Information on EC 3.4.24.76 - flavastacin

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The expected taxonomic range for this enzyme is: Elizabethkingia meningoseptica

EC NUMBER
COMMENTARY hide
3.4.24.76
-
RECOMMENDED NAME
GeneOntology No.
flavastacin
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydrolyses polypeptides on the amino-side of Asp in -Xaa-/-Asp-. Acts very slowly on -Xaa-/-Glu
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
167973-66-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dansyl-Leu-(CHO)Asn-Asp-Ser-Arg-Val + H2O
dansyl-Leu-(CHO)Asn + Asp-Ser-Arg-Val
show the reaction diagram
-
-
-
?
furylacryloyl-Leu-Ala-Asp-Ala-Ala-NH2 + H2O
furylacryloyl-Leu-Ala + Asp-Ala-Ala-NH2
show the reaction diagram
-
-
-
-
?
furylacryloyl-Leu-Ala-Asp-Ala-Ser-NH2 + H2O
furylacryloyl-Leu-Ala + Asp-Ser-Ala-NH2
show the reaction diagram
additional information
?
-
-
aspargine and glutamine analogs not hydrolyzed, at high enzyme concentrations slow cleavage of the glutamic acid analog
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Zinc
-
zinc metalloendoprotease
Zn2+
-
activation accomplished by dialysis against 1 mM zinc acetate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
side-chain modification
-
O-linked heptasaccharide attached to Ser264 containing uronic acids and methylated sugars
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
to homogeneity by hydrophobic interaction chromatography in the presence of 10 mM EDTA to avoid autoproteolysis
-
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE