Information on EC 3.5.1.21 - N-acetyl-beta-alanine deacetylase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.5.1.21
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RECOMMENDED NAME
GeneOntology No.
N-acetyl-beta-alanine deacetylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N-acetyl-beta-alanine + H2O = acetate + beta-alanine
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
beta-Alanine metabolism
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SYSTEMATIC NAME
IUBMB Comments
N-acetyl-beta-alanine amidohydrolase
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CAS REGISTRY NUMBER
COMMENTARY hide
37289-04-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
rat
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Manually annotated by BRENDA team
pig
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
N-acetyl-beta-alanine + H2O
beta-alanine + acetate
show the reaction diagram
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?
N-acetyl-taurine + H2O
taurine + acetate
show the reaction diagram
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reaction rate about 1/3 of that of acetyl-beta-alanine
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?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
AgNO3
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1 mM, 94% inhibition
CuSO4
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1 mM, 57% inhibition
ethylenediaminetetraacetate
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10 mM, 27% inhibition
HgCl2
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1 mM, 100% inhibition
monoiodoacetate
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1 mM, 73% inhibition
p-chloromercuribenzoate
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1 mM, 100% inhibition
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
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1 mM, activation 6%
L-cysteine
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1 mM, activation 33%
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
7.5
N-Acetyl-beta-alanine
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
33.5
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Sephadex G-200 eluate, 100fold purification
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.6
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50 - 70
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95% of enzyme activity remains after heating at 50°C for 2 min, 83% activity remains after 60°C heating for 2 min, 30% activity remains after heating at 70°C for 2 min
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partially
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