Any feedback?
Information on EC 3.5.1.108 - UDP-3-O-acyl-N-acetylglucosamine deacetylase and Organism(s) Pseudomonas aeruginosa and UniProt Accession P47205
for references in articles please use BRENDA:EC3.5.1.108Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
3.5.1.108 UDP-3-O-acyl-N-acetylglucosamine deacetylaseIUBMB Comments
A zinc protein. The enzyme catalyses a committed step in the biosynthesis of lipid A.
Specify your search results
Word Map
- 3.5.1.108
- histone
- sirt1
-
deacetylation
- sirtuins
-
nad+-dependent
- chromatin
- hdacs
- nicotinamide
- acetyltransferase
- resveratrol
- nad+
- nucleosome
-
trichostatin
- repressor
-
longevity
-
lifespan
-
hyperacetylation
-
corepressors
-
calorie
-
coactivator
-
sirt1-mediated
- tubulin
-
forkhead
-
non-histone
-
proliferator-activated
-
hydroxamic
- panobinostat
- microtubule
- heterochromatin
- pgc-1alpha
-
foxos
- phenacetin
- mef2
-
deacylase
-
suberoylanilide
- romidepsin
-
aggresome
- sirtinol
-
sirt1-dependent
- synthesis
-
pan-hdac
- cortactin
- pharmacology
- medicine
- drug development
-
chromodomain
-
chromatin-remodeling
-
ubiquitin-binding
- saha
- nampt
- vorinostat
- paraoxon
-
dinucleotide-dependent
-
chromatin-modifying
The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
+
=
+
+
=
a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine
+
Synonyms
deacetylase, udp-3-o-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylase, lpxc enzyme, deacetylase lpxc, udp-3-o-acyl-n-acetylglucosamine deacetylase, enva protein, udp-3-o-[(r)-3-hydroxymyristoyl]-n-acetylglucosamine deacetylase, udp-3-o-[r-3-hydroxymyristoyl]-glcnac deacetylase, udp-3-o-(r-3-hydroxyacyl)-n-acetylglucosamine deacetylase, lpxc protein, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
-
UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase
-
deacetylase LpxC
LpxC deacetylase
-
-
-
-
LpxC enzyme
-
-
-
-
LpxC protein
-
-
-
-
UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase
-
-
-
-
UDP-(3-O-acyl)-N-acetylglucosamine deacetylase
-
-
-
-
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
-
-
-
-
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
-
-
-
-
UDP-3-O-acyl-GlcNAc deacetylase
-
-
-
-
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetylglucosamine amidohydrolase
-
-
-
-
deacetylase LpxC
-
-
-
-
PATHWAY SOURCE
PATHWAYS
BRENDA
-
-, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine amidohydrolase
A zinc protein. The enzyme catalyses a committed step in the biosynthesis of lipid A.
CAS REGISTRY NUMBER
COMMENTARY
157971-99-8
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
UDP-3-O-[(1-hexanoylamino)-1-oxopropan-2-yl]-N-acetyl-alpha-D-glucosamine + H2O
UDP-3-O-[(1-hexanoylamino)-1-oxopropan-2-yl]-alpha-D-glucosamine + acetate
-
-
-
?
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate
-
-
-
?
UDP-N-acetylglucosamine + H2O
UDP-D-glucosamine + acetate
-
-
-
?
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
UDP-3-O-[(3R)-3-hydroxydecanoyl]-N-acetyl-alpha-D-glucosamine + H2O
UDP-3-O-[(3R)-3-hydroxydecanoyl]-alpha-D-glucosamine + acetate
-
-
-
-
?
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
-
-
?
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
a committed step of lipopolysaccharide biosynthesis
-
-
?
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
-
-
-
?
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
by placing the lpxC gene of Pseudomonas aeruginosa under tight control of an arabinose-inducible promoter, the essentiality of LpxC activity for Pseudomonas aeruginosa is demonstrated
-
-
?
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate
-
-
-
-
?
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate
-
-
-
-
r
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate
-
first committed step in the biosynthesis of lipid A
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
a committed step of lipopolysaccharide biosynthesis
-
-
?
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
-
by placing the lpxC gene of Pseudomonas aeruginosa under tight control of an arabinose-inducible promoter, the essentiality of LpxC activity for Pseudomonas aeruginosa is demonstrated
-
-
?
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate
-
-
-
-
r
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate
-
first committed step in the biosynthesis of lipid A
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Zn2+
additional information
Zn2+
zinc-dependent metalloamidase, binding structure analysis from crystal structure
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(2R)-4-(2'-ethyl[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(2'-fluoro[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
-
(2R)-4-(3'-chloro[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(3-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(4'-cyano[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(4'-fluoro[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(4-cyclohexyl-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(4-tert-butyl-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[3-(2,3-difluorophenyl)-1,2-oxazol-5-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[3-(2-fluoro-3-methoxyphenyl)-1,2-oxazol-5-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[3-(2-fluoro-4-methoxyphenyl)-1,2-oxazol-5-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4'-(3-aminopropoxy)[1,1'-biphenyl]-4-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4'-(3-carbamimidamidopropoxy)[1,1'-biphenyl]-4-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4'-(aminomethyl)[1,1'-biphenyl]-4-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2,3-dichlorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2,5-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2,6-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2-fluoro-3-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
-
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2H-1,3-benzodioxol-5-yl)phenyl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(3,4-dichlorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(3,4-difluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(3,5-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(3,5-dimethylphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(3-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(3-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(4-chloro-2,3-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(4-chloro-2-fluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(4-chloro-2-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(4-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(benzyloxy)phenyl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(cyclohex-1-en-1-yl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(cyclopentyloxy)phenyl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[5-(2,3-dichlorophenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[5-(2-fluoro-4-methoxyphenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[5-(2-fluorophenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[5-(3-fluorophenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(1-phenyl-1H-pyrazol-4-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2'-oxo[2,4'-bipyridin]-1'(2'H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo[4,4'-bipyridin]-1(2H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(3-phenyl-1,2-oxazol-5-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-oxo-7-phenylquinazolin-3(4H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-phenyl-1H-1,2,3-triazol-1-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-phenyl-1H-pyrazol-1-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(5-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(5-phenyl-1,2-oxazol-3-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(5-phenylpyridin-2-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(6-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(6-oxo-4-phenylpyrimidin-1(6H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(6-phenylpyridin-3-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-(2,3,4-trifluorophenyl)pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-(2-phenylethyl)pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-(phenylethynyl)pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[(E)-2-phenylethenyl]pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(1,3-thiazol-2-yl)phenyl]pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(pyridin-2-yl)phenyl]pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(pyridin-4-yl)phenyl]pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[3'-(1H-pyrazol-1-yl)[1,1'-biphenyl]-4-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[3'-(propan-2-yl)[1,1'-biphenyl]-4-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[3-(4-methylphenyl)-1,2-oxazol-5-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(4-methylphenyl)-1H-1,2,3-triazol-1-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(naphthalen-2-yl)-2-oxopyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(phenylsulfanyl)phenyl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(pyridin-3-yl)phenyl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-[(pyridin-4-yl)oxy]phenyl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-[4-(1,2-oxazol-3-yl)phenyl]-2-oxopyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-(2'-methoxy[1,1'-biphenyl]-4-yl)-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-(6-methoxy-2'-oxo[3,4'-bipyridin]-1'(2'H)-yl)-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-(2-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-(3-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-[4-(2-methoxypyrimidin-5-yl)phenyl]-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-[4-(5-methoxypyrimidin-2-yl)phenyl]-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
-
(2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide
potent inhibitor, shows antibacterial activity against a wide range of Gram-negative pathogens, binding mode
(2R)-N-hydroxy-4-(2-hydroxy-6-phenylpyridin-3-yl)-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-N-hydroxy-4-[4'-(hydroxyacetyl)[1,1'-biphenyl]-4-yl]-2-(methanesulfonyl)-2-methylbutanamide
-
(2S,3R)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1,2-oxazol-5-yl)propanamide
-
(2S,3R)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1,3-oxazol-2-yl)propanamide
-
(2S,3R)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylbutanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-5-ethoxy-N,3-dihydroxy-2-methylpentanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2,4-dimethylpentanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1,2-oxazol-3-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1-methyl-1H-1,2,3-triazol-5-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1-methyl-1H-imidazol-2-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1H-pyrazol-5-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(5-methyl-1,2-oxazol-3-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(pyridin-2-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(pyridin-3-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-phenylpropanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylbutanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylheptanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylpentanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-3-(1H-imidazol-5-yl)-2-methylpropanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-3-[5-(hydroxymethyl)-1,2-oxazol-3-yl]-2-methylpropanamide
-
(4R)-2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(3-fluoro-4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(3-fluoro-4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-acetylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-bromophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-butylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[3-chloro-4-(trifluoromethoxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[3-fluoro-4-[(prop-2-en-1-yl)oxy]phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[4-(dimethylamino)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[4-[(3-fluorophenyl)methoxy]-3-(trifluoromethoxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[4-[(but-3-en-1-yl)oxy]-3-(trifluoromethoxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[4-[(but-3-en-1-yl)oxy]phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[4-[(but-3-en-1-yl)oxy]phenyl]-N-hydroxy-4,5-dihydro-1,3-thiazole-4-carboxamide
-
(4R)-2-[5-fluoro-4-methoxy-2-methyl-3-(prop-2-en-1-yl)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-(4'-propyl[1,1'-biphenyl]-4-yl)-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-(4-iodophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-(4-methylphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-(4-methylphenyl)-4,5-dihydro-1,3-thiazole-4-carboxamide
-
(4R)-N-hydroxy-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-methoxy-3,5-bis(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-thiazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-methoxy-3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-[(3-methylbut-2-en-1-yl)oxy]-3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-[(3-nitrophenoxy)methyl]phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-[(3-nitrophenyl)methoxy]phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-[(prop-2-en-1-yl)oxy]-3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-[(prop-2-en-1-yl)oxy]-3-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[6-(trifluoromethyl)pyridin-3-yl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-[(3S)-3-hydroxyhexadecanoyl]-D-glucitol
-
1,5-anhydro-2-deoxy-3-O-hexanoyl-2-[[hydroxy(methyl)phosphoryl]methyl]-D-glucitol
-
1-benzyl-N-hydroxy-4-[4-(phenylethynyl)benzamido]piperidine-4-carboxamide
-
1-hydroxy-4-[4-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl]phenoxy]pyridin-1-ium
-
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-thiazole-4-carboxamide
-
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
-
2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylpropanamide
-
2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
-
2-[[([1,1'-biphenyl]-4-yl)oxy]methyl]-N,3-dihydroxy-2-methylpropanamide
-
3-([1,1'-biphenyl]-4-sulfonyl)-N-hydroxy-2-(methanesulfonyl)-2-methylpropanamide
-
3-ethoxy-4-fluoro-N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]benzamide
-
3-[([1,1'-biphenyl]-4-yl)oxy]-N-hydroxy-2-(methanesulfonyl)-2-methylpropanamide
-
3-[([1,1'-biphenyl]-4-yl)sulfanyl]-N-hydroxy-2-(methanesulfonyl)-2-methylpropanamide
-
4'-ethyl-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl][1,1'-biphenyl]-4-carboxamide
-
4'-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl][1,1'-biphenyl]-3-carboxamide
-
4'-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl][1,1'-biphenyl]-4-carboxylic acid
-
4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(hydroxymethyl)-2-methylbutanamide
-
4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)butanamide
-
4-([4'-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl][1,1'-biphenyl]-4-yl]oxy)butanoic acid
-
4-([4-[(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl]phenyl)ethynyl]phenoxy]methyl)-N-hydroxyoxane-4-carboxamide
-
4-([[4-(4-chlorophenoxy)phenyl]sulfanyl]methyl)-N-hydroxyoxane-4-carboxamide
-
4-[(4-[[4-([2-[(dimethylamino)methyl]morpholin-4-yl]methyl)phenyl]ethynyl]phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
-
4-[(but-3-en-1-yl)oxy]-N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]benzamide
-
4-[[([1,1'-biphenyl]-4-yl)oxy]methyl]-N-hydroxyoxane-4-carboxamide
-
4-[[4-(benzyloxy)phenoxy]methyl]-N-hydroxyoxane-4-carboxamide
-
4-[[4-([4-[(4-acetylpiperazin-1-yl)methyl]phenyl]ethynyl)phenoxy]methyl]-N-hydroxyoxane-4-carboxamide
-
6-(1H-benzimidazol-1-yl)-N-hydroxy-5-[4-([6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]ethynyl)phenyl]pyridine-3-carboxamide
crystal structure of inhibitor B bound to the enzyme
EDTA
0.002 mM, complete inactivation, reactivated by the addition of excess heavy metal
N-hydroxy-1,1-dioxo-4-[4-(phenylethynyl)benzamido]-1lambda6-thiane-4-carboxamide
-
N-hydroxy-2-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-thiazole-4-carboxamide
-
N-hydroxy-4-([4-[(4-[[4-(propan-2-yl)piperazin-1-yl]methyl]phenyl)ethynyl]phenoxy]methyl)oxane-4-carboxamide
-
N-hydroxy-4-([[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]sulfanyl]methyl)oxane-4-carboxamide
-
N-hydroxy-4-methoxy-1-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenoxy]methyl]cyclohexane-1-carboxamide
-
N-hydroxy-4-[(4-[[4-([4-[2-(1H-imidazol-1-yl)ethyl]piperazin-1-yl]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-[[4-([4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-[[4-([4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-[[4-([[(4-methoxyphenyl)methyl]amino]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[4-(phenylethynyl)benzamido]piperidine-4-carboxamide
-
N-hydroxy-4-[[4-(4-phenylbuta-1,3-diyn-1-yl)phenoxy]methyl]oxane-4-carboxamide
-
N-hydroxy-4-[[4-(5-hydroxy-5-methylhexa-1,3-diyn-1-yl)phenoxy]methyl]oxane-4-carboxamide
-
N-hydroxy-4-[[4-([4-[(4-methylpiperazin-1-yl)methyl]phenyl]ethynyl)phenoxy]methyl]oxane-4-carboxamide
-
N-hydroxy-4-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzene-1-sulfinyl]methyl]oxane-4-carboxamide
-
N-hydroxy-4-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenoxy]methyl]oxane-4-carboxamide
-
N-hydroxy-6-(1H-imidazol-1-yl)-5-[4-([6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]ethynyl)phenyl]pyridine-3-carboxamide
-
N-[(1R)-2-(hydroxyamino)-2-oxo-1-phenylethyl]-4-(phenylethynyl)benzamide
-
N-[(1S)-2-(hydroxyamino)-2-oxo-1-phenylethyl]-4-(phenylethynyl)benzamide
-
N-[(2R)-1-(hydroxyamino)-3-(methanesulfonyl)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[(2R)-1-(hydroxyamino)-3-(methylsulfanyl)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-1H-indazole-3-carboxamide
-
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(trifluoromethoxy)benzamide
-
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-[(prop-2-en-1-yl)oxy]-3-(trifluoromethoxy)benzamide
-
N-[(2S)-3-amino-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[(2S)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(phenylethynyl)benzamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-([6-[(morpholin-4-yl)methyl]pyridin-3-yl]ethynyl)benzamide
-
N-[1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[1-(hydroxyamino)-2-methyl-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-(phenylethynyl)benzamide
-
N-[1-(hydroxycarbamoyl)cyclobutyl]-4-(phenylethynyl)benzamide
-
N-[1-(hydroxycarbamoyl)cyclohexyl]-4-(phenylethynyl)benzamide
-
N-[3-hydroxy-1-(hydroxyamino)-2-methyl-1-oxopropan-2-yl][1,1'-biphenyl]-4-carboxamide
-
N1-hydroxy-N2-[4-(phenylethynyl)benzoyl]-N4-prop-2-yn-1-yl-L-aspartamide
-
N1-hydroxy-N4-(2-methoxyethyl)-N2-[4-(phenylethynyl)benzoyl]-L-aspartamide
-
N1-hydroxy-N4-(3-hydroxypropyl)-N2-[4-(phenylethynyl)benzoyl]-L-aspartamide
-
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
-
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
-
-
(R)-(hydroxyamino)((R)-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazol-4-yl)methanol
-
-
(R)-2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-isopropyl-4-oxobutanamide
-
-
(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-methyl-4-oxobutanamide
-
-
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
-
-
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
-
-
(R)-N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
(S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide
-
-
(S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-methyl-4,5-dihydroisoxazole-5-carboxamide
-
-
(S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-methyl-4-oxobutanamide
-
-
2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3,4-bis(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)-N-hydroxyacetamide
-
-
2-(3-allyl-5-fluoro-4-methoxy-2-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-chloro-4-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-fluoro-4-(2-(trifluoromethyl)benzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-fluoro-4-(3-(trifluoromethyl)benzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-fluoro-4-(3-methylbenzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(allyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(allyloxy)-3-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(but-3-enyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
-
-
2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(heptyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-acetamidophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-acetylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-butylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
-
-
2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
-
-
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide
-
-
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid
-
-
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide
-
-
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-methyl-4,5-dihydroisoxazole-5-carboxamide
-
-
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-propyl-4,5-dihydroisoxazole-5-carboxamide
-
-
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-N-methyl-4,5-dihydroisoxazole-5-carboxamide
-
-
3-ethoxy-4-fluoro-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
-
-
4-(allyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-3-(trifluoromethoxy)benzamide
-
-
4-(but-3-enyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
-
-
4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide
-
-
4-({4-[(4-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl}phenyl)ethynyl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide
-
-
4-({[4-(4-chlorophenoxy)phenyl]sulfanyl}methyl)-N-hydroxyoxane-4-carboxamide
-
-
4-fluoro-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
-
-
4-[(4-{2-[(dimethylamino)methyl]morpholin-4-yl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
-
-
4-[(4-{[4-({2-[(dimethylamino)methyl]morpholin-4-yl}methyl)phenyl]ethynyl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
-
-
4-{[4-(4-acetylpiperazin-1-yl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide
-
-
4-{[4-({4-[(4-acetylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide
-
-
N,4-dihydroxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide
-
-
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
-
-
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-(trifluoromethoxy)benzamide
-
-
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
-
-
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methylbenzamide
-
-
N-hydroxy-2-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(2-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(3-propyl-4,5-bis(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4'-propylbiphenyl-4-yl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-(3-methylbut-2-enyloxy)-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrothiazole-4-carboxamide
-
-
N-hydroxy-2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazole-4-carboxamide
-
-
N-hydroxy-2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxamide
-
-
N-hydroxy-2-(6-(trifluoromethyl)pyridin-3-yl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-p-tolyl-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide
-
-
N-hydroxy-4-({4-[(4-{[4-(propan-2-yl)piperazin-1-yl]methyl}phenyl)ethynyl]phenoxy}methyl)oxane-4-carboxamide
-
-
N-hydroxy-4-({4-[4-(propan-2-yl)piperazin-1-yl]phenoxy}methyl)oxane-4-carboxamide
-
-
N-hydroxy-4-({[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenyl]sulfanyl}methyl)oxane-4-carboxamide
-
-
N-hydroxy-4-methoxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide
-
-
N-hydroxy-4-[(4-{4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{[4-({4-[2-(1H-imidazol-1-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{[4-({[(4-methoxyphenyl)methyl]amino}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-{[4-({4-[(4-methylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide
-
-
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzene-1-sulfinyl]methyl}oxane-4-carboxamide
-
-
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide
-
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide
-
-
additional information
study the potentially important structural differences in active sites of both proteins responsible for making the inhibitors selective for Escherichia coli as compared to Pseudomonas aeruginosa LpxC, homology models of the LpxC of both organisms are developed and validated on the basis of a 3D profile and PROCHECK. Subsequently, a molecular electrostatic potential (MEP)-based surface and cavity-depth analysis is performed. Finally, a cross-docking analysis of reported inhibitors is performed to reveal selective binding modes. These studies identify differences between the two active sites and have implications for designing effective strategies to identify LpxC inhibitors that can be developed as novel broad-spectrum antibacterial drugs
-
additional information
-
study the potentially important structural differences in active sites of both proteins responsible for making the inhibitors selective for Escherichia coli as compared to Pseudomonas aeruginosa LpxC, homology models of the LpxC of both organisms are developed and validated on the basis of a 3D profile and PROCHECK. Subsequently, a molecular electrostatic potential (MEP)-based surface and cavity-depth analysis is performed. Finally, a cross-docking analysis of reported inhibitors is performed to reveal selective binding modes. These studies identify differences between the two active sites and have implications for designing effective strategies to identify LpxC inhibitors that can be developed as novel broad-spectrum antibacterial drugs
-
additional information
structure-based drug design, inhibitor binding structures, overview
-
additional information
-
structure-based drug design, inhibitor binding structures, overview
-
additional information
-
(4R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide is active against a Pseudomonas aeruginosa construct in which the endogenous lpxC gene is inactivated and in which LpxC activity is supplied by the lpxC gene from Escherichia coli. An Escherichia coli construct in which growth is dependent on the Pseudomonas aeruginosa lpxC gene is resistant to the compound
-
additional information
-
evaluation of LpxC inhibitors that are potent and rapidly bactericidal against multiple Gram-negative species, overview
-
additional information
-
synthesis, structure, structure-activity relationship, and inhibitory potencies of tetrahydropyran-based LpxC inhibitors, overview
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0000261
(2R)-4-(2'-ethyl[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000136
(2R)-4-(2'-fluoro[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
-
0.00000354
(2R)-4-(3'-chloro[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000049
(2R)-4-(3-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000064
(2R)-4-(4'-cyano[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000174
(2R)-4-(4'-fluoro[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000011
(2R)-4-(4-cyclohexyl-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000069
(2R)-4-(4-tert-butyl-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000023
(2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000137
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000681
(2R)-4-[3-(2,3-difluorophenyl)-1,2-oxazol-5-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000532
(2R)-4-[3-(2-fluoro-3-methoxyphenyl)-1,2-oxazol-5-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000044
(2R)-4-[3-(2-fluoro-4-methoxyphenyl)-1,2-oxazol-5-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000127
(2R)-4-[4'-(3-aminopropoxy)[1,1'-biphenyl]-4-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000949
(2R)-4-[4'-(3-carbamimidamidopropoxy)[1,1'-biphenyl]-4-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000129
(2R)-4-[4'-(aminomethyl)[1,1'-biphenyl]-4-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000195
(2R)-4-[4-(2,3-dichlorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000808
(2R)-4-[4-(2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000044
(2R)-4-[4-(2,5-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000048
(2R)-4-[4-(2,6-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000471
(2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000018
(2R)-4-[4-(2-fluoro-3-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000012
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
-
0.0000011
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000022
(2R)-4-[4-(2-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000012
(2R)-4-[4-(2H-1,3-benzodioxol-5-yl)phenyl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000167
(2R)-4-[4-(3,4-dichlorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000187
(2R)-4-[4-(3,4-difluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000039
(2R)-4-[4-(3,5-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000053
(2R)-4-[4-(3,5-dimethylphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000002
(2R)-4-[4-(3-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000003
(2R)-4-[4-(3-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000052
(2R)-4-[4-(4-chloro-2,3-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000000657
(2R)-4-[4-(4-chloro-2-fluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000011
(2R)-4-[4-(4-chloro-2-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000000912
(2R)-4-[4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000029
(2R)-4-[4-(4-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000516
(2R)-4-[4-(benzyloxy)phenyl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000041
(2R)-4-[4-(cyclohex-1-en-1-yl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000101
(2R)-4-[4-(cyclopentyloxy)phenyl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000266
(2R)-4-[5-(2,3-dichlorophenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000232
(2R)-4-[5-(2-fluoro-4-methoxyphenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000831
(2R)-4-[5-(2-fluorophenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000675
(2R)-4-[5-(3-fluorophenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000003
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000135
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(1-phenyl-1H-pyrazol-4-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00006
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2'-oxo[2,4'-bipyridin]-1'(2'H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000036
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000057
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000039
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo[4,4'-bipyridin]-1(2H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000067
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000302
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(3-phenyl-1,2-oxazol-5-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000023
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-oxo-7-phenylquinazolin-3(4H)-yl)butanamide
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.00000085
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-phenyl-1H-1,2,3-triazol-1-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000161
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-phenyl-1H-pyrazol-1-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00003
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(5-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000000511
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(5-phenyl-1,2-oxazol-3-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000013
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(5-phenylpyridin-2-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000022
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(6-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000085
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(6-oxo-4-phenylpyrimidin-1(6H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000049
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(6-phenylpyridin-3-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000015
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-(2,3,4-trifluorophenyl)pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000006
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-(2-phenylethyl)pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000018
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-(phenylethynyl)pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000032
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[(E)-2-phenylethenyl]pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000011
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(1,3-thiazol-2-yl)phenyl]pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000053
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000013
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(pyridin-2-yl)phenyl]pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000012
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(pyridin-4-yl)phenyl]pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000221
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[3'-(1H-pyrazol-1-yl)[1,1'-biphenyl]-4-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000678
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[3'-(propan-2-yl)[1,1'-biphenyl]-4-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000293
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[3-(4-methylphenyl)-1,2-oxazol-5-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000139
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(4-methylphenyl)-1H-1,2,3-triazol-1-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000012
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(naphthalen-2-yl)-2-oxopyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000304
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(phenylsulfanyl)phenyl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000297
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(pyridin-3-yl)phenyl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000216
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-[(pyridin-4-yl)oxy]phenyl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000011
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-[4-(1,2-oxazol-3-yl)phenyl]-2-oxopyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000704
(2R)-N-hydroxy-2-(methanesulfonyl)-4-(2'-methoxy[1,1'-biphenyl]-4-yl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000064
(2R)-N-hydroxy-2-(methanesulfonyl)-4-(6-methoxy-2'-oxo[3,4'-bipyridin]-1'(2'H)-yl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000012
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-(2-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000037
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-(3-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000026
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000002
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-[4-(2-methoxypyrimidin-5-yl)phenyl]-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000012
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-[4-(5-methoxypyrimidin-2-yl)phenyl]-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000053
(2R)-N-hydroxy-4-(2-hydroxy-6-phenylpyridin-3-yl)-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000185
(2R)-N-hydroxy-4-[4'-(hydroxyacetyl)[1,1'-biphenyl]-4-yl]-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000044
(2S)-N1-hydroxy-2-[4-(phenylethynyl)benzamido]butanediamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000008
(2S,3R)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1,2-oxazol-5-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000003
(2S,3R)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1,3-oxazol-2-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000004
(2S,3R)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000028
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-5-ethoxy-N,3-dihydroxy-2-methylpentanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000072
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2,4-dimethylpentanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000004
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1,2-oxazol-3-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000026
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1-methyl-1H-1,2,3-triazol-5-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000025
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1-methyl-1H-imidazol-2-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000004
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1H-pyrazol-5-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000004
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(5-methyl-1,2-oxazol-3-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000015
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(pyridin-2-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000018
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(pyridin-3-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000051
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-phenylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000003
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00009
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylheptanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000008 - 0.00016
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylpentanamide
0.0000008
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-3-(1H-imidazol-5-yl)-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000006
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-3-[5-(hydroxymethyl)-1,2-oxazol-3-yl]-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.01
(4R)-2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.012
(4R)-2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0049
(4R)-2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0096
(4R)-2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0003
(4R)-2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0012
(4R)-2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0096
(4R)-2-(3-fluoro-4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00084
(4R)-2-(3-fluoro-4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.018
(4R)-2-(4-acetylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0027
(4R)-2-(4-bromophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0073
(4R)-2-(4-butylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0012
(4R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00096
(4R)-2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.006
(4R)-2-(4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0016
(4R)-2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0328
(4R)-2-[3-chloro-4-(trifluoromethoxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0014
(4R)-2-[3-fluoro-4-[(prop-2-en-1-yl)oxy]phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0049
(4R)-2-[4-(dimethylamino)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00025
(4R)-2-[4-[(3-fluorophenyl)methoxy]-3-(trifluoromethoxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00035
(4R)-2-[4-[(but-3-en-1-yl)oxy]-3-(trifluoromethoxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0056
(4R)-2-[4-[(but-3-en-1-yl)oxy]phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0587
(4R)-2-[4-[(but-3-en-1-yl)oxy]phenyl]-N-hydroxy-4,5-dihydro-1,3-thiazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0033
(4R)-2-[5-fluoro-4-methoxy-2-methyl-3-(prop-2-en-1-yl)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0055
(4R)-N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00028
(4R)-N-hydroxy-2-(4'-propyl[1,1'-biphenyl]-4-yl)-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0055
(4R)-N-hydroxy-2-(4-iodophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.02
(4R)-N-hydroxy-2-(4-methylphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0385
(4R)-N-hydroxy-2-(4-methylphenyl)-4,5-dihydro-1,3-thiazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0054
(4R)-N-hydroxy-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0078
(4R)-N-hydroxy-2-[4-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0178
(4R)-N-hydroxy-2-[4-methoxy-3,5-bis(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-thiazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00016
(4R)-N-hydroxy-2-[4-methoxy-3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0005
(4R)-N-hydroxy-2-[4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00019
(4R)-N-hydroxy-2-[4-[(3-methylbut-2-en-1-yl)oxy]-3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00056
(4R)-N-hydroxy-2-[4-[(3-nitrophenoxy)methyl]phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0013
(4R)-N-hydroxy-2-[4-[(3-nitrophenyl)methoxy]phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00012
(4R)-N-hydroxy-2-[4-[(prop-2-en-1-yl)oxy]-3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0022
(4R)-N-hydroxy-2-[4-[(prop-2-en-1-yl)oxy]-3-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.01
(4R)-N-hydroxy-2-[6-(trifluoromethyl)pyridin-3-yl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0181
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-[(3S)-3-hydroxyhexadecanoyl]-D-glucitol
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.192
1,5-anhydro-2-deoxy-3-O-hexanoyl-2-[[hydroxy(methyl)phosphoryl]methyl]-D-glucitol
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000208
1-benzyl-N-hydroxy-4-[4-(phenylethynyl)benzamido]piperidine-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000927
1-hydroxy-4-[4-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl]phenoxy]pyridin-1-ium
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0625
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-thiazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0312
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000022
2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0211
2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00039
2-[[([1,1'-biphenyl]-4-yl)oxy]methyl]-N,3-dihydroxy-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000119
3-([1,1'-biphenyl]-4-sulfonyl)-N-hydroxy-2-(methanesulfonyl)-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0476
3-ethoxy-4-fluoro-N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000314
3-[([1,1'-biphenyl]-4-yl)oxy]-N-hydroxy-2-(methanesulfonyl)-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000904
3-[([1,1'-biphenyl]-4-yl)sulfanyl]-N-hydroxy-2-(methanesulfonyl)-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000008
4'-ethyl-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl][1,1'-biphenyl]-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000278
4'-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl][1,1'-biphenyl]-3-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000736
4'-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl][1,1'-biphenyl]-4-carboxylic acid
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000033
4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(hydroxymethyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000138
4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000212
4-([4'-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl][1,1'-biphenyl]-4-yl]oxy)butanoic acid
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000026
4-([4-[(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl]phenyl)ethynyl]phenoxy]methyl)-N-hydroxyoxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000074
4-([[4-(4-chlorophenoxy)phenyl]sulfanyl]methyl)-N-hydroxyoxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000058
4-[(4-[[4-([2-[(dimethylamino)methyl]morpholin-4-yl]methyl)phenyl]ethynyl]phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0039
4-[(but-3-en-1-yl)oxy]-N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000087
4-[[([1,1'-biphenyl]-4-yl)oxy]methyl]-N-hydroxyoxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000014
4-[[4-(benzyloxy)phenoxy]methyl]-N-hydroxyoxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000003
4-[[4-([4-[(4-acetylpiperazin-1-yl)methyl]phenyl]ethynyl)phenoxy]methyl]-N-hydroxyoxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000048
6-(1H-benzimidazol-1-yl)-N-hydroxy-5-[4-([6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]ethynyl)phenyl]pyridine-3-carboxamide
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.000026
N-hydroxy-1,1-dioxo-4-[4-(phenylethynyl)benzamido]-1lambda6-thiane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0217
N-hydroxy-2-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-thiazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000075
N-hydroxy-4-([4-[(4-[[4-(propan-2-yl)piperazin-1-yl]methyl]phenyl)ethynyl]phenoxy]methyl)oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000002
N-hydroxy-4-([[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]sulfanyl]methyl)oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000086
N-hydroxy-4-methoxy-1-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenoxy]methyl]cyclohexane-1-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000092
N-hydroxy-4-[(4-phenoxyphenoxy)methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000002
N-hydroxy-4-[(4-[[4-([4-[2-(1H-imidazol-1-yl)ethyl]piperazin-1-yl]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000017
N-hydroxy-4-[(4-[[4-([4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000027
N-hydroxy-4-[(4-[[4-([4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00001
N-hydroxy-4-[(4-[[4-([[(4-methoxyphenyl)methyl]amino]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000334
N-hydroxy-4-[4-(phenylethynyl)benzamido]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.011
N-hydroxy-4-[4-(phenylethynyl)benzamido]piperidine-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000296
N-hydroxy-4-[4-(phenylethynyl)benzamido]thiane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000033
N-hydroxy-4-[[4-(4-phenylbuta-1,3-diyn-1-yl)phenoxy]methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000139
N-hydroxy-4-[[4-(5-hydroxy-5-methylhexa-1,3-diyn-1-yl)phenoxy]methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000061
N-hydroxy-4-[[4-([4-[(4-methylpiperazin-1-yl)methyl]phenyl]ethynyl)phenoxy]methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000031 - 0.0000825
N-hydroxy-4-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzene-1-sulfinyl]methyl]oxane-4-carboxamide
0.0000044
N-hydroxy-4-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenoxy]methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000064
N-hydroxy-6-(1H-imidazol-1-yl)-5-[4-([6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]ethynyl)phenyl]pyridine-3-carboxamide
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.000035
N-hydroxy-Nalpha-[4-(phenylethynyl)benzoyl]-L-histidinamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00008
N-[(1R)-2-(hydroxyamino)-2-oxo-1-phenylethyl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000074
N-[(1S)-2-(hydroxyamino)-2-oxo-1-phenylethyl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000073
N-[(2R)-1-(hydroxyamino)-3-(methanesulfonyl)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000098
N-[(2R)-1-(hydroxyamino)-3-(methylsulfanyl)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.013
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-1H-indazole-3-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000187
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00154
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0075
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-[(prop-2-en-1-yl)oxy]-3-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000028
N-[(2S)-3-amino-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000053
N-[(2S)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000002
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000063
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-([6-[(morpholin-4-yl)methyl]pyridin-3-yl]ethynyl)benzamide
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.000128
N-[1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.002067
N-[1-(hydroxyamino)-2-methyl-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000071
N-[1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0081
N-[1-(hydroxycarbamoyl)cyclobutyl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0035
N-[1-(hydroxycarbamoyl)cyclohexyl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000516
N-[2-(hydroxyamino)-2-oxoethyl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000286
N-[3-hydroxy-1-(hydroxyamino)-2-methyl-1-oxopropan-2-yl][1,1'-biphenyl]-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000014
N1-hydroxy-N2-[4-(phenylethynyl)benzoyl]-N4-prop-2-yn-1-yl-L-aspartamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000033
N1-hydroxy-N4-(2-methoxyethyl)-N2-[4-(phenylethynyl)benzoyl]-L-aspartamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000053
N1-hydroxy-N4-(3-hydroxypropyl)-N2-[4-(phenylethynyl)benzoyl]-L-aspartamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000014 - 0.0000079
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
0.0000011 - 0.0000021
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
0.0000028 - 0.0000036
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
0.0178
(R)-(hydroxyamino)((R)-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazol-4-yl)methanol
Pseudomonas aeruginosa
-
-
0.01
(R)-2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.012
(R)-2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.001
(R)-2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00025
(R)-2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0022
(R)-2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0049
(R)-2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.025
(R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0012
(R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.138
(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-isopropyl-4-oxobutanamide
Pseudomonas aeruginosa
-
-
0.00891
(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-methyl-4-oxobutanamide
Pseudomonas aeruginosa
-
-
0.013
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
Pseudomonas aeruginosa
-
-
0.0055
(R)-N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00056
(R)-N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.001
(R)-N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00016
(R)-N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0005
(R)-N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0162
(S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.0229
(S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-methyl-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.00891
(S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-methyl-4-oxobutanamide
Pseudomonas aeruginosa
-
-
0.01
2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.012
2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000162
2-(3,4-bis(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0204
2-(3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)-N-hydroxyacetamide
Pseudomonas aeruginosa
-
-
0.001 - 0.0033
2-(3-allyl-5-fluoro-4-methoxy-2-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.009 - 0.00912
2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.03 - 0.0302
2-(3-chloro-4-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0003 - 0.00159
2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0096
2-(3-fluoro-4-(2-(trifluoromethyl)benzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00084
2-(3-fluoro-4-(3-(trifluoromethyl)benzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000851
2-(3-fluoro-4-(3-methylbenzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.025 - 0.0251
2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.00025 - 0.000251
2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.00012
2-(4-(allyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0022 - 0.00223
2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0014
2-(4-(allyloxy)-3-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00035 - 0.000355
2-(4-(but-3-enyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0027
2-(4-bromophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0013 - 0.00132
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0212
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0012
2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0625
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0016
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0312
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0138
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.0162
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid
Pseudomonas aeruginosa
-
-
0.479
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.0263
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-methyl-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.00661
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-propyl-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.00427
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-N-methyl-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.046
3-ethoxy-4-fluoro-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
Pseudomonas aeruginosa
-
-
0.0148
4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4-oxobutanamide
Pseudomonas aeruginosa
-
-
0.0075 - 0.00759
4-(allyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-3-(trifluoromethoxy)benzamide
0.0039 - 0.00398
4-(but-3-enyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
0.00154
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
-
-
0.0005 - 0.000501
N-hydroxy-2-(3-propyl-4,5-bis(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
0.00056 - 0.000562
N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
0.00019
N-hydroxy-2-(4-(3-methylbut-2-enyloxy)-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.001
N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0217
N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0055
N-hydroxy-2-(4-iodophenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00016
N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0178
N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0054
N-hydroxy-2-(4-nitrophenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.01
N-hydroxy-2-(6-(trifluoromethyl)pyridin-3-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
additional information
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
0.000008
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylpentanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00016
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylpentanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000031
N-hydroxy-4-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzene-1-sulfinyl]methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000825
N-hydroxy-4-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzene-1-sulfinyl]methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000014
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
-
wild-type, pH 7.4, 37°C
0.0000079
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
-
mutant M62R, pH 7.4, 37°C
0.0000011
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
-
wild-type, pH 7.4, 37°C
0.0000021
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
-
mutant M62R, pH 7.4, 37°C
0.0000028
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
-
mutant M62R, pH 7.4, 37°C
0.0000036
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
-
wild-type, pH 7.4, 37°C
0.001
2-(3-allyl-5-fluoro-4-methoxy-2-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0033
2-(3-allyl-5-fluoro-4-methoxy-2-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0049
2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00501
2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.009
2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00912
2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.03
2-(3-chloro-4-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0302
2-(3-chloro-4-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0003
2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00159
2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.001
2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00331
2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0468
2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.025
2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0251
2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00025
2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000251
2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0022
2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00223
2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00035
2-(4-(but-3-enyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000355
2-(4-(but-3-enyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0056
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00562
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0587
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0589
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0049
2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00501
2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.018
2-(4-acetylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0182
2-(4-acetylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0073
2-(4-butylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.007413
2-(4-butylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0013
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00132
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000955
2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00096
2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.006
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00603
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0075
4-(allyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-3-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
-
-
0.00759
4-(allyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-3-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
-
-
0.0039
4-(but-3-enyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
Pseudomonas aeruginosa
-
-
0.00398
4-(but-3-enyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
Pseudomonas aeruginosa
-
-
0.0129
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
Pseudomonas aeruginosa
-
-
0.013
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
Pseudomonas aeruginosa
-
-
0.0055
N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00562
N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.006
N-hydroxy-2-(3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00603
N-hydroxy-2-(3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0025
N-hydroxy-2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00251
N-hydroxy-2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0005
N-hydroxy-2-(3-propyl-4,5-bis(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000501
N-hydroxy-2-(3-propyl-4,5-bis(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00028
N-hydroxy-2-(4'-propylbiphenyl-4-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000282
N-hydroxy-2-(4'-propylbiphenyl-4-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00056
N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000562
N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.005
N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00501
N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0078
N-hydroxy-2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00794
N-hydroxy-2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
additional information
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
-
above 50 microM
additional information
(R)-N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
above 30 microM
additional information
2-(4-(heptyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 30 microM
additional information
2-(4-acetamidophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 30 microM
additional information
4-fluoro-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
Pseudomonas aeruginosa
-
IC50 value is above 50 microM
additional information
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
-
IC50 value is above 50 microM
additional information
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methylbenzamide
Pseudomonas aeruginosa
-
IC50 value is above 50 microM
additional information
N-hydroxy-2-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 30 microM
additional information
N-hydroxy-2-(2-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 10 microM
additional information
N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 30 microM
additional information
N-hydroxy-2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 30 microM
additional information
N-hydroxy-2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 60 microM
additional information
N-hydroxy-2-p-tolyl-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 50 microM
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7 - 9
pH 7.0: about 55% of maximal activity, pH 9.0: about 75% of maximal activity
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
additional information
-
cocrystal structure of Aquifex aeolicus LpxC with bound UDP-3-O-(acyl)-glucosamine and Pseudomonas aeruginosa with bound 27b docking model, overview
metabolism
the enzyme catalyzes the first committed step of biosynthesis of lipid A
metabolism
the enzyme catalyzes the first committed step of lipid A biosynthesis
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
1.9 A resolution crystal structure of LpxC complexed with (2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide
purified recombinant truncated enzyme mutant C40S in complex with inhibitor B, sitting drop vapor diffusion method, 2 days to 4 months, X-ray diffraction structure determination and analysis at 2.06 A resolution, molecular replacement, LpxC binding to the inhibitor increases protein solubility, shortens crystallization time and leads to a high-resolution crystal structure, to reduce the amount of compound needed, an overexpression strain of Escherichia coli is created lacking acrB, a critical component of the major efflux pump
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
LpxC binding to the inhibitor increases protein solubility, shortens crystallization time and leads to a high-resolution crystal structure, to reduce the amount of compound needed, an overexpression strain of Escherichia coli is created lacking acrB, a critical component of the major efflux pump
additional information
-
LpxC binding to the inhibitor increases protein solubility, shortens crystallization time and leads to a high-resolution crystal structure, to reduce the amount of compound needed, an overexpression strain of Escherichia coli is created lacking acrB, a critical component of the major efflux pump
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant truncated enzyme mutant C40S from Escherichia coli by anion exchange and hydrophobic interaction chromatography, ultrafiltration, and gel filtration. The inhibitors remain bound to LpxC throughout purification
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene envA or lpxC, functional overexpression of the first 299 amino acids out of 303 of enzyme mutant C40S in an Escherichia coli strain BL21(DE3) pLysS, and with its inhibitors in the acrB-deficient variant strain BL21(DE3) DELTAacrB pLysS or ARC5329
subcloned the Pseudomonas aeruginosa lpxC gene into the T7-based expression vector pET11a
the paLpxC (residues 1-299, C40S) is cloned from genomic DNA by polymerase chain reaction and inserted into pPW4 expression vectors. The recombinant paLpxC is overexpressed
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
drug development
the enzyme is a target for antibiotic therapy and structure-based drug design
medicine
promising target in the development of novel antibiotics against Gram-negative bacteria
pharmacology
the enzyme is a target for antibiotic therapy and structure-based drug design
drug development
drug development
-
enzyme is an attractive target against Pseudomonas infection
drug development
-
LpxC represents a highly attractive target for a novel antibacterial drug
drug development
-
target for development of anti-infective drugs against gram-negative bacteria
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mdluli, K.E.; Witte, P.R.; Kline, T.; Barb, A.W.; Erwin, A.L.; Mansfield, B.E.; McClerren, A.L.; Pirrung, M.C.; Tumey, L.N.; Warrener, P.; Raetz, C.R.; Stover, C.K.
Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa
Antimicrob. Agents Chemother.
50
2178-2184
2006
Escherichia coli, Pseudomonas aeruginosa
Kadam, R.U.; Roy, N.
Cluster analysis and two-dimensional quantitative structure-activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors
Bioorg. Med. Chem. Lett.
16
5136-5143
2006
Pseudomonas aeruginosa
Kadam, R.U.; Chavan, A.; Roy, N.
Pharmacophoric features of Pseudomonas aeruginosa deacetylase LpxC inhibitors: an electronic and structural analysis
Bioorg. Med. Chem. Lett.
17
861-868
2007
Pseudomonas aeruginosa
Kadam, R.U.; Garg, D.; Roy, N.
Selective mapping of chemical space for Pseudomonas aeruginosa deacetylase LpxC inhibitory potential
Chem. Biol. Drug Des.
71
45-56
2008
Pseudomonas aeruginosa
Hyland, S.A.; Eveland, S.S.; Anderson, M.S.
Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathway
J. Bacteriol.
179
2029-2037
1997
Escherichia coli, Pseudomonas aeruginosa (P47205), Pseudomonas aeruginosa
Kadam, R.U.; Garg, D.; Chavan, A.; Roy, N.
Evaluation of Pseudomonas aeruginosa deacetylase LpxC inhibitory activity of dual PDE4-TNFr inhibitors: a multiscreening approach
J. Chem. Inf. Model.
47
1188-1195
2007
Pseudomonas aeruginosa
Kadam, R.U.; Shivange, A.V.; Roy, N.
Escherichia coli versus Pseudomonas aeruginosa deacetylase LpxC inhibitors selectivity: surface and cavity-depth-based analysis
J. Chem. Inf. Model.
47
1215-1224
2007
Escherichia coli, Pseudomonas aeruginosa (P47205), Pseudomonas aeruginosa
Kline, T.; Andersen, N.H.; Harwood, E.A.; Bowman, J.; Malanda, A.; Endsley, S.; Erwin, A.L.; Doyle, M.; Fong, S.; Harris, A.L.; Mendelsohn, B.; Mdluli, K.; Raetz, C.R.; Stover, C.K.; Witte, P.R.; Yabannavar, A.; Zhu, S.
Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC
J. Med. Chem.
45
3112-3129
2002
Pseudomonas aeruginosa
Mochalkin, I.; Knafels, J.D.; Lightle, S.
Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.
Protein Sci.
17
450-457
2008
Pseudomonas aeruginosa (P47205), Pseudomonas aeruginosa
Murphy-Benenato, K.; Olivier, N.; Choy, A.; Ross, P.; Miller, M.; Thresher, J.; Gao, N.; Hale, M.
Synthesis, structure, and SAR of tetrahydropyran-based LpxC inhibitors
ACS Med. Chem. Lett.
5
1213-1218A
2014
Escherichia coli, Pseudomonas aeruginosa, Aquifex aeolicus (O67648), Aquifex aeolicus, Escherichia coli W3110 / ATCC 27325
Tomaras, A.; McPherson, C.; Kuhn, M.; Carif, A.; Mullins, L.; George, D.; Desbonnet, C.; Eidem, T.; Montgomery, J.; Brown, M.; Reilly, U.; Miller, A.; O'Donnell, J.
LpxC Inhibitors as new antibacterial agents and tools for studying regulation of lipid a biosynthesis in Gram-negative pathogens
mBio
5
e01551-14
2014
Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa
Gao, N.; McLeod, S.; Hajec, L.; Olivier, N.; Lahiri, S.; Prince, D.; Thresher, J.; Ross, P.; Whiteaker, J.; Doig, P.; Li, A.; Hill, P.; Cornebise, M.; Reck, F.; Hale, M.
Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain
Protein Expr. Purif.
104
57-64
2014
Pseudomonas aeruginosa (P47205), Pseudomonas aeruginosa
Kalinin, D.V.; Holl, R.
Insights into the zinc-dependent deacetylase LpxC biochemical properties and inhibitor design
Curr. Top. Med. Chem.
16
2379-2430
2016
Aquifex aeolicus (O67648), Escherichia coli (P0A727), Pseudomonas aeruginosa (P47205), Pseudomonas aeruginosa ATCC 15692 (P47205)
Piizzi, G.; Parker, D.T.; Peng, Y.; Dobler, M.; Patnaik, A.; Wattanasin, S.; Liu, E.; Lenoir, F.; Nunez, J.; Kerrigan, J.; McKenney, D.; Osborne, C.; Yu, D.; Lanieri, L.; Bojkovic, J.; Dzink-Fox, J.; Lilly, M.D.; Sprague, E.R.; Lu, Y.; Wang, H.; Ranjitkar, S.; Xie, L.; Wang, B.; Glick, M.; Hamann, L.G.
Design, synthesis, and properties of a potent inhibitor of Pseudomonas aeruginosa deacetylase LpxC
J. Med. Chem.
60
5002-5014
2017
Pseudomonas aeruginosa
EXTERNAL LINKS (specific for EC-Number 3.5.1.108)
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
