Reference on EC 3.4.25.2 - HslU-HslV peptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Welch, R.A.; Burland, V.; Plunkett, G.III; Redford, P.; Roesch, P.; Rasko, D.; Buckles, E.L.; Liou, S.R.; Boutin, A.; Hackett, J.; Stroud, D.; Mayhew, G.F.; Rose, D.J.; Zhou, S.; Schwartz, D.C.; Perna, N.T.; Mobley, H.L.T.; Donnenberg, M.S.; Blattner, F.R.
Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli
Proc. Natl. Acad. Sci. USA
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Escherichia coli (P0A7B9)
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Nucleic Acids Res.
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Shigella flexneri (P0A7C1), Shigella flexneri 301 (P0A7C1)
Plunkett, G.3rd; Burland, V.; Daniels, D.L.; Blattner, F.R.
Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes
Nucleic Acids Res.
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1993
Escherichia coli (P0A7B8)
Perna, N.T.; Plunkett, G.; Burland, V.; Mau, B.; Glasner, J.D.; et al.
Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
Nature
409
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Escherichia coli (P0A7C0)
Hayashi, T.; Makino, K.; Ohnishi, M.; Kurokawa, K.; Ishii, K.; et al.
Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12
DNA Res.
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2001
Escherichia coli (P0A7C0)
Bochtler, M.; Ditzel, L.; Groll, M.; Huber, R.
Crystal structure of heat shock locus V (HslV) from Escherichia coli
Proc. Natl. Acad. Sci. USA
94
6070-6074
1997
Escherichia coli (P0A7B8), Escherichia coli
Bochtler, M.; Hartmann, C.; Song, H.K.; Bourenkov, G.P.; Bartunik, H.D.; Huber R.
The structures of HslU and the ATP-dependent protease HslU-HslV
Nature
403
800-805
2000
Escherichia coli (P0A7B8), Escherichia coli
Chuang, S.E.; Burland, V.; Plunkett, G.III; Daniels, D.L.; Blattner, F.R.
Sequence analysis of four new heat-shock genes constituting the hslTS/ibpAB and hslVU operons in Escherichia coli
Gene
134
1-6
1993
Escherichia coli (P0A7B8)
Yoo, S.J.; Shim, Y.K.; Seong, I.S.; Seol, J.H.; Kang, M.S.; Chung, C.H.
Mutagenesis of two N-terminal Thr and five Ser residues in HslV, the proteolytic component of the ATP-dependent HslVU protease
FEBS Lett.
412
57-60
1997
Escherichia coli (P0A7B8), Escherichia coli
Yoo, S.J.; Seol, J.H.; Shin, D.H.; Rohrwild, M.; Kang, M.S.; Tanaka, K.; Goldberg, A.L.; Chung, C.H.
Purification and characterization of the heat shock proteins HslV and HslU that form a new ATP-dependent protease in Escherichia coli
J. Biol. Chem.
271
14035-14040
1996
Escherichia coli
Yoo, S.J.; Seol, J.H.; Seong, I.S.; Kang, M.S.; Chung, C.H.
ATP binding, but not its hydrolysis, is required for assembly and proteolytic activity of the HslVU protease in Escherichia coli
Biochem. Biophys. Res. Commun.
238
581-585
1997
Escherichia coli
Bochtler, M.; Song, H.K.; Hartmann, C.; Ramachandran, R.; Huber, R.
The quaternary arrangement of HslU and HslV in a cocrystal: a response to Wang, Yale
J. Struct. Biol.
135
281-293
2001
Escherichia coli
Bogyo, M.; McMaster, J.S.; Gaczynska, M.; Tortorella, D.; Goldberg, A.L.; Ploegh, H.
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors
Proc. Natl. Acad. Sci. USA
94
6629-6634
1997
Escherichia coli
Huang, H.; Goldberg, A.L.
Proteolytic activity of the ATP-dependent protease HslVU can be uncoupled from ATP hydrolysis
J. Biol. Chem.
272
21364-21372
1997
Escherichia coli
Lee, Y.Y.; Chang, C.F.; Kuo, C.L.; Chen, M.C.; Yu, C.H.; Lin, P.I.; Wu, W.F.
Subunit oligomerization and substrate recognition of the Escherichia coli ClpYQ (HslUV) protease implicated by in vivo protein-protein interactions in the yeast two-hybrid system
J. Bacteriol.
185
2393-2401
2003
Escherichia coli
Seong, I.S.; Kang, M.S.; Choi, M.K.; Lee, J.W.; Koh, O.J.; Wang, J.; Eom, S.H.; Chung, C.H.
The C-terminal tails of HslU ATPase act as a molecular switch for activation of HslV peptidase
J. Biol. Chem.
277
25976-25982
2002
Escherichia coli
Nishii, W.; Takahashi, K.
Determination of the cleavage sites in SulA, a cell division inhibitor, by the ATP-dependent HslVU protease from Escherichia coli
FEBS Lett.
553
351-354
2003
Escherichia coli
Rohrwild, M.; Coux, O.; Huang, H.C.; Moerschell, R.P.; Yoo, S.J.; Seol, J.H.; Chung, C.H.; Goldberg, A.L.
HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome
Proc. Natl. Acad. Sci. USA
93
5808-5813
1996
Escherichia coli
Slominska, M.; Wahl, A.; Wegrzyn, G.; Skarstad, K.
Degradation of mutant initiator protein DnaA204 by proteases ClpP, ClpQ and Lon is prevented when DNA is SeqA-free
Biochem. J.
370
867-871
2003
Escherichia coli
Seong, I.S.; Oh, J.Y.; Yoo, S.J.; Seol, J.H.; Chung, C.H.
ATP-dependent degradation of SulA, a cell division inhibitor, by the HslVU protease in Escherichia coli
FEBS Lett.
456
211-214
1999
Escherichia coli
Song, H.K.; Hartmann, C.; Ramachandran, R.; Bochtler, M.; Behrendt, R.; Moroder, L.; Huber, R.
Mutational studies on HslU and its docking mode with HslV
Proc. Natl. Acad. Sci. USA
97
14103-14108
2000
Escherichia coli, Escherichia coli (Q8FBC0)
Wang, J.
A corrected quaternary arrangement of the peptidase HslV and atpase HslU in a cocrystal structure
J. Struct. Biol.
134
15-24
2001
Escherichia coli
Wang, J.; Song, J.J.; Franklin, M.C.; Kamtekar, S.; Im, Y.J.; Rho, S.H.; Seong, I.S.; Lee, C.S.; Chung, C.H.; Eom, S.H.
Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism
Structure
9
177-184
2001
Escherichia coli
Missiakas, D.; Schwager, F.; Betton, J.M.; Georgopoulos, C.; Raina, S.
Identification and characterization of HsIV HsIU (ClpQ ClpY) proteins involved in overall proteolysis of misfolded proteins in Escherichia coli
EMBO J.
15
6899-6909
1996
Escherichia coli
Rohrwild, M.; Pfeifer, G.; Santarius, U.; Muller, S.A.; Huang, H.C.; Engel, A.; Baumeister, W.; Goldberg, A.L.
The ATP-dependent HslVU protease from Escherichia coli is a four-ring structure resembling the proteasome
Nat. Struct. Biol.
4
133-139
1997
Escherichia coli
Kessel, M.; Wu, W.; Gottesman, S.; Kocsis, E.; Steven, A.C.; Maurizi, M.R.
Six-fold rotational symmetry of ClpQ, the E. coli homolog of the 20S proteasome, and its ATP-dependent activator, ClpY
FEBS Lett.
398
274-278
1996
Escherichia coli
Seol, J.H.; Yoo, S.J.; Shin, D.H.; Shim, Y.K.; Kang, M.S.; Goldberg, A.L.; Chung, C.H.
The heat-shock protein HslVU from Escherichia coli is a protein-activated ATPase as well as an ATP-dependent proteinase
Eur. J. Biochem.
247
1143-1150
1997
Escherichia coli
Ramachandran, R.; Hartmann, C.; Song, H.K.; Huber, R.; Bochtler, M.
Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY)
Proc. Natl. Acad. Sci. USA
99
7396-7401
2002
Haemophilus influenzae
Kwon, A.R.; Kessler, B.M.; Overkleeft, H.S.; McKay, D.B.
Structure and reactivity of an asymmetric complex between HslV and I-domain deleted HslU, a prokaryotic homolog of the eukaryotic proteasome
J. Mol. Biol.
330
185-195
2003
Haemophilus influenzae
Wei, J.; Goldberg, M.B.; Burland, V.; et al.
Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T
Infect. Immun.
71
2775-2786
2003
Shigella flexneri, Shigella flexneri 2457T / ATCC 700930
Wang, J.; Rho, S.H.; Park, H.H.; Eom, S.H.
Correction of X-ray intensities from an HslV-HslU co-crystal containing lattice-translocation defects
Acta Crystallogr. Sect. D
61
932-941
2005
Bacillus subtilis, Escherichia coli
Frees, D.; Thomsen, L.E.; Ingmer, H.
Staphylococcus aureus ClpYQ plays a minor role in stress survival
Arch. Microbiol.
183
286-291
2005
Staphylococcus aureus
Park, E.; Rho, Y.M.; Koh, O.J.; Ahn, S.W.; Seong, I.S.; Song, J.J.; Bang, O.; Seol, J.H.; Wang, J.; Eom, S.H.; Chung, C.H.
Role of the GYVG pore motif of HslU ATPase in protein unfolding and translocation for degradation by HslV peptidase
J. Biol. Chem.
280
22892-22898
2005
Escherichia coli
Kwon, A.R.; Trame, C.B.; McKay, D.B.
Kinetics of protein substrate degradation by HslUV
J. Struct. Biol.
146
141-147
2004
Haemophilus influenzae
Kuo, M.S.; Chen, K.P.; Wu, W.F.
Regulation of RcsA by the ClpYQ (HslUV) protease in Escherichia coli
Microbiology
150
437-446
2004
Escherichia coli
Burton, R.E.; Baker, T.A.; Sauer, R.T.
Nucleotide-dependent substrate recognition by the AAA+ HslUV protease
Nat. Struct. Mol. Biol.
12
245-251
2005
Escherichia coli
Azim, M.K.; Goehring, W.; Song, H.K.; Ramachandran, R.; Bochtler, M.; Goettig, P.
Characterization of the HslU chaperone affinity for HslV protease. [Erratum to document cited in CA143:073777]
Protein Sci.
14
2484
2005
Escherichia coli
-
Lee, J.W.; Park, E.; Bang, O.; Eom, S.H.; Cheong, G.W.; Chung, C.H.; Seol, J.H.
Nucleotide triphosphates inhibit the degradation of unfolded proteins by HslV peptidase
Mol. Cell
23
252-257
2007
Escherichia coli
Lau-Wong, I.C.; Locke, T.; Ellison, M.J.; Raivio, T.L.; Frost, L.S.
HslVU protease
Mol. Microbiol.
67
516-527
2008
Escherichia coli
Azim, M.K.; Noor, S.
Characterization of protomer interfaces in HslV protease, the bacterial homologue of 20S proteasome
Protein J.
26
213-219
2007
Escherichia coli, Haemophilus influenzae, Thermotoga maritima
Rho, S.; Park, H.H.; Kang, G.B.; Im, Y.J.; Kang, M.S.; Lim, B.K.; Seong, I.S.; Seol, J.; Chung, C.H.; Wang, J.; Eom, S.H.
Crystal structure of Bacillus subtilis CodW, a noncanonical HslV-like peptidase with an impaired catalytic apparatus
Proteins Struct. Funct. Bioinform.
71
1020-1026
2008
Bacillus subtilis
Park, E.; Lee, J.W.; Eom, S.H.; Seol, J.H.; Chung, C.H.
Binding of MG132 or deletion of the Thr active sites in HslV subunits increases the affinity of HslV protease for HslU ATPase and makes this interaction nucleotide-independent
J. Biol. Chem.
283
33258-33266
2008
Escherichia coli
Koodathingal, P.; Jaffe, N.E.; Kraut, D.A.; Prakash, S.; Fishbain, S.; Herman, C.; Matouschek, A.
ATP-dependent proteases differ substantially in their ability to unfold globular proteins.
J. Biol. Chem.
284
18674-18684
2009
Escherichia coli, Haemophilus influenzae
Subramaniam, S.; Mohmmed, A.; Gupta, D.
Molecular modeling studies of the interaction between Plasmodium falciparum HslU and HslV subunits.
J. Biomol. Struct. Dyn.
26
473-479
2009
Plasmodium falciparum
Yakamavich, J.A.; Baker, T.A.; Sauer, R.T.
Asymmetric nucleotide transactions of the HslUV protease
J. Mol. Biol.
380
946-957
2008
Escherichia coli
Lee, J.W.; Park, E.; Bang, O.; Eom, S.H.; Cheong, G.W.; Chung, C.H.; Seol, J.H.
Nucleotide triphosphates inhibit the degradation of unfolded proteins by HslV peptidase
Mol. Cells
23
252-257
2007
Escherichia coli
Lien, H.Y.; Shy, R.S.; Peng, S.S.; Wu, Y.L.; Weng, Y.T.; Chen, H.H.; Su, P.C.; Ng, W.F.; Chen, Y.C.; Chang, P.Y.; Wu, W.F.
Characterization of the Escherichia coli ClpY (HslU) substrate recognition site in the ClpYQ (HslUV) protease using the yeast two-hybrid system
J. Bacteriol.
191
4218-4231
2009
Escherichia coli
Lee, J.W.; Park, E.; Jeong, M.S.; Jeon, Y.J.; Eom, S.H.; Seol, J.H.; Chung, C.H.
HslVU ATP-dependent protease utilizes maximally six among twelve threonine active sites during proteolysis
J. Biol. Chem.
284
33475-33484
2009
Escherichia coli
Lien, H.Y.; Yu, C.H.; Liou, C.M.; Wu, W.F.
Regulation of clpQY (hslVU) gene expression in Escherichia coli
Open Microbiol. J.
3
29-39
2009
Escherichia coli
Barboza, N.R.; Cardoso, J.; de Paula Lima, C.V.; Soares, M.J.; Gradia, D.F.; Hangai, N.S.; Bahia, M.T.; Lana, M.; Krieger, M.A.; Sa, R.G.
Expression profile and subcellular localization of HslV, the proteasome related protease from Trypanosoma cruzi
Exp. Parasitol.
130
171-177
2012
Trypanosoma cruzi, Trypanosoma cruzi Y, Trypanosoma cruzi Be-78, Trypanosoma cruzi Dcm28, Trypanosoma cruzi Be-62
Hsieh, F.C.; Chen, C.T.; Weng, Y.T.; Peng, S.S.; Chen, Y.C.; Huang, L.Y.; Hu, H.T.; Wu, Y.L.; Lin, N.C.; Wu, W.F.
Stepwise activity of ClpY (HslU) mutants in the processive degradation of Escherichia coli ClpYQ (HslUV) protease substrates
J. Bacteriol.
193
5465-5476
2011
Escherichia coli
Sundar, S.; McGinness, K.E.; Baker, T.A.; Sauer, R.T.
Multiple sequence signals direct recognition and degradation of protein substrates by the AAA+ protease HslUV
J. Mol. Biol.
403
420-429
2010
Escherichia coli
Sundar, S.; Baker, T.A.; Sauer, R.T.
The I domain of the AAA+ HslUV protease coordinates substrate binding, ATP hydrolysis, and protein degradation
Protein Sci.
21
188-198
2012
Escherichia coli
Mbang-Benet, D.E.; Sterkers, Y.; Morelle, C.; Kebe, N.M.; Crobu, L.; Portales, P.; Coux, O.; Hernandez, J.F.; Meghamla, S.; Pages, M.; Bastien, P.
The bacterial-like HslVU protease complex subunits are involved in the control of different cell cycle events in trypanosomatids
Acta Trop.
131
22-31
2014
Leishmania major (Q4Q116 and Q4QI03), Leishmania major, Leishmania major Friedlin (Q4Q116 and Q4QI03), Trypanosoma brucei (Q383Q5 and Q57VB1 and Q382V8), Trypanosoma brucei, Trypanosoma brucei 427 MiTat1.2 (Q383Q5 and Q57VB1 and Q382V8)
Rashid, Y.; Kamran Azim, M.; Saify, Z.S.; Khan, K.M.; Khan, R.
Small molecule activators of proteasome-related HslV peptidase
Bioorg. Med. Chem. Lett.
22
6089-6094
2012
Escherichia coli, Haemophilus influenzae (P43772)
Chrobak, M.; Foerster, S.; Meisel, S.; Pfefferkorn, R.; Foerster, F.; Clos, J.
Leishmania donovani HslV does not interact stably with HslU proteins
Int. J. Parasitol.
42
329-339
2012
Leishmania donovani, Leishmania donovani 1SR
Park, E.; Lee, J.W.; Yoo, H.M.; Ha, B.H.; An, J.Y.; Jeon, Y.J.; Seol, J.H.; Eom, S.H.; Chung, C.H.
Structural alteration in the pore motif of the bacterial 20S proteasome homolog HslV leads to uncontrolled protein degradation
J. Mol. Biol.
425
2940-2954
2013
Escherichia coli (P0A7B8), Escherichia coli
Ambro, L.; Pevala, V.; Bauer, J.; Kutejova, E.
The influence of ATP-dependent proteases on a variety of nucleoid-associated processes
J. Struct. Biol.
179
181-192
2012
Plasmodium falciparum, Trypanosoma brucei, Escherichia coli (P0A7B8)
Shi, L.; Kay, L.E.
Tracing an allosteric pathway regulating the activity of the HslV protease
Proc. Natl. Acad. Sci. USA
111
2140-2145
2014
Haemophilus influenzae
Dong, S.; Hu, W.; Ge, Y.; Ojcius, D.; Lin, X.; Yan, J.
A leptospiral AAA+ chaperone-Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis
Emerg. Microbes Infect.
6
e105
2017
Leptospira interrogans serovar Canicola (A0A0N7ELI3 and A0A0N9ELN0)
Kebe, N.M.; Samanta, K.; Singh, P.; Lai-Kee-Him, J.; Apicella, V.; Payrot, N.; Lauraire, N.; Legrand, B.; Lisowski, V.; Mbang-Benet, D.E.; Pages, M.; Bastien, P.; Kajava, A.V.; Bron, P.; Hernandez, J.F.; Coux, O.
The HslV protease from Leishmania major and its activation by C-terminal HslU peptides
Int. J. Mol. Sci.
20
1021
2019
Leishmania major (A4HWA6), Leishmania major
Ogden, A.; McAleer, J.; Kahn, M.
Characterization of the Sinorhizobium meliloti HslUV and ClpXP protease systems in free-living and symbiotic states
J. Bacteriol.
201
e00498
2019
Sinorhizobium meliloti (Q92TA7 and Q92TA9), Sinorhizobium meliloti
Baytshtok, V.; Chen, J.; Glynn, S.E.; Nager, A.R.; Grant, R.A.; Baker, T.A.; Sauer, R.T.
Covalently linked HslU hexamers support a probabilistic mechanism that links ATP hydrolysis to protein unfolding and translocation
J. Biol. Chem.
292
5695-5704
2017
Escherichia coli (P0A6H5 and P0A7B8)
Honore, F.A.; Maillot, N.J.; Mejean, V.; Genest, O.
Interplay between the Hsp90 chaperone and the HslVU protease to regulate the level of an essential protein in Shewanella oneidensis
mBio
10
e00269
2019
Shewanella oneidensis
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