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N-acetylaspartic acid + H2O
L-asparatate + acetate
acetyl-DL-alanine + H2O
acetate + DL-alanine
-
-
-
-
?
acetyl-DL-methionine + H2O
acetate + methionine
-
-
-
-
?
acetyl-L-glutamate + H2O
acetate + glutamate
-
-
-
-
?
acetyl-L-leucine + H2O
acetate + leucine
-
-
-
-
?
chloroacetyl-DL-alanine + H2O
chloroacetate + DL-alanine
-
-
-
-
?
chloroacetyl-DL-norleucine + H2O
chloroacetate + DL-norleucine
-
-
-
-
?
chloroacetyl-L-aspartate + H2O
chloroacetate + L-aspartate
-
-
-
-
?
chloroacetyl-L-leucine + H2O
chloroacetate + L-leucine
-
-
-
-
?
N-acetyl-L-aspartate + H2O
aspartate + acetate
-
deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease
-
-
?
N-acetyl-L-aspartate + H2O
L-aspartate + acetic acid
-
-
-
-
?
N-acetyl-L-aspartic acid + H2O
acetate + aspartic acid
-
-
-
-
?
N-acetylaspartic acid + H2O
aspartate + acetate
N-acetylaspartic acid + H2O
L-asparatate + acetate
N-acyl L-aspartic acid + H2O
acetate + L-aspartate
-
-
-
-
?
N-formyl aspartic acid + H2O
formate + aspartate
-
-
-
-
?
additional information
?
-
-
N-methyl aspartic acid, N-carbamoyl aspartic acid and N-glycyl aspartic acids are no substrates
-
-
?
N-acetylaspartic acid + H2O
L-asparatate + acetate
-
-
-
?
N-acetylaspartic acid + H2O
L-asparatate + acetate
the enzyme is involved in negative regulation of brain-derived neurotrophic factor, BDNF, and timing of postnatal oligodendrogenesis, overview
-
-
?
N-acetylaspartic acid + H2O
aspartate + acetate
-
-
-
-
?
N-acetylaspartic acid + H2O
aspartate + acetate
-
enzyme mutations cause the Canavan disease and type 2 diabetes
-
-
?
N-acetylaspartic acid + H2O
L-asparatate + acetate
-
-
-
-
?
N-acetylaspartic acid + H2O
L-asparatate + acetate
-
enzyme mutations cause the Canavan disease
-
-
?
N-acetylaspartic acid + H2O
L-asparatate + acetate
-
restoration of deficient enzyme activity by enzyme expression in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease, which is caused by elevated levels of N-acetylaspartic acid, NAA, neuronal expression of ASPA can compensate for NAA-mediated neuronal hyperexcitation, but not for oligodebdrocyte dysfunciton, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N-acetylaspartic acid + H2O
L-asparatate + acetate
the enzyme is involved in negative regulation of brain-derived neurotrophic factor, BDNF, and timing of postnatal oligodendrogenesis, overview
-
-
?
N-acetyl-L-aspartate + H2O
aspartate + acetate
-
deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease
-
-
?
N-acetyl-L-aspartic acid + H2O
acetate + aspartic acid
-
-
-
-
?
N-acetylaspartic acid + H2O
aspartate + acetate
N-acetylaspartic acid + H2O
L-asparatate + acetate
N-acetylaspartic acid + H2O
aspartate + acetate
-
-
-
-
?
N-acetylaspartic acid + H2O
aspartate + acetate
-
enzyme mutations cause the Canavan disease and type 2 diabetes
-
-
?
N-acetylaspartic acid + H2O
L-asparatate + acetate
-
-
-
-
?
N-acetylaspartic acid + H2O
L-asparatate + acetate
-
enzyme mutations cause the Canavan disease
-
-
?
N-acetylaspartic acid + H2O
L-asparatate + acetate
-
restoration of deficient enzyme activity by enzyme expression in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease, which is caused by elevated levels of N-acetylaspartic acid, NAA, neuronal expression of ASPA can compensate for NAA-mediated neuronal hyperexcitation, but not for oligodebdrocyte dysfunciton, overview
-
-
?
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D'Adamo, A.F.; Wertman, E.; Foster, F.; Schneider, H.
A radiochemical assay for N-acetyl-L-aspartate amidohydrolase (EC 3.5.1.15) and its occurrence in the tissues of the chicken
Life Sci.
23
791-796
1978
Columba sp., Gallus sp., no activity in Cavia porcellus, Rattus norvegicus
brenda
Endo, Y.
Deacetylation and deformylation of N-acyl amino acids by kidney acylases
FEBS Lett.
95
281-283
1978
Cavia porcellus, Rattus norvegicus, Rattus norvegicus Wistar
brenda
D'Adamo, A.F.; Peisach, J.; Manner, G.; Weiler, C.T.
N-Acetyl-aspartate amidohydrolase: Purification and properties
J. Neurochem.
28
739-744
1977
Gallus sp., Rattus norvegicus, Sus scrofa
brenda
Goldstein, F.B.
Amidohydrolases of brain; enzymatic hydrolysis of N-acetyl-L-aspartate and other N-acyl-L-amino acids
J. Neurochem.
26
45-49
1976
Bos taurus, Columba sp., Felis catus, Macaca iris, Macaca mulatta, Mesocricetus auratus, Mus musculus, no activity in Cavia porcellus, Oryctolagus cuniculus, Rattus norvegicus, Rattus norvegicus Sprague Dawley, Sus scrofa
brenda
D'Adamo, A.F.; Smith, J.C.; Weiler, C.
The occurrence of N-acetylaspartate amidohydrolase (aminoacylase II) in the developing rat
J. Neurochem.
20
1275-1278
1973
Rattus norvegicus, Rattus norvegicus Sprague Dawley, Sus scrofa
brenda
Baslow, M.H.; Suckow, R.F.; Sapirstein, V.; Hungund, B.L.
Expression of aspartoacylase activity in cultured rat macroglial cells is limited to oligodendrocytes
J. Mol. Neurosci.
13
47-53
1999
Carassius auratus, Homo sapiens, Rattus norvegicus
brenda
Barash, V.; Flhor, D.; Morag, B.; Boneh, A.; Elpeleg, O.N.; Gilon, C.
A radiometric assay for aspartoacylase activity in human fibroblasts: application for the diagnosis of canavan's disease
Clin. Chim. Acta
201
175-182
1991
Homo sapiens, Rattus norvegicus
brenda
Hershfield, J.R.; Madhavarao, C.N.; Moffett, J.R.; Benjamins, J.A.; Garbern, J.Y.; Namboodiri, A.
Aspartoacylase is a regulated nuclear-cytoplasmic enzyme
FASEB J.
20
2139-2141
2006
Rattus norvegicus
brenda
Madhavarao, C.N.; Moffett, J.R.; Moore, R.A.; Viola, R.E.; Namboodiri, M.A.; Jacobowitz, D.M.
Immunohistochemical localization of aspartoacylase in the rat central nervous system
J. Comp. Neurol.
472
318-329
2004
Rattus norvegicus
brenda
Francis, J.S.; Olariu, A.; McPhee, S.W.; Leone, P.
Novel role for aspartoacylase in regulation of BDNF and timing of postnatal oligodendrogenesis
J. Neurosci. Res.
84
151-169
2006
Rattus norvegicus (Q9R1T5)
brenda
Klugmann, M.; Leichtlein, C.B.; Symes, C.W.; Serikawa, T.; Young, D.; During, M.J.
Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease
Mol. Ther.
11
745-753
2005
Homo sapiens, Rattus norvegicus
brenda
Surendran, S.
Upregulation of N-acetylaspartic acid alters inflammation, transcription and contractile associated protein levels in the stomach and smooth muscle contractility
Mol. Biol. Rep.
345
973-975
2007
Rattus norvegicus
brenda
Bitto, E.; Bingman, C.A.; Wesenberg, G.E.; McCoy, J.G.; Phillips, G.N.
Structure of aspartoacylase, the brain enzyme impaired in Canavan disease
Proc. Natl. Acad. Sci. USA
104
456-461
2007
Rattus norvegicus, Homo sapiens (P45381), Homo sapiens
brenda
Hanaya, R.; Kiura, Y.; Kurisu, K.; Sakai, N.; Serikawa, T.; Sasa, M.
N-acetyl-L-aspartate activates hippocampal CA3 neurons in rodent slice preparations
Brain Res. Bull.
75
663-667
2008
Rattus norvegicus
brenda
Surendran, S.
Upregulation of N-acetylaspartic acid alters inflammation, transcription and contractile associated protein levels in the stomach and smooth muscle contractility
Mol. Biol. Rep.
36
201-206
2009
Rattus norvegicus
brenda