeid, L.M.
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA
J. Biol. Chem.
286
25352-25362
2011
Mus musculus, Rattus norvegicus
ONeill, S.M.; Houck, K.L.; Yun, J.K.; Fox, T.E.; Kester, M.
AP-1 binding transcriptionally regulates human neutral ceramidase
Arch. Biochem. Biophys.
511
31-39
2011
Homo sapiens
Thayyullathil, F.; Chathoth, S.; Hago, A.; Patel, M.; Szulc, Z.M.; Hannun, Y.; Galadari, S.
Purification and characterization of a second type of neutral ceramidase from rat brain: a second more hydrophobic form of rat brain ceramidase
Biochim. Biophys. Acta
1811
242-252
2011
Rattus norvegicus
Zhou, Y.; Lin, X.W.; Yang, Q.; Zhang, Y.R.; Yuan, J.Q.; Lin, X.D.; Xu, R.; Cheng, J.; Mao, C.; Zhu, Z.R.
Molecular cloning and characterization of neutral ceramidase homologue from the red flour beetle, Tribolium castaneum
Biochimie
93
1124-1131
2011
Tribolium castaneum
Canals, D.; Perry, D.M.; Jenkins, R.W.; Hannun, Y.A.
Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases
Br. J. Pharmacol.
163
694-712
2011
Homo sapiens, Homo sapiens (Q13510), Homo sapiens (Q8TDN7), Homo sapiens (Q9NR71)
Park, J.; Yoon, S.
Ceramide, a crucial functional lipid, and its metabolic regulation by acid ceramidase
Food Sci. Biotechnol.
19
859-864
2010
Homo sapiens, Mus musculus
-
Beckham, T.H.; Lu, P.; Cheng, J.C.; Zhao, D.; Turner, L.S.; Zhang, X.; Hoffman, S.; Armeson, K.E.; Liu, A.; Marrison, T.; Hannun, Y.A.; Liu, X.
Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B
Int. J. Cancer
131
2034-2043
2012
Homo sapiens
Jenkins, R.W.; Clarke, C.J.; Canals, D.; Snider, A.J.; Gault, C.R.; Heffernan-Stroud, L.; Wu, B.X.; Simbari, F.; Roddy, P.; Kitatani, K.; Obeid, L.M.; Hannun, Y.A.
Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase
J. Biol. Chem.
286
13292-13303
2011
Homo sapiens
Yuan, C.; Rao, R.P.; Jesmin, N.; Bamba, T.; Nagashima, K.; Pascual, A.; Preat, T.; Fukusaki, E.; Acharya, U.; Acharya, J.K.
CDase is a pan-ceramidase in Drosophila
Mol. Biol. Cell
22
33-43
2011
Drosophila melanogaster
Draper, J.M.; Xia, Z.; Smith, R.A.; Zhuang, Y.; Wang, W.; Smith, C.D.
Discovery and evaluation of inhibitors of human ceramidase
Mol. Cancer Ther.
10
2052-2061
2011
Homo sapiens
Lucki, N.C.; Bandyopadhyay, S.; Wang, E.; Merrill, A.H.; Sewer, M.B.
Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression
Mol. Endocrinol.
26
228-243
2012
Homo sapiens, Homo sapiens (Q13510)
Pizzirani, D.; Bach, A.; Realini, N.; Armirotti, A.; Mengatto, L.; Bauer, I.; Girotto, S.; Pagliuca, C.; De Vivo, M.; Summa, M.; Ribeiro, A.; Piomelli, D.
Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase
Angew. Chem. Int. Ed. Engl.
54
485-489
2015
Homo sapiens (Q13510), Mus musculus (Q9WV54)
Ramachandra, N.; Conzelmann, A.
Membrane topology of yeast alkaline ceramidase YPC1
Biochem. J.
452
585-594
2013
Saccharomyces cerevisiae (P38298), Saccharomyces cerevisiae (Q02896), Saccharomyces cerevisiae
Morad, S.; Levin, J.; Tan, S.; Fox, T.; Feith, D.; Cabot, M.
Novel off-target effect of tamoxifen - inhibition of acid ceramidase activity in cancer cells
Biochim. Biophys. Acta
1831
1657-1664
2013
Homo sapiens (Q13510)
Ito, M.; Okino, N.; Tani, M.
New insight into the structure, reaction mechanism, and biological functions of neutral ceramidase
Biochim. Biophys. Acta
1841
682-691
2014
Dictyostelium discoideum, Mycobacterium tuberculosis, Oryza sativa, Pseudomonas aeruginosa, Tribolium castaneum, Dermatophilus congolensis, Triticum aestivum (A9YFM2), Aspergillus oryzae (Q5B5D5), Danio rerio (Q5W7F1), Rattus norvegicus (Q91XT9), Mus musculus (Q9JHE3), Homo sapiens (Q9NR71), Drosophila melanogaster (Q9VA70), Laodelphax striatellus (R4N4U2)
Bhabak, K.; Proksch, D.; Redmer, S.; Arenz, C.
Novel fluorescent ceramide derivatives for probing ceramidase substrate specificity
Bioorg. Med. Chem.
20
6154-6161
2012
Homo sapiens (Q13510), Homo sapiens (Q9NR71)
Bhabak, K.; Arenz, C.
Novel amide- and sulfonamide-based aromatic ethanolamines: Effects of various substituents on the inhibition of acid and neutral ceramidases
Bioorg. Med. Chem.
20
6162-6170
2012
Homo sapiens (Q13510), Homo sapiens (Q9NR71)
Bhabak, K.P.; Kleuser, B.; Huwiler, A.; Arenz, C.
Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues
Bioorg. Med. Chem.
21
874-882
2013
Homo sapiens (Q13510), Homo sapiens (Q9NR71)
Bhabak, K.P.; Hauser, A.; Redmer, S.; Banhart, S.; Heuer, D.; Arenz, C.
Development of a novel FRET probe for the real-time determination of ceramidase activity
ChemBioChem
14
1049-1052
2013
Homo sapiens (Q9NR71), Mus musculus (Q9WV54)
Zhou, Y.; Lin, X.W.; Zhang, Y.R.; Huang, Y.J.; Zhang, C.H.; Yang, Q.; Li, H.Y.; Yuan, J.Q.; Cheng, J.A.; Xu, R.; Mao, C.; Zhu, Z.R.
Identification and biochemical characterization of Laodelphax striatellus neutral ceramidase
Insect Mol. Biol.
22
366-375
2013
Laodelphax striatellus (R4N4U2), Laodelphax striatellus
Chathoth, S.; Thayyullathil, F.; Galadari, A.; Patel, M.; Galadari, S.
Purification and biochemical characterization of membrane-bound neutral ceramidase from camel brain (Camelus dromedarius)
Int. J. Biochem. Mol. Biol.
4
54-66
2013
Camelus dromedarius
Cheng, J.; Bai, A.; Beckham, T.; Tucker Marrison, S.; Yount, C.; Young, K.; Lu, P.; Bartlett, A.; Wu, B.; Keane, B.; Armeson, K.; Marshall, D.; Keane, T.; Smith, M.; Ellen Jones, E.; Drake Jr., R.; Bielawska, A.; Norris, J.; Liu, X.
Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse
J. Clin. Invest.
123
4344-4358
2013
Homo sapiens (Q13510), Homo sapiens
Camacho, L.; Meca-Cortes, O.; Abad, J.L.; Garcia, S.; Rubio, N.; Diaz, A.; Celia-Terrassa, T.; Cingolani, F.; Bermudo, R.; Fernandez, P.L.; Blanco, J.; Delgado, A.; Casas, J.; Fabrias, G.; Thomson, T.M.
Acid ceramidase as a therapeutic target in metastatic prostate cancer
J. Lipid Res.
54
1207-1220
2013
Homo sapiens (Q13510)
Pizzirani, D.; Pagliuca, C.; Realini, N.; Branduardi, D.; Bottegoni, G.; Mor, M.; Bertozzi, F.; Scarpelli, R.; Piomelli, D.; Bandiera, T.
Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR)
J. Med. Chem.
56
3518-3530
2013
Rattus norvegicus (Q6P7S1)
Lucki, N.C.; Li, D.; Bandyopadhyay, S.; Wang, E.; Merrill, A.H.; Sewer, M.B.
Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor
Mol. Cell. Biol.
32
4419-4431
2012
Homo sapiens (Q13510), Homo sapiens
Alves, M.; Trionnaire, E.; Ribeiro, I.; Carpentier, S.; Harzer, K.; Levade, T.; Ribeiro, M.
Molecular basis of acid ceramidase deficiency in a neonatal form of Farber disease: identification of the first large deletion in ASAH1 gene
Mol. Genet. Metab.
109
276-281
2013
Homo sapiens (Q13510), Homo sapiens
Chen, L.Y.; Shi, D.Q.; Zhang, W.J.; Tang, Z.S.; Liu, J.; Yang, W.C.
The Arabidopsis alkaline ceramidase TOD1 is a key turgor pressure regulator in plant cells
Nat. Commun.
6
6030
2015
Arabidopsis thaliana (Q6DBD7), Arabidopsis thaliana Landsberg erecta (Q6DBD7)
Wu, J.X.; Li, J.; Liu, Z.; Yin, J.; Chang, Z.Y.; Rong, C.; Wu, J.L.; Bi, F.C.; Yao, N.
The Arabidopsis ceramidase AtACER functions in disease resistance and salt tolerance
Plant J.
81
767-780
2015
Arabidopsis thaliana (Q94IB9)
Beckham, T.H.; Cheng, J.C.; Lu, P.; Marrison, S.T.; Norris, J.S.; Liu, X.
Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling
PLoS ONE
8
e76593
2013
Homo sapiens (Q13510), Homo sapiens
Oizumi, A.; Nakayama, H.; Okino, N.; Iwahara, C.; Kina, K.; Matsumoto, R.; Ogawa, H.; Takamori, K.; Ito, M.; Suga, Y.; Iwabuchi, K.
Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate
PLoS ONE
9
e89402
2014
Pseudomonas aeruginosa
Realini, N.; Solorzano, C.; Pagliuca, C.; Pizzirani, D.; Armirotti, A.; Luciani, R.; Costi, M.P.; Bandiera, T.; Piomelli, D.
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity
Sci. Rep.
3
1035
2013
Homo sapiens (Q13510), Homo sapiens, Rattus norvegicus (Q6P7S1)
Coant, N.; Hannun, Y.A.
Neutral ceramidase advances in mechanisms, cell regulation, and roles in cancer
Adv. Biol. Regul.
71
141-146
2019
Nilaparvata lugens, Amorphophallus muelleri (A0A2D1WBF2), Rattus norvegicus (Q91XT9), Mus musculus (Q9JHE3), Homo sapiens (Q9NR71)
Azuma, M.M.; Balani, P.; Boisvert, H.; Gil, M.; Egashira, K.; Yamaguchi, T.; Hasturk, H.; Duncan, M.; Kawai, T.; Movila, A.
Endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis-induced inflammation in vitro
Biochem. Biophys. Res. Commun.
495
2383-2389
2018
Homo sapiens (Q13510), Homo sapiens
Bai, A.; Bielawska, A.; Rahmaniyan, M.; Kraveka, J.M.; Bielawski, J.; Hannun, Y.A.
Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites
Bioorg. Med. Chem.
26
6067-6075
2018
Homo sapiens (Q13510)
Baduva, K.; Buechter, L.; Kreyenkamp, K.; Westphal, L.; Wilker, B.; Kohnen, M.; Schuchman, E.H.; Edwards, M.J.; Becker, K.A.; Gulbins, E.; Carpinteiro, A.
Signalling effects induced by acid ceramidase in human epithelial or leukemic cell lines
Cell. Physiol. Biochem.
52
1092-1102
2019
Homo sapiens (Q13510), Homo sapiens
Li, Y.; Chen, Q.; Yang, L.; Li, Y.; Zhang, Y.; Qiu, Y.; Ren, J.; Lu, C.
Identification of highly potent N-acylethanolamine acid amidase (NAAA) inhibitors optimization of the terminal phenyl moiety of oxazolidone derivatives
Eur. J. Med. Chem.
139
214-221
2017
Rattus norvegicus (Q6P7S1)
Ferraz, M.J.; Marques, A.R.; Appelman, M.D.; Verhoek, M.; Strijland, A.; Mirzaian, M.; Scheij, S.; Ouairy, C.M.; Lahav, D.; Wisse, P.; Overkleeft, H.S.; Boot, R.G.; Aerts, J.M.
Lysosomal glycosphingolipid catabolism by acid ceramidase formation of glycosphingoid bases during deficiency of glycosidases
FEBS Lett.
590
716-725
2016
Homo sapiens (Q13510), Homo sapiens, Mus musculus (Q9WV54)
Li, J.; Bi, F.C.; Yin, J.; Wu, J.X.; Rong, C.; Wu, J.L.; Yao, N.
An Arabidopsis neutral ceramidase mutant ncer1 accumulates hydroxyceramides and is sensitive to oxidative stress
Front. Plant Sci.
6
460
2015
Arabidopsis thaliana (F4HQM3), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (F4HQM3)
Rajput, V.B.; Karthikeyan, M.; Ramasamy, S.
Zebrafish acid ceramidase expression in Pichia pastoris GS115 and biochemical characterization
Int. J. Biol. Macromol.
122
587-593
2019
Danio rerio (Q6PH71), Danio rerio
Ordonez, Y.F.; Abad, J.L.; Aseeri, M.; Casas, J.; Garcia, V.; Casasampere, M.; Schuchman, E.H.; Levade, T.; Delgado, A.; Triola, G.; Fabrias, G.
Activity-based imaging of acid ceramidase in living cells
J. Am. Chem. Soc.
141
7736-7742
2019
Homo sapiens (Q13510)
Zhang, C.H.; Zhang, M.J.; Shi, X.X.; Mao, C.; Zhu, Z.R.
Alkaline ceramidase mediates the oxidative stress response in Drosophila melanogaster through sphingosine
J. Insect Sci.
19
13
2019
Drosophila melanogaster (M9PDG7), Drosophila melanogaster
Sakamoto, W.; Coant, N.; Canals, D.; Obeid, L.M.; Hannun, Y.A.
Functions of neutral ceramidase in the Golgi apparatus
J. Lipid Res.
59
2116-2125
2018
Homo sapiens (Q9NR71)
Tan, S.F.; Dunton, W.; Liu, X.; Fox, T.E.; Morad, S.A.F.; Desai, D.; Doi, K.; Conaway, M.R.; Amin, S.; Claxton, D.F.; Wang, H.G.; Kester, M.; Cabot, M.C.; Feith, D.J.; Loughran, T.P.
Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-kappaB-dependent P-glycoprotein upregulation
J. Lipid Res.
60
1078-1086
2019
Homo sapiens (Q13510), Homo sapiens
Gebai, A.; Gorelik, A.; Li, Z.; Illes, K.; Nagar, B.
Structural basis for the activation of acid ceramidase
Nat. Commun.
9
1621
2018
Homo sapiens (Q9NUN7)
Vasiliauskaite-Brooks, I.; Healey, R.D.; Rochaix, P.; Saint-Paul, J.; Sounier, R.; Grison, C.; Waltrich-Augusto, T.; Fortier, M.; Hoh, F.; Saied, E.M.; Arenz, C.; Basu, S.; Leyrat, C.; Granier, S.
Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy
Nat. Commun.
9
5437
2018
Homo sapiens (Q9NUN7), Homo sapiens
Vasiliauskaite-Brooks, I.; Sounier, R.; Rochaix, P.; Bellot, G.; Fortier, M.; Hoh, F.; De Colibus, L.; Bechara, C.; Saied, E.M.; Arenz, C.; Leyrat, C.; Granier, S.
Structural insights into adiponectin receptors suggest ceramidase activity
Nature
544
120-123
2017
Homo sapiens (Q86V24)
Leclerc, J.; Garandeau, D.; Pandiani, C.; Gaudel, C.; Bille, K.; Nottet, N.; Garcia, V.; Colosetti, P.; Pagnotta, S.; Bahadoran, P.; Tondeur, G.; Mograbi, B.; Dalle, S.; Caramel, J.; Levade, T.; Ballotti, R.; Andrieu-Abadie, N.; Bertolotto, C.
Lysosomal acid ceramidase ASAH1 controls the transition between invasive and proliferative phenotype in melanoma cells
Oncogene
38
1282-1295
2019
Homo sapiens (Q13510), Homo sapiens
Doan, N.B.; Nguyen, H.S.; Al-Gizawiy, M.M.; Mueller, W.M.; Sabbadini, R.A.; Rand, S.D.; Connelly, J.M.; Chitambar, C.R.; Schmainda, K.M.; Mirza, S.P.
Acid ceramidase confers radioresistance to glioblastoma cells
Oncol. Rep.
38
1932-1940
2017
Homo sapiens (Q13510)
Shi, X.X.; Huang, Y.J.; Begum, M.A.; Zhu, M.F.; Li, F.Q.; Zhang, M.J.; Zhou, W.W.; Mao, C.; Zhu, Z.R.
A neutral ceramidase, NlnCDase, is involved in the stress responses of brown planthopper, Nilaparvata lugens (Stal)
Sci. Rep.
8
1130
2018
Nilaparvata lugens
Malinina, L.; Brown, R.E.
Catalytic mechanism of eukaryotic neutral ceramidase
Structure
23
1371-1372
2015
Homo sapiens (Q9NR71), Homo sapiens
html completed
