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Disease on EC 3.4.24.71 - endothelin-converting enzyme 1

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DISEASE
TITLE OF PUBLICATION
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Acute Coronary Syndrome
Effects of ECE-1b rs213045 and rs2038089 polymorphisms on the development of contrast-induced acute kidney injury in patients with acute coronary syndrome.
Acute Kidney Injury
Effects of ECE-1b rs213045 and rs2038089 polymorphisms on the development of contrast-induced acute kidney injury in patients with acute coronary syndrome.
Intranephron distribution and regulation of endothelin-converting enzyme-1 in cyclosporin A-induced acute renal failure in rats.
Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats.
Acute Lung Injury
Phosphoramidon, an endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.
Adenocarcinoma
Endothelin converting enzyme-1 expression in endometrial adenocarcinomas.
Modulation of human colon tumor-stromal interactions by the endothelin system.
Adenoma
Modulation of human colon tumor-stromal interactions by the endothelin system.
Adenoma, Islet Cell
Immunohistochemical localization of endothelin-converting enzyme-1 in neuroendocrine tumors and normal human tissue.
Albuminuria
Effect on blood pressure of combined inhibition of endothelin-converting enzyme and neutral endopeptidase with daglutril in patients with type 2 diabetes who have albuminuria: a randomised, crossover, double-blind, placebo-controlled trial.
Alzheimer Disease
Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme.
C-338A polymorphism of the endothelin-converting enzyme (ECE-1) gene and the susceptibility to sporadic late-onset Alzheimer's disease and coronary artery disease.
Dynamic alteration of neprilysin and endothelin-converting enzyme in age-dependent APPswe/PS1dE9 mouse model of Alzheimer's disease.
Endothelin-converting enzyme-1 activity, endothelin-1 production, and free radical-dependent vasoconstriction in Alzheimer's disease.
Endothelin-converting enzyme-1 in Alzheimer's disease and vascular dementia.
Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease.
Endothelin-converting enzyme-1 promoter polymorphisms and susceptibility to sporadic late-onset Alzheimer's disease in a Chinese population.
Major amyloid-?-degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex.
Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells.
Structural analysis of membrane-bound hECE-1 dimer using molecular modeling techniques: insights into conformational changes and A?1-42 peptide binding.
Aneurysm
Plasma endothelin and big endothelin concentrations and serum endothelin-converting enzyme activity following aneurysmal subarachnoid hemorrhage.
Arteriosclerosis
Up-regulation of endothelin-converting enzyme during the development of transplant renal arteriosclerosis in human renal allografts.
Asthma
Interleukin-1beta attenuates endothelin B receptor-mediated airway contractions in a murine in vitro model of asthma: roles of endothelin converting enzyme and mitogen-activated protein kinase pathways.
[Effect of inhaled-corticosteroids on the mRNA expressions of endothelin-1 and endothelin converting enzyme in bronchial asthma]
[Effects of butylphthalide on bronchial asthma in guinea pigs and involvement of endothelin].
[The effect of GM-CSF on endothelin-1 and endothelin converting enzyme gene expression in human airway smooth muscle cells with or without theophylline incubation]
Astrocytoma
Localization of the endothelin system in human diffuse astrocytomas.
Atherosclerosis
C-338A polymorphism of the endothelin-converting enzyme-1 gene and the susceptibility to carotid atherosclerosis.
Characterization of PgPepO, a bacterial homologue of endothelin-converting enzyme-1.
Coexpression of endothelin-converting enzyme-1 and endothelin-1 in different stages of human atherosclerosis.
Endothelin-1 and endothelin converting enzyme-1 in human atherosclerosis - novel targets for pharmacotherapy in atherosclerosis.
Endothelin-converting enzyme expression in the rat vascular injury model and human coronary atherosclerosis.
Endothelin-converting enzyme-1 increases in atherosclerotic mice: potential role of oxidized low density lipoproteins.
Enhanced endothelin-converting enzyme immunoreactivity in early atherosclerosis.
Expression and localization of human endothelin-converting enzyme-1 isoforms in symptomatic atherosclerotic disease and saphenous vein.
Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX.
Modulation of functionally active endothelin-converting enzyme by chronic neutral endopeptidase inhibition in experimental atherosclerosis.
Stimulated release of endothelin-converting enzyme is simultaneous with tissue-type plasminogen activator and decrease in coronary heart disease.
Vascular endothelial growth factor increases endothelin-converting enzyme expression in vascular endothelial cells.
Bacterial Infections
Up-regulation in endothelin-1 by Helicobacter pylori lipopolysaccharide interferes with gastric mucin synthesis via epidermal growth factor receptor transactivation.
Brain Ischemia
Prophylactic use of melatonin protects against focal cerebral ischemia in mice: role of endothelin converting enzyme-1.
Breast Neoplasms
Human breast cancer cells contain a phosphoramidon-sensitive metalloproteinase which can process exogenous big endothelin-1 to endothelin-1: a proposed mitogen for human breast fibroblasts.
On the role of endothelin-converting enzyme-1 (ECE-1) and neprilysin in human breast cancer.
Carcinogenesis
Endothelin-converting enzyme-1 in cancer aggressiveness.
The endothelin axis: a novel target for pharmacotherapy of female malignancies.
Carcinoid Tumor
Immunohistochemical localization of endothelin-converting enzyme-1 in neuroendocrine tumors and normal human tissue.
Carcinoma
ECE-1 overexpression in head and neck cancer is associated with poor tumor differentiation and patient outcome.
Endothelin converting enzyme-1 expression in endometrial adenocarcinomas.
Expression of endothelin-1 is related to poor prognosis in non-small cell lung carcinoma.
High endothelin-converting enzyme-1 expression independently predicts poor survival of patients with esophageal squamous cell carcinoma.
Modulation of human colon tumor-stromal interactions by the endothelin system.
Small interfering RNA molecules targeting endothelin-converting enzyme-1 inhibit endothelin-1 synthesis and the invasive phenotype of ovarian carcinoma cells.
[Association of CD133 and endothelin-converting enzyme expressions with prognosis of non-small cell lung carcinoma]
Carcinoma, Medullary
Immunohistochemical localization of endothelin-converting enzyme-1 in neuroendocrine tumors and normal human tissue.
Carcinoma, Non-Small-Cell Lung
Expression of endothelin-1 is related to poor prognosis in non-small cell lung carcinoma.
[Association of CD133 and endothelin-converting enzyme expressions with prognosis of non-small cell lung carcinoma]
Carcinoma, Renal Cell
Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2.
Carcinoma, Squamous Cell
ECE-1 overexpression in head and neck cancer is associated with poor tumor differentiation and patient outcome.
Endothelin system in oral squamous carcinoma cells: Specific siRNA targeting of ECE-1 blocks cell proliferation.
Cardiomyopathies
Attenuation of Doxorubicin-induced cardiomyopathy by endothelin-converting enzyme-1 ablation through prevention of mitochondrial biogenesis impairment.
Expression of endothelin-1 and endothelin-converting enzyme-1 mRNAs and proteins in failing human hearts.
Cardiovascular Diseases
Alternative pathway to endothelin-converting enzyme for the synthesis of endothelin in human blood vessels.
Cellular expression of isoforms of endothelin-converting enzyme-1 (ECE-1c, ECE-1b and ECE-1a) and endothelin-converting enzyme-2.
Clinical significance of endothelin in cardiovascular disease.
Endothelin converting-enzyme-1 mRNA expression in human cardiovascular disease.
Endothelin-converting enzyme inhibitors: their application in cardiovascular diseases.
Endothelin-converting enzyme-1 mRNA expression in human cardiovascular disease.
Endothelin: role in hypertension.
Metallopeptide-promoted inactivation of angiotensin-converting enzyme and endothelin-converting enzyme 1: toward dual-action therapeutics.
Modulation of functionally active endothelin-converting enzyme by chronic neutral endopeptidase inhibition in experimental atherosclerosis.
Physiological relevance of hydrolysis of atrial natriuretic Peptide by endothelin-converting enzyme-1.
The endothelin-converting enzyme from human umbilical vein is a membrane-bound metalloprotease similar to that from bovine aortic endothelial cells.
The role of endothelins and their receptors in heart failure.
The therapeutic potential of endothelin-1 receptor antagonists and endothelin-converting enzyme inhibitors on the cardiovascular system.
Utility of endothelin-converting enzyme inhibitors for the treatment of cardiovascular diseases.
Carotid Artery Diseases
Association of Endothelin-converting Enzyme-1b C-338A Polymorphism with Increased Risk of Ischemic Stroke in Chinese Han Population.
C-338A polymorphism of the endothelin-converting enzyme-1 gene and the susceptibility to carotid atherosclerosis.
Cerebrovascular Disorders
Therapeutic effects of endothelin receptor antagonists in stroke.
Chalazion
Endothelin-1 and endothelin-converting enzyme-1 in human granulomatous pathology of eyelid: an immunohistochemical and in situ hybridization study in chalazia.
Colitis
Effects of the endothelin-converting enzyme inhibitor SM-19712 in a mouse model of dextran sodium sulfate-induced colitis.
Colonic Neoplasms
Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability.
Colorectal Neoplasms
Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-??
Congenital Abnormalities
Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch.
Coronary Artery Disease
Alterations of endothelin-converting enzyme expression in early and advanced stages of human coronary atherosclerosis.
C-338A polymorphism of the endothelin-converting enzyme (ECE-1) gene and the susceptibility to sporadic late-onset Alzheimer's disease and coronary artery disease.
Endothelin-converting enzyme expression in the rat vascular injury model and human coronary atherosclerosis.
Endothelin-converting enzyme-1b C-338A polymorphism is associated with the increased risk of coronary artery disease in Chinese population.
Risk of coronary artery disease as influenced by variants of the human endothelin and endothelin-converting enzyme genes.
Tissue endothelin-converting enzyme activity correlates with cardiovascular risk factors in coronary artery disease.
Coronary Disease
Selective Indole-Based ECE Inhibitors: Synthesis and Pharmacological Evaluation.
Stimulated release of endothelin-converting enzyme is simultaneous with tissue-type plasminogen activator and decrease in coronary heart disease.
Crohn Disease
Enhanced expressions of endothelin-converting enzyme and endothelin receptors in human colonic tissues of Crohn's disease.
Dementia
Endothelin-converting enzymes degrade ?-synuclein and are reduced in dementia with Lewy bodies.
Transducible P11-CNTF rescues the learning and memory impairments induced by amyloid-beta peptide in mice.
Dementia, Vascular
Endothelin-converting enzyme-1 in Alzheimer's disease and vascular dementia.
Diabetes Mellitus, Type 1
Downregulation of renal endothelin-converting enzyme 2 expression in early autoimmune diabetes.
Diabetes Mellitus, Type 2
Effect on blood pressure of combined inhibition of endothelin-converting enzyme and neutral endopeptidase with daglutril in patients with type 2 diabetes who have albuminuria: a randomised, crossover, double-blind, placebo-controlled trial.
Diabetic Cardiomyopathies
A novel endothelin receptor antagonist CPU0213 improves diabetic cardiac insufficiency attributed to up-regulation of the expression of FKBP12.6, SERCA2a, and PLB in rats.
Diabetic Nephropathies
Role of protein kinase C in the expression of endothelin converting enzyme-1.
DiGeorge Syndrome
Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene.
Endometrial Neoplasms
Endothelin converting enzyme-1 expression in endometrial adenocarcinomas.
endothelin-converting enzyme 1 deficiency
Impaired ventilatory responses to hypoxia in mice deficient in endothelin-converting-enzyme-1.
Endotoxemia
Regional distribution of endothelin-1 and endothelin converting enzyme-1 in porcine endotoxemia.
Esophageal Squamous Cell Carcinoma
High endothelin-converting enzyme-1 expression independently predicts poor survival of patients with esophageal squamous cell carcinoma.
Gastritis
Omeprazole fails to suppress up-regulation of gastric mucosal endothelin-converting enzyme-1 by Helicobacter pylori lipopolysaccharide.
Up-regulation of endothelin-converting enzyme-1 in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide.
Glaucoma
An immunohistochemical study of endothelin-1 converting enzyme in the human eye.
Glioblastoma
Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.
The endothelin system in human glioblastoma.
Glioma
Expression of endothelin-converting enzyme in both neuroblastoma and glial cell lines and its localization in rat hippocampus.
Hypoxic regulation of EDN1, EDNRA, EDNRB, and ECE1 gene expressions in ERN1 knockdown U87 glioma cells.
Head and Neck Neoplasms
ECE-1 overexpression in head and neck cancer is associated with poor tumor differentiation and patient outcome.
Heart Failure
Angiotensin-converting enzyme inhibitor therapy prevents upregulation of endothelin-converting enzyme-1 in failing human myocardium.
Atrial natriuretic peptide and regulation of vascular function in hypertension and heart failure: implications for novel therapeutic strategies.
Chronic effects of an endothelin-converting enzyme inhibitor on cardiorenal and hormonal function in heart failure.
Deloading of the left ventricle by ventricular assist device normalizes increased expression of endothelin ET(A) receptors but not endothelin-converting enzyme-1 in patients with end-stage heart failure.
Early activation of cardiac and renal endothelin systems in experimental heart failure.
Effect of single doses of SLV306, an inhibitor of both neutral endopeptidase and endothelin-converting enzyme, on pulmonary pressures in congestive heart failure.
Effects of a specific endothelin-converting enzyme inhibitor on cardiac, renal, and neurohumoral functions in congestive heart failure: comparison of effects with those of endothelin A receptor antagonism.
Endothelin-1 promotes vascular structural remodeling during the progression of heart failure prevention of vascular remodeling using a specific endothelin-converting enzyme inhibitor.
Endothelin-converting enzyme inhibition in the rat model of acute heart failure: heart function and neurohormonal activation.
Endothelin-converting enzyme-1 mRNA expression in human cardiovascular disease.
Expression and activity of pulmonary endothelin converting enzyme in heart failure: relation to endothelin biosynthesis and receptor distribution.
Expression of endothelin-1, endothelin-converting enzyme, and endothelin receptors in chronic heart failure.
Increased expression of endothelin-converting enzyme-1 in failing human myocardium.
Renal endothelin-converting enzyme in rats with congestive heart failure.
Sustained improvement of cardiac function and prevention of cardiac remodeling after long-term dual ECE-NEP inhibition in rats with congestive heart failure.
Vasodilator effects of endothelin-converting enzyme inhibition and endothelin ETA receptor blockade in chronic heart failure patients treated with ACE inhibitors.
[Endothelins and chronic cardiac insufficiency]
Herpes Zoster
Cellular distribution of endothelin-converting enzyme-1 in human tissues.
Hirschsprung Disease
A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction.
Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene.
Hyperglycemia
Downregulation of renal endothelin-converting enzyme 2 expression in early autoimmune diabetes.
Effect of Anthocyanin-Rich Extract of Sour Cherry for Hyperglycemia-Induced Inflammatory Response and Impaired Endothelium-Dependent Vasodilation.
Role of protein kinase C in the expression of endothelin converting enzyme-1.
Hyperinsulinism
Hyperinsulinemia increases placenta endothelin-converting enzyme-1 expression in trophoblasts.
Hyperphosphatemia
Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin-1 production.
Hyperpigmentation
Biochemical characterization of endothelin-converting enzyme-1alpha in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis.
Hypertension
A new ATP-sensitive potassium channel opener protects the kidney from hypertensive damage in spontaneously hypertensive rats.
Angiotensin-converting enzyme as a potential target for treatment of Alzheimer's disease: inhibition or activation?
Association of genetic polymorphisms of endothelin-converting enzyme-1 gene with hypertension in a Japanese population and rare missense mutation in preproendothelin-1 in Japanese hypertensives.
Atrial natriuretic peptide and regulation of vascular function in hypertension and heart failure: implications for novel therapeutic strategies.
Chronic vasopeptidase inhibition restores endothelin-converting enzyme activity and normalizes endothelin levels in salt-induced hypertension.
Endothelin as a regulator of cardiovascular function in health and disease.
Endothelin converting enzyme-1 gene expression in the kidney of spontaneously hypertensive rats.
Endothelin-converting enzyme-1 increases in atherosclerotic mice: potential role of oxidized low density lipoproteins.
In vivo role of endothelin-converting enzyme-1 as examined by adenovirus-mediated overexpression in rats.
Mechanisms of FK 506-induced hypertension in the rat.
Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production.
Regulation of vascular contractility and blood pressure by the E2F2 transcription factor.
[Chronic theatment with an endothelin-converting enzyme inhibitor reduces the development of hypoxia-induced pulmonary hypertension in rat]
[Endothelins--physiology, pathophysiology and importance in arterial hypertension]
Hypertension, Pregnancy-Induced
[Genetic variability of endothelin-1 system in gestational hypertension and preeclampsia].
Hypertension, Pulmonary
Blockade of endothelin-converting enzyme reduces pulmonary hypertension after cardiopulmonary bypass and circulatory arrest.
Effect of small hairpin RNA targeting endothelin-converting enzyme-1 in monocrotaline-induced pulmonary hypertensive rats.
Endothelin converting enzyme inhibitor protects development of right ventricular overload and medial thickening of pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension.
Increased lung preproET-1 and decreased ETB-receptor gene expression in fetal pulmonary hypertension.
Nitric oxide and endothelin-1 in pulmonary hypertension.
Role of endothelial and smooth muscle cells in the physiopathology and treatment management of pulmonary hypertension.
The role of endothelin converting enzyme inhibition during group B streptococcus-induced pulmonary hypertension in newborn piglets.
[Chronic theatment with an endothelin-converting enzyme inhibitor reduces the development of hypoxia-induced pulmonary hypertension in rat]
Idiopathic Pulmonary Fibrosis
Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines.
Infarction, Middle Cerebral Artery
Functional neuroprotective effect of CGS 26303, a dual ECE inhibitor, on ischemic-reperfusion spinal cord injury in rats.
Neuroprotective Effect of CGS 26303, an Endothelin-converting Enzyme Inhibitor, on Transient Middle Cerebral Artery Occlusion in Rats.
Infections
Endothelin in a murine model of cerebral malaria.
Up-regulation of endothelin-converting enzyme-1 in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide.
Ischemic Stroke
Association of Endothelin-converting Enzyme-1b C-338A Polymorphism with Increased Risk of Ischemic Stroke in Chinese Han Population.
Kidney Failure, Chronic
Endothelin-converting enzyme-1 inhibition and renoprotection in end-stage renal disease.
The influence of the endothelin-converting enzyme-1 gene polymorphism on the progression of autosomal dominant polycystic kidney disease.
Lentigo
The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis.
Lewy Body Disease
Endothelin-converting enzymes degrade ?-synuclein and are reduced in dementia with Lewy bodies.
Liver Cirrhosis
Activation of the hepatic endothelin-system in rats with biliary liver fibrosis.
Increased immunoreactivities against endothelin-converting enzyme-1 and monocyte chemotactic protein-1 in hepatic stellate cells of rat fibrous liver induced by thioacetamide.
Low Tension Glaucoma
An immunohistochemical study of endothelin-1 converting enzyme in the human eye.
Lung Neoplasms
Studies on the expression of endothelin, its receptor subtypes, and converting enzymes in lung cancer and in human bronchial epithelium.
Lymphatic Metastasis
High endothelin-converting enzyme-1 expression independently predicts poor survival of patients with esophageal squamous cell carcinoma.
Melanoma
Chemokine- and cytokine-induced expression of endothelin 1 and endothelin-converting enzyme 1 in endothelial cells.
Muscle Spasticity
Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of protein kinase C constrictor pathway.
Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of Rho kinase constrictor pathway.
Myocardial Infarction
Effect of a highly selective endothelin-converting enzyme inhibitor on cardiac remodeling in rats after myocardial infarction.
Endothelin converting-enzyme-1 mRNA expression in human cardiovascular disease.
Endothelin-converting enzyme and angiotensin-converting enzyme in failing hearts of rats with myocardial infarction.
Endothelin-converting enzyme-1 mRNA expression in human cardiovascular disease.
Myocardial Ischemia
Endothelin-converting enzyme inhibition in the rat model of acute heart failure: heart function and neurohormonal activation.
[Correction of cardiac functions in rats with experimental myocardial ischemia by chronic administration of endothelin-converting enzyme inhibitor]
Neoplasm Metastasis
High endothelin-converting enzyme-1 expression independently predicts poor survival of patients with esophageal squamous cell carcinoma.
On the role of endothelin-converting enzyme-1 (ECE-1) and neprilysin in human breast cancer.
TIMAP, the versatile protein phosphatase 1 regulator in endothelial cells.
Neoplasms
CPU0213, a novel endothelin receptor antagonist, ameliorates septic renal lesion by suppressing ET system and NF-kappaB in rats.
ECE-1 overexpression in head and neck cancer is associated with poor tumor differentiation and patient outcome.
Effect of Anthocyanin-Rich Extract of Sour Cherry for Hyperglycemia-Induced Inflammatory Response and Impaired Endothelium-Dependent Vasodilation.
Endothelin-1 as a Mediator of Heme Oxygenase-1-Induced Stemness in Colorectal Cancer: Influence of p53.
Endothelin-2 synthesis is stimulated by the type-1 tumour necrosis factor receptor and cAMP: comparison with endothelin-converting enzyme-1 expression.
Endothelin-converting enzyme-1 (ECE-1) is post-transcriptionally regulated by alternative polyadenylation.
Endothelin-converting enzyme-1 in cancer aggressiveness.
Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.
Expression of endothelin-1 is related to poor prognosis in non-small cell lung carcinoma.
Herpesvirus saimiri (HVS)-based endothelin converting enzyme-1 (ECE-1) shRNA expression decreases prostate cancer cell invasion and migration.
High endothelin-converting enzyme-1 expression independently predicts poor survival of patients with esophageal squamous cell carcinoma.
Immunohistochemical localization of endothelin-converting enzyme-1 in neuroendocrine tumors and normal human tissue.
Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion.
Localization of endothelin-converting enzyme-1 in human kidney.
Localization of the endothelin system in human diffuse astrocytomas.
Nitrogen Dioxide and Ultrafine Particles Dominate the Biological Effects of Inhaled Diesel Exhaust Treated by a Catalyzed Diesel Particulate Filter.
On the role of endothelin-converting enzyme-1 (ECE-1) and neprilysin in human breast cancer.
Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells.
Selective Indole-Based ECE Inhibitors: Synthesis and Pharmacological Evaluation.
Small interfering RNA molecules targeting endothelin-converting enzyme-1 inhibit endothelin-1 synthesis and the invasive phenotype of ovarian carcinoma cells.
Stromal-epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression.
The endothelin axis: a novel target for pharmacotherapy of female malignancies.
The endothelin system in human glioblastoma.
The mechanism of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1alpha and TNF-alpha, which stimulate secretion of endothelin 1.
TIMAP, the versatile protein phosphatase 1 regulator in endothelial cells.
Nephrosis
Attenuation of puromycin aminonucleoside-induced glomerular lesions in rats by CGS 26303, a dual neutral endopeptidase/endothelin-converting enzyme inhibitor.
Nephrotic Syndrome
Regulation of endothelin-converting enzyme 1 in nephrotic syndrome in rats.
Neuroblastoma
Effects of 4-Hydroxy-Nonenal and Amyloid-beta on Expression and Activity of Endothelin Converting Enzyme and Insulin Degrading Enzyme in SH-SY5Y Cells.
Endothelin-converting enzymes degrade ?-synuclein and are reduced in dementia with Lewy bodies.
Expression of endothelin-converting enzyme in both neuroblastoma and glial cell lines and its localization in rat hippocampus.
High expression of the novel endothelin-converting enzyme genes, Nbla03145/ECEL1alpha and beta, is associated with favorable prognosis in human neuroblastomas.
Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells.
Neuroendocrine Tumors
Immunohistochemical localization of endothelin-converting enzyme-1 in neuroendocrine tumors and normal human tissue.
Neurogenic Inflammation
Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation.
Re-sensitization of neuropeptide receptors: should we stop the recycling?
Obstetric Labor, Premature
Prevention of Inflammation-Associated Preterm Birth by Knockdown of the Endothelin-1-Matrix Metalloproteinase-1 Pathway.
Paraganglioma
Immunohistochemical localization of endothelin-converting enzyme-1 in neuroendocrine tumors and normal human tissue.
Periodontal Diseases
Periodontal disease and gene-expression levels of metalloendopeptidases in human buccal mucosal epithelium.
Pheochromocytoma
Immunohistochemical localization of endothelin-converting enzyme-1 in neuroendocrine tumors and normal human tissue.
Polycystic Kidney Diseases
The influence of the endothelin-converting enzyme-1 gene polymorphism on the progression of autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
The influence of the endothelin-converting enzyme-1 gene polymorphism on the progression of autosomal dominant polycystic kidney disease.
Pre-Eclampsia
Endothelin converting enzyme (ECE) activity in normal pregnancy and preeclampsia.
Placental endothelin-converting enzyme-1 is decreased in preeclampsia.
Transfer and Vascular Effect of Endothelin Receptor Antagonists in the Human Placenta.
[Genetic variability of endothelin-1 system in gestational hypertension and preeclampsia].
Prostatic Neoplasms
Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines.
ECE-1 influences prostate cancer cell invasion via ET-1-mediated FAK phosphorylation and ET-1-independent mechanisms.
Endothelin-converting enzyme-1 (ECE-1) is post-transcriptionally regulated by alternative polyadenylation.
Expression and localization of endothelin-converting enzyme-1 in human prostate cancer.
Herpesvirus saimiri (HVS)-based endothelin converting enzyme-1 (ECE-1) shRNA expression decreases prostate cancer cell invasion and migration.
Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion.
Stromal-epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression.
Proteinuria
Inhibition of Both Neutral Endopeptidase and Endothelin-Converting Enzyme by SLV306 Reduces Proteinuria and Urinary Albumin Excretion in Diabetic Rats.
Pruritus
Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus.
Pulmonary Arterial Hypertension
[Chronic theatment with an endothelin-converting enzyme inhibitor reduces the development of hypoxia-induced pulmonary hypertension in rat]
Pulmonary Fibrosis
Endothelin-Converting Enzyme-1 Gene Ablation Attenuates Pulmonary Fibrosis via CGRP-cAMP/EPAC1 Pathway.
Renal Insufficiency
Endothelin in renal diseases and cardiovascular remodeling in renal failure.
Selective Indole-Based ECE Inhibitors: Synthesis and Pharmacological Evaluation.
Renal Insufficiency, Chronic
Therapeutic Effect of Endothelin-Converting Enzyme Inhibitor on Chronic Kidney Disease through the Inhibition of Endoplasmic Reticulum Stress and the NLRP3 Inflammasome.
Reperfusion Injury
Combination therapy of N-acetylcysteine, sodium nitroprusside and phosphoramidon attenuates ischemia-reperfusion injury in rat kidney.
Phosphoramidon, an endothelin converting enzyme inhibitor attenuates local gastric ischemia-reperfusion injury in rats.
Rhinitis
Co-expression of endothelin-1 and endothelin-converting enzyme-1 in patients with chronic rhinitis.
Scleroderma, Systemic
dsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblasts.
Serum activity of endothelin-converting enzyme correlates negatively with vital capacity in systemic sclerosis.
Sepsis
Endothelin-converting enzyme-1-mediated signaling in adult rat ventricular myocyte contractility and apoptosis during sepsis.
Squamous Cell Carcinoma of Head and Neck
ECE-1 overexpression in head and neck cancer is associated with poor tumor differentiation and patient outcome.
Stomach Neoplasms
Association of endothelin-converting enzyme-1b C-338A polymorphism with gastric cancer risk: a case-control study.
Stroke
Novel therapy approach in primary stroke prevention: simultaneous inhibition of endothelin converting enzyme and neutral endopeptidase in spontaneously hypertensive, stroke-prone rats improves survival.
Subarachnoid Hemorrhage
Attenuation of experimental subarachnoid hemorrhage-induced cerebral vasospasm by CGS 26303, an endothelin-converting enzyme inhibitor.
Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor.
CGS 26303 Upregulates mRNA Expression of Heme Oxygenase-1 in Brain Tissue of Rats Subjected to Experimental Subarachnoid Hemorrhage.
Continuous intravenous infusion of CGS 26303, an endothelin-converting enzyme inhibitor, prevents and reverses cerebral vasospasm after experimental subarachnoid hemorrhage.
Effect of endothelin-converting enzyme inhibitors on big endothelin-1 induced contraction in isolated rat basilar artery.
Plasma endothelin and big endothelin concentrations and serum endothelin-converting enzyme activity following aneurysmal subarachnoid hemorrhage.
Prevention and reversal of cerebral vasospasm by an endothelin-converting enzyme inhibitor, CGS 26303, in an experimental model of subarachnoid hemorrhage.
Soluble and Catalytically Active Endothelin Converting Enzyme-1 is Present in Cerebrospinal Fluid of Subarachnoid Hemorrhage Patients.
Systemic administration of an inhibitor of endothelin-converting enzyme for attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage.
[D-Val22]big ET-1[16-38] inhibits endothelin-converting enzyme activity: a promising concept in the prevention of cerebral vasospasm.
Tuberculosis
The endothelin system has a significant role in the pathogenesis and progression of Mycobacterium tuberculosis infection.
Ureteral Obstruction
Endothelin converting enzyme-1 (ECE-1) deletion in association with Endothelin-1 downregulation ameliorates kidney fibrosis in mice.
Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation.
Vascular Diseases
Chemokine- and cytokine-induced expression of endothelin 1 and endothelin-converting enzyme 1 in endothelial cells.
Vascular System Injuries
Endothelin inhibition delays onset of hyperglycemia and associated vascular injury in type I diabetes: evidence for endothelin release by pancreatic islet beta-cells.
Endothelin-converting enzyme expression in the rat vascular injury model and human coronary atherosclerosis.
Vasospasm, Intracranial
Attenuation of experimental subarachnoid hemorrhage-induced cerebral vasospasm by CGS 26303, an endothelin-converting enzyme inhibitor.
Attenuation of experimental subarachnoid hemorrhage-induced increases in circulating intercellular adhesion molecule-1 and cerebral vasospasm by the endothelin-converting enzyme inhibitor CGS 26303.
CGS 26303 Upregulates mRNA Expression of Heme Oxygenase-1 in Brain Tissue of Rats Subjected to Experimental Subarachnoid Hemorrhage.
Continuous intravenous infusion of CGS 26303, an endothelin-converting enzyme inhibitor, prevents and reverses cerebral vasospasm after experimental subarachnoid hemorrhage.
Endothelin and subarachnoid hemorrhage-induced cerebral vasospasm: pathogenesis and treatment.
Oral administration of an inhibitor of endothelin-converting enzyme attenuates cerebral vasospasm following experimental subarachnoid haemorrhage in rabbits.
Prevention and reversal of cerebral vasospasm by an endothelin-converting enzyme inhibitor, CGS 26303, in an experimental model of subarachnoid hemorrhage.
Prevention and reversal of vasospasm and ultrastructural changes in basilar artery by continuous infusion of CGS 35066 following subarachnoid hemorrhage.
Systemic administration of an inhibitor of endothelin-converting enzyme for attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage.
[D-Val22]big ET-1[16-38] inhibits endothelin-converting enzyme activity: a promising concept in the prevention of cerebral vasospasm.