Information on EC 3.4.24.B27 - ADAM19

Word Map on EC 3.4.24.B27
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Homo sapiens

EC NUMBER
COMMENTARY hide
3.4.24.B27
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
ADAM19
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
proteolysis of proteins
show the reaction diagram
-
-
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
ADAM19 autolysis promotes non-classical secretion of cysteine-rich protein 2 (CRIP2). CRIP2 secretion is increased by overexpression of ADAM19 and decreased by suppression of ADAM19 expression
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
pro-renin receptor + H2O
fragments of pro-renin receptor
show the reaction diagram
-
the pro-renin receptor is cleaved by ADAM19 in the Golgi leading to the secretion of its N-terminal fragment into extracellular space
-
-
?
additional information
?
-
-
ADAM19 autolysis is activated by lipopolysaccharide
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
pro-renin receptor + H2O
fragments of pro-renin receptor
show the reaction diagram
-
the pro-renin receptor is cleaved by ADAM19 in the Golgi leading to the secretion of its N-terminal fragment into extracellular space
-
-
?
additional information
?
-
-
ADAM19 autolysis is activated by lipopolysaccharide
-
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
in choriocarcinoma cell line JEG-3, the overexpression of ADAM19 leads to diminished cell invasion, as well as increases in cell adhesiveness and the expression of E-cadherin, with no changes in beta-catenin expression
Manually annotated by BRENDA team
-
ADAM19 is widely distributed in villous cytotrophoblast cells, syncytiotrophoblast cells, column trophoblasts, and villous capillary endothelial cells during early pregnancy. The mRNA and protein level of ADAM19 in placentas is high at gestational weeks 8-9, but diminishes significantly at mid- and term pregnancy
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in H-4 cells and COS-7 cells
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
mRNA and protein level of ADAM19 in placentas diminishe significantly at mid- and term pregnancy
-
mRNA and protein level of ADAM19 in placentas is high at gestational weeks 8-9
-
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E346A
-
catalytically inactive