Information on EC 3.4.24.B37 - mutalysin II

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The expected taxonomic range for this enzyme is: Lachesis muta muta

EC NUMBER
COMMENTARY hide
3.4.24.B37
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
mutalysin II
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
The enzyme cleaves the Ala14-/-Leu15 bond of insulin B-chain very rapidly and the Phe24-/-Phe25, His10-/-Leu11 and His5-/-Leu6 bonds more slowly
show the reaction diagram
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-
-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-aminobenzoyl-Pro-Leu-Gly-Leu-Leu-Gly-Arg-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Pro-Leu-Gly-Leu + Leu-Gly-Arg-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
-
-
-
?
Bovine insulin B-chain + H2O
?
show the reaction diagram
-
the enzyme cleaves the Ala14-/-Leu15 bond of insulin B-chain very rapidly and the Phe24-/-Phe25, His10-/-Leu11 and His5-/-Leu6 bonds more slowly
-
-
?
casein + H2O
?
show the reaction diagram
-
-
-
-
?
Dimethylcasein + H2O
?
show the reaction diagram
-
-
-
-
?
dimethylcaseion + H2O
?
show the reaction diagram
-
-
-
-
?
Fibrin + H2O
?
show the reaction diagram
-
-
-
-
?
fibrinogen alpha-chain + H2O
?
show the reaction diagram
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the enzyme hydrolyzes selectively the alpha-chain of fibrinogen, leaving the beta- and gamma-chains unaffected
-
-
?
human fibrin + H2O
?
show the reaction diagram
-
-
-
-
?
human fibrinogen alpha-chain + H2O
?
show the reaction diagram
-
-
-
-
?
murine fibrin + H2O
?
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
human fibrin + H2O
?
show the reaction diagram
-
-
-
-
?
human fibrinogen alpha-chain + H2O
?
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
contains one gatom zinc and two gatom calcium per mol protein. The enzyme is activated by Ca2+
Cu2+
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Zn2+ and Cu2+-containing metalloproteinase
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
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hemorrhagic as well as the proteinase activity is inhibited
EGTA
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hemorrhagic as well as the proteinase activity is inhibited
human alpha-2-macroglobulin
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activity with dimethylcasein as substrate is completely inhibited, inhibition of of fibrin(ogen) digestion
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rabbit antibody to mutalysin II
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activity with dimethylcasein as substrate is completely inhibited, inhibition of of fibrin(ogen) digestion
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22596
-
x * 22596, calculated from sequence
23000
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x * 23000, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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mutalysin II has the potential to be an effective thrombolytic agent