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Disease on EC 3.4.24.85 - S2P endopeptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-? 42 Production.
Conformational dynamics of transmembrane domain 3 of presenilin 1 is associated with the trimming activity of ?-secretase.
Highly efficient production of the Alzheimer's ?-Secretase integral membrane protease complex by a multi-gene stable integration approach.
Membrane trafficking and proteolytic activity of ?-secretase in Alzheimer's disease.
Novel {gamma}-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.
Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the ?-secretase.
Presenilin is the molecular target of acidic ?-secretase modulators in living cells.
Regulated intramembrane proteolysis: from the endoplasmic reticulum to the nucleus.
Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage.
Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.
Substrate specificity of gamma-secretase and other intramembrane proteases.
Arteriosclerosis
Not So Slim Anymore-Evidence for the Role of SUMO in the Regulation of Lipid Metabolism.
Atherosclerosis
Atheroprone flow activation of the sterol regulatory element binding protein 2 and nod-like receptor protein 3 inflammasome mediates focal atherosclerosis.
MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.
n-3 Fatty acids ameliorate hepatic steatosis and dysfunction after LXR agonist ingestion in mice.
Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility.
Brain Neoplasms
Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and is associated with altered genotype and patient survival in human brain tumors.
Carcinogenesis
Role of the Sterol Regulatory Element Binding Protein Pathway in Tumorigenesis.
Carcinoma, Hepatocellular
A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase.
Baicalin promoted site-2 protease and not site-1 protease in endoplasmic reticulum stress-induced apoptosis of human hepatocellular carcinoma cells.
I-CLIP: Improved Stratification of Advanced Hepatocellular Carcinoma Patients by Integrating Plasma IGF-1 into CLIP Score.
Cardiomyopathies
Phospholipid homeostasis and lipotoxic cardiomyopathy: A matter of balance.
Cholelithiasis
HNF1alpha and SREBP2 are important regulators of NPC1L1 in human liver.
Cholestasis
Not So Slim Anymore-Evidence for the Role of SUMO in the Regulation of Lipid Metabolism.
Choriocarcinoma
Luteolin Inhibits Proliferation and Induces Apoptosis of Human Placental Choriocarcinoma Cells by Blocking the PI3K/AKT Pathway and Regulating Sterol Regulatory Element Binding Protein Activity.
Cystadenoma
Estrogen-producing ovarian mucinous cystadenomas in postmenopausal women.
Cystadenoma, Mucinous
Estrogen-producing ovarian mucinous cystadenomas in postmenopausal women.
Cytomegalovirus Infections
Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1.
Diabetes Mellitus
[An association study of abdominal obesity and polymorphisms of UCP2 and SREBP1c genes]
Diabetes Mellitus, Type 2
[An association study of abdominal obesity and polymorphisms of UCP2 and SREBP1c genes]
Diabetic Nephropathies
Inhibition of SREBP with fatostatin does not attenuate early diabetic nephropathy in male mice.
Fatty Liver
Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs.
Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c.
Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Supplementation of Inulin with Various Degree of Polymerization Ameliorates Liver Injury and Gut Microbiota Dysbiosis in High Fat-Fed Obese Mice.
Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis.
Glioblastoma
Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and is associated with altered genotype and patient survival in human brain tumors.
Hepatitis C
Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.
Structural analysis of hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal peptide peptidase.
Hepatomegaly
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Herpes Simplex
The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator.
Hypercholesterolemia
Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha.
Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia.
Gender-related difference in altered gene expression of a sterol regulatory element binding protein, SREBP-2, by lead nitrate in rats: correlation with development of hypercholesterolemia.
Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment.
SREBP?2 expression pattern contributes to susceptibility of Mongolian gerbils to hypercholesterolemia.
Hyperlipidemias
Antiatherosclerotic effect of farnesoid X receptor.
Hyperlipoproteinemia Type II
Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment.
Hypertension
Roles of Dietary Bioactive Peptides in Redox Balance and Metabolic Disorders.
Hypertriglyceridemia
Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha.
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Hypoglycemia
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Hypotension
Indinavir inhibits the expression of cytoplasmic aromatase and nuclear SREBP in the hippocampus of reperfusion injury-induced ischemic rats.
Infections
ChREBP, a glucose-responsive transcriptional factor, enhances glucose metabolism to support biosynthesis in human cytomegalovirus-infected cells.
Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus.
Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma.
Hepatitis C and hepatic steatosis.
Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.
Insulin Resistance
A rare missense mutation in a type 2 diabetes patient decreases the transcriptional activity of human sterol regulatory element binding protein-1.
Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs.
The 1975 type Japanese diet improves the gut microbial flora and inhibits visceral fat accumulation in mice.
The tacrolimus-induced glucose homeostasis imbalance in terms of the liver: From bench to bedside.
Leukemia
Multilocus genotypic association with vascular dementia by multifactor dimensionality reduction and entropy-based estimation.
Lipodystrophy
Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins.
Liposarcoma
Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer.
Liver Diseases
Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c.
Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis.
Metabolic Diseases
Berberine activates AMPK to suppress proteolytic processing, nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytes.
Nasopharyngeal Carcinoma
Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase.
Neoplasm Metastasis
SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity.
Neoplasms
A mixture of the aqueous extract of Garcinia cambogia, soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet.
Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development.
Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells.
Attenuation of Endoplasmic Reticulum Stress-Mediated Liver Damage by Mulberry Leaf Diet in Streptozotocin-Induced Diabetic Rats.
Effects of dietary energy on antioxidant capacity, glucose-lipid metabolism and meat fatty acid profile of Holstein bulls at different ages.
Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD).
Estrogen-producing ovarian mucinous cystadenomas in postmenopausal women.
Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.
High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer.
Highly efficient production of the Alzheimer's ?-Secretase integral membrane protease complex by a multi-gene stable integration approach.
Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2.
Inhibition of ?-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.
Lipid Regulatory Proteins as Potential Therapeutic Targets for Ovarian Cancer in Obese Women.
MicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancers.
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation.
Platyphylloside Isolated From Betula platyphylla Inhibit Adipocyte Differentiation and Induce Lipolysis Via Regulating Adipokines Including PPAR? in 3T3-L1 Cells.
SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis.
SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma.
Unliganded thyroid hormone receptor-beta1 represses liver X receptor alpha/oxysterol-dependent transactivation.
Nephrotic Syndrome
Hepatic tissue sterol regulatory element binding protein 2 and low-density lipoprotein receptor in nephrotic syndrome.
Neuroblastoma
Abeta((25-35)) Attenuated SREBP Level in Nuclear Extracts of Serum-Deprived Human Neuroblastoma Cells.
Dysregulation of SREBP2 induces BACE1 expression.
U18666A, an activator of sterol regulatory element binding protein pathway, modulates presynaptic dopaminergic phenotype of SH-SY5Y neuroblastoma cells.
Non-alcoholic Fatty Liver Disease
Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD).
Evaluation of Fbxw7 expression and its correlation with expression of SREBP-1 in a mouse model of NAFLD.
Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c.
Not So Slim Anymore-Evidence for the Role of SUMO in the Regulation of Lipid Metabolism.
Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Regulation of SREBP-2 intracellular trafficking improves impaired autophagic flux and alleviates endoplasmic reticulum stress in NAFLD.
Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis.
Obesity
Dietary cholesterol interacts with SREBF1 to modulate obesity in Chinese children.
Endocannabinoid system in cancer cachexia.
Genetic variations in sterol regulatory element binding protein cleavage-activating protein (SCAP) are associated with blood pressure in overweight/obese Chinese children.
Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people.
Roles of Dietary Bioactive Peptides in Redox Balance and Metabolic Disorders.
Sterol regulatory element binding protein 1c (SREBP-1c) expression in human obesity.
[Association of rs2228314 polymorphism in SREBP2 with serum lipid levels and obesity among children and adolescents].
Obesity, Abdominal
[An association study of abdominal obesity and polymorphisms of UCP2 and SREBP1c genes]
Paralysis
Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis.
Prostatic Neoplasms
Nelfinavir and nelfinavir analogs block site-2 protease cleavage to inhibit castration-resistant prostate cancer.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1.
Starvation
Genetically Based Physiological Responses to Overwinter Starvation in Gibel Carp (Carassius gibelio).
Iron - A Key Nexus in the Virulence of Aspergillus fumigatus.
Stroke
Elevated sterol regulatory elementary binding protein 1 and GluA2 levels in the hippocampal nuclear fraction of Genetic Absence Epilepsy Rats from Strasbourg.
Tics
Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.
Tuberculosis
M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates.