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2',3'-dichloropropionanilide + H2O
2,3-dichloroaniline + propionate
-
14% of the activity with 3',4'-dichloropropionanilide
-
-
?
2',4'-dichloropropionanilide + H2O
2,4-dichloroaniline + propionate
-
49% of the activity with 3',4'-dichloropropionanilide
-
-
?
2',6'-dimethylacetanilide + H2O
?
2'-chloropropionanilide + H2O
2-chloroaniline + propionate
-
37% of the activity with 3',4'-dichloropropionanilide
-
-
?
2,5-dimethylfuran-3-carboxanilide + H2O
?
-
-
-
-
?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
2-nitrotrifluoroacetanilide + H2O
2-nitroaniline + trifluoroacetic acid
acetylcholinesterase exhibits two different activities: esterase and aryl acylamidase
-
-
?
3',4'-dichloro-2-methacrylanilide + H2O
3,4-dichloroaniline + 2-methyl-2-propenoate
-
8% of the activity with 3',4'-dichloropropionanilide
-
-
?
3',4'-dichloroacetanilide + H2O
3,4-dichloroaniline + acetate
-
49% of the activity with 3',4'-dichloropropionanilide
-
-
?
3',4'-dichlorobutyranilide + H2O
3,4-dichloroaniline + butyrate
-
37% of the activity with 3',4'-dichloropropionanilide
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
3',4'-dichlorovaleranilide + H2O
3,4-dichloroaniline + pentanoate
-
12% of the activity with 3',4'-dichloropropionanilide
-
-
?
3'-chloropropionanilide + H2O
3-chloroaniline + propionate
-
51% of the activity with 3',4'-dichloropropionanilide
-
-
?
3,4-dichloropropionanilide + H2O
?
-
plants with significant amounts of aryl acylamidase are able to hydrolyze acylanilide herbicides quickly and thereby avoid the toxic effects of these compounds
-
-
?
3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea + H2O
3,4-dichloroaniline + ?
-
i.e. linuron
-
?
3-(acetamido)N,N,N-trimethylanilinium + H2O
3-amino-N,N,N-trimethylanilinium + acetic acid
-
-
-
-
?
4'-chloropropionanilide + H2O
4-chloroaniline + propionate
-
54% of the activity with 3',4'-dichloropropionanilide
-
-
?
4-acetamidophenol + H2O
acetate + 4-aminophenol
4-acetylaminobenzaldehyde thiosemicarbazone + H2O
4-aminobenzaldehyde thiosemicarbazone + acetic acid
-
i.e. thiacetazone
-
?
4-chloroacetanilide + H2O
acetate + 4-chloroaniline
-
-
-
r
4-nitroacetanilide + H2O
4-nitroaniline + acetate
4-nitroacetanilide + H2O
acetate + 4-nitroaniline
-
-
-
r
4-nitrophenyl acetate + H2O
?
-
-
-
-
?
acetamide + H2O
acetic acid + NH3
-
-
-
-
?
acetaminophen + H2O
4-aminophenol + acetate
-
i.e. paracetamol
-
?
acetanilide + H2O
acetate + aniline
adipic acid bishexylamide + H2O
adipic acid + dihexylamine
-
-
-
-
?
Ala-NH2 + H2O
Ala + NH3
-
-
-
-
?
Asp-p-nitroanilide + H2O
Asp + p-nitroaniline
-
-
-
-
?
asparagine + H2O
aspartic acid + NH3
-
-
-
-
?
benzamide + H2O
benzoate + NH3
-
-
-
?
benzamide + H2O
benzoic acid + NH3
-
-
-
-
?
butyramide + H2O
butanoic acid + NH3
-
-
-
-
?
Gly-2-naphthylamide + H2O
Gly 2-naphthylamine
Gly-p-nitroanilide + H2O
Gly + p-nitroaniline
-
-
-
-
?
Gly-Phe-NH2 + H2O
Gly-Phe + NH3
-
-
-
-
?
Gly-Pro-Leu-p-nitroanilide + H2O
Gly-Pro-Leu + p-nitroaniline
-
-
-
-
?
hexanoamide + ?
hexanoic acid + NH3
-
-
-
-
?
hydroxyacetanilide + H2O
hydroxyaniline + acetate
-
-
-
-
?
L-Ala beta-naphthylamide + H2O
Ala + beta-naphthylamine
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
Ala + p-nitroaniline
-
-
-
-
?
L-Arg beta-naphthylamide + H2O
Arg + beta-naphthylamine
-
-
-
-
?
L-Glu-beta-naphthylamide + H2O
Glu + beta-naphthylamine
-
-
-
-
?
L-Leu beta-naphthylamide + H2O
Leu + beta-naphthylamine
-
-
-
-
?
L-Leu p-nitroanilide + H2O
Leu + p-nitroaniline
L-Leu-beta-naphthylamide + H2O
Leu + beta-naphthylamine
-
-
-
-
?
L-Leu-L-Ala + H2O
Leu + Ala
-
-
-
-
?
L-Leu-L-Phe + H2O
Leu + Phe
-
-
-
-
?
L-Leu-L-Tyr + H2O
Leu + Tyr
-
-
-
-
?
L-Leu-L-Val + H2O
Leu + Val
-
-
-
-
?
L-Lys beta-naphthylamide + H2O
Lys + beta-naphthylamine
-
-
-
-
?
L-Met beta-naphthylamide + H2O
Met + beta-naphthylamine
-
-
-
-
?
Leu-Gly-NH2 + H2O
Leu-Gly + NH3
-
-
-
-
?
Leu-NH2 + H2O
Leu + NH3
-
-
-
-
?
mandelamine + H2O
mandelic acid + NH3
-
-
-
-
?
methacrylamide + H2O
methacrylic acid + NH3
-
-
-
-
?
N-(2,4-dinitrophenyl)acetamide + H2O
N-(2,4-dinitrophenyl)aniline + acetate
-
-
-
-
?
N-(2-nitrophenyl)-trifluoroacetamide + H2O
2-nitroaniline + trifluoroacetic acid
N-(2-nitrophenyl)acetamide + H2O
N-(2-nitrophenyl)aniline + acetate
N-(2-nitrophenyl)benzamide + H2O
N-(2-nitrophenyl)aniline + benzoic acid
-
no activity with acetylcholinesterase
-
-
?
N-(2-nitrophenyl)butanamide + H2O
N-(2-nitrophenyl)aniline + butyrate
N-(2-nitrophenyl)heptanamide + H2O
N-(2-nitrophenyl)aniline + heptanoate
-
-
-
-
?
N-(2-nitrophenyl)hexanacetamide + H2O
N-(2-nitrophenyl)aniline + hexanoate
N-(2-nitrophenyl)octanamide + H2O
N-(2-nitrophenyl)aniline + octanoate
-
-
-
-
?
N-(2-nitrophenyl)pentanacetamide + H2O
N-(2-nitrophenyl)aniline + pentanoate
N-(2-nitrophenyl)phenylacetamide + H2O
N-(2-nitrophenyl)aniline + phenylacetate
-
-
-
-
?
N-(2-nitrophenyl)propanamide + H2O
N-(2-nitrophenyl)aniline + propionate
N-(2-nitrophenyl)trifluoroacetamide + H2O
N-(2-nitrophenyl)aniline + trifluoroacetate
N-(3,4-dichlorophenyl) propanamide + H2O
3,4-dichloroaniline + propanoic acid
i.e. propanil
-
-
?
N-(3,4-dichlorophenyl)propanamide + H2O
3,4-dichloraniline + propanoate
no activity with butachlor, acetochlor, 4-nitroacetanilide, p-chloracetanilide
-
-
?
N-(3-methoxy-2-nitrophenyl)acetamide + H2O
N-(3-methoxy-2-nitrophenyl)aniline + acetate
N-(3-nitrophenyl)acetamide + H2O
N-(3-nitrophenyl)aniline + acetate
-
-
-
-
?
N-(4-nitrophenyl)acetamide + H2O
N-(4-nitrophenyl)aniline + acetate
-
-
-
-
?
N-(5-methoxy-2-nitrophenyl)acetamide + H2O
N-(5-methoxy-2-nitrophenyl)aniline + acetate
N-(o-nitrophenyl)trifluoroacetamide + ?
2-nitroaniline + trifluoracetic acid
-
aryl acylamidase activity of fatty acid-free human serum albumin
-
-
?
N-phenylacetamide + H2O
N-phenylaniline + acetate
-
-
-
-
?
Nalpha-benzoyl-DL-Arg beta-naphthylamide + H2O
Nalpha-benzoyl-DL-Arg + beta-naphthylamine
-
-
-
-
?
nicotinamide + H2O
nicotinic acid + NH3
-
-
-
-
?
o-nitroacetanilide + H2O
2-nitroaniline + acetate
o-nitroacetanilide + H2O
2-nitroaniline + acetic acid
o-nitroacetanilide + H2O
o-nitroaniline + acetate
-
-
-
-
?
o-nitrotrifluoroacetanilide + H2O
o-nitroaniline + trifluoroacetic acid
-
reaction is performed by human serum albumin, substrate is more reactive than o-nitroacetanilide
-
-
?
p-nitroacetanilide + H2O
4-nitroaniline + acetate
p-nitroacetanilide + H2O
4-nitroaniline + acetic acid
-
-
-
-
?
p-nitroacetanilide + H2O
p-nitroaniline + acetate
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
-
r
Phe-NH2 + H2O
Phe + NH3
-
-
-
-
?
phenacetin + H2O
acetate + 4-ethoxyaniline
Pro-NH2 + H2O
Pro + NH3
-
-
-
-
?
propanamide + H2O
propanoic acid + NH3
-
-
-
?
propionamide + H2O
propanoic acid + NH3
-
-
-
-
?
stearamide + H2O
stearic acid + NH3
-
-
-
-
?
Val-beta-naphthylamide + H2O
Val + beta-naphthylamine
-
-
-
-
?
additional information
?
-
2',6'-dimethylacetanilide + H2O
?
-
-
-
?
2',6'-dimethylacetanilide + H2O
?
-
-
-
?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
-
-
-
-
?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
-
-
-
-
?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
-
-
-
-
?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
-
-
-
-
?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
-
-
-
?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
-
the reaction in human erythrocytes and plasma is performed by the butyrylcholinesterase, EC 3.1.1.8, which is inactive with butyrylthiocholine, also fatty acid free human albumin has aryl acylacylamidase activity, which accounts for 10% of total human enzyme activity
-
-
?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
acetylcholinesterase exhibits two different activities: esterase and aryl acylamidase
-
-
?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
Oryza collina
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
Oryza malabarensis
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
i.e. propanil
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
i.e. propanil
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
i.e. propanil
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
i.e. propanil
-
-
?
3',4'-dichloropropionanilide + H2O
3,4-dichloroaniline + propionate
-
-
-
-
?
4-acetamidophenol + H2O
acetate + 4-aminophenol
i.e. Tylenol
-
-
r
4-acetamidophenol + H2O
acetate + 4-aminophenol
i.e. Tylenol. The enzyme contains a revealed a conserved amidase signature region with a canonical catalytic triad
-
-
r
4-nitroacetanilide + H2O
4-nitroaniline + acetate
-
-
-
-
?
4-nitroacetanilide + H2O
4-nitroaniline + acetate
-
-
-
-
?
acetanilide + H2O
acetate + aniline
-
-
-
r
acetanilide + H2O
acetate + aniline
-
-
-
-
?
acetanilide + H2O
acetate + aniline
-
-
-
-
?
Gly-2-naphthylamide + H2O
Gly 2-naphthylamine
-
-
-
-
?
Gly-2-naphthylamide + H2O
Gly 2-naphthylamine
-
-
-
-
?
L-Leu p-nitroanilide + H2O
Leu + p-nitroaniline
-
-
-
-
?
L-Leu p-nitroanilide + H2O
Leu + p-nitroaniline
-
-
-
-
?
L-Leu p-nitroanilide + H2O
Leu + p-nitroaniline
-
-
-
-
?
N-(2-nitrophenyl)-trifluoroacetamide + H2O
2-nitroaniline + trifluoroacetic acid
-
-
-
-
?
N-(2-nitrophenyl)-trifluoroacetamide + H2O
2-nitroaniline + trifluoroacetic acid
-
-
-
-
?
N-(2-nitrophenyl)acetamide + H2O
N-(2-nitrophenyl)aniline + acetate
-
-
-
-
?
N-(2-nitrophenyl)acetamide + H2O
N-(2-nitrophenyl)aniline + acetate
-
-
-
-
?
N-(2-nitrophenyl)butanamide + H2O
N-(2-nitrophenyl)aniline + butyrate
-
no activity with acetylcholinesterase
-
-
?
N-(2-nitrophenyl)butanamide + H2O
N-(2-nitrophenyl)aniline + butyrate
-
-
-
-
?
N-(2-nitrophenyl)hexanacetamide + H2O
N-(2-nitrophenyl)aniline + hexanoate
-
no activity with acetylcholinesterase
-
-
?
N-(2-nitrophenyl)hexanacetamide + H2O
N-(2-nitrophenyl)aniline + hexanoate
-
-
-
-
?
N-(2-nitrophenyl)pentanacetamide + H2O
N-(2-nitrophenyl)aniline + pentanoate
-
-
-
-
?
N-(2-nitrophenyl)pentanacetamide + H2O
N-(2-nitrophenyl)aniline + pentanoate
-
-
-
-
?
N-(2-nitrophenyl)propanamide + H2O
N-(2-nitrophenyl)aniline + propionate
-
-
-
-
?
N-(2-nitrophenyl)propanamide + H2O
N-(2-nitrophenyl)aniline + propionate
-
-
-
-
?
N-(2-nitrophenyl)trifluoroacetamide + H2O
N-(2-nitrophenyl)aniline + trifluoroacetate
-
best substrate of acetylcholinesterase and butyrylcholinesterase
-
-
?
N-(2-nitrophenyl)trifluoroacetamide + H2O
N-(2-nitrophenyl)aniline + trifluoroacetate
-
-
-
-
?
N-(3-methoxy-2-nitrophenyl)acetamide + H2O
N-(3-methoxy-2-nitrophenyl)aniline + acetate
-
no activity with acetylcholinesterase
-
-
?
N-(3-methoxy-2-nitrophenyl)acetamide + H2O
N-(3-methoxy-2-nitrophenyl)aniline + acetate
-
-
-
-
?
N-(5-methoxy-2-nitrophenyl)acetamide + H2O
N-(5-methoxy-2-nitrophenyl)aniline + acetate
-
-
-
-
?
N-(5-methoxy-2-nitrophenyl)acetamide + H2O
N-(5-methoxy-2-nitrophenyl)aniline + acetate
-
-
-
-
?
o-nitroacetanilide + H2O
2-nitroaniline + acetate
-
-
-
-
?
o-nitroacetanilide + H2O
2-nitroaniline + acetate
-
-
-
-
?
o-nitroacetanilide + H2O
2-nitroaniline + acetate
-
-
-
-
?
o-nitroacetanilide + H2O
2-nitroaniline + acetate
-
-
-
-
?
o-nitroacetanilide + H2O
2-nitroaniline + acetate
-
-
-
-
?
o-nitroacetanilide + H2O
2-nitroaniline + acetate
-
i.e. 2-nitroacetanilide
-
-
?
o-nitroacetanilide + H2O
2-nitroaniline + acetate
-
i.e. 2-nitroacetanilide
-
-
?
o-nitroacetanilide + H2O
2-nitroaniline + acetate
-
-
-
-
?
o-nitroacetanilide + H2O
2-nitroaniline + acetic acid
-
-
-
-
?
o-nitroacetanilide + H2O
2-nitroaniline + acetic acid
-
-
-
-
?
p-acetotoluidide + H2O
?
-
-
-
?
p-acetotoluidide + H2O
?
-
-
-
?
p-nitroacetanilide + H2O
4-nitroaniline + acetate
-
i.e. 4-nitroacetanilide
-
-
?
p-nitroacetanilide + H2O
4-nitroaniline + acetate
-
-
-
-
?
p-nitroacetanilide + H2O
4-nitroaniline + acetate
-
i.e. 4-nitroacetanilide
-
-
?
p-nitroacetanilide + H2O
p-nitroaniline + acetate
-
studies on the mechanism of the reaction
-
-
r
p-nitroacetanilide + H2O
p-nitroaniline + acetate
-
enzymatic activity measured by absorbance spectroscopy at 382 nm
-
-
?
phenacetin + H2O
acetate + 4-ethoxyaniline
-
-
-
r
phenacetin + H2O
acetate + 4-ethoxyaniline
i.e. N-(4-ethoxyphenyl)acetamide
-
-
r
additional information
?
-
-
induction by 2',6'-dimethylacetanilide
-
-
?
additional information
?
-
-
induction by acetanilide, 2'-methylacetanilide, 3'-methylacetanilide, 4'-methylacetanilide
-
-
?
additional information
?
-
-
induction by 2',6'-dimethylacetanilide
-
-
?
additional information
?
-
-
induction by acetanilide, 2'-methylacetanilide, 3'-methylacetanilide, 4'-methylacetanilide
-
-
?
additional information
?
-
-
induction by acetanilide, 2'-methylacetanilide, 3'-methylacetanilide, 4'-methylacetanilide
-
-
?
additional information
?
-
-
strain MAB2: constitutive enzyme
-
-
?
additional information
?
-
-
induction by 2',6'-dimethylacetanilide
-
-
?
additional information
?
-
-
induction by acetanilide, 2'-methylacetanilide, 3'-methylacetanilide, 4'-methylacetanilide
-
-
?
additional information
?
-
-
induction by 2',6'-dimethylacetanilide
-
-
?
additional information
?
-
-
induction by acetanilide, 2'-methylacetanilide, 3'-methylacetanilide, 4'-methylacetanilide
-
-
?
additional information
?
-
-
the aryl amide activity of the acetylcholinesterase has a distinct role in embryogenesis
-
-
?
additional information
?
-
-
acetylcholinesterase, EC 3.1.1.7, exhibits aryl acylamidase activity
-
-
?
additional information
?
-
-
amino acid sequence around the reactive serine residue is Gly-Ser-Ile
-
-
?
additional information
?
-
-
inducible enzyme
-
-
?
additional information
?
-
-
serotonin-sensitive aryl acylamidase is identical with acetylcholinesterase
-
-
?
additional information
?
-
-
serotonin-sensitive aryl acylamidase is identical with acetylcholinesterase
-
-
?
additional information
?
-
-
serotonin-sensitive aryl acylamidase is identical with acetylcholinesterase
-
-
?
additional information
?
-
-
enzyme also has acetylcholinesterase activity
-
-
?
additional information
?
-
-
enzyme also has butyrylcholinesterase activity
-
-
?
additional information
?
-
-
enzyme also has butyrylcholinesterase activity
-
-
?
additional information
?
-
-
serotonin-sensitive aryl acylamidase is identical with acetylcholinesterase
-
-
?
additional information
?
-
-
enzyme also has butyrylcholinesterase activity
-
-
?
additional information
?
-
-
acetylcholinesterase, EC 3.1.1.7, and butyrylcholinesterase, EC 3.1.1.8, exhibit also aryl acylamidase activity
-
-
?
additional information
?
-
-
serotonin-sensitive aryl acylamidase is identical with acetylcholinesterase
-
-
?
additional information
?
-
-
the aryl acylamidase activity, especially of butyrylcholinesterase, is involved in the development of the nervous system and in pathological processes such as the formation of neuritic plaques in Alzheimer's disease
-
-
?
additional information
?
-
-
the reaction in human erythrocytes and plasma is performed by the butyrylcholinesterase, EC 3.1.1.8, which is inactive with butyrylthiocholine, also fatty acid free human albumin has aryl acylacylamidase activity, which accounts for 10% of total human enzyme activity
-
-
?
additional information
?
-
-
acetylcholinesterase, EC 3.1.1.7, and butyrylcholinesterase, EC 3.1.1.8, also show aryl acylamidase activity using the same active site for both reactions, structure-activity relationship analysis, overview, substrate specificity of the aryl amidase activity, overview, no activity with N-(2,4-dinitrophenyl)acetamide, N-(4-nitrophenyl)aniline, N-(3-nitrophenyl)aniline, N-phenylacetamide, N-phenylbenzamide, N-(2-nitrophenyl)-3,3-dimethylbutanamide, N-methyl-N-(2-nitrophenyl)acetamide, N-methyl-N-(2-nitrophenyl)butanamide, N-phenyltrifluoroacetamide, and N-(2,6-dinitrophenyl)acetamide
-
-
?
additional information
?
-
-
inducible by various phenylamides of the acylanilide, phenylcarbamate, and methoxysubstituted phenylurea type
-
-
?
additional information
?
-
-
surface hydrolysis of polyamide 6
-
-
?
additional information
?
-
-
serotonin-sensitive aryl acylamidase is identical with acetylcholinesterase
-
-
?
additional information
?
-
substrate specificity, overview. PamH is highly active on aromatic and short-chain aliphatic amides, e.g. benzamide and propionamide, moderately active on amino acid amides, and possesses weak urease activity. Of the anilides examined, only propanil is a good substrate for PamH. PamH is also able to catalyze the acyl transfer reaction to hydroxylamine for both amide and anilide substrates, including acetamide, propanil, and 4-nitroacetanilide, it shows the highest reaction rate with isobutyramide
-
-
?
additional information
?
-
the PamH enzyme exhibits amidase activity, aryl acylamidase activity (EC 3.5.1.13), and acyl transferase activity. It shows excellent activity toward the majority of the aromatic and aliphatic amides, such as acetamide, propionamide, phenylacetamide, and benzamide. The aromatic amides, with substitutions of one or two carbons in the ring by a nitrogen, have a negative influence on amidase activity, leading to low specific activity values for pyrazinamide and nicotinamide. No activity is detectable on long-chain aliphatic amide hexanoamides. Amino acid amides are also hydrolyzed by the enzyme. The enzyme possesses urease activity, but N-methyl substituted is not hydrolyzed by the enzyme. The amidase shows low activity on asparagines (9%), L-glutamine (17%), and D-glutamine (13%) corresponding to benzamide (100%). The anilide substrate range of the enzyme is very narrow and cannot hydrolyze butachlor, acetochlor, 4-nitroacetanilide, p-chloroacetanilide, or other structurally analogous compounds
-
-
?
additional information
?
-
-
serotonin-sensitive aryl acylamidase is associated with acetylcholinesterase, serotonin-insensitive aryl acylamidase is not associated with acetylcholinesterase
-
-
?
additional information
?
-
-
structure-activity relationship analysis, overview, substrate specificity, overview, no activity with N-(2-nitrophenyl)benzamide, N-(2-nitrophenyl)phenylacetamide, N-(2-nitrophenyl)octanacetamide, N-(2-nitrophenyl)heptanacetamide, N-phenylbenzamide, N-(2-nitrophenyl)-3,3-dimethylbutanamide, N-methyl-N-(2-nitrophenyl)acetamide, N-methyl-N-(2-nitrophenyl)butanamide, N-phenyltrifluoroacetamide, and N-(2,6-dinitrophenyl)acetamide
-
-
?
additional information
?
-
-
constitutive enzyme
-
-
?
additional information
?
-
-
constitutive enzyme
-
-
?
additional information
?
-
-
induced by anilide, not subject to carbon or nitrogen repression by the growth medium
-
-
?
additional information
?
-
4-guanidinobutyramide probably is the natural substrate
-
-
?
additional information
?
-
substrate specificity, overview. The recombinant enzyme displays an unusually wide substrate spectrum. It is moderately active on short-chain aliphatic amides and weakly active hydrolyzing aromatic and heterocyclic amides. Recombinant His6-tagged enzyme Azl13 also catalyzes acyl transfer to hydroxylamine from acetamide or the herbicide propanil. The enzyme also shows amidase, EC 3.5.1.4, and hydroxylamine acyl transferase activity, EC 2.3.1.56. No activity with benzonitrile. phenylacetonitrile, Flutolanil, L-glutamine, and L-asparagine
-
-
?
additional information
?
-
4-guanidinobutyramide probably is the natural substrate
-
-
?
additional information
?
-
substrate specificity, overview. The recombinant enzyme displays an unusually wide substrate spectrum. It is moderately active on short-chain aliphatic amides and weakly active hydrolyzing aromatic and heterocyclic amides. Recombinant His6-tagged enzyme Azl13 also catalyzes acyl transfer to hydroxylamine from acetamide or the herbicide propanil. The enzyme also shows amidase, EC 3.5.1.4, and hydroxylamine acyl transferase activity, EC 2.3.1.56. No activity with benzonitrile. phenylacetonitrile, Flutolanil, L-glutamine, and L-asparagine
-
-
?
additional information
?
-
-
serotonin-sensitive aryl acylamidase is identical with acetylcholinesterase
-
-
?
additional information
?
-
-
key enzyme in plant herbicide detoxification
-
-
?
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1,2,3,4-tetrahydro-beta-carboline
1,5-bis(4-allyl-dimethylammonium-phenyl)pentan-3-one-dibromide
-
i.e. BW284c51, inhibition is more pronounced at older developmental stages
2-bromo-lysergic acid diethylamide
2-Hydroxy-5-nitrobenzyl bromide
4-chloromercuribenzoate
-
4-chloromercurybenzoate
-
5-methoxytryptamine
-
slight
6-hydroxy-tetrahydroharman
-
slight inhibition of enzyme form AAA-1 and AAA-2
acetyl-beta-methylcholine bromide
-
-
acetylthiocholine iodide
-
-
benzoylcholine chloride
-
-
Butyrylcholine iodide
-
-
Ca2+
inhibits 21.1% at 1 mM and 21.5% at 10 mM
Carbaryl
-
i.e. 1-naphthyl-N-methylcarbamate, complete inhibition at 0.5 mM
Cd2+
complete inhibition at 1 mM
CdCl2
-
1.0 mM, complete inactivation
chlorimipramine
-
enzyme form AAA-1
CoCl2
-
1.0 mM, 16% inhibition
cyproheptadine
-
enzyme form AAA-1
d-lysergic acid diethylamide
diisopropylfluorophosphate
-
complete inhibition of aryl acylacylamidase activity of fatty acid free human albumin at 2 mM, covalent binding to the catalytic site Tyr411
diisopropylphosphofluoridate
donepezil
-
an Alzheimer drug
edrophonium
activity is reduced to 64.1% and 30.7% at 0.1 and 0.5 mM. Edrophonium inhibits esterase activity and aryl acylamidase activity of acetylcholinesterase
fatty acid
-
fatty acids block aryl acylamidase activity competing with amides for binding in the catalytic domain
FeCl3
-
1.0 mM, 6% inhibition
harmalol
-
enzyme form of AAA-1
harminic acid
-
slight inhibition of enzyme form AAA-1 and AAA-2
huperzine
-
an Alzheimer drug
malathion
-
0.06 mM, 75% loss of activity
methiothepin
-
enzyme form AAA-1
N,N-Dimethyltryptamine
-
slight
N-Acetylimidazole
-
stimulation at low concentrations, inactivation at high concentration
N-benzyl-N-dodecyl-N,N-dimethylammonium chloride
-
inhibitor at low substrate concentrations
o-Iodosobenzoate
-
0.25 mM, 27% inhibition
PMSF
10 mM: 9.8% activity; strong inhibition
propionylcholine chloride
-
-
puromycin
-
competitive inhibition of hydrolysis L-Ala-4-nitroanilide
pyridoxal 5'-phosphate
-
inactivates aryl acylamidase activity and acetylcholinesterase activity in absence of acetylcholine or 1,5-bis[4-(allyl-dimethylammonium)phenyl]pentan-3-one. Presence of acetylcholine or 1,5-bis[4-(allyl-dimethylammonium)phenyl]pentan-3-one prevents loss of acetylcholinesterase activity but not of aryl acylamidase activity
serotonin creatinine sulfate
Succinylcholine chloride
-
-
tetraisopropyldiphosphoramide
Tetranitromethane
-
stimulation at low concentrations, inactivation at high concentration
Trinitrobenzenesulfonic acid
tryptamine hydrochloride
-
-
tyramine
-
inhibitor of hydrolysis for charged substrates
Urea
-
6 M, irreversible inactivation
(+/-)-huperzine A
-
-
1,10-phenanthroline
-
-
1,10-phenanthroline
20-30% inhibition at 1 mM
1,2,3,4-tetrahydro-beta-carboline
-
-
1,2,3,4-tetrahydro-beta-carboline
-
-
1,2,3,4-tetrahydro-beta-carboline
-
competitive inhibition of AAA-1, slight inhibition of enzyme form AAA-2
2-bromo-lysergic acid diethylamide
-
marked inhibition of enzyme form AAA1 at pH 7.5, moderate inhibition of enzyme form AAA-1 at pH 5.5
2-bromo-lysergic acid diethylamide
-
-
2-Hydroxy-5-nitrobenzyl bromide
-
-
2-Hydroxy-5-nitrobenzyl bromide
-
inactivates aryl acylamidase activity and acetylcholinesterase activity in absence of acetylcholine or 1,5-bis[4-(allyl-dimethylammonium)phenyl]pentan-3-one. Presence of acetylcholine or 1,5-bis[4-(allyl-dimethylammonium)phenyl]pentan-3-one prevents loss of acetylcholinesterase activity but not of aryl acylamidase activity
2-mercaptoethanol
-
-
2-mercaptoethanol
52% inhibition at 1 mM
2-methyl-serotonin
-
-
Acetic anhydride
-
stimulation at low concentrations, inactivation at high concentration
Acetic anhydride
-
inactivates aryl acylamidase activity and acetylcholinesterase activity in absence of acetylcholine or 1,5-bis[4-(allyl-dimethylammonium)phenyl]pentan-3-one. Presence of acetylcholine or 1,5-bis[4-(allyl-dimethylammonium)phenyl]pentan-3-one prevents loss of acetylcholinesterase activity but not of aryl acylamidase activity
Acetylcholine
-
-
Acetylcholine
-
serotonin-sensitive aryl acylamidase is inhibited, serotonin-insensitive aryl acylamidase is not inhibited
Ag+
-
0.5 mM AgCl, complete inhibition
Ag+
-
0.1 mM, 6% inhibition
Ag+
-
1.0 mM AgNO3, complete inactivation
Ag+
-
1.0 mM AgNO3, marked inhibition
Ag+
complete inhibition at 1 mM
alpha-methyl-serotonin
-
-
alpha-methyl-serotonin
-
-
BW284c51
-
-
BW284c51
-
the specific AChE inhibitor inhibits the aryl amidase activity of acetylcholinesterase to a higher extent than the acetylcholinesterase activity
BW284c51
dual site binder, interacts with PAS and the active site of acetylcholinesterase, thus inhibiting both the activities (esterase and aryl acylamidase)
catechol
-
0.5 mM, 8.5% inhibition
catechol
-
0.5 mM, 73% inhibition
Co2+
inhibits 14.1% at 1 mM and 17.4% at 10 mM
Co2+
1 mM: 8.5% activity; strong inhibition
Cu2+
inhibits 13.4% at 1 mM and 45.7% at 10 mM
Cu2+
-
0.5 mM CuSO4, 65.5% loss of activity
Cu2+
-
0.1 mM, 9.5% inhibition
Cu2+
1 mM: 8.9% activity; strong inhibition
Cu2+
-
0.5 mM CuSO4, marked inhibition
Cu2+
complete inhibition at 1 mM
Cu2+
-
0.5 mM CuCl2, 86% inhibition
d-lysergic acid diethylamide
-
marked inhibition of enzyme form AAA1 at pH 7.5, moderate inhibition of enzyme form AAA-1 at pH 5.5
d-lysergic acid diethylamide
-
-
DFP
-
-
diethyl dicarbonate
-
-
diethyl dicarbonate
-
inactivates aryl acylamidase activity and acetylcholinesterase activity in absence of acetylcholine or 1,5-bis[4-(allyl-dimethylammonium)phenyl]pentan-3-one. Presence of acetylcholine or 1,5-bis[4-(allyl-dimethylammonium)phenyl]pentan-3-one prevents loss of acetylcholinesterase activity and of aryl acylamidase activity
diisopropylphosphofluoridate
-
complete inhibition at 1 mM , scarcely inhibited at 0.1 mM
diisopropylphosphofluoridate
-
-
EDTA
-
-
EDTA
20-30% inhibition at 1 mM
eserine
-
97% inhibition of aryl amidase activity at 0.01 mM
eserine
-
0.001 mM, nearly complete inhibition of serum and erythrocyte enzyme, liver enzyme is unaffected
eserine
-
0.01 mM, complete, non-competitive
heptyl-physostigmine
-
-
Hg2+
1 mM: 0% activity; complete inhibition
Hg2+
complete inhibition at 1 mM
HgCl2
-
-
HgCl2
-
0.1 mM, 98% inhibition
HgCl2
-
1.0 mM, complete inactivation
HgCl2
-
0.5 mM, 89% inhibition
iodoacetamide
-
-
iso-ompa
-
i.e. tetra-isopropyl-pyrophosphoramide, specific inhibitor for BChE, inhibits also the aryl amidase activity
iso-ompa
-
inhibitor of butyrylcholinesterase (BChE), also inhibits aryl acylamidase activity
N-bromosuccinimide
-
-
N-methylserotonin
-
-
NEM
-
-
NEM
-
1.0 mM, 23% inhibition
neostigmine
-
-
neostigmine
-
0.01 mM, nearly complete inhibition of serum and erythrocyte enzyme, liver enzyme is unaffected
neostigmine
-
0.01 mM, complete, non-competitive
neostigmine
-
inhibition of enzyme form AAA-2, no effect of enzyme form AAA-1
neostigmine bromide
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide or BW284C5
neostigmine bromide
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide or BW284C5
Ni2+
-
-
Ni2+
inhibits 26.0% at 1 mM and 43.2% at 10 mM
Ni2+
-
0.2 mM NiCl2, 50.2% inhibition
p-benzoquinone
-
-
p-benzoquinone
-
0.25 mM, 50% inhibition
PCMB
-
-
PCMB
-
0.25 mM, 61% inhibition
physostigmine
-
-
serotonin
-
80% inhibition of aryl amidase activity at 2 mM
serotonin
-
non-competitive
serotonin
-
0.5-5 mM, 38-97% inhibition
serotonin
-
inhibitor of butyrylcholinesterase (BChE), also inhibits aryl acylamidase activity
serotonin
serotonin inhibits aryl acylamidase while remaining ineffective against the esterase activity. It interacts with D74, N87, L76 and T83 residues of the side door
serotonin
-
strong inhibition
serotonin
-
serotonin-sensitive aryl acylamidase, serotonin-insensitive aryl acylamidase is not inhibited
serotonin
-
enzyme from brain is inhibited, liver enzyme is not inhibited; non-competitive
serotonin creatinine sulfate
-
-
serotonin creatinine sulfate
-
moderate inhibition of enzyme form AAA-1 at pH 7.5, no inhibition of enzyme form AAA-2 at pH 5.5
tacrine
-
-
tetraisopropyldiphosphoramide
-
weak
tetraisopropyldiphosphoramide
-
-
tetraisopropyldiphosphoramide
-
-
tetraisopropyldiphosphoramide
-
weak
tetraisopropyldiphosphoramide
-
weak
tetraisopropyldiphosphoramide
-
weak
Trinitrobenzenesulfonic acid
-
-
Trinitrobenzenesulfonic acid
-
inactivates aryl acylamidase activity and acetylcholinesterase activity in absence of acetylcholine or 1,5-bis[4-(allyl-dimethylammonium)phenyl]pentan-3-one. Presence of acetylcholine or 1,5-bis[4-(allyl-dimethylammonium)phenyl]pentan-3-one prevents loss of acetylcholinesterase activity but not of aryl acylamidase activity
tryptamine
-
slight inhibition of enzyme form AAA-1 at pH 7.5, no inhibition of enzyme form AAA-2 at pH 5.5
Zn2+
-
-
Zn2+
inhibits 40.0% at 1 mM and 75.8% at 10 mM
Zn2+
-
0.1 mM, 51% inhibition
additional information
-
the aryl acylamidase activity is associated with acetylcholinesterase in chicken embryonic brain, and is much more sensitive to Alzheimer drugs, huperzine and donepezil, especially at younger developmental stages, than the esterase activity of the acetylcholinesterase, whereas inhibition of esterase activity is sensitive to tacrine and DFP
-
additional information
by molecular docking studies the most favourable binding site of aryl acylamidase substrates and serotonin is identified as the side door of acetylcholinesterase. Propidium, a peripheral anionic site binder blocks the main door without affecting the side door, which explains its ineffectiveness in inhibiting aryl acylamidase
-
additional information
gallamine selectively inhibits the esterase activity to 63.6% (0.1 mM) and 45.4% (0.5 mM), whereas the aryl acylamidase activity remains significantly unaltered in the presence of gallamine (0.1 mM: 105.2%. 0.5 mM: 107%)
-
additional information
-
phosphatidylinositol-specific phospholipase C of Staphylococcus aureus or sodium deoxycholate-activated endogenous phospholipase C solubilizes serotonin-sensitive arylacylamidase , a loss of activity occurs which can be restored by externally added phosphatidylinositol
-
additional information
no effect by EDTA, 8-hydroxyquinoline, and 2-mercaptoethanol
-
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Boopathy, R.; Balasubramanian, A.S.
Chemical modification of the bifunctional human serum pseudocholinesterase. Effect on the pseudocholinesterase and aryl acylamidase activities
Eur. J. Biochem.
151
351-360
1985
Homo sapiens
brenda
Majumdar, R.; Balasubramanian, A.S.
Chemical modification of acetylcholinesterase from eel and basal ganglia: effect on the acetylcholinesterase and aryl acylamidase activities
Biochemistry
23
4088-4093
1984
Electrophorus electricus, Ovis aries
brenda
Villarreal, D.T.; Turco, R.F.; Konopka, A.
A structure-activity study with aryl acylamidases
Appl. Environ. Microbiol.
60
3939-3944
1994
Acinetobacter sp., Arthrobacter sp., Corynebacterium sp., Corynebacterium sp. DAK12, Acinetobacter sp. DV1
brenda
Gaynor, J.J.; Still, C.C.
Subcellular localization of rice leaf aryl acylamidase activity
Plant Physiol.
72
80-85
1983
Oryza sativa
brenda
Hammond, P.M.; Price, C.P.; Scawen, M.C.
Purification and properties of aryl acylamidase from Pseudomonas fluorescens ATCC 39004
Eur. J. Biochem.
132
651-655
1983
Pseudomonas fluorescens
brenda
Hsu, L.L.
Brain aryl acylamidase
Int. J. Biochem.
14
1037-1042
1982
Rattus norvegicus
brenda
Hsu, L.L.; Halaris, A.E.; Freedman, D.X.
Rat brain aryl acylamidase: further characterization of multiple forms
Int. J. Biochem.
14
581-584
1982
Rattus norvegicus
brenda
Majumdar, R.; Balasubramanian, A.S.
Essential and non-essential phosphatidylinositol residues in acetylcholinesterase and arylacylamidase of sheep basal ganglia
FEBS Lett.
146
335-338
1982
Ovis aries
brenda
George, S.T.; Balasubramanian, A.S.
The aryl acylamidases and their relationship to cholinesterases in human serum, erythrocyte and liver
Eur. J. Biochem.
121
177-186
1981
Homo sapiens
brenda
George, S.T.; Balasubramanian, A.S.
The identity of the serotonin-sensitive aryl acylamidase with acetylcholinesterase from human erythrocytes, sheep basal ganglia and electric eel
Eur. J. Biochem.
111
511-524
1980
Electrophorus electricus, Ovis aries, Homo sapiens
brenda
Oommen, A.; Balasubramanian, A.S.
The association of the serotonin-sensitive aryl acylamidase with acetylcholinesterase in the monkey brain
Eur. J. Biochem.
94
135-143
1979
Platyrrhini
brenda
Nakadai, T.; Nasuno, S.
Properties of arylamidase from Aspergillus oryzae
Agric. Biol. Chem.
42
1291-1292
1978
Aspergillus oryzae
-
brenda
Heymann, E.; Rix, H.
The active site of an inducible arylacylamidase from Pseudomonas acidovorans
Int. J. Pept. Protein Res.
11
59-64
1978
Delftia acidovorans
brenda
Hsu, L.L.; Paul, S.M.; Halaris, A.E.; Freedman, D.X.
Rat brain aryl acylamidase: multiple forms and inhibition effects of LSD, serotonin and related compounds
Life Sci.
20
857-866
1977
Rattus norvegicus
brenda
Fujimoto, D.
Serotonin-sensitive aryl acylamidase activity of acetylcholinesterase
FEBS Lett.
71
121-123
1976
Electrophorus electricus, Sus scrofa
brenda
Paul, S.M.; Halaris, A.E.
Rat brain de-acetylating activity: stereospecific inhibition by LSD and serotonin-related compounds
Biochem. Biophys. Res. Commun.
70
207-211
1976
Rattus norvegicus
brenda
Hoagland, R.E.
Hydrolysis of 3',4'-dichloropropionanilide by an aryl acylamidase from Taraxacum officinale
Phytochemistry
14
383-386
1975
Taraxacum officinale
-
brenda
Hoagland, R.E.; Graf, G.
The purification and properties of an amidohydrolase from soybean
Can. J. Biochem.
52
903-910
1974
Glycine max
brenda
Fujimoto, D.
Serotonin-sensitive aryl acylamidase in rat brain
Biochem. Biophys. Res. Commun.
61
72-74
1974
Rattus norvegicus
brenda
Engelhardt, G.; Wallnoefer, P.R.
Purification and properties of an aryl acylamidase of Bacillus sphaericus, catalyzing the hydrolysis of various phenylamide herbicides and fungicides
Appl. Microbiol.
26
709-718
1973
Lysinibacillus sphaericus
brenda
Khanna, P.; Kaur, S.; Sanwal, G.G.; Ali, B.
Characteristics of a cytosolic arylacylamidase metabolizing thiacetazone
J. Pharmacol. Exp. Ther.
262
1225-1231
1991
Felis catus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Jun, C.J.; Matsunaka, S.
The propanil hydrolyzing enzyme aryl acylamidase in the wild rices of genus Oryza
Pestic. Biochem. Physiol.
38
26-33
1990
Oryza alta, Oryza australiensis, Oryza barthii, Oryza collina, Oryza eichingeri, Oryza glaberrima, Oryza grandiglumis, Oryza meyeriana var. granulata, Oryza latifolia, Oryza longiglumis, Oryza longistaminata, Oryza malabarensis, Oryza minuta, Oryza officinalis, Oryza punctata, Oryza ridleyi, Oryza rufipogon, Oryza sativa, Oryza coarctata
-
brenda
Hoagland, R.E.; Zablotowicz, R.M.
Rhizobacteria with exceptionally high aryl acylamidase activity
Pestic. Biochem. Physiol.
52
190-200
1995
Pseudomonas sp., Pseudomonas sp. RA2
-
brenda
Weitnauer, E.; Robitzki, A.; Layer, P.G.
Aryl acylamidase activity exhibited by butyrylcholinesterase is higher in chick than in horse, but much lower than in fetal calf serum
Neurosci. Lett.
254
153-156
1998
Gallus gallus, Equus caballus
brenda
Fukuda, K.; Matsumoto, T.; Hagiwara, K.; Fujimoto, Z.; Mizuno, H.
Crystallization and preliminary X-ray diffraction studies of turnip aryl acylamidase: a key enzyme in plant herbicide detoxification
Acta Crystallogr. Sect. D
53
342-344
1997
Tulipa gesneriana
brenda
Costagli, C.; Galli, A.
Inhibition of cholinesterase-associated aryl acylamidase activity by anticholinesterase agents: focus on drugs potentially effective in Alzheimer's disease
Biochem. Pharmacol.
55
1733-1737
1998
Electrophorus electricus, Equus caballus
brenda
Vaughan, P.A.; Hall, G.F.; Best, D.J.
Aryl acylamidase from Rhodococcus erythropolis NCIB 12273
Appl. Microbiol. Biotechnol.
34
42-46
1990
Rhodococcus erythropolis
brenda
Checler, F.; Grassi, J.; Vincent, J.P.
Cholinesterases display genuine arylamidase activity but are totally devoid of intrinsic peptidase activities
J. Neurochem.
62
756-763
1994
Electrophorus electricus
brenda
Jayanthi, L.D.; Balasubramanian, N.; Balasubramanian, A.S.
Cholinesterases exhibiting aryl acylamidase activity in human amniotic fluid
Clin. Chim. Acta
205
157-166
1992
Homo sapiens
brenda
Stein, R.L.
Enzymatic hydrolysis of p-nitroacetanilide: mechanistic studies of the aryl acylamidase from Pseudomonas fluorescens
Biochemistry
41
991-1000
2002
Pseudomonas fluorescens
brenda
Manoharan, I.; Boopathy, R.
Diisopropylfluorophosphate-sensitive aryl acylamidase activity of fatty acid free human serum albumin
Arch. Biochem. Biophys.
452
186-188
2006
Homo sapiens
brenda
Darvesh, S.; McDonald, R.S.; Darvesh, K.V.; Mataija, D.; Mothana, S.; Cook, H.; Carneiro, K.M.; Richard, N.; Walsh, R.; Martin, E.
On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases
Bioorg. Med. Chem.
14
4586-4599
2006
Homo sapiens, Pseudomonas fluorescens
brenda
Allebrandt, K.V.; Rajesh, V.; Layer, P.G.
Expression of acetylcholinesterase (AChE) and aryl acylamidase (AAA) during early zebrafish embryogenesis
Chem. Biol. Interact.
157-158
353-355
2005
Danio rerio
brenda
Boopathy, R.; Layer, P.G.
Aryl acylamidase activity on acetylcholinesterase is high during early chicken brain development
Protein J.
23
325-333
2004
Gallus gallus
brenda
Peterson, M.E.; Daniel, R.M.; Danson, M.J.; Eisenthal, R.
The dependence of enzyme activity on temperature: determination and validation of parameters. [Erratum to document cited in CA146:333035]
Biochem. J.
403
615
2007
Pseudomonas fluorescens
brenda
Montenegro, M.F.; Moral-Naranjo, M.T.; de la Cadena, M.P.; Campoy, F.J.; Munoz-Delgado, E.; Vidal, C.J.
Human butyrylcholinesterase components differ in aryl acylamidase activity
Biol. Chem.
389
425-432
2008
Homo sapiens
brenda
Montenegro, M.F.; Moral-Naranjo, M.T.; Paez de la Cadena, M.; Campoy, F.J.; Munoz-Delgado, E.; Vidal, C.J.
The level of aryl acylamidase activity displayed by human butyrylcholinesterase depends on its molecular distribution
Chem. Biol. Interact.
175
336-339
2008
Homo sapiens
brenda
Boopathy, R.; Rajesh, R.V.; Darvesh, S.; Layer, P.G.
Human serum cholinesterase from liver pathological samples exhibit highly elevated aryl acylamidase activity
Clin. Chim. Acta
380
151-156
2007
Homo sapiens
brenda
Masson, P.; Froment, M.T.; Darvesh, S.; Schopfer, L.M.; Lockridge, O.
Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate
J. Enzyme Inhib. Med. Chem.
22
463-469
2007
Homo sapiens
brenda
Heumann, S.; Eberl, A.; Fischer-Colbrie, G.; Pobeheim, H.; Kaufmann, F.; Ribitsch, D.; Cavaco-Paulo, A.; Guebitz, G.M.
A novel aryl acylamidase from Nocardia farcinica hydrolyses polyamide
Biotechnol. Bioeng.
102
1003-1011
2009
Nocardia farcinica
brenda
Li, B.; Nachon, F.; Froment, M.T.; Verdier, L.; Debouzy, J.C.; Brasme, B.; Gillon, E.; Schopfer, L.M.; Lockridge, O.; Masson, P.
Binding and hydrolysis of soman by human serum albumin
Chem. Res. Toxicol.
21
421-431
2008
Homo sapiens
brenda
Masson, P.; Froment, M.T.; Gillon, E.; Nachon, F.; Lockridge, O.; Schopfer, L.M.
Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters
FEBS J.
275
2617-2631
2008
Homo sapiens
brenda
Montenegro, M.F.; Moral-Naranjo, M.T.; Munoz-Delgado, E.; Campoy, F.J.; Vidal, C.J.
Hydrolysis of acetylthiocoline, o-nitroacetanilide and o-nitrotrifluoroacetanilide by fetal bovine serum acetylcholinesterase
FEBS J.
276
2074-2083
2009
Bos taurus
brenda
Rajesh, R.V.; Chitra, L.; Layer, P.G.; Boopathy, R.
The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain
Biochimie
91
1087-1094
2009
Gallus gallus
brenda
Rajesh, R.V.; Layer, P.G.; Boopathy, R.
High aryl acylamidase activity associated with cobra venom acetylcholinesterase: biological significance
Biochimie
91
1450-1456
2009
Echis carinatus, Naja oxiana, Daboia russelii, Bungarus
brenda
Ko, H.J.; Lee, E.W.; Bang, W.G.; Lee, C.K.; Kim, K.H.; Choi, I.G.
Molecular characterization of a novel bacterial aryl acylamidase belonging to the amidase signature enzyme family
Mol. Cells
29
485-492
2010
bacterium CSBL00001 (C3UWD1)
brenda
Shen, W.; Chen, H.; Jia, K.; Ni, J.; Yan, X.; Li, S.
Cloning and characterization of a novel amidase from Paracoccus sp. M-1, showing aryl acylamidase and acyl transferase activities
Appl. Microbiol. Biotechnol.
94
1007-1018
2012
Paracoccus sp. M1-1 (F6N111)
brenda
Acero, E.; Ribitsch, D.; Rodriguez, R.; Dellacher, A.; Zitzenbacher, S.; Marold, A.; Greimel, K.; Schroeder, M.; Kandelbauer, A.; Heumann, S.; Nyanhongo, G.; Schwab, H.; Guebitz, G.
Two-step enzymatic functionalisation of polyamide with phenolics
J. Mol. Catal. B
79
54-60
2012
Nocardia farcinica, Nocardia farcinica IFM 10152
-
brenda
Ma, Y.; Xu, W.; Zhang, J.; Zhang, S.; Hong, K.; Deng, Z.; Sun, Y.
Nitrilase superfamily aryl acylamidase from the halotolerant mangrove Streptomyces sp. 211726
Appl. Microbiol. Biotechnol.
98
8583-8590
2014
Streptomyces sp. (A0A088BHP3), Streptomyces sp. 211726 (A0A088BHP3)
brenda
Chinnadurai, R.K.; Saravanaraman, P.; Boopathy, R.
Understanding the molecular mechanism of aryl acylamidase activity of acetylcholinesterase - An in silico study
Arch. Biochem. Biophys.
580
1-13
2015
Homo sapiens (P22303)
brenda
Lee, S.; Park, E.H.; Ko, H.J.; Bang, W.G.; Kim, H.Y.; Kim, K.H.; Choi, I.G.
Crystal structure analysis of a bacterial aryl acylamidase belonging to the amidase signature enzyme family
Biochem. Biophys. Res. Commun.
467
268-274
2015
bacterium CSBL00001 (C3UWD1)
brenda
Chinnadurai, R.K.; Saravanaraman, P.; Boopathy, R.
The significance of aryl acylamidase activity of acetylcholinesterase in osteoblast differentiation and mineralization
Mol. Cell. Biochem.
440
199-208
2018
Homo sapiens (P22303)
brenda