Reference on EC 3.4.24.74 - fragilysin
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kling, J.J.; Wright, R.L.; Moncrief, J.S.; Wilkins, T.D.
Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis
FEMS Microbiol. Lett.
146
279-284
1997
Bacteroides fragilis
Moncrief, J.S.; Obisco, R.; Barroso, L.A.; Kling, J.J.; Wright, R.L.; van Tassell, R.L.; Lyerly, D.M.; Wilkins, T.D.
The enterotoxin of Bacteroides fragilis is a metalloprotease
Infect. Immun.
63
175-181
1995
Bacteroides fragilis
Obisco, R.J.; Lyerly, D.M.; van Tassell, R.L.; Wilkins, R.D.
Proteolytic activity of Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo
Infect. Immun.
63
3820-3826
1995
Bacteroides fragilis
Obisco, R.J.; Bevan, D.R.; Wilkins, T.D.
Molecular modeling and analysis of fragilysin, the Bacteroides fragilis toxin
Clin. Infect. Dis.
25
S153-155
1997
Bacteroides fragilis
Mundy, L.M.; Sears, C.L.
Detection of toxin production by Bacteroides fragilis: assay development and screening of extraintestinal clinical isolates
Clin. Infect. Dis.
23
269-276
1996
Bacteroides fragilis
Moncrief, J.S.; Duncan, A.J.; Wright, R.L.; Barroso, L.A.; Wilkins, T.D.
Molecular characterization of the fragilysin pathogenicity islet of enterotoxigenic Bacteroides fragilis
Infect. Immun.
66
1735-1739
1998
Bacteroides fragilis
Obisco, R.J.; Azghani, A.O.; Wilkins, T.D.
The Bacteroides fragilis toxin fragilysin disrupts the paracellular barrier of epitheliar cells
Infect. Immun.
65
1431-1439
1997
Bacteroides fragilis
Van Tassell, R.L.; Lyerly, D.M.; Wilkins, T.D.
Purification and characterization of an enterotoxin from Bacteroides fragilis
Infect. Immun.
60
1343-1350
1992
Bacteroides fragilis
Donelli, G.; Fabbri, A.; Florentini, C.
Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells
Infect. Immun.
64
113-119
1996
Bacteroides fragilis
Kato, N.; Liu, C.X.; Kato, H.; Watanabe, K.; Tanaka, Y.; Yamamoto, T.; Suzuki, K.; Ueno, K.
A new subtype of the metalloprotease toxin gene and the incidence of the three bft subtypes among Bacteroides fragilis isolates in Japan
FEMS Microbiol. Lett.
182
171-176
2000
Bacteroides fragilis
Chung, G.T.; Franco, A.A.; Wu, S.; Rhie, G.E.; Cheng, R.; Oh, H.B.; Sears, C.L.
Identification of a third metalloprotease toxin gene in extraintestinal isolates of Bacteroides fragilis
Infect. Immun.
67
4945-4949
1999
Bacteroides fragilis (O86049), Bacteroides fragilis
Wu, S.; Dreyfus, L.A.; Tzianabos, A.O.; Hayashi, C.; Sears, C.L.
Diversity of the metalloprotease toxin produced by enterotoxigenic Bacteroides fragilis
Infect. Immun.
70
2463-2471
2002
Bacteroides fragilis
Ulger Toprak, N.; Rajendram, D.; Yagci, A.; Gharbia, S.; Shah, H.N.; Gulluoglu, B.M.; Akin, L.M.; Demirkalem, P.; Celenk, T.; Soyletir, G.
The distribution of the bft alleles among enterotoxigenic Bacteroides fragilis strains from stool specimens and extraintestinal sites
Anaerobe
12
71-74
2006
Bacteroides fragilis, Bacteroides fragilis NCTC 11295
Vines, R.R.; Wilkins, T.D.
Fragilysin
Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
588-591
2004
Bacteroides fragilis
-
Wu, S.; Powell, J.; Mathioudakis, N.; Kane, S.; Fernandez, E.; Sears, C.L.
Bacteroides fragilis enterotoxin induces intestinal epithelial cell secretion of interleukin-8 through mitogen-activated protein kinases and a tyrosine kinase-regulated nuclear factor-kappaB pathway
Infect. Immun.
72
5832-5839
2004
Bacteroides fragilis, Bacteroides fragilis 086-5443-2-2
Franco, A.A.; Buckwold, S.L.; Shin, J.W.; Ascon, M.; Sears, C.L.
Mutation of the zinc-binding metalloprotease motif affects Bacteroides fragilis toxin activity but does not affect propeptide processing
Infect. Immun.
73
5273-5277
2005
Bacteroides fragilis
Wu, S.; Shin, J.; Zhang, G.; Cohen, M.; Franco, A.; Sears, C.L.
The Bacteroides fragilis toxin binds to a specific intestinal epithelial cell receptor
Infect. Immun.
74
5382-5390
2006
Bacteroides fragilis, Bacteroides fragilis I-1345
Sears, C.L.; Buckwold, S.L.; Shin, J.W.; Franco, A.A.
The C-terminal region of Bacteroides fragilis toxin is essential to its biological activity
Infect. Immun.
74
5595-5601
2006
Bacteroides fragilis
Holton, J.
Enterotoxigenic Bacteroides fragilis
Curr. Infect. Dis. Rep.
10
99-104
2008
Bacteroides fragilis (O05091), Bacteroides fragilis (O86049), Bacteroides fragilis (Q9S5W0), Bacteroides fragilis
Almeida, F.S.; Nakano, V.; Avila-Campos, M.J.
Occurrence of enterotoxigenic and nonenterotoxigenic Bacteroides fragilis in calves and evaluation of their antimicrobial susceptibility
FEMS Microbiol. Lett.
272
15-21
2007
Bacteroides fragilis
Kim, J.M.; Lee, D.H.; Kim, J.S.; Lee, J.Y.; Park, H.G.; Kim, Y.J.; Oh, Y.K.; Jung, H.C.; Kim, S.I.
5,7-dihydroxy-3,4,6-trimethoxyflavone inhibits the inflammatory effects induced by Bacteroides fragilis enterotoxin via dissociating the complex of heat shock protein 90 and I kappaB alpha and I kappaB kinase-gamma in intestinal epithelial cell culture
Clin. Exp. Immunol.
155
541-551
2009
Bacteroides fragilis
Kim, J.M.; Lee, J.Y.; Kim, Y.J.
Inhibition of apoptosis in Bacteroides fragilis enterotoxin-stimulated intestinal epithelial cells through the induction of c-IAP-2
Eur. J. Immunol.
38
2190-2199
2008
Bacteroides fragilis
Rhee, K.J.; Wu, S.; Wu, X.; Huso, D.L.; Karim, B.; Franco, A.A.; Rabizadeh, S.; Golub, J.E.; Mathews, L.E.; Shin, J.; Sartor, R.B.; Golenbock, D.; Hamad, A.R.; Gan, C.M.; Housseau, F.; Sears, C.L.
Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice
Infect. Immun.
77
1708-1718
2009
Bacteroides fragilis
Yoon, Y.M.; Lee, J.Y.; Yoo, D.; Sim, Y.S.; Kim, Y.J.; Oh, Y.K.; Kang, J.S.; Kim, S.; Kim, J.S.; Kim, J.M.
Bacteroides fragilis enterotoxin induces human beta-defensin-2 expression in intestinal epithelial cells via a mitogen-activated protein kinase/I kappaB kinase/NF-kappaB-dependent pathway
Infect. Immun.
78
2024-2033
2010
Bacteroides fragilis
Roh, H.C.; Yoo, d.o..Y.; Ko, S.H.; Kim, Y.J.; Kim, J.M.
Bacteroides fragilis enterotoxin upregulates intercellular adhesion molecule-1 in endothelial cells via an aldose reductase-, MAPK-, and NF-kappaB-dependent pathway, leading to monocyte adhesion to endothelial cells
J. Immunol.
187
1931-1941
2011
Bacteroides fragilis
Goodwin, A.C.; Destefano Shields, C.E.; Wu, S.; Huso, D.L.; Wu, X.; Murray-Stewart, T.R.; Hacker-Prietz, A.; Rabizadeh, S.; Woster, P.M.; Sears, C.L.; Casero, R.A.
Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis
Proc. Natl. Acad. Sci. USA
108
15354-15359
2011
Bacteroides fragilis, Bacteroides fragilis 86-5443-2-2
Goulas, T.; Arolas, J.L.; Gomis-Rueth, F.X.
Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog
Proc. Natl. Acad. Sci. USA
108
1856-1861
2011
Bacteroides fragilis (O86049), Bacteroides fragilis
Kharlampieva, D.; Manuvera, V.; Podgorny, O.; Kovalchuk, S.; Pobeguts, O.; Altukhov, I.; Alexeev, D.; Lazarev, V.; Govorun, V.
Purification and characterisation of recombinant Bacteroides fragilis toxin-2
Biochimie
95
2123-2131
2013
Bacteroides fragilis
Shiryaev, S.; Aleshin, A.; Muranaka, N.; Kukreja, M.; Routenberg, D.; Remacle, A.; Liddington, R.; Cieplak, P.; Kozlov, I.; Strongin, A.
Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island
FEBS J.
281
2487-2502
2014
Bacteroides fragilis (O86049), Bacteroides fragilis
Shiryaev, S.; Remacle, A.; Chernov, A.; Golubkov, V.; Motamedchaboki, K.; Muranaka, N.; Dambacher, C.; Capek, P.; Kukreja, M.; Kozlov, I.; Perucho, M.; Cieplak, P.; Strongin, A.
Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface
J. Biol. Chem.
288
34956-34967
2013
Bacteroides fragilis (O86049), Bacteroides fragilis
Yoo, D.; Ko, S.; Jung, J.; Kim, Y.; Kim, J.; Kim, J.
Bacteroides fragilis enterotoxin upregulates lipocalin-2 expression in intestinal epithelial cells
Lab. Invest.
93
384-396
2013
Bacteroides fragilis (O86049), Bacteroides fragilis
Kharlampieva, D.; Manuvera, V.; Podgorny, O.; Grafskaia, E.; Kovalchuk, S.; Pobeguts, O.; Altukhov, I.; Govorun, V.; Lazarev, V.
Recombinant fragilysin isoforms cause E-cadherin cleavage of intact cells and do not cleave isolated E-cadherin
Microb. Pathog.
83-84
47-56
2015
Bacteroides fragilis (O86049), Bacteroides fragilis
Herrou, J.; Choi, V.M.; Bubeck Wardenburg, J.; Crosson, S.
Activation Mechanism of the Bacteroides fragilis cysteine peptidase, fragipain
Biochemistry
55
4077-4084
2016
Bacteroides fragilis
Zakharzhevskaya, N.B.; Tsvetkov, V.B.; Vanyushkina, A.A.; Varizhuk, A.M.; Rakitina, D.V.; Podgorsky, V.V.; Vishnyakov, I.E.; Kharlampieva, D.D.; Manuvera, V.A.; Lisitsyn, F.V.; Gushina, E.A.; Lazarev, V.N.; Govorun, V.M.
Interaction of Bacteroides fragilis toxin with outer membrane vesicles reveals new mechanism of its secretion and delivery
Front. Cell. Infect. Microbiol.
7
2-2
2017
Bacteroides fragilis
Jeon, J.I.; Ko, S.H.; Kim, J.M.
Intestinal epithelial cells exposed to Bacteroides fragilis enterotoxin regulates NF-kappaB activation and inflammatory responses through beta-catenin expression
Infect. Immun.
87
e00312-19
2019
Bacteroides fragilis
Choi, V.M.; Herrou, J.; Hecht, A.L.; Teoh, W.P.; Turner, J.R.; Crosson, S.; Bubeck Wardenburg, J.
Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice
Nat. Med.
22
563-567
2016
Bacteroides fragilis ATCC 43858 (A0A164V5U8)
html completed
