Reference on EC 3.4.24.81 - ADAM10 endopeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vincent, B.; Paitel, E.; Saftig, P.; Frobert, Y.; Hartmann, D.; De Strooper, B.; Grassi, J.; Lopez-Perez, E.; Checler, F.
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein
J. Biol. Chem.
276
37743-37746
2001
BRENDA: Homo sapiens, Mus musculus
Textmining: prion
Flannery C.R.; Little C.B.; Caterson B.; Hughes C.E.
Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes
Matrix Biol.
18
225-237
1999
Bos taurus, Homo sapiens, Sus scrofa, Sus scrofa (O77636)
Lopez-Perez, E.; Zhang, Y.; Frank, S.J.; Creemers, J.; Seidah, N.; Checler, F.
Constitutive a-secretase cleavage of the b-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10
J. Neurochem.
76
1532-1539
2001
Homo sapiens
Anders, A.; Gilbert, S.; Garten, W.; Postina, R.; Fahrenholz, F.
Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases
FASEB J.
15
1837-1839
2001
Bos taurus, Homo sapiens
Lemjabbar, H.; Basbaum, C.
Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells
Nat. Med.
8
41-46
2002
BRENDA: Homo sapiens
Textmining: Staphylococcus aureus
Gutwein, P.; Mechtersheimer, S.; Riedle, S.; Stoeck, A.; Gast, D.; Joumaa, S.; Zentgraf, H.; Fogel, M.; Altevogt, P.
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles
FASEB J.
17
292-294
2003
Homo sapiens
Asai, M.; Hattori, C.; Szabo, B.; Sasagawa, N.; Maruyama, K.; Tanuma, S.I.; Ishiura, S.
Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase
Biochem. Biophys. Res. Commun.
301
231-235
2003
Homo sapiens
Gatta, L.B.; Albertini, A.; Ravid, R.; Finazzi, D.
Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus
NeuroReport
13
2031-2033
2002
BRENDA: Homo sapiens
Textmining: Hippocampus
Colciaghi, F.; Borroni, B.; Pastorino, L.; Marcello, E.; Zimmermann, M.; Cattabeni, F.; Padovani, A.; Di Luca, M.
alpha-secretase ADAM10 as well as aAPPs is reduced in platelets and CSF of Alzheimer Disease patients
Mol. Med.
8
67-74
2002
Homo sapiens
Yan, Y.; Shirakabe, K.; Werb, Z.
The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors
J. Cell Biol.
158
221-226
2002
BRENDA: Chlorocebus aethiops, Homo sapiens
Textmining: Drosophila
Vankemmelbeke, M.N.; Jones, G.C.; Fowles, C.; Ilic, M.Z.; Handley, C.J.; Day, A.J.; Knight, C.G.; Mort, J.S.; Buttle, D.J.
Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters
Eur. J. Biochem.
270
2394-2403
2003
Camellia sinensis, Homo sapiens, Homo sapiens (Q9UHI8), Homo sapiens (Q9UNA0)
Murai, T.; Miyauchi, T.; Yanagida, T.; Sako, Y.
Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10
Biochem. J.
395
65-71
2006
Homo sapiens
Janes, P.W.; Saha, N.; Barton, W.A.; Kolev, M.V.; Wimmer-Kleikamp, S.H.; Nievergall, E.; Blobel, C.P.; Himanen, J.P.; Lackmann, M.; Nikolov, D.B.
Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans
Cell
123
291-304
2005
Bos taurus
McCulloch, D.R.; Akl, P.; Samaratunga, H.; Herington, A.C.; Odorico, D.M.
Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP
Clin. Cancer Res.
10
314-323
2004
Homo sapiens
Ludwig, A.; Hundhausen, C.; Lambert, M.H.; Broadway, N.; Andrews, R.C.; Bickett, D.M.; Leesnitzer, M.A.; Becherer, J.D.
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules
Comb. Chem. High Throughput Screen.
8
161-171
2005
Homo sapiens
Asayesh, A.; Alanentalo, T.; Khoo, N.K.; Ahlgren, U.
Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments
Dev. Dyn.
232
1105-1114
2005
Mus musculus
Reiss, K.; Maretzky, T.; Ludwig, A.; Tousseyn, T.; de Strooper, B.; Hartmann, D.; Saftig, P.
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling
EMBO J.
24
742-752
2005
Mus musculus
Allinson, T.M.; Parkin, E.T.; Condon, T.P.; Schwager, S.L.; Sturrock, E.D.; Turner, A.J.; Hooper, N.M.
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein
Eur. J. Biochem.
271
2539-2547
2004
Homo sapiens
Budagian, V.; Bulanova, E.; Orinska, Z.; Ludwig, A.; Rose-John, S.; Saftig, P.; Borden, E.C.; Bulfone-Paus, S.
Natural soluble interleukin-15Ra is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17)
J. Biol. Chem.
279
40368-40375
2004
Mus musculus, Mus sp.
Sanderson, M.P.; Erickson, S.N.; Gough, P.J.; Garton, K.J.; Wille, P.T.; Raines, E.W.; Dunbar, A.J.; Dempsey, P.J.
ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx
J. Biol. Chem.
280
1826-1837
2005
BRENDA: Mus musculus
Textmining: Mus sp.
Obregon, D.F.; Rezai-Zadeh, K.; Bai, Y.; Sun, N.; Hou, H.; Ehrhart, J.; Zeng, J.; Mori, T.; Arendash, G.W.; Shytle, D.; Town, T.; Tan, J.
ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced a-secretase cleavage of amyloid precursor protein
J. Biol. Chem.
281
16419-16427
2006
BRENDA: Mus musculus
Textmining: Camellia sinensis, Homo sapiens
Reiss, K.; Maretzky, T.; Haas, I.G.; Schulte, M.; Ludwig, A.; Frank, M.; Saftig, P.
Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion
J. Biol. Chem.
281
21735-21744
2006
Mus musculus
Zimmermann, M.; Gardoni, F.; Marcello, E.; Colciaghi, F.; Borroni, B.; Padovani, A.; Cattabeni, F.; Di Luca, M.
Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines
J. Neurochem.
90
1489-1499
2004
Homo sapiens
Bandyopadhyay, S.; Hartley, D.M.; Cahill, C.M.; Lahiri, D.K.; Chattopadhyay, N.; Rogers, J.T.
Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase
J. Neurosci. Res.
84
106-118
2006
Homo sapiens
Budagian, V.; Bulanova, E.; Orinska, Z.; Duitman, E.; Brandt, K.; Ludwig, A.; Hartmann, D.; Lemke, G.; Saftig, P.; Bulfone-Paus, S.
Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum
Mol. Cell. Biol.
25
9324-9339
2005
BRENDA: Mus musculus
Textmining: Mus sp.
Anders, L.; Mertins, P.; Lammich, S.; Murgia, M.; Hartmann, D.; Saftig, P.; Haass, C.; Ullrich, A.
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenins transcriptional activity
Mol. Cell. Biol.
26
3917-3934
2006
Mus musculus
Uemura, K.; Kihara, T.; Kuzuya, A.; Okawa, K.; Nishimoto, T.; Ninomiya, H.; Sugimoto, H.; Kinoshita, A.; Shimohama, S.
Characterization of sequential N-cadherin cleavage by ADAM10 and PS1
Neurosci. Lett.
402
278-283
2006
Homo sapiens
Maretzky, T.; Reiss, K.; Ludwig, A.; Buchholz, J.; Scholz, F.; Proksch, E.; de Strooper, B.; Hartmann, D.; Saftig, P.
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation
Proc. Natl. Acad. Sci. USA
102
9182-9187
2005
Homo sapiens, Mus musculus
Schramme, A.; Abdel-Bakky, M.S.; Kaempfer-Kolb, N.; Pfeilschifter, J.; Gutwein, P.
The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells
Biochem. Biophys. Res. Commun.
370
311-316
2008
Homo sapiens
Ko, S.; Lin, S.; Wong, Y.; Liu, C.; Chang, K.; Liu, T.
Increase of disintegrin and metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma
Cancer Lett.
245
33-43
2007
Homo sapiens
Gavert, N.; Sheffer, M.; Raveh, S.; Spaderna, S.; Shtutman, M.; Brabletz, T.; Barany, F.; Paty, P.; Notterman, D.; Domany, E.; Ben-Zeev, A.
Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis
Cancer Res.
67
7703-7712
2007
BRENDA: Homo sapiens
Textmining: Mus sp.
Smith, C.; Halvorsen, B.; Otterdal, K.; Waehre, T.; Yndestad, A.; Fevang, B.; Sandberg, W.J.; Breland, U.M.; Froland, S.S.; Oie, E.; Gullestad, L.; Damas, J.K.; Aukrust, P.
High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins
Cardiovasc. Res.
79
195-203
2008
Homo sapiens
Schulte, M.; Reiss, K.; Lettau, M.; Maretzky, T.; Ludwig, A.; Hartmann, D.; de Strooper, B.; Janssen, O.; Saftig, P.
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death
Cell Death Differ.
14
1040-1049
2007
BRENDA: Homo sapiens
Textmining: Mus musculus
Conrad, D.H.; Ford, J.W.; Sturgill, J.L.; Gibb, D.R.
CD23: an overlooked regulator of allergic disease
Curr. Allergy Asthma Rep.
7
331-337
2007
Homo sapiens
Deuss, M.; Reiss, K.; Hartmann, D.
Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17
Curr. Alzheimer Res.
5
187-201
2008
BRENDA: Drosophila melanogaster, Mus musculus
Textmining: Mus sp.
Hakulinen, J.; Keski-Oja, J.
ADAM10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells
J. Biol. Chem.
281
21369-21376
2006
Homo sapiens
Lemieux, G.A.; Blumenkron, F.; Yeung, N.; Zhou, P.; Williams, J.; Grammer, A.C.; Petrovich, R.; Lipsky, P.E.; Moss, M.L.; Werb, Z.
The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10
J. Biol. Chem.
282
14836-14844
2007
Homo sapiens
Moss, M.L.; Bomar, M.; Liu, Q.; Sage, H.; Dempsey, P.; Lenhart, P.M.; Gillispie, P.A.; Stoeck, A.; Wildeboer, D.; Bartsch, J.W.; Palmisano, R.; Zhou, P.
The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events
J. Biol. Chem.
282
35712-35721
2007
BRENDA: Mus musculus
Textmining: Escherichia coli, Homo sapiens
Martin, L.; Fluhrer, R.; Reiss, K.; Kremmer, E.; Saftig, P.; Haass, C.
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b
J. Biol. Chem.
283
1644-1652
2008
Homo sapiens
Kaczur, V.; Puskas, L.G.; Nagy, Z.U.; Miled, N.; Rebai, A.; Juhasz, F.; Kupihar, Z.; Zvara, A.; Hackler, L.J.; Farid, N.R.
Cleavage of human thyrotropin receptor by ADAM10 is regulated by thyrotropin
J. Mol. Recognit.
20
392-404
2007
BRENDA: Homo sapiens (O14672), Homo sapiens
Textmining: insertion sequences
Albrecht, S.; Wang, S.; Holz, A.; Bergter, A.; Paululat, A.
The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster
Mech. Dev.
123
372-387
2006
BRENDA: Drosophila melanogaster, Drosophila melanogaster Oregon R
Textmining: Drosophila
Dehmel, T.; Janke, A.; Hartung, H.P.; Goebel, H.H.; Wiendl, H.; Kieseier, B.C.
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies
Neurobiol. Dis.
25
665-674
2007
Homo sapiens
Clement, A.B.; Hanstein, R.; Schroeder, A.; Nagel, H.; Endres, K.; Fahrenholz, F.; Behl, C.
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress
Neuroscience
152
459-468
2008
BRENDA: Mus musculus
Textmining: Homo sapiens, Mus sp.
Chen, C.D.; Podvin, S.; Gillespie, E.; Leeman, S.E.; Abraham, C.R.
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
Proc. Natl. Acad. Sci. USA
104
19796-19801
2007
Homo sapiens
Rapti, M.; Atkinson, S.J.; Lee, M.H.; Trim, A.; Moss, M.; Murphy, G.
The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition
Biochem. J.
411
433-439
2008
Homo sapiens
Escrevente, C.; Morais, V.A.; Keller, S.; Soares, C.M.; Altevogt, P.; Costa, J.
Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme
Biochim. Biophys. Acta
1780
905-913
2008
Bos taurus, Homo sapiens
Esselens, C.W.; Malapeira, J.; Colome, N.; Moss, M.; Canals, F.; Arribas, J.
Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17
Biol. Chem.
389
1075-1084
2008
Homo sapiens
Prinzen, C.; Truembach, D.; Wurst, W.; Endres, K.; Postina, R.; Fahrenholz, F.
Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
BMC Genomics
10
66
2009
BRENDA: Bos taurus
Textmining: Mus musculus, Homo sapiens, Mus sp.
Schulz, B.; Pruessmeyer, J.; Maretzky, T.; Ludwig, A.; Blobel, C.P.; Saftig, P.; Reiss, K.
ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin
Circ. Res.
102
1192-1201
2008
Homo sapiens
Raucci, A.; Cugusi, S.; Antonelli, A.; Barabino, S.M.; Monti, L.; Bierhaus, A.; Reiss, K.; Saftig, P.; Bianchi, M.E.
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
FASEB J.
22
3716-3727
2008
Homo sapiens, Mus musculus
Freese, C.; Garratt, A.N.; Fahrenholz, F.; Endres, K.
The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1
FEBS J.
276
1568-1580
2009
BRENDA: Homo sapiens, Mus musculus
Textmining: Mus sp., Metazoa
Oh, S.T.; Schramme, A.; Stark, A.; Tilgen, W.; Gutwein, P.; Reichrath, J.
The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas
J. Cutan. Pathol.
36
395-401
2009
BRENDA: Homo sapiens
Textmining: Areas
Arduise, C.; Abache, T.; Li, L.; Billard, M.; Chabanon, A.; Ludwig, A.; Mauduit, P.; Boucheix, C.; Rubinstein, E.; Le Naour, F.
Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor
J. Immunol.
181
7002-7013
2008
Homo sapiens
Parkin, E.; Harris, B.
A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10
J. Neurochem.
108
1464-1479
2009
Homo sapiens
Kohutek, Z.A.; diPierro, C.G.; Redpath, G.T.; Hussaini, I.M.
ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration
J. Neurosci.
29
4605-4615
2009
Mus musculus
Dehmel, T.; Goebel, H.H.; Hartung, H.P.; Lehmann, H.; Wiendl, H.; Kieseier, B.C.
The metalloproteinase-disintegrin ADAM10 is exclusively expressed by type I muscle fibers
Muscle Nerve
38
1049-1051
2008
Homo sapiens
Qin, W.; Ho, L.; Wang, J.; Peskind, E.; Pasinetti, G.M.
S100A7, a novel Alzheimers disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10
PLoS ONE
4
e4183
2009
BRENDA: Homo sapiens
Textmining: Mus musculus
Riedle, S.; Kiefel, H.; Gast, D.; Bondong, S.; Wolterink, S.; Gutwein, P.; Altevogt, P.
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity
Biochem. J.
420
391-402
2009
BRENDA: Homo sapiens
Textmining: Mus musculus
Caescu, C.I.; Jeschke, G.R.; Turk, B.E.
Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10
Biochem. J.
424
79-88
2009
Mus musculus
Dittmer, A.; Hohlfeld, K.; Luetzkendorf, J.; Mueller, L.P.; Dittmer, J.
Human mesenchymal stem cells induce E-cadherin degradation in breast carcinoma spheroids by activating ADAM10
Cell. Mol. Life Sci.
66
3053-3065
2009
Homo sapiens
Mezyk-Kopec R.; Bzowska, M.; Stalinska, K.; Chelmicki, T.; Podkalicki, M.; Jucha, J.; Kowalczyk, K.; Mak, P.; Bereta, J.
Identification of ADAM10 as a major TNF sheddase in ADAM17-deficient fibroblasts
Cytokine
46
309-315
2009
Mus musculus
Oh, S.T.; Cho, B.K.; Schramme, A.; Gutwein, P.; Tilgen, W.; Reichrath, J.
Hair-cycle dependent differential expression of ADAM 10 and ADAM 12: An immunohistochemical analysis in human hair follicles in situ
Dermatoendocrinol.
1
46-53
2009
Homo sapiens
Tippmann, F.; Hundt, J.; Schneider, A.; Endres, K.; Fahrenholz, F.
Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin
FASEB J.
23
1643-1654
2009
BRENDA: Homo sapiens
Textmining: Mus musculus
Xu, D.; Sharma, C.; Hemler, M.E.
Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein
FASEB J.
23
3674-3681
2009
Homo sapiens
Endres, K.; Fahrenholz, F.
Upregulation of the alpha-secretase ADAM10--risk or reason for hope?
FEBS J.
277
1585-1596
2010
BRENDA: Homo sapiens, Mus musculus
Textmining: animal
Kim, M.; Suh, J.; Romano, D.; Truong, M.H.; Mullin, K.; Hooli, B.; Norton, D.; Tesco, G.; Elliott, K.; Wagner, S.L.; Moir, R.D.; Becker, K.D.; Tanzi, R.E.
Potential late-onset Alzheimers disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity
Hum. Mol. Genet.
18
3987-3996
2009
Homo sapiens
Peng, M.; Guo, S.; Yin, N.; Xue, J.; Shen, L.; Zhao, Q.; Zhang, W.
Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17
Immunology
130
83-91
2010
BRENDA: Homo sapiens
Textmining: Mus musculus
Tousseyn, T.; Thathiah, A.; Jorissen, E.; Raemaekers, T.; Konietzko, U.; Reiss, K.; Maes, E.; Snellinx, A.; Serneels, L.; Nyabi, O.; Annaert, W.; Saftig, P.; Hartmann, D.; De Strooper, B.
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase
J. Biol. Chem.
284
11738-11747
2009
Mus musculus (O35598)
Franzke, C.W.; Bruckner-Tuderman, L.; Blobel, C.P.
Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9
J. Biol. Chem.
284
23386-23396
2009
BRENDA: Mus musculus
Textmining: Mus sp.
van Tetering, G.; van Diest, P.; Verlaan, I.; van der Wall, E.; Kopan, R.; Vooijs, M.
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage
J. Biol. Chem.
284
31018-31027
2009
BRENDA: Mus musculus
Textmining: Homo sapiens
Marcello, E.; Gardoni, F.; Di Luca, M.; Perez-Otano, I.
An arginine stretch limits ADAM10 exit from the endoplasmic reticulum
J. Biol. Chem.
285
10376-10384
2010
Mus musculus
Ratchford, A.M.; Baker, O.J.; Camden, J.M.; Rikka, S.; Petris, M.J.; Seye, C.I.; Erb, L.; Weisman, G.A.
P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells
J. Biol. Chem.
285
7545-7555
2010
Homo sapiens
Jorissen, E.; Prox, J.; Bernreuther, C.; Weber, S.; Schwanbeck, R.; Serneels, L.; Snellinx, A.; Craessaerts, K.; Thathiah, A.; Tesseur, I.; Bartsch, U.; Weskamp, G.; Blobel, C.P.; Glatzel, M.; De Strooper, B.; Saftig, P.
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex
J. Neurosci.
30
4833-4844
2010
BRENDA: Mus musculus
Textmining: Mus sp.
Le Gall, S.M.; Bobe, P.; Reiss, K.; Horiuchi, K.; Niu, X.D.; Lundell, D.; Gibb, D.R.; Conrad, D.; Saftig, P.; Blobel, C.P.
ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha
Mol. Biol. Cell
20
1785-1794
2009
Mus musculus
Bozkulak, E.C.; Weinmaster, G.
Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling
Mol. Cell. Biol.
29
5679-5695
2009
Mus musculus
Endres, K.; Mitteregger, G.; Kojro, E.; Kretzschmar, H.; Fahrenholz, F.
Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo
Neurobiol. Dis.
36
233-241
2009
BRENDA: Mus musculus
Textmining: prion, Mus sp.
Janes, P.W.; Wimmer-Kleikamp, S.H.; Frangakis, A.S.; Treble, K.; Griesshaber, B.; Sabet, O.; Grabenbauer, M.; Ting, A.Y.; Saftig, P.; Bastiaens, P.I.; Lackmann, M.
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10
PLoS Biol.
7
e1000215
2009
BRENDA: Mus musculus
Textmining: Electron
Oh, S.T.; Cho, B.K.; Schramme, A.; Gutwein, P.; Tilgen, W.; Reichrath, J.
Hair-cycle dependent differential expression of ADAM 10 and ADAM 12: An immunohistochemical analysis in human hair follicles in situ
Dermato-endocrinology
1
46-53
2009
Homo sapiens
Bloch, L.; Sineshchekova, O.; Reichenbach, D.; Reiss, K.; Saftig, P.; Kuro-o, M.; Kaether, C.
Klotho is a substrate for alpha-, beta- and gamma-secretase
FEBS Lett.
583
3221-3224
2009
Mus sp.
Kojro, E.; Fueger, P.; Prinzen, C.; Kanarek, A.M.; Rat, D.; Endres, K.; Fahrenholz, F.; Postina, R.
Statins and the squalene Ssnthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis
J. Alzheimers Dis.
20
1215-1231
2010
Homo sapiens
Jacobsen, K.T.; Adlerz, L.; Multhaup, G.; Iverfeldt, K.
Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases
J. Biol. Chem.
285
10223-10231
2010
Homo sapiens
Liu, Q.; Zhang, J.; Tran, H.; Verbeek, M.; Reiss, K.; Estus, S.; Bu, G.
LRP1 shedding in human brain: Roles of ADAM10 and ADAM17
Mol. Neurodegener.
4
17
2009
Homo sapiens
Endres, K.; Fahrenholz, F.
Regulation of alpha-secretase ADAM10 expression and activity
Exp. Brain Res.
2011
1-10
2011
Homo sapiens
-
Kim, J.; Lilliehook, C.; Dudak, A.; Prox, J.; Saftig, P.; Federoff, H.J.; Lim, S.T.
Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10)
J. Biol. Chem.
285
22919-22926
2010
Mus musculus
Garbers, C.; Jaenner, N.; Chalaris, A.; Moss, M.L.; Floss, D.M.; Meyer, D.; Koch-Nolte, F.; Rose-John, S.; Scheller, J.
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding
J. Biol. Chem.
286
14804-14811
2011
BRENDA: Mus musculus
Textmining: Homo sapiens, Mus sp.
Bouillot, S.; Tillet, E.; Carmona, G.; Prandini, M.H.; Gauchez, A.S.; Hoffmann, P.; Alfaidy, N.; Cand, F.; Huber, P.
Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia
J. Biol. Chem.
286
15195-15204
2011
BRENDA: Homo sapiens
Textmining: Mus musculus, Mus sp.
Gibb, D.R.; El Shikh, M.; Kang, D.J.; Rowe, W.J.; El Sayed, R.; Cichy, J.; Yagita, H.; Tew, J.G.; Dempsey, P.J.; Crawford, H.C.; Conrad, D.H.
ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo
J. Exp. Med.
207
623-635
2010
BRENDA: Mus musculus
Textmining: Mus sp., Drosophila
Chaimowitz, N.S.; Martin, R.K.; Cichy, J.; Gibb, D.R.; Patil, P.; Kang, D.J.; Farnsworth, J.; Butcher, E.C.; McCright, B.; Conrad, D.H.
A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture
J. Immunol.
187
5114-5122
2011
BRENDA: Mus musculus
Textmining: Mus sp.
Blume, K.E.; Soeroes, S.; Keppeler, H.; Stevanovic, S.; Kretschmer, D.; Rautenberg, M.; Wesselborg, S.; Lauber, K.
Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic find-me signal
J. Immunol.
188
135-145
2012
Homo sapiens
Malinverno, M.; Carta, M.; Epis, R.; Marcello, E.; Verpelli, C.; Cattabeni, F.; Sala, C.; Mulle, C.; Di Luca, M.; Gardoni, F.
Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage
J. Neurosci.
30
16343-16355
2010
Mus musculus
Solanas, G.; Cortina, C.; Sevillano, M.; Batlle, E.
Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling
Nat. Cell Biol.
13
1100-1107
2011
BRENDA: Canis lupus familiaris
Textmining: Mus sp.
Hogl, S.; Kuhn, P.H.; Colombo, A.; Lichtenthaler, S.F.
Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase
PLoS ONE
6
e21337
2011
BRENDA: Homo sapiens
Textmining: Mus musculus
Li, B.; Yu, D.; Xu, Z.
Activated protein C inhibits amyloid beta production via promoting expression of ADAM-10
Brain Res.
1545
35-44
2014
Mus sp.
Nagara, Y.; Hagiyama, M.; Hatano, N.; Futai, E.; Suo, S.; Takaoka, Y.; Murakami, Y.; Ito, A.; Ishiura, S.
Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by gamma-secretase complex
Biochem. Biophys. Res. Commun.
417
462-467
2012
Homo sapiens (O14672)
Pabois, A.; Devalliere, J.; Quillard, T.; Coulon, F.; Gerard, N.; Laboisse, C.; Toquet, C.; Charreau, B.
The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells
Biochem. Pharmacol.
91
510-521
2014
BRENDA: Homo sapiens (O14672), Homo sapiens
Textmining: Areas
Wang, Y.; Wu, J.; Newton, R.; Bahaie, N.; Long, C.; Walcheck, B.
ADAM17 cleaves CD16b (FcgammaRIIIb) in human neutrophils
Biochim. Biophys. Acta
1833
680-685
2013
Homo sapiens, Homo sapiens (P78536)
Urriola-Munoz, P.; Lizama, C.; Lagos-Cabre, R.; Reyes, J.; Moreno, R.
Differential expression and localization of ADAM10 and ADAM17 during rat spermatogenesis suggest a role in germ cell differentiation
Biol. Res.
47
31
2014
BRENDA: Rattus norvegicus (Q10743)
Textmining: Rattus
Musumeci, G.; Magro, G.; Cardile, V.; Coco, M.; Marzagalli, R.; Castrogiovanni, P.; Imbesi, R.; Graziano, A.; Barone, F.; Di Rosa, M.; Castorina, S.; Castorina, A.
Characterization of matrix metalloproteinase-2 and -9, ADAM-10 and N-cadherin expression in human glioblastoma multiforme
Cell Tissue Res.
362
45-60
2015
Homo sapiens, Homo sapiens (P08253), Homo sapiens (P14780)
Tsai, Y.; Vandussen, K.; Sawey, E.; Wade, A.; Kasper, C.; Rakshit, S.; Bhatt, R.; Stoeck, A.; Maillard, I.; Crawford, H.; Samuelson, L.; Dempsey, P.
ADAM10 regulates notch function in intestinal stem cells of mice
Gastroenterology
147
822-834.e13
2014
BRENDA: Mus musculus
Textmining: Mus sp.
Li, Y.; Fan, Y.; Tang, J.; Li, J.; Yu, C.
Meprin-beta regulates production of pro-inflammatory factors via a disintegrin and metalloproteinase-10 (ADAM-10) dependent pathway in macrophages
Int. Immunopharmacol.
18
77-84
2014
Homo sapiens, Homo sapiens (Q16820)
Guo, Q.; Wang, Y.; Tripathi, P.; Manda, K.; Mukherjee, M.; Chaklader, M.; Austin, P.; Surendran, K.; Chen, F.
Adam10 mediates the choice between principal cells and intercalated cells in the kidney
J. Am. Soc. Nephrol.
26
149-159
2015
BRENDA: Mus musculus
Textmining: Mus sp.
Breshears, L.M.; Schlievert, P.M.; Peterson, M.L.
A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1)
J. Biol. Chem.
287
32578-32587
2012
Homo sapiens (O14672), Homo sapiens
Minond, D.; Cudic, M.; Bionda, N.; Giulianotti, M.; Maida, L.; Houghten, R.; Fields, G.
Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates
J. Biol. Chem.
287
36473-36487
2012
Homo sapiens (O14672)
Herzog, C.; Haun, R.S.; Ludwig, A.; Shah, S.V.; Kaushal, G.P.
ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A
J. Biol. Chem.
289
13308-13322
2014
Mus musculus (O35598)
Powers, M.; Kim, H.; Wang, Y.; Wardenburg, J.
ADAM10 mediates vascular injury induced by Staphylococcus aureus alpha-hemolysin
J. Infect. Dis.
206
352-356
2012
BRENDA: Mus musculus (O35598), Mus musculus
Textmining: Staphylococcus aureus
Hofmann, S.; Vögtle, T.; Bender, M.; Rose-John, S.; Nieswandt, B.
The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets
J. Thromb. Haemost.
10
2581-2592
2012
BRENDA: Homo sapiens (O14672), Mus musculus (O35598)
Textmining: Thrombus
Shitomi, Y.; Thogersen, I.; Ito, N.; Leitinger, B.; Enghild, J.; Itoh, Y.
ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1)
Mol. Biol. Cell
26
659-673
2015
Homo sapiens (O14672)
Chaimowitz, N.; Kang, D.; Dean, L.; Conrad, D.
ADAM10 regulates transcription factor expression required for plasma cell function
PLoS ONE
7
e42694
2012
BRENDA: Mus musculus (O35598)
Textmining: Mus sp.
Raikwar, N.; Liu, K.; Thomas, C.
N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain
PLoS ONE
9
e112794
2014
Homo sapiens (O14672)
Loreto, C.; Chiarenza, G.P.; Musumeci, G.; Castrogiovanni, P.; Imbesi, R.; Ruggeri, A.; Almeida, L.E.; Leonardi, R.
ADAM10 localization in temporomandibular joint disk with internal derangement an ex vivo immunohistochemical study
Acta Histochem.
118
293-298
2016
BRENDA: Homo sapiens
Textmining: Oryctolagus cuniculus
Tan, Y.; Fu, R.; Liu, J.; Wu, Y.; Wang, B.; Jiang, N.; Nie, P.; Cao, H.; Yang, Z.; Fang, B.
ADAM10 is essential for cranial neural crest-derived maxillofacial bone development
Biochem. Biophys. Res. Commun.
475
308-314
2016
BRENDA: Mus musculus (O35598), Mus musculus
Textmining: Mus sp.
von Hoven, G.; Rivas, A.J.; Neukirch, C.; Klein, S.; Hamm, C.; Qin, Q.; Meyenburg, M.; Fueser, S.; Saftig, P.; Hellmann, N.; Postina, R.; Husmann, M.
Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus alpha-toxin action
Biochem. J.
473
1929-1940
2016
BRENDA: Homo sapiens (O14672), Homo sapiens
Textmining: Staphylococcus aureus, Mus sp.
Pabois, A.; Devalliere, J.; Quillard, T.; Coulon, F.; Gerard, N.; Laboisse, C.; Toquet, C.; Charreau, B.
The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells
Biochem. Pharmacol.
91
510-521
2015
BRENDA: Homo sapiens (O14672), Homo sapiens
Textmining: Areas
Dempsey, P.J.
Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis
Biochim. Biophys. Acta Mol. Cell Res.
1864
2228-2239
2017
Mus musculus
Vincent, B.
Regulation of the alpha-secretase ADAM10 at transcriptional, translational and post-translational levels
Brain Res. Bull.
126
154-169
2016
Homo sapiens (O14672)
You, B.; Shan, Y.; Shi, S.; Li, X.; You, Y.
Effects of ADAM10 upregulation on progression, migration, and prognosis of nasopharyngeal carcinoma
Cancer Sci.
106
1506-1514
2015
Homo sapiens (O14672), Homo sapiens
Altmeppen, H.C.; Prox, J.; Krasemann, S.; Puig, B.; Kruszewski, K.; Dohler, F.; Bernreuther, C.; Hoxha, A.; Linsenmeier, L.; Sikorska, B.; Liberski, P.P.; Bartsch, U.; Saftig, P.; Glatzel, M.
The sheddase ADAM10 is a potent modulator of prion disease
eLife
4
e04260
2015
BRENDA: Mus musculus (O35598)
Textmining: prion, Mus sp.
Kuhn, P.H.; Colombo, A.V.; Schusser, B.; Dreymueller, D.; Wetzel, S.; Schepers, U.; Herber, J.; Ludwig, A.; Kremmer, E.; Montag, D.; Mueller, U.; Schweizer, M.; Saftig, P.; Braese, S.; Lichtenthaler, S.F.
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
eLife
5
e12748
2016
BRENDA: Mus musculus (O35598), Mus musculus
Textmining: Mus sp.
Endres, K.; Deller, T.
Regulation of alpha-secretase ADAM10 in vitro and in vivo Genetic, epigenetic, and protein-based mechanisms
Front. Mol. Neurosci.
10
56
2017
Homo sapiens (O14672), Homo sapiens
Ruiz-Arroyo, V.M.; Garcia-Robles, I.; Ochoa-Campuzano, C.; Goig, G.A.; Zaitseva, E.; Baaken, G.; Martinez-Ramirez, A.C.; Rausell, C.; Real, M.D.
Validation of ADAM10 metalloprotease as a Bacillus thuringiensis Cry3Aa toxin functional receptor in Colorado potato beetle (Leptinotarsa decemlineata)
Insect Mol. Biol.
26
204-214
2017
BRENDA: Leptinotarsa decemlineata (A0A1L2JAW4), Leptinotarsa decemlineata
Textmining: Bacillus thuringiensis, Homo sapiens
Lundgren, J.L.; Ahmed, S.; Schedin-Weiss, S.; Gouras, G.K.; Winblad, B.; Tjernberg, L.O.; Frykman, S.
ADAM10 and BACE1 are localized to synaptic vesicles
J. Neurochem.
135
606-615
2015
BRENDA: Rattus norvegicus (O10743)
Textmining: Mus musculus, Rattus
Siney, E.J.; Holden, A.; Casselden, E.; Bulstrode, H.; Thomas, G.J.; Willaime-Morawek, S.
Metalloproteinases ADAM10 and ADAM17 mediate migration and differentiation in glioblastoma sphere-forming cells
Mol. Neurobiol.
54
3893-3905
2017
Homo sapiens (O14672), Homo sapiens
Madoux, F.; Dreymuller, D.; Pettiloud, J.P.; Santos, R.; Becker-Pauly, C.; Ludwig, A.; Fields, G.B.; Bannister, T.; Spicer, T.P.; Cudic, M.; Scampavia, L.D.; Minond, D.
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate
Sci. Rep.
6
11
2016
BRENDA: Homo sapiens (O14672)
Textmining: collection
Riethmueller, S.; Ehlers, J.C.; Lokau, J.; Duesterhoeft, S.; Knittler, K.; Dombrowsky, G.; Groetzinger, J.; Rabe, B.; Rose-John, S.; Garbers, C.
Cleavage site localization differentially controls interleukin-6 receptor proteolysis by ADAM10 and ADAM17
Sci. Rep.
6
25550
2016
Homo sapiens (O14672)
Folkesson, M.; Li, C.; Frebelius, S.; Swedenborg, J.; Wagsaeter, D.; Williams, K.J.; Eriksson, P.; Roy, J.; Liu, M.L.
Proteolytically active ADAM10 and ADAM17 carried on membrane microvesicles in human abdominal aortic aneurysms
Thromb. Haemost.
114
1165-1174
2015
BRENDA: Homo sapiens
Textmining: Electron, Nicotiana tabacum, Thrombus
O'Sullivan, SA; Gasparini, F; Mir, AK; Dev, KK
Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes.
J Neuroinflammation
13
189
2016
Homo sapiens
Toyama, S; Okada, N; Matsuda, A; Morita, H; Saito, H; Fujisawa, T; Nakae, S; Karasuyama, H; Matsumoto, K
Human eosinophils constitutively express a unique serine protease, PRSS33.
Allergol Int
2017
Homo sapiens
Tamkovich, SN; Yunusova, NV; Tugutova, E; Somov, AK; Proskura, KV; Kolomiets, LA; Stakheeva, MN; Grigoreva, AE; Laktionov, PP; Kondakova, IV
Protease Cargo in Circulating Exosomes of Breast Cancer and Ovarian Cancer Patients
Asian Pac J Cancer Prev
20
255-262
2019
Homo sapiens
Duru, EA; Fu, Y; Davies, MG
Protease-mediated human smooth muscle cell proliferation by urokinase requires epidermal growth factor receptor transactivation by triple membrane signaling.
J Surg Res
192
254-62
2014
Homo sapiens
Anderegg, U; Eichenberg, T; Parthaune, T; Haiduk, C; Saalbach, A; Milkova, L; Ludwig, A; Grosche, J; Averbeck, M; Gebhardt, C; Voelcker, V; Sleeman, JP; Simon, JC
ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells.
J Invest Dermatol
129
1471-82
2009
Homo sapiens
Franzč, E; Caruso, R; Stolfi, C; Sarra, M; Cupi, ML; Ascolani, M; Sedda, S; Antenucci, C; Ruffa, A; Caprioli, F; Macdonald, TT; Pallone, F; Monteleone, G
High Expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a Sheddase for TNF-? in the Mucosa of Patients with Inflammatory Bowel Diseases.
Inflamm Bowel Dis
19
501-11
2013
Homo sapiens
Clayton, KL; Douglas-Vail, MB; Rahman, AK; Medcalf, KE; Xie, IY; Chew, GM; Tandon, R; Lanteri, MC; Norris, PJ; Deeks, SG; Ndhlovu, LC; Ostrowski, MA
Soluble T Cell Immunoglobulin Mucin Domain 3 Is Shed from CD8+ T Cells by the Sheddase ADAM10, Is Increased in Plasma during Untreated HIV Infection, and Correlates with HIV Disease Progression.
J Virol
89
3723-36
2015
Human immunodeficiency virus 1, Homo sapiens, Mus musculus
Millichip, MI; Dallas, DJ; Wu, E; Dale, S; McKie, N
The metallo-disintegrin ADAM10 (MADM) from bovine kidney has type IV collagenase activity in vitro.
Biochem Biophys Res Commun
245
594-8
1998
Bos taurus, snake
Geng, L; Wang, W; Chen, Y; Cao, J; Lu, L; Chen, Q; He, R; Shen, W
Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model.
Exp Mol Pathol
89
72-81
2010
Metazoa, Rattus
Selistre de Araujo, HS; de Souza, DH; Ownby, CL
Analysis of a cDNA sequence encoding a novel member of the snake venom metalloproteinase, disintegrin-like, cysteine-rich (MDC) protein family from Agkistrodon contortrix laticinctus.
Biochim Biophys Acta
1342
109-15
1997
snake
Bernstein, HG; Steiner, J; Bogerts, B; Stricker, R; Reiser, G
Nardilysin, ADAM10, and Alzheimer's disease: of mice and men.
Neurobiol Aging
2013
Homo sapiens, Mus sp.
Marcinkiewicz, M; Seidah, NG
Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain.
J Neurochem
75
2133-43
2000
Homo sapiens, Mus musculus, Mus sp.
Kneidl, J; Löffler, B; Erat, MC; Kalinka, J; Peters, G; Roth, J; Barczyk, K
Soluble CD163 promotes recognition, phagocytosis and killing of Staphylococcus aureus via binding of specific fibronectin peptides.
Cell Microbiol
2012
Staphylococcus aureus
Guo, H; Xia, D; Liao, S; Niu, B; Tang, J; Hu, H; Qian, H; Cao, B
Vascular endothelial growth factor improves the cognitive decline of Alzheimer's disease via concurrently inducing the expression of ADAM10 and reducing the expression of ?-site APP cleaving enzyme 1 in Tg2576 mice.
Neurosci Res
2018
Mus sp.
Yoshimura, T; Tomita, T; Dixon, MF; Axon, AT; Robinson, PA; Crabtree, JE
ADAMs (a disintegrin and metalloproteinase) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa.
J Infect Dis
185
332-40
2002
Helicobacter, Helicobacter pylori, Homo sapiens
Arndt, M; Lendeckel, U; Rƶcken, C; Nepple, K; Wolke, C; Spiess, A; Huth, C; Ansorge, S; Klein, HU; Goette, A
Altered expression of ADAMs (A Disintegrin And Metalloproteinase) in fibrillating human atria.
Circulation
105
720-5
2002
Homo sapiens
Chen, RQ; Jin, Y; Wu, JB; Zhou, XD; Lu, QM; Wang, WY; Xiong, YL
A new protein structure of P-II class snake venom metalloproteinases: it comprises metalloproteinase and disintegrin domains.
Biochem Biophys Res Commun
310
182-7
2003
Protobothrops jerdonii
Karan, D; Lin, FC; Bryan, M; Ringel, J; Moniaux, N; Lin, MF; Batra, SK
Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas.
Int J Oncol
23
1365-71
2003
Homo sapiens
CissƩ, MA; Sunyach, C; Lefranc-Jullien, S; Postina, R; Vincent, B; Checler, F
The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity.
J Biol Chem
280
40624-31
2005
prion
Fedak, PW; Moravec, CS; McCarthy, PM; Altamentova, SM; Wong, AP; Skrtic, M; Verma, S; Weisel, RD; Li, RK
Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy.
Circulation
113
238-45
2006
Homo sapiens, insertion sequences
Chitadze, G; Lettau, M; Bhat, J; Wesch, D; Steinle, A; Fürst, D; Mytilineos, J; Kalthoff, H; Janssen, O; Oberg, HH; Kabelitz, D
Shedding of endogenous MHC class I-related chain molecules A and B (MICA and MICB) from different human tumor entities: Heterogeneous involvement of the a disintegrin and metalloproteases 10 and 17 (ADAM10 and ADAM17).
Int J Cancer
2013
Homo sapiens
Takahashi, H; Yuge, K; Matsubara, S; Ohkuchi, A; Kuwata, T; Usui, R; Suzuki, M; Takizawa, T
Differential expression of ADAM (a disintegrin and metalloproteinase) genes between human first trimester villous and extravillous trophoblast cells.
J Nippon Med Sch
81
122-9
2014
Homo sapiens
Franke, M; Schröder, J; Monhasery, N; Ackfeld, T; Hummel, TM; Rabe, B; Garbers, C; Becker-Pauly, C; Floss, DM; Scheller, J
Human and murine Interleukin 23 receptors are novel substrates for a disintegrin and metalloproteases ADAM10 and ADAM17.
J Biol Chem
2016
Homo sapiens, Mus musculus
Snyder, KM; McAloney, CA; Montel, JS; Modiano, JF; Walcheck, B
Ectodomain shedding by ADAM17 (a disintegrin and metalloproteinase 17) in canine neutrophils.
Vet Immunol Immunopathol
231
110162
2021
Canis lupus familiaris
Jarosz-Griffiths, HH; Corbett, NJ; Rowland, HA; Fisher, K; Jones, AC; Baron, J; Howell, GJ; Cowley, SA; Chintawar, S; Cader, MZ; Kellett, KAB; Hooper, NM
Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-? oligomers.
J Biol Chem
294
7085-7097
2019
prion, Homo sapiens
Möller, N; Ziesemer, S; Hildebrandt, P; Assenheimer, N; Völker, U; Hildebrandt, JP
S. aureus alpha-toxin monomer binding and heptamer formation in host cell membranes - Do they determine sensitivity of airway epithelial cells toward the toxin?
PLoS One
15
e0233854
2020
Homo sapiens
McKie, N; Edwards, T; Dallas, DJ; Houghton, A; Stringer, B; Graham, R; Russell, G; Croucher, PI
Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes.
Biochem Biophys Res Commun
230
335-9
1997
Bos taurus, Homo sapiens
Ochoa-Campuzano, C; Real, MD; MartĆnez-RamĆrez, AC; Bravo, A; Rausell, C
An ADAM metalloprotease is a Cry3Aa Bacillus thuringiensis toxin receptor.
Biochem Biophys Res Commun
362
437-42
2007
Bacillus thuringiensis, Leptinotarsa decemlineata
Xu, G; Wei, S; White, JM; DeSimone, DW
Identification and characterization of ADAM41, a novel ADAM metalloproteinase in Xenopus.
Int J Dev Biol
56
333-9
2012
Xenopus, Xenopus tropicalis
Habets, RA; Groot, AJ; Yahyanejad, S; Tiyanont, K; Blacklow, SC; Vooijs, M
Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17.
J Biol Chem
290
14705-16
2015
Mus musculus
Wang, L; Liu, Z; Shi, H; Liu, J
Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans.
PLoS Genet
13
e1006568
2017
Caenorhabditis elegans
Chen, W; Chen, C; Zhang, HX; Cao, J; Sang, W; Wu, QY; Zhao, K; Zang, Y; Zeng, LY; Xu, KL
[Cloning of Mouse adam10 Gene Promoter and Construction and Identification of Dual Luciferase Reporter System].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
20
740-3
2012
Mus musculus, plasmids
Schirrmeister, W; Gnad, T; Wex, T; Higashiyama, S; Wolke, C; Naumann, M; Lendeckel, U
Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection.
Exp Cell Res
2009
Helicobacter pylori, Homo sapiens, bacterium
Yang, Y; Wang, Y; Zeng, X; Ma, XJ; Zhao, Y; Qiao, J; Cao, B; Li, YX; Ji, L; Wang, YL
Self-Control of HGF Regulation on Human Trophoblast Cell Invasion via Enhancing c-Met Receptor Shedding by ADAM10 and ADAM17.
J Clin Endocrinol Metab
97
E1390-401
2012
Homo sapiens
Peng, Y; Lee, DY; Jiang, L; Ma, Z; Schachter, SC; Lemere, CA
Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
Neuroscience
150
386-95
2007
Homo sapiens
Ai, S; Lin, YY; Zheng, J; Qiu, CX; Liu, YJ; Lin, X
Effects of Shenkangling intervention on the MAPK pathway in rats with doxorubicin-induced nephropathy.
Genet Mol Res
15
2016
Rattus, Homo sapiens
Schmitt, U; Hiemke, C; Fahrenholz, F; Schroeder, A
Over-expression of two different forms of the alpha-secretase ADAM10 affects learning and memory in mice.
Behav Brain Res
175
278-84
2006
Mus sp., animal, Bos taurus, Mus musculus
Schuck, F; Schmitt, U; Reinhardt, S; Freese, C; Lee, IS; Thines, E; Efferth, T; Endres, K
Extract of Caragana sinica as a potential therapeutic option for increasing alpha-secretase gene expression.
Phytomedicine
22
1027-36
2015
Homo sapiens, Mus sp., Caenorhabditis sinica, Caragana sinica
G, V; S, K; Sureshkumar, ; G, S; S, S; Preethikrishnan, ; S, D; A, S; D, B; Riya, ; P, V
Therapeutic impact of rHuEPO on abnormal platelet APP, BACE 1, presenilin 1, ADAM 10 and A? expressions in chronic kidney disease patients with cognitive dysfunction like Alzheimer's disease: A pilot study.
Biomed Pharmacother
104
211-222
2018
Homo sapiens
Bram, JMF; Talib, LL; Joaquim, HPG; Sarno, TA; Gattaz, WF; Forlenza, OV
Protein levels of ADAM10, BACE1, and PSEN1 in platelets and leukocytes of Alzheimer's disease patients.
Eur Arch Psychiatry Clin Neurosci
2018
Homo sapiens
Lundgren, JL; Vandermeulen, L; Sandebring-Matton, A; Ahmed, S; Winblad, B; Di Luca, M; Tjernberg, LO; Marcello, E; Frykman, S
Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain.
BMC Neurosci
21
6
2020
Homo sapiens, Rattus, Mus musculus
Kim, J; Kim, H; Lee, SJ; Choi, YM; Lee, SJ; Lee, JY
Abundance of ADAM-8, -9, -10, -12, -15 and -17 and ADAMTS-1 in mouse uterus during the oestrous cycle.
Reprod Fertil Dev
17
543-55
2005
Oestrus, Mus musculus
Kieseier, BC; Pischel, H; Neuen-Jacob, E; Tourtellotte, WW; Hartung, HP
ADAM-10 and ADAM-17 in the inflamed human CNS.
Glia
42
398-405
2003
Homo sapiens
Matthews, V; Schuster, B; SchĆ¼tze, S; Bussmeyer, I; Ludwig, A; Hundhausen, C; Sadowski, T; Saftig, P; Hartmann, D; Kallen, KJ; Rose-John, S
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).
J Biol Chem
278
38829-39
2003
Homo sapiens
Lizama, C; Rojas-Benķtez, D; Antonelli, M; Ludwig, A; Bustamante-Marķn, X; Brouwer-Visser, J; Moreno, RD
TACE/ADAM17 is involved in germ cell apoptosis during rat spermatogenesis.
Reproduction
140
305-17
2010
Rattus
Pahl, R; Brunke, G; Steubesand, N; Schubert, S; Böttner, M; Wedel, T; Jürgensen, C; Hampe, J; Schäfer, H; Zeissig, S; Schreiber, S; Rosenstiel, P; Reiss, K; Arlt, A
IL-1{beta} and ADAM17 are central regulators of {beta}-defensin expression in Candida esophagitis.
Am J Physiol Gastrointest Liver Physiol
300
G547-53
2011
Candida
Lizama, C; Rojas-Benķtez, D; Antonelli, M; Ludwig, A; Moreno, RD
Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis.
J Cell Physiol
2011
Rattus
Hurst, LA; Bunning, RA; Sharrack, B; Woodroofe, MN
siRNA knockdown of ADAM-10, but not ADAM-17, significantly reduces fractalkine shedding following pro-inflammatory cytokine treatment in a human adult brain endothelial cell line.
Neurosci Lett
521
52-6
2012
Homo sapiens
Ebsen, H; Schröder, A; Kabelitz, D; Janssen, O
Differential surface expression of ADAM10 and ADAM17 on human T lymphocytes and tumor cells.
PLoS One
8
e76853
2013
Homo sapiens, Mus sp.
Del Turco, D; Schlaudraff, J; Bonin, M; Deller, T
Upregulation of APP, ADAM10 and ADAM17 in the denervated mouse dentate gyrus.
PLoS One
9
e84962
2014
Areas, Mus musculus
Li, Q; Xie, J; He, L; Wang, Y; Duan, Z; Yang, H; Wang, Q
Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis.
Gene
2015
Eriocheir sinensis
Speck, N; Brandsch, C; Schmidt, N; Yazdekhasti, N; Hirche, F; Lucius, R; Rimbach, G; Stangl, GI; Reiss, K
The Antiatherogenic Effect of Fish Oil in Male Mice Is Associated with a Diminished Release of Endothelial ADAM17 and ADAM10 Substrates.
J Nutr
145
1218-26
2015
Chondrichthyes, Mus sp.
Yan, I; Schwarz, J; Lücke, K; Schumacher, N; Schumacher, V; Schmidt, S; Rabe, B; Saftig, P; Donners, M; Rose-John, S; Mittrücker, HW; Chalaris, A
ADAM17 controls IL-6 signaling by cleavage of the murine IL-6R? from the cell surface of leukocytes during inflammatory responses.
J Leukoc Biol
2015
Mus musculus, Mus sp.
Walkiewicz, K; Nowakowska-Zajdel, E; Strzelczyk, J; Dzi?gielewska-G?siak, S; Muc-Wierzgo?, M
Serum levels of ADAM10, ADAM12, ADAM17 AND ADAM28 in colorectal cancer patients.
J Biol Regul Homeost Agents
31
929-934
0
Homo sapiens
Xie, Y; Ma, A; Wang, B; Peng, R; Jing, Y; Wang, D; Finnell, RH; Qiao, B; Wang, Y; Wang, H; Zheng, Y
Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling.
Clin Sci (Lond)
133
225-238
2019
Homo sapiens
Elfiky, AM; Mahmoud, AA; Elreedy, HA; Ibrahim, KS; Ghazy, MA
Quercetin stimulates the non-amyloidogenic pathway via activation of ADAM10 and ADAM17 gene expression in aluminum chloride-induced Alzheimer's disease rat model.
Life Sci
119964
2021
Rattus, Hippocampus
Fambrough, D; Pan, D; Rubin, GM; Goodman, CS
The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila.
Proc Natl Acad Sci U S A
93
13233-8
1996
Drosophila
Lunn, CA; Fan, X; Dalie, B; Miller, K; Zavodny, PJ; Narula, SK; Lundell, D
Purification of ADAM 10 from bovine spleen as a TNFalpha convertase.
FEBS Lett
400
333-5
1997
Bos taurus
Pan, D; Rubin, GM
Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis.
Cell
90
271-80
1997
Drosophila
Yamazaki, K; Mizui, Y; Tanaka, I
Radiation hybrid mapping of human ADAM10 gene to chromosome 15.
Genomics
45
457-9
1997
Homo sapiens
Wen, C; Metzstein, MM; Greenwald, I
SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling.
Development
124
4759-67
1997
Caenorhabditis elegans, Drosophila
Sotillos, S; Roch, F; Campuzano, S
The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs.
Development
124
4769-79
1997
Drosophila
Chubinskaya, S; Cs-Szabo, G; Kuettner, KE
ADAM-10 message is expressed in human articular cartilage.
J Histochem Cytochem
46
723-9
1998
Homo sapiens, Areas
Yavari, R; Adida, C; Bray-Ward, P; Brines, M; Xu, T
Human metalloprotease-disintegrin Kuzbanian regulates sympathoadrenal cell fate in development and neoplasia.
Hum Mol Genet
7
1161-7
1998
Homo sapiens, Drosophila
Chubinskaya, S; Mikhail, R; Deutsch, A; Tindal, MH
ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage.
J Histochem Cytochem
49
1165-76
2001
Areas, Bos taurus, Homo sapiens
Klein, T
kuzbanian is required cell autonomously during Notch signalling in the Drosophila wing.
Dev Genes Evol
212
251-5
2002
Drosophila
Ortiz, RM; KƤrkkƤinen, I; Huovila, AP; Honkaniemi, J
ADAM9, ADAM10, and ADAM15 mRNA levels in the rat brain after kainic acid-induced status epilepticus.
Brain Res Mol Brain Res
137
272-5
2005
Rattus, Hippocampus
Prinzen, C; MĆ¼ller, U; Endres, K; Fahrenholz, F; Postina, R
Genomic structure and functional characterization of the human ADAM10 promoter.
FASEB J
19
1522-4
2005
Homo sapiens, Mus musculus
Marshall, AJ; Rattray, M; Vaughan, PF
Chronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative alpha-secretases, ADAM10 and TACE, without altering their mRNA levels.
Brain Res
1099
18-24
2006
Homo sapiens, Metazoa
Eichenauer, DA; Simhadri, VL; von Strandmann, EP; Ludwig, A; Matthews, V; Reiners, KS; von Tresckow, B; Saftig, P; Rose-John, S; Engert, A; Hansen, HP
ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro.
Cancer Res
67
332-8
2007
Homo sapiens, Mus musculus
Arima, T; Enokida, H; Kubo, H; Kagara, I; Matsuda, R; Toki, K; Nishimura, H; Chiyomaru, T; Tatarano, S; Idesako, T; Nishiyama, K; Nakagawa, M
Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer.
Cancer Sci
98
1720-6
2007
Homo sapiens
Schroeder, A; Fahrenholz, F; Schmitt, U
Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease.
J Alzheimers Dis
16
309-14
2009
Homo sapiens, Mus musculus, Mus sp.
Udolph, G; Rath, P; Tio, M; Toh, J; Fang, W; Pandey, R; Technau, GM; Chia, W
On the roles of Notch, Delta, kuzbanian, and inscuteable during the development of Drosophila embryonic neuroblast lineages.
Dev Biol
2009
Drosophila
Gutwein, P; Schramme, A; Abdel-Bakky, MS; Doberstein, K; Hauser, IA; Ludwig, A; Altevogt, P; Gauer, S; Hillmann, A; Weide, T; Jespersen, C; Eberhardt, W; Pfeilschifter, J
ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases.
J Biomed Sci
17
3
2010
Homo sapiens
Wilke, GA; Bubeck Wardenburg, J
Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury.
Proc Natl Acad Sci U S A
107
13473-8
2010
Staphylococcus aureus
Wang, YY; Ye, ZY; Li, L; Zhao, ZS; Shao, QS; Tao, HQ
ADAM 10 is associated with gastric cancer progression and prognosis of patients.
J Surg Oncol
2010
Homo sapiens
Wang, YY; Ye, ZY; Li, L; Zhao, ZS; Shao, QS; Tao, HQ
ADAM 10 is associated with gastric cancer progression and prognosis of patients.
J Surg Oncol
103
116-23
2011
Homo sapiens
Mathews, JA; Ford, J; Norton, S; Kang, D; Dellinger, A; Gibb, DR; Ford, AQ; Massay, H; Kepley, CL; Scherle, P; Keegan, AD; Conrad, DH
A potential new target for asthma therapy: A Disintegrin and Metalloprotease 10 (ADAM10) involvement in murine experimental asthma.
Allergy
66
1193-1200
2011
Mus musculus, Mus sp., Metazoa
Friedrich, BM; Murray, JL; Li, G; Sheng, J; Hodge, TW; Rubin, DH; O'Brien, WA; Ferguson, MR
A functional role for ADAM10 in human immunodeficiency virus type-1 replication.
Retrovirology
8
32
2011
Human Immunodeficiency Virus, Reovirus sp., Human immunodeficiency virus 1, Viruses
Altmeppen, HC; Prox, J; Puig, B; Kluth, MA; Bernreuther, C; Thurm, D; Jorissen, E; Petrowitz, B; Bartsch, U; De Strooper, B; Saftig, P; Glatzel, M
Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo.
Mol Neurodegener
6
36
2011
prion
Liu, WH; Chang, LS
Fas/FasL-dependent and -independent activation of caspase-8 in doxorubicin-treated human breast cancer MCF-7 cells: ADAM10 down-regulation activates Fas/FasL signaling pathway.
Int J Biochem Cell Biol
2011
Homo sapiens
Inoshima, I; Inoshima, N; Wilke, GA; Powers, ME; Frank, KM; Wang, Y; Bubeck Wardenburg, J
A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice.
Nat Med
17
1310-4
2011
Staphylococcus aureus, Mus sp., Homo sapiens
Inoshima, N; Wang, Y; Wardenburg, JB
Genetic Requirement for ADAM10 in Severe Staphylococcus aureus Skin Infection.
J Invest Dermatol
2012
Staphylococcus aureus
Tharmarajah, G; Faas, L; Reiss, K; Saftig, P; Young, A; Van Raamsdonk, CD
Adam10 haploinsufficiency causes freckle-like macules in Hairless mice.
Pigment Cell Melanoma Res
25
555-565
2012
Homo sapiens, Mus musculus, Mus sp.
Guo, J; He, L; Yuan, P; Wang, P; Lu, Y; Tong, F; Wang, Y; Yin, Y; Tian, J; Sun, J
ADAM10 overexpression in human non-small cell lung cancer correlates with cell migration and invasion through the activation of the Notch1 signaling pathway.
Oncol Rep
28
1709-18
2012
Homo sapiens
Kitaoka, K; Shimizu, N; Ono, K; Chikahisa, S; Nakagomi, M; Shudo, K; Ishimura, K; Séi, H; Yoshizaki, K
The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice.
Neuropharmacology
72
58-65
2013
Mus sp., Hippocampus, Mus musculus
Yuan, S; Lei, S; Wu, S
ADAM10 is overexpressed in human hepatocellular carcinoma and contributes to the proliferation, invasion and migration of HepG2 cells.
Oncol Rep
30
1715-22
2013
Homo sapiens
Yue, Y; Shao, Y; Luo, Q; Shi, L; Wang, Z
Downregulation of ADAM10 Expression Inhibits Metastasis and Invasiveness of Human Hepatocellular Carcinoma HepG2 Cells.
Biomed Res Int
2013
434561
2013
Homo sapiens
Yang, K; Lu, L; Liu, Y; Zhang, Q; Pu, LJ; Wang, LJ; Zhu, ZB; Wang, YN; Meng, H; Zhang, XJ; Du, R; Chen, QJ; Shen, WF
Increase of ADAM10 level in coronary artery in-stent restenosis segments in diabetic minipigs: high ADAM10 expression promoting growth and migration in human vascular smooth muscle cells via Notch 1 and 3.
PLoS One
8
e83853
2013
Homo sapiens
Dzieciuchowicz, L; Espinosa, G; Pįramo, JA
Increased Levels of Metalloproteinase 10 and Hemostatic Markers in Patients With Noncomplicated Primary Varicose Veins.
Clin Appl Thromb Hemost
2014
Homo sapiens
Kai, Y; Peng, W; Ling, W; Jiebing, H; Zhuan, B
Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells.
Biochem Biophys Res Commun
2014
Homo sapiens
Ji, YJ; Hwang, YS; Mood, K; Cho, HJ; Lee, HS; Winterbottom, E; Cousin, H; Daar, IO
EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1.
Nat Commun
5
3516
2014
Xenopus
Endsley, MA; Somasunderam, AD; Li, G; Oezguen, N; Thiviyanathan, V; Murray, JL; Rubin, DH; Hodge, TW; O?brien, WA; Lewis, B; Ferguson, MR
Nuclear trafficking of the HIV-1 pre-integration complex depends on the ADAM10 intracellular domain.
Virology
454-455C
60-66
2014
Human immunodeficiency virus 1, Homo sapiens
Ohtake, N; Saito, M; Eto, M; Seki, K
Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex.
Regul Pept
190-191
1-11
2014
Mus musculus, insertion sequences, Mus sp., Rodentia
Chen, C; Lv, Y; Zhang, BY; Zhang, J; Shi, Q; Wang, J; Tian, C; Gao, C; Xiao, K; Ren, K; Zhou, W; Dong, XP
Apparent Reduction of ADAM10 in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents.
Mol Neurobiol
2014
Cricetinae, Homo sapiens, Mus sp., prion, Rodentia
,
Retracted: Downregulation of ADAM10 expression inhibits metastasis and invasiveness of human hepatocellular carcinoma HepG2 cells.
Biomed Res Int
2014
308263
2014
Homo sapiens
Musumeci, G; Coleman, R; Imbesi, R; Magro, G; Parenti, R; Szychlinska, MA; Scuderi, R; Ciną, CS; Castorina, S; Castrogiovanni, P
ADAM-10 could mediate cleavage of N-cadherin promoting apoptosis in human atherosclerotic lesions leading to vulnerable plaque: A morphological and immunohistochemical study.
Acta Histochem
116
1148-58
2014
Homo sapiens, Thrombus
Ergün, S; Ulasli, M; Igci, YZ; Igci, M; K?rkbes, S; Borazan, E; Balik, A; Yumruta?, Ö; Camci, C; Cakmak, EA; Arslan, A; Oztuzcu, S
The association of the expression of miR-122-5p and its target ADAM10 with human breast cancer.
Mol Biol Rep
42
497-505
2015
Homo sapiens
Shao, Y; Sha, XY; Bai, YX; Quan, F; Wu, SL
Effect of A disintegrin and metalloproteinase 10 gene silencing on the proliferation, invasion and migration of the human tongue squamous cell carcinoma cell line TCA8113.
Mol Med Rep
11
212-8
2015
Homo sapiens
Zhuang, J; Wei, Q; Lin, Z; Zhou, C
Effects of ADAM10 deletion on Notch-1 signaling pathway and neuronal maintenance in adult mouse brain.
Gene
555
150-8
2015
Mus musculus, Mus sp., Hippocampus
Cui, L; Gao, Y; Xie, Y; Wang, Y; Cai, Y; Shao, X; Ma, X; Li, Y; Ma, G; Liu, G; Cheng, W; Liu, Y; Liu, T; Pan, Q; Tao, H; Liu, Z; Zhao, B; Shao, Y; Li, K
An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis.
Crit Care
19
73
2015
Homo sapiens
Cooley, LF; Martin, RK; Zellner, HB; Irani, AM; Uram-Tuculescu, C; El Shikh, ME; Conrad, DH
Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice.
PLoS One
10
e0124331
2015
Homo sapiens, Mus sp., Mus musculus
Qu, M; Qiu, BO; Xiong, W; Chen, D; Wu, A
Expression of a-disintegrin and metalloproteinase 10 correlates with grade of malignancy in human glioma.
Oncol Lett
9
2157-2162
2015
Homo sapiens
Manzine, PR; Marcello, E; Borroni, B; Kamphuis, W; Hol, E; Padovani, A; Nascimento, CC; de Godoy Bueno, P; Assis Carvalho Vale, F; Iost Pavarini, SC; Di Luca, M; Cominetti, MR
ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects.
Biomarkers
20
196-201
2015
Homo sapiens
Donizy, P; Zietek, M; Leskiewicz, M; Halon, A; Matkowski, R
High percentage of ADAM-10 positive melanoma cells correlates with paucity of tumor-infiltrating lymphocytes but does not predict prognosis in cutaneous melanoma patients.
Anal Cell Pathol (Amst)
2015
975436
2015
Homo sapiens
Bianco, OA; Manzine, PR; Nascimento, CM; Vale, FA; Pavarini, SC; Cominetti, MR
Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's disease.
Int Psychogeriatr
1-6
2015
Homo sapiens
Sarlak, G; Htoo, HH; Hernandez, JF; Iizasa, H; Checler, F; Konietzko, U; Song, W; Vincent, B
Sox2 functionally interacts with ?APP, the ?APP intracellular domain and ADAM10 at a transcriptional level in human cells.
Neuroscience
312
153-64
2016
Homo sapiens, Mus musculus
Müller, M; Wetzel, S; Köhn-Gaone, J; Chalupsky, K; Lüllmann-Rauch, R; Barikbin, R; Bergmann, J; Wöhner, B; Zbodakova, O; Leuschner, I; Martin, G; Tiegs, G; Rose-John, S; Sedlacek, R; Tirnitz-Parker, JE; Saftig, P; Schmidt-Arras, D
A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis.
Oncotarget
2016
Mus musculus, Mus sp.
Ma, B; Zhang, HY; Bai, X; Wang, F; Ren, XH; Zhang, L; Zhang, MZ
ADAM10 mediates the cell invasion and metastasis of human esophageal squamous cell carcinoma via regulation of E-cadherin activity.
Oncol Rep
35
2785-94
2016
Homo sapiens
Kwon, J; Jeong, SM; Choi, I; Kim, NH
ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development.
PLoS One
11
e0152921
2016
Sus scrofa
Ezekwe, EA; Weng, C; Duncan, JA
ADAM10 Cell Surface Expression but Not Activity Is Critical for Staphylococcus aureus ?-Hemolysin-Mediated Activation of the NLRP3 Inflammasome in Human Monocytes.
Toxins (Basel)
8
2016
Staphylococcus aureus, Homo sapiens, bacterium
Guo, ZB; Su, YY; Wang, YH; Wang, W; Guo, DZ
The expression pattern of Adam10 in the central nervous system of adult mice: Detection by in situ hybridization combined with immunohistochemistry staining.
Mol Med Rep
14
2038-44
2016
Mus sp., Mus musculus, Hippocampus
Įlvarez-Fernįndez, SM; Barbariga, M; Cannizzaro, L; Cannistraci, CV; Hurley, L; Zanardi, A; Conti, A; Sanvito, F; Innocenzi, A; Pecorelli, N; Braga, M; Alessio, M
Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients.
Oncotarget
2016
Homo sapiens
Zepeda-Nuńo, JS; Guerrero-Velįzquez, C; Del Toro-Arreola, S; Vega-Magańa, N; Įngeles-Sįnchez, J; Haramati, J; Pereira-Suįrez, AL; Bueno-Topete, MR
Expression of ADAM10, Fas, FasL and Soluble FasL in Patients with Oral Squamous Cell Carcinoma (OSCC) and their Association with Clinical-Pathological Parameters.
Pathol Oncol Res
2016
Homo sapiens
Le Manh, H; Guio, L; Merenciano, M; Rovira, Q; Barrón, MG; Gonzįlez, J
Natural and laboratory mutations in kuzbanian are associated with zinc stress phenotypes in Drosophila melanogaster.
Sci Rep
7
42663
2017
Drosophila melanogaster
Ostalecki, C; Lee, JH; Dindorf, J; Collenburg, L; Schierer, S; Simon, B; Schliep, S; Kremmer, E; Schuler, G; Baur, AS
Multiepitope tissue analysis reveals SPPL3-mediated ADAM10 activation as a key step in the transformation of melanocytes.
Sci Signal
10
2017
Transformation
Meng, T; Cao, Q; Lei, P; Bush, AI; Xiang, Q; Su, Z; He, X; Rogers, JT; Chiu, IM; Zhang, Q; Huang, Y
Tat-haFGF14-154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1?/XBP1 Pathway.
Mol Ther Nucleic Acids
7
439-452
2017
Mus sp.
Damle, SR; Martin, RK; Cockburn, CL; Lownik, JC; Carlyon, JA; Smith, AD; Conrad, DH
ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production.
Allergy
2017
Mus musculus, Alternaria, Mus sp.
Reboud, E; Bouillot, S; Patot, S; Béganton, B; Attrée, I; Huber, P
Pseudomonas aeruginosa ExlA and Serratia marcescens ShlA trigger cadherin cleavage by promoting calcium influx and ADAM10 activation.
PLoS Pathog
13
e1006579
2017
Pseudomonas aeruginosa, Serratia marcescens, Bacteria
Qiao, J; Luo, Q; Liu, N; Wei, G; Wu, X; Lu, J; Tang, K; Wu, Y; Zi, J; Li, X; Liu, Y; Ju, W; Qi, K; Yan, Z; Li, Z; Zeng, L; Xu, K
Increased ADAM10 expression in patients with immune thrombocytopenia.
Int Immunopharmacol
55
63-68
2018
Homo sapiens
Lécuyer, H; Virion, Z; Barnier, JP; Matczak, S; Bourdoulous, S; Bianchini, E; Saller, F; Borgel, D; Nassif, X; Coureuil, M
An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans.
PLoS Pathog
14
e1006981
2018
Purpura, Neisseria meningitidis
Wan, N; Xu, Z; Chi, Q; Hu, X; Pan, T; Liu, T; Li, S
microRNA-33-3p involved in selenium deficiency-induced apoptosis via targeting ADAM10 in the chicken kidney.
J Cell Physiol
2019
Gallus gallus
Lownik, JC; Wimberly, JL; Conrad, DH; Martin, RK
B Cell ADAM10 Controls Murine Lupus Progression through Regulation of the ICOS:ICOS Ligand Axis.
J Immunol
202
664-674
2019
Mus musculus, Mus sp.
Fic, W; Faria, C; St Johnston, D
IMP regulates Kuzbanian to control the timing of Notch signalling in Drosophila follicle cells.
Development
146
2019
Drosophila
Zhu, X; Yao, Y; Liu, Y; Zhou, R; Zhang, W; Hu, Q; Liu, H; Al Hamda, MH; Zhang, A
Regulation of ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.
Front Cell Neurosci
13
180
2019
Mus sp., Hippocampus
Meng, H; Huang, Q; Zhang, X; Huang, J; Shen, R; Zhang, B
MiR-449a regulates the cell migration and invasion of human non-small cell lung carcinoma by targeting ADAM10.
Onco Targets Ther
12
3829-3838
2019
Homo sapiens
Fujita, K; Chakarov, S; Kobayashi, T; Sakamoto, K; Voisin, B; Duan, K; Nakagawa, T; Horiuchi, K; Amagai, M; Ginhoux, F; Nagao, K
Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen.
Proc Natl Acad Sci U S A
116
14714-14723
2019
Mus musculus, Mus sp.
Ivars, M; Espańa, A; Alzuguren, P; Pelacho, B; Lasarte, JJ; López-Zabalza, MJ
The involvement of ADAM10 in mucocutaneous pemphigus vulgaris acantholysis depends on the autoantibody profile in each patient.
Br J Dermatol
2019
Mus musculus, Pemphigus
Yao, Y; Sun, W; Sun, Q; Jing, B; Liu, S; Liu, X; Shen, G; Chen, R; Wang, H
Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-?B Signaling Pathway in ApoE-/- Mice.
Front Immunol
10
2205
2019
Mus sp.
Zhang, W; Lu, F; Xie, Y; Lin, Y; Zhao, T; Tao, S; Lai, Z; Wei, N; Yang, R; Shao, Y; He, J
miR-23b Negatively Regulates Sepsis-Induced Inflammatory Responses by Targeting ADAM10 in Human THP-1 Monocytes.
Mediators Inflamm
2019
5306541
2019
Homo sapiens
Mizuno, S; Yoda, M; Kimura, T; Shimoda, M; Akiyama, H; Chiba, K; Nakamura, M; Horiuchi, K
ADAM10 is indispensable for longitudinal bone growth in mice.
Bone
134
115273
2020
Mus sp.
Xie, Z; Shen, P; Qu, Y; Xu, J; Zheng, C; Gao, Y; Wang, B
MiR-20a inhibits the progression of human arthritis fibroblast-like synoviocytes and inflammatory factor expression by targeting ADAM10.
Environ Toxicol
35
867-878
2020
Homo sapiens
Lustgarten Guahmich, N; Farber, G; Shafiei, S; McNally, D; Redmond, D; Kallinos, E; Stuhlmann, H; Dufort, D; James, D; Blobel, CP
Endothelial deletion of ADAM10, a key regulator of Notch signaling, causes impaired decidualization and reduced fertility in female mice.
Angiogenesis
23
443-458
2020
Mus sp.
Xu, Y; Lai, Y; Cao, L; Li, Y; Chen, G; Chen, L; Weng, H; Chen, T; Wang, L; Ye, Y
Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-451a represses epithelial-mesenchymal transition of hepatocellular carcinoma cells by inhibiting ADAM10.
RNA Biol
1-16
2020
Homo sapiens
Appel, D; Hummel, R; Weidemeier, M; Endres, K; Gölz, C; Schäfer, MKE
Pharmacologic Inhibition of ADAM10 Attenuates Brain Tissue Loss, Axonal Injury and Pro-inflammatory Gene Expression Following Traumatic Brain Injury in Mice.
Front Cell Dev Biol
9
661462
2021
Mus sp.
Dang, NN; Li, XB; Zhang, M; Han, C; Fan, XY; Huang, SH
NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.
Front Cell Dev Biol
9
662763
2021
Homo sapiens
Renfeng, Q; Shuxiao, C; Peixian, G; Kun, L; Xuedong, F; Hai, Y; Xuejun, W; Gang, L
ADAM10 attenuates the development of abdominal aortic aneurysms in a mouse model.
Mol Med Rep
24
2021
Mus musculus, Sus scrofa
Okamori, S; Ishii, M; Asakura, T; Suzuki, S; Namkoong, H; Kagawa, S; Hegab, AE; Yagi, K; Kamata, H; Kusumoto, T; Ogawa, T; Takahashi, H; Yoda, M; Horiuchi, K; Hasegawa, N; Fukunaga, K
ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myeloid Cell Population.
Am J Physiol Lung Cell Mol Physiol
2021
Mus sp.
Sieuwerts, AM; Meijer-van Gelder, ME; Timmermans, M; Trapman, AM; Garcia, RR; Arnold, M; Goedheer, AJ; Portengen, H; Klijn, JG; Foekens, JA
How ADAM-9 and ADAM-11 differentially from estrogen receptor predict response to tamoxifen treatment in patients with recurrent breast cancer: a retrospective study.
Clin Cancer Res
11
7311-21
2005
Homo sapiens
Tajes, M; Gutierrez-Cuesta, J; OrtuƱo-Sahagun, D; Camins, A; PallĆ s, M
Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway.
J Pineal Res
47
228-37
2009
Mus musculus, animal
Velįsquez, SY; Opelz, G; Rojas, M; Süsal, C; Alvarez, CM
Association of CD30 transcripts with Th1 responses and proinflammatory cytokines in patients with end-stage renal disease.
Hum Immunol
2016
Homo sapiens
Wei, S; Xie, Z; Filenova, E; Brew, K
Drosophila TIMP is a potent inhibitor of MMPs and TACE: similarities in structure and function to TIMP-3.
Biochemistry
42
12200-7
2003
Drosophila, Homo sapiens
Lavens, SE; Rovira-Graells, N; Birch, M; Tuckwell, D
ADAMs are present in fungi: identification of two novel ADAM genes in Aspergillus fumigatus.
FEMS Microbiol Lett
248
23-30
2005
Fungi
Jarriault, S; Greenwald, I
Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE.
Dev Biol
287
1-10
2005
Caenorhabditis elegans, Drosophila
Barlic, J; Zhu, W; Murphy, PM
Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion.
J Immunol
182
7928-36
2009
Homo sapiens, Mus musculus
Wei, S; Whittaker, CA; Xu, G; Bridges, LC; Shah, A; White, JM; Desimone, DW
Conservation and divergence of ADAM family proteins in the Xenopus genome.
BMC Evol Biol
10
211
2010
Mammalia, Xenopus
Yang, M; Li, Y; Chilukuri, K; Brady, OA; Boulos, MI; Kappes, JC; Galileo, DS
L1 stimulation of human glioma cell motility correlates with FAK activation.
J Neurooncol
2011
Homo sapiens, Rattus
Chu, J; Lauretti, E; Craige, CP; Praticņ, D
Pharmacological Modulation of GSAP Reduces Amyloid-? Levels and Tau Phosphorylation in a Mouse Model of Alzheimer's Disease with Plaques and Tangles.
J Alzheimers Dis
2014
Mus sp.
Li, R; Yu, H; Yue, Y; Liu, S; Xing, R; Chen, X; Li, P
Combined proteomics and transcriptomics identifies sting-related toxins of jellyfish Cyanea nozakii.
J Proteomics
148
57-64
2016
Metazoa
Antonelli, A; Di Maggio, S; Rejman, J; Sanvito, F; Rossi, A; Catucci, A; Gorzanelli, A; Bragonzi, A; Bianchi, ME; Raucci, A
The shedding-derived soluble receptor for advanced glycation endproducts sustains inflammation during acute Pseudomonas aeruginosa lung infection.
Biochim Biophys Acta
1861
354-364
2017
Homo sapiens, Mus sp., Pseudomonas aeruginosa
Maitra, S; Sornjai, W; Smith, DR; Vincent, B
Phenanthroline impairs ?APP processing and expression, increases p53 protein levels and induces cell cycle arrest in human neuroblastoma cells.
Brain Res Bull
170
29-38
2021
Homo sapiens, Chelator
Seipel, D; Oliveira, BC; Resende, TL; Schuindt, SH; Pimentel, PM; Kanashiro, MM; Arnholdt, AC
Toxoplasma gondii infection positively modulates the macrophages migratory molecular complex by increasing matrix metalloproteinases, CD44 and alpha v beta 3 integrin.
Vet Parasitol
169
312-9
2010
Toxoplasma gondii, Mus musculus
Mori, T; Koyama, N; Yokoo, T; Segawa, T; Maeda, M; Sawmiller, D; Tan, J; Town, T
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
J Biol Chem
2020
Mus sp., Homo sapiens, Rodentia, Mus musculus
Lancellotti, S; Dragani, A; Ranalli, P; Petrucci, G; Basso, M; Tartaglione, R; Rocca, B; De Cristofaro, R
Qualitative and quantitative modifications of von Willebrand factor in patients with essential thrombocythemia and controlled platelet count.
J Thromb Haemost
13
1226-37
2015
Homo sapiens, Goose parvovirus
Altmeppen, HC; Prox, J; Puig, B; Dohler, F; Falker, C; Krasemann, S; Glatzel, M
Roles of endoproteolytic ?-cleavage and shedding of the prion protein in neurodegeneration.
FEBS J
2013
prion
Houri, N; Huang, KC; Nalbantoglu, J
The Coxsackievirus and Adenovirus Receptor (CAR) Undergoes Ectodomain Shedding and Regulated Intramembrane Proteolysis (RIP).
PLoS One
8
e73296
2013
coxsackievirus
Del Campo, M; Hoozemans, JJ; Dekkers, LL; Rozemuller, AJ; Korth, C; Müller-Schiffmann, A; Scheltens, P; Blankenstein, MA; Jimenez, CR; Veerhuis, R; Teunissen, CE
BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease.
Neurobiol Aging
35
1596-604
2014
Hippocampus
Glatzel, M; Linsenmeier, L; Dohler, F; Krasemann, S; Puig, B; Altmeppen, HC
Shedding light on prion disease.
Prion
9
244-56
2015
prion, Mus sp.
Linsenmeier, L; Mohammadi, B; Wetzel, S; Puig, B; Jackson, WS; Hartmann, A; Uchiyama, K; Sakaguchi, S; Endres, K; Tatzelt, J; Saftig, P; Glatzel, M; Altmeppen, HC
Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein.
Mol Neurodegener
13
18
2018
prion
Ri, A; Hagiyama, M; Inoue, T; Yoneshige, A; Kimura, R; Murakami, Y; Ito, A
Progression of Pulmonary Emphysema and Continued Increase in Ectodomain Shedding of Cell Adhesion Molecule 1 After Cessation of Cigarette Smoke Exposure in Mice.
Front Cell Dev Biol
6
52
2018
Mus sp.
de Oliveira, M; De Sibio, MT; Mathias, LS; Rodrigues, BM; Sakalem, ME; Nogueira, CR
Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture.
Mol Cell Endocrinol
515
110917
2020
Alphacoronavirus, Homo sapiens, Severe acute respiratory syndrome coronavirus 2
Nwogu, N; Ortiz, LE; Whitehouse, A; Kwun, HJ
Merkel Cell Polyomavirus Small Tumor Antigen Activates Matrix Metallopeptidase-9 Gene Expression for Cell Migration and Invasion.
J Virol
94
2020
Merkel cell polyomavirus, Homo sapiens, Transformation
Sriranganathan, S; Tutunea-Fatan, E; Abbasi, A; Gunaratnam, L
Mapping and functional characterization of murine kidney injury molecule-1 proteolytic cleavage site.
Mol Cell Biochem
476
1093-1108
2021
Mus musculus
Diaz-Lucena, D; Kruse, N; Thüne, K; Schmitz, M; Villar-Piqué, A; da Cunha, JEG; Hermann, P; López-Pérez, Ó; Andrés-Benito, P; Ladogana, A; Calero, M; Vidal, E; Riggert, J; Pineau, H; Sim, V; Zetterberg, H; Blennow, K; Del Rķo, JA; Marķn-Moreno, A; Espinosa, JC; Torres, JM; Sįnchez-Valle, R; Mollenhauer, B; Ferrer, I; Zerr, I; Llorens, F
TREM2 expression in the brain and biological fluids in prion diseases.
Acta Neuropathol
141
841-859
2021
prion, Homo sapiens
Guardiola-Serrano, F; Rossin, A; Cahuzac, N; Lückerath, K; Melzer, I; Mailfert, S; Marguet, D; Zörnig, M; Hueber, AO
Palmitoylation of human FasL modulates its cell death-inducing function.
Cell Death Dis
1
e88
2010
Homo sapiens
Lu, J; Wang, X; Wang, W; Muniyappa, H; Hu, C; Mitra, S; Long, B; Das, K; Mehta, JL
LOX-1 abrogation reduces cardiac hypertrophy and collagen accumulation following chronic ischemia in the mouse.
Gene Ther
2011
Mus sp.
da Silva, AVA; Figueiredo, FB; Menezes, RC; Mendes-Junior, AA; de Miranda, LHM; Cupolillo, E; Porrozzi, R; Morgado, FN
Morphophysiological changes in the splenic extracellular matrix of Leishmania infantum-naturally infected dogs is associated with alterations in lymphoid niches and the CD4+ T cell frequency in spleens.
PLoS Negl Trop Dis
12
e0006445
2018
Metazoa
Torres, LN; Salgado, CL; Dubick, MA; Cap, AP; Torres Filho, IP
Role of albumin on endothelial basement membrane and hemostasis in a rat model of hemorrhagic shock.
J Trauma Acute Care Surg
91
S65-S73
2021
Rattus
Li, WX; Deng, YY; Li, F; Liu, B; Liu, HY; Shi, JS; Gong, QH
Icariin, a major constituent of flavonoids from Epimedium brevicornum, protects against cognitive deficits induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats.
Pharmacol Biochem Behav
138
40-8
2015
Hippocampus, Rattus
Zeng, J; Li, T; Gong, M; Jiang, W; Yang, T; Chen, J; Liu, Y; Chen, L
Marginal Vitamin A Deficiency Exacerbates Memory Deficits Following A?1-42 Injection in Rats.
Curr Alzheimer Res
2016
Rattus
Rui, Y; Lv, M; Chang, J; Xu, J; Qin, L; Wan, Z
Chia Seed Does Not Improve Cognitive Impairment in SAMP8 Mice Fed with High Fat Diet.
Nutrients
10
2018
Hippocampus
Yang, C; Bao, X; Zhang, L; Li, Y; Li, L; Zhang, L
Cornel iridoid glycoside ameliorates cognitive deficits in APP/PS1/tau triple transgenic mice by attenuating amyloid-beta, tau hyperphosphorylation and neurotrophic dysfunction.
Ann Transl Med
8
328
2020
Mus sp.
Taylor, DR; Parkin, ET; Cocklin, SL; Ault, JR; Ashcroft, AE; Turner, AJ; Hooper, NM
Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein.
J Biol Chem
284
22590-600
2009
prion
Rasila, T; Saavalainen, O; Attalla, H; Lankila, P; Haglund, C; Hölttä, E; Andersson, LC
Astroprincin (FAM171A1, C10orf38): A Regulator of Human Cell Shape and Invasive Growth.
Am J Pathol
189
177-189
2019
Saccharomyces cerevisiae
Li, M; Xue, W; Li, X; Song, Y; Liu, X; Qin, L
Axl is related to inflammation in hemodialysis patients.
Mol Immunol
133
146-153
2021
Homo sapiens
He, T; Sun, R; Santhanam, AV; d'Uscio, LV; Lu, T; Katusic, ZS
Impairment of amyloid precursor protein alpha-processing in cerebral microvessels of type 1 diabetic mice.
J Cereb Blood Flow Metab
271678X17746981
2017
Mus sp.
Didangelos, A
COVID-19 Hyperinflammation: What about Neutrophils?
mSphere
5
2020
Severe acute respiratory syndrome coronavirus 2
Lendeckel, U; Kohl, J; Arndt, M; Carl-McGrath, S; Donat, H; Rƶcken, C
Increased expression of ADAM family members in human breast cancer and breast cancer cell lines.
J Cancer Res Clin Oncol
131
41-8
2005
Homo sapiens
Auerbach, ID; Vinters, HV
Effects of anoxia and hypoxia on amyloid precursor protein processing in cerebral microvascular smooth muscle cells.
J Neuropathol Exp Neurol
65
610-20
2006
Anoxia
Lin, J; Luo, J; Redies, C
Differential expression of five members of the ADAM family in the developing chicken brain.
Neuroscience
157
360-75
2008
Gallus gallus
Coyne, MJ; Cousin, H; Loftus, JP; Johnson, PJ; Belknap, JK; Gradil, CM; Black, SJ; Alfandari, D
Cloning and expression of ADAM-related metalloproteases in equine laminitis.
Vet Immunol Immunopathol
129
231-41
2009
Equidae, Metazoa
Lin, J; Yan, X; Markus, A; Redies, C; Rolfs, A; Luo, J
Expression of seven members of the ADAM family in developing chicken spinal cord.
Dev Dyn
239
1246-54
2010
Gallus gallus
Yan, X; Lin, J; Wang, H; Markus, A; Wree, A; Rolfs, A; Luo, J
Regional expression of the ADAMs in developing chicken cochlea.
Dev Dyn
239
2256-65
2010
Gallus gallus
Yan, X; Lin, J; Rolfs, A; Luo, J
Differential expression of the ADAMs in developing chicken retina.
Dev Growth Differ
53
726-39
2011
Gallus gallus
Markus, A; Yan, X; Rolfs, A; Luo, J
Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development.
Cell Mol Biol Lett
16
431-51
2011
Gallus gallus
Pupovac, A; Foster, CM; Sluyter, R
Human P2X7 receptor activation induces the rapid shedding of CXCL16.
Biochem Biophys Res Commun
432
626-31
2013
Homo sapiens
Fadl, NN; Ahmed, HH; Booles, HF; Sayed, AH
Serrapeptase and nattokinase intervention for relieving Alzheimer's disease pathophysiology in rat model.
Hum Exp Toxicol
32
721-35
2013
Rattus, Hippocampus
McDonald, AJ; Dibble, JP; Evans, EG; Millhauser, GL
A new paradigm for enzymatic control of ?-cleavage and ?-cleavage of the prion protein.
J Biol Chem
289
803-13
2014
prion, Mus musculus
Pupovac, A; Geraghty, NJ; Watson, D; Sluyter, R
Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells.
Immunol Cell Biol
93
77-85
2015
Homo sapiens, Mus musculus, Mus sp.
Willem, M; Tahirovic, S; Busche, MA; Ovsepian, SV; Chafai, M; Kootar, S; Hornburg, D; Evans, LD; Moore, S; Daria, A; Hampel, H; Müller, V; Giudici, C; Nuscher, B; Wenninger-Weinzierl, A; Kremmer, E; Heneka, MT; Thal, DR; Giedraitis, V; Lannfelt, L; Müller, U; Livesey, FJ; Meissner, F; Herms, J; Konnerth, A; Marie, H; Haass, C
?-Secretase processing of APP inhibits neuronal activity in the hippocampus.
Nature
2015
Hippocampus, Homo sapiens, Mus musculus, Mus sp.
Spilman, PR; Corset, V; Gorostiza, O; Poksay, KS; Galvan, V; Zhang, J; Rao, R; Peters-Libeu, C; Vincelette, J; McGeehan, A; Dvorak-Ewell, M; Beyer, J; Campagna, J; Bankiewicz, K; Mehlen, P; John, V; Bredesen, DE
Netrin-1 Interrupts Amyloid-? Amplification, Increases sA?PP? in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease.
J Alzheimers Dis
52
223-42
2016
Homo sapiens, Mus sp., Rattus, Mus musculus
Kiesel, VA; Stan, SD
Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells.
Biochem Biophys Res Commun
484
833-838
2017
Homo sapiens
Yan, L; Deng, Y; Gao, J; Liu, Y; Li, F; Shi, J; Gong, Q
Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production.
Front Pharmacol
8
106
2017
Hippocampus
Couchie, D; Vaisman, B; Abderrazak, A; Mahmood, DFD; Hamza, MM; Canesi, F; Diderot, V; El Hadri, K; Nčgre-Salvayre, A; Le Page, A; Fulop, T; Remaley, AT; Rouis, M
Human Plasma Thioredoxin-80 Increases With Age and in ApoE(-/-) Mice Induces Inflammation, Angiogenesis, and Atherosclerosis.
Circulation
136
464-475
2017
Homo sapiens, Mus musculus, Mus sp.
Singh, BK; Vatsa, N; Kumar, V; Shekhar, S; Sharma, A; Jana, NR
Ube3a deficiency inhibits amyloid plaque formation in APPswe/PS1?E9 mouse model of Alzheimer's disease.
Hum Mol Genet
26
4042-4054
2017
Mus sp., Mus musculus
Sun, R; He, T; Pan, Y; Katusic, ZS
Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells.
Aging (Albany NY)
10
100-114
2018
Homo sapiens
Seike, S; Takehara, M; Kobayashi, K; Nagahama, M
Clostridium perfringens Delta-Toxin Damages the Mouse Small Intestine.
Toxins (Basel)
11
2019
Mus musculus
Ma, D; Li, Y; Zhu, Y; Wei, W; Zhang, L; Li, Y; Li, L; Zhang, L
Cornel Iridoid Glycoside Ameliorated Alzheimer's Disease-Like Pathologies and Necroptosis through RIPK1/MLKL Pathway in Young and Aged SAMP8 Mice.
Evid Based Complement Alternat Med
2021
9920962
2021
Mus sp.
Zhuo, JM; PraticĆ², D
Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet.
Exp Gerontol
45
195-201
2010
Mus sp.
Li, X; Lv, Y; Yu, S; Zhao, H; Yao, L
The effect of cadmium on A? levels in APP/PS1 transgenic mice.
Exp Ther Med
4
125-130
2012
Metazoa
Wang, CY; Zheng, W; Wang, T; Xie, JW; Wang, SL; Zhao, BL; Teng, WP; Wang, ZY
Huperzine A Activates Wnt/?-Catenin Signaling and Enhances the Nonamyloidogenic Pathway in an Alzheimer Transgenic Mouse Model.
Neuropsychopharmacology
36
1073-89
2011
Mus musculus
Wang, Y; Tang, XC; Zhang, HY
Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice.
J Neurosci Res
90
508-17
2012
Mus musculus
Hafez, HS; Ghareeb, DA; Saleh, SR; Abady, MM; El Demellawy, MA; Hussien, H; Abdel-Monem, N
Neuroprotective effect of ipriflavone against scopolamine-induced memory impairment in rats.
Psychopharmacology (Berl)
2017
Hippocampus
Berube, BJ; Bubeck Wardenburg, J
Staphylococcus aureus ?-toxin: nearly a century of intrigue.
Toxins (Basel)
5
1140-66
2013
Staphylococcus aureus, Homo sapiens
Laffont-Proust, I; Faucheux, BA; HƤssig, R; Sazdovitch, V; Simon, S; Grassi, J; Hauw, JJ; Moya, KL; HaĆÆk, S
The N-terminal cleavage of cellular prion protein in the human brain.
FEBS Lett
579
6333-7
2005
Homo sapiens, prion
Bourd-Boittin, K; Basset, L; Bonnier, D; L'helgoualc'h, A; Samson, M; ThƩret, N
CX3CL1/FRACTALKINE SHEDDING BY HUMAN HEPATIC STELLATE CELLS: CONTRIBUTION TO CHRONIC INFLAMMATION IN THE LIVER.
J Cell Mol Med
2009
Homo sapiens
Cooper, AM; Hobson, PS; Jutton, MR; Kao, MW; Drung, B; Schmidt, B; Fear, DJ; Beavil, AJ; McDonnell, JM; Sutton, BJ; Gould, HJ
Soluble CD23 Controls IgE Synthesis and Homeostasis in Human B Cells.
J Immunol
2012
Homo sapiens
Dornier, E; Coumailleau, F; Ottavi, JF; Moretti, J; Boucheix, C; Mauduit, P; Schweisguth, F; Rubinstein, E
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals.
J Cell Biol
199
481-96
2012
Homo sapiens, Diptera, Mammalia, Drosophila
Megra, BW; Eugenin, EA; Berman, JW
The Role of Shed PrP(c) in the Neuropathogenesis of HIV Infection.
J Immunol
199
224-232
2017
Homo sapiens
Bartz, JC
Underglycosylated prion protein modulates plaque formation in the brain.
J Clin Invest
130
1087-1089
2020
Mus musculus
Georgieva, E; Leber, SL; Wex, C; Garbers, C
Perturbation of the Actin Cytoskeleton in Human Hepatoma Cells Influences Interleukin-6 (IL-6) Signaling, but Not Soluble IL-6 Receptor Generation or NF-?B Activation.
Int J Mol Sci
22
2021
Homo sapiens
Osera, C; Fassina, L; Amadio, M; Venturini, L; Buoso, E; Magenes, G; Govoni, S; Ricevuti, G; Pascale, A
Cytoprotective Response Induced by Electromagnetic Stimulation on SH-SY5Y Human Neuroblastoma Cell Line.
Tissue Eng Part A
2011
Homo sapiens
Wiley, JC; Pettan-Brewer, C; Ladiges, WC
Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice.
Aging Cell
2011
Mus sp., Hippocampus, Mus musculus
Caixeta, ES; Sutton-McDowall, ML; Gilchrist, RB; Thompson, JG; Price, CA; Machado, MF; Lima, PF; Buratini, J
Bone morphogenetic protein 15 and fibroblast growth factor 10 enhance cumulus expansion, glucose uptake, and expression of genes in the ovulatory cascade during in vitro maturation of bovine cumulus-oocyte complexes.
Reproduction
146
27-35
2013
Bos taurus
Zhang, XL; Zhao, N; Xu, B; Chen, XH; Li, TJ
Treadmill exercise inhibits amyloid-? generation in the hippocampus of APP/PS1 transgenic mice by reducing cholesterol-mediated lipid raft formation.
Neuroreport
30
498-503
2019
Hippocampus, Mus sp.
Xu, YJ; Mei, Y; Qu, ZL; Zhang, SJ; Zhao, W; Fang, JS; Wu, J; Yang, C; Liu, SJ; Fang, YQ; Wang, Q; Zhang, YB
Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction.
Biomed Res Int
2018
4606752
2018
Mus sp.
Zhang, H; Gao, Y; Zhao, FL; Qiao, PF; Yan, Y
Hydrogen Sulfide-Induced Processing of the Amyloid Precursor Protein in SH-SY5Y Human Neuroblastoma Cells Involves the PI3-K/Akt Signaling Pathway.
Cell Mol Neurobiol
35
265-72
2015
Homo sapiens
Jordan, PM; Gerstmeier, J; Pace, S; Bilancia, R; Rao, Z; Börner, F; Miek, L; Gutiérrez-Gutiérrez, Ó; Arakandy, V; Rossi, A; Ialenti, A; Gonzįlez-Estévez, C; Löffler, B; Tuchscherr, L; Serhan, CN; Werz, O
Staphylococcus aureus-Derived ?-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution.
Cell Rep
33
108247
2020
Staphylococcus, Staphylococcus aureus, Homo sapiens, Mus musculus
Cao, K; Xiang, J; Dong, YT; Xu, Y; Li, Y; Song, H; Zeng, XX; Ran, LY; Hong, W; Guan, ZZ
Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation.
Alzheimers Res Ther
11
35
2019
Mus sp.
Feng, Z; Jia, X; Adams, MD; Ghosh, SK; Bonomo, RA; Weinberg, A
Epithelial innate immune response to Acinetobacter baumannii challenge.
Infect Immun
82
4458-65
2014
Acinetobacter baumannii, Homo sapiens
Beerli, C; Yakimovich, A; Kilcher, S; Reynoso, GV; Fläschner, G; Müller, DJ; Hickman, HD; Mercer, J
Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility.
Nat Microbiol
4
216-225
2019
Viruses
Postina, R; Schroeder, A; Dewachter, I; Bohl, J; Schmitt, U; Kojro, E; Prinzen, C; Endres, K; Hiemke, C; Blessing, M; Flamez, P; Dequenne, A; Godaux, E; van Leuven, F; Fahrenholz, F
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model.
J Clin Invest
113
1456-64
2004
Mus musculus, Homo sapiens, Mus sp.
Hou, Y; Yang, Q; Zhou, L; Du, X; Li, M; Yuan, M; Zhou, Z; Li, Z
Tetrahydroxystilbene glucoside improves learning and (or) memory ability of aged rats and may be connected to the APP pathway.
Can J Physiol Pharmacol
89
801-9
2011
Rattus
Anukulthanakorn, K; Malaivijitnond, S; Kitahashi, T; Jaroenporn, S; Parhar, I
Molecular events during the induction of neurodegeneration and memory loss in estrogen-deficient rats.
Gen Comp Endocrinol
181
316-23
2013
Hippocampus
Sharman, MJ; Moussavi Nik, SH; Chen, MM; Ong, D; Wijaya, L; Laws, SM; Taddei, K; Newman, M; Lardelli, M; Martins, RN; Verdile, G
The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes.
PLoS One
8
e66235
2013
Homo sapiens
Yang, C; Liu, Y; Ni, X; Li, N; Zhang, B; Fang, X
Enhancement of the nonamyloidogenic pathway by exogenous NGF in an Alzheimer transgenic mouse model.
Neuropeptides
48
233-8
2014
Mus musculus, Mus sp.
Panmanee, J; Nopparat, C; Chavanich, N; Shukla, M; Mukda, S; Song, W; Vincent, B; Govitrapong, P
Melatonin regulates the transcription of ?APP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells.
J Pineal Res
59
308-20
2015
Homo sapiens
Pliįssova, A; Lopes, JP; Lemos, C; Oliveira, CR; Cunha, RA; Agostinho, P
The Association of Amyloid-? Protein Precursor With ?- and ?-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.
Mol Neurobiol
2015
Mus musculus
Du, Y; Qu, J; Zhang, W; Bai, M; Zhou, Q; Zhang, Z; Li, Z; Miao, J
Morin reverses neuropathological and cognitive impairments in APPswe/PS1dE9 mice by targeting multiple pathogenic mechanisms.
Neuropharmacology
108
1-13
2016
Mus sp.
Cai, Z; Wang, C; He, W; Chen, Y
Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting ?/?-Secretases Activity and Enhancing ?-Secretases.
Curr Alzheimer Res
15
1045-1052
2018
Hippocampus, Mus sp.
Song, F; Liu, T; Meng, S; Li, F; Zhang, Y; Jiang, L
Insulin-Like Growth Factor-1 Alleviates Expression of A?1-40 and ?-, ?-, and ?-Secretases in the Cortex and Hippocampus of APP/PS1 Double Transgenic Mice.
J Mol Neurosci
66
595-603
2018
Mus musculus, Hippocampus, Mus sp.
Al-Atrache, Z; Lopez, DB; Hingley, ST; Appelt, DM
Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of ?-amyloid found in Alzheimer disease.
BMC Neurosci
20
6
2019
Chlamydia pneumoniae, Chlamydia, Homo sapiens
Fainanta, T; Jaroenporn, S; Wititsuwankul, P; Malaivijitnond, S
Chronological Molecular Changes in Neuronal Communication in Androgen-Deficient Rats.
J Mol Neurosci
69
83-93
2019
Rattus, Hippocampus
Dos Santos Guilherme, M; Stoye, NM; Rose-John, S; Garbers, C; Fellgiebel, A; Endres, K
The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients.
Front Aging Neurosci
11
182
2019
Homo sapiens, Mus musculus
Sun, H; Liu, M; Sun, T; Chen, Y; Lan, Z; Lian, B; Zhao, C; Liu, Z; Zhang, J; Liu, Y
Age-related changes in hippocampal AD pathology, actin remodeling proteins and spatial memory behavior of male APP/PS1 mice.
Behav Brain Res
376
112182
2019
Hippocampus, Mus sp.
Ren, J; Wang, X; Gao, Y; Wang, F; Guan, Z; Qi, X
The expression of the nicotinic acetylcholine receptor ?3 subunit in the brains of patients with Alzheimer's disease and its effects on ?- and ?-secretases and Notch signal transduction in SH-SY5Y cells.
Int J Clin Exp Pathol
12
3644-3652
2019
Homo sapiens
Li, Q; Jimenez-Krassel, F; Ireland, JJ; Smith, GW
Gene expression profiling of bovine preovulatory follicles: gonadotropin surge and prostanoid-dependent up-regulation of genes potentially linked to the ovulatory process.
Reproduction
137
297-307
2009
Candida dubliniensis
Khawam, K; Giron-Michel, J; Gu, Y; Perier, A; Giuliani, M; Caignard, A; Devocelle, A; Ferrini, S; Fabbi, M; Charpentier, B; Ludwig, A; Chouaib, S; Azzarone, B; Eid, P
Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition.
Cancer Res
69
1561-9
2009
Homo sapiens
Cissé, M; Duplan, E; Guillot-Sestier, MV; Rumigny, J; Bauer, C; Pagčs, G; Orzechowski, HD; Slack, BE; Checler, F; Vincent, B
The Extracellular Regulated Kinase-1 (ERK1) Controls Regulated {alpha}-Secretase-mediated Processing, Promoter Transactivation, and mRNA Levels of the Cellular Prion Protein.
J Biol Chem
286
29192-206
2011
prion
Mihi, B; Van Meulder, F; Rinaldi, M; Van Coppernolle, S; Chiers, K; Van den Broeck, W; Goddeeris, B; Vercruysse, J; Claerebout, E; Geldhof, P
Analysis of cell hyperplasia and parietal cell dysfunction induced by Ostertagia ostertagi infection.
Vet Res
44
121
2013
Ostertagia ostertagi
Erin, N; Türker, S; Elpek, Ö; Yildirim, B
ADAM proteases involved in inflammation are differentially altered in patients with gastritis or ulcer.
Exp Ther Med
15
1999-2005
2018
Homo sapiens
Tugutova, EA; Tamkovich, SN; Patysheva, MR; Afanasev, SG; Tsydenova, AA; Grigoreva, AE; Kolegova, ES; Kondakova, IV; Yunusova, NV
Relation between Tetraspanin- Associated and Tetraspanin- Non- Associated Exosomal Proteases and Metabolic Syndrome in Colorectal Cancer Patients
Asian Pac J Cancer Prev
20
809-815
2019
Homo sapiens
Ramon-Luing, LA; Ocańa-Guzman, R; Téllez-Navarrete, NA; Preciado-Garcķa, M; Romero-Rodrķguez, DP; Espinosa, E; Reyes-Terįn, G; Chavez-Galan, L
High Levels of TNF-? and TIM-3 as a Biomarker of Immune Reconstitution Inflammatory Syndrome in People with HIV Infection.
Life (Basel)
11
2021
Homo sapiens
Rooke, J; Pan, D; Xu, T; Rubin, GM
KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis.
Science
273
1227-31
1996
Drosophila
Lieber, T; Kidd, S; Young, MW
kuzbanian-mediated cleavage of Drosophila Notch.
Genes Dev
16
209-21
2002
Drosophila
Wijeyewickrema, LC; Berndt, MC; Andrews, RK
Snake venom probes of platelet adhesion receptors and their ligands.
Toxicon
45
1051-61
2005
snake
Lim, KT; Miyazaki, K; Kimura, N; Izawa, M; Kannagi, R
Clinical application of functional glycoproteomics - dissection of glycotopes carried by soluble CD44 variants in sera of patients with cancers.
Proteomics
8
3263-73
2008
Homo sapiens
Gutwein, P; Schramme, A; Sinke, N; Abdel-Bakky, MS; Voss, B; ObermĆ¼ller, N; Doberstein, K; Koziolek, M; Fritzsche, F; Johannsen, M; Jung, K; Schaider, H; Altevogt, P; Ludwig, A; Pfeilschifter, J; Kristiansen, G
Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients.
Eur J Cancer
45
478-89
2009
Homo sapiens
Andrzejewski, MG; Koelsch, A; Kogel, T; Dreymueller, D; Schwarz, N; Ludwig, A
Distinct role of the intracellular C-terminus for subcellular expression, shedding and function of the murine transmembrane chemokine CX3CL1.
Biochem Biophys Res Commun
395
178-84
2010
Mus musculus, Homo sapiens
Marcello, E; Epis, R; Saraceno, C; Gardoni, F; Borroni, B; Cattabeni, F; Padovani, A; Di Luca, M
SAP97-mediated local trafficking is altered in Alzheimer disease patients' hippocampus.
Neurobiol Aging
2010
Homo sapiens, Hippocampus
Sturgill, JL; Mathews, J; Scherle, P; Conrad, DH
Glutamate signaling through the kainate receptor enhances human immunoglobulin production.
J Neuroimmunol
233
80-89
2011
Homo sapiens
Parker, D; Prince, A
Immunopathogenesis of Staphylococcus aureus pulmonary infection.
Semin Immunopathol
34
281-97
2012
Staphylococcus aureus
Wentzell, JS; Bolkan, BJ; Carmine-Simmen, K; Swanson, TL; Musashe, DT; Kretzschmar, D
Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration.
Neurobiol Dis
46
78-87
2012
Homo sapiens
Lee, JH; Wittki, S; Bräu, T; Dreyer, FS; Krätzel, K; Dindorf, J; Johnston, IC; Gross, S; Kremmer, E; Zeidler, R; Schlötzer-Schrehardt, U; Lichtenheld, M; Saksela, K; Harrer, T; Schuler, G; Federico, M; Baur, AS
HIV Nef, Paxillin, and Pak1/2 Regulate Activation and Secretion of TACE/ADAM10 Proteases.
Mol Cell
49
668-79
2013
Human immunodeficiency virus 1
Nygaard, TK; Pallister, KB; Zurek, OW; Voyich, JM
The impact of ?-toxin on host cell plasma membrane permeability and cytokine expression during human blood infection by CA-MRSA USA300.
J Leukoc Biol
2013
Homo sapiens, Staphylococcus aureus
Becker, RE; Berube, BJ; Sampedro, GR; DeDent, AC; Bubeck Wardenburg, J
Tissue-specific patterning of host innate immune responses by Staphylococcus aureus ?-toxin.
J Innate Immun
6
619-31
2014
Staphylococcus aureus, Mus sp.
Endres, K; Fahrenholz, F; Lotz, J; Hiemke, C; Teipel, S; Lieb, K; Tüscher, O; Fellgiebel, A
Increased CSF APPs-? levels in patients with Alzheimer disease treated with acitretin.
Neurology
83
1930-5
2014
Homo sapiens
Bourdet, I; Preat, T; Goguel, V
The full-length form of the Drosophila amyloid precursor protein is involved in memory formation.
J Neurosci
35
1043-51
2015
Drosophila
Powers, ME; Bubeck Wardenburg, J
Host autophagy combating S. aureus: ?-toxin will be tolerated.
Cell Host Microbe
17
419-20
2015
Staphylococcus aureus
Powers, ME; Becker, RE; Sailer, A; Turner, JR; Bubeck Wardenburg, J
Synergistic Action of Staphylococcus aureus ?-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis.
Cell Host Microbe
17
775-87
2015
Staphylococcus aureus, Homo sapiens, Metazoa
Popov, LM; Marceau, CD; Starkl, PM; Lumb, JH; Shah, J; Guerrera, D; Cooper, RL; Merakou, C; Bouley, DM; Meng, W; Kiyonari, H; Takeichi, M; Galli, SJ; Bagnoli, F; Citi, S; Carette, JE; Amieva, MR
The adherens junctions control susceptibility to Staphylococcus aureus ?-toxin.
Proc Natl Acad Sci U S A
112
14337-42
2015
Staphylococcus aureus, Homo sapiens, Mus sp.
Xu, ZQ; Huang, H; Chen, YL; Gao, YY; Xu, J; Marshall, C; Cai, ZY; Xiao, M
Different Expression Patterns of Amyloid-? Protein Precursor Secretases in Human and Mouse Hippocampal Neurons: A Potential Contribution to Species Differences in Neuronal Susceptibility to Amyloid-? Pathogenesis.
J Alzheimers Dis
51
179-95
2016
Mus musculus, Mus sp., Hippocampus, Homo sapiens
Hofrichter, J; Krohn, M; Schumacher, T; Lange, C; Feistel, B; Walbroel, B; Pahnke, J
Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's ?-Amyloidosis Mouse Models and Aged C57Bl/6 Mice.
J Alzheimers Dis
53
967-80
2016
Mus sp.
Kobayakawa, T; Takahashi, N; Sobue, Y; Terabe, K; Ishiguro, N; Kojima, T
Mechanical stress loading induces CD44 cleavage in human chondrocytic HCS-2/8 cells.
Biochem Biophys Res Commun
478
1230-5
2016
Homo sapiens
Kuo, HW; Shih, CL; Tsung, JH; Liu, SW; Chu, SK; Yang, HC; Tsou, HH; Wang, ZH; Chen, AC; Liu, YL
Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome.
PLoS One
12
e0174647
2017
Human immunodeficiency virus 1
Wang, Z; Zhang, YH; Zhang, W; Gao, HL; Zhong, ML; Huang, TT; Guo, RF; Liu, NN; Li, DD; Li, Y; Wang, ZY; Zhao, P
Copper chelators promote nonamyloidogenic processing of A?PP via MT1/2 /CREB-dependent signaling pathways in A?PP/PS1 transgenic mice.
J Pineal Res
65
e12502
2018
Chelator
Triplett, KD; Pokhrel, S; Castleman, MJ; Daly, SM; Elmore, BO; Joyner, JA; Sharma, G; Herbert, G; Campen, MJ; Hathaway, HJ; Prossnitz, ER; Hall, PR
GPER activation protects against epithelial barrier disruption by Staphylococcus aureus ?-toxin.
Sci Rep
9
1343
2019
Homo sapiens
Jeong, Y; Ock, SA; Yoo, JG; Yu, DY; Choi, I
The Cxadr-Adam10 complex plays pivotal roles in tight junction integrity and early trophoblast development in mice.
Mol Reprod Dev
2019
coxsackievirus
Walkiewicz, K; Strzelczyk, J; Waniczek, D; Biernacki, K; Muc-Wierzgo?, M; Copija, A; Nowakowska-Zajdel, E
Adamalysines as Biomarkers and a Potential Target of Therapy in Colorectal Cancer Patients: Preliminary Results.
Dis Markers
2019
5035234
2019
Homo sapiens
Liu, J; Wang, Y; Wang, Z; Hao, Y; Bai, W; Wang, Z; Wang, J
5-Heptadecylresorcinol, a Biomarker for Whole Grain Rye Consumption, Ameliorates Cognitive Impairments and Neuroinflammation in APP/PS1 Transgenic Mice.
Mol Nutr Food Res
64
e1901218
2020
Mus musculus
Zheng, H; Li, J; Chen, Y; Gong, D; Wen, J; Mai, L; Zeng, Z
Effect of Lentivirus-Mediated miR-499a-3p on Human Umbilical Vein Endothelial Cells.
Biomed Res Int
2020
9372961
2020
Homo sapiens, Lentivirus
Asada-Utsugi, M; Uemura, K; Kubota, M; Noda, Y; Tashiro, Y; Uemura, TM; Yamakado, H; Urushitani, M; Takahashi, R; Hattori, S; Miyakawa, T; Ageta-Ishihara, N; Kobayashi, K; Kinoshita, M; Kinoshita, A
Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks.
Mol Brain
14
23
2021
Mus musculus
Farrar, JS; Lownik, JC; Way, GW; Rodriguez, MC; Celi, FS; Martin, RK
Identification of the transgene insertion site for an adipocyte-specific adiponectin-cre model and characterization of the functional consequences.
Adipocyte
10
91-100
2021
Mus musculus
Zhumanova, K; Lee, G; Baiseitova, A; Shah, AB; Kim, JH; Kim, JY; Lee, KW; Park, KH
Inhibitory mechanism of O-methylated quercetins, highly potent ?-secretase inhibitors isolated from Caragana balchaschensis (Kom.) Pojark.
J Ethnopharmacol
272
113935
2021
Caenorhabditis sinica
Wang, G; Zhou, HH; Luo, L; Qin, LQ; Yin, J; Yu, Z; Zhang, L; Wan, Z
Voluntary wheel running is capable of improving cognitive function only in the young but not the middle-aged male APPSwe/PS1De9 mice.
Neurochem Int
145
105010
2021
Mus sp., Bacteroides, Proteobacteria, Hippocampus, Allobaculum, Faecalibacterium, Phyla, Tenericutes
Liu, C; Cheng, ZY; Xia, QP; Hu, YH; Wang, C; He, L
GPR40 receptor agonist TAK-875 improves cognitive deficits and reduces ?-amyloid production in APPswe/PS1dE9 mice.
Psychopharmacology (Berl)
238
2133-2146
2021
Mus sp.
Ma, W; Zhang, J; Xu, K; Yan, S; Liu, D; Huang, H; Tang, Y; Yan, G; Sun, Y; Li, J; Zhang, W; Wang, C; Zhu, K; Lai, H
Plasma proteomic profiling reveals biomarkers associated with aortic dilation in patients with bicuspid aortic valve.
Ann Transl Med
9
1182
2021
Homo sapiens
Jiang, J; Wu, S; Wang, W; Chen, S; Peng, J; Zhang, X; Wu, Q
Ectodomain shedding and autocleavage of the cardiac membrane protease corin.
J Biol Chem
286
10066-72
2011
Homo sapiens
Gooden, MJ; Wiersma, VR; Boerma, A; Leffers, N; Boezen, HM; Ten Hoor, KA; Hollema, H; Walenkamp, AM; Daemen, T; Nijman, HW; Bremer, E
Elevated serum CXCL16 is an independent predictor of poor survival in ovarian cancer and may reflect pro-metastatic ADAM protease activity.
Br J Cancer
110
1535-44
2014
Homo sapiens
Araya, HF; Sepulveda, H; Lizama, CO; Vega, OA; Jerez, S; Briceńo, PF; Thaler, R; Riester, SM; Antonelli, M; Salazar-Onfray, F; Rodrķguez, JP; Moreno, RD; Montecino, M; Charbonneau, M; Dubois, CM; Stein, GS; van Wijnen, AJ; Galindo, MA
Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2.
J Cell Biochem
2018
Homo sapiens
Bakken, AM; Protack, CD; Roztocil, E; Nicholl, SM; Davies, MG
Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism.
J Vasc Surg
49
1296-303
2009
Homo sapiens
Liu, PC; Liu, X; Li, Y; Covington, M; Wynn, R; Huber, R; Hillman, M; Yang, G; Ellis, D; Marando, C; Katiyar, K; Bradley, J; Abremski, K; Stow, M; Rupar, M; Zhuo, J; Li, YL; Lin, Q; Burns, D; Xu, M; Zhang, C; Qian, DQ; He, C; Sharief, V; Weng, L; Agrios, C; Shi, E; Metcalf, B; Newton, R; Friedman, S; Yao, W; Scherle, P; Hollis, G; Burn, TC
Identification of ADAM10 as a Major Source of HER2 Ectodomain Sheddase Activity in HER2 Overexpressing Breast Cancer Cells.
Cancer Biol Ther
5
657-64
2006
Homo sapiens
Hwang, EM; Kim, SK; Sohn, JH; Lee, JY; Kim, Y; Kim, YS; Mook-Jung, I
Furin is an endogenous regulator of alpha-secretase associated APP processing.
Biochem Biophys Res Commun
349
654-9
2006
Homo sapiens, Mus sp.
Stamenkovic, I; Yu, Q
Shedding light on proteolytic cleavage of CD44: the responsible sheddase and functional significance of shedding.
J Invest Dermatol
129
1321-4
2009
Homo sapiens
Tsachaki, M; Serlidaki, D; Fetani, A; Zarkou, V; Rozani, I; Ghiso, J; Efthimiopoulos, S
Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.
Glycobiology
2011
Ursidae
Prox, J; Willenbrock, M; Weber, S; Lehmann, T; Schmidt-Arras, D; Schwanbeck, R; Saftig, P; Schwake, M
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.
Cell Mol Life Sci
69
2919-32
2012
Saccharomyces cerevisiae
Huang, Y; Benaich, N; Tape, C; Kwok, HF; Murphy, G
Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation.
Int J Biol Sci
10
702-14
2014
Homo sapiens
Tosetti, F; Venč, R; Camodeca, C; Nuti, E; Rossello, A; D'Arrigo, C; Galante, D; Ferrari, N; Poggi, A; Zocchi, MR
Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells.
Oncoimmunology
7
e1421889
2018
Homo sapiens
Yoneyama, T; Gorry, M; Sobo-Vujanovic, A; Lin, Y; Vujanovic, L; Gaither-Davis, A; Moss, ML; Miller, MA; Griffith, LG; Lauffenburger, DA; Stabile, LP; Herman, J; Vujanovic, NL
ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker.
J Cancer
9
2559-2570
2018
Homo sapiens
Reinhardt, S; Schuck, F; Stoye, N; Hartmann, T; Grimm, MOW; Pflugfelder, G; Endres, K
Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.
Cell Mol Life Sci
2019
Homo sapiens, Drosophila
Bleibaum, F; Sommer, A; Veit, M; Rabe, B; Andrä, J; Kunzelmann, K; Nehls, C; Correa, W; Gutsmann, T; Grötzinger, J; Bhakdi, S; Reiss, K
ADAM10 sheddase activation is controlled by cell membrane asymmetry.
J Mol Cell Biol
2019
Homo sapiens
Mattila, SO; Tuhkanen, HE; Lackman, JJ; Konzack, A; Morató, X; Argerich, J; Saftig, P; Ciruela, F; Petäjä-Repo, UE
GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin.
FASEB J
35
e21654
2021
Hippocampus, Homo sapiens, Mus musculus
Bertram, A; Lovric, S; Engel, A; Beese, M; Wyss, K; Hertel, B; Park, JK; Becker, JU; Kegel, J; Haller, H; Haubitz, M; Kirsch, T
Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis.
J Am Soc Nephrol
26
2860-70
2015
Homo sapiens
Jefferson, T; Auf dem Keller, U; Bellac, C; Metz, VV; Broder, C; Hedrich, J; Ohler, A; Maier, W; Magdolen, V; Sterchi, E; Bond, JS; Jayakumar, A; Traupe, H; Chalaris, A; Rose-John, S; Pietrzik, CU; Postina, R; Overall, CM; Becker-Pauly, C
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin ? and ADAM10.
Cell Mol Life Sci
2012
Homo sapiens, Mus musculus, Mus sp.
Kim, YH; Jung, JC
Suppression of tunicamycin-induced CD44v6 ectodomain shedding and apoptosis is correlated with temporal expression patterns of active ADAM10, MMP-9 and MMP-13 proteins in Caki-2 renal carcinoma cells.
Oncol Rep
28
1869-74
2012
Homo sapiens
Lammich, S; Kojro, E; Postina, R; Gilbert, S; Pfeiffer, R; Jasionowski, M; Haass, C; Fahrenholz, F
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.
Proc Natl Acad Sci U S A
96
3922-7
1999
Homo sapiens
Gough, PJ; Garton, KJ; Wille, PT; Rychlewski, M; Dempsey, PJ; Raines, EW
A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16.
J Immunol
172
3678-85
2004
Bacteria, Mus musculus
Hundhausen, C; Schulte, A; Schulz, B; Andrzejewski, MG; Schwarz, N; von Hundelshausen, P; Winter, U; Paliga, K; Reiss, K; Saftig, P; Weber, C; Ludwig, A
Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes.
J Immunol
178
8064-72
2007
Mus musculus
Koenen, RR; Pruessmeyer, J; Soehnlein, O; Fraemohs, L; Zernecke, A; Schwarz, N; Reiss, K; Sarabi, A; Lindbom, L; Hackeng, TM; Weber, C; Ludwig, A
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.
Blood
113
4799-809
2009
Mus musculus, Mus sp.
Manzine, PR; Barham, EJ; Vale, FA; Selistre-de-Araśjo, HS; Pavarini, SC; Cominetti, MR
Platelet a disintegrin and metallopeptidase 10 expression correlates with clock drawing test scores in Alzheimer's disease.
Int J Geriatr Psychiatry
2013
Homo sapiens
Möller-Hackbarth, K; Dewitz, C; Schweigert, O; Trad, A; Garbers, C; Rose-John, S; Scheller, J
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3).
J Biol Chem
288
34529-44
2013
Mus musculus
Folgosa, L; Zellner, HB; El Shikh, ME; Conrad, DH
Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-? shedding.
J Immunol
191
5951-8
2013
Mus sp.
Schweigert, O; Dewitz, C; Möller-Hackbarth, K; Trad, A; Garbers, C; Rose-John, S; Scheller, J
Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine.
Biochim Biophys Acta
1843
275-87
2014
Mus musculus, Homo sapiens
Zhang, W; Liu, S; Liu, K; Wang, Y; Ji, B; Zhang, X; Liu, Y
A disintegrin and metalloprotease (ADAM)10 is highly expressed in hepatocellular carcinoma and is associated with tumour progression.
J Int Med Res
2014
Homo sapiens
van der Vorst, EP; Jeurissen, M; Wolfs, IM; Keijbeck, A; Theodorou, K; Wijnands, E; Schurgers, L; Weber, S; Gijbels, MJ; Hamers, AA; Dreymueller, D; Rose-John, S; de Winther, MP; Ludwig, A; Saftig, P; Biessen, EA; Donners, MM
Myeloid A Disintegrin and Metalloproteinase Domain 10 Deficiency Modulates Atherosclerotic Plaque Composition by Shifting the Balance from Inflammation toward Fibrosis.
Am J Pathol
2015
Mus sp.
Isozaki, T; Ishii, S; Nishimi, S; Nishimi, A; Oguro, N; Seki, S; Miura, Y; Miwa, Y; Oh, K; Toyoshima, Y; Nakamura, M; Inagaki, K; Kasama, T
A disintegrin and metalloprotease-10 is correlated with disease activity and mediates monocyte migration and adhesion in rheumatoid arthritis.
Transl Res
166
244-53
2015
Homo sapiens, Sandfly fever Sicilian virus
Schumacher, N; Meyer, D; Mauermann, A; von der Heyde, J; Wolf, J; Schwarz, J; Knittler, K; Murphy, G; Michalek, M; Garbers, C; Bartsch, JW; Guo, S; Schacher, B; Eickholz, P; Chalaris, A; Rose-John, S; Rabe, B
Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles.
J Biol Chem
290
26059-71
2015
Homo sapiens, Mus musculus, Mus sp.
Toonen, JA; Ronchetti, A; Sidjanin, DJ
A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development.
PLoS One
11
e0156184
2016
Mus sp., Lamiinae
Isozaki, T; Nishimi, S; Nishimi, A; Saito, M; Miwa, Y; Toyoshima, Y; Inagaki, K; Kasama, T
A disintegrin and metalloproteinase (ADAM)-10 as a predictive factor for tocilizumab effectiveness in rheumatoid arthritis.
Mod Rheumatol
1-5
2016
Homo sapiens
Oh, S; Park, Y; Lee, HJ; Lee, J; Lee, SH; Baek, YS; Chun, SK; Lee, SM; Kim, M; Chon, YE; Ha, Y; Cho, Y; Kim, GJ; Hwang, SG; Kwack, K
A Disintegrin and Metalloproteinase 9 (ADAM9) in Advanced Hepatocellular Carcinoma and Their Role as a Biomarker During Hepatocellular Carcinoma Immunotherapy.
Cancers (Basel)
12
2020
Homo sapiens
Hsia, HE; Tüshaus, J; Feng, X; Hofmann, LI; Wefers, B; Marciano, DK; Wurst, W; Lichtenthaler, SF
Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons.
FASEB J
35
e21813
2021
Mus musculus
Hoe, HS; Cooper, MJ; Burns, MP; Lewis, PA; van der Brug, M; Chakraborty, G; Cartagena, CM; Pak, DT; Cookson, MR; Rebeck, GW
The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis.
J Neurosci
27
10895-905
2007
Homo sapiens, Mus musculus
Bulstrode, H; Jones, LM; Siney, EJ; Sampson, JM; Ludwig, A; Gray, WP; Willaime-Morawek, S
A-Disintegrin and Metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells.
Cancer Lett
326
79-87
2012
Homo sapiens
Brennaman, LH; Moss, ML; Maness, PF
EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease.
J Neurochem
128
267-79
2014
Mus sp., Mus musculus
Miyazaki, T; Ikeda, K; Horie-Inoue, K; Inoue, S
Amyloid precursor protein regulates migration and metalloproteinase gene expression in prostate cancer cells.
Biochem Biophys Res Commun
452
828-33
2014
Homo sapiens
Saftig, P; Lichtenthaler, SF
The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.
Prog Neurobiol
135
1-20
2015
Mus sp.
Zhu, X; Li, X; Zhu, M; Xu, K; Yang, L; Han, B; Huang, R; Zhang, A; Yao, H
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation.
J Neuroinflammation
15
221
2018
Mus musculus, Mus sp., Hippocampus
Cheng, W; Meng, W; Gu, Y
Metalloprotease Adam10 inhibition mitigates acute liver injury via repression of intrahepatic inflammation.
Minerva Med
2020
Mus musculus, Mus sp., Lentivirus
Jones, BA; Riegsecker, S; Rahman, A; Beamer, M; Aboualaiwi, W; Khuder, SA; Ahmed, S
Role of ADAM17, p38 MAPK, cathepsins, and proteasome pathway in the synthesis and shedding of fractalkine/CX3CL1 in rheumatoid arthritis.
Arthritis Rheum
2013
Homo sapiens, Rattus
Holthoewer, D; Endres, K; Schuck, F; Hiemke, C; Schmitt, U; Fahrenholz, F
Acitretin, an Enhancer of Alpha-Secretase Expression, Crosses the Blood-Brain Barrier and Is Not Eliminated by P-Glycoprotein.
Neurodegener Dis
2012
Homo sapiens, Mus musculus, Mus sp.
Liu, W; Li, J; Zhang, P; Hou, Q; Feng, S; Liu, L; Cui, D; Shi, H; Fu, Y; Luo, Y
A novel pan-cancer biomarker plasma heat shock protein 90alpha and its diagnosis determinants in clinic.
Cancer Sci
110
2941-2959
2019
Homo sapiens
Liu, S; Zhang, W; Liu, K; Wang, Y; Ji, B; Liu, Y
Synergistic effects of co-expression plasmid?based ADAM10-specific siRNA and GRIM-19 on hepatocellular carcinoma in vitro and in vivo.
Oncol Rep
32
2501-10
2014
Mus musculus
Wilson, RL; Troja, W; Sumser, EK; Maupin, A; Lampe, K; Jones, HN
Insulin-like growth factor 1 signaling in the placenta requires endothelial nitric oxide synthase to support trophoblast function and normal fetal growth.
Am J Physiol Regul Integr Comp Physiol
320
R653-R662
2021
Homo sapiens, Mus musculus
Loesch, K; Deng, L; Cowan, JW; Wang, X; He, K; Jiang, J; Black, RA; Frank, SJ
Janus kinase 2 influences growth hormone receptor metalloproteolysis.
Endocrinology
147
2839-49
2006
Homo sapiens, Mus sp.
Swendeman, S; Mendelson, K; Weskamp, G; Horiuchi, K; Deutsch, U; Scherle, P; Hooper, A; Rafii, S; Blobel, CP
VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling.
Circ Res
103
916-8
2008
Homo sapiens
Salaita, K; Nair, PM; Petit, RS; Neve, RM; Das, D; Gray, JW; Groves, JT
Restriction of receptor movement alters cellular response: physical force sensing by EphA2.
Science
327
1380-5
2010
Homo sapiens
Oshima, H; Popivanova, BK; Oguma, K; Kong, D; Ishikawa, TO; Oshima, M
Activation of epidermal growth factor receptor signaling by the prostaglandin E(2) receptor EP4 pathway during gastric tumorigenesis.
Cancer Sci
102
713-9
2011
Mus musculus
Mohanan, V; Temburni, MK; Kappes, JC; Galileo, DS
L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor.
Clin Exp Metastasis
2012
Homo sapiens
Chalupskż, K; Kanchev, I; bodįkovį, O; Buryovį, H; Jiroukovį, M; Ko?ķnek, V; Gregor, M; Sedlį?ek, R
ADAM10/17-dependent release of soluble c-Met correlates with hepatocellular damage.
Folia Biol (Praha)
59
76-86
2013
Homo sapiens, Mus musculus, Indicator
Pischedda, F; Piccoli, G
The IgLON Family Member Negr1 Promotes Neuronal Arborization Acting as Soluble Factor via FGFR2.
Front Mol Neurosci
8
89
2015
Mus musculus
Orme, JJ; Du, Y; Vanarsa, K; Mayeux, J; Li, L; Mutwally, A; Arriens, C; Min, S; Hutcheson, J; Davis, LS; Chong, BF; Satterthwaite, AB; Wu, T; Mohan, C
Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE.
Clin Immunol
169
58-68
2016
Homo sapiens, Mus sp.
Dixit, G; Schanz, W; Pappas, BA; Maretzky, T
Members of the Fibroblast Growth Factor Receptor Superfamily Are Proteolytically Cleaved by Two Differently Activated Metalloproteases.
Int J Mol Sci
22
2021
Mus musculus
Zbodakova, O; Chalupsky, K; Sarnova, L; Kasparek, P; Jirouskova, M; Gregor, M; Sedlacek, R
ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis.
Sci Rep
11
11414
2021
Mus sp.
Webster, NJ; Green, KN; Settle, VJ; Peers, C; Vaughan, PF
Altered processing of the amyloid precursor protein and decreased expression of ADAM 10 by chronic hypoxia in SH-SY5Y: no role for the stress-activated JNK and p38 signalling pathways.
Brain Res Mol Brain Res
130
161-9
2004
Homo sapiens
Urriola-Muńoz, P; Lagos-Cabré, R; Moreno, RD
A mechanism of male germ cell apoptosis induced by bisphenol-A and nonylphenol involving ADAM17 and p38 MAPK activation.
PLoS One
9
e113793
2014
Rattus
Hartmann, D; de Strooper, B; Serneels, L; Craessaerts, K; Herreman, A; Annaert, W; Umans, L; LĆ¼bke, T; Lena Illert, A; von Figura, K; Saftig, P
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Hum Mol Genet
11
2615-24
2002
vertebrata, Mus musculus, Mus sp.
LaVoie, MJ; Selkoe, DJ
The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments.
J Biol Chem
278
34427-37
2003
Drosophila
CissƩ, MA; Gandreuil, C; Hernandez, JF; Martinez, J; Checler, F; Vincent, B
Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of alpha-secretase.
Biochem Biophys Res Commun
347
254-60
2006
Homo sapiens, prion
Fahrenholz, F; Postina, R
Alpha-secretase activation--an approach to Alzheimer's disease therapy.
Neurodegener Dis
3
255-61
2006
Homo sapiens
Fahrenholz, F
Alpha-secretase as a therapeutic target.
Curr Alzheimer Res
4
412-7
2007
Homo sapiens, Mus musculus, Areas
Yang, HQ; Sun, ZK; Ba, MW; Xu, J; Xing, Y
Involvement of protein trafficking in deprenyl-induced alpha-secretase activity regulation in PC12 cells.
Eur J Pharmacol
610
37-41
2009
Anser
Mei, Z; Situ, B; Tan, X; Zheng, S; Zhang, F; Yan, P; Liu, P
Cryptotanshinione upregulates alpha-secretase by activation PI3K pathway in cortical neurons.
Brain Res
1348
165-73
2010
Homo sapiens, Salvia miltiorrhiza
Donmez, G; Wang, D; Cohen, DE; Guarente, L
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
Cell
142
320-32
2010
Mus musculus
Kuhn, PH; Wang, H; Dislich, B; Colombo, A; Zeitschel, U; Ellwart, JW; Kremmer, E; Rossner, S; Lichtenthaler, SF
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.
EMBO J
29
3020-32
2010
Mus musculus
Endres, K; Fahrenholz, F
Regulation of alpha-secretase ADAM10 expression and activity.
Exp Brain Res
2011
Homo sapiens
Prox, J; Rittger, A; Saftig, P
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin.
Exp Brain Res
2011
Mus sp., Mus musculus
Gil-Bea, F; Akterin, S; Persson, T; Mateos, L; Sandebring, A; Avila-Carińo, J; Gutierrez-Rodriguez, A; Sundström, E; Holmgren, A; Winblad, B; Cedazo-Minguez, A
Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer's disease brain.
EMBO Mol Med
2012
Homo sapiens
Sarno, TA; Talib, LL; Joaquim, HP; Bram, JM; Gattaz, WF; Forlenza, OV
Protein Expression of BACE1 is Downregulated by Donepezil in Alzheimer's Disease Platelets.
J Alzheimers Dis
55
1445-1451
2017
Homo sapiens
Wang, X; Wang, C; Pei, G
?-Secretase ADAM10 physically interacts with ?-secretase BACE1 in neurons and regulates CHL1 proteolysis.
J Mol Cell Biol
2018
Mus musculus
Rosendahl, MS; Ko, SC; Long, DL; Brewer, MT; Rosenzweig, B; Hedl, E; Anderson, L; Pyle, SM; Moreland, J; Meyers, MA; Kohno, T; Lyons, D; Lichenstein, HS
Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases.
J Biol Chem
272
24588-93
1997
Homo sapiens
Moss, ML; Rasmussen, FH
Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening.
Anal Biochem
366
144-8
2007
Homo sapiens
Esselens, CW; Malapeira, J; ColomƩ, N; Moss, M; Canals, F; Arribas, J
Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17.
Biol Chem
2008
Mink cell focus-forming virus
Tucher, J; Linke, D; Koudelka, T; Cassidy, L; Tredup, C; Wichert, R; Pietrzik, C; Becker-Pauly, C; Tholey, A
LC-MS Based Cleavage Site Profiling of the Proteases ADAM10 and ADAM17 Using Proteome-Derived Peptide Libraries.
J Proteome Res
13
2205-14
2014
Mus musculus, Saccharomyces cerevisiae
Pruessmeyer, J; Hess, FM; Alert, H; Groth, E; Pasqualon, T; Schwarz, N; Nyamoya, S; Kollert, J; van der Vorst, E; Donners, M; Martin, C; Uhlig, S; Saftig, P; Dreymueller, D; Ludwig, A
Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space.
Blood
123
4077-88
2014
Homo sapiens, Mus sp., Mus musculus
Caolo, V; Swennen, G; Chalaris, A; Wagenaar, A; Verbruggen, S; Rose-John, S; Molin, DG; Vooijs, M; Post, MJ
ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis.
Angiogenesis
18
13-22
2015
Mus musculus, Mus sp.
Shukla, M; Htoo, HH; Wintachai, P; Hernandez, JF; Dubois, C; Postina, R; Xu, H; Checler, F; Smith, DR; Govitrapong, P; Vincent, B
Melatonin stimulates the nonamyloidogenic processing of ?APP through the positive transcriptional regulation of ADAM10 and ADAM17.
J Pineal Res
58
151-65
2015
Homo sapiens, Mus musculus
Park, GB; Kim, D; Kim, YS; Kim, JW; Sun, H; Roh, KH; Yang, JW; Hur, DY
Regulation of ADAM10 and ADAM17 by Sorafenib Inhibits Epithelial-to-Mesenchymal Transition in Epstein-Barr Virus-Infected Retinal Pigment Epithelial Cells.
Invest Ophthalmol Vis Sci
56
5162-73
2015
Human gammaherpesvirus 4
Bae, WY; Park, SK; Kim, DH; Koh, TK; Hur, DY; Chueh, HW
Expression of ADAM17 and ADAM10 in nasal polyps.
Int Forum Allergy Rhinol
2016
Homo sapiens
Buchanan, PC; Boylan, KLM; Walcheck, B; Heinze, R; Geller, MA; Argenta, PA; Skubitz, APN
Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17.
J Biol Chem
292
6339-6351
2017
Homo sapiens
Camodeca, C; Nuti, E; Tosetti, F; Poggi, A; D'Arrigo, C; Zocchi, MR; Rossello, A
Synthesis and in vitro Evaluation of ADAM10 and ADAM17 Highly Selective Bioimaging Probes.
ChemMedChem
13
2119-2131
2018
Homo sapiens
Orme, JJ; Jazieh, KA; Xie, T; Harrington, S; Liu, X; Ball, M; Madden, B; Charlesworth, MC; Azam, TU; Lucien, F; Wootla, B; Li, Y; Villasboas, JC; Mansfield, AS; Dronca, RS; Dong, H
ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance.
Oncoimmunology
9
1744980
2020
Homo sapiens
Zheng, Y; Verhoeff, TA; Perez Pardo, P; Garssen, J; Kraneveld, AD
The Gut-Brain Axis in Autism Spectrum Disorder: A Focus on the Metalloproteases ADAM10 and ADAM17.
Int J Mol Sci
22
2020
Homo sapiens
Abu El-Asrar, AM; Nawaz, MI; Ahmad, A; De Zutter, A; Siddiquei, MM; Blanter, M; Allegaert, E; Gikandi, PW; De Hertogh, G; Van Damme, J; Opdenakker, G; Struyf, S
Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy.
Front Immunol
11
601639
2020
Homo sapiens
Alabi, RO; Lora, J; Celen, AB; Maretzky, T; Blobel, CP
Analysis of the Conditions That Affect the Selective Processing of Endogenous Notch1 by ADAM10 and ADAM17.
Int J Mol Sci
22
2021
Mus musculus
Seidel, J; Leitzke, S; Ahrens, B; Sperrhacke, M; Bhakdi, S; Reiss, K
Role of ADAM10 and ADAM17 in Regulating CD137 Function.
Int J Mol Sci
22
2021
Homo sapiens
Min, Z; Tang, Y; Hu, XT; Zhu, BL; Ma, YL; Zha, JS; Deng, XJ; Yan, Z; Chen, GJ
Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5'UTR and PI3K Signaling.
Front Mol Neurosci
11
198
2018
Homo sapiens, Mus musculus
Howard, L; Lu, X; Mitchell, S; Griffiths, S; Glynn, P
Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types.
Biochem J
317 ( Pt 1)
45-50
1996
Bos taurus
Dallas, DJ; Genever, PG; Patton, AJ; Millichip, MI; McKie, N; Skerry, TM
Localization of ADAM10 and Notch receptors in bone.
Bone
25
9-15
1999
Drosophila, Drosophila melanogaster, Homo sapiens, Rattus
Amour, A; Knight, CG; Webster, A; Slocombe, PM; Stephens, PE; KnƤuper, V; Docherty, AJ; Murphy, G
The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3.
FEBS Lett
473
275-9
2000
Homo sapiens
Hundhausen, C; Misztela, D; Berkhout, TA; Broadway, N; Saftig, P; Reiss, K; Hartmann, D; Fahrenholz, F; Postina, R; Matthews, V; Kallen, KJ; Rose-John, S; Ludwig, A
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Blood
102
1186-95
2003
Mus musculus
Plamont, MA; Chasseigneaux, S; Delasnerie-LauprĆŖtre, N; Beaudry, P; Peoc'h, K; Laplanche, JL
Variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease.
Neurosci Lett
344
132-4
2003
Homo sapiens, prion
Colciaghi, F; Marcello, E; Borroni, B; Zimmermann, M; Caltagirone, C; Cattabeni, F; Padovani, A; Di Luca, M
Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease.
Neurology
62
498-501
2004
Homo sapiens
Abel, S; Hundhausen, C; Mentlein, R; Schulte, A; Berkhout, TA; Broadway, N; Hartmann, D; Sedlacek, R; Dietrich, S; Muetze, B; Schuster, B; Kallen, KJ; Saftig, P; Rose-John, S; Ludwig, A
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
J Immunol
172
6362-72
2004
Mus musculus, Homo sapiens, Mus sp.
Manilay, JO; Anderson, AC; Kang, C; Robey, EA
Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, delta-1.
J Immunol
174
6732-41
2005
Mus sp.
Weskamp, G; Ford, JW; Sturgill, J; Martin, S; Docherty, AJ; Swendeman, S; Broadway, N; Hartmann, D; Saftig, P; Umland, S; Sehara-Fujisawa, A; Black, RA; Ludwig, A; Becherer, JD; Conrad, DH; Blobel, CP
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
Nat Immunol
7
1293-8
2006
Mus sp.
Bell, KF; Zheng, L; Fahrenholz, F; Cuello, AC
ADAM-10 over-expression increases cortical synaptogenesis.
Neurobiol Aging
29
554-65
2008
Mus musculus, Metazoa, Homo sapiens
Muraguchi, T; Takegami, Y; Ohtsuka, T; Kitajima, S; Chandana, EP; Omura, A; Miki, T; Takahashi, R; Matsumoto, N; Ludwig, A; Noda, M; Takahashi, C
RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity.
Nat Neurosci
10
838-45
2007
Mus musculus
Chen, YY; Hehr, CL; Atkinson-Leadbeater, K; Hocking, JC; McFarlane, S
Targeting of retinal axons requires the metalloproteinase ADAM10.
J Neurosci
27
8448-56
2007
Xenopus
Schramme, A; Abdel-Bakky, MS; Gutwein, P; ObermĆ¼ller, N; Baer, PC; Hauser, IA; Ludwig, A; Gauer, S; SchƤfer, L; Sobkowiak, E; Altevogt, P; Koziolek, M; Kiss, E; Grƶne, HJ; Tikkanen, R; Goren, I; Radeke, H; Pfeilschifter, J
Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney.
Kidney Int
74
328-38
2008
Homo sapiens
Tian, L; Wu, X; Chi, C; Han, M; Xu, T; Zhuang, Y
ADAM10 is essential for proteolytic activation of Notch during thymocyte development.
Int Immunol
20
1181-7
2008
Mus musculus, Drosophila
Jangouk, P; Dehmel, T; Meyer Zu Hƶrste, G; Ludwig, A; Lehmann, HC; Kieseier, BC
Involvement of ADAM10 in axonal outgrowth and myelination of the peripheral nerve.
Glia
57
1765-1774
2009
Rattus
Hikita, A; Tanaka, N; Yamane, S; Ikeda, Y; Furukawa, H; Tohma, S; Suzuki, R; Tanaka, S; Mitomi, H; Fukui, N
Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alpha.
Biochem Cell Biol
87
581-93
2009
Homo sapiens, Mus musculus
Kohga, K; Takehara, T; Tatsumi, T; Miyagi, T; Ishida, H; Ohkawa, K; Kanto, T; Hiramatsu, N; Hayashi, N
Anticancer Chemotherapy Inhibits MHC Class I-Related Chain A Ectodomain Shedding by Downregulating ADAM10 Expression in Hepatocellular Carcinoma.
Cancer Res
69
8050-7
2009
Homo sapiens
Lee, SB; Schramme, A; Doberstein, K; Dummer, R; Abdel-Bakky, MS; Keller, S; Altevogt, P; Oh, ST; Reichrath, J; Oxmann, D; Pfeilschifter, J; Mihic-Probst, D; Gutwein, P
ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma.
J Invest Dermatol
2009
Homo sapiens
Lammich, S; Buell, D; Zilow, S; Ludwig, AK; Nuscher, B; Lichtenthaler, SF; Prinzen, C; Fahrenholz, F; Haass, C
Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region.
J Biol Chem
2010
animal
Saitoh, H; Leopold, PL; Harvey, BG; O'Connor, TP; Worgall, S; Hackett, NR; Crystal, RG
Emphysema mediated by lung overexpression of ADAM10.
Clin Transl Sci
2
50-6
2009
Homo sapiens, Mus musculus, Mus sp.
Zhang, S; Salemi, J; Hou, H; Zhu, Y; Mori, T; Giunta, B; Obregon, D; Tan, J
Rapamycin promotes beta-amyloid production via ADAM-10 inhibition.
Biochem Biophys Res Commun
398
337-41
2010
Homo sapiens, Mus musculus, Mus sp.
Gordon, GM; Austin, JS; Sklar, AL; Feuer, WJ; Lagier, AJ; Fini, ME
Comprehensive gene expression profiling and functional analysis of matrix metalloproteinases and TIMPs, and identification of ADAM-10 gene expression, in a corneal model of epithelial resurfacing.
J Cell Physiol
2010
Mus musculus
Rose, AA; Annis, MG; Dong, Z; Pepin, F; Hallett, M; Park, M; Siegel, PM
ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties.
PLoS One
5
e12093
2010
Homo sapiens, Mus musculus
Zhang, C; Tian, L; Chi, C; Wu, X; Yang, X; Han, M; Xu, T; Zhuang, Y; Deng, K
Adam10 is essential for early embryonic cardiovascular development.
Dev Dyn
239
2594-602
2010
Mus sp., Drosophila
Epis, R; Marcello, E; Gardoni, F; Vastagh, C; Malinverno, M; Balducci, C; Colombo, A; Borroni, B; Vara, H; Dell'Agli, M; Cattabeni, F; Giustetto, M; Borsello, T; Forloni, G; Padovani, A; Di Luca, M
Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease.
Brain
133
3323-35
2010
Mus musculus, animal
Donners, MM; Wolfs, IM; Olieslagers, S; Mohammadi-Motahhari, Z; Tchaikovski, V; Heeneman, S; van Buul, JD; Caolo, V; Molin, DG; Post, MJ; Waltenberger, J
A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis.
Arterioscler Thromb Vasc Biol
30
2188-95
2010
Homo sapiens
Fernandez, JW; Rezai-Zadeh, K; Obregon, D; Tan, J
EGCG functions through estrogen receptor-mediated activation of ADAM10 in the promotion of non-amyloidogenic processing of APP.
FEBS Lett
584
4259-67
2010
Mus sp.
Xu, Q; Liu, X; Chen, W; Zhang, Z
Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference.
J Transl Med
8
136
2010
Homo sapiens
Weber, S; Niessen, MT; Prox, J; Lüllmann-Rauch, R; Schmitz, A; Schwanbeck, R; Blobel, CP; Jorissen, E; de Strooper, B; Niessen, CM; Saftig, P
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling.
Development
138
495-505
2011
Mus sp.
Gibb, DR; Saleem, SJ; Chaimowitz, NS; Mathews, J; Conrad, DH
The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity.
Mol Immunol
2011
Mus sp.
Gibb, DR; Saleem, SJ; Kang, DJ; Subler, MA; Conrad, DH
ADAM10 Overexpression Shifts Lympho- and Myelopoiesis by Dysregulating Site 2/Site 3 Cleavage Products of Notch.
J Immunol
186
4244-52
2011
Mus sp.
Durairajan, SS; Liu, LF; Lu, JH; Koo, I; Maruyama, K; Chung, SK; Huang, JD; Li, M
Stimulation of Non-Amyloidogenic Processing of Amyloid-? Protein Precursor by Cryptotanshinone Involves Activation and Translocation of ADAM10 and PKC-?
J Alzheimers Dis
2011
Homo sapiens, Mus musculus, Salvia miltiorrhiza
Esteve, P; Sandonģs, A; Cardozo, M; Malapeira, J; Ibańez, C; Crespo, I; Marcos, S; Gonzalez-Garcia, S; Toribio, ML; Arribas, J; Shimono, A; Guerrero, I; Bovolenta, P
SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.
Nat Neurosci
2011
Drosophila, Mus musculus
Endres, K; Fahrenholz, F
The Role of the Anti-Amyloidogenic Secretase ADAM10 in Shedding the APP-Like Proteins.
Curr Alzheimer Res
2011
Mus musculus
Glomski, K; Monette, S; Manova, K; De Strooper, B; Saftig, P; Blobel, CP
Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures.
Blood
118
1163-74
2011
Mus sp.
Schelter, F; Grandl, M; Seubert, B; Schaten, S; Hauser, S; Gerg, M; Boccaccio, C; Comoglio, P; Krüger, A
Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10.
Clin Exp Metastasis
2011
Mus musculus
Lee, SB; Doberstein, K; Baumgarten, P; Wieland, A; Ungerer, C; Bürger, C; Hardt, K; Boehncke, WH; Pfeilschifter, J; Mihic-Probst, D; Mittelbronn, M; Gutwein, P
PAX2 Regulates ADAM10 Expression and Mediates Anchorage-Independent Cell Growth of Melanoma Cells.
PLoS One
6
e22312
2011
Homo sapiens
Moss, ML; Powell, G; Miller, MA; Edwards, L; Qi, B; Sang, QX; De Strooper, B; Tesseur, I; Lichtenthaler, SF; Taverna, M; Zhong, JL; Dingwall, C; Ferdous, T; Schlomann, U; Zhou, P; Griffith, LG; Lauffenburger, DA; Petrovich, R; Bartsch, JW
ADAM9 inhibition increases membrane activity of ADAM10 and controls ?-secretase processing of amyloid precursor protein.
J Biol Chem
286
40443-51
2011
Escherichia coli, Homo sapiens, Mus musculus
Barsoum, IB; Hamilton, TK; Li, X; Cotechini, T; Miles, EA; Siemens, DR; Graham, CH
Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide.
Cancer Res
71
7433-41
2011
Mus sp.
Yoda, M; Kimura, T; Tohmonda, T; Uchikawa, S; Koba, T; Takito, J; Morioka, H; Matsumoto, M; Link, DC; Chiba, K; Okada, Y; Toyama, Y; Horiuchi, K
Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis.
Blood
118
6939-42
2011
Mus sp.
Sun, M; Zhou, T; Zhou, L; Chen, Q; Yu, Y; Yang, H; Zhong, K; Zhang, X; Xu, F; Cai, S; Yu, A; Zhang, H; Xiao, R; Xiao, D; Chui, D
Formononetin Protects Neurons Against Hypoxia-Induced Cytotoxicity Through Upregulation of ADAM10 and sA?PP?.
J Alzheimers Dis
28
795-808
2012
Radix
Wan, XZ; Li, B; Li, YC; Yang, XL; Zhang, W; Zhong, L; Tang, SJ
Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway.
J Neurosci
32
3910-6
2012
Mus musculus
Warren, KM; Reeves, TM; Phillips, LL
MT5-MMP, ADAM-10, and N-cadherin act in concert to facilitate synapse reorganization after traumatic brain injury.
J Neurotrauma
29
1922-40
2012
Rattus
Bekris, LM; Lutz, F; Li, G; Galasko, DR; Farlow, MR; Quinn, JF; Kaye, JA; Leverenz, JB; Tsuang, DW; Montine, TJ; Peskind, ER; Yu, CE
ADAM10 expression and promoter haplotype in Alzheimer's disease.
Neurobiol Aging
33
2229.e1-2229.e9
2012
Homo sapiens, Hippocampus
Pan, Y; Han, C; Wang, C; Hu, G; Luo, C; Gan, X; Zhang, F; Lu, Y; Ding, X
ADAM10 promotes pituitary adenoma cell migration by regulating cleavage of CD44 and L1.
J Mol Endocrinol
49
21-33
2012
Homo sapiens
Augustin, R; Endres, K; Reinhardt, S; Kuhn, PH; Lichtenthaler, SF; Hansen, J; Wurst, W; Trümbach, D
Computational identification and experimental validation of microRNAs binding to the Alzheimerrelated gene ADAM10.
BMC Med Genet
13
35
2012
Homo sapiens
Haining, EJ; Yang, J; Bailey, RL; Khan, K; Collier, R; Tsai, S; Watson, SP; Frampton, J; Garcia, P; Tomlinson, MG
The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.
J Biol Chem
287
39753-65
2012
Homo sapiens, Mus musculus
Liu, J; Zhou, CW; Wei, QL; Zhuang, JL; Lin, ZH; Zheng, JH
[Generation and characterization of the adult neuron-specific ADAM10 knock-out mice].
Yi Chuan
34
1570-6
2012
Hippocampus, Mus musculus, Mus sp.
Manzine, PR; de Franēa Bram, JM; Barham, EJ; Vale, Fde A; Selistre-de-Araśjo, HS; Cominetti, MR; Iost Pavarini, SC
ADAM10 as a Biomarker for Alzheimer's Disease: A Study with Brazilian Elderly.
Dement Geriatr Cogn Disord
35
58-66
2013
Homo sapiens
Cheng, C; Li, W; Zhang, Z; Yoshimura, S; Hao, Q; Zhang, C; Wang, Z
MicroRNA-144 is regulated by activator protein-1 (AP-1) and decreases expression of Alzheimer disease-related a disintegrin and metalloprotease 10 (ADAM10).
J Biol Chem
288
13748-61
2013
Primates, Homo sapiens
Manzine, PR; Barham, EJ; Vale, Fde A; Selistre-de-Araśjo, HS; Iost Pavarini, SC; Cominetti, MR
Correlation between mini-mental state examination and platelet ADAM10 expression in Alzheimer's disease.
J Alzheimers Dis
36
253-60
2013
Homo sapiens
Kono, M; Sugiura, K; Suganuma, M; Hayashi, M; Takama, H; Suzuki, T; Matsunaga, K; Tomita, Y; Akiyama, M
Whole-exome sequencing identifies ADAM10 mutations as a cause of reticulate acropigmentation of Kitamura, a clinical entity distinct from Dowling-Degos disease.
Hum Mol Genet
22
3524-33
2013
Homo sapiens
Miller, MA; Meyer, AS; Beste, MT; Lasisi, Z; Reddy, S; Jeng, KW; Chen, CH; Han, J; Isaacson, K; Griffith, LG; Lauffenburger, DA
ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling.
Proc Natl Acad Sci U S A
110
E2074-83
2013
Homo sapiens
Marcello, E; Saraceno, C; Musardo, S; Vara, H; de la Fuente, AG; Pelucchi, S; Di Marino, D; Borroni, B; Tramontano, A; Pérez-Otańo, I; Padovani, A; Giustetto, M; Gardoni, F; Di Luca, M
Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
J Clin Invest
123
2523-38
2013
insertion sequences, Homo sapiens
Prox, J; Bernreuther, C; Altmeppen, H; Grendel, J; Glatzel, M; D'Hooge, R; Stroobants, S; Ahmed, T; Balschun, D; Willem, M; Lammich, S; Isbrandt, D; Schweizer, M; Horré, K; De Strooper, B; Saftig, P
Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.
J Neurosci
33
12915-28, 12928a
2013
Mus musculus, Mus sp.
Zhang, SQ; Sawmiller, D; Li, S; Rezai-Zadeh, K; Hou, H; Zhou, S; Shytle, D; Giunta, B; Fernandez, F; Mori, T; Tan, J
Octyl Gallate Markedly Promotes Anti-Amyloidogenic Processing of APP through Estrogen Receptor-Mediated ADAM10 Activation.
PLoS One
8
e71913
2013
Homo sapiens, Mus musculus, Mus sp.
Musardo, S; Marcello, E; Gardoni, F; Di Luca, M
ADAM10 in Synaptic Physiology and Pathology.
Neurodegener Dis
2013
insertion sequences
Suh, J; Choi, SH; Romano, DM; Gannon, MA; Lesinski, AN; Kim, DY; Tanzi, RE
ADAM10 Missense Mutations Potentiate ?-Amyloid Accumulation by Impairing Prodomain Chaperone Function.
Neuron
2013
Homo sapiens, Mus musculus, Mus sp.
Zhao, R; Wang, A; Hall, KC; Otero, M; Weskamp, G; Zhao, B; Hill, D; Goldring, MB; Glomski, K; Blobel, CP
Lack of ADAM10 in endothelial cells affects osteoclasts at the chondro-osseus junction.
J Orthop Res
32
224-30
2014
Mus sp.
Padro, CJ; Shawler, TM; Gormley, MG; Sanders, VM
Adrenergic regulation of IgE involves modulation of CD23 and ADAM10 expression on exosomes.
J Immunol
191
5383-97
2013
Electron, Mus musculus
Reinhardt, S; Schuck, F; Grösgen, S; Riemenschneider, M; Hartmann, T; Postina, R; Grimm, M; Endres, K
Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease.
FASEB J
28
978-97
2014
Homo sapiens, Mus sp., Metazoa, Mus musculus
Weber, S; Wetzel, S; Prox, J; Lehmann, T; Schneppenheim, J; Donners, M; Saftig, P
Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10).
Biochem Biophys Res Commun
442
234-41
2013
Mus sp.
Yan, X; Lin, J; Talabattula, VA; Mußmann, C; Yang, F; Wree, A; Rolfs, A; Luo, J
ADAM10 negatively regulates neuronal differentiation during spinal cord development.
PLoS One
9
e84617
2014
Gallus gallus
Wojtalewicz, N; Sadeqzadeh, E; Weiß, JV; Tehrani, MM; Klein-Scory, S; Hahn, S; Schmiegel, W; Warnken, U; Schnölzer, M; de Bock, CE; Thorne, RF; Schwarte-Waldhoff, I
A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding.
PLoS One
9
e90461
2014
Homo sapiens
Wang, JY; Darbinyan, A; White, MK; Darbinian, N; Reiss, K; Amini, S
Involvement of IRS-1 Interaction with ADAM10 in the Regulation of Neurite Extension.
J Cell Physiol
2013
Human immunodeficiency virus 1, clinical samples
Lee, HR; Shin, HK; Park, SY; Kim, HY; Lee, WS; Rhim, BY; Hong, KW; Kim, CD
Cilostazol suppresses ?-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-?.
J Neurosci Res
92
1581-90
2014
Homo sapiens
Feldinger, K; Generali, D; Kramer-Marek, G; Gijsen, M; Ng, TB; Wong, JH; Strina, C; Cappelletti, M; Andreis, D; Li, JL; Bridges, E; Turley, H; Leek, R; Roxanis, I; Capala, J; Murphy, G; Harris, AL; Kong, A
ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer.
Oncotarget
5
6633-46
2014
Homo sapiens, Mus sp.
Ebsen, H; Lettau, M; Kabelitz, D; Janssen, O
Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).
PLoS One
9
e102899
2014
Homo sapiens
Gangemi, R; Amaro, A; Gino, A; Barisione, G; Fabbi, M; Pfeffer, U; Brizzolara, A; Queirolo, P; Salvi, S; Boccardo, S; Gualco, M; Spagnolo, F; Jager, MJ; Mosci, C; Rossello, A; Ferrini, S
ADAM10 correlates with uveal melanoma metastasis and promotes in vitro invasion.
Pigment Cell Melanoma Res
27
1138-48
2014
Homo sapiens
Zhang, W; Liu, S; Liu, K; Ji, B; Wang, Y; Liu, Y
Knockout of ADAM10 enhances sorafenib antitumor activity of hepatocellular carcinoma in vitro and in vivo.
Oncol Rep
32
1913-22
2014
Mus musculus
Ma, Z; Li, Q; Zhang, Z; Zheng, Y
A Disintegrin and Metalloprotease 10 in neuronal maturation and gliogenesis during cortex development.
Neural Regen Res
8
24-30
2013
Mus musculus, Mus sp.
Liu, S; Zhang, W; Liu, K; Ji, B; Wang, G
Silencing ADAM10 inhibits the in vitro and in vivo growth of hepatocellular carcinoma cancer cells.
Mol Med Rep
11
597-602
2015
Homo sapiens
Deng, W; Cho, S; Su, PC; Berger, BW; Li, R
Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10.
Proc Natl Acad Sci U S A
111
15987-92
2014
Escherichia coli
Saraceno, C; Marcello, E; Di Marino, D; Borroni, B; Claeysen, S; Perroy, J; Padovani, A; Tramontano, A; Gardoni, F; Di Luca, M
SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation.
Cell Death Dis
5
e1547
2014
insertion sequences
Zeng, F; Shen, C; Liu, YH; Li, J; Zhu, J; Wang, YR; Yan, JC; Gao, CY; Zhou, HD; Deng, J; Wang, YJ
Genetic Association Between APP, ADAM10 Gene Polymorphism, and Sporadic Alzheimer's Disease in the Chinese Population.
Neurotox Res
27
284-91
2015
Homo sapiens
Chang, YC; Jan, CI; Peng, CY; Lai, YC; Hu, FW; Yu, CC
Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas.
Oncotarget
6
24002-16
2015
Mus sp.
Li, D; Xiao, Z; Wang, G; Song, X
Knockdown of ADAM10 inhibits migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis.
Mol Med Rep
12
5517-23
2015
Homo sapiens, Mus musculus, Mus sp.
Mullooly, M; McGowan, PM; Kennedy, SA; Madden, SF; Crown, J; O' Donovan, N; Duffy, MJ
ADAM10: a new player in breast cancer progression?
Br J Cancer
113
945-51
2015
Homo sapiens
Post, S; Rozeveld, D; Jonker, MR; Bischoff, R; van Oosterhout, AJ; Heijink, IH
ADAM10 mediates the house dust mite-induced release of chemokine ligand CCL20 by airway epithelium.
Allergy
70
1545-52
2015
Homo sapiens, Mus sp.
Woods, N; Trevino, J; Coppola, D; Chellappan, S; Yang, S; Padmanabhan, J
Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and ?-catenin signaling.
Oncotarget
6
35931-48
2015
Homo sapiens
Mizuno, S; Yoda, M; Shimoda, M; Tohmonda, T; Okada, Y; Toyama, Y; Takeda, S; Nakamura, M; Matsumoto, M; Horiuchi, K
A Disintegrin and Metalloprotease 10 (ADAM10) Is Indispensable for Maintenance of the Muscle Satellite Cell Pool.
J Biol Chem
290
28456-64
2015
Mus sp.
Noy, PJ; Yang, J; Reyat, JS; Matthews, AL; Charlton, AE; Furmston, J; Rogers, DA; Rainger, GE; Tomlinson, MG
TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS.
J Biol Chem
291
3145-57
2016
Homo sapiens, Mammalia
Schuck, F; Wolf, D; Fellgiebel, A; Endres, K
Increase of ?-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging.
J Alzheimers Dis
50
817-26
2016
Homo sapiens
Tao, H; Zhao, J; Zhou, X; Ma, Z; Chen, Y; Sun, F; Cui, L; Zhou, H; Cai, Y; Chen, Y; Zhao, S; Yao, L; Zhao, B; Li, K
Promoter Variants of the ADAM10 Gene and Their Roles in Temporal Lobe Epilepsy.
Front Neurol
7
108
2016
Homo sapiens
Marchesi, N; Amadio, M; Colombrita, C; Govoni, S; Ratti, A; Pascale, A
PKC Activation Counteracts ADAM10 Deficit in HuD-Silenced Neuroblastoma Cells.
J Alzheimers Dis
54
535-47
2016
Homo sapiens
Atapattu, L; Saha, N; Chheang, C; Eissman, MF; Xu, K; Vail, ME; Hii, L; Llerena, C; Liu, Z; Horvay, K; Abud, HE; Kusebauch, U; Moritz, RL; Ding, BS; Cao, Z; Rafii, S; Ernst, M; Scott, AM; Nikolov, DB; Lackmann, M; Janes, PW
An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.
J Exp Med
213
1741-57
2016
Homo sapiens, Mus musculus
Shackleton, B; Crawford, F; Bachmeier, C
Inhibition of ADAM10 promotes the clearance of A? across the BBB by reducing LRP1 ectodomain shedding.
Fluids Barriers CNS
13
14
2016
Mus musculus, Mus sp., Metazoa
Caltabiano, R; Puzzo, L; Barresi, V; Ieni, A; Loreto, C; Musumeci, G; Castrogiovanni, P; Ragusa, M; Foti, P; Russo, A; Longo, A; Reibaldi, M
ADAM 10 expression in primary uveal melanoma as prognostic factor for risk of metastasis.
Pathol Res Pract
2016
Homo sapiens
Seipold, L; Damme, M; Prox, J; Rabe, B; Kasparek, P; Sedlacek, R; Altmeppen, H; Willem, M; Boland, B; Glatzel, M; Saftig, P
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.
Biochim Biophys Acta
1864
217-230
2017
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Mus sp.
Wang, XL; Liu, Q; Chen, GJ; Li, ML; Ding, YH
Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10.
Biochem Biophys Res Commun
482
928-934
2017
Mus sp., Hippocampus
Madoux, F; Dreymuller, D; Pettiloud, JP; Santos, R; Becker-Pauly, C; Ludwig, A; Fields, GB; Bannister, T; Spicer, TP; Cudic, M; Scampavia, LD; Minond, D
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate.
Sci Rep
6
11
2016
collection
Hu, XT; Zhu, BL; Zhao, LG; Wang, JW; Liu, L; Lai, YJ; He, L; Deng, XJ; Chen, GJ
Histone deacetylase inhibitor apicidin increases expression of the ?-secretase ADAM10 through transcription factor USF1-mediated mechanisms.
FASEB J
31
1482-1493
2017
Anser
Shackleton, B; Crawford, F; Bachmeier, C
Apolipoprotein E-mediated Modulation of ADAM10 in Alzheimer's Disease.
Curr Alzheimer Res
14
578-585
2017
Homo sapiens
Li, J; Ouyang, Q; Chen, CW; Chen, QB; Li, XN; Xiang, ZH; Yuan, HB
Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury-Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells.
Pain Med
18
1752-1766
2017
Rattus
Jiao, T; Yao, Y; Zhang, B; Hao, DC; Sun, QF; Li, JB; Yuan, C; Jing, B; Wang, YP; Wang, HY
Role of MicroRNA-103a Targeting ADAM10 in Abdominal Aortic Aneurysm.
Biomed Res Int
2017
9645874
2017
Mus musculus
Matthews, AL; Szyroka, J; Collier, R; Noy, PJ; Tomlinson, MG
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.
Biochem Soc Trans
45
719-730
2017
Mammalia, prion, Staphylococcus aureus
Wetzel, S; Seipold, L; Saftig, P
The metalloproteinase ADAM10: A useful therapeutic target?
Biochim Biophys Acta
2017
Homo sapiens
Ding, C; Zhang, Q; Chen, Y; Zhang, X; Wu, P; Zhang, Z
Overexpression of A disintegrin and metalloprotease 10 promotes tumor proliferation, migration and poor prognosis in hypopharyngeal squamous cell carcinoma.
Oncol Rep
38
866-874
2017
Homo sapiens
Xu, LF; Luo, JP; Li, HJ; Lu, Q; Zhang, QN; Yao, Y; Yao, RS; Xu, KL; Li, ZY
[Effect of Interfering the ADAM10 by Lentivirul Vector-Mediated shRNA on Multiple Myeloma MM.1S Cell Proliferation].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
25
1074-1079
2017
Lentivirus
Marcello, E; Borroni, B; Pelucchi, S; Gardoni, F; Di Luca, M
ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer's disease.
Expert Opin Ther Targets
21
1017-1026
2017
Areas
Farber, G; Hurtado, R; Loh, S; Monette, S; Mtui, J; Kopan, R; Quaggin, S; Meyer-Schwesinger, C; Herzlinger, D; Scott, RP; Blobel, CP
Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling.
Angiogenesis
21
335-347
2018
Mus sp.
Mizuno, S; Yoda, M; Shimoda, M; Chiba, K; Nakamura, M; Horiuchi, K
Inhibition of ADAM10 in satellite cells accelerates muscle regeneration following muscle injury.
J Orthop Res
2018
Mus sp.
Seipold, L; Altmeppen, H; Koudelka, T; Tholey, A; Kasparek, P; Sedlacek, R; Schweizer, M; Bär, J; Mikhaylova, M; Glatzel, M; Saftig, P
In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15.
Cell Mol Life Sci
2018
Mus musculus, Mus sp., prion
Li, X; Xie, L; He, B; Huang, W
[Improvement and the mechanism of cardiac function by knockdown of ADAM10 in adriamycin-induced cardiomyopathy rats].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
34
41-46
2018
Rattus
Guo, J; Du, J; Fei, D; Xing, J; Liu, J; Lu, H
miR?152 inhibits rheumatoid arthritis synovial fibroblast proliferation and induces apoptosis by targeting ADAM10.
Int J Mol Med
42
643-650
2018
Homo sapiens
Matthews, AL; Koo, CZ; Szyroka, J; Harrison, N; Kanhere, A; Tomlinson, MG
Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10.
Front Immunol
9
1451
2018
Mus sp.
Mahasenan, KV; Ding, D; Gao, M; Nguyen, TT; Suckow, MA; Schroeder, VA; Wolter, WR; Chang, M; Mobashery, S
In Search of Selectivity in Inhibition of ADAM10.
ACS Med Chem Lett
9
708-713
2018
Homo sapiens, Mus sp.
Sogorb-Esteve, A; Garcķa-Ayllón, MS; Gobom, J; Alom, J; Zetterberg, H; Blennow, K; Sįez-Valero, J
Levels of ADAM10 are reduced in Alzheimer's disease CSF.
J Neuroinflammation
15
213
2018
Homo sapiens
Hou, L; Du, Y; Zhao, C; Wu, Y
PAX2 may induce ADAM10 expression in renal tubular epithelial cells and contribute to epithelial-to-mesenchymal transition.
Int Urol Nephrol
50
1729-1741
2018
Homo sapiens, Rattus
Liu, C; Kong, X; Wu, X; Wang, X; Guan, H; Wang, H; Wang, L; Jin, X; Yuan, H
Alleviation of A disintegrin and metalloprotease 10 (ADAM10) on thromboangiitis obliterans involves the HMGB1/RAGE/ NF-?B pathway.
Biochem Biophys Res Commun
2018
Rattus, Rattus norvegicus
Shiu, JS; Hsieh, MJ; Chiou, HL; Wang, HL; Yeh, CB; Yang, SF; Chou, YE
Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics.
Int J Med Sci
15
1334-1340
2018
Homo sapiens
Tsang, JYS; Lee, MA; Chan, TH; Li, J; Ni, YB; Shao, Y; Chan, SK; Cheungc, SY; Lau, KF; Tse, GMK
Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer.
EBioMedicine
38
89-99
2018
Homo sapiens
Huang, WH; Chen, W; Jiang, LY; Yang, YX; Yao, LF; Li, KS
Influence of ADAM10 Polymorphisms on Plasma Level of Soluble Receptor for Advanced Glycation End Products and The Association With Alzheimer's Disease Risk.
Front Genet
9
540
2018
Homo sapiens
Wang, YM; Zheng, YF; Yang, SY; Yang, ZM; Zhang, LN; He, YQ; Gong, XH; Liu, D; Finnell, RH; Qiu, ZL; Du, YS; Wang, HY
MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitors.
Cell Death Differ
2018
Homo sapiens, Mus musculus
Sépult, C; Bellefroid, M; Rocks, N; Donati, K; Gérard, C; Gilles, C; Ludwig, A; Duysinx, B; Noėl, A; Cataldo, D
ADAM10 mediates malignant pleural mesothelioma invasiveness.
Oncogene
2019
Homo sapiens, Mus musculus
Brummer, T; Müller, SA; Pan-Montojo, F; Yoshida, F; Fellgiebel, A; Tomita, T; Endres, K; Lichtenthaler, SF
NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease.
EMBO Mol Med
11
2019
Homo sapiens
Vezzoli, E; Caron, I; Talpo, F; Besusso, D; Conforti, P; Battaglia, E; Sogne, E; Falqui, A; Petricca, L; Verani, M; Martufi, P; Caricasole, A; Bresciani, A; Cecchetti, O; Rivetti di Val Cervo, P; Sancini, G; Riess, O; Nguyen, H; Seipold, L; Saftig, P; Biella, G; Cattaneo, E; Zuccato, C
Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease.
J Clin Invest
129
2390-2403
2019
Homo sapiens, Mus musculus, Mus sp.
Gunner, G; Cheadle, L; Johnson, KM; Ayata, P; Badimon, A; Mondo, E; Nagy, MA; Liu, L; Bemiller, SM; Kim, KW; Lira, SA; Lamb, BT; Tapper, AR; Ransohoff, RM; Greenberg, ME; Schaefer, A; Schafer, DP
Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling.
Nat Neurosci
22
1075-1088
2019
Mus sp.
Ding, Y; Bui, MM; Wang, Q; Sun, X; Zhang, M; Niu, X; Tian, W
ADAM10 Is a Potential Novel Prognostic Biomarker for Sacral Chordoma.
Ann Clin Lab Sci
49
309-316
2019
Homo sapiens
Etemad-Moghadam, S; Alaeddini, M
Upregulation of ADAM10 in oral squamous cell carcinoma and its correlation with EGFR, neoangiogenesis and clinicopathologic factors.
J Craniomaxillofac Surg
2019
Homo sapiens
Koo, CZ; Harrison, N; Noy, PJ; Szyroka, J; Matthews, AL; Hsia, HE; Müller, SA; Tüshaus, J; Goulding, J; Willis, K; Apicella, C; Cragoe, B; Davis, E; Keles, M; Malinova, A; McFarlane, TA; Morrison, PR; Nguyen, HTH; Sykes, MC; Ahmed, H; Di Maio, A; Seipold, L; Saftig, P; Cull, E; Pliotas, C; Rubinstein, E; Poulter, NS; Briddon, SJ; Holliday, ND; Lichtenthaler, SF; Tomlinson, MG
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
J Biol Chem
2020
Homo sapiens, Mus musculus, Mus sp.
Yuan, Q; Yu, H; Chen, J; Song, X; Sun, L
ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/?-catenin signaling pathway and is regulated by miR-122-5p.
Cancer Cell Int
20
99
2020
Mus musculus
Seifert, A; Düsterhöft, S; Wozniak, J; Koo, CZ; Tomlinson, MG; Nuti, E; Rossello, A; Cuffaro, D; Yildiz, D; Ludwig, A
The metalloproteinase ADAM10 requires its activity to sustain surface expression.
Cell Mol Life Sci
2020
Mus sp.
Chen, Y; Wang, Z; Li, Q; Yu, L; Zhu, Y; Wang, J; Sun, S
oxLDL promotes podocyte migration by regulating CXCL16, ADAM10 and ACTN4.
Mol Med Rep
22
1976-1984
2020
Homo sapiens
Li, B; Zhu, C; Dong, L; Qin, J; Xiang, W; Davidson, AJ; Feng, S; Wang, Y; Shen, X; Weng, C; Wang, C; Zhu, T; Teng, L; Wang, J; Englert, C; Chen, J; Jiang, H
ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling.
J Pathol
e5517
2020
Homo sapiens, Mus sp.
Cheng, Y; Lin, L; Li, X; Lu, A; Hou, C; Wu, Q; Hu, X; Zhou, Z; Chen, Z; Tang, F
ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPc.
Cancer Cell Int
21
32
2021
Homo sapiens
Pan, B; Huo, T; Cao, M; Jing, L; Luo, X; Qu, Z; Feng, H; Yuan, F; Guo, K
ADAM10 promotes the proliferation of ligamentum flavum cells by activating the PI3K/AKT pathway.
Int J Mol Med
47
688-698
2021
Stenosis
Wang, H; Muthu Karuppan, MK; Nair, M; Lakshmana, MK
Autophagy-Dependent Increased ADAM10 Mature Protein Induced by TFEB Overexpression Is Mediated Through PPAR?.
Mol Neurobiol
58
2269-2283
2021
Hippocampus
Oliveira Monteiro, MPA; Salheb Oliveira, DSM; Manzine, PR; Crispim Nascimento, CM; Dos Santos Orlandi, AA; de Oliveira Gomes, GA; Dos Santos Orlandi, F; Zazzetta, MS; Pott-Junior, H; Cominetti, MR
ADAM10 plasma levels predict worsening in cognition of older adults: a 3-year follow-up study.
Alzheimers Res Ther
13
18
2021
Homo sapiens
Mueller, AC; Piper, M; Goodspeed, A; Bhuvane, S; Williams, JS; Bhatia, S; Phan, AV; Van Court, B; Zolman, KL; Peńa, B; Oweida, AJ; Zakem, S; Meguid, C; Knitz, MW; Darragh, L; Bickett, TE; Gadwa, J; Mestroni, L; Taylor, MRG; Jordan, KR; Dempsey, P; Lucia, MS; McCarter, MD; Chiaro, MD; Messersmith, WA; Schulick, RD; Goodman, KA; Gough, MJ; Greene, CS; Costello, JC; Neto, AG; Lagares, D; Hansen, KC; Van Bokhoven, A; Karam, SD
Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer.
Cancer Res
81
3255-3269
2021
Mus musculus
Fu, Q; Tang, Y; Peng, J; He, J; Zou, Q; Yan, S; Zheng, Z; Pan, H
miR-520d suppresses rapid pacing-induced apoptosis of atrial myocytes through mediation of ADAM10.
J Mol Histol
52
207-217
2021
Mus musculus
Cozzolino, F; Vezzoli, E; Cheroni, C; Besusso, D; Conforti, P; Valenza, M; Iacobucci, I; Monaco, V; Birolini, G; Bombaci, M; Falqui, A; Saftig, P; Rossi, RL; Monti, M; Cattaneo, E; Zuccato, C
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.
Hum Mol Genet
2021
Mus sp.
Pereira Vatanabe, I; Peron, R; Mantellatto Grigoli, M; Pelucchi, S; De Cesare, G; Magalhćes, T; Manzine, PR; Figueredo Balthazar, ML; Di Luca, M; Marcello, E; Cominetti, MR
ADAM10 Plasma and CSF Levels Are Increased in Mild Alzheimer's Disease.
Int J Mol Sci
22
2021
Homo sapiens
Alakus, H; Kaya, M; Ozer, H; Egilmez, HR; Karadayi, K
ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort.
Pak J Med Sci
37
543-549
0
Homo sapiens
Persad, A; Pham, N; Moien-Afshari, F; Gormley, W; Yan, S; Mannix, R; Taghibiglou, C
Plasma PrPC and ADAM-10 as novel biomarkers for traumatic brain injury and concussion: a pilot study.
Brain Inj
35
734-741
2021
Homo sapiens, prion
Zhong, M; Kou, H; Zhao, P; Zheng, W; Xu, H; Zhang, X; Lan, W; Guo, C; Wang, T; Guo, F; Wang, Z; Gao, H
Nasal Delivery of D-Penicillamine Hydrogel Upregulates a Disintegrin and Metalloprotease 10 Expression via Melatonin Receptor 1 in Alzheimer's Disease Models.
Front Aging Neurosci
13
660249
2021
Mus sp.
Otoyama, Y; Arai, J; Goto, K; Nozawa, H; Nakagawa, R; Muroyama, R; Sugiura, I; Nakajima, Y; Kajiwara, A; Tojo, M; Ichikawa, Y; Uozumi, S; Shimozuma, Y; Uchikoshi, M; Sakaki, M; Kato, N; Yoshida, H
Retinoids Decrease Soluble MICA Concentration by Inhibiting the Enzymatic Activity of ADAM9 and ADAM10.
Anticancer Res
41
2307-2320
2021
Homo sapiens
Byun, JK; Kim, KH; Rha, SW; Park, Y; Cha, JA; Choi, SY; Choi, BG; Choi, CU
ADAM10 inhibits the interaction between IL-17 and HMGB1 in Buerger's disease.
Eur Rev Med Pharmacol Sci
25
4051-4063
2021
Homo sapiens
Li, X; Pan, F; He, B; Fang, C
Inhibition of ADAM10 ameliorates doxorubicin-induced cardiac remodeling by suppressing N-cadherin cleavage.
Open Life Sci
16
856-866
2021
Lentivirus
Diener, N; Fontaine, JF; Klein, M; Hieronymus, T; Wanke, F; Kurschus, FC; Ludwig, A; Ware, C; Saftig, P; Bopp, T; Clausen, BE; Backer, RA
Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone.
Proc Natl Acad Sci U S A
118
2021
Mus sp.
Romero, Y; Wise, R; Zolkiewska, A
Proteolytic processing of PD-L1 by ADAM proteases in breast cancer cells.
Cancer Immunol Immunother
69
43-55
2020
Homo sapiens
Duhachek-Muggy, S; Zolkiewska, A
ADAM12-L is a direct target of the miR-29 and miR-200 families in breast cancer.
BMC Cancer
15
93
2015
Homo sapiens
Londino, JD; Gulick, D; Isenberg, JS; Mallampalli, RK
Cleavage of Signal Regulatory Protein ? (SIRP?) Enhances Inflammatory Signaling.
J Biol Chem
290
31113-25
2015
Homo sapiens, plasmids
Cardellini, M; Menghini, R; Martelli, E; Casagrande, V; Marino, A; Rizza, S; Porzio, O; Mauriello, A; Solini, A; Ippoliti, A; Lauro, R; Folli, F; Federici, M
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
Diabetes
58
2396-401
2009
Homo sapiens
Hinkle, CL; Mohan, MJ; Lin, P; Yeung, N; Rasmussen, F; Milla, ME; Moss, ML
Multiple metalloproteinases process protransforming growth factor-alpha (proTGF-alpha).
Biochemistry
42
2127-36
2003
Rattus
van der Voort, R; van Lieshout, AW; Toonen, LW; Slƶetjes, AW; van den Berg, WB; Figdor, CG; Radstake, TR; Adema, GJ
Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints.
Arthritis Rheum
52
1381-91
2005
Homo sapiens
Naus, S; ReipschlƤger, S; Wildeboer, D; Lichtenthaler, SF; Mitterreiter, S; Guan, Z; Moss, ML; Bartsch, JW
Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8.
Biol Chem
387
337-46
2006
Escherichia coli, Homo sapiens
Maretzky, T; Scholz, F; Kƶten, B; Proksch, E; Saftig, P; Reiss, K
ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis.
J Invest Dermatol
128
1737-46
2008
Homo sapiens, Areas
Christian, LM
The ADAM family: Insights into Notch proteolysis.
Fly (Austin)
6
30-4
0
Diptera, Mus musculus, Mammalia
Joshi, YB; Chu, J; Praticņ, D
Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.
J Alzheimers Dis
31
167-76
2012
Metazoa, Mus sp.
Suzuki, K; Hayashi, Y; Nakahara, S; Kumazaki, H; Prox, J; Horiuchi, K; Zeng, M; Tanimura, S; Nishiyama, Y; Osawa, S; Sehara-Fujisawa, A; Saftig, P; Yokoshima, S; Fukuyama, T; Matsuki, N; Koyama, R; Tomita, T; Iwatsubo, T
Activity-dependent proteolytic cleavage of neuroligin-1.
Neuron
76
410-22
2012
Rattus
Dreymueller, D; Uhlig, S; Ludwig, A
ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets.
Am J Physiol Lung Cell Mol Physiol
308
L325-L343
2015
Staphylococcus aureus
Carboni, L; Pischedda, F; Piccoli, G; Lauria, M; Musazzi, L; Popoli, M; Mathé, AA; Domenici, E
Depression-Associated Gene Negr1-Fgfr2 Pathway Is Altered by Antidepressant Treatment.
Cells
9
2020
Mus musculus, Rattus, Hippocampus
Sachs, M; Wetzel, S; Reichelt, J; Sachs, W; Schebsdat, L; Zielinski, S; Seipold, L; Heintz, L; Müller, SA; Kretz, O; Lindenmeyer, M; Wiech, T; Huber, TB; Lüllmann-Rauch, R; Lichtenthaler, SF; Saftig, P; Meyer-Schwesinger, C
ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage.
J Am Soc Nephrol
32
1389-1408
2021
Homo sapiens, Mus musculus, Mus sp., Electron
Li, Y; Feng, C; Wei, X; Zhang, J; Zan, R; Zheng, G; Yang, X; Zhai, J
Activation of protease-activated receptor-2 disrupts vaginal epithelial barrier function.
Cell Biol Int
38
1247-51
2014
Homo sapiens
Dewitz, C; Möller-Hackbarth, K; Schweigert, O; Reiss, K; Chalaris, A; Scheller, J; Rose-John, S
T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.
FEBS J
281
157-74
2014
Mus musculus
Zingoni, A; Cecere, F; Vulpis, E; Fionda, C; Molfetta, R; Soriani, A; Petrucci, MT; Ricciardi, MR; Fuerst, D; Amendola, MG; Mytilineos, J; Cerboni, C; Paolini, R; Cippitelli, M; Santoni, A
Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.
J Immunol
195
736-48
2015
Homo sapiens
Lownik, JC; Luker, AJ; Damle, SR; Cooley, LF; El Sayed, R; Hutloff, A; Pitzalis, C; Martin, RK; El Shikh, MEM; Conrad, DH
ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.
J Immunol
199
2305-2315
2017
Homo sapiens
Venkatesh, HS; Tam, LT; Woo, PJ; Lennon, J; Nagaraja, S; Gillespie, SM; Ni, J; Duveau, DY; Morris, PJ; Zhao, JJ; Thomas, CJ; Monje, M
Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma.
Nature
549
533-537
2017
Homo sapiens, Mus sp.
Lagares, D; Ghassemi-Kakroodi, P; Tremblay, C; Santos, A; Probst, CK; Franklin, A; Santos, DM; Grasberger, P; Ahluwalia, N; Montesi, SB; Shea, BS; Black, KE; Knipe, R; Blati, M; Baron, M; Wu, B; Fahmi, H; Gandhi, R; Pardo, A; Selman, M; Wu, J; Pelletier, JP; Martel-Pelletier, J; Tager, AM; Kapoor, M
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis.
Nat Med
23
1405-1415
2017
Mus sp., Homo sapiens, Mus musculus
Defourny, J; Peuckert, C; Kullander, K; Malgrange, B
EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions.
iScience
11
246-257
2019
Mus sp.
He, W; Hu, J; Xia, Y; Yan, R
?-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) Regulates Notch Signaling by Controlling the Cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) Proteins.
J Biol Chem
289
20630-20637
2014
Mus sp.
Hikita, A; Yana, I; Wakeyama, H; Nakamura, M; Kadono, Y; Oshima, Y; Nakamura, K; Seiki, M; Tanaka, S
Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand.
J Biol Chem
281
36846-55
2006
Mus sp.
Yunusova, NV; Patysheva, MR; Molchanov, SV; Zambalova, EA; Grigor'eva, AE; Kolomiets, LA; Ochirov, MO; Tamkovich, SN; Kondakova, IV
Metalloproteinases at the surface of small extrcellular vesicles in advanced ovarian cancer: Relationships with ascites volume and peritoneal canceromatosis index.
Clin Chim Acta
494
116-122
2019
Homo sapiens
Zhang, Y; Yin, F; Liu, J; Liu, Z; Guo, L; Xia, Z; Zidichouski, J
Geniposide attenuates insulin-deficiency-induced acceleration of ?-amyloidosis in an APP/PS1 transgenic model of Alzheimer's disease.
Neurochem Int
89
7-16
2015
Mus sp.
Holback, S; Adlerz, L; Gatsinzi, T; Jacobsen, KT; Iverfeldt, K
PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid.
Biochem Biophys Res Commun
365
298-303
2008
Homo sapiens
Gutwein, P; Abdel-Bakky, MS; Doberstein, K; Schramme, A; Beckmann, J; Schaefer, L; Amann, K; Doller, A; KƤmpfer-Kolb, N; Abdel-Aziz, AA; El Sayed, ES; Pfeilschifter, J
CXCL16 and oxLDL are induced in the onset of diabetic nephropathy.
J Cell Mol Med
2009
Homo sapiens, Mus sp., Candida dubliniensis
Yang, WS; Yu, H; Kim, JJ; Lee, MJ; Park, SK
Vitamin D-induced ectodomain shedding of TNF receptor 1 as a nongenomic action: D3 vs D2 derivatives.
J Steroid Biochem Mol Biol
155
18-25
2016
Homo sapiens
Metz, VV; Kojro, E; Rat, D; Postina, R
Induction of RAGE Shedding by Activation of G Protein-Coupled Receptors.
PLoS One
7
e41823
2012
Mus musculus, Mus sp.
He, T; Santhanam, AV; Lu, T; d'Uscio, LV; Katusic, ZS
Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-? in cerebral microvessels.
J Cereb Blood Flow Metab
2015
Homo sapiens, Mus sp.
Gatta, LB; Vitali, M; Verardi, R; Arosio, P; Finazzi, D
Inhibition of heme synthesis alters Amyloid Precursor Protein processing.
J Neural Transm
116
79-88
2009
Homo sapiens
Jarriault, S; Le Bail, O; Hirsinger, E; PourquiƩ, O; Logeat, F; Strong, CF; Brou, C; Seidah, NG; Isra l, A
Delta-1 activation of notch-1 signaling results in HES-1 transactivation.
Mol Cell Biol
18
7423-31
1998
Drosophila
Murai, T; Miyazaki, Y; Nishinakamura, H; Sugahara, KN; Miyauchi, T; Sako, Y; Yanagida, T; Miyasaka, M
Engagement of CD44 promotes Rac activation and CD44 cleavage during tumor cell migration.
J Biol Chem
279
4541-50
2004
Areas
Zheng, Y; Saftig, P; Hartmann, D; Blobel, C
Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17).
J Biol Chem
279
42898-906
2004
Mus musculus
Kojro, E; Fahrenholz, F
The non-amyloidogenic pathway: structure and function of alpha-secretases.
Subcell Biochem
38
105-27
2005
Mus musculus
Higashiyama, S; Nanba, D
ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk.
Biochim Biophys Acta
1751
110-7
2005
Mus musculus
Maretzky, T; Schulte, M; Ludwig, A; Rose-John, S; Blobel, C; Hartmann, D; Altevogt, P; Saftig, P; Reiss, K
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth.
Mol Cell Biol
25
9040-53
2005
Mus musculus
Erin, N; Zhao, W; Bylander, J; Chase, G; Clawson, G
Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells.
Breast Cancer Res Treat
99
351-64
2006
Mus musculus, Mus sp., Metazoa
Yang, P; Baker, KA; Hagg, T
The ADAMs family: coordinators of nervous system development, plasticity and repair.
Prog Neurobiol
79
73-94
2006
Mus musculus
Mochizuki, S; Okada, Y
ADAMs in cancer cell proliferation and progression.
Cancer Sci
98
621-8
2007
Homo sapiens
Fahrenholz, F; Tippmann, F; Endres, K
Retinoids as a perspective in treatment of Alzheimer's disease.
Neurodegener Dis
7
190-2
2010
Homo sapiens, Mus musculus
Bender, M; Hofmann, S; Stegner, D; Chalaris, A; Bösl, M; Braun, A; Scheller, J; Rose-John, S; Nieswandt, B
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.
Blood
116
3347-55
2010
Mus sp.
Hashizume, M; Higuchi, Y; Uchiyama, Y; Mihara, M
IL-6 plays an essential role in neutrophilia under inflammation.
Cytokine
54
92-9
2011
Platyrrhini, Homo sapiens
Wang, HX; Li, Q; Sharma, C; Knoblich, K; Hemler, ME
Tetraspanin protein contributions to cancer.
Biochem Soc Trans
39
547-52
2011
Homo sapiens
Yamamoto, J; Maeno, K; Takada, T; Kakutani, K; Yurube, T; Zhang, Z; Hirata, H; Kurakawa, T; Sakai, D; Mochida, J; Doita, M; Kurosaka, M; Nishida, K
Fas ligand plays an important role for the production of pro-inflammatory cytokines in intervertebral disc nucleus pulposus cells.
J Orthop Res
31
608-15
2013
Homo sapiens
van Roeyen, CR; Zok, S; Pruessmeyer, J; Boor, P; Nagayama, Y; Fleckenstein, S; Cohen, CD; Eitner, F; Gröne, HJ; Ostendorf, T; Ludwig, A; Floege, J
Growth arrest-specific protein 1 is a novel endogenous inhibitor of glomerular cell activation and proliferation.
Kidney Int
83
251-63
2013
Mus musculus, Rattus
Freese, C; Reinhardt, S; Hefner, G; Unger, RE; Kirkpatrick, CJ; Endres, K
A novel blood-brain barrier co-culture system for drug targeting of Alzheimer's disease: establishment by using acitretin as a model drug.
PLoS One
9
e91003
2014
Mus sp., Homo sapiens, Sus scrofa
Garbers, C; Monhasery, N; Aparicio-Siegmund, S; Lokau, J; Baran, P; Nowell, MA; Jones, SA; Rose-John, S; Scheller, J
The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.
Biochim Biophys Acta
1842
1485-94
2014
Homo sapiens
Romi, E; Gokhman, I; Wong, E; Antonovsky, N; Ludwig, A; Sagi, I; Saftig, P; Tessier-Lavigne, M; Yaron, A
ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A.
Nat Commun
5
4058
2014
Mus musculus
Milosch, N; Tanriöver, G; Kundu, A; Rami, A; Franēois, JC; Baumkötter, F; Weyer, SW; Samanta, A; Jäschke, A; Brod, F; Buchholz, CJ; Kins, S; Behl, C; Müller, UC; Kögel, D
Holo-APP and G-protein-mediated signaling are required for sAPP?-induced activation of the Akt survival pathway.
Cell Death Dis
5
e1391
2014
Mus sp., Metazoa
?im?ek, E; Aydemir, E; Korcum, AF; Fi?k?n, K
Thalidomide combined with irradiation alters the activity of two proteases.
Mol Med Rep
11
1535-41
2015
Mus musculus
Yang, WS; Kim, HW; Lee, JM; Han, NJ; Lee, MJ; Park, SK
1,25-dihydroxyvitamin D3 causes ADAM10-dependent ectodomain shedding of tumor necrosis factor receptor 1 in vascular smooth muscle cells.
Mol Pharmacol
87
533-42
2015
Homo sapiens
Ebsen, H; Lettau, M; Kabelitz, D; Janssen, O
Subcellular localization and activation of ADAM proteases in the context of FasL shedding in T lymphocytes.
Mol Immunol
65
416-428
2015
Homo sapiens
Flemming, S; Burkard, N; Renschler, M; Vielmuth, F; Meir, M; Schick, MA; Wunder, C; Germer, CT; Spindler, V; Waschke, J; Schlegel, N
Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis.
Cardiovasc Res
107
32-44
2015
Homo sapiens
Corbett, GT; Gonzalez, FJ; Pahan, K
Activation of peroxisome proliferator-activated receptor ? stimulates ADAM10-mediated proteolysis of APP.
Proc Natl Acad Sci U S A
112
8445-50
2015
Mus musculus, Mus sp.
Ren, F; Li, J; Jiang, X; Xiao, K; Zhang, D; Zhao, Z; Ai, J; Hou, C; Jia, Y; Han, G; Xie, L
Plasma soluble Tim-3 emerges as an inhibitor in sepsis: sepsis contrary to membrane Tim-3 on monocytes.
Tissue Antigens
86
325-32
2015
Homo sapiens
Lattenist, L; Ochodnickż, P; Ahdi, M; Claessen, N; Leemans, JC; Satchell, SC; Florquin, S; Gerdes, VE; Roelofs, JJ
Renal endothelial protein C receptor expression and shedding in diabetic nephropathy.
J Thromb Haemost
2016
Homo sapiens
Jones, JC; Brindley, CD; Elder, NH; Myers, MG; Rajala, MW; Dekaney, CM; McNamee, EN; Frey, MR; Shroyer, NF; Dempsey, PJ
Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury.
Cell Mol Gastroenterol Hepatol
7
533-554
2019
Solanum lycopersicum, Mus sp.
Lu, Y; Tan, L; Wang, X
Circular HDAC9/microRNA-138/Sirtuin-1 Pathway Mediates Synaptic and Amyloid Precursor Protein Processing Deficits in Alzheimer's Disease.
Neurosci Bull
35
877-888
2019
Mus sp.
Choi, SI; Lee, B; Woo, JH; Jeong, JB; Jun, I; Kim, EK
APP processing and metabolism in corneal fibroblasts and epithelium as a potential biomarker for Alzheimer's disease.
Exp Eye Res
182
167-174
2019
Homo sapiens
Gorry, M; Yoneyama, T; Vujanovic, L; Moss, ML; Garlin, MA; Miller, MA; Herman, J; Stabile, LP; Vujanovic, NL
Development of flow cytometry assays for measuring cell-membrane enzyme activity on individual cells.
J Cancer
11
702-715
2020
Homo sapiens, Mus musculus
Tang, BL
Enhancing ?-secretase Processing for Alzheimer's Disease-A View on SFRP1.
Brain Sci
10
2020
Homo sapiens, Mus musculus
Andrews, LP; Somasundaram, A; Moskovitz, JM; Szymczak-Workman, AL; Liu, C; Cillo, AR; Lin, H; Normolle, DP; Moynihan, KD; Taniuchi, I; Irvine, DJ; Kirkwood, JM; Lipson, EJ; Ferris, RL; Bruno, TC; Workman, CJ; Vignali, DAA
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding.
Sci Immunol
5
2020
Homo sapiens
Ni, XQ; Zhang, YR; Jia, LX; Lu, WW; Zhu, Q; Ren, JL; Chen, Y; Zhang, LS; Liu, X; Yu, YR; Jia, MZ; Ning, ZP; Du, J; Tang, CS; Qi, YF
Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway.
Aging (Albany NY)
13
5164-5184
2021
Homo sapiens, Mus musculus, Lamina
Aboyoussef, AM; Abdel-Sattar, AR; Abdel-Bakky, MS; Messiha, BAS
Enoxaparin prevents CXCL16/ADAM10-mediated cisplatin renal toxicity: Role of the coagulation system and the transcriptional factor NF-?B.
Life Sci
270
119120
2021
Mus sp.
Gardiner, EE; Karunakaran, D; Shen, Y; Arthur, JF; Andrews, RK; Berndt, MC
Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases.
J Thromb Haemost
5
1530-7
2007
Goose parvovirus, Homo sapiens, Thrombus
Evin, G; Li, QX
Platelets and Alzheimer's disease: Potential of APP as a biomarker.
World J Psychiatry
2
102-113
2012
Homo sapiens
Gavert, N; Conacci-Sorrell, M; Gast, D; Schneider, A; Altevogt, P; Brabletz, T; Ben-Ze'ev, A
L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers.
J Cell Biol
168
633-42
2005
Homo sapiens, Transformation
Kojro, E; Postina, R; Buro, C; Meiringer, C; Gehrig-Burger, K; Fahrenholz, F
The neuropeptide PACAP promotes the {alpha}-secretase pathway for processing the Alzheimer amyloid precursor protein.
FASEB J
20
512-4
2006
Homo sapiens
Gutwein, P; Abdel-Bakky, MS; Schramme, A; Doberstein, K; KƤmpfer-Kolb, N; Amann, K; Hauser, IA; ObermĆ¼ller, N; Bartel, C; Abdel-Aziz, AA; El Sayed, ES; Pfeilschifter, J
CXCL16 Is Expressed in Podocytes and Acts as a Scavenger Receptor for Oxidized Low-Density Lipoprotein.
Am J Pathol
2009
Homo sapiens
Bai, S; Nasser, MW; Wang, B; Hsu, SH; Datta, J; Kutay, H; Yadav, A; Nuovo, G; Kumar, P; Ghoshal, K
MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to Sorafenib.
J Biol Chem
2009
Homo sapiens
Wijeyewickrema, LC; Gardiner, EE; Gladigau, EL; Berndt, MC; Andrews, RK
Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI.
J Biol Chem
285
11793-9
2010
Homo sapiens
Lo Sardo, V; Zuccato, C; Gaudenzi, G; Vitali, B; Ramos, C; Tartari, M; Myre, MA; Walker, JA; Pistocchi, A; Conti, L; Valenza, M; Drung, B; Schmidt, B; Gusella, J; Zeitlin, S; Cotelli, F; Cattaneo, E
An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin.
Nat Neurosci
15
713-21
2012
Danio rerio, Drosophila melanogaster, Deuterostomia, Dictyostelium discoideum
Huang, YJ; Jin, MH; Pi, RB; Zhang, JJ; Ouyang, Y; Chao, XJ; Chen, MH; Liu, PQ; Yu, JC; Ramassamy, C; Dou, J; Chen, XH; Jiang, YM; Qin, J
Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo.
Toxicol Lett
217
184-91
2013
Hippocampus
Shimoda, M; Principe, S; Jackson, HW; Luga, V; Fang, H; Molyneux, SD; Shao, YW; Aiken, A; Waterhouse, PD; Karamboulas, C; Hess, FM; Ohtsuka, T; Okada, Y; Ailles, L; Ludwig, A; Wrana, JL; Kislinger, T; Khokha, R
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.
Nat Cell Biol
16
889-901
2014
Homo sapiens
Schmidt, G; Papatheodorou, P; Aktories, K
Novel receptors for bacterial protein toxins.
Curr Opin Microbiol
23C
55-61
2015
Escherichia coli, Staphylococcus aureus, Clostridioides difficile, Clostridium perfringens
Balic, JJ; Garbers, C; Rose-John, S; Yu, L; Jenkins, BJ
Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling.
Cytokine
92
118-123
2017
Homo sapiens, Mus sp.
Saint-Pol, J; Billard, M; Dornier, E; Eschenbrenner, E; Danglot, L; Boucheix, C; Charrin, S; Rubinstein, E
New insights into the tetraspanin Tspan5 using novel monoclonal antibodies.
J Biol Chem
292
9551-9566
2017
Homo sapiens, Mus musculus
Reinhardt, S; Stoye, N; Luderer, M; Kiefer, F; Schmitt, U; Lieb, K; Endres, K
Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks.
Sci Rep
8
1329
2018
Homo sapiens, Mus musculus, Mus sp.
Keller, MD; Ching, KL; Liang, FX; Dhabaria, A; Tam, K; Ueberheide, BM; Unutmaz, D; Torres, VJ; Cadwell, K
Decoy exosomes provide protection against bacterial toxins.
Nature
579
260-264
2020
Staphylococcus aureus, Homo sapiens, Mus sp., Lethrinidae
Hata, S; Fujishige, S; Araki, Y; Kato, N; Araseki, M; Nishimura, M; Hartmann, D; Saftig, P; Fahrenholz, F; Taniguchi, M; Urakami, K; Akatsu, H; Martins, RN; Yamamoto, K; Maeda, M; Yamamoto, T; Nakaya, T; Gandy, S; Suzuki, T
Alcadein cleavages by APP {alpha}-and {gamma}-secretases generate small peptides p3-Alcs indicating Alzheimer disease-related {gamma}-secretase dysfunction.
J Biol Chem
2009
Homo sapiens
Jing, P; Sa, N; Liu, X; Liu, X; Xu, W
MicroR-140-5p suppresses tumor cell migration and invasion by targeting ADAM10-mediated Notch1 signaling pathway in hypopharyngeal squamous cell carcinoma.
Exp Mol Pathol
100
132-8
2016
Homo sapiens
Sun, SQ; Ren, LJ; Liu, J; Wang, P; Shan, SM
Sevoflurane inhibits migration and invasion of colorectal cancer cells by regulating microRNA-34a/ADAM10 axis.
Neoplasma
2019
2019
Homo sapiens
Liu, Y; Hao, W; Dawson, A; Liu, S; Fassbender, K
Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2.
J Biol Chem
284
3691-9
2009
Homo sapiens
Zhang, Z; Shen, Q; Wu, X; Zhang, D; Xing, D
Activation of PKA/SIRT1 signaling pathway by photobiomodulation therapy reduces A? levels in Alzheimer's disease models.
Aging Cell
19
e13054
2020
Homo sapiens
Buhimschi, IA; Nayeri, UA; Zhao, G; Shook, LL; Pensalfini, A; Funai, EF; Bernstein, IM; Glabe, CG; Buhimschi, CS
Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia.
Sci Transl Med
6
245ra92
2014
Homo sapiens
Liu, D; Zha, L; Liu, Y; Zhao, X; Xu, X; Liu, S; Ma, W; Zheng, J; Shi, M
?2-AR activation promotes cleavage and nuclear translocation of Her2 and metastatic potential of cancer cells.
Cancer Sci
111
4417-4428
2020
Homo sapiens, Mus sp.
Yu, H; Liu, Y; He, B; He, T; Chen, C; He, J; Yang, X; Wang, JZ
Platelet biomarkers for a descending cognitive function: A proteomic approach.
Aging Cell
20
e13358
2021
Homo sapiens
Sommer, A; Fries, A; Cornelsen, I; Speck, N; Koch-Nolte, F; Gimpl, G; Andrä, J; Bhakdi, S; Reiss, K
Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation.
J Biol Chem
287
23678-89
2012
Homo sapiens, Mus musculus, Apis mellifera
Kopitz, C; Gerg, M; Bandapalli, OR; Ister, D; Pennington, CJ; Hauser, S; Flechsig, C; Krell, HW; Antolovic, D; Brew, K; Nagase, H; Stangl, M; von Weyhern, CW; BrĆ¼cher, BL; Brand, K; Coussens, LM; Edwards, DR; KrĆ¼ger, A
Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.
Cancer Res
67
8615-23
2007
Homo sapiens
Garbers, C; Kuck, F; Aparicio-Siegmund, S; Konzak, K; Kessenbrock, M; Sommerfeld, A; Häussinger, D; Lang, PA; Brenner, D; Mak, TW; Rose-John, S; Essmann, F; Schulze-Osthoff, K; Piekorz, RP; Scheller, J
Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).
Cell Cycle
12
2013
Mus sp.
Knƶsel, T; Emde, A; SchlĆ¼ns, K; Chen, Y; JĆ¼rchott, K; Krause, M; Dietel, M; Petersen, I
Immunoprofiles of 11 biomarkers using tissue microarrays identify prognostic subgroups in colorectal cancer.
Neoplasia
7
741-7
2005
Homo sapiens
Puigoriol-Illamola, D; Leiva, R; Vįzquez-Carrera, M; Vįzquez, S; Grińįn-Ferré, C; Palląs, M
11?-HSD1 Inhibition Rescues SAMP8 Cognitive Impairment Induced by Metabolic Stress.
Mol Neurobiol
2019
Mus sp.
Pasciuto, E; Ahmed, T; Wahle, T; Gardoni, F; D'Andrea, L; Pacini, L; Jacquemont, S; Tassone, F; Balschun, D; Dotti, CG; Callaerts-Vegh, Z; D'Hooge, R; Müller, UC; Di Luca, M; De Strooper, B; Bagni, C
Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.
Neuron
87
382-98
2015
Homo sapiens, Mus musculus
Braley, A; Kwak, T; Jules, J; Harja, E; Landgraf, R; Hudson, BI
Regulation of RAGE ectodomain shedding and its role in cell function.
J Biol Chem
2016
Homo sapiens, Mus musculus
Yang, WS; Kim, JJ; Han, NJ; Lee, EK; Park, SK
1,25-Dihydroxyvitamin D3 Attenuates the Effects of Lipopolysaccharide by Causing ADAM10-Dependent Ectodomain Shedding of Toll-Like Receptor 4.
Cell Physiol Biochem
41
2104-2116
2017
Homo sapiens
Döbel, T; Kunze, A; Babatz, J; Tränkner, K; Ludwig, A; Schmitz, M; Enk, A; Schäkel, K
Fc?RIII (CD16) equips immature 6-sulfo LacNAc-expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens.
Blood
2013
Homo sapiens
Bekris, LM; Galloway, NM; Millard, S; Lockhart, D; Li, G; Galasko, DR; Farlow, MR; Clark, CM; Quinn, JF; Kaye, JA; Schellenberg, GD; Leverenz, JB; Seubert, P; Tsuang, DW; Peskind, ER; Yu, CE
Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease.
Neurobiol Aging
32
556.e13-23
2011
Homo sapiens
KƤrkkƤinen, I; Rybnikova, E; Pelto-Huikko, M; Huovila, AP
Metalloprotease-disintegrin (ADAM) genes are widely and differentially expressed in the adult CNS.
Mol Cell Neurosci
15
547-60
2000
Rodentia
Kim, DY; Ingano, LA; Carey, BW; Pettingell, WH; Kovacs, DM
Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration.
J Biol Chem
280
23251-61
2005
Cricetulus griseus
Endres, K; Postina, R; Schroeder, A; Mueller, U; Fahrenholz, F
Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases.
FEBS J
272
5808-20
2005
Mus musculus
Uemura, K; Kuzuya, A; Aoyagi, N; Ando, K; Shimozono, Y; Ninomiya, H; Shimohama, S; Kinoshita, A
Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor.
Neuroscience
145
5-10
2007
Mus musculus
Galichet, A; Weibel, M; Heizmann, CW
Calcium-regulated intramembrane proteolysis of the RAGE receptor.
Biochem Biophys Res Commun
370
1-5
2008
Homo sapiens
Hou, Y; Yu, YB; Liu, G; Luo, Y
A natural squamosamide derivative FLZ reduces amyloid-beta production by increasing non-amyloidogenic AbetaPP processing.
J Alzheimers Dis
18
153-65
2009
Hippocampus, Mus musculus
Cook, A; Hippensteel, R; Shimizu, S; Nicolai, J; Fatatis, A; Meucci, O
Interactions between chemokines: regulation of fractalkine/CX3CL1 homeostasis by SDF/CXCL12 in cortical neurons.
J Biol Chem
285
10563-71
2010
Rattus
Patil, SP; Maki, S; Khedkar, SA; Rigby, AC; Chan, C
Withanolide A and asiatic acid modulate multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance.
J Nat Prod
73
1196-202
2010
Rattus, plant
Bermejo-Bescós, P; Martķn-Aragón, S; Jiménez-Aliaga, K; Benedķ, J; Felici, E; Gil, P; Ribera, JM; Villar, AM
Processing of the platelet amyloid precursor protein in the mild cognitive impairment (MCI).
Neurochem Res
38
1415-23
2013
Homo sapiens
Duzyj, CM; Buhimschi, IA; Motawea, H; Laky, CA; Cozzini, G; Zhao, G; Funai, EF; Buhimschi, CS
The invasive phenotype of placenta accreta extravillous trophoblasts associates with loss of E-cadherin.
Placenta
36
645-51
2015
Homo sapiens
Cai, ZX; Guo, HS; Wang, C; Wei, M; Cheng, C; Yang, ZF; Chen, YW; Le, WD; Li, S
Double-Edged Roles of Nitric Oxide Signaling on APP Processing and Amyloid-? Production In Vitro: Preliminary Evidence from Sodium Nitroprusside.
Neurotox Res
29
21-34
2016
Homo sapiens
Chen, AC; Kim, S; Shepardson, N; Patel, S; Hong, S; Selkoe, DJ
Physical and functional interaction between the ?- and ?-secretases: A new model of regulated intramembrane proteolysis.
J Cell Biol
211
1157-76
2015
Mus musculus
Cai, Z; Liu, Z; Xiao, M; Wang, C; Tian, F
Chronic Cerebral Hypoperfusion Promotes Amyloid-Beta Pathogenesis via Activating ?/?-Secretases.
Neurochem Res
2017
Hippocampus, Rattus
Jiang, F; Sun, FX; Xu, SM
[Effect of ?sheet blocking peptide H102 on APP metabolic enzymes in hippocampal brain of double transgenic AD mice].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
33
299-303
2017
Hippocampus, Mus sp.
Xian-Hui, D; Dong-Xue, M; Tian-Ci, Z; Xiao-Ping, H; Li-Jun, X; Ya-Lei, L; Hao, L; Wei-Juan, G
The Effect of TCM-Induced HAMP on Key Enzymes in the Hydrolysis of AD Model Cells.
Neurochem Res
46
1068-1080
2021
Astragalus, Radix, Epimedium
Dreymueller, D; Pruessmeyer, J; Groth, E; Ludwig, A
The role of ADAM-mediated shedding in vascular biology.
Eur J Cell Biol
2011
animal
Healy, EF; King, PJ
A mechanism of action for small heat shock proteins.
Biochem Biophys Res Commun
417
268-73
2012
Mycobacterium tuberculosis
Narasingapa, RB; Jargaval, MR; Pullabhatla, S; Htoo, HH; Rao, JK; Hernandez, JF; Govitrapong, P; Vincent, B
Activation of ?-secretase by curcumin-aminoacid conjugates.
Biochem Biophys Res Commun
424
691-6
2012
Homo sapiens
Alabi, RO; Glomski, K; Haxaire, C; Weskamp, G; Monette, S; Blobel, CP
ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds.
Circ Res
119
519-31
2016
Mus sp.
Smulski, CR; Kury, P; Seidel, LM; Staiger, HS; Edinger, AK; Willen, L; Seidl, M; Hess, H; Salzer, U; Rolink, AG; Rizzi, M; Schneider, P; Eibel, H
BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.
Cell Rep
18
2189-2202
2017
Homo sapiens
Maurer, S; Kropp, KN; Klein, G; Steinle, A; Haen, SP; Walz, JS; Hinterleitner, C; Märklin, M; Kopp, HG; Salih, HR
Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells.
Oncoimmunology
7
e1364827
2018
Homo sapiens
Di Luca, M; Grossi, E; Borroni, B; Zimmermann, M; Marcello, E; Colciaghi, F; Gardoni, F; Intraligi, M; Padovani, A; Buscema, M
Artificial neural networks allow the use of simultaneous measurements of Alzheimer disease markers for early detection of the disease.
J Transl Med
3
30
2005
Homo sapiens
Mitsuoka, H; Kume, N; Hayashida, K; Inui-Hayashiada, A; Aramaki, Y; Toyohara, M; Jinnai, T; Nishi, E; Kita, T
Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1 (sLOX-1).
Atherosclerosis
202
176-82
2009
Mus musculus
Amadio, M; Pascale, A; Wang, J; Ho, L; Quattrone, A; Gandy, S; Haroutunian, V; Racchi, M; Pasinetti, GM
nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing.
J Alzheimers Dis
16
409-19
2009
Homo sapiens
Jarvis, CI; Goncalves, MB; Clarke, E; Dogruel, M; Kalindjian, SB; Thomas, SA; Maden, M; Corcoran, JP
Retinoic acid receptor-? signalling antagonizes both intracellular and extracellular amyloid-? production and prevents neuronal cell death caused by amyloid-?.
Eur J Neurosci
32
1246-55
2010
Mus musculus
Raitoharju, E; Seppälä, I; Levula, M; Kuukasjärvi, P; Laurikka, J; Nikus, K; Huovila, AP; Oksala, N; Klopp, N; Illig, T; Laaksonen, R; Karhunen, PJ; Viik, J; Lehtinen, R; Pelto-Huikko, M; Tarkka, M; Kähönen, M; Lehtimäki, T
Common variation in the ADAM8 gene affects serum sADAM8 concentrations and the risk of myocardial infarction in two independent cohorts.
Atherosclerosis
2011
Homo sapiens, Areas
Grabowska, MM; Sandhu, B; Day, ML
EGF promotes the shedding of soluble E-cadherin in an ADAM10-dependent manner in prostate epithelial cells.
Cell Signal
24
532-8
2012
Homo sapiens
Zocchi, MR; Catellani, S; Canevali, P; Tavella, S; Garuti, A; Villaggio, B; Zunino, A; Gobbi, M; Fraternali-Orcioni, G; Kunkl, A; Ravetti, JL; Boero, S; Musso, A; Poggi, A
High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.
Blood
119
1479-89
2012
Homo sapiens
Garcia, AJ; Tom, C; Guemes, M; Polanco, G; Mayorga, ME; Wend, K; Miranda-Carboni, GA; Krum, SA
ER? signaling regulates MMP3 expression to induce FasL cleavage and osteoclast apoptosis.
J Bone Miner Res
2012
Mus sp.
Morales, JK; Saleem, SJ; Martin, RK; Saunders, BL; Barnstein, BO; Faber, TW; Pullen, NA; Kolawole, EM; Brooks, KB; Norton, SK; Sturgill, J; Graham, L; Bear, HD; Urban, JF; Lantz, CS; Conrad, DH; Ryan, JJ
Myeloid-derived suppressor cells enhance IgE-mediated mast cell responses.
J Leukoc Biol
95
643-50
2014
Mus musculus
Na, KY; Kim, HS; Jung, WW; Sung, JY; Kalil, RK; Kim, YW; Park, YK
CXCL16 and CXCR6 in Ewing sarcoma family tumor.
Hum Pathol
45
753-60
2014
Homo sapiens
Chen, CL; Wu, JC; Chen, GY; Yuan, PH; Tseng, YW; Li, KC; Hwang, SM; Hu, YC
Baculovirus-Mediated miRNA Regulation to Suppress Hepatocellular Carcinoma Tumorigenicity and Metastasis.
Mol Ther
2014
Porifera
Sakry, D; Neitz, A; Singh, J; Frischknecht, R; Marongiu, D; Binamé, F; Perera, SS; Endres, K; Lutz, B; Radyushkin, K; Trotter, J; Mittmann, T
Oligodendrocyte precursor cells modulate the neuronal network by activity-dependent ectodomain cleavage of glial NG2.
PLoS Biol
12
e1001993
2014
Mus sp.
Flierl, U; Bauersachs, J; Schäfer, A
Modulation of platelet and monocyte function by the chemokine fractalkine (CX3 CL1) in cardiovascular disease.
Eur J Clin Invest
45
624-33
2015
Ursidae
Hernįndez-Zimbrón, LF; Rivas-Arancibia, S
Oxidative stress caused by ozone exposure induces ?-amyloid 1-42 overproduction and mitochondrial accumulation by activating the amyloidogenic pathway.
Neuroscience
304
340-8
2015
Rattus
Facey, A; Pinar, I; Arthur, JF; Qiao, J; Jing, J; Mado, B; Carberry, J; Andrews, RK; Gardiner, EE
A-Disintegrin-And-Metalloproteinase (ADAM) 10 Activity on Resting and Activated Platelets.
Biochemistry
55
1187-94
2016
Homo sapiens
Liu, B; Ma, A; Zhang, F; Wang, Y; Li, Z; Li, Q; Xu, Z; Zheng, Y
MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis.
Sci Rep
6
21534
2016
Homo sapiens
Yang, WS; Moon, SY; Lee, MJ; Park, SK
Epigallocatechin-3-Gallate Attenuates the Effects of TNF-? in Vascular Endothelial Cells by Causing Ectodomain Shedding of TNF Receptor 1.
Cell Physiol Biochem
38
1963-74
2016
Homo sapiens
Terabe, K; Takahashi, N; Takemoto, T; Knudson, W; Ishiguro, N; Kojima, T
Simvastatin inhibits CD44 fragmentation in chondrocytes.
Arch Biochem Biophys
604
1-10
2016
Bos taurus
Koistinen, NA; Edlund, AK; Menon, PK; Ivanova, EV; Bacanu, S; Iverfeldt, K
Nuclear localization of amyloid-? precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis.
PLoS One
12
e0173888
2017
Homo sapiens
Reyat, JS; Chimen, M; Noy, PJ; Szyroka, J; Rainger, GE; Tomlinson, MG
ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.
J Immunol
199
666-676
2017
Homo sapiens
Yang, WS; Moon, SY; Lee, MJ; Lee, EK; Park, SK
Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-? by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1.
Cell Physiol Biochem
43
2434-2445
2017
Homo sapiens
Kim, YJ; Yoo, JY; Kim, OS; Kim, HB; Ryu, J; Kim, HS; Lee, JH; Yoo, HI; Song, DY; Baik, TK; Woo, RS
Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing.
J Pharmacol Sci
137
146-153
2018
Homo sapiens, Rattus, Hippocampus
Miyoshi, A; Koyama, S; Sasagawa-Monden, M; Kadoya, M; Konishi, K; Shoji, T; Inaba, M; Yamamoto, Y; Koyama, H
JNK and ATF4 as two important platforms for tumor necrosis factor-?-stimulated shedding of receptor for advanced glycation end products.
FASEB J
fj201701553RR
2018
Homo sapiens
Yang, H; Qiu, B; Chen, S; Xun, Y; Pan, Y; Chen, M; Li, WX; Liao, W; El-Ashram, S; Yang, A; Liu, F
Soluble CXCL16 promotes TNF-?-induced apoptosis in DLBCL via the AMAD10-NF-?B regulatory feedback loop.
Cell Biol Int
43
863-874
2019
Homo sapiens
Chen, F; Wang, Y; Zhang, W; Cai, Y; Zhao, T; Mai, H; Tao, S; Wei, W; Li, J; Chen, X; Li, X; Tang, P; Fan, W; Yang, J; Ou, M; Lu, F; Lai, Z; Chen, H; Zou, T; Sun, F; Shao, Y; Cui, L
A Functional Polymorphism-Mediated Disruption of EGR1/ADAM10 Pathway Confers the Risk of Sepsis Progression.
MBio
10
2019
Homo sapiens
Loganathan, SK; Schleicher, K; Malik, A; Quevedo, R; Langille, E; Teng, K; Oh, RH; Rathod, B; Tsai, R; Samavarchi-Tehrani, P; Pugh, TJ; Gingras, AC; Schramek, D
Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling.
Science
367
1264-1269
2020
Homo sapiens
Shao, M; Yu, M; Zhao, J; Mei, J; Pan, Y; Zhang, J; Wu, H; Yu, M; Liu, F; Chen, G
miR-21-3p regulates AGE/RAGE signalling and improves diabetic atherosclerosis.
Cell Biochem Funct
2020
Homo sapiens
de Oliveira, TR; Erbereli, CR; Manzine, PR; Magalhćes, TNC; Balthazar, MLF; Cominetti, MR; Faria, RC
Early Diagnosis of Alzheimer's Disease in Blood Using a Disposable Electrochemical Microfluidic Platform.
ACS Sens
5
1010-1019
2020
Homo sapiens
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