Reference on EC 3.4.24.79 - pappalysin-1
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lawrence, J.B.; Oxvig, C.; Overgaard, M.T.; Sottrup-Jensen, L.; Gleich, G.J.; Hays L.G.; Yates, J.R.3rd; Conover, C.A.
The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A
Proc. Natl. Acad. Sci. USA
96
3149-3153
1999
Homo sapiens (Q13219), Homo sapiens
Chen, B.K.; Overgaard, M.T.; Bale, L.K.; Resch, Z.T.; Christiansen, M.; Oxvig, C.; Conover, C.A.
Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: identification of a novel inducible inhibitor
Endocrinology
143
1199-1205
2002
Homo sapiens (Q13219), Homo sapiens
Lawrence, J.B.; Bale, L.K.; Haddad, T.C.; Clarkson, J.T.; Conover, C.A.
Characterization and partial purification of the insulin-like growth factor (IGF)-dependent IGF binding protein-4-specific protease from human fibroblast conditioned media
Growth Horm. IGF Res.
9
25-34
1999
Homo sapiens
Chelius, D.; Conover, C.A.; Baldwin, M.A.; Spencer, E.M.
Characterization of the enzymatic specificity of the IGF-dependent insulin-like growth factor binding protein-4 (IGFBP-4) protease
Growth Horm. IGF Res.
10
360-366
2000
Homo sapiens
Laursen, L.S.; Overgaard, M.T.; Soe, R.; Boldt, H.B.; Sottrup-Jensen, L.; Giudice, L.C.; Conover, C.A.; Oxvig, C.
Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A
FEBS Lett.
504
36-40
2001
Homo sapiens
Conover, C.A.; Durham, S.K.; Zapf, J.; Masiarz, F.R.; Kiefer, M.C.
Cleavage analysis of insulin-like growth factor (IGF)-dependent IGF-binding protein-4 proteolysis and expression of protease-resistant IGF-binding protein-4 mutants
J. Biol. Chem.
270
4395-4400
1995
Homo sapiens
Qin, X.; Byun, D.; Lau, K.H.W.; Baylink, D.J.; Mohan, S.
Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease
Arch. Biochem. Biophys.
379
209-216
2000
Homo sapiens
Laursen, L.S.; Overgaard, M.T.; Weyer, K.; Boldt, H.B.; Ebbesen, P.; Christiansen, M.; Sottrup-Jensen, L.; Giudice, L.C.; Oxvig, C.
Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity
J. Biol. Chem.
277
47225-47234
2002
Homo sapiens
Sun, I.Y.C.; Overgaard, M.T.; Oxvig, C.; Giudice, L.C.
Pregnancy-associated plasma protein A proteolytic activity is associated with the human placental trophoblast cell membrane
J. Clin. Endocrinol. Metab.
87
5235-5240
2002
Homo sapiens
Giudice, L.C.; Conover, C.A.; Bale, L.; Faessen, G.H.; Ilg, K.; Sun, I.; Imani, B.; Suen, L.F.; Irwin, J.C.; Christiansen, M.; Overgaard, M.T.; Oxvig, C.
Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: Evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation
J. Clin. Endocrinol. Metab.
87
2359-2366
2002
Homo sapiens
Byun, D.; Mohan, S.; Yoo, M.; Sexton, C.; Baylink, D.J.; Qin, X.
Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro
J. Clin. Endocrinol. Metab.
86
847-854
2001
Homo sapiens
Rivera, G.M.; Fortune, J.E.
Selection of the dominant follicle and insulin-like growth factor (IGF)-binding proteins: Evidence that pregnancy-associated plasma protein A contributes to proteolysis of IGF-binding protein 5 in bovine follicular fluid
Endocrinology
144
437-446
2003
Bos taurus
Mazerbourg, S.; Overgaard, M.T.; Oxvig, C.; Christiansen, M.; Conover, C.A.; Laurendeau, I.; Vidaud, M.; Tosser-Klopp, G.; Zapf, J.; Monget, P.
Pregnancy-associated plasma protein-A (PAPP-A) in ovine, bovine, porcine, and equine ovarian follicles: involvement in IGF binding protein-4 proteolytic degradation and mRNA expression during follicular development
Endocrinology
142
5243-5253
2001
Bos taurus, Equus caballus, Ovis ammon, Sus scrofa
Smith, E.P.; Kamyar, A.; Niu, W.; Wang, J.; Cercek, B.; Chernausek, S.D.; Fagin, J.A.
IGF-binding protein-4 expression and IGF-binding protein-4 protease activity are regulated coordinately in smooth muscle during postnatal development and after vascular injury
Endocrinology
142
4420-4427
2001
Rattus norvegicus
Miyakoshi, N.; Qin, X.; Kasukawa, Y.; Richman, C.; Srivastava, A.K.; Baylink, D.J.; Mohan, S.
Systemic administration of insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent mechanism
Endocrinology
142
2641-2648
2001
Mus musculus
Parker, A.; Gockerman, A.; Busby, W.H.; Clemmons, D.R.
Properties of an insulin-like growth factor-binding protein-4 protease that is secreted by smooth muscle cells
Endocrinology
136
2470-2476
1995
Sus scrofa
Conover, C.A.; Harrington, S.C.; Bale, L.K.; Oxvig, C.
Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages
Am. J. Physiol. Heart Circ. Physiol.
292
H994-H1000
2007
Homo sapiens
Gyrup, C.; Oxvig, C.
Quantitative analysis of insulin-like growth factor-modulated proteolysis of insulin-like growth factor binding protein-4 and -5 by pregnancy-associated plasma protein-A
Biochemistry
46
1972-1980
2007
Homo sapiens
Iversen, K.K.; Teisner, A.S.; Teisner, B.; Kliem, A.; Bay, M.; Kirk, V.; Nielsen, H.; Boesgaard, S.; Grande, P.; Clemmensen, P.
Pregnancy-associated plasma protein A in non-cardiac conditions
Clin. Biochem.
41
548-553
2008
Homo sapiens
Mueller, T.; Dieplinger, B.; Poelz, W.; Haltmayer, M.
Increased pregnancy-associated plasma protein-A as a marker for peripheral atherosclerosis: results from the Linz Peripheral Arterial Disease Study
Clin. Chem.
52
1096-1103
2006
Homo sapiens
Consuegra-Sanchez, L.; Petrovic, I.; Cosin-Sales, J.; Holt, D.W.; Christiansen, M.; Kaski, J.C.
Prognostic value of circulating pregnancy-associated plasma protein-A (PAPP-A) and proform of eosinophil major basic protein (pro-MBP) levels in patients with chronic stable angina pectoris
Clin. Chim. Acta
391
18-23
2008
Homo sapiens
Qin, X.; Wergedal, J.E.; Rehage, M.; Tran, K.; Newton, J.; Lam, P.; Baylink, D.J.; Mohan, S.
Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo
Endocrinology
147
5653-5661
2006
Homo sapiens
Rehage, M.; Mohan, S.; Wergedal, J.E.; Bonafede, B.; Tran, K.; Hou, D.; Phang, D.; Kumar, A.; Qin, X.
Transgenic overexpression of pregnancy-associated plasma protein-A increases the somatic growth and skeletal muscle mass in mice
Endocrinology
148
6176-6185
2007
Homo sapiens
Boldt, H.B.; Conover, C.A.
Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs
Growth Horm. IGF Res.
17
10-18
2007
Danio rerio, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes, Xenopus laevis, Tetraodon nigroviridis
Glerup, S.; Kloeverpris, S.; Laursen, L.S.; Dagnaes-Hansen, F.; Thiel, S.; Conover, C.A.; Oxvig, C.
Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor
J. Biol. Chem.
282
1769-1778
2007
Homo sapiens
Mikkelsen, J.H.; Gyrup, C.; Kristensen, P.; Overgaard, M.T.; Poulsen, C.B.; Laursen, L.S.; Oxvig, C.
Selective inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding
J. Biol. Chem.
283
16772-16780
2008
Homo sapiens
Miller, B.S.; Bronk, J.T.; Nishiyama, T.; Yamagiwa, H.; Srivastava, A.; Bolander, M.E.; Conover, C.A.
Pregnancy associated plasma protein-A is necessary for expeditious fracture healing in mice
J. Endocrinol.
192
505-513
2007
Mus musculus
Sudo, N.; Shimizu, T.; Kawashima, C.; Kaneko, E.; Tetsuka, M.; Miyamoto, A.
Insulin-like growth factor-I (IGF-I) system during follicle development in the bovine ovary: relationship among IGF-I, type 1 IGF receptor (IGFR-1) and pregnancy-associated plasma protein-A (PAPP-A)
Mol. Cell. Endocrinol.
264
197-203
2007
Bos taurus
Hajek, P.; Macek, M.; Hladikova, M.; Houbova, B.; Alan, D.; Durdil, V.; Fiedler, J.; Maly, M.; Ostadal, P.; Veselka, J.; Krebsova, A.
Pregnancy-associated plasma protein A and proform eosinophilic major basic protein in the detection of different types of coronary artery disease
Physiol. Res.
57
23-32
2008
Homo sapiens
Boldt, H.B.; Glerup, S.; Overgaard, M.T.; Sottrup-Jensen, L.; Oxvig, C.
Definition, expression, and characterization of a protein domain in the N-terminus of pregnancy-associated plasma protein-A distantly related to the family of laminin G-like modules
Protein Expr. Purif.
48
261-273
2006
Homo sapiens
Prinzen, C.; Truembach, D.; Wurst, W.; Endres, K.; Postina, R.; Fahrenholz, F.
Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
BMC Genomics
10
66
2009
Homo sapiens, Mus musculus
Joaquin, C.; Aguilera, E.; Granada, M.L.; Pastor, M.C.; Salinas, I.; Alonso, N.; Sanmarti, A.
Effects of GH treatment in GH-deficient adults on adiponectin, leptin and pregnancy-associated plasma protein-A
Eur. J. Endocrinol.
158
483-490
2008
Homo sapiens
Pellitero, S.; Reverter, J.; Granada, M.L.; Pizarro, E.; Pastor, M.C.; Tassies, D.; Reverter, J.C.; Salinas, I.; Sanmarti, A.
Association of the insulin-growth factor-1 (IGF-1)/pregnancy-associated plasma protein-A (PAPP-A) system and adipocytokine levels with the presence and the morphology of carotid plaques in type 2 diabetes mellitus patients with stable glycemic control
Eur. J. Endocrinol.
160
925-932
2009
Homo sapiens
Kagan, K.O.; Wright, D.; Valencia, C.; Maiz, N.; Nicolaides, K.H.
Screening for trisomies 21, 18 and 13 by maternal age, fetal nuchal translucency, fetal heart rate, free beta-hCG and pregnancy-associated plasma protein-A
Hum. Reprod.
23
1968-1975
2008
Homo sapiens
Amor, D.J.; Xu, J.X.; Halliday, J.L.; Francis, I.; Healy, D.L.; Breheny, S.; Baker, H.W.; Jaques, A.M.
Pregnancies conceived using assisted reproductive technologies (ART) have low levels of pregnancy-associated plasma protein-A (PAPP-A) leading to a high rate of false-positive results in first trimester screening for Down syndrome
Hum. Reprod.
24
1330-1338
2009
Homo sapiens
Conover, C.A.; Mason, M.A.; Levine, J.A.; Novak, C.M.
Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype
J. Endocrinol.
198
599-605
2008
Mus musculus
Bestwick, J.P.; Huttly, W.J.; Wald, N.J.
First trimester Downs syndrome screening marker values and cigarette smoking: new data and a meta-analysis on free beta human chorionic gonadotophin, pregnancy-associated plasma protein-A and nuchal translucency
J. Med. Screen.
15
204-206
2008
Homo sapiens
Deveci, K.; Sogut, E.; Evliyaoglu, O.; Duras, N.
Pregnancy-associated plasma protein-A and C-reactive protein levels in pre-eclamptic and normotensive pregnant women at third trimester
J. Obstet. Gynaecol. Res.
35
94-98
2009
Homo sapiens
Nishizawa, H.; Pryor-Koishi, K.; Suzuki, M.; Kato, T.; Kogo, H.; Sekiya, T.; Kurahashi, H.; Udagawa, Y.
Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients
Mol. Hum. Reprod.
14
595-602
2008
Homo sapiens
Pihl, K.; Larsen, T.; Krebs, L.; Christiansen, M.
First trimester maternal serum PAPP-A, beta-hCG and ADAM12 in prediction of small-for-gestational-age fetuses
Prenat. Diagn.
28
1131-1135
2008
Homo sapiens
Kagan, K.O.; Wright, D.; Spencer, K.; Molina, F.S.; Nicolaides, K.H.
First-trimester screening for trisomy 21 by free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A: impact of maternal and pregnancy characteristics
Ultrasound Obstet. Gynecol.
31
493-502
2008
Homo sapiens
Kagan, K.O.; Wright, D.; Baker, A.; Sahota, D.; Nicolaides, K.H.
Screening for trisomy 21 by maternal age, fetal nuchal translucency thickness, free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A
Ultrasound Obstet. Gynecol.
31
618-624
2008
Homo sapiens
Conover, C.A.; Mason, M.A.; Bale, L.K.; Harrington, S.C.; Nyegaard, M.; Oxvig, C.; Overgaard, M.T.
Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development
Am. J. Physiol. Heart Circ. Physiol.
299
H284-H291
2010
Homo sapiens (Q13219), Homo sapiens
Wittfooth, S.; Tertti, R.; Lepaentalo, M.; Porela, P.; Qin, Q.P.; Tynjaelae, J.; Inkinen, O.; Perttilae, J.; Airaksinen, K.E.; Pettersson, K.
Studies on the effects of heparin products on pregnancy-associated plasma protein A
Clin. Chim. Acta
412
376-381
2011
Homo sapiens (Q13219), Homo sapiens
Boldt, H.B.; Conover, C.A.
Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo
Endocrinology
152
1470-1478
2011
Homo sapiens (Q13219), Homo sapiens
Gaidamauskas, E.; Gyrup, C.; Boldt, H.; Schack, V.; Overgaard, M.; Laursen, L.; Oxvig, C.
IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): Multiple PAPP-A-IGFBP interaction sites
Biochim. Biophys. Acta
1830
2701-2709
2013
Homo sapiens (Q13219)
Jespersen, C.; Vestergaard, K.; Schou, M.; Teisner, B.; Iversen, K.
The effect of heparin on pregnancy associated plasma protein-A concentration in healthy, non-pregnant individuals
Clin. Biochem.
48
75
2015
Homo sapiens (Q13219), Homo sapiens
Delia, P.; Marzioni, D.; Castellucci, M.; Mocci, C.; Pala, A.
Homodimeric pregnancy-associated plasma protein-A in normal human placenta of first and third trimester of pregnancy: Biochemical and morphological observations
Placenta
33
942-945
2012
Homo sapiens (Q13219), Homo sapiens
Pan, H.; Hanada, S.; Zhao, J.; Mao, L.; Ma, M.
Protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth in vivo
PLoS ONE
7
e48799
2012
Homo sapiens (Q13219)
Conover, C.
Key questions and answers about pregnancy-associated plasma protein-A
Trends Endocrinol. Metab.
23
242-249
2012
Homo sapiens (Q13219)
Harstad, S.; Conover, C.
Tissue-specific changes in pregnancy associated plasma protein-A expression with age in mice
Exp. Gerontol.
57
13-17
2014
Mus musculus (Q8R4K8)
Jepsen, M.R.; Kloverpris, S.; Botkjaer, J.A.; Wissing, M.L.; Andersen, C.Y.; Oxvig, C.
The proteolytic activity of pregnancy-associated plasma protein-A is potentially regulated by stanniocalcin-1 and -2 during human ovarian follicle development
Hum. Reprod.
31
866-874
2016
Homo sapiens (Q13219), Homo sapiens
Kloverpris, S.; Mikkelsen, J.H.; Pedersen, J.H.; Jepsen, M.R.; Laursen, L.S.; Petersen, S.V.; Oxvig, C.
Stanniocalcin-1 potently inhibits the proteolytic activity of the metalloproteinase pregnancy-associated plasma protein-A
J. Biol. Chem.
290
21915-21924
2015
Homo sapiens (Q13219)
Espelund, U.S.; Bjerre, M.; Hjortebjerg, R.; Rasmussen, T.R.; Lundby, A.; Hoeflich, A.; Folkersen, B.H.; Oxvig, C.; Frystyk, J.
Insulin-like growth factor bioactivity, stanniocalcin-2, pregnancy-associated plasma protein-A, and IGF-binding protein-4 in pleural fluid and serum from patients with pulmonary disease
J. Clin. Endocrinol. Metab.
102
3526-3534
2017
Homo sapiens (Q13219), Homo sapiens
Cirillo, P.; Conte, S.; Pellegrino, G.; Ziviello, F.; Barra, G.; De Palma, R.; Leonardi, A.; Trimarco, B.
Pregnancy-associated plasma protein-A promotes TF procoagulant activity in human endothelial cells by Akt-NF-kappaB axis
J. Thromb. Thrombolysis
42
225-232
2016
Homo sapiens (Q13219), Homo sapiens
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