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Disease on EC 3.5.1.23 - ceramidase

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DISEASE
TITLE OF PUBLICATION
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Acquired Immunodeficiency Syndrome
Ceramidase expression facilitates membrane turnover and endocytosis of rhodopsin in photoreceptors.
Current status and perspectives in ceramide-targeting molecular medicine.
Adenocarcinoma
Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and ?1 integrin/FAK-mediated signalling.
Adiponectin and adiponectin receptor in relation to colorectal cancer progression.
Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma.
Globular adiponectin inhibits leptin-stimulated esophageal adenocarcinoma cell proliferation via adiponectin receptor 2-mediated suppression of UHRF1.
Adenocarcinoma of Lung
Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinase-mediated pathway.
Sphingosine-1-Phosphate Contributes to TLR9-Induced TNF-? Release in Lung Tumor Cells.
Adenoma
Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and ?1 integrin/FAK-mediated signalling.
Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas.
Expression of adiponectin receptors 1 and 2 and the leptin receptor in human adrenal tumors.
Expression of adiponectin receptors in mouse adrenal glands and the adrenocortical Y-1 cell line: Adiponectin regulates steroidogenesis.
Adenomatous Polyps
Adiponectin suppresses tumorigenesis in Apc(Min)(/+) mice.
Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer.
Adrenal Cortex Neoplasms
Expression of adiponectin receptors 1 and 2 and the leptin receptor in human adrenal tumors.
Albuminuria
Deletion of the gene for adiponectin accelerates diabetic nephropathy in the Ins2 (+/C96Y) mouse.
Alopecia
Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells.
Alzheimer Disease
Altered Brain Adiponectin Receptor Expression in the 5XFAD Mouse Model of Alzheimer's Disease.
Current status and perspectives in ceramide-targeting molecular medicine.
Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain.
Small molecule of adiponectin receptor agonist-AdipoRon-for Alzheimer disease: abridged secondary publication.
[Effect of moxibustion at "Shenque" (CV8) and "Zusanli" (ST36) on expression of adiponectin and adiponectin receptor in Alzheimer's disease rats].
Arthritis
Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.
Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis.
Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency.
Arthritis, Experimental
Blockade of adiponectin receptor 1 signaling inhibits synovial inflammation and alleviates joint damage in collagen-induced arthritis.
Arthritis, Juvenile
Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.
Arthritis, Rheumatoid
Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappaB pathway.
Adiponectin receptor 1 mediates the difference in adiponectin- induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts.
Association of adiponectin and adiponectin receptor gene polymorphisms with rheumatoid arthritis in a Chinese population.
High Adiponectin and Adiponectin Receptor 1 Expression in Synovial Fluids and Synovial Tissues of Patients with Rheumatoid Arthritis.
Peripheral osteolysis in adults linked to ASAH1 (acid ceramidase) mutations: A new presentation of Farber disease.
Asthma
Adiponectin in Asthma: Implications for Phenotyping.
Atherosclerosis
Adipocyte Hypoxia-Inducible Factor 2? Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism.
Adiponectin receptor 2 deficiency results in reduced atherosclerosis in the brachiocephalic artery in apolipoprotein E deficient mice.
Adiponectin Regulation and Function.
Association between adiponectin receptor 2 gene polymorphisms and cerebral infarction.
Current status and perspectives in ceramide-targeting molecular medicine.
Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes.
miR-449a induces EndMT, promotes the development of atherosclerosis by targeting the interaction between AdipoR2 and E-cadherin in Lipid Rafts.
Reduced adiponectin receptor signalling accelerates atherosclerosis and may worsen the outcome in type 2 diabetes mellitus - another one of those missing links?
The effects of oleanolic acid on atherosclerosis in different animal models.
Bacterial Infections
Current status and perspectives in ceramide-targeting molecular medicine.
Bone Diseases, Metabolic
Pathophysiological mechanism of bone loss in type 2 diabetes involves inverse regulation of osteoblast function by PPAR? coactivator-1? and skeletal muscle atrogenes: adiponectin receptor 1 as a potential target for reversing diabetes-induced osteopenia.
Brain Contusion
Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
Brain Injuries
Designer Adiponectin Receptor Agonist Stabilizes Metabolic Function and Prevents Brain Injury Caused by HIV Protease Inhibitors.
Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
Brain Injuries, Traumatic
Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
Brain Ischemia
Electroacupuncture Attenuates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice Through Adiponectin Receptor 1-Mediated Phosphorylation of GSK-3?
Brain Neoplasms
Acid ceramidase is a novel drug target for pediatric brain tumors.
Breast Neoplasms
Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.
Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.
Adipokines expression and epithelial cell polarity in normal and cancerous breast tissue.
Adiponectin and adiponectin receptor 1 expression proteins levels are modified in breast cancer in postmenopausal women with obesity.
Adiponectin receptor signaling on dendritic cells blunts antitumor immunity.
ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis.
Anticancer effect of acid ceramidase inhibitor ceranib-2 in human breast cancer cell lines MCF-7, MDA MB-231 by the activation of SAPK/JNK, p38 MAPK apoptotic pathways, inhibition of the Akt pathway, downregulation of ER?.
C6-Ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth.
Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor.
Correction to: Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor.
Demonstration of adiponectin receptors 1 and 2 mRNA expression in human breast cancer cells.
Development of second generation peptides modulating cellular adiponectin receptor responses.
Effects of Two Types of Calorie Restriction on Methylation Levels of Adiponectin Receptor 1 (AdipoR1) and Leptin Receptor Overlapping Transcript (Leprot) in a MMTV-TGF-? Breast Cancer Mouse Model.
Examining impacts of ceranib-2 on the proliferation, morphology and ultrastructure of human breast cancer cells.
Expression of AdipoR1 and AdipoR2 Receptors as Leptin-Breast Cancer Regulation Mechanisms.
Expression of leptin, leptin receptor, adiponectin, and adiponectin receptor in ductal carcinoma in situ and invasive breast cancer.
Gene expression of adipokines and adipokine receptors in the tumor microenvironment: associations of lower expression with more aggressive breast tumor features.
Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression.
Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer.
Growth-inhibitory effect of adiponectin via adiponectin receptor 1 on human breast cancer cells through inhibition of S-phase entry without inducing apoptosis.
Histotype-specific analysis of acid ceramidase expression in ovarian cancer.
Immunohistochemical analysis of adipokine and adipokine receptor expression in the breast tumor microenvironment: associations of lower leptin receptor expression with estrogen receptor-negative status and triple-negative subtype.
Influence of insulin resistance on adiponectin receptor expression in breast cancer.
Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies.
Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies.
miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer.
No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk.
Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Silencing lnc-ASAH2B-2 Inhibits Breast Cancer Cell Growth via the mTOR Pathway.
Targeting ceramide metabolic pathway induces apoptosis in human breast cancer cell lines.
The value of detection of S100A8 and ASAH1 in predicting the chemotherapy response for breast cancer patients.
Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk.
Bronchiolitis
Expression of adiponectin receptor 1 is indicative of favorable prognosis in non-small cell lung carcinoma.
Carcinogenesis
Acid ceramidase as a therapeutic target in metastatic prostate cancer.
Adiponectin Receptor Expression Predicts Favorable Prognosis in Cases of Hepatocellular Carcinoma.
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.
Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment.
Ceramidases, roles in sphingolipid metabolism and in health and disease.
Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis.
Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression.
Human acid ceramidase is overexpressed but not mutated in prostate cancer.
LncRNA KCNQ1OT1 inhibits the radiosensitivity and promotes the tumorigenesis of hepatocellular carcinoma via the miR-146a-5p/ACER3 axis.
Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
Tamoxifen is a candidate first-in-class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells-Unrecognized players in tumorigenesis.
Carcinoma
Adiponectin receptor expression in gastric carcinoma: implications in tumor development and progression.
Adiponectin receptor expression in human malignant tissues.
Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors.
Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies.
Expression of adiponectin receptor 1 is indicative of favorable prognosis in non-small cell lung carcinoma.
Expression of adiponectin receptors 1 and 2 and the leptin receptor in human adrenal tumors.
microRNA-423-3p promotes tumor progression via modulation of AdipoR2 in laryngeal carcinoma.
Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
Carcinoma, Ductal
Expression of leptin, leptin receptor, adiponectin, and adiponectin receptor in ductal carcinoma in situ and invasive breast cancer.
The value of detection of S100A8 and ASAH1 in predicting the chemotherapy response for breast cancer patients.
Carcinoma, Endometrioid
Expression levels of adiponectin receptors are decreased in human endometrial adenocarcinoma tissues.
Carcinoma, Hepatocellular
Adiponectin Receptor Expression Predicts Favorable Prognosis in Cases of Hepatocellular Carcinoma.
Adiponectin receptor R1 is upregulated by valproic acid but not by topiramate in human hepatoma cell line, HepG2.
Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling.
An adiponectin receptor, T-cadherin, was selectively expressed in intratumoral capillary endothelial cells in hepatocellular carcinoma: possible cross talk between T-cadherin and FGF-2 pathways.
Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis.
Human alkaline ceramidase 2 promotes the growth, invasion, and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid-like 3B.
Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo.
Carcinoma, Intraductal, Noninfiltrating
Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.
Expression of leptin, leptin receptor, adiponectin, and adiponectin receptor in ductal carcinoma in situ and invasive breast cancer.
Carcinoma, Non-Small-Cell Lung
Expression of adiponectin receptor 1 is indicative of favorable prognosis in non-small cell lung carcinoma.
Carcinoma, Ovarian Epithelial
Acid Ceramidase (AC)-A Key Enzyme of Sphingolipid Metabolism-Correlates With Better Prognosis in Epithelial Ovarian Cancer.
Adiponectin Reverses the Proliferative Effects of Estradiol and IGF-1 in Human Epithelial Ovarian Cancer Cells by Downregulating the Expression of Their Receptors.
Carcinoma, Renal Cell
Adiponectin receptor expression in human malignant tissues.
Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate.
Carcinoma, Squamous Cell
Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
Cardiomegaly
AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload.
Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway.
Cardiomyopathies
HILIC-MS-based metabolomics reveal that Astragalus polysaccharide alleviates doxorubicin-induced cardiomyopathy by regulating sphingolipid and glycerophospholipid homeostasis.
Cardiomyopathy, Hypertrophic
Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by rapamycin.
Cardiovascular Diseases
A polymorphism in the gene encoding AdipoR1 affects olfactory recognition.
AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload.
Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study.
In silico analysis of nonsynonymous single nucleotide polymorphisms of the human adiponectin receptor 2 (ADIPOR2) gene.
Intra-abdominal fat adiponectin receptors expression and cardiovascular metabolic risk factors in obesity and diabetes.
[Research progress in regulation of adiponectin receptors expression].
Carotid Artery Diseases
Intensive Statin Therapy Compromises the Adiponectin-AdipoR Pathway in the Human Monocyte-Macrophage Lineage.
ceramidase deficiency
ACER3 supports development of acute myeloid leukemia.
Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy.
Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.
Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities.
Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.
Acid ceramidase deficiency: Farber disease and SMA-PME.
Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content.
Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.
Adiponectin receptor 2 deficiency results in reduced atherosclerosis in the brachiocephalic artery in apolipoprotein E deficient mice.
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.
Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.
ASAH1 pathogenic variants associated with acid ceramidase deficiency: Farber disease and spinal muscular atrophy with progressive myoclonic epilepsy.
ASAH1-related disorders: Description of 15 novel pediatric patients and expansion of the clinical phenotype.
Bone marrow transplantation for infantile ceramidase deficiency (Farber disease).
Ceramidase deficiency in Farber's disease (lipogranulomatosis).
Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency.
Clinical diagnosis of a new case of ceramidase deficiency (Farber's disease).
Clinical features and genetics in non-5q spinal muscular atrophy caused by acid ceramidase deficiency.
Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.
Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency.
Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo.
Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner.
Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids.
Farber disease: an ultrastructural study. Report of a case and review of the literature.
Farber disease: clinical presentation, pathogenesis and a new approach to treatment.
Farber's disease in two siblings, sural nerve and subcutaneous biopsies by light and electron microscopy.
Farber's lipogranulomatosis: ceramidase deficiency and prolonged survival in three relatives.
Gene-Based Association Testing of Dichotomous Traits With Generalized Functional Linear Mixed Models Using Extended Pedigrees: Applications to Age-Related Macular Degeneration.
Hematopoietic stem cell transplant does not prevent neurological deterioration in infants with Farber disease: Case report and literature review.
Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency.
Involvement of caspase-3 and GD3 ganglioside in ceramide-induced apoptosis in Farber disease.
Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice.
Model SV40-transformed fibroblast lines for metabolic studies of human prosaposin and acid ceramidase deficiencies.
Molecular analysis of acid ceramidase deficiency in patients with Farber disease.
Molecular basis of acid ceramidase deficiency in a neonatal form of Farber disease: identification of the first large deletion in ASAH1 gene.
Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease.
Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue.
Neurodegenerative course in ceramidase deficiency (Farber disease) correlates with the residual lysosomal ceramide turnover in cultured living patient cells.
Neutral Ceramidase Mediates Nonalcoholic Steatohepatitis by Regulating Monounsaturated Fatty Acids and Gut IgA+ B Cells.
Novel biochemical abnormalities and genotype in Farber disease.
Novel V97G ASAH1 mutation found in Farber disease patients: Unique appearance of the disease with an intermediate severity, and marked early involvement of central and peripheral nervous system.
Pathological manifestations of Farber disease in a new mouse model.
Peripheral osteolysis in adults linked to ASAH1 (acid ceramidase) mutations: A new presentation of Farber disease.
Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency.
Sulfatide and sphingomyelin loading of living cells as tools for the study of ceramide turnover by lysosomal ceramidase--implications for the diagnosis of Farber disease.
Systemic ceramide accumulation leads to severe and varied pathological consequences.
Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress.
Tissue accumulation of sulfatide and GM3 ganglioside in a patient with variant Farber disease.
Transcriptional changes revealed genes and pathways involved in the deficient testis caused by the inhibition of alkaline ceramidase (Dacer) in Drosophila melanogaster.
[Farber disease [Farber lipogranulomatosis], acid ceramidase deficiency]
[Role of adiponectin in prostate cancer: A preliminary study].
Cerebellar Ataxia
Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.
Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.
Cerebral Hemorrhage
Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice.
Cerebral Infarction
Association between adiponectin receptor 2 gene polymorphisms and cerebral infarction.
Cerebrovascular Disorders
Administration of rCTRP9 Attenuates Neuronal Apoptosis Through AdipoR1/PI3K/Akt Signaling Pathway after ICH in Mice.
Cervical Intraepithelial Neoplasia
Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
Chemical and Drug Induced Liver Injury
Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis.
Chondrosarcoma
Involvement of AdipoR receptor in adiponectin-induced motility and alpha2beta1 integrin upregulation in human chondrosarcoma cells.
Colitis
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.
Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1.
Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.
Colitis, Ulcerative
Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment.
Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.
Colitis-Associated Neoplasms
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.
Colonic Neoplasms
Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and ?1 integrin/FAK-mediated signalling.
Adiponectin Represses Colon Cancer Cell Proliferation via AdipoR1- and -R2-Mediated AMPK Activation.
Adiponectin supports cell survival in glucose deprivation through enhancement of autophagic response in colorectal cancer cells.
AdipoRon Attenuates Wnt Signaling by Reducing Cholesterol-Dependent Plasma Membrane Rigidity.
AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells.
Effects of ceranib-2 on cell survival and TNF-alpha in colon cancer cell line.
Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue.
Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening.
Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
Role of neutral ceramidase in colon cancer.
[Serum adipokines and their receptors in endometrial and colon cancer patients: relationship with tumor invasion and metastasis].
Colorectal Neoplasms
Acid ceramidase is a novel drug target for pediatric brain tumors.
Adiponectin and adiponectin receptor in relation to colorectal cancer progression.
Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway.
Adiponectin receptor 2 is negatively associated with lymph node metastasis of colorectal cancer.
Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors.
AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells.
Association of adiponectin receptor (Adipo-R1/-R2) expression and colorectal cancer.
Association of adiponectin receptor 1 gene - 106 C > T variant with susceptibility to colorectal cancer.
Association of ADIPOQ and ADIPOR variants with risk of colorectal cancer: A meta-analysis.
Association of IGFBP-6 Expression with Metabolic Syndrome and Adiponectin and IGF-IR Receptor Levels in Colorectal Cancer.
Associations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study.
Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis.
Functions of neutral ceramidase in the Golgi apparatus.
Interactions between genetic variants in the adiponectin, adiponectin receptor 1 and environmental factors on the risk of colorectal cancer.
Reduced expression of the AdipoR1 gene is correlated with venous invasion in colorectal cancer.
Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.
Congenital Abnormalities
[A case report of childhood Farber's disease and literature review].
Coronary Artery Disease
Adiponectin receptor 1 and small ubiquitin-like modifier 4 polymorphisms are associated with risk of coronary artery disease without diabetes.
Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary artery disease patients?
Arterial stiffness is associated with increased monocyte expression of adiponectin receptor mRNA and protein in patients with coronary artery disease.
Common Haplotypes at the Adiponectin Receptor 1 (ADIPOR1) Locus Are Associated With Increased Risk of Coronary Artery Disease in Type 2 Diabetes.
Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes.
Manipulation of the Sphingolipid Rheostat Influences the Mediator of Flow-Induced Dilation in the Human Microvasculature.
Cystadenoma
[Study of the genes correlated with cyst calcification in patients with cystic echinococcosis].
Cystic Fibrosis
Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections.
Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice.
Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis.
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis.
Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell Lines.
Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.
Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis.
Dermatitis
Ceramidastin, a novel bacterial ceramidase inhibitor, produced by Penicillium sp. Mer-f17067.
Dermatitis, Atopic
Activation of bacterial ceramidase by anionic glycerophospholipids: possible involvement in ceramide hydrolysis on atopic skin by Pseudomonas ceramidase.
Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis.
Ceramidase activity in bacterial skin flora as a possible cause of ceramide deficiency in atopic dermatitis.
Citric acid inhibits a bacterial ceramidase and alleviates atopic dermatitis in an animal model.
Current status and perspectives in ceramide-targeting molecular medicine.
Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus.
Inhibitory Effect of Polyphenol-Rich Fraction from the Bark of Acacia mearnsii on Itching Associated with Allergic Dermatitis.
Oral supplementation of Lithospermum erythrorhizon prevents the development of atopic dermatitis with reducing ceramide degradation in the epidermis of NC/Nga mice.
Purification and characterization of a novel ceramidase from Pseudomonas aeruginosa.
Role of ceramides in barrier function of healthy and diseased skin.
Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the ?-Subunit of Acid Ceramidase.
Diabetes Complications
Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1.
Diabetes Insipidus
Identification of Acer2 as a First Susceptibility Gene for Lithium-Induced Nephrogenic Diabetes Insipidus in Mice.
Diabetes Insipidus, Nephrogenic
Identification of Acer2 as a First Susceptibility Gene for Lithium-Induced Nephrogenic Diabetes Insipidus in Mice.
Diabetes Mellitus
?-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.
Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese.
Current status and perspectives in ceramide-targeting molecular medicine.
Impact of 1,25(OH) 2 D 3 on TG content in liver of rats with type 2 diabetes.
Reduced adiponectin receptor signalling accelerates atherosclerosis and may worsen the outcome in type 2 diabetes mellitus - another one of those missing links?
Regulation of Adiponectin Receptor 2 Expression via PPAR-alpha in NIT-1 Cells.
Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes.
The Effects of Adiponectin and Adiponectin Receptor 1 Levels on Macrovascular Complications Among Patients with Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
A polymorphism in the gene encoding AdipoR1 affects olfactory recognition.
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.
Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.
Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes.
Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance.
Adiponectin receptor fragmentation in mouse models of type 1 and type 2 diabetes.
Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations.
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.
Adiponectin receptors gene expression in lymphocytes of obese and anorexic patients.
Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study.
Association of the +33371 A/G polymorphism in adiponectin receptor 2 gene with Type 2 diabetes in the Chinese population.
Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese.
Common Haplotypes at the Adiponectin Receptor 1 (ADIPOR1) Locus Are Associated With Increased Risk of Coronary Artery Disease in Type 2 Diabetes.
Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes.
Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1.
Genetic Analysis of ADIPOR1 and ADIPOR2 Candidate Polymorphisms for Type 2 Diabetes in the Caucasian Population.
Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.
Impact of 1,25(OH) 2 D 3 on TG content in liver of rats with type 2 diabetes.
In silico analysis of nonsynonymous single nucleotide polymorphisms of the human adiponectin receptor 2 (ADIPOR2) gene.
Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis.
Neutral Ceramidase Secreted Via Exosome Protects Against Palmitate-Induced Apoptosis in INS-1 Cells.
Pathophysiological mechanism of bone loss in type 2 diabetes involves inverse regulation of osteoblast function by PPAR? coactivator-1? and skeletal muscle atrogenes: adiponectin receptor 1 as a potential target for reversing diabetes-induced osteopenia.
Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance.
Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans.
Reduced adiponectin receptor signalling accelerates atherosclerosis and may worsen the outcome in type 2 diabetes mellitus - another one of those missing links?
Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes.
The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes.
The Effects of Adiponectin and Adiponectin Receptor 1 Levels on Macrovascular Complications Among Patients with Type 2 Diabetes Mellitus.
Utilization of electronic health records for the assessment of adiponectin receptor autoantibodies during the progression of cardio-metabolic comorbidities.
Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in women: a tagging-single nucleotide polymorphism haplotype analysis.
Diabetes, Gestational
Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines.
Diabetic Cardiomyopathies
Analysis of the association between adiponectin, adiponectin receptor 1 and diabetic cardiomyopathy.
Diabetic Nephropathies
Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy.
Erratum to: Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy.
Ezetimibe Ameliorates Early Diabetic Nephropathy in db/db Mice.
Mechanisms of Adiponectin Action: Implication of Adiponectin Receptor Agonism in Diabetic Kidney Disease.
Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy.
The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes.
Diverticulitis
Profiling adipocytokine secretion from creeping fat in Crohn's disease.
Drug Resistant Epilepsy
Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1.
Dyslipidemias
Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes.
Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.
Dystonia
ACER3-related leukoencephalopathy: expanding the clinical and imaging findings spectrum due to novel variants.
Eclampsia
Influence of serum HMW adiponectin level in patients with pregnancy-induced hypertension syndrome on the occurrence of eclampsia in secondary pregnancy.
Endometrial Neoplasms
Adiponectin mediates antiproliferative and apoptotic responses in endometrial carcinoma by the AdipoRs/AMPK pathway.
Clinicopathological roles of adiponectin and leptin receptors in endometrial carcinoma.
Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans.
Genetic polymorphisms in obesity-related genes and endometrial cancer risk.
[Effects of metformin and adiponectin on endometrial cancer cells growth].
Endometriosis
Expression of adiponectin, leptin, and their receptors in ovarian endometrioma.
in vitro Anti-Proliferative Effect of Adiponectin on Human Endometriotic Stromal Cells through AdipoR1 and AdipoR2 Gene Receptor Expression.
Endotoxemia
Identification and Characterization of a Novel Adiponectin Receptor Agonist AdipoAI and its Anti-Inflammatory Effects in vitro and in vivo.
Ependymoma
Genomics and epigenetics: A study of ependymomas in pediatric patients.
Pediatric ependymoma: GNAO1, ASAH1, IMMT and IPO7 protein expression and 5-year prognosis correlation.
Epilepsies, Myoclonic
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
Epilepsy
A new case of SMA phenotype without epilepsy due to biallelic variants in ASAH1.
Evidence for clinical, genetic and biochemical variability in spinal muscular atrophy with progressive myoclonic epilepsy.
Whole-exome sequencing broadens the phenotypic spectrum of rare pediatric epilepsy: a retrospective study.
Fabry Disease
Synthesis of novel internal standards for the quantitative determination of plasma ceramide trihexoside in Fabry disease by tandem mass spectrometry.
Farber Lipogranulomatosis
A fluorescence-based high-performance liquid chromatographic assay to determine acid ceramidase activity.
A high-performance liquid chromatographic assay for acid ceramidase activity in cultured fibroblasts from patients with Farber's disease and from controls.
A novel mutation in an atypical presentation of the rare infantile Farber disease.
A simple fluorogenic method for determination of acid ceramidase activity and diagnosis of Farber disease.
A simple method for screening for Farber disease on cultured skin fibroblasts.
A132: farber disease explains subset of juvenile idiopathic arthritis.
Abnormalities of lysosomes in human diploid fibroblasts from patients with Farber's disease.
Accumulation of Ordered Ceramide-Cholesterol Domains in Farber Disease Fibroblasts.
Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy.
Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.
Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities.
Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.
Acid ceramidase deficiency: Farber disease and SMA-PME.
Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content.
Acid ceramidase is a novel factor required for early embryo survival.
Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.
Allogeneic hematopoietic cell transplantation in Farber disease.
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in cultured skin fibroblasts from sphingolipidosis patients.
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in tissues from sphingolipidosis patients.
ASAH1 pathogenic variants associated with acid ceramidase deficiency: Farber disease and spinal muscular atrophy with progressive myoclonic epilepsy.
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
ASAH1-related disorders: Description of 15 novel pediatric patients and expansion of the clinical phenotype.
Atypical presentation of infantile-onset farber disease with novel ASAH1 mutations.
Autologous Transplantation of Lentivector/Acid Ceramidase-Transduced Hematopoietic Cells in Nonhuman Primates.
Bone marrow transplantation for infantile ceramidase deficiency (Farber disease).
C26-Ceramide as highly sensitive biomarker for the diagnosis of Farber Disease.
Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase.
Ceramidase deficiency in Farber's disease (lipogranulomatosis).
Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency.
Clinical diagnosis of a new case of ceramidase deficiency (Farber's disease).
Clinical features and genetics in non-5q spinal muscular atrophy caused by acid ceramidase deficiency.
Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency.
Development of an acid ceramidase activity-based probe.
Diagnosis of lipogranulomatosis (Farber disease) by use of cultured fibroblasts.
Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites.
Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner.
Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice.
Farber disease in a patient from China.
Farber disease: an ultrastructural study. Report of a case and review of the literature.
Farber disease: clinical presentation, pathogenesis and a new approach to treatment.
Farber lipogranulomatosis type 1 - Late presentation and early death in a Croatian boy with a novel homozygous ASAH1 mutation.
Farber lipogranulomatosis: clinical and molecular genetic analysis reveals a novel mutation in an Indian family.
Farber's disease (lysosomal acid ceramidase deficiency).
Farber's disease in two siblings, sural nerve and subcutaneous biopsies by light and electron microscopy.
Farber's lipogranulomatosis: ceramidase deficiency and prolonged survival in three relatives.
Generation of an induced pluripotent stem cell line (TRNDi030-A) from a patient with Farber disease carrying a homozygous p. Y36C (c. 107 A>G) mutation in ASAH1.
Hematopoietic stem cell transplant does not prevent neurological deterioration in infants with Farber disease: Case report and literature review.
Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency.
Human acid ceramidase gene: novel mutations in Farber disease.
Human acid ceramidase is overexpressed but not mutated in prostate cancer.
In vivo delivery of human acid ceramidase via cord blood transplantation and direct injection of lentivirus as novel treatment approaches for Farber disease.
Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide.
Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes.
Involvement of caspase-3 and GD3 ganglioside in ceramide-induced apoptosis in Farber disease.
Leukocyte and plasma N-laurylsphingosine deacylase (ceramidase) in Farber disease.
Metabolism of ceramide-containing endocytotic vesicles in human diploid fibroblasts.
Model SV40-transformed fibroblast lines for metabolic studies of human prosaposin and acid ceramidase deficiencies.
Molecular analyses of novel ASAH1 mutations causing Farber lipogranulomatosis: analyses of exonic splicing enhancer inactivating mutation.
Molecular analysis of acid ceramidase deficiency in patients with Farber disease.
Molecular basis of acid ceramidase deficiency in a neonatal form of Farber disease: identification of the first large deletion in ASAH1 gene.
Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease.
Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease.
My journey into the world of sphingolipids and sphingolipidoses.
Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue.
Neurodegenerative course in ceramidase deficiency (Farber disease) correlates with the residual lysosomal ceramide turnover in cultured living patient cells.
Novel biochemical abnormalities and genotype in Farber disease.
Novel manifestations of Farber disease mimicking neuronopathic Gaucher disease.
Novel V97G ASAH1 mutation found in Farber disease patients: Unique appearance of the disease with an intermediate severity, and marked early involvement of central and peripheral nervous system.
On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.
Overexpression and mass spectrometry analysis of mature human acid ceramidase.
Pathological manifestations of Farber disease in a new mouse model.
Peripheral osteolysis in adults linked to ASAH1 (acid ceramidase) mutations: A new presentation of Farber disease.
Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency.
Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells.
Spinal muscular atrophy and Farber disease due to ASAH1 variants: A case report.
Spinal muscular atrophy associated with progressive myoclonic epilepsy.
Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1.
Stress-induced apoptosis is not mediated by endolysosomal ceramide.
Structural basis for the activation of acid ceramidase.
Sulfatide and sphingomyelin loading of living cells as tools for the study of ceramide turnover by lysosomal ceramidase--implications for the diagnosis of Farber disease.
Surgical treatment of hand disorders in Farber's disease: a case report.
Systemic ceramide accumulation leads to severe and varied pathological consequences.
The in situ degradation of ceramide, a potential lipid mediator, is not completely impaired in Farber disease.
The reverse activity of human acid ceramidase.
The synthetic pathway for glucosylsphingosine in cultured fibroblasts.
Tissue accumulation of sulfatide and GM3 ganglioside in a patient with variant Farber disease.
Uniparental disomy as a cause of spinal muscular atrophy and progressive myoclonic epilepsy: Phenotypic homogeneity due to the homozygous c.125C>T mutation in ASAH1.
Zebrafish acid ceramidase: Expression in Pichia pastoris GS115and biochemical characterization.
[Farber disease [Farber lipogranulomatosis], acid ceramidase deficiency]
[Farber disease: a cause of hoarseness of the voice in children]
Fatty Liver
A polymorphism in the gene encoding AdipoR1 affects olfactory recognition.
Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis.
Adiponectin receptor 1 enhances fatty acid metabolism and cell survival in palmitate-treated HepG2 cells through the PI3 K/AKT pathway.
Adiponectin reduces connective tissue growth factor in human hepatocytes which is already induced in non-fibrotic non-alcoholic steatohepatitis.
Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease.
Downregulation of Adiponectin/AdipoR2 is Associated with Steatohepatitis in Obese Mice.
Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice.
Identification of protective components that prevent the exacerbation of goose fatty liver: Characterization, expression and regulation of adiponectin receptors.
Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children.
[The role of adiponectin and adiponectin receptor 2 in the pathology of fatty liver]
Fatty Liver, Alcoholic
Adiponectin: a key adipokine in alcoholic fatty liver.
Role of SIRT1-FoxO1 Signaling in Dietary Saturated Fat-Dependent Up-Regulation of Liver Adiponectin Receptor 2 in Ethanol-Administered Mice.
[Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease].
Follicular Cyst
Alterations in key metabolic sensors involved in bovine cystic ovarian disease.
Gastrointestinal Stromal Tumors
Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors.
Gaucher Disease
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in cultured skin fibroblasts from sphingolipidosis patients.
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in tissues from sphingolipidosis patients.
Properties of acid ceramidase from human spleen.
Genetic Diseases, Inborn
Acid ceramidase is a novel factor required for early embryo survival.
Involvement of caspase-3 and GD3 ganglioside in ceramide-induced apoptosis in Farber disease.
Glaucoma
Optic Nerve Lipidomics Reveal Impaired Glucosylsphingosine Lipids Pathway in Glaucoma.
Glioblastoma
Acid ceramidase and its inhibitors: a
Acid ceramidase confers radioresistance to glioblastoma cells.
Acid ceramidase is a novel drug target for pediatric brain tumors.
AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway.
Development of second generation peptides modulating cellular adiponectin receptor responses.
Molecular mechanism of inhibition of acid ceramidase by carmofur.
Molecular Targeting of Acid Ceramidase in Glioblastoma: A Review of Its Role, Potential Treatment, and Challenges.
Glioma
AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway.
Comparison of a ceramidase inhibitor (ceranib-2) with C2 ceramide and cisplatin on cytotoxicity and apoptosis of glioma cells.
p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis.
Glucose Intolerance
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.
Adiponectin receptors gene expression in lymphocytes of obese and anorexic patients.
Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study.
Fish oil consumption prevents glucose intolerance and hypercorticosteronemy in footshock-stressed rats.
Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training.
Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis.
Granuloma
An autopsy case of Farber's lipogranulomatosis in a Japanese boy with gastrointestinal involvement.
Head and Neck Neoplasms
Targeting acid ceramidase sensitises head and neck cancer to cisplatin.
Heart Failure
AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload.
MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure.
Hematologic Neoplasms
Ceramidases in Hematological Malignancies: Senseless Or Neglected Target?
Hepatitis
Adiponectin receptor agonist AdipoRon relieves endotoxin-induced acute hepatitis in mice.
Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis.
Hepatitis C
Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis.
Hepatomegaly
Role of pregnane X receptor in obesity and glucose homeostasis in male mice.
Herpes Simplex
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.
Herpes Zoster
Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas.
Hoarseness
Surgical treatment of hand disorders in Farber's disease: a case report.
[A case report of childhood Farber's disease and literature review].
Hyperglycemia
Adiponectin Receptor Agonist, AdipoRon, Causes Vasorelaxation Predominantly Via a Direct Smooth Muscle Action.
Black Soybean Leaf Extract Suppresses Hyperglycemia and Hepatic Steatosis by Enhancing Adiponectin Receptor Signaling and AMPK Activation.
Endothelial acid ceramidase in exosome-mediated release of NLRP3 inflammasome products during hyperglycemia: Evidence from endothelium-specific deletion of Asah1 gene.
High-fat diet and glucocorticoid treatment cause hyperglycemia associated with adiponectin receptor alterations.
Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts.
Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis.
Pioglitazone prevents hyperglycemia induced decrease of AdipoR1 and AdipoR2 in coronary arteries and coronary VSMCs.
Hyperinsulinism
Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts.
Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line.
Role of pregnane X receptor in obesity and glucose homeostasis in male mice.
Hypertension
Adiponectin and its receptors are involved in hypertensive vascular injury.
Novel effect of adenosine 5'-monophosphate on ameliorating hypertension and the metabolism of lipids and glucose in stroke-prone spontaneously hypertensive rats.
Hyperthyroidism
AdipoR1 and AdipoR2 gene expression are regulated by thyroid hormones in adipose tissue.
Hypertriglyceridemia
Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population.
Infections
Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections.
CORRELATION OF HELICOBACTER PYLORI INFECTION WITH DEVELOPMENT OF CARDIOVASCULAR RISK IN PATIENTS WITH CORONARY HEART DISEASE IN ASSOCIATION WITH TYPE 2 DIABETES MELLITUS.
Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets.
Identification and biochemical characterization of Laodelphax striatellus neutral ceramidase.
Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis.
Overexpression and mass spectrometry analysis of mature human acid ceramidase.
Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of ?-toxin.
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis.
Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell Lines.
Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.
Sphingosine rescues burn-injured mice from pulmonary Pseudomonas aeruginosa infection.
Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis.
Inflammatory Bowel Diseases
Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowel disease.
Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.
Insulin Resistance
A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome.
A polymorphism in the gene encoding AdipoR1 affects olfactory recognition.
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.
A Variant in ADIPOR2 Is Associated with Increased Free Fatty Acid Levels in Chinese Population.
Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.
Abundance of adiponectin system and G-protein coupled receptor GPR109A mRNA in adipose tissue and liver of F2 offspring cows of Charolais × German Holstein crosses that differ in body fat accumulation.
Activation of the LH receptor up regulates the type 2 adiponectin receptor in human granulosa cells.
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
Adiponectin and adiponectin receptors in obesity-linked insulin resistance.
Adiponectin and Cognitive Decline.
Adiponectin and its Hydrolase-Activated Receptors.
Adiponectin and its receptors are expressed in the chicken testis: influence of sexual maturation on testicular ADIPOR1 and ADIPOR2 mRNA abundance.
Adiponectin and its receptors in patients with chronic hepatitis C.
Adiponectin is secreted by theca layer cells isolated from chicken ovarian follicles.
Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance.
Adiponectin receptor 1 variants associated with lower insulin resistance in African Americans.
Adiponectin receptor 2 expression in liver and insulin resistance in db/db mice given a beta3-adrenoceptor agonist.
Adiponectin Receptor Agonist, AdipoRon, Causes Vasorelaxation Predominantly Via a Direct Smooth Muscle Action.
Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations.
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.
Adiponectin receptors gene expression in lymphocytes of obese and anorexic patients.
Adiponectin Regulation and Function.
Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice.
Adiponectin, Leptin, and Insulin-Pathway Receptors as Endometrial Cancer Subtyping Markers.
Adiponectin, skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone.
Adiponectin--a key adipokine in the metabolic syndrome.
AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells.
AdipoRon, adiponectin receptor agonist, improves vascular function in the mesenteric arteries of type 2 diabetic mice.
AdR1-TG/TALLYHO mice have improved lipid accumulation and insulin sensitivity.
Aerobic training increases the expression of adiponectin receptor genes in the peripheral blood mononuclear cells of young men.
ANGIOTENSIN CONVERTING ENZYME INHIBITORS IMPROVE HEPATIC STEATOSIS BY MODULATING EXPRESSION OF TUMOR NECROSIS FACTOR-Alpha, INTERLEUKIN-6 AND ADIPONECTIN RECEPTOR-2 IN RATS WITH TYPE 2 DIABETES.
Association between adiponectin receptor 1 gene polymorphism and insulin resistance in Chinese patients with polycystic ovary syndrome.
Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.
Association of adiponectin receptor 1 gene - 106 C > T variant with susceptibility to colorectal cancer.
Association of ADIPOR2 with liver function tests in type 2 diabetic subjects.
Association of Native American ancestry and common variants in ACE, ADIPOR2, MTNR1B, GCK, TCF7L2 and FTO genes with glycemic traits in Colombian population.
Association of single nucleotide polymorphisms in adiponectin and its receptor genes with polycystic ovary syndrome.
Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study.
beta-adrenoceptor agonists downregulate adiponectin, but upregulate adiponectin receptor 2 and tumor necrosis factor-alpha expression in adipocytes.
Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes.
Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training.
Correlation of adiponectin receptor expression with cytokines and insulin sensitivity in growth hormone (GH)-treated children with Prader-Willi syndrome and in non-GH-treated obese children.
Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes.
Dietary Conjugated Linoleic Acid Lowered Tumor Necrosis Factor-alpha Content and Altered Expression of Genes Related to Lipid Metabolism and Insulin Sensitivity in the Skeletal Muscle of Zucker Rats.
Dietary supplement of conjugated linoleic acids or polyunsaturated fatty acids suppressed the mobilization of body fat reserves in dairy cows at early lactation through different pathways.
Effects of adrenal hormones on the expression of adiponectin and adiponectin receptors in adipose tissue, muscle and liver.
Effects of probucol on hepatic tumor necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 expression in diabetic rats.
Exercise Training Improves Whole Body Insulin Resistance via Adiponectin Receptor 1.
Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism.
Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training.
Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance.
Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.
Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes.
Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signalling pathways.
Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes.
Hydrodynamic delivery of adiponectin and adiponectin receptor 2 gene blocks high-fat diet-induced obesity and insulin resistance.
Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis.
Influence of insulin resistance on adiponectin receptor expression in breast cancer.
Influence of serum HMW adiponectin level in patients with pregnancy-induced hypertension syndrome on the occurrence of eclampsia in secondary pregnancy.
Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress.
Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer's Like Pathology in Mice Brain.
Overexpression of the Adiponectin Receptor AdipoR1 in Rat Skeletal Muscle Amplifies Local Insulin Sensitivity.
PEG-BHD1028 Peptide Regulates Insulin Resistance and Fatty Acid ?-Oxidation, and Mitochondrial Biogenesis by Binding to Two Heterogeneous Binding Sites of Adiponectin Receptors, AdipoR1 and AdipoR2.
PEROXIREDOXIN 4 PROTECTS AGAINST NONALCOHOLIC STEATOHEPATITIS AND TYPE 2 DIABETES IN A NONGENETIC MOUSE MODEL.
Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases.
Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial.
Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance.
Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat.
Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans.
Porcine adiponectin receptor 1 transgene resists high-fat/sucrose diet-induced weight gain, hepatosteatosis and insulin resistance in mice.
Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice.
Responsiveness to peripherally administered melanocortins in lean and obese mice.
RNA-binding protein PTB and microRNA-221 coregulate AdipoR1 translation and adiponectin signaling.
Role of adiponectin system in insulin resistance.
Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes.
Statin reverses reduction of adiponectin receptor expression in infarcted heart and in TNF-alpha-treated cardiomyocytes in association with improved glucose uptake.
Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis.
The -8503 G/A polymorphism of the adiponectin receptor 1 gene is associated with insulin sensitivity dependent on adiposity.
The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats.
The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.
The insulin sensitizing effects of PPAR-? agonist are associated to changes in adiponectin index and adiponectin receptors in Zucker fatty rats.
The relationship between -8503G/A polymorphism of adiponectin receptor 1 and insulin sensitivity in the Japanese population.
Undernutrition during suckling in rats elevates plasma adiponectin and its receptor in skeletal muscle regardless of diet composition: a protective effect?
[Effects of lotus leaf on inflammatory factors and liver AdipoR2 expressions in rats with NAFLD induced by high fat diet and high glucose].
[Relationship between adiponectin receptor 1 gene -3881T/C variant and glucose metabolism in the Chinese]
Intellectual Disability
Population genetic analysis of the N-acylsphingosine amidohydrolase gene associated with mental activity in humans.
Iron Overload
Iron overload reduces adiponectin receptor expression via a ROS/FOXO1-dependent mechanism leading to adiponectin resistance in skeletal muscle cells.
Ischemic Stroke
Association between adiponectin receptor 2 gene polymorphisms and cerebral infarction.
Association between microRNA binding site polymorphisms in immunoinflammatory genes and recurrence risk of ischemic stroke.
Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death.
Relationship between adiponectin receptor 1 gene polymorphisms and ischemic stroke.
Keloid
Identification of ASAH1 as a susceptibility gene for familial keloids.
Kidney Failure, Chronic
Adiponectin receptor and adiponectin signaling in human tissue among patients with end-stage renal disease.
Kidney Neoplasms
Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Lentivirus Infections
Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling.
Leukemia
ACER3 supports development of acute myeloid leukemia.
Current status and perspectives in ceramide-targeting molecular medicine.
IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia.
Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Aberrant expressions of leptin and adiponectin receptor isoforms in chronic myeloid leukemia patients.
Adiponectin signals through Adiponectin Receptor 1 to reverse imatinib resistance in K562 human chronic myeloid leukemia cells.
Leukemia, Myeloid, Acute
ACER3 supports development of acute myeloid leukemia.
Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-?B-dependent P-glycoprotein upregulation.
Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia - Impact on enzyme activity and response to cytotoxics.
The emergence of acid ceramidase as a therapeutic target for acute myeloid leukemia.
Leukodystrophy, Globoid Cell
Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target.
Lipid-Conjugated Rigidochromic Probe Discloses Membrane Alteration in Model Cells of Krabbe Disease.
Leukoencephalopathies
ACER3-related leukoencephalopathy: expanding the clinical and imaging findings spectrum due to novel variants.
Deficiency of alkaline ceramidase 3 with infancy-onset progressive leukoencephalopathy: a second case report.
Lipid Metabolism Disorders
[Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease].
Lipodystrophy
Polymorphisms in adiponectin receptor genes are associated with lipodystrophy-related phenotypes in HIV-infected patients receiving antiretroviral therapy.
Liver Cirrhosis
Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis.
Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats.
The role of AdipoR1 and AdipoR2 in liver fibrosis.
Liver Diseases
Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis.
Association of ADIPOR2 with liver function tests in type 2 diabetic subjects.
Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease.
Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children.
[Correlation of polymorphisms of adiponectin receptor 2 gene +33371Gln/Arg, cytochrome P4502E1 gene Rsa I and smoking with nonalcoholic fatty liver disease].
[Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease].
[The role of adiponectin and adiponectin receptor 2 in the pathology of fatty liver]
Liver Neoplasms
Adiponectin receptor R1 is upregulated by valproic acid but not by topiramate in human hepatoma cell line, HepG2.
Lung Diseases
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis.
Lung Injury
Chronic Intermittent Hypoxia in Premature Infants: The Link Between Low Fat Stores, Adiponectin Receptor Signaling and Lung Injury.
Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency.
Lung Neoplasms
Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase ? inhibition.
Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.
Genetic and pharmacological inhibition of acid ceramidase prevents asymmetric cell division by neosis.
Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Single nucleotide polymorphisms in VTI1A gene contribute to the susceptibility of Chinese population to non-small cell lung cancer.
Transcriptome analysis reveals gender-specific differences in overall metabolic response of male and female patients in lung adenocarcinoma.
Lymphatic Metastasis
Adiponectin receptor 2 is negatively associated with lymph node metastasis of colorectal cancer.
Associations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study.
Lysosomal Storage Diseases
Bone marrow transplantation for infantile ceramidase deficiency (Farber disease).
Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease.
Macular Degeneration
Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population.
Malnutrition
Adiponectin receptor 2 is regulated by nutritional status, leptin and pregnancy in a tissue-specific manner.
Periconceptional undernutrition modifies endocrine profiles and hepatic gene expression in sheep.
Undernutrition during suckling in rats elevates plasma adiponectin and its receptor in skeletal muscle regardless of diet composition: a protective effect?
Measles
Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro.
Medulloblastoma
Acid ceramidase is a novel drug target for pediatric brain tumors.
Melanoma
A bioinformatic approach to the identification of candidate genes for the development of new cancer diagnostics.
Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells.
Acid ceramidase controls apoptosis and increases autophagy in human melanoma cells treated with doxorubicin.
Acid ceramidase expression modulates the sensitivity of a375 melanoma cells to dacarbazine.
Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION.
Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes.
Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells.
Lysosomal acid ceramidase ASAH1 controls the transition between invasive and proliferative phenotype in melanoma cells.
Molecular mechanism of inhibition of acid ceramidase by carmofur.
N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production.
Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells.
Melanoma, Experimental
Enzymatic synthesis of omega-amino-ceramide: preparation of a sensitive fluorescent substrate for ceramidase.
Metabolic Diseases
Adiponectin receptor 1 C-terminus interacts with PDZ-domain proteins such as syntrophins.
Effects of the adiponectin mimetic compound ALY688 on glucose and fat metabolism in visceral and subcutaneous rat adipocytes.
Impacts of Nonsynonymous Single Nucleotide Polymorphisms of Adiponectin Receptor 1 Gene on Corresponding Protein Stability: A Computational Approach.
Metabolic Syndrome
A Variant Upstream of the CDH13 Adiponectin Receptor Gene and Metabolic Syndrome in Swedes.
Adiponectin and adiponectin receptors.
Adiponectin concentration in plasma is associated with muscle fiber size in healthy middle-aged men.
Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression.
Circadian expression of adiponectin and its receptors in human adipose tissue.
Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance.
Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.
Intra-abdominal fat adiponectin receptors expression and cardiovascular metabolic risk factors in obesity and diabetes.
Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases.
Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes.
[Serum adipokines and their receptors in endometrial and colon cancer patients: relationship with tumor invasion and metastasis].
Motor Neuron Disease
Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy.
Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency.
Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1.
Multiple Myeloma
[Adiponectin Receptor Agonist AdipoRon Inhibits the Proliferation of Myeloma Cells via the AMPK/Autophagy Pathway].
Muscle Weakness
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1.
Muscular Atrophy
ASAH1-related disorders: Description of 15 novel pediatric patients and expansion of the clinical phenotype.
Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy.
Muscular Atrophy, Spinal
Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy.
Acid ceramidase deficiency: Farber disease and SMA-PME.
Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content.
ASAH1 pathogenic variants associated with acid ceramidase deficiency: Farber disease and spinal muscular atrophy with progressive myoclonic epilepsy.
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
Clinical features and genetics in non-5q spinal muscular atrophy caused by acid ceramidase deficiency.
Evidence for clinical, genetic and biochemical variability in spinal muscular atrophy with progressive myoclonic epilepsy.
Eyelid myoclonic status epilepticus: A rare phenotype in spinal muscular atrophy with progressive myoclonic epilepsy associated with ASAH1 gene mutation.
Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency.
Spinal muscular atrophy and Farber disease due to ASAH1 variants: A case report.
Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1.
Spinal muscular atrophy associated with progressive myoclonic epilepsy: A rare condition caused by mutations in ASAH1.
Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1.
Structural basis for the activation of acid ceramidase.
Uniparental disomy as a cause of spinal muscular atrophy and progressive myoclonic epilepsy: Phenotypic homogeneity due to the homozygous c.125C>T mutation in ASAH1.
Whole-transcriptome sequencing in blood provides a diagnosis of spinal muscular atrophy with progressive myoclonic epilepsy.
Zebrafish acid ceramidase: Expression in Pichia pastoris GS115and biochemical characterization.
Myocardial Infarction
Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart.
Susceptibility of multiple polymorphisms in ADIPOQ, ADIPOR1 and ADIPOR2 genes to myocardial infarction in Han Chinese.
Myocardial Ischemia
Production and metabolism of ceramide in normal and ischemic-reperfused myocardium of rats.
Myocarditis
Adiponectin replacement therapy attenuates myocardial damage in leptin-deficient mice with viral myocarditis.
Impaired expression of cardiac adiponectin in leptin-deficient mice with viral myocarditis.
Myoclonic Epilepsies, Progressive
A novel case report of spinal muscular atrophy with progressive myoclonic epilepsy from Iran.
Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy.
Acid ceramidase deficiency: Farber disease and SMA-PME.
Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content.
ASAH1 pathogenic variants associated with acid ceramidase deficiency: Farber disease and spinal muscular atrophy with progressive myoclonic epilepsy.
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
ASAH1-related disorders: Description of 15 novel pediatric patients and expansion of the clinical phenotype.
Clinical features and genetics in non-5q spinal muscular atrophy caused by acid ceramidase deficiency.
Evidence for clinical, genetic and biochemical variability in spinal muscular atrophy with progressive myoclonic epilepsy.
Eyelid myoclonic status epilepticus: A rare phenotype in spinal muscular atrophy with progressive myoclonic epilepsy associated with ASAH1 gene mutation.
Polyarticular Arthritis and Spinal Muscular Atrophy in Acid Ceramidase Deficiency.
Spinal muscular atrophy and Farber disease due to ASAH1 variants: A case report.
Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1.
Spinal muscular atrophy associated with progressive myoclonic epilepsy: A rare condition caused by mutations in ASAH1.
Spinal muscular atrophy with progressive myoclonic epilepsy linked to mutations in ASAH1.
Structural basis for the activation of acid ceramidase.
Uniparental disomy as a cause of spinal muscular atrophy and progressive myoclonic epilepsy: Phenotypic homogeneity due to the homozygous c.125C>T mutation in ASAH1.
Zebrafish acid ceramidase: Expression in Pichia pastoris GS115and biochemical characterization.
Neoplasm Metastasis
Acid ceramidase as a therapeutic target in metastatic prostate cancer.
Acid Ceramidase; A Novel Therapeutic Target in Cancer.
Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2.
Adiponectin receptor 2 is negatively associated with lymph node metastasis of colorectal cancer.
LncRNA KCNQ1OT1 inhibits the radiosensitivity and promotes the tumorigenesis of hepatocellular carcinoma via the miR-146a-5p/ACER3 axis.
N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production.
Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer.
The value of detection of S100A8 and ASAH1 in predicting the chemotherapy response for breast cancer patients.
[Expression and Clinical Significance of Progesterone and Adiponectin Receptor Family Member 3 in Lung Cancer].
Neoplasms
A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy.
Acid Ceramidase (AC)-A Key Enzyme of Sphingolipid Metabolism-Correlates With Better Prognosis in Epithelial Ovarian Cancer.
Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.
Acid ceramidase and its inhibitors: a
Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase ? inhibition.
Acid ceramidase as a therapeutic target in metastatic prostate cancer.
Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.
Acid ceramidase expression modulates the sensitivity of a375 melanoma cells to dacarbazine.
Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and ?1 integrin/FAK-mediated signalling.
Acid ceramidase inhibition: a novel target for cancer therapy.
Acid ceramidase is a novel drug target for pediatric brain tumors.
Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.
Acid Ceramidase Promotes Nuclear Export of PTEN through Sphingosine 1-Phosphate Mediated Akt Signaling.
Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy.
Acid ceramidase, a double-edged sword in cancer aggression: A minireview.
Acid ceramidase, an emerging target for anti-cancer and anti-angiogenesis.
Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through up-regulation of cathepsin B.
Acid Ceramidase; A Novel Therapeutic Target in Cancer.
Acute adiponectin delivery is cardioprotective in the aged female rat heart.
Adipo-R1 and adipo-R2 expression in colorectal adenomas and carcinomas.
Adipokines expression and epithelial cell polarity in normal and cancerous breast tissue.
Adiponectin and adiponectin receptor in relation to colorectal cancer progression.
Adiponectin as a biomarker linking obesity and adiposopathy to hematologic malignancies.
Adiponectin inhibits tumor necrosis factor-?-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.
Adiponectin receptor 1 (ADIPOR1) rs1342387 polymorphism and risk of cancer: a meta-analysis.
Adiponectin receptor 1 gene is potentially associated with severity of postoperative pain but not cancer pain.
Adiponectin receptor 2 is negatively associated with lymph node metastasis of colorectal cancer.
Adiponectin receptor expression in gastric carcinoma: implications in tumor development and progression.
Adiponectin receptor expression in human malignant tissues.
Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors.
Adiponectin Receptor Expression Predicts Favorable Prognosis in Cases of Hepatocellular Carcinoma.
Adiponectin Reverses the Proliferative Effects of Estradiol and IGF-1 in Human Epithelial Ovarian Cancer Cells by Downregulating the Expression of Their Receptors.
Adiponectin, Leptin, and Insulin-Pathway Receptors as Endometrial Cancer Subtyping Markers.
AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway.
AdipoRon and Other Adiponectin Receptor Agonists as Potential Candidates in Cancer Treatments.
AdipoRon: a possible drug for colorectal cancer prevention?
AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells.
Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis.
Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells.
Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response.
Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation.
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.
Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling.
Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.
Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase.
Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis.
Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters.
Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma.
Associations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study.
Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide.
beta-adrenoceptor agonists downregulate adiponectin, but upregulate adiponectin receptor 2 and tumor necrosis factor-alpha expression in adipocytes.
Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen.
Ceramidases in Hematological Malignancies: Senseless Or Neglected Target?
Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells.
Ceramide mediates tumor-induced dendritic cell apoptosis.
Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver.
Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphenols and melanoidins.
Comparison of a ceramidase inhibitor (ceranib-2) with C2 ceramide and cisplatin on cytotoxicity and apoptosis of glioma cells.
Current status and perspectives in ceramide-targeting molecular medicine.
Cytotoxicities and Quantitative Structure Activity Relationships of B13 Sulfonamides in HT-29 and A549 Cells.
Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway.
Design and development of a peptide-based adiponectin receptor agonist for cancer treatment.
Dietary factors and cancer chemoprevention: an overview of obesity-related malignancies.
Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation.
Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cells.
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity.
Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites.
Endotoxin-induced myocardial dysfunction: evidence for a role of sphingosine production.
Expression and Biologic Significance of Adiponectin Receptors in Papillary Thyroid Carcinoma.
Expression levels of adiponectin receptors and periodontitis.
Expression of adiponectin and its receptors in swine.
Expression of adiponectin and its receptors is altered in epithelial ovarian tumors and ascites-derived ovarian cancer cell lines.
Expression of adiponectin and leptin receptors in adrenal incidentaloma patients with subclinical hormone secretion.
Expression of adiponectin receptors 1 and 2 and the leptin receptor in human adrenal tumors.
Expression of AdipoR1 and AdipoR2 Receptors as Leptin-Breast Cancer Regulation Mechanisms.
Gene expression of adipokines and adipokine receptors in the tumor microenvironment: associations of lower expression with more aggressive breast tumor features.
Genetic analysis of ADIPOQ variants and gastric cancer risk: a hospital-based case-control study in China.
Genetic and pharmacological inhibition of acid ceramidase prevents asymmetric cell division by neosis.
Genetic polymorphisms in obesity-related genes and endometrial cancer risk.
Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes.
Human acid ceramidase is overexpressed but not mutated in prostate cancer.
Human alkaline ceramidase 2 promotes the growth, invasion, and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid-like 3B.
Identification of ASAH1 as a susceptibility gene for familial keloids.
Impact of AdipoR1 expression on breast cancer development.
Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells.
Inhibitors of Ceramidases.
Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy-generated vaccine.
Leptin and adiponectin receptor expression in oesophageal cancer.
Lower plasma adiponectin levels are associated with larger tumor size and metastasis in clear-cell carcinoma of the kidney.
Measurement of ceramide and sphingolipid metabolism in tumors: potential modulation of chemotherapy.
Mechanistic insights into ceramidase inhibitor LCL521-enhanced tumor cell killing by photodynamic and thermal ablation therapies.
microRNA-423-3p promotes tumor progression via modulation of AdipoR2 in laryngeal carcinoma.
Molecular mechanism of inhibition of acid ceramidase by carmofur.
Molecular targeting of acid ceramidase: implications to cancer therapy.
Molecular targeting of obesity pathways in cancer.
N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production.
Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer.
New insights on the use of desipramine as an inhibitor for acid ceramidase.
No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk.
Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer.
Novel off-target effect of tamoxifen - Inhibition of acid ceramidase activity in cancer cells.
Obesity enhances sepsis-induced liver inflammation and injury in mice.
Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice.
Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death.
Overexpression of Adiponectin Receptors in Opium Users with and without Cancer.
Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study.
Pediatric pineal germinomas: Epigenetic and genomic approach.
Perinatal ciclosporin A exposure elicits sex-related cardiac dysfunction and inflammation in the rat progeny.
Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo.
Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk.
Potent inhibition of Acid ceramidase by novel B-13 analogues.
Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.
Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.
Rapid screening of specific changes in mRNA in thyroid carcinomas by sequence specific-differential display: decreased expression of acid ceramidase mRNA in malignant and benign thyroid tumors.
Reduced expression of the AdipoR1 gene is correlated with venous invasion in colorectal cancer.
Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line.
Renoprotective effect of a combination of garlic and telmisartan against ischemia/reperfusion-induced kidney injury in obese rats.
Role of adiponectin receptors, AdipoR1 and AdipoR2, in the steroidogenesis of the human granulosa tumor cell line, KGN.
Role of neutral ceramidase in colon cancer.
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.
Roles of Adiponectin Signaling Related Proteins in Mammary Tumor Development.
Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer.
Sphingo-guanidines and their use as inhibitors of sphingosine kinase (WO2010078247).
Sphingolipids and acid ceramidase as therapeutic targets in cancer therapy.
Sphingolipids and response to chemotherapy.
Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.
Structural basis for the activation of acid ceramidase.
Synthesis and bioevaluation of omega-N-amino analogs of B13.
Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases.
Tamoxifen is a candidate first-in-class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells-Unrecognized players in tumorigenesis.
Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.
Targeting acid ceramidase sensitises head and neck cancer to cisplatin.
Targeting ceramide metabolic pathway induces apoptosis in human breast cancer cell lines.
Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy.
The Functional Effects of Acid Ceramidase Overexpression in Prostate Cancer Progression and Resistance to Chemotherapy.
The investigation of ceranib-2 on apoptosis and drug interaction with carboplatin in human non small cell lung cancer cells in vitro.
The role of adiponectin in cancer: a review of current evidence.
The value of detection of S100A8 and ASAH1 in predicting the chemotherapy response for breast cancer patients.
Three ADIPOR1 Polymorphisms and Cancer Risk: A Meta-Analysis of Case-Control Studies.
Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies.
Transcriptome analysis reveals gender-specific differences in overall metabolic response of male and female patients in lung adenocarcinoma.
Tumor expression of adiponectin receptor 2 and lethal prostate cancer.
Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.
Zinc-alpha2-glycoprotein: a new biomarker of breast cancer?
[14C]ceramide synthesis by sphingolipid ceramide N-deacylase: new assay for ceramidase activity detection.
[Expression and Clinical Significance of Progesterone and Adiponectin Receptor Family Member 3 in Lung Cancer].
[Serum adipokines and their receptors in endometrial and colon cancer patients: relationship with tumor invasion and metastasis].
Nephrotic Syndrome
Abnormal podocyte TRPML1 channel activity and exosome release in mice with podocyte-specific Asah1 gene deletion.
Podocytopathy and Nephrotic Syndrome in Mice with Podocyte-Specific Deletion of the Asah1 Gene: Role of Ceramide Accumulation in Glomeruli.
Nervous System Malformations
Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities.
Neuroblastoma
Role of down-regulated neutral ceramidase during all-trans retinoic acid-induced neuronal differentiation in SH-SY5Y neuroblastoma cells.
Neurodegenerative Diseases
Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices.
Neuroinflammatory Diseases
Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice.
Neurologic Manifestations
ACER3-related leukoencephalopathy: expanding the clinical and imaging findings spectrum due to novel variants.
Peripheral osteolysis in adults linked to ASAH1 (acid ceramidase) mutations: A new presentation of Farber disease.
Neuroma
Regular Swimming Exercise Attenuated Neuroma Pain in Rats: Involvement of Leptin and Adiponectin.
Niemann-Pick Disease, Type C
Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation.
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in cultured skin fibroblasts from sphingolipidosis patients.
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in tissues from sphingolipidosis patients.
Niemann-Pick Diseases
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in cultured skin fibroblasts from sphingolipidosis patients.
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in tissues from sphingolipidosis patients.
Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase.
Non-alcoholic Fatty Liver Disease
Correction: Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress.
Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease.
Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice.
Neutral Ceramidase Mediates Nonalcoholic Steatohepatitis by Regulating Monounsaturated Fatty Acids and Gut IgA+ B Cells.
Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line.
Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis.
Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children.
Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress.
The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats.
[Correlation of polymorphisms of adiponectin receptor 2 gene +33371Gln/Arg, cytochrome P4502E1 gene Rsa I and smoking with nonalcoholic fatty liver disease].
[Effects of lotus leaf on inflammatory factors and liver AdipoR2 expressions in rats with NAFLD induced by high fat diet and high glucose].
Obesity
A potential determinant role of adiponectin and receptors for the early embryo development in PCOS patients with obesity hinted by quantitative profiling.
Adipokines expression and epithelial cell polarity in normal and cancerous breast tissue.
Adiponectin and adiponectin receptor 1 expression proteins levels are modified in breast cancer in postmenopausal women with obesity.
Adiponectin receptors gene expression in lymphocytes of obese and anorexic patients.
Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots.
Adiponectin, adiponectin receptors, and epigenetic regulation of adipogenesis.
ADIPOQ and ADIPOR2 gene polymorphisms: association with overweight/obesity in Mexican children.
ADIPOQ, ADIPOR1, and ADIPOR2 Polymorphisms in Relation to Serum Adiponectin Levels and BMI in Black and White Women.
Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression.
Association of adiponectin receptor 1 gene - 106 C > T variant with susceptibility to colorectal cancer.
Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes.
Childhood obesity: current situation in Mexico.
Danthron ameliorates obesity and MAFLD through activating the interplay between PPAR?/RXR? heterodimer and adiponectin receptor 2.
Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study.
Effects of Obesity on Adiponectin System Skin Expression in Dogs: A Comparative Study.
Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1.
Expression of Adiponectin and its Receptors in the Porcine Hypothalamus During the Oestrous Cycle.
Expression of AdipoR1 and AdipoR2 Receptors as Leptin-Breast Cancer Regulation Mechanisms.
Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training.
Hepatic adiponectin receptors (ADIPOR) 1 and 2 mRNA and their relation to insulin resistance in obese humans.
Hydrodynamic delivery of adiponectin and adiponectin receptor 2 gene blocks high-fat diet-induced obesity and insulin resistance.
Hypothalamic gene expression underlying pre-hibernation satiety.
In silico analysis of nonsynonymous single nucleotide polymorphisms of the human adiponectin receptor 2 (ADIPOR2) gene.
Intra-abdominal fat adiponectin receptors expression and cardiovascular metabolic risk factors in obesity and diabetes.
Leptin and adiponectin receptor expression in oesophageal cancer.
Lung Regulatory T Cells Express Adiponectin Receptor 1: Modulation by Obesity and Airway Allergic Inflammation.
No conclusive evidence for association of polymorphisms in the adiponectin receptor 1 gene, AdipoR1, with common obesity.
Obesity enhances sepsis-induced liver inflammation and injury in mice.
Obesity: Adiponectin receptor agonists--possible therapeutic approach?
Pattern of expression of adiponectin receptors in human adipose tissue depots and its relation to the metabolic state.
Pattern of Expression of Adiponectin Receptors in Human Liver and its Relation to Nonalcoholic Steatohepatitis.
Protracted Upregulation of Leptin and IGF1 is Associated with Activation of PI3K/Akt and JAK2 Pathway in Mouse Intestine after Ionizing Radiation Exposure.
Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice.
Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line.
Responsiveness to peripherally administered melanocortins in lean and obese mice.
Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters.
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
The adiponectin receptor agonist AdipoRon normalizes glucose metabolism and prevents obesity but not growth retardation induced by glucocorticoids in young mice.
The insulin sensitizing effects of PPAR-? agonist are associated to changes in adiponectin index and adiponectin receptors in Zucker fatty rats.
The story of adiponectin and its receptors AdipoR1 and R2: To follow.
Tumor expression of adiponectin receptor 2 and lethal prostate cancer.
Obesity, Abdominal
Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma.
Circadian expression of adiponectin and its receptors in human adipose tissue.
Obesity, Maternal
Effects of maternal obesity on maternal and fetal plasma concentrations of adiponectin and expression of adiponectin and its receptor genes in cotyledonary and adipose tissues at mid- and late-gestation in sheep.
Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta.
Osteoarthritis
Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappaB pathway.
Adiponectin receptor 1 mediates the difference in adiponectin- induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts.
Adiponectin receptor agonist AdipoRon attenuates calcification of osteoarthritis chondrocytes by promoting autophagy.
Osteolysis
Peripheral osteolysis in adults linked to ASAH1 (acid ceramidase) mutations: A new presentation of Farber disease.
Ovarian Neoplasms
Adiponectin receptor agonist AdipoRon induces apoptotic cell death and suppresses proliferation in human ovarian cancer cells.
Adiponectin Reverses the Proliferative Effects of Estradiol and IGF-1 in Human Epithelial Ovarian Cancer Cells by Downregulating the Expression of Their Receptors.
Expression of adiponectin and its receptors is altered in epithelial ovarian tumors and ascites-derived ovarian cancer cell lines.
Histotype-specific analysis of acid ceramidase expression in ovarian cancer.
Overweight
Adiponectin concentration in plasma is associated with muscle fiber size in healthy middle-aged men.
Reduced response to adiponectin and lower abundance of adiponectin receptor proteins in type 2 diabetic monocytes.
Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children.
Pancreatic Neoplasms
Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1? signaling.
Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis.
Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells.
Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice.
Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.
Papillomavirus Infections
Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
Parkinson Disease
Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease.
Periodontal Diseases
Endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis-induced inflammation in vitro.
Periodontitis
An Adiponectin Receptor Agonist Reduces Type 2 Diabetic Periodontitis.
Endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis-induced inflammation in vitro.
Pheochromocytoma
Adiponectin and adiponectin receptors in human pheochromocytoma.
Expression of adiponectin receptors 1 and 2 and the leptin receptor in human adrenal tumors.
Pneumonia
Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell Lines.
Polycystic Ovary Syndrome
A potential determinant role of adiponectin and receptors for the early embryo development in PCOS patients with obesity hinted by quantitative profiling.
Association between adiponectin receptor 1 gene polymorphism and insulin resistance in Chinese patients with polycystic ovary syndrome.
Association of single nucleotide polymorphisms in adiponectin and its receptor genes with polycystic ovary syndrome.
Oral Quercetin Supplementation Enhances Adiponectin Receptor Transcript Expression in Polycystic Ovary Syndrome Patients: A Randomized Placebo-Controlled Double-Blind Clinical Trial.
Upregulation of adiponectin receptor 1 and 2 mRNA and protein in adipose tissue and adipocytes in insulin-resistant women with polycystic ovary syndrome.
Prader-Willi Syndrome
Correlation of adiponectin receptor expression with cytokines and insulin sensitivity in growth hormone (GH)-treated children with Prader-Willi syndrome and in non-GH-treated obese children.
Pre-Eclampsia
Expressions of adiponectin receptors in placenta and their correlation with preeclampsia.
Increased placental mitochondrial fusion in gestational diabetes mellitus: an adaptive mechanism to optimize feto-placental metabolic homeostasis?
Prostatic Hyperplasia
Lack of adiponectin and adiponectin receptor 1 contributes to benign prostatic hyperplasia.
Prostatic Neoplasms
Acid ceramidase as a therapeutic target in metastatic prostate cancer.
Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
Acid Ceramidase Promotes Nuclear Export of PTEN through Sphingosine 1-Phosphate Mediated Akt Signaling.
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.
Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy.
Adiponectin inhibits VEGF-A in prostate cancer cells.
Adiponectin receptor activation inhibits prostate cancer xenograft growth.
Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production.
Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide.
Human acid ceramidase is overexpressed but not mutated in prostate cancer.
Increased acid ceramidase expression depends on upregulation of androgen-dependent deubiquitinases, USP2, in a human prostate cancer cell line, LNCaP.
Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2.
Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide.
Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells.
MiR-323 Inhibits Prostate Cancer Vascularization Through Adiponectin Receptor.
Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer.
Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk.
Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.
Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines.
The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts.
The Functional Effects of Acid Ceramidase Overexpression in Prostate Cancer Progression and Resistance to Chemotherapy.
Tumor expression of adiponectin receptor 2 and lethal prostate cancer.
[Role of adiponectin in prostate cancer: A preliminary study].
Pseudomonas Infections
Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis.
Psoriasis
Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice.
Pulmonary Disease, Chronic Obstructive
Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease.
Adiponectin oligomerization state and adiponectin receptors airway expression in chronic obstructive pulmonary disease.
Gene expression profile of human lung in a relatively early stage of COPD with emphysema.
Rectal Neoplasms
Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response.
Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer.
Reperfusion Injury
Electroacupuncture Attenuates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice Through Adiponectin Receptor 1-Mediated Phosphorylation of GSK-3?
Retinal Degeneration
ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrprd6 mouse.
Ceramidase expression facilitates membrane turnover and endocytosis of rhodopsin in photoreceptors.
Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration.
Rhabdoid Tumor
Acid ceramidase is a novel drug target for pediatric brain tumors.
Rhinitis, Allergic
The expression of adiponectin receptor is altered in mild and moderate/severe persistent allergic nasal mucosa.
Sandhoff Disease
A case of combined Farber and Sandhoff disease.
Scleroderma, Systemic
An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis.
Seizures
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study.
Hippocampal transcriptional and neurogenic changes evoked by combination yohimbine and imipramine treatment.
[A case report of childhood Farber's disease and literature review].
Sepsis
Obesity enhances sepsis-induced liver inflammation and injury in mice.
Small Cell Lung Carcinoma
Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.
Sphingolipidoses
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in cultured skin fibroblasts from sphingolipidosis patients.
Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in tissues from sphingolipidosis patients.
Squamous Cell Carcinoma of Head and Neck
Fas ligand gene transfer effectively induces apoptosis in head and neck cancer cells.
Role of Acid Ceramidase in Resistance to FasL: Therapeutic Approaches Based on Acid Ceramidase Inhibitors and FasL Gene Therapy.
Starvation
Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases.
Regulation of alkaline ceramidase activity by the c-Src-mediated pathway.
Status Epilepticus
Eyelid myoclonic status epilepticus: A rare phenotype in spinal muscular atrophy with progressive myoclonic epilepsy associated with ASAH1 gene mutation.
Stomach Neoplasms
Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2.
Adiponectin receptors are downregulated in human gastric cancer.
Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment.
Expression of AdipoR1 and AdipoR2 and Serum Level of Adiponectin in Gastric Cancer.
Genetic analysis of ADIPOQ variants and gastric cancer risk: a hospital-based case-control study in China.
Lack of any prognostic relationship between adiponectin receptor (Adipo R1/R2) expression for early/advanced stage gastric cancer.
RNA Sequencing of Early-Stage Gastric Adenocarcinoma Reveals Multiple Activated Pathways and Novel Long Non-Coding RNAs in Patient Tissue Samples.
Stomach Ulcer
AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice.
Stroke
Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death.
Relationship between adiponectin receptor 1 gene polymorphisms and ischemic stroke.
Synucleinopathies
Acid ceramidase inhibition ameliorates ?-synuclein accumulation upon loss of GBA1 function.
Thrombosis
Ceramidase critically affects GPVI-dependent platelet activation and thrombus formation.
Thyroid Neoplasms
Expression and Biologic Significance of Adiponectin Receptors in Papillary Thyroid Carcinoma.
Rapid screening of specific changes in mRNA in thyroid carcinomas by sequence specific-differential display: decreased expression of acid ceramidase mRNA in malignant and benign thyroid tumors.
Tuberculosis
Expression, purification, and characterization of a recombinant neutral ceramidase from Mycobacterium tuberculosis.
Molecular cloning, sequencing, and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from Mycobacterium tuberculosis.
Urinary Bladder Neoplasms
The role of adipocytokines and their receptors in bladder cancer: expression of adiponectin or leptin is an independent prognosticator.
Uterine Cervical Neoplasms
Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Vascular Diseases
Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease.
Vasculitis
Intragraft vasculitis and gene expression analysis: Association with acute rejection and prediction of mortality in long-term heart transplantation.
Virus Diseases
Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro.
Vision Disorders
Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.
Whooping Cough
Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression.
Hemolysis induced by Bacillus cereus sphingomyelinase.
Tumor necrosis factor-alpha inhibits the cardiac delayed rectifier K current via the asphingomyelin pathway.