Reference on EC 3.5.1.14 - N-acyl-aliphatic-L-amino acid amidohydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Moriguchi, M.; Sakai, K.; Katsuno, Y.; Maki, T.; Wakayama, M.
Purification and characterization of novel N-acyl-D-aspartate amidohydrolase from Alcaligenes xylosoxydans subsp. xylosoxydans A-6
Biosci. Biotechnol. Biochem.
57
1145-1148
1993
Alcaligenes sp.
Birnbaum, S.M.; Levintow, L.; Kingsley, R.B.; Greenstein, J.P.
Specificity of amino acid acylases
J. Biol. Chem.
194
455-470
1952
Sus scrofa
Fones, W.S.; Lee, M.
Hydrolysis of N-acyl derivatives of alanine and phenylalanine by acylase I and carboxypeptidase
J. Biol. Chem.
201
847-856
1953
Sus scrofa
Park, R.W.; Fox, S.W.
An acylase system related to the utilization of benzoylamino acids by Lactobacillus arabinosus
J. Biol. Chem.
235
3193-3197
1960
Streptomyces sp., Lactiplantibacillus plantarum, Sus scrofa
Matsumoto, J.; Nagai, S.
Amidohydrolases for N-short and long chain fatty acyl-L-amino acids from Mycobacteria
J. Biochem.
72
269-279
1972
Mycobacterium sp.
Koerdel, W.; Schneider, F.
Chemical investigations on pig kidney aminoacylase
Biochim. Biophys. Acta
445
446-457
1976
Sus scrofa
Gentzen, I.; Lffler, H.G.; Schneider, F.
Aminoacylase from Aspergillus oryzae. Comparison with the pig kidney enzyme
Z. Naturforsch. C
35
544-550
1980
Aspergillus oryzae, Sus scrofa
Sugie, M.; Suzuki, H.
Optical resolution of DL-amino acids with D-Aminoacylase of Streptomyces
Agric. Biol. Chem.
44
1089-1095
1980
Streptomyces sp., no activity in Streptomyces olivaceus, no activity in Streptomyces olivaceus IFO 12805
-
Szajani, B.; Ivony, K.; Boross, L.
Comparative studies on soluble and immobilized pig kidney aminoacylase
J. Appl. Biochem.
2
72-80
1980
Aspergillus oryzae, Sus scrofa
-
Gade, W.; Brown, J.L.
Purification, characterization and possible function of alpha-N-acylamino acid hydrolase from bovine liver
Biochim. Biophys. Acta
662
86-93
1981
Bos taurus, Sus scrofa
Gilles, I.; Loeffler, H.G.; Schneider, F.
Co2+-substituted acylamino acid amido hydrolase from Aspergillus oryzae
Z. Naturforsch. C
36
751-754
1981
Aspergillus oryzae
-
Kumpe, E.; Lffler, H.G.; Schneider, F.
Studies on the Zn2+/Co2+ exchange with acylamino acid amidohydrolase from pig kidney
Z. Naturforsch. C
36
951-955
1981
Sus scrofa
Cho, H.Y.; Tanizawa, K.; Tanaka, H.; Soda, K.
Thermostable aminoacylase from Bacillus thermoglucosidius: Purification and characterization
Agric. Biol. Chem.
51
2793-2800
1987
Aspergillus oryzae, Bacillus sp. (in: Bacteria), Sus scrofa
-
Henseling, J.; Roehm, K.H.
Unusual solvent isotope effects on the aminoacylase-catalyzed hydrolysis of acetylamino acids
FEBS Lett.
219
27-30
1987
Sus scrofa
Sakanyan, V.; Desmarez, L.; Legrain, C.; Charlier, D.; Mett, I.; Kochikyan, A.; Savchenko, A.; Boyen, A.; Falmagne, P.; Pierard, A.; Glansdorff, N.
Gene cloning, sequence analysis, purification, and characterization of an thermostable aminoacylase from Bacillus stearothermophilus
Appl. Environ. Microbiol.
59
3878-3888
1993
Aspergillus oryzae, Bacillus sp. (in: Bacteria), Homo sapiens, Sus scrofa
Yang, Y.B.; Hu, H.L.; Chang, M.C.; Li, H.; Tsai, Y.C.
Purification and characterization of L-aminoacylase from Alcaligenes denitrificans DA181
Biosci. Biotechnol. Biochem.
58
204-205
1994
Alcaligenes sp., Aspergillus oryzae, Bacillus sp. (in: Bacteria), Cercidium texanum, Sus scrofa, Aspergillus oryzae No.9
Palm, G.J.; Roehm, K.H.
Aminoacylase I from porcine kidney: Identification and characterization of two major protein domains
J. Protein Chem.
14
233-240
1995
Homo sapiens, Sus scrofa
Yang, Y.; Wang, H.R.; Zhou, H.M.
Kinetics of inhibition of aminoacylase activity by dithiothreitol or 2-mercaptoethanol
Int. J. Pept. Protein Res.
48
532-538
1996
Sus scrofa
Giardina, T.; Biagini, A.; Dalle Ore, F.; Ferre, E.; Reynier, M.; Puigserver, A.
The hog intestinal mucosa acylase I: Subcellular localization, isolation, kinetic studies and biological function
Biochimie
79
265-273
1997
Bos taurus, Sus scrofa
Uttamsingh, V.; Keller, D.A.; Anders, M.W.
Acylase I-catalyzed deacetylatin of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines
Chem. Res. Toxicol.
11
801-809
1998
Homo sapiens, Rattus norvegicus, Sus scrofa
Wakayama, M.; Shiiba, E.; Sakai, K.; Moriguchi, M.
Purification and characterization of L-aminoacylase from Pseudomonas maltophila B1
J. Ferment. Bioeng.
85
278-282
1998
Aspergillus oryzae, Bacillus sp. (in: Bacteria), Stenotrophomonas maltophilia, Sus scrofa
-
Wang, H.J.; Bai, J.H.; Liu, D.S.; Zhang, T.; Zhou, H.M.
Preparation and properties of immobilized pig kidney aminoacylase and optical resolution of N-acyl-DL-alanine
Appl. Biochem. Biotechnol.
76
183-191
1999
Aspergillus oryzae, Sus scrofa
Tamura, T.; Oki, Y.; Yoshida, A.; Kuriyama, T.; Kawakami, H.; Inoue, H.; Inagaki, K.; Tanaka, H.
Noncompetitive, reversible inhibition of aminoacylase-1 by a series of L-alpha-hydroxyl and L-alpha-fluoro fatty acids: Ligand specificity of Aspergillus oryzae and porcine kindney enzymes
Arch. Biochem. Biophys.
379
261-266
2000
Aspergillus oryzae, Sus scrofa
Liaw, S.H.; Chen, S.J.; Ko, T.P.; Hsu, C.S.; Chen, C.J.; Wang, A.H.; Tsai, Y.C.
Crystal structure of D-aminoacylase from Alcaligenes faecalis DA1. A novel subset of amidohydrolases and insights into the enzyme mechanism
J. Biol. Chem.
278
4957-4962
2003
Alcaligenes faecalis
Hsu, C.S.; Chen, S.J.; Tsai, Y.C.; Lin, T.W.; Liaw, S.H.; Wang, A.H.
Crystallization and preliminary crystallographic analysis of a D-aminoacylase from Alcaligenes faecalis DA1
Acta Crystallogr. Sect. D
58
1482-1483
2002
Alcaligenes faecalis
German, A.B.; Neklyudov, A.D.
Isolation and characterization of immobilized aminoacylase from Streptoverticillium olivoreticuli
Appl. Biochem. Microbiol.
37
55-58
2001
Streptomyces olivoreticuli
-
Leuchtenberger, W.; Huthmacher, K.; Drauz, K.
Biotechnological production of amino acids and derivatives: current status and prospects
Appl. Microbiol. Biotechnol.
69
1-8
2005
Aspergillus oryzae
Curley, P.; van der Does, C.; Driessen, A.J.; Kok, J.; van Sinderen, D.
Purification and characterisation of a lactococcal aminoacylase
Arch. Microbiol.
179
402-408
2003
Lactococcus lactis, Lactococcus lactis MG1363
D'Ambrosio, C.; Talamo, F.; Vitale, R.M.; Amodeo, P.; Tell, G.; Ferrara, L.; Scaloni, A.
Probing the dimeric structure of porcine aminoacylase 1 by mass spectrometric and modeling procedures
Biochemistry
42
4430-4443
2003
Sus scrofa (P37111), Sus scrofa
Durand, A.; Giardina, T.; Villard, C.; Roussel, A.; Puigserver, A.; Perrier, J.
Rat kidney acylase I: further characterization and mutation studies on the involvement of Glu 147 in the catalytic process
Biochimie
85
953-962
2003
Rattus norvegicus
Natsch, A.; Gfeller, H.; Gygax, P.; Schmid, J.; Acuna, G.
A specific bacterial aminoacylase cleaves odorant precursors secreted in the human axilla
J. Biol. Chem.
278
5718-5727
2003
Corynebacterium striatum, Corynebacterium striatum AX20
Rosenberg, S.H.; Spina, K.P.; Woods, K.W.; Polakowski, J.; Martin, D.L.
Studies directed toward the design of orally active renin inhibitors. 1.Somer factors influencing the absorbtion of small peptides
J. Med. Chem.
36
449-459
1993
Aspergillus niger
Honda, G.; Matsuda, A.; Zushi, M.; Yamamoto, S.; Komatsu, K.
Heterologous protein production in Acremonium chrysogenum: expression of bacterial cephalosporin C acylase and human thrombomodulin genes
Biosci. Biotechnol. Biochem.
61
948-955
1997
Pseudomonas sp.
Herga, S.; Brutus, A.; Vitale, R.M.; Miche, H.; Perrier, J.; Puigserver, A.; Scaloni, A.; Giardina, T.
Site-directed mutagenesis and molecular modelling studies show the role of Asp82 and cysteines in rat acylase 1, a member of the M20 family
Biochem. Biophys. Res. Commun.
330
540-546
2005
Rattus norvegicus (Q6AYS7)
Kim, S.H.; Yan, Y.B.; Zhou, H.M.
Role of osmolytes as chemical chaperones during the refolding of aminoacylase
Biochem. Cell Biol.
84
30-38
2006
Sus scrofa
Lindner, H.A.; Alary, A.; Boju, L.I.; Sulea, T.; Menard, R.
Roles of dimerization domain residues in binding and catalysis by aminoacylase-1
Biochemistry
44
15645-15651
2005
Homo sapiens
Nguyen, K.T.; Pei, D.
Purification and characterization of enzymes involved in the degradation of chemotactic N-formyl peptides
Biochemistry
44
8514-8522
2005
Rattus norvegicus
Kim, S.H.; Zhang, J.; Jiang, Y.; Zhou, H.M.; Yan, Y.B.
Assisting the reactivation of guanidine hydrochloride-denatured aminoacylase by hydroxypropyl cyclodextrins
Biophys. J.
91
686-693
2006
Sus scrofa
Perrier, J.; Durand, A.; Giardina, T.; Puigserver, A.
The rat kidney acylase 1. Evidence for a new cDNA form and comparisons with the porcine intestinal enzyme
Comp. Biochem. Physiol. B
138B
277-283
2004
Rattus norvegicus (Q6AYS7), Sus scrofa (P37111)
-
Maceyka, M.; Nava, V.E.; Milstien, S.; Spiegel, S.
Aminoacylase 1 is a sphingosine kinase 1-interacting protein
FEBS Lett.
568
30-34
2004
Mus musculus
Xie, Q.; Zhou, H.M.
Refolding intermediate of guanidine hydrochloride denatured aminoacylase
Int. J. Biochem. Cell Biol.
36
1332-1340
2004
Sus scrofa
Koreishi, M.; Zhang, D.; Imanaka, H.; Imamura, K.; Adachi, S.; Matsuno, R.; Nakanishi, K.
A novel acylase from Streptomyces mobaraensis that efficiently catalyzes hydrolysis/synthesis of capsaicins as well as N-acyl-L-amino acids and N-acyl-peptides
J. Agric. Food Chem.
54
72-78
2006
Streptomyces mobaraensis
Groger, H.; Trauthwein, H.; Buchholz, S.; Drauz, K.; Sacherer, C.; Godfrin, S.; Werner, H.
The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids
Org. Biomol. Chem.
2
1977-1978
2004
Sus scrofa
Youshko, M.I.; van Langen, L.M.; Sheldon, R.A.; Svedas, V.K.
Application of aminoacylase I to the enantioselective resolution of alpha-amino acid esters and amides
Tetrahedron
15
1933-1936
2004
Aspergillus melleus
-
Lindner, H.A.; Alary, A.; Wilke, M.; Sulea, T.
Probing the acyl-binding pocket of aminoacylase-1
Biochemistry
47
4266-4275
2008
Sus scrofa, Homo sapiens (Q03154), Homo sapiens
Lindner, H.A.; Taefler-Naumann, M.; Roehm, K.H.
N-acetylamino acid utilization by kidney aminoacylase-1
Biochimie
90
773-780
2008
Homo sapiens (Q03154), Homo sapiens, Sus scrofa (P37111), Sus scrofa
Su, J.T.; Kim, S.H.; Yan, Y.B.
Dissecting the pretransitional conformational changes in aminoacylase I thermal denaturation
Biophys. J.
92
578-587
2007
Sus scrofa
Hsu, S.K.; Lo, H.H.; Kao, C.H.; Lee, D.S.; Hsu, W.H.
Enantioselective synthesis of L-homophenylalanine by whole cells of recombinant Escherichia coli expressing L-aminoacylase and N-acylamino acid racemase genes from Deinococcus radiodurans BCRC12827
Biotechnol. Prog.
22
1578-1584
2006
Deinococcus radiodurans
Newman, D.; Abuladze, N.; Scholz, K.; Dekant, W.; Tsuprun, V.; Ryazantsev, S.; Bondar, G.; Sassani, P.; Kurtz, I.; Pushkin, A.
Specificity of aminoacylase III-mediated deacetylation of mercapturic acids
Drug Metab. Dispos.
35
43-50
2007
Mus musculus (Q99JW2), Mus musculus
Tanimoto, K.; Higashi, N.; Nishioka, M.; Ishikawa, K.; Taya, M.
Characterization of thermostable aminoacylase from hyperthermophilic archaeon Pyrococcus horikoshii
FEBS J.
275
1140-1149
2008
Pyrococcus horikoshii (O58453), Pyrococcus horikoshii
Ryazantsev, S.; Abuladze, N.; Newman, D.; Bondar, G.; Kurtz, I.; Pushkin, A.
Structural characterization of dimeric murine aminoacylase III
FEBS Lett.
581
1898-1902
2007
Mus musculus (Q99JW2), Mus musculus
Kim, S.H.; Zhou, H.M.; Yan, Y.B.
Effects of hydroxypropyl cyclodextrins on the reactivation of SDS-denatured aminoacylase
Int. J. Biol. Macromol.
40
76-82
2007
Sus scrofa
Liu, Z.; Zhen, Z.; Zuo, Z.; Wu, Y.; Liu, A.; Yi, Q.; Li, W.
Probing the catalytic center of porcine aminoacylase 1 by site-directed mutagenesis, homology modeling and substrate docking
J. Biochem.
139
421-430
2006
Sus scrofa (P37111), Sus scrofa
Lin, L.L.; Chen, M.H.; Chien, H.C.; Kan, S.C.; Chen, C.C.; Hu, H.Y.; Hsu, W.H.
Characterization of a bifunctional aminoacylase/carboxypeptidase from radioresistant bacterium Deinococcus radiodurans R1
J. Biotechnol.
128
322-334
2007
Deinococcus radiodurans
Wardenga, R.; Hollmann, F.; Thum, O.; Bornscheuer, U.
Functional expression of porcine aminoacylase 1 in E. coli using a codon optimized synthetic gene and molecular chaperones
Appl. Microbiol. Biotechnol.
81
721-729
2008
Sus scrofa (P37111), Sus scrofa
Nishioka, M.; Tanimoto, K.; Higashi, N.; Fukada, H.; Ishikawa, K.; Taya, M.
Alteration of metal ions improves the activity and thermostability of aminoacylase from hyperthermophilic archaeon Pyrococcus horikoshii
Biotechnol. Lett.
30
1639-1643
2008
Pyrococcus horikoshii
Zhong, Y.; Onuki, J.; Yamasaki, T.; Ogawa, O.; Akatsuka, S.; Toyokuni, S.
Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma
Carcinogenesis
30
158-164
2009
Rattus norvegicus (Q6AYS7)
Tsirulnikov, K.; Abuladze, N.; Newman, D.; Ryazantsev, S.; Wolak, T.; Magilnick, N.; Koag, M.C.; Kurtz, I.; Pushkin, A.
Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel
Biochim. Biophys. Acta
1794
1049-1057
2009
Homo sapiens, Mus musculus
Wardenga, R.; Lindner, H.A.; Hollmann, F.; Thum, O.; Bornscheuer, U.
Increasing the synthesis/hydrolysis ratio of aminoacylase 1 by site-directed mutagenesis
Biochimie
92
102-109
2010
Sus scrofa (P37111), Sus scrofa
Dong, T.; Zhao, L.; Huang, Y.; Tan, X.
Preparation of cross-linked aggregates of aminoacylase from Aspergillus melleus by using bovine serum albumin as an inert additive
Biores. Technol.
101
6569-6571
2010
Aspergillus melleus
Koreishi, M.; Nakatani, Y.; Ooi, M.; Imanaka, H.; Imamura, K.; Nakanishi, K.
Purification, characterization, molecular cloning, and expression of a new aminoacylase from Streptomyces mobaraensis that can hydrolyze N-(middle/long)-chain-fatty-acyl-L-amino acids as well as N-short-chain-acyl-L-amino acids
Biosci. Biotechnol. Biochem.
73
1940-1947
2009
Streptomyces mobaraensis (C9K2Z6), Streptomyces mobaraensis
Gan, M.; He, D.; Fan, C.; Zhao, H.; Guan, J.
Optical resolution and separation of D-aromatic amino acid by aminoacylase from Aspergillus oryzae
Chin. J. Appl. Environ. Biol.
15
734-736
2009
Aspergillus oryzae
-
Hsieh, J.M.; Tsirulnikov, K.; Sawaya, M.R.; Magilnick, N.; Abuladze, N.; Kurtz, I.; Abramson, J.; Pushkin, A.
Structures of aminoacylase 3 in complex with acetylated substrates
Proc. Natl. Acad. Sci. USA
107
17962-17967
2010
Mus musculus
Stocker, P.; Brunel, J.; de Rezende, L.; -do Amaral, A.; Morelli, X.; Roche, P.; Vidal, N.; Giardina, T.; Perrier, J.
Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides
Biochimie
94
1668-1675
2012
Homo sapiens, Sus scrofa (P37111), Sus scrofa
Kuhns, E.H.; Seidl-Adams, I.; Tumlinson, J.H.
A lepidopteran aminoacylase (L-ACY-1) in Heliothis virescens (Lepidoptera: Noctuidae) gut lumen hydrolyzes fatty acid-amino acid conjugates, elicitors of plant defense
Insect Biochem. Mol. Biol.
42
32-40
2012
Heliothis virescens (G8EJ32), Heliothis virescens
Parker, B.M.; Taylor, I.N.; Woodley, J.M.; Ward, J.M.; Dalby, P.A.
Directed evolution of a thermostable l-aminoacylase biocatalyst
J. Biotechnol.
155
396-405
2011
Thermococcus litoralis
Ngamsom, B.; Hickey, A.; Greenway, G.; Littlechild, J.; Watts, P.; Wiles, C.
Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme
J. Mol. Catal. B
63
81-86
2010
Thermococcus litoralis
-
Ishikawa, K.; Ishida, H.; Matsui, I.; Kawarabayasi, Y.; Kikuchi, H.
Novel bifunctional hyperthermostable carboxypeptidase/aminoacylase from Pyrococcus horikoshii OT3
Appl. Environ. Microbiol.
67
673-679
2001
Pyrococcus horikoshii (O58754), Pyrococcus horikoshii, Pyrococcus horikoshii OT-3 (O58754)
Toogood, H.S.; Hollingsworth, E.J.; Brown, R.C.; Taylor, I.N.; Taylor, S.J.; McCague, R.; Littlechild, J.A.
A thermostable L-aminoacylase from Thermococcus litoralis: cloning, overexpression, characterization, and applications in biotransformations
Extremophiles
6
111-122
2002
Thermococcus litoralis
Hollingsworth, E.J.;Isupov, M.N.; Littlechild, J.A.
Crystallization and preliminary X-ray diffraction analysis of L-aminoacylase from the hyperthermophilic archaeon Thermococcus litoralis
Acta Crystallogr. Sect. D
58
507-510
2002
Thermococcus litoralis
Shi, H.; Hayes, M.T.; Kirana, C.; Miller, R.J.; Keating, J.P.; Stubbs, R.S.
Overexpression of aminoacylase 1 is associated with colorectal cancer progression
Hum. Pathol.
44
1089-1097
2013
Homo sapiens (Q03154), Homo sapiens
Anila, A.H.; Ali, F.; Kushwaha, S.; Taye, N.; Chattopadhyay, S.; Das, A.
A cysteine-specific fluorescent switch for monitoring oxidative stress and quantification of aminoacylase-1 in blood serum
Anal. Chem.
88
12161-12168
2016
Homo sapiens (Q03154)
Adenan, S.; Wong, C.; Zain, H.; Azziz, S.; Rahman, R.
Characterization of thermostable aminoacylase from Geobacillus sp. strain SZN
Asia Pac. J. Mol. Biol. Biotechnol.
27
1-9
2019
Geobacillus sp., Geobacillus sp. SZN
-
Cheng, Q.; Gu, S.; Liu, Z.; Wang, C.Z.; Li, X.
Expressional divergence of the fatty acid-amino acid conjugate-hydrolyzing aminoacylase 1 (L-ACY-1) in Helicoverpa armigera and Helicoverpa assulta
Sci. Rep.
7
8721
2017
Helicoverpa assulta (A0A219YQV4), Helicoverpa assulta, Helicoverpa armigera (G8EJ34), Helicoverpa armigera
Keller, J.W.; Hamilton, B.J.
Enzymatic resolution of 2-trifluoromethylalanine
Tetrahedron Lett.
27
1249-1250
1986
Sus scrofa
-
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