Reference on EC 3.5.1.2 - glutaminase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Heini, H.G.; Gebhardt, R.; Brecht, A.; Mecke, D.
Purification and characterization of rat liver glutaminase
Eur. J. Biochem.
162
541-546
1987
Rattus norvegicus
Kvamme, E.; Torgner, I.A.A.; Svenneby, G.
Glutaminase from mammalian tissues
Methods Enzymol.
113
241-256
1985
Rattus norvegicus, Sus scrofa
Holcenberg, J.S.
Glutaminase from Acinetobacter glutaminsificans
Methods Enzymol.
113
257-263
1985
Acinetobacter glutaminasificans
Haser, W.G.; Shaphiro, R.A.; Curthoys, N.P.
Comparison of the phosphate-dependent glutaminase obtained from rat brain and kidney
Biochem. J.
229
399-408
1985
Rattus norvegicus
Patel, M.; McGivan, J.D.
Partial purification and properties of rat liver glutaminase
Biochem. J.
220
583-590
1984
Rattus norvegicus
Snodgrass, P.J.; Lund, P.
Allosteric properties of phosphate-activated glutaminase of human liver mitochondria
Biochim. Biophys. Acta
798
21-27
1984
Homo sapiens
Ardawi, M.S.M.; Newsholme, E.A.
Intracellular localization and properties of phosphate-dependent glutaminase in rat mesenteric lymph nodes
Biochem. J.
217
289-296
1984
Rattus norvegicus
Morehouse, R.F.; Curthoys, N.P.
Properties of rat renal phosphate-dependent glutaminase coupled to Sepharose. Evidence that dimerization is essential for activation
Biochem. J.
193
709-716
1981
Rattus norvegicus
McGivan, J.D.; Lacey, J.H.; Joseph, S.K.
Localization and some properties of phosphate-dependent glutaminase in disrupted liver mitochondria
Biochem. J.
192
537-542
1980
Rattus norvegicus
Kvamme, E.; Olsen, B.E.
Evidence for two species of mammalian phosphate-activated glutaminase having different regulatory properties
FEBS Lett.
107
33-36
1979
Rattus norvegicus, Sus scrofa
Kovacevic, Z.; Breberina, M.; Pavlovic, M.; Bajin, K.
Molecular form and kinetic properties of phosphate-dependent glutaminase in the mitochondria isolated from the kidneys of normal and acidotic rats
Biochim. Biophys. Acta
567
216-224
1979
Rattus norvegicus
Oshima, M.; Yamamoto, T.; Soda, K.
Further characterization of glutaminase isoenzymes from Pseudomonas aeruginosa
Agric. Biol. Chem.
40
2251-2256
1976
Pseudomonas aeruginosa
-
Prusiner, S.; Davis, J.N.; Stadtman, E.R.
Regulation of glutaminase B in Escherichia coli. I. Purification, properties, and cold lability
J. Biol. Chem.
251
3447-3456
1976
Escherichia coli
Abe, T.; Takenaka, O.; Inada, Y.
Reinvestigation of the physicochemical and enzymic properties of L-glutaminase from Pseudomonas
Biochim. Biophys. Acta
358
113-116
1974
Pseudomonas sp.
Katsumata, H.; Katsumata, R.; Abe, T.; Takenaka, O.; Inada, Y.
Purification and physicochemical properties of L-glutaminase from Pseudomonas
Biochim. Biophys. Acta
289
405-409
1972
Pseudomonas sp.
Hartman, S.C.
Glutaminases and gamma-glutamyltransferases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
4
79-100
1971
Escherichia coli
-
Roberts, E.
Glutaminase
The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbck, K. , eds. )
4
285-300
1960
Canis lupus familiaris, Clostridium welchii, Sus scrofa
-
Moriguchi, M.; Sakai, K.; Tateyama, R.; Furuta, Y.; Wakayama, M.
Isolation and characterization of salt-tolerant glutaminases from marine Micrococcus luteus K-3
J. Ferment. Bioeng.
77
621-625
1994
Micrococcus luteus, Micrococcus luteus K-3
-
Campos, J.A.; Aledo, J.C.; del Castillo-Olivares, A.; del Valle, A.E.; de Castro, I.N.; Marquez, J.
Involvement of essential cysteine and histidine residues in the activity of isolated glutaminase from tumour cells
Biochim. Biophys. Acta
1429
275-283
1998
Mus musculus
Nelson, D.; Rumsey, W.L.; Erecinska, M.
Glutamine catabolism by heart muscle. Properties of phosphate-activated glutaminase
Biochem. J.
282
559-564
1992
Rattus norvegicus
Shapiro, R.A.; Farrell, L.; Srinivasan, M.; Curthoys, N.P.
Isolation, characterization, and in vitro expression of a cDNA that encodes the kidney isoenzyme of the mitochondrial glutaminase
J. Biol. Chem.
266
18792-18796
1991
Rattus norvegicus
Newcomb, R.; Pierce, A.R.; Kano, T.; Meng, W.; Bosque-Hamilton, P.; Taylor, L.; Curthoys, N.; Lo, E.H.
Characterization of mitochondrial glutaminase and amino acids at prolonged times after experimental focal cerebral ischemia
Brain Res.
813
103-111
1998
Rattus norvegicus
Swierczynski, J.; Bereznowski, Z.; Makarewicz, W.
Phosphate-dependent glutaminase of rat skeletal muscle. Some properties and possible role in glutamine metabolism
Biochim. Biophys. Acta
1157
55-62
1993
Homo sapiens, Rattus norvegicus
Nandakumar, R.; Wakayama, M.; Nagano, Y.; Kawamura, T.; Sakai, K.; Moriguchi, M.
Overexpression of salt-tolerant glutaminase from Micrococcus luteus K-3 in Escherichia coli and its purification
Protein Expr. Purif.
15
155-161
1999
Micrococcus luteus
Michalik, M.; Nelson, J.; Erecinska, M.
Glutamate production in islets of Langerhans: properties of phosphate-activated glutaminase
Metabolism
41
1319-1326
1992
Rattus norvegicus
Shenoy, V.; Roig, J.C.; Kubilis, P.; Neu, J.
Characterization of glutaminase in the developing rat small intestine
J. Nutr.
126
1121S-1130S
1996
Rattus norvegicus
Maity, P.; Chakraborty, S.; Bhattacharya, P.; Sarkar, R.
Isolation and purification of phosphate dependent glutaminase from sarcoma-180 tumor and its antineoplastic effects on murine model system
J. Exp. Clin. Cancer Res.
18
475-480
1999
Mus musculus
Segura, J.A.; Aledo, J.C.; Gomez-Biedma, S.; Nunez de Castro, I.
Tumor glutaminase purification
Protein Expr. Purif.
7
343-351
1995
Mus musculus
Chantawannakul, P.; Yoshimune, K.; Shirakihara, Y.; Shiratori, A.; Wakayama, M.; Moriguchi, M.
Crystallization and preliminary X-ray crystallographic studies of salt-tolerant glutaminase from Micrococcus luteus K-3
Acta Crystallogr. Sect. D
59
566-568
2003
Micrococcus luteus, Micrococcus luteus K-3
Sidel'nikova, L.I.; Evstigneeva, Z.G.; Solov'eva, N.A.; Shatilov, V.R.
Characterization of glutaminase from Triticale
Appl. Biochem. Microbiol.
37
569-573
2001
Triticale sp.
-
Huerta-Saquero, A.; Calderon-Flores, A.; Diaz-Villasenor, A.; Du Pont, G.; Duran, S.
Regulation of transcription and activity of Rhizobium etli glutaminase A
Biochim. Biophys. Acta
1673
201-207
2004
Rhizobium etli
Weingand-Ziade, A.; Gerber-Decombaz, C.; Affolter, M.
Functional characterization of a salt- and thermotolerant glutaminase from Lactobacillus rhamnosus
Enzyme Microb. Technol.
32
862-867
2003
Lacticaseibacillus rhamnosus
-
Olalla, L.; Aledo, J.C.; Bannenberg, G.; Marquez, J.
The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins
FEBS Lett.
488
116-122
2001
Homo sapiens (O14907), Homo sapiens
Klein, M.; Kaltwasser, H.; Jahns, T.
Isolation of a novel, phosphate-activated glutaminase from Bacillus pasteurii
FEMS Microbiol. Lett.
206
63-67
2002
Sporosarcina pasteurii
Castell, L.; Vance, C.; Abbott, R.; Marquez, J.; Eggleton, P.
Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity
J. Biol. Chem.
279
13305-13310
2004
Homo sapiens
Bauer, J.A.; Bennett, E.M.; Begley, T.P.; Ealick, S.E.
Three-dimensional structure of YaaE from Bacillus subtilis, a glutaminase implicated in pyridoxal-5'-phosphate biosynthesis
J. Biol. Chem.
279
2704-2711
2004
Bacillus subtilis
Kenny, J.; Bao, Y.; Hamm, B.; Taylor, L.; Toth, A.; Wagers, B.; Curthoys, N.P.
Bacterial expression, purification, and characterization of rat kidney-type mitochondrial glutaminase
Protein Expr. Purif.
31
140-148
2003
Rattus norvegicus
Soda, K.; Oshima, M.; Yamamoto, T.
Purification and properties of isozymes of glutaminase from Pseudomonas aeruginosa
Biochem. Biophys. Res. Commun.
46
1278-1284
1972
Pseudomonas aeruginosa, Pseudomonas aeruginosa (Q9I387)
Lebedeva, Z.I.; Berezov, T.T.
Molecular and catalytic properties of bacterial glutamin-(asparagin-)ase
Vestn. Akad. Med. Nauk SSSR
2
57-61
1995
Pseudomonas chlororaphis subsp. aurantiaca
-
Yoshimune, K.; Shirakihara, Y.; Shiratori, A.; Wakayama, M.; Chantawannakul, P.; Moriguchi, M.
Crystal structure of a major fragment of the salt-tolerant glutaminase from Micrococcus luteus K-3
Biochem. Biophys. Res. Commun.
346
1118-1124
2006
Micrococcus luteus, Micrococcus luteus K-3
Baglietto-Vargas, D.; Lopez-Tellez, J.F.; Moreno-Gonzalez, I.; Gutierrez, A.; Aledo, J.C.
Segregation of two glutaminase isoforms in islets of Langerhans
Biochem. J.
381
483-487
2004
Rattus norvegicus
Perez-Gomez, C.; Campos-Sandoval, J.A.; Alonso, F.J.; Segura, J.A.; Manzanares, E.; Ruiz-Sanchez, P.; Gonzalez, M.E.; Marquez, J.; Mates, J.M.
Co-expression of glutaminase K and L isoenzymes in human tumour cells
Biochem. J.
386
535-542
2005
Homo sapiens
Watford, M.; Wu, G.
Glutamine metabolism in uricotelic species: variation in skeletal muscle glutamine synthetase, glutaminase, glutamine levels and rates of protein synthesis
Comp. Biochem. Physiol. B
140B
607-614
2005
Gallus gallus, Columba livia, Sceloporus undulatus
-
Yoshimune, K.; Yamashita, R.; Masuo, N.; Wakayama, M.; Moriguchi, M.
Digestion by serine proteases enhances salt tolerance of glutaminase in the marine bacterium Micrococcus luteus K-3
Extremophiles
8
441-446
2004
Micrococcus luteus, Micrococcus luteus K-3
Sivakumar, K.; Sahu, M.K.; Manivel, P.R.; Kannan, L.
Optimum conditions for L-glutaminase production by actinomycete strain isolated from estuarine fish, Chanos chanos (Forskal, 1775)
Indian J. Exp. Biol.
44
256-258
2006
Streptomyces rimosus, Streptomyces rimosus LG-10
Masuo, N.; Yoshimune, K.; Ito, K.; Matsushima, K.; Koyama, Y.; Moriguchi, M.
Micrococcus luteus K-3-type glutaminase from Aspergillus oryzae RIB40 is salt-tolerant
J. Biosci. Bioeng.
100
576-578
2005
Aspergillus oryzae
Buschdorf, J.P.; Li Chew, L.; Zhang, B.; Cao, Q.; Liang, F.Y.; Liou, Y.C.; Zhou, Y.T.; Low, B.C.
Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels
J. Cell Sci.
119
3337-3350
2006
Homo sapiens (O94925), Homo sapiens
Romero-Gomez, M.; Ramos-Guerrero, R.; Grande, L.; de Teran, L.C.; Corpas, R.; Camacho, I.; Bautista, J.D.
Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy
J. Hepatol.
41
49-54
2004
Homo sapiens
Wakayama, M.; Yamagata, T.; Kamemura, A.; Bootim, N.; Yano, S.; Tachiki, T.; Yoshimune, K.; Moriguchi, M.
Characterization of salt-tolerant glutaminase from Stenotrophomonas maltophilia NYW-81 and its application in Japanese soy sauce fermentation
J. Ind. Microbiol. Biotechnol.
32
383-390
2005
Stenotrophomonas maltophilia, Stenotrophomonas maltophilia NYW-81
Masson, J.; Darmon, M.; Conjard, A.; Chuhma, N.; Ropert, N.; Thoby-Brisson, M.; Foutz, A.S.; Parrot, S.; Miller, G.M.; Jorisch, R.; Polan, J.; Hamon, M.; Hen, R.; Rayport, S.
Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth
J. Neurosci.
26
4660-4671
2006
Mus musculus
Romero-Gomez, M.
Role of phosphate-activated glutaminase in the pathogenesis of hepatic encephalopathy
Metab. Brain Dis.
20
319-325
2005
Homo sapiens
Marquez, J.; de la Oliva, A.R.; Mates, J.M.; Segura, J.A.; Alonso, F.J.
Glutaminase: a multifaceted protein not only involved in generating glutamate
Neurochem. Int.
48
465-471
2006
Homo sapiens, no activity in Gallus gallus, Rattus norvegicus
Masuo, N.; Ito, K.; Yoshimune, K.; Hoshino, M.; Matsushima, K.; Koyama, Y.; Moriguchi, M.
Molecular cloning, overexpression, and purification of Micrococcus luteus K-3-type glutaminase from Aspergillus oryzae RIB40
Protein Expr. Purif.
38
272-278
2004
Aspergillus oryzae (Q66V97), Aspergillus oryzae RIB 40 (Q66V97)
Fisher, R.S.
Co-localization of glutamic acid decarboxylase and phosphate-activated glutaminase in neurons of lateral reticular nucleus in feline thalamus
Neurochem. Res.
32
177-186
2007
Felis catus
Robinson, M.M.; McBryant, S.J.; Tsukamoto, T.; Rojas, C.; Ferraris, D.V.; Hamilton, S.K.; Hansen, J.C.; Curthoys, N.P.
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)
Biochem. J.
406
407-414
2007
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Montero, F.; Baglietto-Vargas, D.; Moreno-Gonzalez, I.; Lopez-Tellez, J.F.; Cuesta-Munoz, A.L.; Gutierrez, A.; Aledo, J.C.
Glutaminase activity is confined to the mantle of the islets of Langerhans
Biochimie
89
1366-1371
2007
Rattus norvegicus
Iyer, P.; Singhal, R.S.
Production of glutaminase (E.C.3.2.1.5) from Zygosaccharomyces rouxii: statistical optimization using response surface methodology
Biores. Technol.
99
4300-4307
2008
Zygosaccharomyces rouxii
Roy, S.; Ghosh, S.; Mallick, P.; Maity, P.
Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells-an in vitro study
Indian J. Exp. Biol.
46
22-26
2008
Escherichia coli
Campos-Sandoval, J.A.; Lopez de la Oliva, A.R.; Lobo, C.; Segura, J.A.; Mates, J.M.; Alonso, F.J.; Marquez, J.
Expression of functional human glutaminase in baculovirus system: affinity purification, kinetic and molecular characterization
Int. J. Biochem. Cell Biol.
39
765-773
2007
Homo sapiens
Yano, S.; Kamemura, A.; Yoshimune, K.; Moriguchi, M.; Yamamoto, S.; Tachiki, T.; Wakayama, M.
Analysis of essential amino acid residues for catalytic activity of glutaminase from Micrococcus luteus K-3
J. Biosci. Bioeng.
102
362-364
2006
Micrococcus luteus, Micrococcus luteus K-3
Erdmann, N.; Zhao, J.; Lopez, A.L.; Herek, S.; Curthoys, N.; Hexum, T.D.; Tsukamoto, T.; Ferraris, D.; Zheng, J.
Glutamate production by HIV-1 infected human macrophage is blocked by the inhibition of glutaminase
J. Neurochem.
102
539-549
2007
Homo sapiens
Holten, A.T.; Gundersen, V.
Glutamine as a precursor for transmitter glutamate, aspartate and GABA in the cerebellum: a role for phosphate-activated glutaminase
J. Neurochem.
104
1032-1042
2008
Rattus norvegicus
Tian, C.; Erdmann, N.; Zhao, J.; Cao, Z.; Peng, H.; Zheng, J.
HIV-infected macrophages mediate neuronal apoptosis through mitochondrial glutaminase
J. Neurochem.
105
994-1005
2008
Homo sapiens
Bak, L.K.; Zieminska, E.; Waagepetersen, H.S.; Schousboe, A.; Albrecht, J.
Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix
Neurochem. Res.
33
273-278
2008
Rattus norvegicus
Tambasco-Studart, M.; Tews, I.; Amrhein, N.; Fitzpatrick, T.B.
Functional analysis of PDX2 from Arabidopsis, a glutaminase involved in vitamin B6 biosynthesis
Plant Physiol.
144
915-925
2007
Arabidopsis thaliana
Romero-Gomez, M.; Jover, M.; Diaz-Gomez, D.; de Teran, L.C.; Rodrigo, R.; Camacho, I.; Echevarria, M.; Felipo, V.; Bautista, J.D.
Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis
World J. Gastroenterol.
12
2406-2411
2006
Rattus norvegicus
Kaufmann, Y.; Todorova, V.K.; Luo, S.; Klimberg, V.S.
Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model
Nutr. Cancer
60
518-525
2008
Rattus norvegicus (P13264)
Brown, G.; Singer, A.; Proudfoot, M.; Skarina, T.; Kim, Y.; Chang, C.; Dementieva, I.; Kuznetsova, E.; Gonzalez, C.F.; Joachimiak, A.; Savchenko, A.; Yakunin, A.F.
Functional and structural characterization of four glutaminases from Escherichia coli and Bacillus subtilis
Biochemistry
47
5724-5735
2008
Bacillus subtilis (O07637), Bacillus subtilis (O31465), Bacillus subtilis, Escherichia coli (P0A6W0), Escherichia coli (P77454), Escherichia coli, Bacillus subtilis 168 (O07637), Bacillus subtilis 168 (O31465), Escherichia coli W3110 / ATCC 27325 (P0A6W0), Escherichia coli W3110 / ATCC 27325 (P77454)
Zhou, J.X.; Zhou, J.; Yang, H.M.; Chen, M.; Huang, F.
Characterization of two glutaminases from the filamentous cyanobacterium Anabaena sp. PCC 7120
FEMS Microbiol. Lett.
289
241-249
2008
Anabaena sp. (Q8YMZ9), Anabaena sp. (Q8YSZ5)
Erdmann, N.; Tian, C.; Huang, Y.; Zhao, J.; Herek, S.; Curthoys, N.; Zheng, J.
In vitro glutaminase regulation and mechanisms of glutamate generation in HIV-1-infected macrophage
J. Neurochem.
109
551-561
2009
Homo sapiens
Pais, T.F.; Figueiredo, C.; Peixoto, R.; Braz, M.H.; Chatterjee, S.
Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway
J. Neuroinflammation
5
43
2008
Mus sp.
Gao, P.; Tchernyshyov, I.; Chang, T.C.; Lee, Y.S.; Kita, K.; Ochi, T.; Zeller, K.I.; De Marzo, A.M.; Van Eyk, J.E.; Mendell, J.T.; Dang, C.V.
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
Nature
458
762-765
2009
Homo sapiens
Zhou, J.; Zhou, J.; Yang, H.; Yan, C.; Huang, F.
Characterization of a sodium-regulated glutaminase from cyanobacterium Synechocystis sp. PCC 6803
Sci. China C Life Sci.
51
1066-1075
2008
Synechocystis sp. PCC 6803 (P73903)
Jeon, J.; Lee, H.; So, J.
Glutaminase activity of Lactobacillus reuteri KCTC3594 and expression of the activity in other Lactobacillus spp. by introduction of the glutaminase gene
Afr. J. Microbiol. Res.
3
605-609
2009
Limosilactobacillus reuteri
-
Thongsanit, J.; Tanikawa, M.; Yano, S.; Tachiki, T.; Wakayama, M.
Identification of glutaminase-producing lactic acid bacteria isolated from Nham, a traditional Thai fermented food and characterisation of glutaminase activity of isolated Weissella cibaria
Ann. Microbiol.
59
715-720
2009
Weissella cibaria
Jeon, J.M.; Lee, H.I.; Han, S.H.; Chang, C.S.; So, J.S.
Partial purification and characterization of glutaminase from Lactobacillus reuteri KCTC3594
Appl. Biochem. Biotechnol.
162
146-154
2010
Limosilactobacillus reuteri
Jaisson, S.; Veiga-da-Cunha, M.; Van Schaftingen, E.
Molecular identification of omega-amidase, the enzyme that is functionally coupled with glutamine transaminases, as the putative tumor suppressor Nit2
Biochimie
91
1066-1071
2009
Mus musculus
Yoshimune, K.; Shirakihara, Y.; Wakayama, M.; Yumoto, I.
Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris
FEBS J.
277
738-748
2010
Micrococcus luteus (Q4U1A6)
Roberg, B.A.; Torgner, I.A.; Kvamme, E.
Kinetics of a novel isoform of phosphate activated glutaminase (PAG) in SH-SY5Y neuroblastoma cells
Neurochem. Res.
35
875-880
2010
Homo sapiens
Ali, T.; Ali, N.; Mohamed, L.
Glutamine amidohydrolase from Penicillium politans NRC 510
Pol. J. Food Nutr. Sci.
59
211-217
2009
Penicillium palitans
-
Hu, W.; Zhang, C.; Wu, R.; Sun, Y.; Levine, A.; Feng, Z.
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
Proc. Natl. Acad. Sci. USA
107
7455-7460
2010
Homo sapiens
Suzuki, S.; Tanaka, T.; Poyurovsky, M.V.; Nagano, H.; Mayama, T.; Ohkubo, S.; Lokshin, M.; Hosokawa, H.; Nakayama, T.; Suzuki, Y.; Sugano, S.; Sato, E.; Nagao, T.; Yokote, K.; Tatsuno, I.; Prives, C.
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
Proc. Natl. Acad. Sci. USA
107
7461-7466
2010
Homo sapiens
Kita, K.; Sato, M.; Suzuki, T.; Ochi, T.
Structure-effect relationship in the down-regulation of glutaminase in cultured human cells by phenylarsenic compounds
Toxicology
258
157-163
2009
Homo sapiens
Prokop, M.; Czarnecka, J.; Milewska, M.
Ngamma-alkyl derivatives of L-glutamine as inhibitors of glutamine-utilizing enzymes
Z. Naturforsch. C
64
631-636
2009
Escherichia coli
Kumar, L.; Singh, B.; Adhikari, D.K.; Mukherjee, J.; Ghosh, D.
A temperature and salt-tolerant L-glutaminase from Gangotri region of uttarakhand himalaya: enzyme purification and characterization
Appl. Biochem. Biotechnol.
166
1723-1735
2012
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) LKG-01
DeLaBarre, B.; Gross, S.; Fang, C.; Gao, Y.; Jha, A.; Jiang, F.; Song J, J.; Wei, W.; Hurov, J.B.
Full-length human glutaminase in complex with an allosteric inhibitor
Biochemistry
50
10764-10770
2011
Homo sapiens, Homo sapiens (O94925)
List, F.; Bocola, M.; Haeger, M.C.; Sterner, R.
Constitutively active glutaminase variants provide insights into the activation mechanism of anthranilate synthase
Biochemistry
51
2812-2818
2012
Thermotoga maritima
Ito, K.; Umitsuki, G.; Oguma, T.; Koyama, Y.
Salt-tolerant and thermostable glutaminases of Cryptococcus species form a new glutaminase family
Biosci. Biotechnol. Biochem.
75
1317-1324
2011
Naganishia albida, Papiliotrema flavescens, Naganishia albida ATCC 20293, Papiliotrema flavescens NISL 3771
Hashizume, R.; Maki, Y.; Mizutani, K.; Takahashi, N.; Matsubara, H.; Sugita, A.; Sato, K.; Yamaguchi, S.; Mikami, B.
Crystal structures of protein glutaminase and its pro forms converted into enzyme-substrate complex
J. Biol. Chem.
286
38691-38702
2011
Chryseobacterium proteolyticum
Cassago, A.; Ferreira, A.P.; Ferreira, I.M.; Fornezari, C.; Gomes, E.R.; Greene, K.S.; Pereira, H.M.; Garratt, R.C.; Dias, S.M.; Ambrosio, A.L.
Mitochondrial localization and structure-based phosphate activation mechanism of glutaminase C with implications for cancer metabolism
Proc. Natl. Acad. Sci. USA
109
1092-1097
2012
Homo sapiens
Thangavelu, K.; Pan, C.Q.; Karlberg, T.; Balaji, G.; Uttamchandani, M.; Suresh, V.; Schueler, H.; Low, B.C.; Sivaraman, J.
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism
Proc. Natl. Acad. Sci. USA
109
7705-7710
2012
Homo sapiens
Sinsuwan, S.; Yongsawatdigul, J.; Chumseng, S.; Yamabhai, M.
Efficient expression and purification of recombinant glutaminase from Bacillus licheniformis (GlsA) in Escherichia coli
Protein Expr. Purif.
83
52-58
2012
Bacillus licheniformis (Q65NY1), Bacillus licheniformis, Bacillus licheniformis DSM 13 (Q65NY1)
Singh, P.; Banik, R.M.
Biochemical characterization and antitumor study of L-glutaminase from Bacillus cereus MTCC 1305
Appl. Biochem. Biotechnol.
171
522-531
2013
Bacillus cereus, Bacillus cereus MTCC 1305
Ito, K.; Hanya, Y.; Koyama, Y.
Purification and characterization of a glutaminase enzyme accounting for the majority of glutaminase activity in Aspergillus sojae under solid-state culture
Appl. Microbiol. Biotechnol.
97
8581-8590
2013
Aspergillus sojae
Karahan, M.; Karakus, E.; Buelbuel, D.; Ataci, N.
Immobilization of glutaminase enzyme from Hypocria jecorina on polyacrylic acid: preparation and biochemical characterization
Artif. Cells Nanomed. Biotechnol.
42
262-267
2014
Trichoderma reesei
Pu, H.; Wang, Q.; Zhu, F.; Cao, X.; Xin, Y.; Luo, L.; Yin, Z.
Cloning, expression of glutaminase from Pseudomonas nitroreducens and application to theanine synthesis
Biocatal. Biotransform.
31
1-7
2013
Pseudomonas nitroreducens (K7NB71), Pseudomonas nitroreducens DSM 14399 (K7NB71)
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Thomas, A.G.; Rojas, C.; Tanega, C.; Shen, M.; Simeonov, A.; Boxer, M.B.; Auld, D.S.; Ferraris, D.V.; Tsukamoto, T.; Slusher, B.S.
Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors
Biochem. Biophys. Res. Commun.
438
243-248
2013
Mus musculus
Pandian, S.; Deepak, V.; Sivasubramaniam, S.; Nellaiah, H.; Sundar, K.
Optimization and purification of anticancer enzyme L-glutaminase from Alcaligenes faecalis KLU102
Biologia
69
1644-1651
2015
Alcaligenes faecalis, Alcaligenes faecalis KLU102
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Ye, M.; Liu, X.; Zhao, L.
Production of a novel salt-tolerant L-glutaminase from Bacillus amyloliquefaciens using agro-industrial residues and its application in chinese soy sauce fermentation
Biotechnology
12
25-35
2013
Bacillus amyloliquefaciens, Bacillus amyloliquefaciens Y-9
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Shukla, K.; Ferraris, D.V.; Thomas, A.G.; Stathis, M.; Duvall, B.; Delahanty, G.; Alt, J.; Rais, R.; Rojas, C.; Gao, P.; Xiang, Y.; Dang, C.V.; Slusher, B.S.; Tsukamoto, T.
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) analogs as glutaminase inhibitors
J. Med. Chem.
55
10551-10563
2012
Homo sapiens (O94925), Homo sapiens
Katt, W.P.; Ramachandran, S.; Erickson, J.W.; Cerione, R.A.
Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation
Mol. Cancer Ther.
11
1269-1278
2012
Mus musculus
Lee, Y.Z.; Yang, C.W.; Chang, H.Y.; Hsu, H.Y.; Chen, I.S.; Chang, H.S.; Lee, C.H.; Lee, J.C.; Kumar, C.R.; Qiu, Y.Q.; Chao, Y.S.; Lee, S.J.
Discovery of selective inhibitors of glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells
Oncotarget
5
6087-6101
2014
Homo sapiens
Ampuero, J.; Ranchal, I.; Nunez, D.; Diaz-Herrero, M.d.e.l..M.; Maraver, M.; del Campo, J.A.; Rojas, A.; Camacho, I.; Figueruela, B.; Bautista, J.D.; Romero-Gomez, M.
Metformin inhibits glutaminase activity and protects against hepatic encephalopathy
PLoS ONE
7
e49279
2012
Homo sapiens
Thangavelu, K.; Chong, Q.Y.; Low, B.C.; Sivaraman, J.
Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA)
Sci. Rep.
4
3827
2014
Homo sapiens (O94925), Homo sapiens
Dutta, S.; Ghosh, S.; Pramanik, S.
L-asparaginase and L-glutaminase from Aspergillus fumigatus WL002 Production and some physicochemical properties
Appl. Biochem. Microbiol.
51
425-431
2015
Aspergillus fumigatus, Aspergillus fumigatus WL002
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Bazaraa, W.; Alian, A.; El-Shimi, N.; Mohamed, R.
Purification and characterization of extracellular glutaminase from Aspergillus oryzae NRRL 32567
Biocatal. Agricult. Biotechnol.
6
76-81
2016
Aspergillus oryzae, Aspergillus oryzae NRRL 32567
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Desai, S.; Chopra, S.; Hungund, B.
Production, purification and characterization of L-glutaminase from Streptomyces sp. isolated from soil
J. Appl. Pharm. Sci.
6
100-105
2016
Streptomyces sp.
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Abu-Tahon, M.A.; Isaac, G.S.
Purification, characterization and anticancer efficiency of L-glutaminase from Aspergillus flavus
J. Gen. Appl. Microbiol.
65
284-292
2019
Aspergillus flavus
Xie, C.; Jin, J.; Bao, X.; Zhan, W.H.; Han, T.Y.; Gan, M.; Zhang, C.; Wang, J.
Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer
Oncotarget
7
610-621
2016
Homo sapiens
Maggi, M.; Chiarelli, L.R.; Valentini, G.; Scotti, C.
Engineering of Helicobacter pylori L-asparaginase characterization of two functionally distinct groups of mutants
PLoS ONE
10
e0117025
2015
Helicobacter pylori (A0A2X5A091), Helicobacter pylori, Helicobacter pylori ATCC 43504 (A0A2X5A091)
More, S.; Swamy, R.; Mohan, N.; Navyashree, M.; Janardhan, B.; Niyonzima, F.
Purification and characterization of anti-cancer L-glutaminase of Bacillus cereus strain LC13
Proc. Natl. Acad. Sci. India: Sect. B Biol. Sci.
88
695-705
2018
Bacillus cereus, Bacillus cereus LC13
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Shah, L.; Nadeem, M.; Khan, J.; Zeyadi, M.; Zamzami, M.; Mohammed, K.
Recombinant L-glutaminase obtained from Geobacillus thermodenitrificans DSM-465 characterization and in silico elucidation of conserved structural domains
RSC Adv.
9
4258-4267
2019
Geobacillus thermodenitrificans (A4IPX2), Geobacillus thermodenitrificans NG80-2 (A4IPX2)
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