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Information on EC 3.4.24.86 - ADAM 17 endopeptidase and Organism(s) Sus scrofa and UniProt Accession O77636

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.86 ADAM 17 endopeptidase
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Sus scrofa
UNIPROT: O77636 not found.
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Word Map
The taxonomic range for the selected organisms is: Sus scrofa
The enzyme appears in selected viruses and cellular organisms
Synonyms
adam17, adam-17, tnf-alpha converting enzyme, tace/adam17, a disintegrin and metalloproteinase 17, tumor necrosis factor-alpha converting enzyme, a disintegrin and metalloprotease 17, tumor necrosis factor-alpha-converting enzyme, metalloproteinase adam17, tumor necrosis factor alpha-converting enzyme, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ADAM-17
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ADAM17 proteinase
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metalloprotease TACE
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metalloproteinase ADAM17
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pro tumor necrosis factor cleavage enzyme
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pro-tumor necrosis factor-alpha-processing enzyme
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proteinase, pro-tumor necrosis factor (9CI)
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TACE proteinase
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TNF-alpha convertase
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TNF-alpha converting enzyme
TNF-alpha processing protease
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tumor necrosis factor alpha convertase
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tumor necrosis factor alpha-converting enzyme
tumor necrosis factor-alpha converting enzyme
CAS REGISTRY NUMBER
COMMENTARY hide
151769-16-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
75kDaTNFR2 + H2O
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show the reaction diagram
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?
p55 TNFR1 + H2O
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show the reaction diagram
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p75 tumour necrosis factor receptor + H2O
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show the reaction diagram
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TNF-alpha + H2O
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show the reaction diagram
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transforming growth factor alpha + H2O
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show the reaction diagram
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additional information
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compounds are assessed in two cellular assays, the human peripheral blood mononuclear cell assay (PBMC) and the human whole blood assay (WBA), for their ability to suppress the formation of TNF-alpha brought about by lipopolysaccharide (LPS) stimulation. Success in the PBMC assay relies on the ability of the inhibitor to penetrate into the cells, thus enabling it to inhibit TACE and thereby to suppress the release of intracellular, soluble TNF-alpha. In the WBA, compounds must also have the ability to penetrate cells
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R)-N-hydroxy-2-(7-methoxy-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl)-3-methylbutanamide
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(3R,4R)-4-([[4-(1,3-dihydrofuro[3,4-b]quinolin-9-ylmethyl)phenyl]carbonyl]amino)-N-hydroxytetrahydro-2H-pyran-3-carboxamide
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(3R,4R)-4-([[4-(2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylmethyl)phenyl]carbonyl]amino)-N-hydroxytetrahydro-2H-pyran-3-carboxamide
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(3R,4R)-4-([[4-(2,3-dihydrofuro[2,3-b]quinolin-4-ylmethyl)phenyl]carbonyl]amino)-N-hydroxytetrahydro-2H-pyran-3-carboxamide
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(3R,4R)-4-[([4-[(2,3-dimethylquinolin-4-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-3-carboxamide
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(3R,4R)-4-[([4-[(2-cyclopropylquinolin-4-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-3-carboxamide
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(3R,4R)-4-[([4-[(2-ethylquinolin-4-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-3-carboxamide
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(3R,4R)-4-[([4-[(3-ethyl-2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-3-carboxamide
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(3R,4R)-4-[[(4-[[2-(dimethylamino)quinolin-4-yl]methyl]phenyl)carbonyl]amino]-N-hydroxytetrahydro-2H-pyran-3-carboxamide
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-
(3R,4R)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]tetrahydro-2H-pyran-3-carboxamide
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-
(3R,4R)-N-hydroxy-4-[([4-[(2-morpholin-4-ylquinolin-4-yl)methyl]phenyl]carbonyl)amino]tetrahydro-2H-pyran-3-carboxamide
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-
(3R,4R)-N-hydroxy-4-[([4-[(3-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]tetrahydro-2H-pyran-3-carboxamide
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(3R,4R)-N-hydroxy-4-[[(4-[[2-(1-methylethyl)quinolin-4-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-3-carboxamide
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-
(3R,4R)-N-hydroxy-4-[[(4-[[2-(trifluoromethyl)quinolin-4-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-3-carboxamide
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(3R,4S)-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
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(3R,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]tetrahydrofuran-3-carboxamide
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(3S)-1-[[4-(but-2-yn-1-yloxy)phenyl]sulfonyl]pyrrolidine-3-thiol
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(3S,4R)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-3-carboxamide
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(3S,4S)-1-(2,2-dimethylpropanoyl)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-1-(2,2-dimethylpropyl)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-1-(butylsulfonyl)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-1-(furan-2-ylmethyl)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-1-acetyl-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-1-but-2-yn-1-yl-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-1-cyclobutyl-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-1-tert-butyl-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
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(3S,4S)-1-[2-(dimethylamino)ethyl]-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
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(3S,4S)-3-[([4-[(2-cyclopropylimidazo[1,2-a]pyridin-3-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-4-carboxamide
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(3S,4S)-3-[([4-[(2-ethyl-1H-indol-3-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-4-carboxamide
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(3S,4S)-3-[([4-[(2-ethylpyrazolo[1,5-a]pyridin-3-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-4-carboxamide
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(3S,4S)-3-[([4-[(2-tert-butylpyrazolo[1,5-a]pyridin-3-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-4-carboxamide
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(3S,4S)-N-hydroxy-1-(1-methylethyl)-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-1-(2-methylprop-2-en-1-yl)-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-1-(2-methylpropanoyl)-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-1-(2-methylpropyl)-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-1-(2-methylpropyl)-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-1-methyl-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-1-methyl-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-3-[([4-[(2-methyl-1-benzofuran-3-yl)methyl]phenyl]carbonyl)amino]tetrahydro-2H-pyran-4-carboxamide
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(3S,4S)-N-hydroxy-3-[([4-[(2-methyl-1H-indol-3-yl)methyl]phenyl]carbonyl)amino]tetrahydro-2H-pyran-4-carboxamide
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(3S,4S)-N-hydroxy-3-[([4-[(2-methylimidazo[1,2-a]pyridin-3-yl)methyl]phenyl]carbonyl)amino]tetrahydro-2H-pyran-4-carboxamide
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(3S,4S)-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
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(3S,4S)-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]tetrahydro-2H-pyran-4-carboxamide
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(3S,4S)-N-hydroxy-3-[[(4-[[2-(1-methylethyl)-1-benzofuran-3-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-4-carboxamide
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(3S,4S)-N-hydroxy-3-[[(4-[[2-(1-methylethyl)imidazo[1,2-a]pyridin-3-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-4-carboxamide
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(3S,4S)-N-hydroxy-3-[[(4-[[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-4-carboxamide
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(3S,4S)-N-hydroxy-3-[[(4-[[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-4-carboxamide
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(3S,4S)-N-hydroxy-3-[[(4-[[2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-4-carboxamide
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substance exhibits excellent oral bioavailability in pharmacokinetic studies
(3S,4S)-N-hydroxy-4-[([4-[(2-methyl-1-benzofuran-3-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-4-[([4-[(2-methyl-1H-indol-3-yl)methyl]phenyl]carbonyl)amino]-1-prop-2-yn-1-ylpyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-4-[([4-[(2-methyl-1H-indol-3-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1-phenylpyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1-prop-2-en-1-ylpyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]-1-prop-2-yn-1-ylpyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)oxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
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(3S,4S)-N-hydroxy-4-[[(4-[[2-(1-methylethyl)-1-benzofuran-3-yl]methyl]phenyl)carbonyl]amino]pyrrolidine-3-carboxamide
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(5R,6R)-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,4-dioxo-1,3-diazaspiro[4.4]nonane-6-carboxamide
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(5R,6S)-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,4-dioxo-1,3-diazaspiro[4.4]nonane-6-carboxamide
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(5R,7S,8R)-N-hydroxy-8-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1-oxaspiro[4.4]nonane-7-carboxamide
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(5S,6R)-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,4-dioxo-1,3-diazaspiro[4.5]decane-6-carboxamide
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(5S,6S)-N-hydroxy-5-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-2,3,5,6-tetrahydro-4aH-cyclopenta[b][1,4]dioxine-6-carboxamide
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(5S,7S,8R)-N-hydroxy-8-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1-oxaspiro[4.4]nonane-7-carboxamide
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(7S,8R)-N-hydroxy-8-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1,4-dioxaspiro[4.4]nonane-7-carboxamide
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1-methylethyl (3S,4S)-3-(hydroxycarbamoyl)-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-1-carboxylate
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1-[4-[(2-methylquinolin-4-yl)methoxy]benzyl]-1,3,5-triazinane-2,4,6-trione
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IC50: 0.0073 mM
13-[(4R)-2,5-dioxoimidazolidin-4-yl]-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]tridecanamide
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2,6-anhydro-3,4,5-trideoxy-1-(hydroxyamino)-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-D-threo-hexose
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2-[(5R,6R)-2,4-dioxo-1,3-diazaspiro[4.4]non-6-yl]-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]acetamide
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2-[(5R,6S)-2,4-dioxo-1,3-diazaspiro[4.4]non-6-yl]-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]acetamide
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2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]acetamide
2-[[4-(but-2-yn-1-ylamino)phenyl]sulfonyl]ethanethiol
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2-[[4-(but-2-yn-1-yloxy)phenyl]sulfonyl]ethanethiol
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2-[[[4-(but-2-yn-1-yloxy)phenyl]sulfonyl](methyl)amino]-N-hydroxyacetamide
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3-[[4-(but-2-yn-1-ylamino)phenyl]sulfonyl]cyclohexanethiol
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3-[[4-(but-2-yn-1-ylamino)phenyl]sulfonyl]propane-1-thiol
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3-[[4-(but-2-yn-1-yloxy)phenyl]sulfonyl]cyclohexanethiol
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3-[[4-(but-2-yn-1-yloxy)phenyl]sulfonyl]cyclopentanethiol
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3-[[4-(but-2-yn-1-yloxy)phenyl]sulfonyl]propane-1-thiol
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4-[(2-methylquinolin-4-yl)methoxy]-N-(1,3,5-trioxo-2,4-diazaspiro[5.5]undec-7-yl)benzamide
4-[(2-methylquinolin-4-yl)methoxy]-N-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)benzamide
4-[(2-methylquinolin-4-yl)methoxy]-N-(6,8,10-trioxo-2-oxa-7,9-diazaspiro[4.5]dec-4-yl)benzamide
4-[(2-methylquinolin-4-yl)methoxy]-N-(6,8,10-trioxo-7,9-diazaspiro[4.5]dec-1-yl)benzamide
4-[(2-methylquinolin-4-yl)methoxy]-N-([2,4,6-trioxo-5-[1-(tetrahydro-2H-pyran-2-yl)piperidin-4-yl]hexahydropyrimidin-5-yl]methyl)benzamide
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4-[(2-methylquinolin-4-yl)methoxy]-N-([2,4,6-trioxo-5-[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]hexahydropyrimidin-5-yl]methyl)benzamide
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IC50: 0.000031 mM
4-[(2-methylquinolin-4-yl)methoxy]-N-([2,4,6-trioxo-5-[4-(pyridin-3-ylcarbonyl)piperazin-1-yl]hexahydropyrimidin-5-yl]methyl)benzamide
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IC50: 0.00001 mM
4-[(2-methylquinolin-4-yl)methoxy]-N-([5-[1-(methylsulfonyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)benzamide
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IC50: 0.000029 mM
4-[(2-methylquinolin-4-yl)methoxy]-N-([5-[4-(methylsulfonyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)benzamide
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IC50: 0.000002 mM
4-[(2-methylquinolin-4-yl)methoxy]-N-[(2,4,6-trioxo-5-phenylhexahydropyrimidin-5-yl)methyl]benzamide
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4-[(2-methylquinolin-4-yl)methoxy]-N-[(2,4,6-trioxo-5-piperidin-4-ylhexahydropyrimidin-5-yl)methyl]benzamide
4-[(2-methylquinolin-4-yl)methoxy]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)(pyridin-4-yl)methyl]benzamide
4-[(2-methylquinolin-4-yl)methoxy]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]benzamide
4-[(2-methylquinolin-4-yl)methoxy]-N-[2-(methylsulfonyl)-6,8,10-trioxo-2,7,9-triazaspiro[4.5]dec-4-yl]benzamide
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IC50: 0.000036 mM
4-[(2-methylquinolin-4-yl)methoxy]-N-[6,8,10-trioxo-2-(pyridin-3-ylcarbonyl)-2,7,9-triazaspiro[4.5]dec-4-yl]benzamide
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IC50: 0.000029 mM
4-[(2-methylquinolin-4-yl)methoxy]-N-[[2,4,6-trioxo-5-(4-phenylpiperazin-1-yl)hexahydropyrimidin-5-yl]methyl]benzamide
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5-(4-acetylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
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IC50: 0.00062 mM
5-(4-benzylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
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IC50: 0.000195 mM
5-(4-hexylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
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IC50: 0.000081 mM
5-(4-methylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
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IC50: 0.000091 mM
5-methyl-5-(2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]ethyl)pyrimidine-2,4,6(1H,3H,5H)-trione
5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-3-oxopropyl)pyrimidine-2,4,6(1H,3H,5H)-trione
5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
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IC50: 0.011 mM
5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]propyl)pyrimidine-2,4,6(1H,3H,5H)-trione
5-methyl-5-[(2E)-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]prop-2-en-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione
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-
5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]benzyl]pyrimidine-2,4,6(1H,3H,5H)-trione
5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenoxy]pyrimidine-2,4,6(1H,3H,5H)-trione
5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]dihydropyrimidine-2,4(1H,3H)-dione
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IC50: 0.0037 mM
5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
5-[4-(1-methylethyl)piperazin-1-yl]-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
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IC50: 0.000096 mM
5-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
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IC50: 0.00054 mM
5-[4-(2,2-dimethylpropyl)piperazin-1-yl]-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
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IC50: 0.00016 mM
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-(pyridin-3-ylcarbonyl)pyrimidine-2,4,6(1H,3H,5H)-trione
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IC50: 0.000535 mM
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-piperazin-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione
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IC50: 0.0011 mM
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-piperidin-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione
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IC50: 0.000855 mM
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(2-phenylethyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione
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IC50: 0.000084 mM
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(3-phenylpropyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione
-
IC50: 0.00011 mM
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(4-nitrophenyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione
-
IC50: 0.0028 mM
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(methylsulfonyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione
-
IC50: 0.000275 mM
7-(1-methyl-2,5-dioxoimidazolidin-4-yl)-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]heptanamide
-
-
7-(2,5-dioxoimidazolidin-4-yl)-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]heptanamide
-
-
7-(3-methyl-2,5-dioxoimidazolidin-4-yl)-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]heptanamide
-
-
7-[(4R)-2,5-dioxoimidazolidin-4-yl]-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]heptanamide
-
-
7-[(4S)-2,5-dioxoimidazolidin-4-yl]-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]heptanamide
-
-
macrocyclic hydroxamic acid
-
-
methyl (3S,4S)-3-(hydroxycarbamoyl)-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-1-carboxylate
-
-
methyl (3S,4S)-3-(hydroxycarbamoyl)-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-1-carboxylate
-
-
methyl (5R)-5-{7-[(3,5-diethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl}-6-(hydroxyamino)-6-oxohexanoate
-
-
methyl (5R)-5-{7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl}-6-(hydroxyamino)-6-oxohexanoate
-
human whole blood assay: 31% inhibition
methyl 4-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,5-dioxoimidazolidine-4-carboxylate
-
IC50: 0.0047 mM
N-(2-acetyl-6,8,10-trioxo-2,7,9-triazaspiro[4.5]dec-4-yl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
IC50: 0.000055 mM
N-(8-acetyl-1,3,5-trioxo-2,4,8-triazaspiro[5.5]undec-11-yl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-([5-[1-(1-methylethyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
N-([5-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
IC50: 0.000013 mM
N-([5-[4-(1-methylethyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
N-([5-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
IC50: 0.000029 mM
N-([5-[4-(5-amino-8-carbamimidamido-4-oxooctyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-hydroxy-2(R)-(6-methoxy-1,1-dioxo-3,4-dihydro-1H-1-benzo[1,2,4]thiadiazin-2-yl)propionamide
-
-
N-hydroxy-2(R)-[2,3,4,5-tetrahydrobenzo[1,2,5-f]-thiadiazepine-1,1-dioxide]propanamide
-
-
N-hydroxy-2(R)-[7-(2,6-methylpyridyl-4-methyleneoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-propanamide
-
human whole blood assay: 37% inhibition
N-hydroxy-2(R)-[7-(2-trifluromethylphenyl)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propylamide
-
-
N-hydroxy-2(R)-[7-(3,5-dichlorobenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
human whole blood assay: 12% inhibition
N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
-
human whole blood assay: 17% inhibition
N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methoxycarbonylbutanamide
-
human whole blood assay: 0% inhibition
N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
human whole blood assay: 26% inhibition
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine 1,1-dioxide]-6-N-(methanesulfonyl)hexylamide
-
-
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
-
human whole blood assay: 11% inhibition
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methoxycarbonylbutanamide
-
human whole blood assay: 0% inhibition
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentanamide
-
human whole blood assay: 16% inhibition
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-6-aminohexylamidetrifluoroacetic acid salt
-
human whole blood assay: 3% inhibition
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-6-N-[(1,1-dimethylethoxy)carbonyl]hexylamide
-
human whole blood assay: 3% inhibition
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
N-hydroxy-2(R)-[7-(3,5-dimethylbenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
human whole blood assay: 2% inhibition
N-hydroxy-2(R)-[7-(3-nitrophenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
N-hydroxy-2(R)-[7-(4,5-dimethylthiazolyl-2-methyleneoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
-
human whole blood assay: 0% inhibition
N-hydroxy-2(R)-[7-(4-methoxyphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
N-hydroxy-2(R)-[7-(4-nitrophenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
N-hydroxy-2(R)-[7-(4-phenylphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
N-hydroxy-2(R)-[7-(4-trifluoromethylphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
human whole blood assay: 58% inhibition
N-hydroxy-2(R)-[7-(N-3,5-dimethylbenzoylamino)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-propylamide
-
-
N-hydroxy-2(R)-[7-benzyloxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentanamide
-
human whole blood assay: 39% inhibition
N-hydroxy-2(R)-[7-benzyloxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
human whole blood assay: 30% inhibition
N-hydroxy-2(R)-[7-hydroxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentamide
-
human whole blood assay: 20% inhibition
N-hydroxy-2(R)-[7-hydroxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
human whole blood assay: 21% inhibition
N-hydroxy-2(R)-[7-methoxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
N-hydroxy-2(R)-[7-N-(3,5-dimethoxymethyleneamino)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentamide
-
human whole blood assay: 3% inhibition
N-hydroxy-2(R)-[7-phenoxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
N-hydroxy-2(R)-[7-phenyl-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propylamide
-
-
N-hydroxy-2-[2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]ethanamide
-
-
N-hydroxy-2-[7-methoxy-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]ethanamide
-
-
N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]tetrahydro-2H-pyran-3-carboxamide
-
-
N-[(1R,2S)-2-(hydroxycarbamoyl)-4-oxocyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[(1R,2S)-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[(1R,2S)-4,4-difluoro-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[(1R,2S)-4-aziridin-1-yl-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[(1R,2S)-4-hydroxy-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[(1S,2R)-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[(4-methyl-2,5-dioxoimidazolidin-4-yl)methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[(5-benzyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
IC50: 0.000018 mM
N-[(5-ethyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
N-[(5R,6R)-2,4-dioxo-1,3-diazaspiro[4.4]non-6-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[(5R,6R)-2,4-dioxo-1,3-diazaspiro[4.5]dec-6-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[(5R,6S)-2,4-dioxo-1,3-diazaspiro[4.4]non-6-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[(5R,9R)-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[(5R,9R)-7-(2-methylpropanoyl)-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[1-(2,5-dioxoimidazolidin-4-yl)ethyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[1-[2-(hydroxyamino)-2-oxoethyl]cyclohexyl]-4-[(2-methylquinolin-4-yl)methyl]benzamide
-
-
N-[2-(2,2-dimethylpropanoyl)-6,8,10-trioxo-2,7,9-triazaspiro[4.5]dec-4-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
IC50: 0.000111 mM
N-[2-(hydroxycarbamoyl)cyclobutyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methyl]benzamide
-
-
N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)acetamide
-
IC50: 0.012 mM
N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-3-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)propanamide
-
-
N-[4-[2-(hydroxyamino)-2-oxoethyl]tetrahydrofuran-3-yl]-4-[(2-methylquinolin-4-yl)methyl]benzamide
-
-
N-[[(4R)-2,5-dioxoimidazolidin-4-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
-
N-[[5-(1-methylethyl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
N-[[5-(1-methylpiperidin-4-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
N-[[5-(4-acetylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
N-[[5-(4-benzylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
IC50: 0.000014 mM
N-[[5-(4-ethynylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
IC50: 0.000062 mM
N-[[5-(4-methylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-1-carboxylate
-
-
tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[([4-[(2-methylquinolin-4-yl)oxy]phenyl]carbonyl)amino]pyrrolidine-1-carboxylate
-
-
tert-butyl (5-[[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]methyl]-2,4,6-trioxohexahydropyrimidin-5-yl)carbamate
tert-butyl (5R,9R)-9-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7-carboxylate
-
-
tert-butyl 11-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1,3,5-trioxo-2,4,8-triazaspiro[5.5]undecane-8-carboxylate
-
-
tert-butyl 4-(5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,4,6-trioxohexahydropyrimidin-5-yl)piperazine-1-carboxylate
-
IC50: 0.00016 mM
tert-butyl 4-(5-[[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]methyl]-2,4,6-trioxohexahydropyrimidin-5-yl)piperidine-1-carboxylate
tert-butyl 4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-6,8,10-trioxo-2,7,9-triazaspiro[4.5]decane-2-carboxylate
-
IC50: 0.000128 mM
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000071
(2R)-N-hydroxy-2-(7-methoxy-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl)-3-methylbutanamide
-
-
0.000028
(3S)-1-[[4-(but-2-yn-1-yloxy)phenyl]sulfonyl]pyrrolidine-3-thiol
-
-
0.000001
(3S,4S)-N-hydroxy-3-[[(4-[[2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-4-carboxamide
-
-
0.000002
2-[[4-(but-2-yn-1-ylamino)phenyl]sulfonyl]ethanethiol
-
-
0.000008
2-[[4-(but-2-yn-1-yloxy)phenyl]sulfonyl]ethanethiol
-
-
0.00001
2-[[[4-(but-2-yn-1-yloxy)phenyl]sulfonyl](methyl)amino]-N-hydroxyacetamide
-
-
0.000017
3-[[4-(but-2-yn-1-ylamino)phenyl]sulfonyl]cyclohexanethiol
-
-
0.0000045
3-[[4-(but-2-yn-1-ylamino)phenyl]sulfonyl]propane-1-thiol
-
-
0.00003
3-[[4-(but-2-yn-1-yloxy)phenyl]sulfonyl]cyclohexanethiol
-
-
0.00005
3-[[4-(but-2-yn-1-yloxy)phenyl]sulfonyl]cyclopentanethiol
-
-
0.00001
3-[[4-(but-2-yn-1-yloxy)phenyl]sulfonyl]propane-1-thiol
-
-
0.000013
methyl (5R)-5-{7-[(3,5-diethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl}-6-(hydroxyamino)-6-oxohexanoate
-
-
0.00001
methyl (5R)-5-{7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl}-6-(hydroxyamino)-6-oxohexanoate
-
-
0.0031
N-hydroxy-2(R)-(6-methoxy-1,1-dioxo-3,4-dihydro-1H-1-benzo[1,2,4]thiadiazin-2-yl)propionamide
-
-
0.000484
N-hydroxy-2(R)-[2,3,4,5-tetrahydrobenzo[1,2,5-f]-thiadiazepine-1,1-dioxide]propanamide
-
-
0.000544
N-hydroxy-2(R)-[7-(2,6-methylpyridyl-4-methyleneoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-propanamide
-
-
0.001
N-hydroxy-2(R)-[7-(2-trifluromethylphenyl)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propylamide
-
value above
0.000153
N-hydroxy-2(R)-[7-(3,5-dichlorobenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
0.000051
N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
-
-
0.000242
N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methoxycarbonylbutanamide
-
-
0.000081
N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
0.000005
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine 1,1-dioxide]-6-N-(methanesulfonyl)hexylamide
-
-
0.00001
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
-
-
0.000177
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methoxycarbonylbutanamide
-
-
0.000017
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentanamide
-
-
0.000031
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-6-aminohexylamidetrifluoroacetic acid salt
-
-
0.000077
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-6-N-[(1,1-dimethylethoxy)carbonyl]hexylamide
-
-
0.000027
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
0.000229
N-hydroxy-2(R)-[7-(3,5-dimethylbenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
0.000129
N-hydroxy-2(R)-[7-(3-nitrophenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
0.00029
N-hydroxy-2(R)-[7-(4,5-dimethylthiazolyl-2-methyleneoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
-
-
0.000621
N-hydroxy-2(R)-[7-(4-methoxyphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
0.000011
N-hydroxy-2(R)-[7-(4-nitrophenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
0.001
N-hydroxy-2(R)-[7-(4-phenylphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
value above
0.000758
N-hydroxy-2(R)-[7-(4-trifluoromethylphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
0.001
N-hydroxy-2(R)-[7-(N-3,5-dimethylbenzoylamino)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-propylamide
-
value above
0.000177
N-hydroxy-2(R)-[7-benzyloxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentanamide
-
-
0.000705
N-hydroxy-2(R)-[7-benzyloxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
0.000089
N-hydroxy-2(R)-[7-hydroxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentamide
-
-
0.000391
N-hydroxy-2(R)-[7-hydroxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
0.000274
N-hydroxy-2(R)-[7-methoxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
0.000056
N-hydroxy-2(R)-[7-N-(3,5-dimethoxymethyleneamino)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentamide
-
-
0.000734
N-hydroxy-2(R)-[7-phenoxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
-
0.001
N-hydroxy-2(R)-[7-phenyl-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propylamide
-
value above
0.001
N-hydroxy-2-[2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]ethanamide
-
-
0.001
N-hydroxy-2-[7-methoxy-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]ethanamide
-
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000026
(3R,4R)-4-([[4-(1,3-dihydrofuro[3,4-b]quinolin-9-ylmethyl)phenyl]carbonyl]amino)-N-hydroxytetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.000001
(3R,4R)-4-([[4-(2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylmethyl)phenyl]carbonyl]amino)-N-hydroxytetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.0000013
(3R,4R)-4-([[4-(2,3-dihydrofuro[2,3-b]quinolin-4-ylmethyl)phenyl]carbonyl]amino)-N-hydroxytetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.0000012
(3R,4R)-4-[([4-[(2,3-dimethylquinolin-4-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.0000013
(3R,4R)-4-[([4-[(2-cyclopropylquinolin-4-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.0000017
(3R,4R)-4-[([4-[(2-ethylquinolin-4-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.0000078
(3R,4R)-4-[([4-[(3-ethyl-2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.0000012
(3R,4R)-4-[[(4-[[2-(dimethylamino)quinolin-4-yl]methyl]phenyl)carbonyl]amino]-N-hydroxytetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.000001
(3R,4R)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]tetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.0000016
(3R,4R)-N-hydroxy-4-[([4-[(2-morpholin-4-ylquinolin-4-yl)methyl]phenyl]carbonyl)amino]tetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.0000015
(3R,4R)-N-hydroxy-4-[([4-[(3-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]tetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.000001
(3R,4R)-N-hydroxy-4-[[(4-[[2-(1-methylethyl)quinolin-4-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
IC50 below 0.000001 mM
0.0000022
(3R,4R)-N-hydroxy-4-[[(4-[[2-(trifluoromethyl)quinolin-4-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.000001
(3R,4S)-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
Sus scrofa
-
IC50 below 0.000001 mM
0.000001 - 0.0000023
(3R,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]tetrahydrofuran-3-carboxamide
0.000024
(3S,4R)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-3-carboxamide
Sus scrofa
-
-
0.0000015
(3S,4S)-1-(2,2-dimethylpropanoyl)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000016
(3S,4S)-1-(2,2-dimethylpropyl)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000011
(3S,4S)-1-(butylsulfonyl)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.000002
(3S,4S)-1-(furan-2-ylmethyl)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000013
(3S,4S)-1-acetyl-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.000001
(3S,4S)-1-but-2-yn-1-yl-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.000001
(3S,4S)-1-cyclobutyl-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.000002
(3S,4S)-1-tert-butyl-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
Sus scrofa
-
-
0.000002
(3S,4S)-1-[2-(dimethylamino)ethyl]-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
Sus scrofa
-
-
0.000001
(3S,4S)-3-[([4-[(2-cyclopropylimidazo[1,2-a]pyridin-3-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
-
0.000001
(3S,4S)-3-[([4-[(2-ethyl-1H-indol-3-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
-
0.000002
(3S,4S)-3-[([4-[(2-ethylpyrazolo[1,5-a]pyridin-3-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
-
0.0000028
(3S,4S)-3-[([4-[(2-tert-butylpyrazolo[1,5-a]pyridin-3-yl)methyl]phenyl]carbonyl)amino]-N-hydroxytetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
-
0.0000004
(3S,4S)-N-hydroxy-1-(1-methylethyl)-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000015
(3S,4S)-N-hydroxy-1-(2-methylprop-2-en-1-yl)-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000021
(3S,4S)-N-hydroxy-1-(2-methylpropanoyl)-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000011
(3S,4S)-N-hydroxy-1-(2-methylpropyl)-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000016
(3S,4S)-N-hydroxy-1-(2-methylpropyl)-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000016
(3S,4S)-N-hydroxy-1-methyl-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000025
(3S,4S)-N-hydroxy-1-methyl-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000016
(3S,4S)-N-hydroxy-3-[([4-[(2-methyl-1-benzofuran-3-yl)methyl]phenyl]carbonyl)amino]tetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
-
0.000006
(3S,4S)-N-hydroxy-3-[([4-[(2-methyl-1H-indol-3-yl)methyl]phenyl]carbonyl)amino]tetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
-
0.000001
(3S,4S)-N-hydroxy-3-[([4-[(2-methylimidazo[1,2-a]pyridin-3-yl)methyl]phenyl]carbonyl)amino]tetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
-
0.000001
(3S,4S)-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
Sus scrofa
-
-
0.000001
(3S,4S)-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]tetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
IC50 below 0.000001 mM
0.0000021
(3S,4S)-N-hydroxy-3-[[(4-[[2-(1-methylethyl)-1-benzofuran-3-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
-
0.0000032
(3S,4S)-N-hydroxy-3-[[(4-[[2-(1-methylethyl)imidazo[1,2-a]pyridin-3-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
-
0.0000017
(3S,4S)-N-hydroxy-3-[[(4-[[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
-
0.0000015
(3S,4S)-N-hydroxy-3-[[(4-[[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
-
0.000001
(3S,4S)-N-hydroxy-3-[[(4-[[2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]phenyl)carbonyl]amino]tetrahydro-2H-pyran-4-carboxamide
Sus scrofa
-
-
0.000001
(3S,4S)-N-hydroxy-4-[([4-[(2-methyl-1-benzofuran-3-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.000001
(3S,4S)-N-hydroxy-4-[([4-[(2-methyl-1H-indol-3-yl)methyl]phenyl]carbonyl)amino]-1-prop-2-yn-1-ylpyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000022
(3S,4S)-N-hydroxy-4-[([4-[(2-methyl-1H-indol-3-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000016
(3S,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1-phenylpyrrolidine-3-carboxamide
Sus scrofa
-
-
0.00000094
(3S,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1-prop-2-en-1-ylpyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000063
(3S,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000043
(3S,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]-1-prop-2-yn-1-ylpyrrolidine-3-carboxamide
Sus scrofa
-
-
0.000001
(3S,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000035
(3S,4S)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)oxy]phenyl]carbonyl)amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.0000018
(3S,4S)-N-hydroxy-4-[[(4-[[2-(1-methylethyl)-1-benzofuran-3-yl]methyl]phenyl)carbonyl]amino]pyrrolidine-3-carboxamide
Sus scrofa
-
-
0.00023
(5R,6R)-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,4-dioxo-1,3-diazaspiro[4.4]nonane-6-carboxamide
Sus scrofa
-
-
0.000064
(5R,6S)-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,4-dioxo-1,3-diazaspiro[4.4]nonane-6-carboxamide
Sus scrofa
-
-
0.000001
(5R,7S,8R)-N-hydroxy-8-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1-oxaspiro[4.4]nonane-7-carboxamide
Sus scrofa
-
-
0.000011
(5S,6R)-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,4-dioxo-1,3-diazaspiro[4.5]decane-6-carboxamide
Sus scrofa
-
-
0.000001
(5S,6S)-N-hydroxy-5-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-2,3,5,6-tetrahydro-4aH-cyclopenta[b][1,4]dioxine-6-carboxamide
Sus scrofa
-
-
0.000001
(5S,7S,8R)-N-hydroxy-8-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1-oxaspiro[4.4]nonane-7-carboxamide
Sus scrofa
-
-
0.000001
(7S,8R)-N-hydroxy-8-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1,4-dioxaspiro[4.4]nonane-7-carboxamide
Sus scrofa
-
-
0.0000015
1-methylethyl (3S,4S)-3-(hydroxycarbamoyl)-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-1-carboxylate
Sus scrofa
-
-
0.0073
1-[4-[(2-methylquinolin-4-yl)methoxy]benzyl]-1,3,5-triazinane-2,4,6-trione
Sus scrofa
-
IC50: 0.0073 mM
0.00015
13-[(4R)-2,5-dioxoimidazolidin-4-yl]-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]tridecanamide
Sus scrofa
-
-
0.000003
2,6-anhydro-3,4,5-trideoxy-1-(hydroxyamino)-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-D-threo-hexose
Sus scrofa
-
-
0.0074
2-[(5R,6R)-2,4-dioxo-1,3-diazaspiro[4.4]non-6-yl]-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]acetamide
Sus scrofa
-
-
0.000017
2-[(5R,6S)-2,4-dioxo-1,3-diazaspiro[4.4]non-6-yl]-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]acetamide
Sus scrofa
-
-
0.1
2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]acetamide
0.000138
4-[(2-methylquinolin-4-yl)methoxy]-N-(1,3,5-trioxo-2,4-diazaspiro[5.5]undec-7-yl)benzamide
0.1
4-[(2-methylquinolin-4-yl)methoxy]-N-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)benzamide
0.000044
4-[(2-methylquinolin-4-yl)methoxy]-N-(6,8,10-trioxo-2-oxa-7,9-diazaspiro[4.5]dec-4-yl)benzamide
0.000024
4-[(2-methylquinolin-4-yl)methoxy]-N-(6,8,10-trioxo-7,9-diazaspiro[4.5]dec-1-yl)benzamide
0.000031
4-[(2-methylquinolin-4-yl)methoxy]-N-([2,4,6-trioxo-5-[1-(tetrahydro-2H-pyran-2-yl)piperidin-4-yl]hexahydropyrimidin-5-yl]methyl)benzamide
Sus scrofa
-
-
0.000031
4-[(2-methylquinolin-4-yl)methoxy]-N-([2,4,6-trioxo-5-[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]hexahydropyrimidin-5-yl]methyl)benzamide
Sus scrofa
-
IC50: 0.000031 mM
0.00001
4-[(2-methylquinolin-4-yl)methoxy]-N-([2,4,6-trioxo-5-[4-(pyridin-3-ylcarbonyl)piperazin-1-yl]hexahydropyrimidin-5-yl]methyl)benzamide
Sus scrofa
-
IC50: 0.00001 mM
0.000029
4-[(2-methylquinolin-4-yl)methoxy]-N-([5-[1-(methylsulfonyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)benzamide
Sus scrofa
-
IC50: 0.000029 mM
0.000002
4-[(2-methylquinolin-4-yl)methoxy]-N-([5-[4-(methylsulfonyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)benzamide
Sus scrofa
-
IC50: 0.000002 mM
0.000018
4-[(2-methylquinolin-4-yl)methoxy]-N-[(2,4,6-trioxo-5-phenylhexahydropyrimidin-5-yl)methyl]benzamide
Sus scrofa
-
-
0.000055
4-[(2-methylquinolin-4-yl)methoxy]-N-[(2,4,6-trioxo-5-piperidin-4-ylhexahydropyrimidin-5-yl)methyl]benzamide
0.00236
4-[(2-methylquinolin-4-yl)methoxy]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)(pyridin-4-yl)methyl]benzamide
0.000026
4-[(2-methylquinolin-4-yl)methoxy]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]benzamide
0.000036
4-[(2-methylquinolin-4-yl)methoxy]-N-[2-(methylsulfonyl)-6,8,10-trioxo-2,7,9-triazaspiro[4.5]dec-4-yl]benzamide
Sus scrofa
-
IC50: 0.000036 mM
0.000029
4-[(2-methylquinolin-4-yl)methoxy]-N-[6,8,10-trioxo-2-(pyridin-3-ylcarbonyl)-2,7,9-triazaspiro[4.5]dec-4-yl]benzamide
Sus scrofa
-
IC50: 0.000029 mM
0.000014
4-[(2-methylquinolin-4-yl)methoxy]-N-[[2,4,6-trioxo-5-(4-phenylpiperazin-1-yl)hexahydropyrimidin-5-yl]methyl]benzamide
Sus scrofa
-
-
0.00062
5-(4-acetylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.00062 mM
0.000195
5-(4-benzylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.000195 mM
0.000081
5-(4-hexylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.000081 mM
0.000091
5-(4-methylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.000091 mM
0.049
5-methyl-5-(2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]ethyl)pyrimidine-2,4,6(1H,3H,5H)-trione
0.0008
5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-3-oxopropyl)pyrimidine-2,4,6(1H,3H,5H)-trione
0.011
5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.011 mM
0.1
5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]propyl)pyrimidine-2,4,6(1H,3H,5H)-trione
0.011
5-methyl-5-[(2E)-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]prop-2-en-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
-
0.0022
5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]benzyl]pyrimidine-2,4,6(1H,3H,5H)-trione
0.0013
5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenoxy]pyrimidine-2,4,6(1H,3H,5H)-trione
0.0037
5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]dihydropyrimidine-2,4(1H,3H)-dione
Sus scrofa
-
IC50: 0.0037 mM
0.00103
5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
0.000096
5-[4-(1-methylethyl)piperazin-1-yl]-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.000096 mM
0.00054
5-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.00054 mM
0.00016
5-[4-(2,2-dimethylpropyl)piperazin-1-yl]-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.00016 mM
0.000535
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-(pyridin-3-ylcarbonyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.000535 mM
0.0011
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-piperazin-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.0011 mM
0.000855
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-piperidin-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.000855 mM
0.000084
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(2-phenylethyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.000084 mM
0.00011
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(3-phenylpropyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.00011 mM
0.0028
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(4-nitrophenyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.0028 mM
0.000275
5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(methylsulfonyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione
Sus scrofa
-
IC50: 0.000275 mM
1
7-(1-methyl-2,5-dioxoimidazolidin-4-yl)-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]heptanamide
Sus scrofa
-
-
0.00021
7-(2,5-dioxoimidazolidin-4-yl)-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]heptanamide
Sus scrofa
-
-
1
7-(3-methyl-2,5-dioxoimidazolidin-4-yl)-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]heptanamide
Sus scrofa
-
-
0.00017
7-[(4R)-2,5-dioxoimidazolidin-4-yl]-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]heptanamide
Sus scrofa
-
-
0.0037
7-[(4S)-2,5-dioxoimidazolidin-4-yl]-N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]heptanamide
Sus scrofa
-
-
0.000001
methyl (3S,4S)-3-(hydroxycarbamoyl)-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]pyrrolidine-1-carboxylate
Sus scrofa
-
-
0.0000033
methyl (3S,4S)-3-(hydroxycarbamoyl)-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-1-carboxylate
Sus scrofa
-
-
0.0011
methyl (5R)-5-{7-[(3,5-diethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl}-6-(hydroxyamino)-6-oxohexanoate
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.0009
methyl (5R)-5-{7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl}-6-(hydroxyamino)-6-oxohexanoate
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.0047
methyl 4-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,5-dioxoimidazolidine-4-carboxylate
Sus scrofa
-
IC50: 0.0047 mM
0.000055
N-(2-acetyl-6,8,10-trioxo-2,7,9-triazaspiro[4.5]dec-4-yl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
IC50: 0.000055 mM
0.000055
N-(8-acetyl-1,3,5-trioxo-2,4,8-triazaspiro[5.5]undec-11-yl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.000052
N-([5-[1-(1-methylethyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
0.000013
N-([5-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
IC50: 0.000013 mM
0.000007
N-([5-[4-(1-methylethyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
0.000029
N-([5-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
IC50: 0.000029 mM
0.000062
N-([5-[4-(5-amino-8-carbamimidamido-4-oxooctyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.0029
N-hydroxy-2(R)-[7-(2,6-methylpyridyl-4-methyleneoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-propanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.00094
N-hydroxy-2(R)-[7-(3,5-dichlorobenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.0082
N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.0062
N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methoxycarbonylbutanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.0045
N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.0019
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine 1,1-dioxide]-6-N-(methanesulfonyl)hexylamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.004
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.0072
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methoxycarbonylbutanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.0054
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.00077
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.00047
N-hydroxy-2(R)-[7-(3-nitrophenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.0245
N-hydroxy-2(R)-[7-(4,5-dimethylthiazolyl-2-methyleneoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.0012
N-hydroxy-2(R)-[7-(4-nitrophenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.00084
N-hydroxy-2(R)-[7-(4-trifluoromethylphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.00035
N-hydroxy-2(R)-[7-benzyloxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentanamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.0095
N-hydroxy-2(R)-[7-hydroxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentamide
Sus scrofa
-
human peripheral blood mononuclear cell assay (PBMC)
0.000001
N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]tetrahydro-2H-pyran-3-carboxamide
Sus scrofa
-
-
0.0000018
N-[(1R,2S)-2-(hydroxycarbamoyl)-4-oxocyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.0002
N-[(1R,2S)-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.00000063
N-[(1R,2S)-4,4-difluoro-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.000001
N-[(1R,2S)-4-aziridin-1-yl-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
IC50 below 0.000001 mM
0.0000046
N-[(1R,2S)-4-hydroxy-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.000001
N-[(1S,2R)-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.000029
N-[(4-methyl-2,5-dioxoimidazolidin-4-yl)methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.000018
N-[(5-benzyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
IC50: 0.000018 mM
0.000016
N-[(5-ethyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
0.0009
N-[(5R,6R)-2,4-dioxo-1,3-diazaspiro[4.4]non-6-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.000024
N-[(5R,6R)-2,4-dioxo-1,3-diazaspiro[4.5]dec-6-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.0055
N-[(5R,6S)-2,4-dioxo-1,3-diazaspiro[4.4]non-6-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.000025
N-[(5R,9R)-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.000024
N-[(5R,9R)-7-(2-methylpropanoyl)-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.000028
N-[1-(2,5-dioxoimidazolidin-4-yl)ethyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.000097
N-[1-[2-(hydroxyamino)-2-oxoethyl]cyclohexyl]-4-[(2-methylquinolin-4-yl)methyl]benzamide
Sus scrofa
-
-
0.000111
N-[2-(2,2-dimethylpropanoyl)-6,8,10-trioxo-2,7,9-triazaspiro[4.5]dec-4-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
IC50: 0.000111 mM
0.000001
N-[2-(hydroxycarbamoyl)cyclobutyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.0000018
N-[2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methyl]benzamide
Sus scrofa
-
-
0.012
N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)acetamide
Sus scrofa
-
IC50: 0.012 mM
0.012
N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-3-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)propanamide
Sus scrofa
-
-
0.000002
N-[4-[2-(hydroxyamino)-2-oxoethyl]tetrahydrofuran-3-yl]-4-[(2-methylquinolin-4-yl)methyl]benzamide
Sus scrofa
-
-
0.000098
N-[[(4R)-2,5-dioxoimidazolidin-4-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
-
0.000019
N-[[5-(1-methylethyl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
0.000057
N-[[5-(1-methylpiperidin-4-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
0.000005
N-[[5-(4-acetylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
0.000014
N-[[5-(4-benzylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
IC50: 0.000014 mM
0.000062
N-[[5-(4-ethynylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
Sus scrofa
-
IC50: 0.000062 mM
0.000058
N-[[5-(4-methylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
0.000001
tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[([4-[(2-methylquinolin-4-yl)methyl]phenyl]carbonyl)amino]pyrrolidine-1-carboxylate
Sus scrofa
-
-
0.0000013
tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[([4-[(2-methylquinolin-4-yl)oxy]phenyl]carbonyl)amino]pyrrolidine-1-carboxylate
Sus scrofa
-
-
0.000013
tert-butyl (5-[[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]methyl]-2,4,6-trioxohexahydropyrimidin-5-yl)carbamate
0.000013
tert-butyl (5R,9R)-9-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7-carboxylate
Sus scrofa
-
-
0.000128
tert-butyl 11-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1,3,5-trioxo-2,4,8-triazaspiro[5.5]undecane-8-carboxylate
Sus scrofa
-
-
0.00016
tert-butyl 4-(5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,4,6-trioxohexahydropyrimidin-5-yl)piperazine-1-carboxylate
Sus scrofa
-
IC50: 0.00016 mM
0.000047
tert-butyl 4-(5-[[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]methyl]-2,4,6-trioxohexahydropyrimidin-5-yl)piperidine-1-carboxylate
0.000128
tert-butyl 4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-6,8,10-trioxo-2,7,9-triazaspiro[4.5]decane-2-carboxylate
Sus scrofa
-
IC50: 0.000128 mM
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
cellular suppression of TNF-alpha is measured using human whole blood (WBA) stimulated with lipopolysaccharide (LPS)
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
disintegrin and protease regions
-
Manually annotated by BRENDA team
-
membrane-bound
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ADA17_PIG
112
0
12201
Swiss-Prot
other Location (Reliability: 2)
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant TACE expressed in insect cells
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Becherer, J.D.; Lambert, M.H.; Andrews, R.C.
The tumor necrosis factor-alpha converting enzyme
Handbook of Experimental Pharmacology, (von der Helm, K. ; Korant, B. C. ; Cheronis, J. C. eds. )
140
235-258
2000
Homo sapiens, Mus musculus, Sus scrofa
-
Manually annotated by BRENDA team
Xue, C.B.; He, X.; Corbett, R.L.; Roderick, J.; Wasserman, Z.R.; Liu, R.Q.; Jaffee, B.D.; Covington, M.B.; Qian, M.; Trzaskos, J.M.; Newton, R.C.; Magolda, R.L.; Wexler, R.R.; Decicco, C.P.
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release
J. Med. Chem.
44
3351-3354
2001
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Flannery C.R.; Little C.B.; Caterson B.; Hughes C.E.
Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes
Matrix Biol.
18
225-237
1999
Sus scrofa (O77636), Sus scrofa
Manually annotated by BRENDA team
Duan, J.J.; Lu, Z.; Wasserman, Z.R.; Liu, R.; Covington, M.B.; Decicco, C.P.
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme
Bioorg. Med. Chem. Lett.
15
2970-2973
2005
Sus scrofa
Manually annotated by BRENDA team
Duan, J.J.; Chen, L.; Lu, Z.; Jiang, B.; Asakawa, N.; Sheppeck, J.E.; Liu, R.Q.; Covington, M.B.; Pitts, W.; Kim, S.H.; Decicco, C.P.
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
Bioorg. Med. Chem. Lett.
17
266-271
2006
Sus scrofa
Manually annotated by BRENDA team
Sheppeck, J.E.; Gilmore, J.L.; Yang, A.; Chen, X.; Xue, C.; Roderick, J.; Liu, R.; Covington, M.B.; Decicco, C.P.; Duan, J.J.
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
Bioorg. Med. Chem. Lett.
17
1413-1417
2007
Sus scrofa
Manually annotated by BRENDA team
Chen, X.; Ghavimi, B.; Corbett, R.L.; Xue, C.; Liu, R.; Covington, M.B.; Qian, M.; Vaddi, K.G.; Christ, D.D.; Hartman, K.D.; Ribadeneira, M.D.; Trzaskos, J.M.; Newton, R.C.; Decicco, C.P.; Duan, J.J.
A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1 group for the beta-amino hydroxamic acid derived TACE inhibitors
Bioorg. Med. Chem. Lett.
17
1865-1870
2007
Sus scrofa
Manually annotated by BRENDA team
Ott, G.R.; Asakawa, N.; Liu, R.; Covington, M.B.; Qian, M.; Vaddi, K.; Newton, R.C.; Trzaskos, J.M.; Christ, D.D.; Galya, L.; Scholz, T.; Marshall, W.; Duan, J.J.
alpha,beta-cyclic-beta-Benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
Bioorg. Med. Chem. Lett.
18
1288-1292
2008
Sus scrofa
Manually annotated by BRENDA team
Duan, J.J.; Chen, L.; Lu, Z.; Xue, C.; Liu, R.; Covington, M.B.; Qian, M.; Wasserman, Z.R.; Vaddi, K.; Christ, D.D.; Trzaskos, J.M.; Newton, R.C.; Decicco, C.P.
Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors
Bioorg. Med. Chem. Lett.
18
241-246
2008
Sus scrofa
Manually annotated by BRENDA team
Bandarage, U.K.; Wang, T.; Come, J.H.; Perola, E.; Wei, Y.; Rao, B.G.
Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones
Bioorg. Med. Chem. Lett.
18
44-48
2008
Sus scrofa
Manually annotated by BRENDA team
Lu, Z.; Ott, G.R.; Anand, R.; Liu, R.Q.; Covington, M.B.; Vaddi, K.; Qian, M.; Newton, R.C.; Christ, D.D.; Trzaskos, J.; Duan, J.J.
Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1 substituents
Bioorg. Med. Chem. Lett.
18
1958-1962
2008
Sus scrofa
Manually annotated by BRENDA team
Cherney, R.J.; Duan, J.J.; Voss, M.E.; Chen, L.; Wang, L.; Meyer,D.T.; Wasserman, Z.R.; Hardman, K.D.; Liu, R.Q.; Covington, M.B.; Qian, M.; Mandlekar, S.; Christ, D.; Trzaskos, J.M.; Newton, R.C.; Magolda, R.L.; Wexler, R.R.; Decicco, C.P.
Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors
J. Med. Chem.
46
1811-1823
2003
Sus scrofa
Manually annotated by BRENDA team