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Abscess
Targeting Staphylococcus aureus ?-Toxin as a Novel Approach to Reduce Severity of Recurrent Skin and Soft-Tissue Infections.
Acantholysis
The involvement of ADAM10 in mucocutaneous pemphigus vulgaris acantholysis depends on the autoantibody profile in each patient.
Acute Coronary Syndrome
Soluble CLEC-2 is generated independently of ADAM10 and is increased in plasma in acute coronary syndrome: comparison with soluble GPVI.
adam 17 endopeptidase deficiency
ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis.
adam10 endopeptidase deficiency
ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis.
adam10 endopeptidase deficiency
Adam10 Mediates the Choice between Principal Cells and Intercalated Cells in the Kidney.
adam10 endopeptidase deficiency
ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage.
adam10 endopeptidase deficiency
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.
adam10 endopeptidase deficiency
Myeloid A Disintegrin and Metalloproteinase Domain 10 Deficiency Modulates Atherosclerotic Plaque Composition by Shifting the Balance from Inflammation toward Fibrosis.
adam10 endopeptidase deficiency
Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17.
adam10 endopeptidase deficiency
Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone.
adam10 endopeptidase deficiency
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Adenocarcinoma
A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding.
Adenocarcinoma
ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort.
Adenocarcinoma
MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus.
Albuminuria
Urinary podocyte-associated mRNA levels correlate with proximal tubule dysfunction in early diabetic nephropathy of type 2 diabetes mellitus.
Alzheimer Disease
A Connected Network of Interacting Proteins Is Involved in Human-Tau Toxicity in Drosophila.
Alzheimer Disease
A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10.
Alzheimer Disease
Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway.
Alzheimer Disease
Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model.
Alzheimer Disease
ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein.
Alzheimer Disease
ADAM10 as a Biomarker for Alzheimer's Disease: A Study with Brazilian Elderly.
Alzheimer Disease
ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer's disease.
Alzheimer Disease
ADAM10 expression and promoter haplotype in Alzheimer's disease.
Alzheimer Disease
ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects.
Alzheimer Disease
ADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker.
Alzheimer Disease
ADAM10 Plasma and CSF Levels Are Increased in Mild Alzheimer's Disease.
Alzheimer Disease
ADAM10 prodomain mutations cause late-onset Alzheimer's disease: not just the latest FAD.
Alzheimer Disease
ADAM10 sheddase activation is controlled by cell membrane asymmetry.
Alzheimer Disease
ADAM9 inhibition increases membrane activity of ADAM10 and controls ?-secretase processing of amyloid precursor protein.
Alzheimer Disease
Alpha-secretase activation--an approach to Alzheimer's disease therapy.
Alzheimer Disease
Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer's Disease Treatment.
Alzheimer Disease
Alpha-secretase as a therapeutic target.
Alzheimer Disease
Amyloid-? Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena.
Alzheimer Disease
An arginine stretch limits ADAM10 exit from the endoplasmic reticulum.
Alzheimer Disease
Apolipoprotein E-mediated Modulation of ADAM10 in Alzheimer's Disease.
Alzheimer Disease
Artificial neural networks allow the use of simultaneous measurements of Alzheimer disease markers for early detection of the disease.
Alzheimer Disease
Association of ADAM10 gene variants with sporadic Parkinson's disease in Chinese Han population.
Alzheimer Disease
Autophagy-Dependent Increased ADAM10 Mature Protein Induced by TFEB Overexpression Is Mediated Through PPAR?.
Alzheimer Disease
Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease.
Alzheimer Disease
Chia Seed Does Not Improve Cognitive Impairment in SAMP8 Mice Fed with High Fat Diet.
Alzheimer Disease
Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain.
Alzheimer Disease
Correlation between mini-mental state examination and platelet ADAM10 expression in Alzheimer's disease.
Alzheimer Disease
Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5'UTR and PI3K Signaling.
Alzheimer Disease
Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice.
Alzheimer Disease
Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5' Untranslated Region (UTR) of Its mRNA.
Alzheimer Disease
Dyschromatosis symmetrica hereditaria and reticulate acropigmentation of Kitamura: An update.
Alzheimer Disease
Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease.
Alzheimer Disease
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.
Alzheimer Disease
Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
Alzheimer Disease
Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer Disease.
Alzheimer Disease
Extract of Caragana sinica as a potential therapeutic option for increasing alpha-secretase gene expression.
Alzheimer Disease
Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system.
Alzheimer Disease
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
Alzheimer Disease
GDE2-RECK controls ADAM10 ?-secretase-mediated cleavage of amyloid precursor protein.
Alzheimer Disease
Genetic association between ADAM10 gene polymorphism and Alzheimer's disease in a Northern Han Chinese population.
Alzheimer Disease
Genetic Association Between APP, ADAM10 Gene Polymorphism, and Sporadic Alzheimer's Disease in the Chinese Population.
Alzheimer Disease
Genomic structure and functional characterization of the human ADAM10 promoter.
Alzheimer Disease
Histone deacetylase inhibitor apicidin increases expression of the ?-secretase ADAM10 through transcription factor USF1-mediated mechanisms.
Alzheimer Disease
Identification of Phlogacantholide C as a Novel ADAM10 Enhancer from Traditional Chinese Medicinal Plants.
Alzheimer Disease
Increase of ?-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging.
Alzheimer Disease
Increased CSF APPs-? levels in patients with Alzheimer disease treated with acitretin.
Alzheimer Disease
Influence of ADAM10 Polymorphisms on Plasma Level of Soluble Receptor for Advanced Glycation End Products and The Association With Alzheimer's Disease Risk.
Alzheimer Disease
Inhibitory mechanism of O-methylated quercetins, highly potent ?-secretase inhibitors isolated from Caragana balchaschensis (Kom.) Pojark.
Alzheimer Disease
Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence.
Alzheimer Disease
Levels of ADAM10 are reduced in Alzheimer's disease CSF.
Alzheimer Disease
Methyl-CpG Binding Protein 2 in Alzheimer Dementia.
Alzheimer Disease
microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer's Disease.
Alzheimer Disease
Nardilysin, ADAM10, and Alzheimer's disease: of mice and men.
Alzheimer Disease
Nasal Delivery of D-Penicillamine Hydrogel Upregulates a Disintegrin and Metalloprotease 10 Expression via Melatonin Receptor 1 in Alzheimer's Disease Models.
Alzheimer Disease
NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease.
Alzheimer Disease
Over-expression of two different forms of the alpha-secretase ADAM10 affects learning and memory in mice.
Alzheimer Disease
Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease.
Alzheimer Disease
Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.
Alzheimer Disease
Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.
Alzheimer Disease
Promoter Variants of the ADAM10 Gene and Their Roles in Temporal Lobe Epilepsy.
Alzheimer Disease
Protein levels of ADAM10, BACE1, and PSEN1 in platelets and leukocytes of Alzheimer's disease patients.
Alzheimer Disease
Quercetin stimulates the non-amyloidogenic pathway via activation of ADAM10 and ADAM17 gene expression in aluminum chloride-induced Alzheimer's disease rat model.
Alzheimer Disease
Reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimer's disease and Down syndrome brains.
Alzheimer Disease
Regulation of ADAM10 by miR-140-5p and potential relevance for Alzheimer's disease.
Alzheimer Disease
Regulation of alpha-secretase ADAM10 expression and activity.
Alzheimer Disease
Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10.
Alzheimer Disease
Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins.
Alzheimer Disease
S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10.
Alzheimer Disease
Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's disease.
Alzheimer Disease
SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.
Alzheimer Disease
Synaptic dysfunction in Alzheimer's disease: From the role of amyloid ?-peptide to the ?-secretase ADAM10.
Alzheimer Disease
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function.
Alzheimer Disease
Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
Alzheimer Disease
The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.
Alzheimer Disease
The close link between retinoid signalling and the ?-secretase ADAM10 and its potential for treating Alzheimer's disease (commentary on Jarvis et al.).
Alzheimer Disease
The effect of age and obesity on platelet amyloid precursor protein processing and plasma markers of oxidative stress and inflammation.
Alzheimer Disease
The expression of the nicotinic acetylcholine receptor ?3 subunit in the brains of patients with Alzheimer's disease and its effects on ?- and ?-secretases and Notch signal transduction in SH-SY5Y cells.
Alzheimer Disease
The Role of ADAM10 in Alzheimer's Disease.
Alzheimer Disease
The Role of the Anti-Amyloidogenic Secretase ADAM10 in Shedding the APP-Like Proteins.
Alzheimer Disease
The role of the TLR4/NF-?B signaling pathway in A? accumulation in primary hippocampal neurons.
Alzheimer Disease
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
Alzheimer Disease
The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.
Alzheimer Disease
Therapeutic impact of rHuEPO on abnormal platelet APP, BACE 1, presenilin 1, ADAM 10 and A? expressions in chronic kidney disease patients with cognitive dysfunction like Alzheimer's disease: A pilot study.
Alzheimer Disease
Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.
Alzheimer Disease
Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region.
Alzheimer Disease
Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease.
Alzheimer Disease
Variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease.
Alzheimer Disease
Vascular endothelial growth factor improves the cognitive decline of Alzheimer's disease via concurrently inducing the expression of ADAM10 and reducing the expression of ?-site APP cleaving enzyme 1 in Tg2576 mice.
Alzheimer Disease
[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients.
Alzheimer Disease
[Generation and characterization of the adult neuron-specific ADAM10 knock-out mice].
Amelogenesis Imperfecta
ADAM10 is Expressed by Ameloblasts, Cleaves the RELT TNF Receptor Extracellular Domain and Facilitates Enamel Development.
Amyloidosis
ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein.
Amyloidosis
Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration.
Amyloidosis
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
Amyloidosis
YXQN Reduces Alzheimer's Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice.
Anaphylaxis
ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production.
Aneurysm
Role of MicroRNA-103a Targeting ADAM10 in Abdominal Aortic Aneurysm.
Aortic Aneurysm, Abdominal
ADAM10 attenuates the development of abdominal aortic aneurysms in a mouse model.
Aortic Aneurysm, Abdominal
Proteolytically active ADAM10 and ADAM17 carried on membrane microvesicles in human abdominal aortic aneurysms.
Aortic Aneurysm, Abdominal
Role of MicroRNA-103a Targeting ADAM10 in Abdominal Aortic Aneurysm.
Aortic Aneurysm, Thoracic
Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model.
Arthritis
Genetic loci that regulate ectopic calcification in response to knee trauma in LG/J by SM/J advanced intercross mice.
Arthritis
Knockdown of ADAM10 inhibits migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis.
Arthritis
MiR-20a inhibits the progression of human arthritis fibroblast-like synoviocytes and inflammatory factor expression by targeting ADAM10.
Arthritis, Rheumatoid
A disintegrin and metalloprotease-10 is correlated with disease activity and mediates monocyte migration and adhesion in rheumatoid arthritis.
Arthritis, Rheumatoid
ADAM-10 is overexpressed in rheumatoid arthritis synovial tissue and mediates angiogenesis.
Arthritis, Rheumatoid
Knockdown of ADAM10 inhibits migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis.
Arthritis, Rheumatoid
miR?152 inhibits rheumatoid arthritis synovial fibroblast proliferation and induces apoptosis by targeting ADAM10.
Arthritis, Rheumatoid
[Retracted] miR?152 inhibits rheumatoid arthritis synovial fibroblast proliferation and induces apoptosis by targeting ADAM10.
Asthma
A potential new target for asthma therapy: A Disintegrin and Metalloprotease 10 (ADAM10) involvement in murine experimental asthma.
Asthma
ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets.
Asthma
Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10.
Asthma
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.
Asthma
The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands.
Astrocytoma
The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1.
Atherosclerosis
A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis.
Atherosclerosis
A Disintegrin and Metalloproteases (ADAMs) in Cardiovascular, Metabolic and Inflammatory Diseases: Aspects for Theranostic Approaches.
Atherosclerosis
An Association Study on ADAM10 Promoter Polymorphisms and Atherosclerotic Cerebral Infarction in a Chinese Population.
Atherosclerosis
Expression and cellular localization of metalloproteases ADAMs in high graded carotid artery lesions.
Atherosclerosis
LncRNA ZFAS1 confers inflammatory responses and reduces cholesterol efflux in atherosclerosis through regulating miR-654-3p-ADAM10/RAB22A axis.
Atherosclerosis
Long non-coding RNA CDKN2B-AS1 reduces inflammatory response and promotes cholesterol efflux in atherosclerosis by inhibiting ADAM10 expression.
Atherosclerosis
miR-21-3p regulates AGE/RAGE signalling and improves diabetic atherosclerosis.
Atherosclerosis
Myeloid A Disintegrin and Metalloproteinase Domain 10 Deficiency Modulates Atherosclerotic Plaque Composition by Shifting the Balance from Inflammation toward Fibrosis.
Autoimmune Diseases
The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship.
Bacterial Infections
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.
Blister
ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis.
Brain Diseases
ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer's disease.
Brain Diseases
The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.
Brain Injuries
Pharmacologic Inhibition of ADAM10 Attenuates Brain Tissue Loss, Axonal Injury and Pro-inflammatory Gene Expression Following Traumatic Brain Injury in Mice.
Brain Injuries, Traumatic
MiR-144 promotes ?-amyloid accumulation-induced cognitive impairments by targeting ADAM10 following traumatic brain injury.
Brain Injuries, Traumatic
MT5-MMP, ADAM-10, and N-cadherin act in concert to facilitate synapse reorganization after traumatic brain injury.
Brain Injuries, Traumatic
Pharmacologic Inhibition of ADAM10 Attenuates Brain Tissue Loss, Axonal Injury and Pro-inflammatory Gene Expression Following Traumatic Brain Injury in Mice.
Brain Injuries, Traumatic
Plasma PrPC and ADAM-10 as novel biomarkers for traumatic brain injury and concussion: a pilot study.
Brain Neoplasms
Drug Blocks Synaptic Hijacking in Gliomas.
Breast Neoplasms
ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPc.
Breast Neoplasms
ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer.
Breast Neoplasms
ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties.
Breast Neoplasms
ADAM10: a new player in breast cancer progression?
Breast Neoplasms
ADAM9 inhibition increases membrane activity of ADAM10 and controls ?-secretase processing of amyloid precursor protein.
Breast Neoplasms
Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells.
Breast Neoplasms
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate.
Breast Neoplasms
Effects of ADAM10 and ADAM17 Inhibitors on Natural Killer Cell Expansion and Antibody-dependent Cellular Cytotoxicity Against Breast Cancer Cells
Breast Neoplasms
Elevated serum HER-2 predicts poor prognosis in breast cancer and is correlated to ADAM10 expression.
Breast Neoplasms
Endostatin and irradiation modifies the activity of ADAM10 and neprilysin in breast cancer cells.
Breast Neoplasms
Fas/FasL-dependent and -independent activation of caspase-8 in doxorubicin-treated human breast cancer MCF-7 cells: ADAM10 down-regulation activates Fas/FasL signaling pathway.
Breast Neoplasms
How ADAM-9 and ADAM-11 differentially from estrogen receptor predict response to tamoxifen treatment in patients with recurrent breast cancer: a retrospective study.
Breast Neoplasms
Human mesenchymal stem cells induce E-cadherin degradation in breast carcinoma spheroids by activating ADAM10.
Breast Neoplasms
Identification of ADAM10 as a Major Source of HER2 Ectodomain Sheddase Activity in HER2 Overexpressing Breast Cancer Cells.
Breast Neoplasms
Increased expression of ADAM family members in human breast cancer and breast cancer cell lines.
Breast Neoplasms
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.
Breast Neoplasms
Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array.
Breast Neoplasms
Mesenchymal stem cells: "repair cells" that serve wounds and cancer?
Breast Neoplasms
miR-365 inhibits cell invasion and migration of triple negative breast cancer through ADAM10.
Breast Neoplasms
MiR-891a-5p as a prognostic marker and therapeutic target for hormone receptor-positive breast cancer.
Breast Neoplasms
Novel role of APP cleavage by ADAM10 for breast cancer metastasis.
Breast Neoplasms
Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer.
Breast Neoplasms
Thalidomide combined with irradiation alters the activity of two proteases.
Breast Neoplasms
The association of the expression of miR-122-5p and its target ADAM10 with human breast cancer.
Breast Neoplasms
The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands.
Breast Neoplasms
Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells.
Candidiasis
IL-1{beta} and ADAM17 are central regulators of {beta}-defensin expression in Candida esophagitis.
Carcinogenesis
ADAM10 mediates the cell invasion and metastasis of human esophageal squamous cell carcinoma via regulation of E-cadherin activity.
Carcinogenesis
ADAM10 sheddase activation is controlled by cell membrane asymmetry.
Carcinogenesis
CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways.
Carcinogenesis
Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma.
Carcinogenesis
MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to Sorafenib.
Carcinogenesis
N-Cadherin, ADAM-10 and Aquaporin 1 expression in lung tissue exposed to fluoro-edenite fibers: an immunohistochemical study.
Carcinogenesis
Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis.
Carcinogenesis
Tetraspanin CD9 interacts with ?-secretase to enhance its oncogenic function in pancreatic cancer.
Carcinogenesis
Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells.
Carcinogenesis
Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular carcinomas.
Carcinoma
Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas.
Carcinoma
ADAM 10 is over expressed in oral squamous cell carcinoma and contributes to invasive behaviour through a functional association with ?v?6 integrin.
Carcinoma
ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort.
Carcinoma
ADAM10 mediates the cell invasion and metastasis of human esophageal squamous cell carcinoma via regulation of E-cadherin activity.
Carcinoma
ADAMs (a disintegrin and metalloproteinase) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa.
Carcinoma
Clinical significance of ADAM10 expression in laryngeal carcinoma.
Carcinoma
Effect of A disintegrin and metalloproteinase 10 gene silencing on the proliferation, invasion and migration of the human tongue squamous cell carcinoma cell line TCA8113.
Carcinoma
Expression of A disintegrin and metalloprotease 10 in pancreatic carcinoma.
Carcinoma
Expression of ADAM10, Fas, FasL and Soluble FasL in Patients with Oral Squamous Cell Carcinoma (OSCC) and their Association with Clinical-Pathological Parameters.
Carcinoma
Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference.
Carcinoma
MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus.
Carcinoma
MiR-449a regulates the cell migration and invasion of human non-small cell lung carcinoma by targeting ADAM10.
Carcinoma
Nuclear translocation and signaling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity.
Carcinoma
Overexpression of A disintegrin and metalloprotease 10 promotes tumor proliferation, migration and poor prognosis in hypopharyngeal squamous cell carcinoma.
Carcinoma
Overexpression of ADAM10 in oral squamous cell carcinoma with metastases.
Carcinoma
Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells.
Carcinoma
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding.
Carcinoma
The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas.
Carcinoma
The disintegrin-metalloproteinases ADAM10 and ADAM17 are upregulated in cutaneous squamous cell carcinomas.
Carcinoma
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.
Carcinoma
Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients.
Carcinoma
Upregulation of ADAM10 in oral squamous cell carcinoma and its correlation with EGFR, neoangiogenesis and clinicopathologic factors.
Carcinoma
[miR-140-5p affects the migration and invasion of hypopharyngeal carcinoma cells by downregulating ADAM10 expression].
Carcinoma, Adenoid Cystic
Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference.
Carcinoma, Basal Cell
The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas.
Carcinoma, Hepatocellular
ADAM10 is overexpressed in human hepatocellular carcinoma and contributes to the proliferation, invasion and migration of HepG2 cells.
Carcinoma, Hepatocellular
ADAM10 overexpression confers resistance to doxorubicin-induced apoptosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Anticancer Chemotherapy Inhibits MHC Class I-Related Chain A Ectodomain Shedding by Downregulating ADAM10 Expression in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Downregulation of ADAM10 Expression Inhibits Metastasis and Invasiveness of Human Hepatocellular Carcinoma HepG2 Cells.
Carcinoma, Hepatocellular
Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-451a represses epithelial-mesenchymal transition of hepatocellular carcinoma cells by inhibiting ADAM10.
Carcinoma, Hepatocellular
Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics.
Carcinoma, Hepatocellular
Knockout of ADAM10 enhances sorafenib antitumor activity of hepatocellular carcinoma in vitro and in vivo.
Carcinoma, Hepatocellular
Long noncoding LINC01551 promotes hepatocellular carcinoma cell proliferation, migration, and invasion by acting as a competing endogenous RNA of microRNA-122-5p to regulate ADAM10 expression.
Carcinoma, Hepatocellular
MicroRNA-655-3p functions as a tumor suppressor by regulating ADAM10 and ?-catenin pathway in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
miR-365 targets ADAM10 and suppresses the cell growth and metastasis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
miR-449a inhibits proliferation and invasion by regulating ADAM10 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Novel therapeutic features of disulfiram against hepatocellular carcinoma cells with inhibitory effects on a disintegrin and metalloproteinase 10.
Carcinoma, Hepatocellular
Retracted: Downregulation of ADAM10 expression inhibits metastasis and invasiveness of human hepatocellular carcinoma HepG2 cells.
Carcinoma, Hepatocellular
Retraction.
Carcinoma, Hepatocellular
Silencing ADAM10 inhibits the in vitro and in vivo growth of hepatocellular carcinoma cancer cells.
Carcinoma, Hepatocellular
Synergistic effects of co-expression plasmid?based ADAM10-specific siRNA and GRIM-19 on hepatocellular carcinoma in vitro and in vivo.
Carcinoma, Hepatocellular
Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular carcinomas.
Carcinoma, Non-Small-Cell Lung
ADAM10 overexpression in human non-small cell lung cancer correlates with cell migration and invasion through the activation of the Notch1 signaling pathway.
Carcinoma, Non-Small-Cell Lung
CircNFIX Acts as a miR-212-3p Sponge to Enhance the Malignant Progression of Non-Small Cell Lung Cancer by Up-Regulating ADAM10.
Carcinoma, Non-Small-Cell Lung
MiR-449a regulates the cell migration and invasion of human non-small cell lung carcinoma by targeting ADAM10.
Carcinoma, Papillary
Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients.
Carcinoma, Renal Cell
Suppression of tunicamycin-induced CD44v6 ectodomain shedding and apoptosis is correlated with temporal expression patterns of active ADAM10, MMP-9 and MMP-13 proteins in Caki-2 renal carcinoma cells.
Carcinoma, Renal Cell
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.
Carcinoma, Renal Cell
Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients.
Carcinoma, Squamous Cell
Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas.
Carcinoma, Squamous Cell
Effect of A disintegrin and metalloproteinase 10 gene silencing on the proliferation, invasion and migration of the human tongue squamous cell carcinoma cell line TCA8113.
Carcinoma, Squamous Cell
MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus.
Carcinoma, Squamous Cell
Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells.
Carcinoma, Squamous Cell
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding.
Carcinoma, Squamous Cell
The disintegrin-metalloproteinases ADAM10 and ADAM17 are upregulated in cutaneous squamous cell carcinomas.
Cardiomyopathies
Interrelation between Expression of ADAM 10 and MMP 9 and Synthesis of Peroxynitrite in Doxorubicin Induced Cardiomyopathy.
Cardiomyopathies
[Improvement and the mechanism of cardiac function by knockdown of ADAM10 in adriamycin-induced cardiomyopathy rats].
Cardiomyopathy, Dilated
Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy.
Cardiovascular Diseases
Ionising radiation increases permeability of endothelium through ADAM10-mediated cleavage of VE-cadherin.
Cardiovascular Diseases
Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins.
Central Nervous System Diseases
ADAM10 suppresses demyelination and reduces seizure susceptibility in cuprizone-induced demyelination model.
Cerebral Amyloid Angiopathy
Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence.
Cerebral Infarction
An Association Study on ADAM10 Promoter Polymorphisms and Atherosclerotic Cerebral Infarction in a Chinese Population.
Chlamydophila Infections
Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of ?-amyloid found in Alzheimer disease.
Chordoma
ADAM10 Is a Potential Novel Prognostic Biomarker for Sacral Chordoma.
Colonic Neoplasms
Cell fusion promotes chemoresistance in metastatic colon carcinoma.
Colonic Neoplasms
Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis.
Colonic Neoplasms
Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer.
Colorectal Neoplasms
Adamalysines as Biomarkers and a Potential Target of Therapy in Colorectal Cancer Patients: Preliminary Results.
Colorectal Neoplasms
L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers.
Colorectal Neoplasms
Relation between Tetraspanin- Associated and Tetraspanin- Non- Associated Exosomal Proteases and Metabolic Syndrome in Colorectal Cancer Patients
Colorectal Neoplasms
Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients.
Colorectal Neoplasms
Serum levels of ADAM10, ADAM12, ADAM17 AND ADAM28 in colorectal cancer patients.
Colorectal Neoplasms
Soluble Receptor for Advanced Glycation End-products (sRAGE) and Colorectal Cancer Risk: A Case-Control Study Nested within a European Prospective Cohort.
Creutzfeldt-Jakob Syndrome
TREM2 expression in the brain and biological fluids in prion diseases.
Creutzfeldt-Jakob Syndrome
Variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
[Genetic background of human prion diseases]
Cysts
ADAM10-Notch signaling governs the recruitment of ovarian pregranulosa cells and controls folliculogenesis in mice.
Cysts
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling.
Dementia
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A?, tau, immunity and lipid processing.
Dementia
Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer's disease-related dysregulation.
Dementia
Platelets: Peripheral Biomarkers of Dementia?
Demyelinating Diseases
ADAM10 suppresses demyelination and reduces seizure susceptibility in cuprizone-induced demyelination model.
Demyelinating Diseases
Cornel Iridoid Glycoside Ameliorated Alzheimer's Disease-Like Pathologies and Necroptosis through RIPK1/MLKL Pathway in Young and Aged SAMP8 Mice.
Demyelinating Diseases
N-cadherin promotes recruitment and migration of neural progenitor cells from the SVZ neural stem cell niche into demyelinated lesions.
Dermatomyositis
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
Diabetes Mellitus, Type 1
Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes.
Diabetic Nephropathies
CXCL16 and oxLDL are induced in the onset of diabetic nephropathy.
Diabetic Nephropathies
Urinary podocyte-associated mRNA levels correlate with proximal tubule dysfunction in early diabetic nephropathy of type 2 diabetes mellitus.
Diabetic Retinopathy
Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy.
Down Syndrome
Reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimer's disease and Down syndrome brains.
Eczema
ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis.
Encephalitis
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
Encephalitis
Involvement of IRS-1 Interaction with ADAM10 in the Regulation of Neurite Extension.
Endometriosis
ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling.
Eosinophilia
A potential new target for asthma therapy: A Disintegrin and Metalloprotease 10 (ADAM10) involvement in murine experimental asthma.
Epilepsy
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation.
Epilepsy
Promoter Variants of the ADAM10 Gene and Their Roles in Temporal Lobe Epilepsy.
Epilepsy
Regulation of ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.
Epilepsy
Stage-dependent involvement of ADAM10 and its significance in epileptic seizures.
Epilepsy
The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.
Epilepsy, Temporal Lobe
Promoter Variants of the ADAM10 Gene and Their Roles in Temporal Lobe Epilepsy.
Epilepsy, Temporal Lobe
Regulation of ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.
Epiretinal Membrane
Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy.
Esophageal Neoplasms
ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3.
Esophageal Squamous Cell Carcinoma
ADAM10 mediates the cell invasion and metastasis of human esophageal squamous cell carcinoma via regulation of E-cadherin activity.
Fibrosarcoma
Janus kinase 2 influences growth hormone receptor metalloproteolysis.
Fragile X Syndrome
The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.
Gastritis
ADAM proteases involved in inflammation are differentially altered in patients with gastritis or ulcer.
Glioblastoma
ADAM-10 could mediate cleavage of N-cadherin promoting apoptosis in human atherosclerotic lesions leading to vulnerable plaque: A morphological and immunohistochemical study.
Glioblastoma
Characterization of matrix metalloproteinase-2 and -9, ADAM-10 and N-cadherin expression in human glioblastoma multiforme.
Glioblastoma
Metalloproteinases ADAM10 and ADAM17 Mediate Migration and Differentiation in Glioblastoma Sphere-Forming Cells.
Glioma
A-Disintegrin and Metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells.
Glioma
Expression of a-disintegrin and metalloproteinase 10 correlates with grade of malignancy in human glioma.
Glioma
Glioma-derived ADAM10 induces regulatory B cells to suppress CD8+ T cells.
Glioma
L1 stimulation of human glioma cell motility correlates with FAK activation.
Glioma
L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor.
Glioma
NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.
Glomerulonephritis, IGA
ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling.
HIV Infections
Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome.
HIV Infections
Soluble T Cell Immunoglobulin Mucin Domain 3 Is Shed from CD8+ T Cells by the Sheddase ADAM10, Is Increased in Plasma during Untreated HIV Infection, and Correlates with HIV Disease Progression.
Hodgkin Disease
ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing.
Hodgkin Disease
Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models.
Hodgkin Disease
Inhibitors of A Disintegrin And Metalloproteinases-10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect.
Hodgkin Disease
Role of ADAM10 as a CD30 Sheddase in Classical Hodgkin Lymphoma.
Hodgkin Disease
Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells.
Huntington Disease
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.
Huntington Disease
Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease.
Huntington Disease
The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.
Hydronephrosis
Adam10 Mediates the Choice between Principal Cells and Intercalated Cells in the Kidney.
Hyperalgesia
Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury-Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells.
Hypersensitivity
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
Hypersensitivity
Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice.
Hypersensitivity
Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10.
Infections
A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice.
Infections
ADAMs (a disintegrin and metalloproteinase) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa.
Infections
Analysis of cell hyperplasia and parietal cell dysfunction induced by Ostertagia ostertagi infection.
Infections
Apparent Reduction of ADAM10 in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents.
Infections
Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of ?-amyloid found in Alzheimer disease.
Infections
Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus ?-toxin action.
Infections
Genetic Requirement for ADAM10 in Severe Staphylococcus aureus Skin Infection.
Infections
Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo.
Infections
Myeloid-derived suppressor cells enhance IgE-mediated mast cell responses.
Infections
Targeting Staphylococcus aureus ?-Toxin as a Novel Approach to Reduce Severity of Recurrent Skin and Soft-Tissue Infections.
Infections
The sheddase ADAM10 is a potent modulator of prion disease.
Infections
The shedding-derived soluble receptor for advanced glycation endproducts sustains inflammation during acute Pseudomonas aeruginosa lung infection.
Infections
Tissue-specific patterning of host innate immune responses by Staphylococcus aureus ?-toxin.
Infections
Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility.
Infertility
Endothelial deletion of ADAM10, a key regulator of Notch signaling, causes impaired decidualization and reduced fertility in female mice.
Influenza, Human
ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myeloid Cell Population.
Insulin Resistance
Metabolic profiling distinguishes three subtypes of Alzheimer's disease.
Intussusception
Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling.
Iron Overload
The Effect of TCM-Induced HAMP on Key Enzymes in the Hydrolysis of AD Model Cells.
Kidney Diseases
ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases.
Kidney Diseases
Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney.
Kidney Diseases
CXCL16 Is Expressed in Podocytes and Acts as a Scavenger Receptor for Oxidized Low-Density Lipoprotein.
Kidney Failure, Chronic
Association of CD30 transcripts with Th1 responses and proinflammatory cytokines in patients with end-stage renal disease.
Kidney Neoplasms
Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition.
Kidney Neoplasms
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.
Kidney Neoplasms
Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients.
Leukemia
A disintegrin and metalloprotease-10 is correlated with disease activity and mediates monocyte migration and adhesion in rheumatoid arthritis.
Leukemia
An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis.
Leukemia
Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling.
Leukemia
The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.
Leukemia
Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells.
Leukemia
[Effect of ADAM10 Inhibitor GI254023X on Proliferation and Apoptosis of Acute T-Lymphoblastic Leukemia Jurkat Cells In Vitro and Its Possible Mechanisms].
Leukemia, Monocytic, Acute
An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis.
Leukoplakia, Oral
Overexpression of ADAM10 in oral squamous cell carcinoma with metastases.
Liver Cirrhosis
ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis.
Liver Cirrhosis
CX3CL1/FRACTALKINE SHEDDING BY HUMAN HEPATIC STELLATE CELLS: CONTRIBUTION TO CHRONIC INFLAMMATION IN THE LIVER.
Liver Diseases
CX3CL1/FRACTALKINE SHEDDING BY HUMAN HEPATIC STELLATE CELLS: CONTRIBUTION TO CHRONIC INFLAMMATION IN THE LIVER.
Liver Neoplasms
Computational identification and experimental validation of microRNAs binding to the Alzheimerrelated gene ADAM10.
Liver Neoplasms
Knockout of ADAM10 enhances sorafenib antitumor activity of hepatocellular carcinoma in vitro and in vivo.
Lung Neoplasms
ADAM10 overexpression in human non-small cell lung cancer correlates with cell migration and invasion through the activation of the Notch1 signaling pathway.
Lung Neoplasms
CircNFIX Acts as a miR-212-3p Sponge to Enhance the Malignant Progression of Non-Small Cell Lung Cancer by Up-Regulating ADAM10.
Lung Neoplasms
Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells.
Lymphatic Metastasis
ADAM10 mediates the cell invasion and metastasis of human esophageal squamous cell carcinoma via regulation of E-cadherin activity.
Lymphatic Metastasis
Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics.
Lymphatic Metastasis
Overexpression of A disintegrin and metalloprotease 10 promotes tumor proliferation, migration and poor prognosis in hypopharyngeal squamous cell carcinoma.
Lymphoma
Constitutive activation of metalloproteinase ADAM10 in mantle cell lymphoma promotes cell growth and activates the TNF{alpha}/NF{kappa}B pathway.
Lymphoma
High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.
Lymphoma
Inhibitors of A Disintegrin And Metalloproteinases-10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect.
Lymphoma
Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells.
Lymphoma, Mantle-Cell
Constitutive activation of metalloproteinase ADAM10 in mantle cell lymphoma promotes cell growth and activates the TNF{alpha}/NF{kappa}B pathway.
Malformations of Cortical Development
Stage-dependent involvement of ADAM10 and its significance in epileptic seizures.
Melanoma
ADAM 10 expression in primary uveal melanoma as prognostic factor for risk of metastasis.
Melanoma
ADAM10 correlates with uveal melanoma metastasis and promotes in vitro invasion.
Melanoma
ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells.
Melanoma
ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma.
Melanoma
High percentage of ADAM-10 positive melanoma cells correlates with paucity of tumor-infiltrating lymphocytes but does not predict prognosis in cutaneous melanoma patients.
Melanoma
HIV Nef, Paxillin, and Pak1/2 Regulate Activation and Secretion of TACE/ADAM10 Proteases.
Melanoma
Noncanonical Activation of Notch1 Protein by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Controls Melanoma Cell Proliferation.
Melanoma
PAX2 Regulates ADAM10 Expression and Mediates Anchorage-Independent Cell Growth of Melanoma Cells.
Melanoma
Potential Onco-Suppressive Role of miR122 and miR144 in Uveal Melanoma through ADAM10 and C-Met Inhibition.
Melanoma
Shedding light on proteolytic cleavage of CD44: the responsible sheddase and functional significance of shedding.
Melanoma
The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor.
Memory Disorders
Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks.
Mesothelioma
ADAM10 mediates malignant pleural mesothelioma invasiveness.
Mesothelioma, Malignant
ADAM10 mediates malignant pleural mesothelioma invasiveness.
Mouth Neoplasms
Overexpression of ADAM10 in oral squamous cell carcinoma with metastases.
Multiple Myeloma
[Effect of ADAM10 Inhibitor GI254023X on Proliferation and Apoptosis of Multiple Myeloma H929 Cells and Its Possible Mechanisms].
Multiple Myeloma
[Effect of Interfering the ADAM10 by Lentivirul Vector-Mediated shRNA on Multiple Myeloma MM.1S Cell Proliferation].
Multiple Sclerosis
ADAM10 suppresses demyelination and reduces seizure susceptibility in cuprizone-induced demyelination model.
Myeloproliferative Disorders
Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis.
Myeloproliferative Disorders
Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10).
Myocardial Infarction
Common variation in the ADAM8 gene affects serum sADAM8 concentrations and the risk of myocardial infarction in two independent cohorts.
Myocardial Infarction
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.
Myositis
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
Myositis, Inclusion Body
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
Nasal Polyps
Expression of ADAM17 and ADAM10 in nasal polyps.
Nasopharyngeal Carcinoma
Effects of ADAM10 upregulation on progression, migration, and prognosis of nasopharyngeal carcinoma.
Neoplasm Metastasis
Activation of MMP-9 by membrane type-1 MMP/MMP-2 axis stimulates tumor metastasis.
Neoplasm Metastasis
ADAM 10 expression in primary uveal melanoma as prognostic factor for risk of metastasis.
Neoplasm Metastasis
ADAM 10 is associated with gastric cancer progression and prognosis of patients.
Neoplasm Metastasis
ADAM10 correlates with uveal melanoma metastasis and promotes in vitro invasion.
Neoplasm Metastasis
ADAM10 Is a Potential Novel Prognostic Biomarker for Sacral Chordoma.
Neoplasm Metastasis
ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma.
Neoplasm Metastasis
ADAM10 mediates the cell invasion and metastasis of human esophageal squamous cell carcinoma via regulation of E-cadherin activity.
Neoplasm Metastasis
ADAM10 overexpression in human non-small cell lung cancer correlates with cell migration and invasion through the activation of the Notch1 signaling pathway.
Neoplasm Metastasis
Adamalysines as Biomarkers and a Potential Target of Therapy in Colorectal Cancer Patients: Preliminary Results.
Neoplasm Metastasis
Downregulation of ADAM10 Expression Inhibits Metastasis and Invasiveness of Human Hepatocellular Carcinoma HepG2 Cells.
Neoplasm Metastasis
Effects of ADAM10 upregulation on progression, migration, and prognosis of nasopharyngeal carcinoma.
Neoplasm Metastasis
Expression of A disintegrin and metalloprotease 10 in pancreatic carcinoma.
Neoplasm Metastasis
Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis.
Neoplasm Metastasis
Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and ?-catenin signaling.
Neoplasm Metastasis
High percentage of ADAM-10 positive melanoma cells correlates with paucity of tumor-infiltrating lymphocytes but does not predict prognosis in cutaneous melanoma patients.
Neoplasm Metastasis
Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics.
Neoplasm Metastasis
Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference.
Neoplasm Metastasis
Long Non-Coding RNA LUCAT1 Promotes Progression of Thyroid Carcinoma by Reinforcing ADAM10 Expression Through Sequestering microRNA-493.
Neoplasm Metastasis
miR-365 targets ADAM10 and suppresses the cell growth and metastasis of hepatocellular carcinoma.
Neoplasm Metastasis
Novel role of APP cleavage by ADAM10 for breast cancer metastasis.
Neoplasm Metastasis
Overexpression of A disintegrin and metalloprotease 10 promotes tumor proliferation, migration and poor prognosis in hypopharyngeal squamous cell carcinoma.
Neoplasm Metastasis
Overexpression of ADAM10 in oral squamous cell carcinoma with metastases.
Neoplasm Metastasis
PAX2 Regulates ADAM10 Expression and Mediates Anchorage-Independent Cell Growth of Melanoma Cells.
Neoplasm Metastasis
PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion.
Neoplasm Metastasis
Potential Onco-Suppressive Role of miR122 and miR144 in Uveal Melanoma through ADAM10 and C-Met Inhibition.
Neoplasm Metastasis
Proteolytic release of the p75NTR intracellular domain by ADAM10 promotes metastasis and resistance to anoikis.
Neoplasm Metastasis
Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells.
Neoplasm Metastasis
Retracted: Downregulation of ADAM10 expression inhibits metastasis and invasiveness of human hepatocellular carcinoma HepG2 cells.
Neoplasm Metastasis
Silencing ADAM10 inhibits the in vitro and in vivo growth of hepatocellular carcinoma cancer cells.
Neoplasm Metastasis
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.
Neoplasm Metastasis
Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression.
Neoplasm Metastasis
Trop-2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis.
Neoplasm Metastasis
Tspan5 promotes epithelial-mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling.
Neoplasm Metastasis
Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular carcinomas.
Neoplasm Metastasis
[miR-140-5p affects the migration and invasion of hypopharyngeal carcinoma cells by downregulating ADAM10 expression].
Neoplasms
?2-AR activation promotes cleavage and nuclear translocation of Her2 and metastatic potential of cancer cells.
Neoplasms
A Disintegrin and Metalloproteinase 9 (ADAM9) in Advanced Hepatocellular Carcinoma and Their Role as a Biomarker During Hepatocellular Carcinoma Immunotherapy.
Neoplasms
A disintegrin and metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor.
Neoplasms
A novel pan-cancer biomarker plasma heat shock protein 90alpha and its diagnosis determinants in clinic.
Neoplasms
A-Disintegrin and Metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells.
Neoplasms
Aberrant ADAM10 expression correlates with osteosarcoma progression.
Neoplasms
Activation of epidermal growth factor receptor signaling by the prostaglandin E(2) receptor EP4 pathway during gastric tumorigenesis.
Neoplasms
Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas.
Neoplasms
ADAM 10 is associated with gastric cancer progression and prognosis of patients.
Neoplasms
ADAM proteases: Emerging role and targeting of the non-catalytic domains.
Neoplasms
ADAM-10 and ADAM-17 in the inflamed human CNS.
Neoplasms
ADAM-17 expression is enhanced by FoxM1 and is a poor prognostic sign in gastric carcinoma.
Neoplasms
ADAM-17 is a poor prognostic indicator for patients with hilar cholangiocarcinoma and is regulated by FoxM1.
Neoplasms
ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance.
Neoplasms
ADAM10 as a target for anti-cancer therapy.
Neoplasms
ADAM10 as a therapeutic target for cancer and inflammation.
Neoplasms
ADAM10 Evens Out the Double-Edged Sword of Radiotherapy in Pancreatic Cancer.
Neoplasms
ADAM10 is overexpressed in human hepatocellular carcinoma and contributes to the proliferation, invasion and migration of HepG2 cells.
Neoplasms
ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells.
Neoplasms
ADAM10 mediates malignant pleural mesothelioma invasiveness.
Neoplasms
ADAM10 mediates the cell invasion and metastasis of human esophageal squamous cell carcinoma via regulation of E-cadherin activity.
Neoplasms
ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing.
Neoplasms
ADAM10 overexpression confers resistance to doxorubicin-induced apoptosis in hepatocellular carcinoma.
Neoplasms
ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/?-catenin signaling pathway and is regulated by miR-122-5p.
Neoplasms
ADAM10 promotes pituitary adenoma cell migration by regulating cleavage of CD44 and L1.
Neoplasms
ADAM10 regulates proliferation, invasion, and chemoresistance of bladder cancer cells.
Neoplasms
ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker.
Neoplasms
ADAM10 Site-Dependent Biology: Keeping Control of a Pervasive Protease.
Neoplasms
ADAM10: a new player in breast cancer progression?
Neoplasms
ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes.
Neoplasms
ADAMs family members as amyloid precursor protein alpha-secretases.
Neoplasms
ADAMs in cancer cell proliferation and progression.
Neoplasms
Aging-related early changes in markers of ventricular and matrix remodeling after reperfused ST-segment elevation myocardial infarction in the canine model: effect of early therapy with an angiotensin II type 1 receptor blocker.
Neoplasms
An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.
Neoplasms
An arginine stretch limits ADAM10 exit from the endoplasmic reticulum.
Neoplasms
Arginine vasopressin attenuates the effects of TNF-? in aortic endothelial cells by inducing ectodomain shedding of TNF receptor 1.
Neoplasms
BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors.
Neoplasms
Bone morphogenetic protein 15 and fibroblast growth factor 10 enhance cumulus expansion, glucose uptake, and expression of genes in the ovulatory cascade during in vitro maturation of bovine cumulus-oocyte complexes.
Neoplasms
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation.
Neoplasms
Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness.
Neoplasms
CircFOXM1 silencing represses cell proliferation, migration and invasion by regulating miR-515-5p/ADAM10 axis in prostate cancer.
Neoplasms
Constitutive activation of metalloproteinase ADAM10 in mantle cell lymphoma promotes cell growth and activates the TNF{alpha}/NF{kappa}B pathway.
Neoplasms
Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.
Neoplasms
CXCL16 Is Expressed in Podocytes and Acts as a Scavenger Receptor for Oxidized Low-Density Lipoprotein.
Neoplasms
Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state.
Neoplasms
Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments.
Neoplasms
Differential surface expression of ADAM10 and ADAM17 on human T lymphocytes and tumor cells.
Neoplasms
Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models.
Neoplasms
Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival.
Neoplasms
Drosophila TIMP is a potent inhibitor of MMPs and TACE: similarities in structure and function to TIMP-3.
Neoplasms
Editorial: ADAM10 in Cancer Immunology and Autoimmunity: More Than a Simple Biochemical Scissor.
Neoplasms
Effects of ADAM10 upregulation on progression, migration, and prognosis of nasopharyngeal carcinoma.
Neoplasms
EGF promotes the shedding of soluble E-cadherin in an ADAM10-dependent manner in prostate epithelial cells.
Neoplasms
Elevated serum HER-2 predicts poor prognosis in breast cancer and is correlated to ADAM10 expression.
Neoplasms
Endostatin and irradiation modifies the activity of ADAM10 and neprilysin in breast cancer cells.
Neoplasms
Engagement of CD44 promotes Rac activation and CD44 cleavage during tumor cell migration.
Neoplasms
Enhanced antitumor activity of gemcitabine by polysaccharide-induced NK cell activation and immune cytotoxicity reduction in vitro/vivo.
Neoplasms
Enhanced expression of CD31/platelet endothelial cell adhesion molecule 1 (PECAM1) correlates with hypoxia inducible factor-1 alpha (HIF-1?) in human glioblastoma multiforme.
Neoplasms
Enhancing ?-secretase Processing for Alzheimer's Disease-A View on SFRP1.
Neoplasms
Enoxaparin prevents CXCL16/ADAM10-mediated cisplatin renal toxicity: Role of the coagulation system and the transcriptional factor NF-?B.
Neoplasms
Expression of A disintegrin and metalloprotease 10 in pancreatic carcinoma.
Neoplasms
Expression of a-disintegrin and metalloproteinase 10 correlates with grade of malignancy in human glioma.
Neoplasms
Expression of ADAM Proteases in Bladder Cancer Patients with BCG Failure: A Pilot Study.
Neoplasms
Expression of ADAM10, Fas, FasL and Soluble FasL in Patients with Oral Squamous Cell Carcinoma (OSCC) and their Association with Clinical-Pathological Parameters.
Neoplasms
Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas.
Neoplasms
Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP.
Neoplasms
Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and ?-catenin signaling.
Neoplasms
High percentage of ADAM-10 positive melanoma cells correlates with paucity of tumor-infiltrating lymphocytes but does not predict prognosis in cutaneous melanoma patients.
Neoplasms
Human metalloprotease-disintegrin Kuzbanian regulates sympathoadrenal cell fate in development and neoplasia.
Neoplasms
Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition.
Neoplasms
Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
Neoplasms
Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide.
Neoplasms
Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis.
Neoplasms
Identification of ADAM10 as a Major Source of HER2 Ectodomain Sheddase Activity in HER2 Overexpressing Breast Cancer Cells.
Neoplasms
Immunoprofiles of 11 biomarkers using tissue microarrays identify prognostic subgroups in colorectal cancer.
Neoplasms
Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics.
Neoplasms
Improved Synthesis of ADAM10 Inhibitor GI254023X.
Neoplasms
Increased expression of tumor necrosis factor-alpha converting enzyme and tumor necrosis factor-alpha in peripheral blood mononuclear cells in patients with advanced congestive heart failure.
Neoplasms
Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer.
Neoplasms
Inhibitors of A Disintegrin And Metalloproteinases-10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect.
Neoplasms
Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling.
Neoplasms
Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alpha.
Neoplasms
Ionizing radiation increases the endothelial permeability and the transendothelial migration of tumor cells through ADAM10-activation and subsequent degradation of VE-cadherin.
Neoplasms
Knockdown of ADAM10 inhibits migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis.
Neoplasms
L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas.
Neoplasms
LC-MS Based Cleavage Site Profiling of the Proteases ADAM10 and ADAM17 Using Proteome-Derived Peptide Libraries.
Neoplasms
Localization of tumour necrosis factor-alpha converting enzyme in normal human skin.
Neoplasms
Mechanisms Of Hypoxia-Induced Immune Escape In Cancer And Their Regulation By Nitric Oxide.
Neoplasms
Mesenchymal stem cells: "repair cells" that serve wounds and cancer?
Neoplasms
Metalloprotease inhibitor profiles of human ADAM8 in vitro and in cell-based assays.
Neoplasms
Metalloproteinases ADAM10 and ADAM17 Mediate Migration and Differentiation in Glioblastoma Sphere-Forming Cells.
Neoplasms
Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17.
Neoplasms
MicroRNA-655-3p functions as a tumor suppressor by regulating ADAM10 and ?-catenin pathway in Hepatocellular Carcinoma.
Neoplasms
miR-320a modulates cell growth and chemosensitivity via regulating ADAM10 in gastric cancer.
Neoplasms
miR-448 suppressed gastric cancer proliferation and invasion by regulating ADAM10.
Neoplasms
miR-449a inhibits proliferation and invasion by regulating ADAM10 in hepatocellular carcinoma.
Neoplasms
MiR-449a regulates the cell migration and invasion of human non-small cell lung carcinoma by targeting ADAM10.
Neoplasms
Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates.
Neoplasms
Modulation of Immune Responses by Platelet-Derived ADAM10.
Neoplasms
Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer.
Neoplasms
NKG2D Ligand Shedding in Response to Stress: Role of ADAM10.
Neoplasms
Noncanonical Activation of Notch1 Protein by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Controls Melanoma Cell Proliferation.
Neoplasms
Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer.
Neoplasms
Overexpression of A disintegrin and metalloprotease 10 promotes tumor proliferation, migration and poor prognosis in hypopharyngeal squamous cell carcinoma.
Neoplasms
Overexpression of tumour necrosis factor-alpha-converting enzyme in psoriasis.
Neoplasms
P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells.
Neoplasms
Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-?B Signaling Pathway in ApoE-/- Mice.
Neoplasms
Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells.
Neoplasms
Protease Cargo in Circulating Exosomes of Breast Cancer and Ovarian Cancer Patients
Neoplasms
Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer.
Neoplasms
Proteolytic release of the p75NTR intracellular domain by ADAM10 promotes metastasis and resistance to anoikis.
Neoplasms
Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality.
Neoplasms
Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells.
Neoplasms
Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential.
Neoplasms
Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins.
Neoplasms
Relationships between serum HER2 ECD, TIMP-1 and clinical outcomes in Taiwanese breast cancer.
Neoplasms
Role of ADAMs in cancer formation and progression.
Neoplasms
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.
Neoplasms
SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice.
Neoplasms
Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients.
Neoplasms
SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.
Neoplasms
Shedding of endogenous MHC class I-related chain molecules A and B (MICA and MICB) from different human tumor entities: Heterogeneous involvement of the a disintegrin and metalloproteases 10 and 17 (ADAM10 and ADAM17).
Neoplasms
Silencing ADAM10 inhibits the in vitro and in vivo growth of hepatocellular carcinoma cancer cells.
Neoplasms
Soluble CXCL16 promotes TNF-?-induced apoptosis in DLBCL via the AMAD10-NF-?B regulatory feedback loop.
Neoplasms
Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells.
Neoplasms
SRC fine-tunes ADAM10 shedding activity to promote pituitary adenoma cell progression.
Neoplasms
Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes.
Neoplasms
Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways.
Neoplasms
Synthesis and in vitro Evaluation of ADAM10 and ADAM17 Highly Selective Bioimaging Probes.
Neoplasms
Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes.
Neoplasms
Targeting ADAM10 in Cancer and Autoimmunity.
Neoplasms
Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma.
Neoplasms
Tetraspanin CD9 interacts with ?-secretase to enhance its oncogenic function in pancreatic cancer.
Neoplasms
The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: Novel drug targets with therapeutic potential?
Neoplasms
The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events.
Neoplasms
The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?
Neoplasms
The association of the expression of miR-122-5p and its target ADAM10 with human breast cancer.
Neoplasms
The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity.
Neoplasms
The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas.
Neoplasms
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.
Neoplasms
The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer.
Neoplasms
The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3.
Neoplasms
The metalloproteinase ADAM10 requires its activity to sustain surface expression.
Neoplasms
The metalloproteinase ADAM10: A useful therapeutic target?
Neoplasms
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.
Neoplasms
The role of ADAMs in disease pathophysiology.
Neoplasms
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
Neoplasms
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.
Neoplasms
The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.
Neoplasms
Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.
Neoplasms
TNF? drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.
Neoplasms
Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression.
Neoplasms
Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.
Neoplasms
Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells.
Neoplasms
Trop-2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis.
Neoplasms
Tspan5 promotes epithelial-mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling.
Neoplasms
TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS.
Neoplasms
Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10.
Neoplasms
Tumor necrosis factor-?-induced a disintegrin and metalloprotease 10 increases apoptosis resistance in prostate cancer cells.
Neoplasms
Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by ?-secretase complex.
Neoplasms
Tumor-associated MICA is shed by ADAM proteases.
Neoplasms
Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients.
Neoplasms
Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular carcinomas.
Neoplasms
Upregulation of the alpha-secretase ADAM10--risk or reason for hope?
Neoplasms
Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE.
Neoplasms
Vitamin D-induced ectodomain shedding of TNF receptor 1 as a nongenomic action: D3 vs D2 derivatives.
Neoplasms
[Generation and characterization of the adult neuron-specific ADAM10 knock-out mice].
Neoplasms
[miR-140-5p affects the migration and invasion of hypopharyngeal carcinoma cells by downregulating ADAM10 expression].
Nephritis
ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage.
Nephrotic Syndrome
oxLDL promotes podocyte migration by regulating CXCL16, ADAM10 and ACTN4.
Nervous System Diseases
Neuronal ADAM10 Promotes Outgrowth of Small-Caliber Myelinated Axons in the Peripheral Nervous System.
Nervous System Diseases
Regulation of ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.
Neuralgia
Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury-Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells.
Neuroblastoma
Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines.
Neuroblastoma
Acitretin, an Enhancer of Alpha-Secretase Expression, Crosses the Blood-Brain Barrier and Is Not Eliminated by P-Glycoprotein.
Neuroblastoma
ADAM10 expression and promoter haplotype in Alzheimer's disease.
Neuroblastoma
ADAM10 Plasma and CSF Levels Are Increased in Mild Alzheimer's Disease.
Neuroblastoma
ADAM9 inhibition increases membrane activity of ADAM10 and controls ?-secretase processing of amyloid precursor protein.
Neuroblastoma
Alpha-secretase as a therapeutic target.
Neuroblastoma
Chronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative alpha-secretases, ADAM10 and TACE, without altering their mRNA levels.
Neuroblastoma
Extract of Caragana sinica as a potential therapeutic option for increasing alpha-secretase gene expression.
Neuroblastoma
Phenanthroline impairs ?APP processing and expression, increases p53 protein levels and induces cell cycle arrest in human neuroblastoma cells.
Neuroblastoma
PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid.
Neuroblastoma
PKC Activation Counteracts ADAM10 Deficit in HuD-Silenced Neuroblastoma Cells.
Neuroblastoma
Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-? oligomers.
Neuroblastoma
Retinoids as a perspective in treatment of Alzheimer's disease.
Neuroblastoma
Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein.
Neuroblastoma
Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases.
Neuroblastoma
Stimulation of Non-Amyloidogenic Processing of Amyloid-? Protein Precursor by Cryptotanshinone Involves Activation and Translocation of ADAM10 and PKC-?
Neuroblastoma
Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
Neuroblastoma
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.
Neuroblastoma
The expression of the nicotinic acetylcholine receptor ?3 subunit in the brains of patients with Alzheimer's disease and its effects on ?- and ?-secretases and Notch signal transduction in SH-SY5Y cells.
Neuroblastoma
Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.
Neuroblastoma
Up-regulation of the {alpha}-secretase ADAM10 by retinoic acid receptors and acitretin.
Neurodegenerative Diseases
ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer's disease.
Neurodegenerative Diseases
Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer's Disease Treatment.
Neurodegenerative Diseases
Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence.
Neurodegenerative Diseases
LC-MS Based Cleavage Site Profiling of the Proteases ADAM10 and ADAM17 Using Proteome-Derived Peptide Libraries.
Neurodegenerative Diseases
PKC Activation Counteracts ADAM10 Deficit in HuD-Silenced Neuroblastoma Cells.
Neurodegenerative Diseases
Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms.
Neurodegenerative Diseases
Roles of endoproteolytic ?-cleavage and shedding of the prion protein in neurodegeneration.
Neurodegenerative Diseases
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.
Neurodegenerative Diseases
The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: Novel drug targets with therapeutic potential?
Neurodegenerative Diseases
Upregulation of the alpha-secretase ADAM10--risk or reason for hope?
Neuroinflammatory Diseases
ADAM10 suppresses demyelination and reduces seizure susceptibility in cuprizone-induced demyelination model.
Neuroinflammatory Diseases
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.
Neuroinflammatory Diseases
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
Neuroinflammatory Diseases
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation.
Neuroinflammatory Diseases
The Gut-Brain Axis in Autism Spectrum Disorder: A Focus on the Metalloproteases ADAM10 and ADAM17.
Nevus
PAX2 Regulates ADAM10 Expression and Mediates Anchorage-Independent Cell Growth of Melanoma Cells.
Obesity
The effect of age and obesity on platelet amyloid precursor protein processing and plasma markers of oxidative stress and inflammation.
Osteoarthritis
ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage.
Osteosarcoma
Aberrant ADAM10 expression correlates with osteosarcoma progression.
Osteosarcoma
ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/?-catenin signaling pathway and is regulated by miR-122-5p.
Ovarian Neoplasms
Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17.
Ovarian Neoplasms
Metalloproteinases at the surface of small extrcellular vesicles in advanced ovarian cancer: Relationships with ascites volume and peritoneal canceromatosis index.
Ovarian Neoplasms
Protease Cargo in Circulating Exosomes of Breast Cancer and Ovarian Cancer Patients
Ovarian Neoplasms
Proteases and their inhibitors as prognostic factors for high-grade serous ovarian cancer.
Pancreatic Neoplasms
A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding.
Pancreatic Neoplasms
ADAM10 Evens Out the Double-Edged Sword of Radiotherapy in Pancreatic Cancer.
Pancreatic Neoplasms
Expression of A disintegrin and metalloprotease 10 in pancreatic carcinoma.
Pancreatic Neoplasms
Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and ?-catenin signaling.
Pancreatic Neoplasms
Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer.
Pancreatitis, Chronic
Expression of A disintegrin and metalloprotease 10 in pancreatic carcinoma.
Parkinson Disease
Association of ADAM10 gene variants with sporadic Parkinson's disease in Chinese Han population.
Parkinson Disease
Cerebrospinal fluid A?42 levels and APP processing pathway genes in Parkinson's disease.
Pemphigus
The involvement of ADAM10 in mucocutaneous pemphigus vulgaris acantholysis depends on the autoantibody profile in each patient.
Pituitary Neoplasms
ADAM10 promotes pituitary adenoma cell migration by regulating cleavage of CD44 and L1.
Pituitary Neoplasms
SRC fine-tunes ADAM10 shedding activity to promote pituitary adenoma cell progression.
Pneumonia
A potential new target for asthma therapy: A Disintegrin and Metalloprotease 10 (ADAM10) involvement in murine experimental asthma.
Pneumonia
A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice.
Pneumonia
ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myeloid Cell Population.
Pneumonia
Tissue-specific patterning of host innate immune responses by Staphylococcus aureus ?-toxin.
Pneumonia, Staphylococcal
Immunopathogenesis of Staphylococcus aureus pulmonary infection.
Polycystic Kidney, Autosomal Dominant
Polycystin-1 and G?12 regulate the cleavage of E-cadherin in kidney epithelial cells.
Polymyositis
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
Polyuria
Adam10 Mediates the Choice between Principal Cells and Intercalated Cells in the Kidney.
Pre-Eclampsia
Increased ADAM10 expression in preeclamptic placentas is associated with decreased expression of hydrogen sulfide production enzymes.
Pre-Eclampsia
Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia.
Pre-Eclampsia
Protocadherin-12 cleavage is a regulated process mediated by ADAM-10. Evidence of shedding upregulation in preeclampsia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL.
Prion Diseases
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.
Prion Diseases
Shedding light on prion disease.
Prion Diseases
Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein.
Prion Diseases
The sheddase ADAM10 is a potent modulator of prion disease.
Prion Diseases
TREM2 expression in the brain and biological fluids in prion diseases.
Prostatic Hyperplasia
Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas.
Prostatic Neoplasms
Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP.
Prostatic Neoplasms
Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer.
Prostatic Neoplasms
Tumor necrosis factor-?-induced a disintegrin and metalloprotease 10 increases apoptosis resistance in prostate cancer cells.
Purpura Fulminans
An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans.
Purpura, Thrombocytopenic, Idiopathic
Increased ADAM10 expression in patients with immune thrombocytopenia.
Radiation Fibrosis Syndrome
ADAM10 Evens Out the Double-Edged Sword of Radiotherapy in Pancreatic Cancer.
Renal Insufficiency, Chronic
PAX2 may induce ADAM10 expression in renal tubular epithelial cells and contribute to epithelial-to-mesenchymal transition.
Renal Insufficiency, Chronic
Therapeutic impact of rHuEPO on abnormal platelet APP, BACE 1, presenilin 1, ADAM 10 and A? expressions in chronic kidney disease patients with cognitive dysfunction like Alzheimer's disease: A pilot study.
Reoviridae Infections
A functional role for ADAM10 in human immunodeficiency virus type-1 replication.
Retroviridae Infections
[miR-25-3p down-regulates the expression of ADAM10 to inhibit the differentiation of P19 cells into cardiomyocytes by blocking the Notch signaling pathway].
Rhinitis
Expression of ADAM17 and ADAM10 in nasal polyps.
Rhinitis, Allergic
Expression profile of ADAM10 and ADAM17 in allergic rhinitis.
Scrapie
Apparent Reduction of ADAM10 in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents.
Scrapie
Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo.
Seizures
ADAM10 suppresses demyelination and reduces seizure susceptibility in cuprizone-induced demyelination model.
Seizures
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.
Seizures
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation.
Seizures
Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.
Seizures
Promoter Variants of the ADAM10 Gene and Their Roles in Temporal Lobe Epilepsy.
Seizures
Regulation of ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.
Seizures
Stage-dependent involvement of ADAM10 and its significance in epileptic seizures.
Sepsis
A Functional Polymorphism-Mediated Disruption of EGR1/ADAM10 Pathway Confers the Risk of Sepsis Progression.
Sepsis
ADAM10 mediates vascular injury induced by Staphylococcus aureus ?-hemolysin.
Sepsis
An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis.
Sepsis
miR-23b Negatively Regulates Sepsis-Induced Inflammatory Responses by Targeting ADAM10 in Human THP-1 Monocytes.
Sepsis
Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis.
Sepsis
Synergistic Action of Staphylococcus aureus ?-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis.
Shock, Septic
Plasma soluble Tim-3 emerges as an inhibitor in sepsis: sepsis contrary to membrane Tim-3 on monocytes.
Squamous Cell Carcinoma of Head and Neck
Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
ADAM 10 is over expressed in oral squamous cell carcinoma and contributes to invasive behaviour through a functional association with ?v?6 integrin.
Squamous Cell Carcinoma of Head and Neck
Expression of ADAM10, Fas, FasL and Soluble FasL in Patients with Oral Squamous Cell Carcinoma (OSCC) and their Association with Clinical-Pathological Parameters.
Squamous Cell Carcinoma of Head and Neck
Overexpression of A disintegrin and metalloprotease 10 promotes tumor proliferation, migration and poor prognosis in hypopharyngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Overexpression of ADAM10 in oral squamous cell carcinoma with metastases.
Squamous Cell Carcinoma of Head and Neck
Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling.
Squamous Cell Carcinoma of Head and Neck
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding.
Squamous Cell Carcinoma of Head and Neck
Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation.
Squamous Cell Carcinoma of Head and Neck
Upregulation of ADAM10 in oral squamous cell carcinoma and its correlation with EGFR, neoangiogenesis and clinicopathologic factors.
Staphylococcal Infections
Tissue-specific patterning of host innate immune responses by Staphylococcus aureus ?-toxin.
Starvation
Autophagy-Dependent Increased ADAM10 Mature Protein Induced by TFEB Overexpression Is Mediated Through PPAR?.
Status Epilepticus
ADAM9, ADAM10, and ADAM15 mRNA levels in the rat brain after kainic acid-induced status epilepticus.
Status Epilepticus
Regulation of ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.
Stomach Neoplasms
ADAM 10 is associated with gastric cancer progression and prognosis of patients.
Stomach Neoplasms
ADAM-17 expression is enhanced by FoxM1 and is a poor prognostic sign in gastric carcinoma.
Stomach Neoplasms
EphA8 acts as an oncogene and contributes to poor prognosis in gastric cancer via regulation of ADAM10.
Stomach Neoplasms
miR-320a modulates cell growth and chemosensitivity via regulating ADAM10 in gastric cancer.
Stomach Neoplasms
miR-448 suppressed gastric cancer proliferation and invasion by regulating ADAM10.
Stroke
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.
Tauopathies
Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration.
Thromboangiitis Obliterans
ADAM10 inhibits the interaction between IL-17 and HMGB1 in Buerger's disease.
Thromboangiitis Obliterans
Alleviation of A disintegrin and metalloprotease 10 (ADAM10) on thromboangiitis obliterans involves the HMGB1/RAGE/ NF-?B pathway.
Thrombosis
Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular carcinomas.
Thyroid Neoplasms
Long Non-Coding RNA LUCAT1 Promotes Progression of Thyroid Carcinoma by Reinforcing ADAM10 Expression Through Sequestering microRNA-493.
Tongue Neoplasms
Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells.
Triple Negative Breast Neoplasms
ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPc.
Triple Negative Breast Neoplasms
miR-365 inhibits cell invasion and migration of triple negative breast cancer through ADAM10.
Triple Negative Breast Neoplasms
Proteolytic processing of PD-L1 by ADAM proteases in breast cancer cells.
Urinary Bladder Neoplasms
ADAM10 regulates proliferation, invasion, and chemoresistance of bladder cancer cells.
Uterine Cervical Neoplasms
LncRNA SNHG20 promotes cell proliferation and invasion via miR-140-5p-ADAM10 axis in cervical cancer.
Varicose Veins
Increased Levels of Metalloproteinase 10 and Hemostatic Markers in Patients With Noncomplicated Primary Varicose Veins.
Vascular Diseases
The Antiatherogenic Effect of Fish Oil in Male Mice Is Associated with a Diminished Release of Endothelial ADAM17 and ADAM10 Substrates.
Vascular System Injuries
ADAM10 mediates vascular injury induced by Staphylococcus aureus ?-hemolysin.
Virus Diseases
ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myeloid Cell Population.
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Vincent, B.; Paitel, E.; Saftig, P.; Frobert, Y.; Hartmann, D.; De Strooper, B.; Grassi, J.; Lopez-Perez, E.; Checler, F.
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein
J. Biol. Chem.
276
37743-37746
2001
Homo sapiens, Mus musculus
brenda
Lopez-Perez, E.; Zhang, Y.; Frank, S.J.; Creemers, J.; Seidah, N.; Checler, F.
Constitutive a-secretase cleavage of the b-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10
J. Neurochem.
76
1532-1539
2001
Homo sapiens
brenda
Anders, A.; Gilbert, S.; Garten, W.; Postina, R.; Fahrenholz, F.
Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases
FASEB J.
15
1837-1839
2001
Bos taurus, Homo sapiens
brenda
Lemjabbar, H.; Basbaum, C.
Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells
Nat. Med.
8
41-46
2002
Homo sapiens
brenda
Gutwein, P.; Mechtersheimer, S.; Riedle, S.; Stoeck, A.; Gast, D.; Joumaa, S.; Zentgraf, H.; Fogel, M.; Altevogt, P.
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles
FASEB J.
17
292-294
2003
Homo sapiens
brenda
Asai, M.; Hattori, C.; Szabo, B.; Sasagawa, N.; Maruyama, K.; Tanuma, S.I.; Ishiura, S.
Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase
Biochem. Biophys. Res. Commun.
301
231-235
2003
Homo sapiens
brenda
Gatta, L.B.; Albertini, A.; Ravid, R.; Finazzi, D.
Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus
NeuroReport
13
2031-2033
2002
Homo sapiens
brenda
Colciaghi, F.; Borroni, B.; Pastorino, L.; Marcello, E.; Zimmermann, M.; Cattabeni, F.; Padovani, A.; Di Luca, M.
alpha-secretase ADAM10 as well as aAPPs is reduced in platelets and CSF of Alzheimer Disease patients
Mol. Med.
8
67-74
2002
Homo sapiens
brenda
Yan, Y.; Shirakabe, K.; Werb, Z.
The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors
J. Cell Biol.
158
221-226
2002
Chlorocebus aethiops, Homo sapiens
brenda
Murai, T.; Miyauchi, T.; Yanagida, T.; Sako, Y.
Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10
Biochem. J.
395
65-71
2006
Homo sapiens
brenda
McCulloch, D.R.; Akl, P.; Samaratunga, H.; Herington, A.C.; Odorico, D.M.
Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP
Clin. Cancer Res.
10
314-323
2004
Homo sapiens
brenda
Ludwig, A.; Hundhausen, C.; Lambert, M.H.; Broadway, N.; Andrews, R.C.; Bickett, D.M.; Leesnitzer, M.A.; Becherer, J.D.
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules
Comb. Chem. High Throughput Screen.
8
161-171
2005
Homo sapiens
brenda
Allinson, T.M.; Parkin, E.T.; Condon, T.P.; Schwager, S.L.; Sturrock, E.D.; Turner, A.J.; Hooper, N.M.
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein
Eur. J. Biochem.
271
2539-2547
2004
Homo sapiens
brenda
Zimmermann, M.; Gardoni, F.; Marcello, E.; Colciaghi, F.; Borroni, B.; Padovani, A.; Cattabeni, F.; Di Luca, M.
Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines
J. Neurochem.
90
1489-1499
2004
Homo sapiens
brenda
Bandyopadhyay, S.; Hartley, D.M.; Cahill, C.M.; Lahiri, D.K.; Chattopadhyay, N.; Rogers, J.T.
Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase
J. Neurosci. Res.
84
106-118
2006
Homo sapiens
brenda
Uemura, K.; Kihara, T.; Kuzuya, A.; Okawa, K.; Nishimoto, T.; Ninomiya, H.; Sugimoto, H.; Kinoshita, A.; Shimohama, S.
Characterization of sequential N-cadherin cleavage by ADAM10 and PS1
Neurosci. Lett.
402
278-283
2006
Homo sapiens
brenda
Maretzky, T.; Reiss, K.; Ludwig, A.; Buchholz, J.; Scholz, F.; Proksch, E.; de Strooper, B.; Hartmann, D.; Saftig, P.
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation
Proc. Natl. Acad. Sci. USA
102
9182-9187
2005
Homo sapiens, Mus musculus
brenda
Schramme, A.; Abdel-Bakky, M.S.; Kaempfer-Kolb, N.; Pfeilschifter, J.; Gutwein, P.
The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells
Biochem. Biophys. Res. Commun.
370
311-316
2008
Homo sapiens
brenda
Ko, S.; Lin, S.; Wong, Y.; Liu, C.; Chang, K.; Liu, T.
Increase of disintegrin and metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma
Cancer Lett.
245
33-43
2007
Homo sapiens
brenda
Gavert, N.; Sheffer, M.; Raveh, S.; Spaderna, S.; Shtutman, M.; Brabletz, T.; Barany, F.; Paty, P.; Notterman, D.; Domany, E.; Ben-Zeev, A.
Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis
Cancer Res.
67
7703-7712
2007
Homo sapiens
brenda
Smith, C.; Halvorsen, B.; Otterdal, K.; Waehre, T.; Yndestad, A.; Fevang, B.; Sandberg, W.J.; Breland, U.M.; Froland, S.S.; Oie, E.; Gullestad, L.; Damas, J.K.; Aukrust, P.
High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins
Cardiovasc. Res.
79
195-203
2008
Homo sapiens
brenda
Schulte, M.; Reiss, K.; Lettau, M.; Maretzky, T.; Ludwig, A.; Hartmann, D.; de Strooper, B.; Janssen, O.; Saftig, P.
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death
Cell Death Differ.
14
1040-1049
2007
Homo sapiens
brenda
Conrad, D.H.; Ford, J.W.; Sturgill, J.L.; Gibb, D.R.
CD23: an overlooked regulator of allergic disease
Curr. Allergy Asthma Rep.
7
331-337
2007
Homo sapiens
brenda
Hakulinen, J.; Keski-Oja, J.
ADAM10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells
J. Biol. Chem.
281
21369-21376
2006
Homo sapiens
brenda
Lemieux, G.A.; Blumenkron, F.; Yeung, N.; Zhou, P.; Williams, J.; Grammer, A.C.; Petrovich, R.; Lipsky, P.E.; Moss, M.L.; Werb, Z.
The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10
J. Biol. Chem.
282
14836-14844
2007
Homo sapiens
brenda
Martin, L.; Fluhrer, R.; Reiss, K.; Kremmer, E.; Saftig, P.; Haass, C.
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b
J. Biol. Chem.
283
1644-1652
2008
Homo sapiens
brenda
Kaczur, V.; Puskas, L.G.; Nagy, Z.U.; Miled, N.; Rebai, A.; Juhasz, F.; Kupihar, Z.; Zvara, A.; Hackler, L.J.; Farid, N.R.
Cleavage of human thyrotropin receptor by ADAM10 is regulated by thyrotropin
J. Mol. Recognit.
20
392-404
2007
Homo sapiens (O14672), Homo sapiens
brenda
Dehmel, T.; Janke, A.; Hartung, H.P.; Goebel, H.H.; Wiendl, H.; Kieseier, B.C.
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies
Neurobiol. Dis.
25
665-674
2007
Homo sapiens
brenda
Chen, C.D.; Podvin, S.; Gillespie, E.; Leeman, S.E.; Abraham, C.R.
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
Proc. Natl. Acad. Sci. USA
104
19796-19801
2007
Homo sapiens
brenda
Rapti, M.; Atkinson, S.J.; Lee, M.H.; Trim, A.; Moss, M.; Murphy, G.
The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition
Biochem. J.
411
433-439
2008
Homo sapiens
brenda
Escrevente, C.; Morais, V.A.; Keller, S.; Soares, C.M.; Altevogt, P.; Costa, J.
Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme
Biochim. Biophys. Acta
1780
905-913
2008
Bos taurus, Homo sapiens
brenda
Esselens, C.W.; Malapeira, J.; Colome, N.; Moss, M.; Canals, F.; Arribas, J.
Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17
Biol. Chem.
389
1075-1084
2008
Homo sapiens
brenda
Schulz, B.; Pruessmeyer, J.; Maretzky, T.; Ludwig, A.; Blobel, C.P.; Saftig, P.; Reiss, K.
ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin
Circ. Res.
102
1192-1201
2008
Homo sapiens
brenda
Raucci, A.; Cugusi, S.; Antonelli, A.; Barabino, S.M.; Monti, L.; Bierhaus, A.; Reiss, K.; Saftig, P.; Bianchi, M.E.
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
FASEB J.
22
3716-3727
2008
Homo sapiens, Mus musculus
brenda
Freese, C.; Garratt, A.N.; Fahrenholz, F.; Endres, K.
The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1
FEBS J.
276
1568-1580
2009
Homo sapiens, Mus musculus
brenda
Oh, S.T.; Schramme, A.; Stark, A.; Tilgen, W.; Gutwein, P.; Reichrath, J.
The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas
J. Cutan. Pathol.
36
395-401
2009
Homo sapiens
brenda
Arduise, C.; Abache, T.; Li, L.; Billard, M.; Chabanon, A.; Ludwig, A.; Mauduit, P.; Boucheix, C.; Rubinstein, E.; Le Naour, F.
Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor
J. Immunol.
181
7002-7013
2008
Homo sapiens
brenda
Parkin, E.; Harris, B.
A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10
J. Neurochem.
108
1464-1479
2009
Homo sapiens
brenda
Dehmel, T.; Goebel, H.H.; Hartung, H.P.; Lehmann, H.; Wiendl, H.; Kieseier, B.C.
The metalloproteinase-disintegrin ADAM10 is exclusively expressed by type I muscle fibers
Muscle Nerve
38
1049-1051
2008
Homo sapiens
brenda
Qin, W.; Ho, L.; Wang, J.; Peskind, E.; Pasinetti, G.M.
S100A7, a novel Alzheimers disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10
PLoS ONE
4
e4183
2009
Homo sapiens
brenda
Riedle, S.; Kiefel, H.; Gast, D.; Bondong, S.; Wolterink, S.; Gutwein, P.; Altevogt, P.
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity
Biochem. J.
420
391-402
2009
Homo sapiens
brenda
Dittmer, A.; Hohlfeld, K.; Luetzkendorf, J.; Mueller, L.P.; Dittmer, J.
Human mesenchymal stem cells induce E-cadherin degradation in breast carcinoma spheroids by activating ADAM10
Cell. Mol. Life Sci.
66
3053-3065
2009
Homo sapiens
brenda
Oh, S.T.; Cho, B.K.; Schramme, A.; Gutwein, P.; Tilgen, W.; Reichrath, J.
Hair-cycle dependent differential expression of ADAM 10 and ADAM 12: An immunohistochemical analysis in human hair follicles in situ
Dermatoendocrinol.
1
46-53
2009
Homo sapiens
brenda
Tippmann, F.; Hundt, J.; Schneider, A.; Endres, K.; Fahrenholz, F.
Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin
FASEB J.
23
1643-1654
2009
Homo sapiens
brenda
Xu, D.; Sharma, C.; Hemler, M.E.
Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein
FASEB J.
23
3674-3681
2009
Homo sapiens
brenda
Endres, K.; Fahrenholz, F.
Upregulation of the alpha-secretase ADAM10--risk or reason for hope?
FEBS J.
277
1585-1596
2010
Homo sapiens, Mus musculus
brenda
Kim, M.; Suh, J.; Romano, D.; Truong, M.H.; Mullin, K.; Hooli, B.; Norton, D.; Tesco, G.; Elliott, K.; Wagner, S.L.; Moir, R.D.; Becker, K.D.; Tanzi, R.E.
Potential late-onset Alzheimers disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity
Hum. Mol. Genet.
18
3987-3996
2009
Homo sapiens
brenda
Peng, M.; Guo, S.; Yin, N.; Xue, J.; Shen, L.; Zhao, Q.; Zhang, W.
Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17
Immunology
130
83-91
2010
Homo sapiens
brenda
Ratchford, A.M.; Baker, O.J.; Camden, J.M.; Rikka, S.; Petris, M.J.; Seye, C.I.; Erb, L.; Weisman, G.A.
P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells
J. Biol. Chem.
285
7545-7555
2010
Homo sapiens
brenda
Jacobsen, K.T.; Adlerz, L.; Multhaup, G.; Iverfeldt, K.
Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases
J. Biol. Chem.
285
10223-10231
2010
Homo sapiens
brenda
Endres, K.; Fahrenholz, F.
Regulation of alpha-secretase ADAM10 expression and activity
Exp. Brain Res.
2011
1-10
2011
Homo sapiens
-
brenda
Bouillot, S.; Tillet, E.; Carmona, G.; Prandini, M.H.; Gauchez, A.S.; Hoffmann, P.; Alfaidy, N.; Cand, F.; Huber, P.
Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia
J. Biol. Chem.
286
15195-15204
2011
Homo sapiens
brenda
Blume, K.E.; Soeroes, S.; Keppeler, H.; Stevanovic, S.; Kretschmer, D.; Rautenberg, M.; Wesselborg, S.; Lauber, K.
Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic find-me signal
J. Immunol.
188
135-145
2012
Homo sapiens
brenda
Hogl, S.; Kuhn, P.H.; Colombo, A.; Lichtenthaler, S.F.
Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase
PLoS ONE
6
e21337
2011
Homo sapiens
brenda
Nagara, Y.; Hagiyama, M.; Hatano, N.; Futai, E.; Suo, S.; Takaoka, Y.; Murakami, Y.; Ito, A.; Ishiura, S.
Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by gamma-secretase complex
Biochem. Biophys. Res. Commun.
417
462-467
2012
Homo sapiens (O14672)
brenda
Pabois, A.; Devalliere, J.; Quillard, T.; Coulon, F.; Gerard, N.; Laboisse, C.; Toquet, C.; Charreau, B.
The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells
Biochem. Pharmacol.
91
510-521
2014
Homo sapiens (O14672), Homo sapiens
brenda
Breshears, L.M.; Schlievert, P.M.; Peterson, M.L.
A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1)
J. Biol. Chem.
287
32578-32587
2012
Homo sapiens (O14672), Homo sapiens
brenda
Minond, D.; Cudic, M.; Bionda, N.; Giulianotti, M.; Maida, L.; Houghten, R.; Fields, G.
Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates
J. Biol. Chem.
287
36473-36487
2012
Homo sapiens (O14672)
brenda
Hofmann, S.; Vgtle, T.; Bender, M.; Rose-John, S.; Nieswandt, B.
The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets
J. Thromb. Haemost.
10
2581-2592
2012
Homo sapiens (O14672), Mus musculus (O35598)
brenda
Shitomi, Y.; Thogersen, I.; Ito, N.; Leitinger, B.; Enghild, J.; Itoh, Y.
ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1)
Mol. Biol. Cell
26
659-673
2015
Homo sapiens (O14672)
brenda
Raikwar, N.; Liu, K.; Thomas, C.
N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain
PLoS ONE
9
e112794
2014
Homo sapiens (O14672)
brenda
Loreto, C.; Chiarenza, G.P.; Musumeci, G.; Castrogiovanni, P.; Imbesi, R.; Ruggeri, A.; Almeida, L.E.; Leonardi, R.
ADAM10 localization in temporomandibular joint disk with internal derangement an ex vivo immunohistochemical study
Acta Histochem.
118
293-298
2016
Homo sapiens
brenda
von Hoven, G.; Rivas, A.J.; Neukirch, C.; Klein, S.; Hamm, C.; Qin, Q.; Meyenburg, M.; Fueser, S.; Saftig, P.; Hellmann, N.; Postina, R.; Husmann, M.
Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus alpha-toxin action
Biochem. J.
473
1929-1940
2016
Homo sapiens (O14672), Homo sapiens
brenda
Pabois, A.; Devalliere, J.; Quillard, T.; Coulon, F.; Gerard, N.; Laboisse, C.; Toquet, C.; Charreau, B.
The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells
Biochem. Pharmacol.
91
510-521
2015
Homo sapiens (O14672), Homo sapiens
brenda
Vincent, B.
Regulation of the alpha-secretase ADAM10 at transcriptional, translational and post-translational levels
Brain Res. Bull.
126
154-169
2016
Homo sapiens (O14672)
brenda
You, B.; Shan, Y.; Shi, S.; Li, X.; You, Y.
Effects of ADAM10 upregulation on progression, migration, and prognosis of nasopharyngeal carcinoma
Cancer Sci.
106
1506-1514
2015
Homo sapiens (O14672), Homo sapiens
brenda
Endres, K.; Deller, T.
Regulation of alpha-secretase ADAM10 in vitro and in vivo Genetic, epigenetic, and protein-based mechanisms
Front. Mol. Neurosci.
10
56
2017
Homo sapiens (O14672), Homo sapiens
brenda
Siney, E.J.; Holden, A.; Casselden, E.; Bulstrode, H.; Thomas, G.J.; Willaime-Morawek, S.
Metalloproteinases ADAM10 and ADAM17 mediate migration and differentiation in glioblastoma sphere-forming cells
Mol. Neurobiol.
54
3893-3905
2017
Homo sapiens (O14672), Homo sapiens
brenda
Madoux, F.; Dreymuller, D.; Pettiloud, J.P.; Santos, R.; Becker-Pauly, C.; Ludwig, A.; Fields, G.B.; Bannister, T.; Spicer, T.P.; Cudic, M.; Scampavia, L.D.; Minond, D.
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate
Sci. Rep.
6
11
2016
Homo sapiens (O14672)
brenda
Riethmueller, S.; Ehlers, J.C.; Lokau, J.; Duesterhoeft, S.; Knittler, K.; Dombrowsky, G.; Groetzinger, J.; Rabe, B.; Rose-John, S.; Garbers, C.
Cleavage site localization differentially controls interleukin-6 receptor proteolysis by ADAM10 and ADAM17
Sci. Rep.
6
25550
2016
Homo sapiens (O14672)
brenda
Folkesson, M.; Li, C.; Frebelius, S.; Swedenborg, J.; Wagsaeter, D.; Williams, K.J.; Eriksson, P.; Roy, J.; Liu, M.L.
Proteolytically active ADAM10 and ADAM17 carried on membrane microvesicles in human abdominal aortic aneurysms
Thromb. Haemost.
114
1165-1174
2015
Homo sapiens
brenda