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Information on EC 3.4.24.B5 - matrix metalloproteinase-15 and Organism(s) Mus musculus and UniProt Accession O54732

for references in articles please use BRENDA:EC3.4.24.B5
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B5 matrix metalloproteinase-15
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This record set is specific for:
Mus musculus
UNIPROT: O54732
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
proteolytic degradation of proteins
Synonyms
mt2-mmp, mmp15, mmp-15, membrane-type matrix metalloproteinase, membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 15, mt1 mmp, matrix metalloproteinase-15, membrane-type-2 matrix metalloproteinase, mt2-mmp/mmp15, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
M10.015
Merops-ID
membrane-type matrix metalloproteinase 2
-
membrane-type-2 matrix metalloproteinase
-
MMP-15
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
CAS REGISTRY NUMBER
COMMENTARY hide
172308-17-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
protein + H2O
peptides
show the reaction diagram
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
protein + H2O
peptides
show the reaction diagram
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
trends in expression of MMP-15 is similar between brain and spinal cord samples
Manually annotated by BRENDA team
-
small expression
Manually annotated by BRENDA team
-
MMP-15 is expressed at a significantly higher level by myeloid cells than by T cells
Manually annotated by BRENDA team
-
MMP-15 is mainly expressed by resting microglia, and this is reduced 15fold in experimental autoimmune encephalomyelitis
Manually annotated by BRENDA team
-
MMP-15 message is down-regulated 5.5fold in experimental autoimmune encephalomyelitis
Manually annotated by BRENDA team
additional information
-
T-cell
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
membrane-anchored
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
branching morphogenesis is thought to depend on the mobilization of the membrane-anchored matrix metalloproteinases MMP14 (MT1-MMP) and MMP15 (MT2-MMP), which drive epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. Different roles played by MMP14 or MMP15 in the mammary gland epithelial compartment and in development of mammary gland, overview. Whereas MMP14 promotes white fat-associated adipogenesis in the developing mammary gland, MMP15 serves as an endogenous suppressor of beige/brown fat production
physiological function
metalloproteinase MMP15 (MT2-MMP) drives epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. It plays a role in mammary gland development. Transcriptome profiling reveals a key role for MMP14 and MMP15 in regulating mammary gland adipocyte differentiation. MMP15 differentially controls the formation of thermogenic brown fat. Neonatal mammary gland branching proceeds in the absence of MMP15, early mammary epithelial branching is Mmp15 independent
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MMP15_MOUSE
657
0
74666
Swiss-Prot
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
MMP15 enzyme knockout in mammary gland epithelial cells
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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MMP-15 is downregulated in experimental autoimmune encephalomyelitis, expression of MMP-15 correlates with disease course
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (P51511), Mus musculus (O54732)
Manually annotated by BRENDA team
Toft-Hansen, H.; Nuttall, R.K.; Edwards, D.R.; Owens, T.
Key metalloproteinases are expressed by specific cell types in experimental autoimmune encephalomyelitis
J. Immunol.
173
5209-5218
2004
Mus musculus
Manually annotated by BRENDA team
Feinberg, T.Y.; Rowe, R.G.; Saunders, T.L.; Weiss, S.J.
Functional roles of MMP14 and MMP15 in early postnatal mammary gland development
Development
143
3956-3968
2016
Mus musculus (O54732)
Manually annotated by BRENDA team