Information on EC 3.5.1.111 - 2-oxoglutaramate amidase

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The expected taxonomic range for this enzyme is: Paenarthrobacter nicotinovorans

EC NUMBER
COMMENTARY hide
3.5.1.111
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RECOMMENDED NAME
GeneOntology No.
2-oxoglutaramate amidase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-oxoglutaramate + H2O = 2-oxoglutarate + NH3
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Alanine, aspartate and glutamate metabolism
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nicotine degradation I (pyridine pathway)
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S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation
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SYSTEMATIC NAME
IUBMB Comments
5-amino-2,5-dioxopentanoate amidohydrolase
The enzyme, which is highly specific for its substrate, participates in the nicotine degradation pathway of several Gram-positive bacteria.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-oxoglutaramate + H2O
?
show the reaction diagram
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-
?
L-glutamic acid + H2O
?
show the reaction diagram
poor substrate
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-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.3
2-Oxoglutaramate
pH 7.1, 30 °C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
194
2-Oxoglutaramate
Paenarthrobacter nicotinovorans
Q93NG1
pH 7.1, 30 °C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
32300
calculated from cDNA
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homotetramer
4 * 32300, gel filtration
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
Show AA Sequence (200 entries)
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