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Disease on EC 3.4.24.7 - interstitial collagenase

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DISEASE
TITLE OF PUBLICATION
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Abruptio Placentae
Thrombin-enhanced matrix metalloproteinase-1 expression: a mechanism linking placental abruption with premature rupture of the membranes.
Acute Coronary Syndrome
Serum MMP-9 Diagnostics, Prognostics, and Activation in Acute Coronary Syndrome and Its Recurrence.
Acute Lung Injury
Matrix metalloproteinases and lung injury.
Adenocarcinoma
APE1 Upregulates MMP-14 via Redox-Sensitive ARF6-Mediated Recycling to Promote Cell Invasion of Esophageal Adenocarcinoma.
Clinical significance of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric cancer.
Clinicopathologic and prognostic significance of matrix metalloproteinases in rectal cancer.
Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (MT-MMPs) in association with MMP2 activation in injured human livers.
Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis.
Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck.
Expression and localization of membrane-type-1 matrix metalloproteinase, CD 44, and laminin-5gamma2 chain during colorectal carcinoma tumor progression.
Expression of c-ets-1, collagenase 1, and urokinase-type plasminogen activator genes in lung carcinomas.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression.
Expression of MMP-2 and MMP-9, their inhibitors, and the activator MT1-MMP in primary breast carcinomas.
Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric adenocarcinoma.
Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.
In vivo imaging of membrane type-1 matrix metalloproteinase with a novel activatable near-infrared fluorescence probe.
Induction of membrane-type matrix metalloproteinase 1 (MT1-MMP) expression in human fibroblasts by breast adenocarcinoma cells.
Interstitial collagenase gene expression in colonic neoplasia.
Localization of MT1-MMP, TIMP-1, TIMP-2, and TIMP-3 messenger RNA in normal, hyperplastic, and neoplastic endometrium. Enhanced expression by endometrial adenocarcinomas is associated with low differentiation.
Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis.
Membrane-bound MMP-14 protease-activatable adeno-associated viral vectors for gene delivery to pancreatic tumors.
MT1-MMP and MMP-7 in invasion and metastasis of human cancers.
MT1-MMP cooperates with KrasG12D to promote pancreatic fibrosis through increased TGF-{beta} signaling.
MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression.
MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway.
No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China.
p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer.
Prognostic significance of stromal metalloproteinase-2 in ovarian adenocarcinoma and its relation to carcinoma progression.
Restricted expression of membrane type 1-matrix metalloproteinase by myofibroblasts adjacent to human breast cancer cells.
The expression of MMP-14 and microRNA-410 in FFPE tissues of human endometrial adenocarcinoma.
[Changes of lymphatic vessel density in lung adenocarcinoma in situ, minimally invasive adenocarcinoma, and invasive adenocarcinoma and the regulatory factors].
Adenocarcinoma of Lung
Expression of extracellular matrix molecules in brain metastasis.
The role of matrix metalloproteinase in the intimal sarcoma-like cells derived from endarterectomized tissues from a chronic thromboembolic pulmonary hypertension patient.
[MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells].
Adenocarcinoma, Follicular
Matrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma of children and adolescents.
Adenoma
Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck.
Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis.
Expression of matrix metalloproteinases (MMP-2, MMP-9, MT1-MMP) and their inhibitors (TIMP-1, TIMP-2) in common epithelial tumors of the ovary.
Expression of matrix metalloproteinases in benign and malignant follicular thyroid lesions.
Interstitial collagenase gene expression in colonic neoplasia.
Matrix metalloproteases expression in different histological types of colorectal polyps.
Metalloproteinases ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas.
Adenomatous Polyposis Coli
Expression and localization of membrane-type-1 matrix metalloproteinase, CD 44, and laminin-5gamma2 chain during colorectal carcinoma tumor progression.
RHBDF1 regulates APC-mediated stimulation of the epithelial-to-mesenchymal transition and proliferation of colorectal cancer cells in part via the Wnt/?-catenin signalling pathway.
Adenomatous Polyps
Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?
Agenesis of Corpus Callosum
MT1-MMP deficiency leads to defective ependymal cell maturation, impaired ciliogenesis, and hydrocephalus.
Aggressive Periodontitis
Collagenase activity in gingival crevicular fluid of patients with juvenile periodontitis.
Tetracycline inhibition identifies the cellular origin of interstitial collagenases in human periodontal diseases in vivo.
Tetracycline inhibition identifies the cellular sources of collagenase in gingival crevicular fluid in different forms of periodontal diseases.
Alveolar Bone Loss
Matrix Metalloproteinases, Tissue Inhibitor of Matrix Metalloproteinase-1, and Laminin-5 ?2 Chain Immunolocalization in Gingival Tissue of Endotoxin-Induced Periodontitis in Rats: Effects of Low-Dose Doxycycline and Alendronate.
Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate.
Alzheimer Disease
Abnormal Expression and Distribution of MMP2 at Initial Stages of Alzheimer's Disease-Related Pathology.
Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease.
Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP.
Emerging Alternative Proteinases in APP Metabolism and Alzheimer's Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP.
Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Ameloblastoma
Expression and role of metalloproteinase-2 and endogenous tissue regulator in ameloblastoma.
Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors.
Amyloidosis
Chaperone Nanobodies Protect Gelsolin Against MT1-MMP Degradation and Alleviate Amyloid Burden in the Gelsolin Amyloidosis Mouse Model.
Overexpression of serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21WAF-1/Cip-1/Sdi-1 expression.
Amyotrophic Lateral Sclerosis
Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Aneurysm
A potential key mechanism in ascending aortic aneurysm development: Detection of a linear relationship between MMP-14/TIMP-2 ratio and active MMP-2.
Adverse drug reaction prediction using scores produced by large-scale drug-protein target docking on high-performance computing machines.
Early Increased MT1-MMP Expression and Late MMP-2 and MMP-9 Activity during Angiotensin II Induced Aneurysm Formation.
Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta.
Ubiquitous elevation of matrix metalloproteinase-2 expression in the vasculature of patients with abdominal aneurysms.
Vascular extracellular matrix remodeling in cerebral aneurysms.
Angiofibroma
Metalloproteinases in juvenile angiofibroma--a collagen rich tumor.
Aortic Aneurysm
Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions.
Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms.
Localization of matrix metalloproteinase 2 within the aneurysmal and normal aortic wall.
Aortic Aneurysm, Abdominal
Cellular localization of matrix metalloproteinases in the abdominal aortic aneurysm wall.
Demonstration of interstitial collagenase in abdominal aortic aneurysm disease.
Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo.
Aortic Valve Stenosis
A Possible Early Biomarker for Bicuspid Aortopathy: Circulating Transforming Growth Factor ?-1 to Soluble Endoglin Ratio.
Arthritis
Assignments, secondary structure and dynamics of the inhibitor-free catalytic fragment of human fibroblast collagenase.
Design and synthesis of sulfur based inhibitors of matrix metalloproteinase-1.
Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis.
Influence of Matrix metalloproteinase 1 and 3 genetic variations on susceptibility and severity of juvenile idiopathic arthritis.
Isolation and characterization of human monoclonal antibodies specific to MMP-1A, MMP-2 and MMP-3.
Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism.
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover.
Mutation of Membrane Type-1 Metalloproteinase, MT1-MMP, Causes the Multicentric Osteolysis and Arthritis Disease Winchester Syndrome.
New biochemical insight of conserved water molecules at catalytic and structural Zn(2+) ions in human matrix metalloproteinase-I: a study by MD-simulation.
Overexpression of serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21WAF-1/Cip-1/Sdi-1 expression.
Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade.
The road forward: The scientific basis for tetracycline treatment of arthritic disorders.
Arthritis, Experimental
Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.
Prevention of progressive joint destruction in collagen-induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR255031.
Arthritis, Juvenile
Influence of Matrix metalloproteinase 1 and 3 genetic variations on susceptibility and severity of juvenile idiopathic arthritis.
Arthritis, Reactive
Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis.
Arthritis, Rheumatoid
A high throughput fluorogenic substrate for interstitial collagenase (MMP-1) and gelatinase (MMP-9).
Analysis for the major contributor of collagenase to the primary cleavage of type II collagens in cartilage degradation.
Collagenase (MMP-1) and TIMP-1 in destructive corneal disease associated with rheumatoid arthritis.
Collagenase-1 (MMP-1) and HLA-DRB1 gene polymorphisms in rheumatoid arthritis: a prospective longitudinal study.
Determination of interstitial collagenase (MMP-1) in patients with rheumatoid arthritis.
Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis.
Examination of recombinant truncated mature human fibroblast collagenase by mass spectrometry: identification of differences with the published sequence and determination of stable isotope incorporation.
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in rheumatoid synovium.
Expression of membrane-type 1 matrix metalloproteinase in rheumatoid synovial cells.
Expression of metalloproteinases and metalloproteinase inhibitor in human arthritic synovium.
Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts.
Follistatin-like protein 1 induction of matrix metalloproteinase 1, 3 and 13 gene expression in rheumatoid arthritis synoviocytes requires MAPK, JAK/STAT3 and NF-?B pathways.
From supernatants to cytokines: a personal view on the early history of IL-1, IL-1Ra, TNF and its inhibitor in rheumatology.
Immobilized anti-CD3 antibody activates T cell clones to induce the production of interstitial collagenase, but not tissue inhibitor of metalloproteinases, in monocytic THP-1 cells and dermal fibroblasts.
Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase.
Membrane-type I matrix metalloproteinase-dependent regulation of rheumatoid arthritis synoviocyte function.
MT1-MMP: a potent modifier of pericellular microenvironment.
Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts.
p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression.
Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy.
Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis.
Regulation of human synovial fibroblast collagenase messenger RNA by interleukin-1.
Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblasts.
Retroviral gene transfer of an antisense construct against membrane type 1 matrix metalloproteinase reduces the invasiveness of rheumatoid arthritis synovial fibroblasts.
Ribozymes that inhibit the production of matrix metalloproteinase 1 reduce the invasiveness of rheumatoid arthritis synovial fibroblasts.
Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts.
Stimulation of collagenase 3 expression in synovial fibroblasts of patients with rheumatoid arthritis by contact with a three-dimensional collagen matrix or with normal cartilage when coimplanted in NOD/SCID mice.
The involvement of matrix metalloproteinases and inflammation in lumbar disc herniation.
The nuclear receptor corepressor SMRT inhibits interstitial collagenase (MMP-1) transcription through an HRE-independent mechanism.
Variation of Matrix Metalloproteinase 1 and 3 Haplotypes and Their Serum Levels in Patients with Rheumatoid Arthritis and Osteoarthritis.
Asthma
Broncho-alveolar macrophages express chemokines associated with leukocyte migration in a mouse model of asthma.
Long-term pathologic consequences of acute irritant-induced asthma.
[The analysis of amount of matrix metalloproteinase 1 precursor, metalloproteinase 1 tissue inhibitor and cystatin C in the bronchoalveolar secretion of patients with nonspecific lung diseases].
Astrocytoma
Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors.
Matrix metalloproteinase-9 interplays with the IGFBP2-IGFII complex to promote cell growth and motility in astrocytomas.
Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression.
Atherosclerosis
Acceleration of matrix metalloproteinase-1 production and activation of platelet-derived growth factor receptor beta in human coronary smooth muscle cells by oxidized LDL and 4-hydroxynonenal.
Basic FGF regulates interstitial collagenase gene expression in human smooth muscle cells.
Cleavage and functional loss of human apolipoprotein E by digestion of matrix metalloproteinase-14.
Fluvastatin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells.
Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.
Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques.
Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process.
MD-2 is involved in the stimulation of matrix metalloproteinase-1 expression by interferon-? and high glucose in mononuclear cells - a potential role of MD-2 in Toll-like receptor 4-independent signalling.
Membrane type 1 matrix metalloproteinase expression in human atherosclerotic plaques: evidence for activation by proinflammatory mediators.
Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis.
Membrane-Tethered Metalloproteinase Expressed by Vascular Smooth Muscle Cells Limits the Progression of Proliferative Atherosclerotic Lesions.
Membrane-type I matrix metalloproteinase (MT1-MMP), lipid metabolism and therapeutic implications.
Overexpression of serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21WAF-1/Cip-1/Sdi-1 expression.
Specific matrix metalloproteinases play different roles in intraplaque angiogenesis and plaque instability in rabbits.
Atrioventricular Block
Matrix metalloproteinase 1 1?G/2?G gene polymorphism is associated with acquired atrioventricular block via linking a higher serum protein level.
Bacterial Infections
Ras-oncogenic Drosophila hindgut but not midgut cells use an inflammation-like program to disseminate to distant sites.
Bicuspid Aortic Valve Disease
Low transcriptional activity haplotype of matrix metalloproteinase 1 is less frequent in bicuspid aortic valve patients.
Blister
Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis.
Urokinase plasminogen activator is expressed by basal keratinocytes before interstitial collagenase, stromelysin-1, and laminin-5 in experimentally induced dermatitis herpetiformis lesions.
Bone Diseases, Metabolic
Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice.
Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism.
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover.
Bone Resorption
1alpha,25-dihydroxyvitamin D3 regulates the expression of membrane-type matrix metalloproteinase-1 in normal human osteoblast-like cells.
Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis.
Effects of 17beta-estradiol on the expression of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-2 in human osteoblastic MG-63 cell cultures.
Immunohistochemical localization of membrane type 1-matrix metalloproteinase (MT1-MMP) in osteoclasts in vivo.
Initiation of osteoclast bone resorption by interstitial collagenase.
Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts.
Localisation of mRNA for collagenase in osteocytic, bone surface and chondrocytic cells but not osteoclasts.
Membrane Localization of Membrane Type 1 Matrix Metalloproteinase by CD44 Regulates the Activation of Pro-Matrix Metalloproteinase 9 in Osteoclasts.
Membrane-type-1 matrix metalloproteinase is abundantly expressed in fibroblasts and osteoclasts at the bone-implant interface of aseptically loosened joint arthroplasties in situ.
Minocycline impairment of both osteoid tissue removal and osteoclastic resorption in a synchronized model of remodeling in the rat.
Nitric oxide promotes infectious bone resorption by enhancing cytokine-stimulated interstitial collagenase synthesis in osteoblasts.
Parathyroid hormone inhibits the expression of membrane-type matrix metalloproteinase-1 (MT1-MMP) in osteoblast-like MG-63 cells.
The role of collagenase in bone resorption. An overview.
Transcriptional regulation of the collagenase gene by basic fibroblast growth factor in osteoblastic MC3T3-E1 cells.
[The effects of 1alpha,25-dihydroxyvitamin D3 in regulation matrix metalloproteinase and tissue metalloproteinase inhibitors in human osteoblasts.]
Bowen's Disease
Immunohistochemical demonstration of EphA2 processing by MT1-MMP in invasive cutaneous squamous cell carcinoma.
Brain Injuries, Traumatic
Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Brain Ischemia
Effects of treadmill exercise on cerebral angiogenesis and MT1-MMP expression after cerebral ischemia in rats.
Brain Neoplasms
Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation.
Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells.
Evidence of MTCBP-1 interaction with the cytoplasmic domain of MT1-MMP: Implications in the autophagy cell index of high-grade glioblastoma.
Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas.
Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells.
Modulation of invasive properties of CD133(+) glioblastoma stem cells: A role for MT1-MMP in bioactive lysophospholipid signaling.
Silencing of the MT1-MMP/ G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cells.
Tumor environment dictates medulloblastoma cancer stem cell expression and invasive phenotype.
Breast Neoplasms
A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models.
Aberrant, persistent inclusion into lipid rafts limits the tumorigenic function of membrane type-1 matrix metalloproteinase in malignant cells.
ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis, and increased tumor growth.
Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells.
An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase.
An association between the matrix metalloproteinase 1 promoter gene polymorphism and lymphnode metastasis in breast cancer.
Antitumor activity of a membrane lytic peptide cyclized with a linker sensitive to membrane type 1-matrix metalloproteinase.
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.
Assessment of the MT1-MMP expression level of different cell lines by the naked eye.
Association of BCSC-1 and MMP-14 with human breast cancer.
ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion.
Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells.
Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Cdc42-interacting protein 4 is a Src substrate that regulates invadopodia and invasiveness of breast tumors by promoting MT1-MMP endocytosis.
Cell-type specific regulation of human interstitial collagenase-1 gene expression by interleukin-1 beta (IL-1 beta) in human fibroblasts and BC-8701 breast cancer cells.
Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system.
Chemical Tools for Selective Activity Profiling of Endogenously Expressed MMP-14 in Multicellular Models.
Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase.
CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer.
Clinical relevance of cyclooxygenase-2 and matrix metalloproteinases (MMP-2 and MT1-MMP) in human breast cancer tissue.
Clinical significance of MT1-MMP mRNA expression in breast cancer.
Coagulation factor VIIa-mediated protease-activated receptor 2 activation leads to ?-catenin accumulation via the AKT/GSK3? pathway and contributes to breast cancer progression.
Control of MT1-MMP transport by atypical PKC during breast-cancer progression.
Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function.
Correlation between MMPs and their inhibitors in breast cancer tumor tissue specimens and in cell lines with different metastatic potential.
DDR1 and MT1-MMP Expression Levels Are Determinant for Triggering BIK-Mediated Apoptosis by 3D Type I Collagen Matrix in Invasive Basal-Like Breast Carcinoma Cells.
Development of a Radiolabeled Peptide-Based Probe Targeting MT1-MMP for Breast Cancer Detection.
Development of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase on malignant tumors.
Development of an optimized activatable MMP-14 targeted SPECT imaging probe.
Development of Novel Tumor-Targeted Theranostic Nanoparticles Activated by Membrane-Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy.
Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts.
DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes.
Effect of the different phosphorylated Smad2 protein localizations on the invasive breast carcinoma phenotype.
Elevated cyclic AMP suppresses ConA-induced MT1-MMP expression in MDA-MB-231 human breast cancer cells.
Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration.
EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.
Epigenetic Control of the Invasion-promoting MT1-MMP/MMP-2/TIMP-2 Axis in Cancer Cells.
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas.
Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cells.
Expression of extracellular matrix molecules in brain metastasis.
Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells.
Expression of MMP-2 and MMP-9, their inhibitors, and the activator MT1-MMP in primary breast carcinomas.
Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in ductal carcinoma in situ and invasive ductal carcinoma of the breast.
Expression of the epidermal growth factor receptor (EGFR) and the phosphorylated EGFR in invasive breast carcinomas.
Expression of tissue levels of matrix metalloproteinases and their inhibitors in breast cancer.
Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase.
Gelatin zymography and substrate cleavage assays of matrix metalloproteinase-2 in breast carcinoma cells overexpressing membrane type-1 matrix metalloproteinase.
Gelatinase A, membrane type 1 matrix metalloproteinase, and extracellular matrix metalloproteinase inducer mRNA expression: correlation with invasive growth of breast cancer.
Human breast cancer cells activate procollagenase-1 and invade type I collagen: invasion is inhibited by all-trans retinoic acid.
Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation.
Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis.
Immunolocalization of matrix metalloproteinases and their inhibitors in clinical specimens of bone metastasis from breast carcinoma.
Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts.
Implication of collagen type I-induced membrane-type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in the metastatic progression of breast carcinoma.
In vitro and in vivo MMP gene expression localisation by In Situ-RT-PCR in cell culture and paraffin embedded human breast cancer cell line xenografts.
Induction of membrane-type matrix metalloproteinase 1 (MT1-MMP) expression in human fibroblasts by breast adenocarcinoma cells.
Inhibition of MT1-MMP proteolytic function and ERK1/2 signalling influences cell migration and invasion through changes in MMP-2 and MMP-9 levels.
Integrin fibronectin receptors in matrix metalloproteinase-1-dependent invasion by breast cancer and mammary epithelial cells.
Interleukin-1 beta induces interstitial collagenase gene expression and protein secretion in renal mesangial cells.
Intradomain cleavage of the inhibitory prodomain is essential to the pro-tumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP) in vivo.
Less is more: low expression of MT1-MMP is optimal to promote migration and tumourigenesis of breast cancer cells.
LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP.
Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells.
Mapping proteolytic cancer cell-extracellular matrix interfaces.
Matrix metalloproteinase 1 and circulating tumor cells in early breast cancer.
Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material.
mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization.
Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules.
Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation.
Membrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: Observations from clinical and in vitro analyses.
Membrane type-1 matrix metalloproteinase (MT1-MMP) processing of pro-alphav integrin regulates cross-talk between alphavbeta3 and alpha2beta1 integrins in breast carcinoma cells.
Membrane type-1 matrix metalloproteinase stimulates tumour cell-induced platelet aggregation: role of receptor glycoproteins.
Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells.
Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly to promote cell motility.
Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance.
Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin ?5?1 and tumour growth.
MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases.
MMP-14 Triggered Fluorescence Contrast Agent.
MMP1 expression is activated by Slug and enhances multi-drug resistance (MDR) in breast cancer.
MT1-MMP and MMP-7 in invasion and metastasis of human cancers.
MT1-MMP correlates with MMP-2 activation potential seen after epithelial to mesenchymal transition in human breast carcinoma cells.
MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis.
MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells.
MT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis.
MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src.
MT1-MMP-dependent ECM processing regulates laminB1 stability and mediates replication fork restart.
MT1-MMP: Endosomal delivery drives breast cancer metastasis.
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion.
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells.
Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP.
Neurokinin-1 receptor mediated breast cancer cell migration by increased expression of MMP-2 and MMP-14.
New pathway links from cancer-progression determinants to gene expression of matrix metalloproteinases in breast cancer cells.
Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells.
p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer.
Phagocytosis of collagen by fibroblasts and invasive cancer cells is mediated by MT1-MMP.
Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding.
Plasma matrix metalloproteinase 1, 3, and 7 levels and breast cancer risk in the Nurses' Health study.
PLD and PA Take MT1-MMP for a Metastatic Ride.
Prinomastat, a hydroxamate inhibitor of matrix metalloproteinases, has a complex effect on migration of breast carcinoma cells.
Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase.
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion.
Quantitative FRET Imaging to Visualize the Invasiveness of Live Breast Cancer Cells.
RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.
Radiation-enhancement of MDA-MB-231 breast cancer cell invasion prevented by a cyclooxygenase-2 inhibitor.
Regulation of invadopodia formation and activity by CD147.
Regulation of MT1-MMP Activity through Its Association with ERMs.
Restricted expression of membrane type 1-matrix metalloproteinase by myofibroblasts adjacent to human breast cancer cells.
Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5.
Shedding of discoidin domain receptor (DDR) 1 by membrane type (MT)-matrix metalloproteinases (MMPs).
Shedding of membrane type 1 matrix metalloproteinase in a human breast carcinoma cell line.
Significance of membrane type 1 matrix metalloproteinase expression in breast cancer.
SNX27-retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis.
Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells.
SPARC/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines.
Stimulation of MMP-11 (stromelysin-3) expression in mouse fibroblasts by cytokines, collagen and co-culture with human breast cancer cell lines.
Studies on Multifunctional Effect of All-Trans Retinoic Acid (ATRA) on Matrix Metalloproteinase-2 (MMP-2) and Its Regulatory Molecules in Human Breast Cancer Cells (MCF-7).
Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer.
Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas.
The cytoplasmic domain of MT1-MMP is dispensable for migration augmentation but necessary to mediate viability of MCF-7 breast cancer cells.
The influence of MMP-14, TIMP-2 and MMP-2 expression on breast cancer prognosis.
The membrane tethered matrix metalloproteinase MT1-MMP triggers an outside-in DNA damage response that impacts chemo- and radiotherapy responses of breast cancer.
The multiple roles of Id-1 in cancer progression.
The overexpression membrane type 1 matrix metalloproteinase is associated with the progression and prognosis in breast cancer.
The type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells.
Tissue inhibitor of metalloproteinase-2 regulates matrix metalloproteinase-2-mediated endothelial barrier dysfunction and breast cancer cell transmigration through lung microvascular endothelial cells.
TNF-? promotes breast cancer cell migration and enhances the concentration of membrane-associated proteases in lipid rafts.
TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion.
Transcriptional repression of the human collagenase-1 (MMP-1) gene in MDA231 breast cancer cells by all-trans-retinoic acid requires distal regions of the promoter.
Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases.
Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: a major induction of stromal MMP-13.
Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas.
YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis.
[Effects of MT1-MMP on the in vitro invasiveness of breast cancer cells]
[Expression pattern of membrane type-1 matrix metalloproteinase in primary breast carcinomas].
[MT1-MMP up-regulates VEGF expression in human breast carcinoma MCF-7 cells and induces tumor angiogenesis]
[Significance of membrane type-1 matrix metalloproteinase expression in breast cancer]
Bronchiectasis
[Complex search for antiprotease-protease enzyme gene polymorphisms in patients with chronic obstructive pulmonary diseases]
Bronchitis
[Complex search for antiprotease-protease enzyme gene polymorphisms in patients with chronic obstructive pulmonary diseases]
Carcinogenesis
A study on angiogenesis-related matrix metalloproteinase networks in primary hepatocellular carcinoma.
Collagenase induction promotes mouse tumorigenesis by two independent pathways.
Contribution of matrix metalloproteinases-1 genotypes to gastric cancer susceptibility in Taiwan.
Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo.
Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival.
Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine.
Expression of matrix metalloproteinases in gallbladder carcinoma and their significance in carcinogenesis.
Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2.
Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers.
Impaired tyrosine phosphorylation of membrane type 1-matrix metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates tumor growth in mice.
Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors.
Less is more: low expression of MT1-MMP is optimal to promote migration and tumourigenesis of breast cancer cells.
Lumican, pro-tumorigenic or anti-tumorigenic: A conundrum.
Matrix metalloproteinase 1 gene polymorphism as a prognostic predictor of invasive cervical cancer.
Matrix metalloproteinase 1 promotes tumorigenesis and inhibits the sensitivity to 5-fluorouracil of nasopharyngeal carcinoma.
Matrix metalloproteinase 2 promotes cell growth and invasion in colorectal cancer.
miRNA-584-3p inhibits gastric cancer progression by repressing Yin Yang 1- facilitated MMP-14 expression.
Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer.
Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma.
Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice.
The cytoplasmic domain of MT1-MMP is dispensable for migration augmentation but necessary to mediate viability of MCF-7 breast cancer cells.
The polymorphism MMP1 -1607 (1G>2G) is associated with a significantly increased risk of cancers from a meta-analysis.
The role of matrix metalloproteinase in the intimal sarcoma-like cells derived from endarterectomized tissues from a chronic thromboembolic pulmonary hypertension patient.
TIMP-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells.
TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway.
[The role of matrix metalloproteinases and their tissue inhibitors in oral lichen planus]
[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].
Carcinoma
Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2.
Activation of pro-MMP-2 mediated by MT1-MMP in human salivary gland carcinomas: possible regulation of pro-MMP-2 activation by TIMP-2.
AG-9, an Elastin-Derived Peptide, Increases In Vitro Oral Tongue Carcinoma Cell Invasion, through an Increase in MMP-2 Secretion and MT1-MMP Expression, in a RPSA-Dependent Manner.
An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy.
Analysis of MT1-MMP and MMP2 expression in human gastric cancers.
Anti-invasive effect of MMI-166, a new selective matrix metalloproteinase inhibitor, in cervical carcinoma cell lines.
Augmented membrane type 1 matrix metalloproteinase (MT1-MMP):MMP-2 messenger RNA ratio in gastric carcinomas with poor prognosis.
Basic fibroblast growth factor: a missing link between collagen VII, increased collagenase, and squamous cell carcinoma in recessive dystrophic epidermolysis bullosa.
Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion.
Changes in the expression of matrix proteases and of the transcription factor c-Ets-1 during progression of precancerous bronchial lesions.
Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma.
Clinicopathologic and prognostic significance of matrix metalloproteinases in rectal cancer.
Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx.
Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo.
Construction of antisense MT1-MMP vector and its inhibitory effects on invasion of human ovarian cancer cells.
Contribution of the PI3K/MMPs/Ln-5?2 and EphA2/FAK/Paxillin signaling pathways to tumor growth and vasculogenic mimicry of gallbladder carcinomas.
Coordinated expression of integrin subunits, matrix metalloproteinases (MMP), angiogenic genes and Ets transcription factors in advanced-stage ovarian carcinoma: a possible activation pathway?
Design and characterization of a metalloproteinase inhibitor-tethered resin for the detection of active MMPs in biological samples.
Desmoplastic response in scirrhous gastric carcinoma: imbalance between collagen synthesis and degradation.
Differential expression of MMP and uPA systems and prognostic relevance of their expression in esophageal squamous cell carcinoma.
Differential localization of MT1-MMP in human prostate cancer tissue: Role of IGF-1R in MT1-MMP expression.
Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysis.
Differential stromal regulation of MMP-1 expression in benign and malignant keratinocytes.
Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck.
Dominative role of MMP-14 over MMP-15 in human urinary bladder carcinoma on the basis of its enhanced specific activity.
Down-regulation of MT1-MMP expression suppresses tumor cell invasion in metastatic human SW626 ovarian cancer cells.
E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters.
EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma.
Enhanced cell surface expression of matrix metalloproteinases and their inhibitors, and tumor-induced host response in progression of human gastric carcinoma.
Enhanced collagenase production by fibroblasts derived from human basal cell carcinomas.
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis.
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas.
Enhancement of membrane-type 1-matrix metalloproteinase (MT1-MMP) production and sequential activation of progelatinase A on human squamous carcinoma cells co-cultured with human dermal fibroblasts.
Epidermal growth factor receptor-mediated membrane type 1 matrix metalloproteinase endocytosis regulates the transition between invasive versus expansive growth of ovarian carcinoma cells in three-dimensional collagen.
Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis.
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas.
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human urothelial carcinomas.
Expression levels of vascular endothelial growth factor, matrix metalloproteinases 2 and 9 and tissue inhibitor of metalloproteinases 1 and 2 in the plasma of patients with ovarian carcinoma.
Expression of c-ets-1, collagenase 1, and urokinase-type plasminogen activator genes in lung carcinomas.
Expression of collagenase-1 (MMP-1), collagenase-3 (MMP-13) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in laryngeal squamous cell carcinomas.
Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer.
Expression of matrix metalloprotease-2 (MMP-2) and the activator membrane type 1 (MT1-MMP) in canine mammary carcinomas.
Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck.
Expression of matrix metalloproteinase-2 (MMP-2) and of membrane-type-1-matrix metalloproteinase (MT1-MMP) in transitional cell carcinoma of the upper urinary tract.
Expression of matrix metalloproteinases (MMP-2, MMP-9, MT1-MMP) and their inhibitors (TIMP-1, TIMP-2) in common epithelial tumors of the ovary.
Expression of matrix metalloproteinases in benign and malignant follicular thyroid lesions.
Expression of matrix metalloproteinases in gallbladder carcinoma and their significance in carcinogenesis.
Expression of membrane type 1 matrix metalloproteinase (MMP-14) in epithelial ovarian cancer: high level expression in clear cell carcinoma.
Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion.
Expression of membrane type 1-matrix metalloproteinase in laryngeal carcinoma.
Expression of membrane-type matrix metalloproteinase 1 (MT1-MMP) in tumor cells enhances pulmonary metastasis in an experimental metastasis assay.
Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas.
Expression of messenger RNAs for membrane-type 1, 2, and 3 matrix metalloproteinases in human renal cell carcinomas.
Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas.
Expression of metastasis-associated mts1 gene is co-induced with membrane type-1 matrix metalloproteinase (MT1-MMP) during oncogenic transformation and tubular formation of Madin Darby canine kidney (MDCK) epithelial cells.
Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation.
Expression of MMP-2 and MMP-9, their inhibitors, and the activator MT1-MMP in primary breast carcinomas.
Expression of MMP-7 and MT1-MMP in oral squamous cell carcinoma as predictive indicator for tumor invasion and prognosis.
Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.
Fibroblast growth factor-1 transcriptionally induces membrane type-1 matrix metalloproteinase expression in prostate carcinoma cell line.
Gelatinase A, membrane type 1 matrix metalloproteinase, and extracellular matrix metalloproteinase inducer mRNA expression: correlation with invasive growth of breast cancer.
Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype.
High levels of MMP-2, MMP-9, MT1-MMP and TIMP-2 mRNA correlate with poor survival in ovarian carcinoma.
Higher expression and activity of metalloproteinases in human cervical carcinoma cell lines is associated with HPV presence.
HPV16 oncoproteins induce MMPs/RECK-TIMP-2 imbalance in primary keratinocytes: possible implications in cervical carcinogenesis.
Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer.
Identification of a metalloproteinase co-purifying with rat tumour collagenase and the characteristics of fragments of both enzymes.
Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers.
Identification of novel target proteins in sebaceous gland carcinoma.
Imatinib-associated matrix metalloproteinase suppression in p16-positive squamous cell carcinoma compared to HPV-negative HNSCC cells in vitro.
Immunohistochemical demonstration of EphA2 processing by MT1-MMP in invasive cutaneous squamous cell carcinoma.
Immunohistochemical detection of membrane-type-1-matrix metalloproteinase in colorectal carcinoma.
Immunolocalization of collagenase in neoplastic epithelial cells.
Implication of collagen type I-induced membrane-type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in the metastatic progression of breast carcinoma.
Increased expression of collagenase-3 (MMP-13) and MT1-MMP in oesophageal cancer is related to cancer aggressiveness.
Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas.
Increased expression of membrane type 1-matrix metalloproteinase in head and neck carcinoma.
Increased immunoreactivity of MT1-MMP and beta-catenin in high risk basal cell carcinoma.
Interaction of MT1-MMP and laminin-5gamma2 chain correlates with metastasis and invasiveness in human esophageal squamous cell carcinoma.
Interstitial collagenase (matrix metalloproteinase 1) associated with the plasma membrane of both neoplastic and nonneoplastic cells.
Interstitial collagenase from rat mammary carcinoma cells: interaction with substrates and inhibitors.
Interstitial collagenase gene expression in oral squamous cell carcinoma.
Interstitial collagenase MMP-1 and EMMPRIN in cell lines and in clinical specimens of cervical squamous cell carcinoma.
Intratumoral concentrations of tissue inhibitor of matrix metalloproteinase 1 in patients with gastric carcinoma a new biomartker for invasion and its impact on survival.
Invasion of connective tissue by human carcinoma cell lines: requirement for urokinase, urokinase receptor, and interstitial collagenase.
Key proteins of invadopodia are overexpressed in oral squamous cell carcinoma suggesting an important role of MT1-MMP in the tumoral progression.
Mammary carcinoma with osteoclast-like giant cells: a case report.
Matrix metalloproteinase 1, 3, and 9 polymorphisms and esophageal squamous cell carcinoma risk.
Matrix metalloproteinase 1: a better biomarker for squamous cell carcinoma by multiple microarray analyses.
Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation.
Matrix metalloproteinase-14 expression and its prognostic value in cervical carcinoma.
Matrix metalloproteinase-2 and -14 in p16-positive and -negative HNSCC after exposure To 5-FU and docetaxel In Vitro.
Matrix-metalloproteinases in bronchopulmonary carcinomas.
Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation.
Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor.
Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells.
Membrane type-1 matrix metalloproteinase (MT1-MMP) correlates with the expression and activation of matrix metalloproteinase-2 (MMP-2) in inflammatory breast cancer.
Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 beta3 chain and induces cell migration.
Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.
Membrane-type matrix metalloproteinases (MT-MMPs) in cell invasion.
MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines.
MMP-14 can serve as a prognostic marker in patients with supraglottic cancer.
MMP-2 and TIMP-2 expression correlates with poor prognosis in cervical carcinoma--a clinicopathologic study using immunohistochemistry and mRNA in situ hybridization.
mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas.
MT1-MMP Activation of TGF-? Signaling Enables Intercellular Activation of an Epithelial-mesenchymal Transition Program in Cancer.
MT1-MMP and MMP-2 mRNA expression in human ovarian tumors: possible implications for the role of desmoplastic fibroblasts.
MT1-MMP and MMP-7 in invasion and metastasis of human cancers.
MT1-MMP correlates with MMP-2 activation potential seen after epithelial to mesenchymal transition in human breast carcinoma cells.
MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3.
MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins.
MT3-MMP down-regulation promotes tumorigenesis and correlates to poor prognosis in esophageal squamous cell carcinoma.
Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts.
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells.
No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China.
Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination.
Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma.
Podoplanin promotes the invasion of oral squamous cell carcinoma in coordination with MT1-MMP and Rho GTPases.
Polarized MT1-MMP-CD44 interaction and CD44 cleavage during cell retraction reveal an essential role for MT1-MMP in CD44-mediated invasion.
Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth.
Presence of high levels of MT1-MMP protein in fibroblastic cells of human invasive carcinomas.
Prognostic significance of matrix metalloproteinases type I expression and tumor front parameters in the presence of lymph node micrometastases in carcinoma of the larynx.
Prognostic significance of stromal metalloproteinase-2 in ovarian adenocarcinoma and its relation to carcinoma progression.
Prognostic values of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression in bladder cancer.
Prointegrin maturation follows rapid trafficking and processing of MT1-MMP in Furin-Negative Colon Carcinoma LoVo Cells.
Protein Expression of MMP-2 and MT1-MMP in Actinic Keratosis, Squamous Cell Carcinoma of the Skin, and Basal Cell Carcinoma.
Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells.
RABGTPases in MT1-MMP trafficking and cell invasion: Physiology versus pathology.
Relation between laminin-5 gamma 2 chain and cell surface metalloproteinase MT1-MMP in clear cell carcinoma of the ovary.
SCCRO (DCUN1D1) induces extracellular matrix invasion by activating matrix metalloproteinase 2.
Sequence-specific silencing of MT1-MMP expression suppresses tumor cell migration and invasion: importance of MT1-MMP as a therapeutic target for invasive tumors.
Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder.
Single Nucleotide Polymorphisms and Haplotypes of MMP-14 are Associated with the Risk and Pathological Development of Oral Cancer.
Stimulation of skin fibroblast collagenase production by a cytokine derived from basal cell carcinomas.
Stromelysin-3 induction and interstitial collagenase repression by retinoic acid. Therapeutical implication of receptor-selective retinoids dissociating transactivation and AP-1-mediated transrepression.
The differential regulation of human telomerase reverse transcriptase and vascular endothelial growth factor may contribute to the clinically more aggressive behavior of p63-positive breast carcinomas.
The identification, purification and characterisation of an inhibitor of collagenase (20K) produced by neoplastic epithelial cells.
The Precise Diagnosis of Cancer Invasion/Metastasis via 2D Laser Ablation Mass Mapping of Metalloproteinase in Primary Cancer Tissue.
The prognostic value of metalloproteinases and angiogenic factors in ovarian carcinoma.
Transmigration of human ovarian adenocarcinoma cells through endothelial extracellular matrix involves alphav integrins and the participation of MMP2.
Tumor cell-matrix interaction: pericellular matrix degradation and metastasis.
Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.
Upregulated expression and activation of membrane?associated proteases in esophageal squamous cell carcinoma.
Visual and automated assessment of matrix metalloproteinase-14 tissue expression for the evaluation of ovarian cancer prognosis.
[Correlation of membrane type I matrix metalloproteinase (MT1-MMP) expression with clinicomorphological features of tumor front in squamous cell carcinoma of the larynx]
[Effect of bone morphogenetic protein-2 on the expression of membrane Type 1-matrix metalloproteinase in human A549 lung carcinoma cells]
[Expression levels of MMP-14, ING4 and HIF-1? in 60 patients with oral squamous cell carcinoma and their clinical significance].
[Expression of matrix metalloproteinase 1 in tissue of colon carcinoma and its clinical prognostic significance].
[Expression of MMP1 mRNA in oral squamous cell carcinoma and paired normal tissues]
[Expression of MT1-MMP and RECK protein in human gastric carcinoma].
[Expression pattern of membrane type-1 matrix metalloproteinase in primary breast carcinomas].
[Inhibitory effect of MT1-MMP antisense nucleotide on invasion of human highly metastatic ovarian cancer cell line SW626.]
[Interstitial collagenase, gelatinases A and B and their endogenous inhibitors in squamous cell cervical carcinomas].
[Morphological tumor front grading and matrix metalloproteinases type I expression as a prognostic parameter of the presence of lymph node micrometastases in laryngeal carcinoma]
[Significance of membrane type-1 matrix metalloproteinase expression in breast cancer]
[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].
Carcinoma in Situ
Changes in the expression of matrix proteases and of the transcription factor c-Ets-1 during progression of precancerous bronchial lesions.
Carcinoma, Basal Cell
Enhanced collagenase production by fibroblasts derived from human basal cell carcinomas.
Increased immunoreactivity of MT1-MMP and beta-catenin in high risk basal cell carcinoma.
Protein Expression of MMP-2 and MT1-MMP in Actinic Keratosis, Squamous Cell Carcinoma of the Skin, and Basal Cell Carcinoma.
Stimulation of skin fibroblast collagenase production by a cytokine derived from basal cell carcinomas.
Carcinoma, Ductal
Expression of MMP-2 and MMP-9, their inhibitors, and the activator MT1-MMP in primary breast carcinomas.
Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in ductal carcinoma in situ and invasive ductal carcinoma of the breast.
Carcinoma, Endometrioid
Prognostic significance of stromal metalloproteinase-2 in ovarian adenocarcinoma and its relation to carcinoma progression.
Carcinoma, Hepatocellular
Analysis of matrix metalloproteinase mRNAs expressed in hepatocellular carcinoma cell lines.
Assessing matrix metalloproteinase expression and activity in hepatocellular carcinomas.
Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (MT-MMPs) in association with MMP2 activation in injured human livers.
Dual functions of ARP101 in targeting membrane type-1 matrix metalloproteinase: Impact on U87 glioblastoma cell invasion and autophagy signaling.
Expression of matrix metalloproteinases (MMPs) in cultured hepatocellular carcinoma (HCC) cells and surgically resected HCC tissues.
Hepatocarcinoma cell lines down-regulate matrix metalloproteinase-2 expression in human hepatic myofibroblasts.
Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas.
Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells.
Matrix Metalloproteinase 1 as a Novel Biomarker for Monitoring Hepatocellular Carcinoma in Liver Transplant Patients.
Membrane palmitoylated protein 3 promotes hepatocellular carcinoma cell migration and invasion via up-regulating matrix metalloproteinase 1.
Membrane-type matrix metalloproteinase-1(MT1-MTP) gene is overexpressed in highly invasive hepatocellular carcinomas.
Overexpression of MT3-MMP in hepatocellular carcinoma correlates with capsular invasion.
Ribozyme mediated suppression of vascular endothelial growth factor gene expression enhances matrix metalloproteinase 1 expression in a human hepatocellular carcinoma cell line.
The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression.
[Expression of MT1-MMP and its significance in rabbit VX2 tumor tissues after transarterial embolization with hydroxyapatite nanoparticles]
Carcinoma, Intraductal, Noninfiltrating
Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events.
Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in ductal carcinoma in situ and invasive ductal carcinoma of the breast.
Immunohistochemical study of matrix metalloproteinase 9 and tissue inhibitor of matrix metalloproteinase 1 in benign and malignant breast tissue--strong expression in intraductal carcinomas of the breast.
Carcinoma, Large Cell
Expression of c-ets-1, collagenase 1, and urokinase-type plasminogen activator genes in lung carcinomas.
Carcinoma, Lewis Lung
Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.
Carcinoma, Lobular
Expression of MMP-2 and MMP-9, their inhibitors, and the activator MT1-MMP in primary breast carcinomas.
Carcinoma, Neuroendocrine
Expression of c-ets-1, collagenase 1, and urokinase-type plasminogen activator genes in lung carcinomas.
Carcinoma, Non-Small-Cell Lung
Insufficient CD100 shedding contributes to suppression of CD8+ T cell activity in non-small cell lung cancer.
Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: correlation of MMP-14 mRNA expression and proteolytic activity.
MMP-14 overexpression correlates with poor prognosis in non-small cell lung cancer.
Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer.
Prognostic significance of stromal metalloproteinase-2 in ovarian adenocarcinoma and its relation to carcinoma progression.
Carcinoma, Papillary
MT1-MMP and MMP-7 in invasion and metastasis of human cancers.
Carcinoma, Renal Cell
Expression of messenger RNAs for membrane-type 1, 2, and 3 matrix metalloproteinases in human renal cell carcinomas.
Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype.
mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas.
Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy.
The Precise Diagnosis of Cancer Invasion/Metastasis via 2D Laser Ablation Mass Mapping of Metalloproteinase in Primary Cancer Tissue.
Carcinoma, Squamous Cell
Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2.
Basic fibroblast growth factor: a missing link between collagen VII, increased collagenase, and squamous cell carcinoma in recessive dystrophic epidermolysis bullosa.
Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx.
Differential stromal regulation of MMP-1 expression in benign and malignant keratinocytes.
Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck.
E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters.
EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma.
Expression of c-ets-1, collagenase 1, and urokinase-type plasminogen activator genes in lung carcinomas.
Expression of collagenase-1 (MMP-1), collagenase-3 (MMP-13) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in laryngeal squamous cell carcinomas.
Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1 (MT1-MMP): a systemic whole cell analysis of MT1-MMP-associating proteins in A431 cells.
Immunohistochemical demonstration of EphA2 processing by MT1-MMP in invasive cutaneous squamous cell carcinoma.
Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas.
Interstitial collagenase gene expression in oral squamous cell carcinoma.
Interstitial collagenase MMP-1 and EMMPRIN in cell lines and in clinical specimens of cervical squamous cell carcinoma.
Matrix metalloproteinase 1: a better biomarker for squamous cell carcinoma by multiple microarray analyses.
Matrix metalloproteinase-2 and -14 in p16-positive and -negative HNSCC after exposure To 5-FU and docetaxel In Vitro.
MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines.
MMP-2 and TIMP-2 expression correlates with poor prognosis in cervical carcinoma--a clinicopathologic study using immunohistochemistry and mRNA in situ hybridization.
Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth.
Protein Expression of MMP-2 and MT1-MMP in Actinic Keratosis, Squamous Cell Carcinoma of the Skin, and Basal Cell Carcinoma.
[Correlation of membrane type I matrix metalloproteinase (MT1-MMP) expression with clinicomorphological features of tumor front in squamous cell carcinoma of the larynx]
[Interstitial collagenase, gelatinases A and B and their endogenous inhibitors in squamous cell cervical carcinomas].
[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].
Carcinoma, Transitional Cell
Expression of matrix metalloproteinase-2 (MMP-2) and of membrane-type-1-matrix metalloproteinase (MT1-MMP) in transitional cell carcinoma of the upper urinary tract.
Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder.
Carcinoma, Verrucous
Evaluation of the presence of myofibroblasts and matrix metalloproteinase 1 expression in the stroma of oral verrucous hyperplasia and verrucous carcinoma.
Cardiomyopathy, Dilated
A matrix metalloproteinase induction/activation system exists in the human left ventricular myocardium and is upregulated in heart failure.
PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts.
Cardiovascular Diseases
Anti-apolipoprotein A-1 IgG predicts major cardiovascular events in patients with rheumatoid arthritis.
MEMBRANE TYPE 1-MATRIX METALLOPROTEINASE (MT1-MMP) IDENTIFIED AS A MULTIFUNCTIONAL REGULATOR OF VASCULAR RESPONSES.
Carotid Artery Diseases
Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis.
Carotid Artery Injuries
TGF-?1/Smad signaling, MMP-14, and MSC markers in arterial injury: discovery of the molecular basis of restenosis.
Cerebellar Ataxia
Exclusion of stromelysin-1, stromelysin-2, interstitial collagenase and fibronectin genes as the mutant loci in a family with recessive epidermolysis bullosa dystrophica and a form of cerebellar ataxia.
Cerebral Infarction
[Association of MMP-14 gene polymorphism with cerebral infarction - a case-control study].
Cervical Intraepithelial Neoplasia
MMP-2 and TIMP-2 expression correlates with poor prognosis in cervical carcinoma--a clinicopathologic study using immunohistochemistry and mRNA in situ hybridization.
Cholangiocarcinoma
Expression of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts.
Cholecystitis
Expression of matrix metalloproteinases in gallbladder carcinoma and their significance in carcinogenesis.
Choledochal Cyst
Expression of matrix metalloproteinase 1 and 2 in congenital choledochal cyst and its clinical significance.
Cholera
Elevated cyclic AMP suppresses ConA-induced MT1-MMP expression in MDA-MB-231 human breast cancer cells.
Cholestasis
Increased MMP-7 expression in biliary epithelium and serum underpins native liver fibrosis after successful portoenterostomy in biliary atresia.
Cholesteatoma
Evaluation of significant gene expression changes in congenital and acquired cholesteatoma.
Localization of matrix metalloproteinase 1 in cholesteatoma and deep meatal skin.
Chondroma
Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma.
Chondrosarcoma
Absence of a correlation between the presence of a single nucleotide polymorphism in the matrix metalloproteinase 1 promoter and outcome in patients of chondrosarcoma.
Apoptosis signal-regulating kinase 1 is involved in brain-derived neurotrophic factor (BDNF)-enhanced cell motility and matrix metalloproteinase 1 expression in human chondrosarcoma cells.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas.
Expression of membrane type 1 matrix metalloproteinase in human articular cartilage.
Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma.
Hyaluronan inhibits IL-1beta-stimulated collagenase production via down-regulation of phosphorylated p38 in SW-1353 human chondrosarcoma cells.
Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3.
Marshall Urist Award. Interstitial collagenase gene expression correlates with in vitro invasion in human chondrosarcoma.
MicroRNA?10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain?derived neurotrophic factor.
Chondrosarcoma, Mesenchymal
Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma.
Choriocarcinoma
Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma.
Chronic Periodontitis
CD40 engagement modulates the production of matrix metalloproteinases by gingival fibroblasts.
Characteristics of collagenase-2 from gingival crevicular fluid and peri-implant sulcular fluid in periodontitis and peri-implantitis patients: pilot study.
Tetracycline inhibition identifies the cellular origin of interstitial collagenases in human periodontal diseases in vivo.
Colitis
"Splitting the matrix": intussusceptive angiogenesis meets MT1-MMP.
Endothelial MT1-MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis.
Colitis, Collagenous
Fibrogenesis and fibrolysis in collagenous colitis. Patterns of procollagen types I and IV, matrix-metalloproteinase-1 and -13, and TIMP-1 gene expression.
Colitis, Ulcerative
Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?
Colonic Neoplasms
Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor.
Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity.
miR-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Metalloproteinase-14.
Overexpression of MT1-MMP is insufficient to increase experimental liver metastasis of human colon cancer cells.
The clinical significance and biological function of tropomyosin 4 in colon cancer.
Colorectal Neoplasms
?-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness.
Beta-catenin activates a coordinated expression of the proinvasive factors laminin-5 gamma2 chain and MT1-MMP in colorectal carcinomas.
Clinicopathological and Prognostic Significance of ?5?1-integrin and MMP-14 Expressions in Colorectal Cancer.
Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from colorectal cancer.
Expression and localization of membrane-type-1 matrix metalloproteinase, CD 44, and laminin-5gamma2 chain during colorectal carcinoma tumor progression.
Imatinib inhibits colorectal cancer cell growth and suppresses stromal-induced growth stimulation, MT1-MMP expression and pro-MMP2 activation.
Immunohistochemical detection of membrane-type-1-matrix metalloproteinase in colorectal carcinoma.
Low collagenase-1 (MMP-1) and MT1-MMP expression levels are favourable survival markers in advanced colorectal carcinoma.
Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
Matrix metalloproteinases may contribute compensationally to tumor invasion in T1 colorectal carcinomas.
Plasma concentration of tissue inhibitor of matrix metalloproteinase 1 in patients with colorectal carcinoma.
Preanalytical Interferences Compromise the Clinical Validity of Matrix Metalloproteinase 1 as Marker of Colorectal Cancer.
Profiling markers of prognosis in colorectal cancer.
Prophylactical Low Dose Whole-Liver Irradiation Inhibited Colorectal Liver Metastasis by Regulating Hepatic Niche in Mice.
Relation of MT1-MMP gene expression to outcomes in colorectal cancer.
Reply: Preanalytical Interferences Compromise the Clinical Validity of Matrix Metalloproteinase 1 as Marker of Colorectal Cancer.
Role of matrix metalloproteinases (MMPs) in colorectal cancer.
Serum Matrix-Metalloproteinase-1 is a Bona Fide Prognostic Marker for Colorectal Cancer.
The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer.
The distribution of matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal cancer.
[Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal neoplasm]
[Implication of VEGF and MMPs in hepatic metastasis of human colon cancer]
[Role of CD44 and MT1-MMP in colorectal cancer invasion and metastasis]
Connective Tissue Diseases
Integration of the NF-kappaB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts.
Corneal Diseases
Collagenase (MMP-1) and TIMP-1 in destructive corneal disease associated with rheumatoid arthritis.
Corneal Neovascularization
Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis).
Matrix metalloproteinase 14 modulates signal transduction and angiogenesis in the cornea.
Membrane type-1 matrix metalloproteinase potentiates basic fibroblast growth factor-induced corneal neovascularization.
MT1-MMP cleavage of the antiangiogenic proteoglycan decorin: role in corneal angiogenesis.
MT1-MMP Cleavage of the Antiangiogenic Proteoglycan Decorin: Role in Corneal Angiogenesis: Retraction.
Coronary Artery Disease
Circumferential stress and matrix metalloproteinase 1 in human coronary atherosclerosis. Implications for plaque rupture.
Craniofacial Abnormalities
Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice.
MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.
Crohn Disease
Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?
Relationship between Metalloprotease-7 and -14 and Tissue Inhibitor of Metalloprotease 1 Expression by Mucosal Stromal Cells and Colorectal Cancer Development in Inflammatory Bowel Disease.
Cysts
Effect of dental cyst epithelium-conditioned medium on collagenase production by periodontal ligament fibroblasts.
Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease.
Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells.
Membrane-type-1 matrix metalloproteinase confers tumorigenicity on nonmalignant epithelial cells.
Modulation of Matrix Metalloproteinase 14, Tissue Inhibitor of Metalloproteinase 3, Tissue Inhibitor of Metalloproteinase 4, and Inducible Nitric Oxide Synthase in the Development of Periapical Lesions.
The hemopexin domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) Is not required for its activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen.
Demyelinating Diseases
Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.
Dermatitis Herpetiformis
Enhanced expression of interstitial collagenase, stromelysin-1, and urokinase plasminogen activator in lesions of dermatitis herpetiformis.
Urokinase plasminogen activator is expressed by basal keratinocytes before interstitial collagenase, stromelysin-1, and laminin-5 in experimentally induced dermatitis herpetiformis lesions.
Dermatitis, Contact
Monocyte/Macrophage MMP-14 Modulates Cell Infiltration and T-Cell Attraction in Contact Dermatitis But Not in Murine Wound Healing.
Dermatomyositis
Expression of specific matrix metalloproteinases in inflammatory myopathies.
Diabetes Mellitus, Type 1
Defining the roles of T cell membrane proteinase and CD44 in type 1 diabetes.
Matrix metalloproteinases, T cell homing and beta-cell mass in type 1 diabetes.
Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes.
MT1-MMP expression in first-trimester placental tissue is upregulated in type 1 diabetes as a result of elevated insulin and tumor necrosis factor-alpha levels.
Targeting the T-cell membrane type-1 matrix metalloproteinase-CD44 axis in a transferred type 1 diabetes model in NOD mice.
The skin remodeling in type 1 diabetes and insulin resistance animal models.
Diabetes Mellitus, Type 2
Tissue inhibitor matrix metalloproteinase 1 and risk of type 2 diabetes in a Chinese population.
Diabetes, Gestational
Fetal Insulin and IGF-II Contribute to Gestational Diabetes Mellitus (GDM)-Associated Up-Regulation of Membrane-Type Matrix Metalloproteinase 1 (MT1-MMP) in the Human Feto-Placental Endothelium.
Diabetic Angiopathies
MEMBRANE TYPE 1-MATRIX METALLOPROTEINASE (MT1-MMP) IDENTIFIED AS A MULTIFUNCTIONAL REGULATOR OF VASCULAR RESPONSES.
Diabetic Nephropathies
Collagenase-1 (-1607 1G/2G), Gelatinase-A (-1306 C/T), Stromelysin-1 (-1171 5A/6A) functional promoter polymorphisms in risk prediction of type 2 diabetic nephropathy.
Matrix metalloproteinase-2 (MMP-2) and membrane-type 1 MMP (MT1-MMP) affect the remodeling of glomerulosclerosis in diabetic OLETF rats.
Diabetic Retinopathy
Matrix metalloproteinase-14 is a biomarker of angiogenic activity in proliferative diabetic retinopathy.
Distemper
Up-regulation of mRNA for matrix metalloproteinases-9 and -14 in advanced lesions of demyelinating canine distemper leukoencephalitis.
Diverticular Diseases
Increased distribution of collagen type III and reduced expression of matrix metalloproteinase 1 in patients with diverticular disease.
Diverticulum
Genetic variants of tissue inhibitors of matrix metalloproteinase 1 (rs4898) and 2 (rs8179090) in diverticulosis.
Down Syndrome
Enhancement of matrix metalloproteinase (MMP)-2 activity in gingival tissue and cultured fibroblasts from Down's syndrome patients.
Dupuytren Contracture
A common SNP risk variant MT1-MMP causative for Dupuytren's disease has a specific defect in collagenolytic activity.
MMP-14 and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction.
Dwarfism
Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice.
Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism.
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover.
Dysplastic Nevus Syndrome
Coordinate expression of membrane type-matrix metalloproteinases-2 and 3 (MT2-MMP and MT3-MMP) and matrix metalloproteinase-2 (MMP-2) in primary and metastatic melanoma cells.
Encephalitis
Up-regulation of mRNA for matrix metalloproteinases-9 and -14 in advanced lesions of demyelinating canine distemper leukoencephalitis.
Endometrial Hyperplasia
Localization of MT1-MMP, TIMP-1, TIMP-2, and TIMP-3 messenger RNA in normal, hyperplastic, and neoplastic endometrium. Enhanced expression by endometrial adenocarcinomas is associated with low differentiation.
Endometrial Neoplasms
Presence of active gelatinases in endometrial carcinoma and correlation of matrix metalloproteinase expression with increasing tumor grade and invasion.
Progesterone and calcitriol reduce invasive potential of endometrial cancer cells by targeting ARF6, NEDD9 and MT1-MMP.
RNA interference screening identifies clathrin-B and cofilin-1 as mediators of MT1-MMP in endometrial cancer.
SPOCK2 Affects the Biological Behavior of Endometrial Cancer Cells by Regulation of MT1-MMP and MMP2.
Tumor cell-matrix interaction: pericellular matrix degradation and metastasis.
Endometriosis
Analysis of two polymorphisms in the promoter region of matrix metalloproteinase 1 and 3 genes in women with endometriosis.
Estrogen receptor beta and matrix metalloproteinase 1 are coexpressed in uterine endometrium and endometriotic lesions of patients with endometriosis.
Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions.
Matrix metalloproteinase messenger RNA expression in human endometriosis grafts cultured on a chicken chorioallantoic membrane.
Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium.
Endotoxemia
Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia.
Roles of MMP-2/-9 in cardiac dysfunction during early multiple organ failure in an ovine animal model.
Epidermolysis Bullosa
[Fibroblast collagenase activity in some types of inherited epidermolysis bullosa]
Epidermolysis Bullosa Dystrophica
Basic fibroblast growth factor: a missing link between collagen VII, increased collagenase, and squamous cell carcinoma in recessive dystrophic epidermolysis bullosa.
Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin.
Exclusion of stromelysin-1, stromelysin-2, interstitial collagenase and fibronectin genes as the mutant loci in a family with recessive epidermolysis bullosa dystrophica and a form of cerebellar ataxia.
Epiretinal Membrane
Matrix metalloproteinase-14 is a biomarker of angiogenic activity in proliferative diabetic retinopathy.
Predominance of MMP-1 and MMP-2 in epiretinal and subretinal membranes of proliferative vitreoretinopathy.
Esophageal Neoplasms
Downregulation of RIKP by miR-200a promotes the invasive ability of esophageal cancer cells by upregulating the expression of LIN28 and MMP-14 [Retraction].
Downregulation of RIKP by miR-200a promotes the invasive ability of esophageal cancer cells by upregulating the expression of LIN28 and MMP-14.
Raf kinase inhibitor protein inhibits esophageal cancer cell invasion through downregulation of matrix metalloproteinase expression.
Upregulated expression and activation of membrane?associated proteases in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Differential expression of MMP and uPA systems and prognostic relevance of their expression in esophageal squamous cell carcinoma.
Interaction of MT1-MMP and laminin-5gamma2 chain correlates with metastasis and invasiveness in human esophageal squamous cell carcinoma.
Matrix metalloproteinase 1, 3, and 9 polymorphisms and esophageal squamous cell carcinoma risk.
Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation.
MT3-MMP down-regulation promotes tumorigenesis and correlates to poor prognosis in esophageal squamous cell carcinoma.
No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China.
Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma.
Upregulated expression and activation of membrane?associated proteases in esophageal squamous cell carcinoma.
Fasciculation
Regulatory network of differentially expressed genes in metastatic osteosarcoma.
Fetal Growth Retardation
Matrix metalloproteinase 1 in pre-eclampsia and fetal growth restriction: reduced gene expression in decidual tissue and protein expression in extravillous trophoblasts.
Membrane-Type Matrix Metalloproteinase 1 (MT1-MMP) Regulates Trophoblast Functions and Is Reduced in Fetal Growth Restriction.
Fibromatosis, Aggressive
Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP.
Fibrosarcoma
(-)Epigallocatechin-3-gallate directly inhibits MT1-MMP activity, leading to accumulation of nonactivated MMP-2 at the cell surface.
1-furan-2-yl-3-pyridin-2-yl-propenone inhibits the invasion and migration of HT1080 human fibrosarcoma cells through the inhibition of proMMP-2 activation and down regulation of MMP-9 and MT1-MMP.
A specific sequence of the noncollagenous domain of the alpha3(IV) chain of type IV collagen inhibits expression and activation of matrix metalloproteinases by tumor cells.
A Transcriptional Regulatory Role for the Membrane Type-1 Matrix Metalloproteinase in Carcinogen-Induced Inflammasome Gene Expression.
Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells.
An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy.
Biochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cells.
Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar.
Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration.
CMT-3, a non-antimicrobial tetracycline (TC), inhibits MT1-MMP activity: relevance to cancer.
Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo.
Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).
Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells.
Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts.
Dual-functions of miR-373 and miR-520c by differently regulating the activities of MMP2 and MMP9.
GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase.
Heat shock suppresses membrane type 1-matrix metalloproteinase production and progelatinase A activation in human fibrosarcoma HT-1080 cells and thereby inhibits cellular invasion.
Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression.
Impaired tyrosine phosphorylation of membrane type 1-matrix metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates tumor growth in mice.
Increased E1AF expression in mouse fibrosarcoma promotes metastasis through induction of MT1-MMP expression.
Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors.
Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains.
Mapping proteolytic cancer cell-extracellular matrix interfaces.
Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion.
Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface.
MT1-MMP prevents growth inhibition by three dimensional fibronectin matrix.
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion.
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells.
Neutrophil-derived serine proteinases enhance membrane type-1 matrix metalloproteinase-dependent tumor cell invasion.
Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells.
Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinase.
Phagocytosis of collagen by fibroblasts and invasive cancer cells is mediated by MT1-MMP.
Phosphorylation of membrane type 1-matrix metalloproteinase (MT1-MMP) and its vesicle-associated membrane protein 7 (VAMP7)-dependent trafficking facilitate cell invasion and migration.
Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface.
Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes.
Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy.
The activation of ProMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP-14) to a 45 kDa form.
The C-terminal domain of tissue inhibitor of metalloproteinases-2 is required for cell binding but not for antimetalloproteinase activity.
The Oncogenic Response to MiR-335 Is Associated with Cell Surface Expression of Membrane-Type 1 Matrix Metalloproteinase (MT1-MMP) Activity.
The role of MT2-MMP in cancer progression.
TIMP-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells.
Gastritis
Serum Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) mRNA Protected by Exosomes as a Potential Biomarker for Gastric Cancer.
Gastrointestinal Neoplasms
Gene expression of interstitial collagenase (matrix metalloproteinase 1) in gastrointestinal tract cancers.
Gingival Pocket
Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation.
Gingivitis
Characteristics of collagenase-2 from gingival crevicular fluid and peri-implant sulcular fluid in periodontitis and peri-implantitis patients: pilot study.
Glaucoma
Differential expression of matrix metalloproteinases in monkey eyes with experimental glaucoma or optic nerve transection.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes.
Glioblastoma
A role for MT1-MMP as a cell death sensor/effector through the regulation of endoplasmic reticulum stress in U87 glioblastoma cells.
Arsenic Trioxide Induces Apoptosis and Incapacitates Proliferation and Invasive Properties of U87MG Glioblastoma Cells through a Possible NF-?B-Mediated Mechanism.
Biophysical evidence for differential gallated green tea catechins binding to membrane type-1 matrix metalloproteinase and its interactors.
Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation.
Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells.
Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression.
Dual functions of ARP101 in targeting membrane type-1 matrix metalloproteinase: Impact on U87 glioblastoma cell invasion and autophagy signaling.
Dual-functions of miR-373 and miR-520c by differently regulating the activities of MMP2 and MMP9.
Epigenetic Control of the Invasion-promoting MT1-MMP/MMP-2/TIMP-2 Axis in Cancer Cells.
Evidence of MTCBP-1 interaction with the cytoplasmic domain of MT1-MMP: Implications in the autophagy cell index of high-grade glioblastoma.
Expression and tissue localization of membrane-type 1, 2, and 3 matrix metalloproteinases in human astrocytic tumors.
Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors.
Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells.
Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells.
Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains.
Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression.
Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matter.
Modulation of invasive properties of CD133(+) glioblastoma stem cells: A role for MT1-MMP in bioactive lysophospholipid signaling.
Necrosis induction in glioblastoma cells reveals a new "bioswitch" function for the MT1-MMP/G6PT signaling axis in proMMP-2 activation versus cell death decision.
New photodynamic molecular beacons (PMB) as potential cancer-targeted agents in PDT.
Protein kinase C activation by phorbol ester increases in vitro invasion through regulation of matrix metalloproteinases/tissue inhibitors of metalloproteinases system in D54 human glioblastoma cells.
Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma.
Targeting the MMP-14/MMP-2/integrin ?v?3 axis with multispecific N-TIMP2-based antagonists for cancer therapy.
The Oncogenic Response to MiR-335 Is Associated with Cell Surface Expression of Membrane-Type 1 Matrix Metalloproteinase (MT1-MMP) Activity.
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway.
Tumor cell-matrix interaction: pericellular matrix degradation and metastasis.
Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line.
Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas.
[Increased expression of gelatinases A and B, matrilysin and TIMP-1 genes in human malignant gliomas ]
Glioma
A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells.
Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2.
Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression.
Centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis.
Co-expression of MMP-14 and MMP-19 predicts poor survival in human glioma.
Discriminating healthy from tumor and necrosis tissue in rat brain tissue samples by Raman spectral imaging.
Enolase-phosphatase 1 as a novel potential malignant glioma indicator promotes cell proliferation and migration.
Expressions of matrix metalloproteinase-7 and matrix metalloproteinase-14 associated with the activation of extracellular signal-regulated kinase1/2 in human brain gliomas of different pathological grades.
Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas.
Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling.
Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1.
Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion.
In vivo imaging of membrane type-1 matrix metalloproteinase with a novel activatable near-infrared fluorescence probe.
Induction of matrix metalloproteinase-1 and glioma cell motility by nitric oxide.
Induction of membrane-type-1 matrix metalloproteinase by epidermal growth factor-mediated signaling in gliomas.
KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP.
Long Non-coding RNA LINC00339 Stimulates Glioma Vasculogenic Mimicry Formation by Regulating the miR-539-5p/TWIST1/MMPs Axis.
Matrix metalloproteinase 1 is necessary for the migration of human bone marrow-derived mesenchymal stem cells toward human glioma.
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas.
Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression.
Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion.
Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matter.
Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10.
Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression.
miR-150-5p and miR-133a suppress glioma cell proliferation and migration through targeting membrane-type-1 matrix metalloproteinase.
MT1-MMP and MMP-7 in invasion and metastasis of human cancers.
Neurokinin-1 receptor directly mediates glioma cell migration by up-regulation of matrix metalloproteinase-2 (MMP-2) and membrane type 1-matrix metalloproteinase (MT1-MMP).
NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-?B pathway.
Probing the infiltrating character of brain tumors: inhibition of RhoA/ROK-mediated CD44 cell surface shedding from glioma cells by the green tea catechin EGCg.
Protein kinase C-mediated in vitro invasion of human glioma cells through extracellular-signal-regulated kinase and ornithine decarboxylase.
Rapid activation of matrix metalloproteinase-2 by glioma cells occurs through a posttranslational MT1-MMP-dependent mechanism.
SPARC upregulates MT1-MMP expression, MMP-2 activation, and the secretion and cleavage of galectin-3 in U87MG glioma cells.
Targeting MMP-14 for dual PET and fluorescence imaging of glioma in preclinical models.
Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas.
The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKKgamma/NF-kappaB-dependent pathway.
The value and correlation between PRL-3 expression and matrix metalloproteinase activity and expression in human gliomas.
Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.
Tumor cell-matrix interaction: pericellular matrix degradation and metastasis.
Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma.
Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis.
Glomerulonephritis
Characterization of the transcriptional regulation of the human MT1-MMP gene and association of risk reduction for focal-segmental glomerulosclerosis with two functional promoter SNPs.
Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis.
Macrophage-derived MT1-MMP and increased MMP-2 activity are associated with glomerular damage in crescentic glomerulonephritis.
Granuloma
Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing.
Cellular source of collagenase and TIMP-1 in carrageenin-induced granuloma.
Collagenase-3 induction in rat lung fibroblasts requires the combined effects of tumor necrosis factor-alpha and 12-lipoxygenase metabolites: a model of macrophage-induced, fibroblast-driven extracellular matrix remodeling during inflammatory lung injury.
Interstitial collagenase (MMP-1), gelatinase (MMP-2) and stromelysin (MMP-3) released by human fibroblasts cultured on acellular sarcoid granulomas (sarcoid matrix complex, SMC).
Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis.
Granuloma Annulare
Expression of interstitial collagenase, 92-kDa gelatinase, and tissue inhibitor of metalloproteinases-1 in granuloma annulare and necrobiosis lipoidica diabeticorum.
Hajdu-Cheney Syndrome
Mutation of Membrane Type-1 Metalloproteinase, MT1-MMP, Causes the Multicentric Osteolysis and Arthritis Disease Winchester Syndrome.
Hearing Loss
MMP-14 (MT1-MMP) Is a Biomarker of Surgical Outcome and a Potential Mediator of Hearing Loss in Patients With Vestibular Schwannomas.
Heart Failure
Controlled Release of Matrix Metalloproteinase 1 with or wiyhout Skeletal Myoblasts Transplantion Improves Cardiac Function of Rat Hearts with Chronic Myocardial Infarction.
Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat.
Metalloproteinase expression is altered in cardiac and skeletal muscle in cancer cachexia.
Hepatitis
Tissue inhibitor of metalloproteinase-I and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes.
Hepatitis C, Chronic
Longitudinal evaluation of a fibrosis index combining MMP-1 and PIIINP compared with MMP-9, TIMP-1 and hyaluronic acid in patients with chronic hepatitis C treated by interferon-alpha and ribavirin.
Hepatitis, Chronic
Tissue inhibitor of metalloproteinase-I and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes.
Histiocytic Sarcoma
Matrix metalloproteinases expression in spontaneous canine histiocytic sarcomas and its xenograft model.
Histiocytoma, Malignant Fibrous
Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP.
Histiocytosis, Sinus
Expressions of extracellular matrix-remodeling factors in lymph nodes from oral cancer patients.
Hydrocephalus
MT1-MMP deficiency leads to defective ependymal cell maturation, impaired ciliogenesis, and hydrocephalus.
Hyperalgesia
Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.
Hyperglycemia
Fetal Insulin and IGF-II Contribute to Gestational Diabetes Mellitus (GDM)-Associated Up-Regulation of Membrane-Type Matrix Metalloproteinase 1 (MT1-MMP) in the Human Feto-Placental Endothelium.
Hyperlipidemias
Cleavage and functional loss of human apolipoprotein E by digestion of matrix metalloproteinase-14.
Hyperostosis
Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas.
Hypersensitivity
Transcriptional repression of the human collagenase-1 (MMP-1) gene in MDA231 breast cancer cells by all-trans-retinoic acid requires distal regions of the promoter.
Hypertension
Downregulation of vascular matrix metalloproteinase inducer and activator proteins in hypertensive patients.
Effects of early and late chronic pressure overload on extracellular matrix remodeling.
Estrogen deficiency-induced alterations of vascular MMP-2, MT1-MMP, and TIMP-2 in ovariectomized rats.
Estrogen effects on MMP-13 and MMP-14 regulation of left ventricular mass in Dahl salt-induced hypertension.
Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension.
[Association of MMP-14 gene polymorphism with cerebral infarction - a case-control study].
Hypertension, Pulmonary
Acute and chronic hypoxia as well as 7-day recovery from chronic hypoxia affects the distribution of pulmonary mast cells and their MMP-13 expression in rats.
Hypertrophy, Left Ventricular
Leukocyte matrix metalloproteinase and tissue inhibitor gene expression patterns in children with primary hypertension.
Infections
Assay of extracellular matrix degradation and transmigration of chicken peripheral blood mononuclear cells after infection with genotype VII Newcastle disease virus in vitro.
Balance between polyoma enhancing activator 3 and activator protein 1 regulates Helicobacter pylori-stimulated matrix metalloproteinase 1 expression.
Expression of a progelatinase activator (MT1-MMP) in human fetal membranes.
Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality.
Interaction between hepatic membrane type 1 matrix metalloproteinase and acireductone dioxygenase 1 regulates hepatitis C virus infection.
Matrix metalloproteinase 14 regulates HSV-1 infection in neuroblastoma cells.
Matrix metalloproteinase-14 regulates collagen degradation and migration of mononuclear cells during infection with genotype VII Newcastle disease virus.
Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis.
MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy.
Rapid Proteome Changes in Plasma and Cerebrospinal Fluid Following Bacterial Infection in Preterm Newborn Pigs.
Transforming growth factor-beta induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase.
Virus-Mediated Metalloproteinase 1 Induction Revealed by Transcriptome Profiling of Bovine Herpesvirus 4-Infected Bovine Endometrial Stromal Cells.
Inflammatory Bowel Diseases
Endothelial MT1-MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis.
Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?
Ligation of alpha4ss1 integrin on human intestinal mucosal mesenchymal cells selectively Up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotype.
Inflammatory Breast Neoplasms
Membrane type-1 matrix metalloproteinase (MT1-MMP) correlates with the expression and activation of matrix metalloproteinase-2 (MMP-2) in inflammatory breast cancer.
Influenza, Human
Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality.
Insulin Resistance
The skin remodeling in type 1 diabetes and insulin resistance animal models.
interstitial collagenase deficiency
Correction to: Effect of MT1-MMP deficiency and overexpression in corneal keratocytes on vascular endothelial cell migration and proliferation.
Effect of MT1-MMP deficiency and overexpression in corneal keratocytes on vascular endothelial cell migration and proliferation.
Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques.
MT1-MMP and Type II Collagen Specify Skeletal Stem Cells and Their Bone and Cartilage Progeny.
MT1-MMP deficiency leads to defective ependymal cell maturation, impaired ciliogenesis, and hydrocephalus.
MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing.
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover.
MT1-MMP-dependent, apoptotic remodeling of unmineralized cartilage: a critical process in skeletal growth.
Multifunctional roles of MT1-MMP in myofiber formation and morphostatic maintenance of skeletal muscle.
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis.
Intervertebral Disc Degeneration
Genetic Dimension of Intervertebral Disc Degeneration: Polymorphism of Matrix Metalloproteinase 1 and 3 in the North Iranian Population.
Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels.
[Effect of Acupotomy Lysis at Cervical Acupoints on Expression of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinase 1 and Changes of Pulpiform Nucleus Ultrastructure in Rats with Degenerated Cervical Intervertebral Discs].
Intervertebral Disc Displacement
Expression of Matrix Metalloproteinases is Positively Related to the Severity of Disc Degeneration and Growing Age in the East Asian Lumbar Disc Herniation Patients.
The relation of matrix metalloproteinase 1, 2, 3 expressions with clinical and radiological findings in primary and recurrent lumbar disc herniations.
Ischemic Attack, Transient
Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia.
Jaw Cysts
Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate).
Joint Diseases
Characterisation of the cell type-specificity of collagenase 3 mRNA expression in comparison with membrane type 1 matrix metalloproteinase and gelatinase A in the synovial membrane in rheumatoid arthritis.
Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts.
Increased serum stromelysin-1 levels in systemic lupus erythematosus: lack of correlation with disease activity.
Keloid
Promoted activation of matrix metalloproteinase (MMP)-2 in keloid fibroblasts and increased expression of MMP-2 in collagen bundle regions: implications for mechanisms of keloid progression.
Keratoconus
Collagenolytic proteinases in keratoconus.
EMMPRIN and MMP-1 in keratoconus.
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) and MMP-2 in normal and keratoconus corneas.
Is the corneal degradation in keratoconus caused by matrix-metalloproteinases?
Keratosis, Actinic
Protein Expression of MMP-2 and MT1-MMP in Actinic Keratosis, Squamous Cell Carcinoma of the Skin, and Basal Cell Carcinoma.
Kidney Diseases
Characterization of the transcriptional regulation of the human MT1-MMP gene and association of risk reduction for focal-segmental glomerulosclerosis with two functional promoter SNPs.
Kidney Neoplasms
Membrane type-2 matrix metalloproteinases improve the progression of renal cell cancer.
Laryngeal Neoplasms
Direct cell-cell interaction enhances pro-MMP-2 production and activation in co-culture of laryngeal cancer cells and fibroblasts: involvement of EMMPRIN and MT1-MMP.
Expression of mRNA for membrane-type 1, 2, and 3 matrix metalloproteinases in human laryngeal cancer.
Leg Ulcer
Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers.
Leiomyoma
Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer.
Leukemia
Identification of novel target proteins in sebaceous gland carcinoma.
The anti-invasive activity of synthetic alkaloid ethoxyfagaronine on L1210 leukemia cells is mediated by down-regulation of plasminogen activators and MT1-MMP expression and activity.
The role of fibroblasts and fibroblast-derived factors in periprosthetic osteolysis.
[Effect of TIMP-2, MT1-MMP and MMP-2 expression on the in vitro invasive capacity of acute monocytic leukemia SHI-1 cells.]
Leukemia, Monocytic, Acute
[Effect of TIMP-2, MT1-MMP and MMP-2 expression on the in vitro invasive capacity of acute monocytic leukemia SHI-1 cells.]
Leukemia, Myeloid, Acute
Membrane Type-1 Matrix Metalloproteinase Expression in Acute Myeloid Leukemia and Its Upregulation by Tumor Necrosis Factor-?.
Lichen Planus, Oral
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus.
[The role of matrix metalloproteinases and their tissue inhibitors in oral lichen planus]
Lipodystrophy
Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism.
Liver Cirrhosis
Assessing matrix metalloproteinase expression and activity in hepatocellular carcinomas.
Collagenases and liver fibrosis.
Diagnostic potential of serum direct markers and non-invasive fibrosis models in patients with chronic hepatitis B.
Dihydromyricetin ameliorates liver fibrosis via inhibition of hepatic stellate cells by inducing autophagy and natural killer cell-mediated killing effect.
Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat.
Effects of a plasmid expressing antisense tissue inhibitor of metalloproteinase-1 on liver fibrosis in rats.
Endoplasmic reticulum oxidase 1? is critical for collagen secretion from and membrane type 1-matrix metalloproteinase levels in hepatic stellate cells.
Enhanced interstitial collagenase (matrix metalloproteinase-13) production of Kupffer cell by gadolinium chloride prevents pig serum-induced rat liver fibrosis.
Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis.
Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver.
Expression pattern of matrix metalloproteinases-13 in a rat model of alcoholic liver fibrosis.
Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis.
Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride.
Longitudinal evaluation of a fibrosis index combining MMP-1 and PIIINP compared with MMP-9, TIMP-1 and hyaluronic acid in patients with chronic hepatitis C treated by interferon-alpha and ribavirin.
Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis.
Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats.
Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets.
Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis.
Secreted matrix metalloproteinase-14 is a predictor for antifibrotic effect of IC-2-engineered mesenchymal stem cell sheets on liver fibrosis in mice.
Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis.
Tissue inhibitors of metalloproteinases: role in liver fibrosis and alcoholic liver disease.
[Gene expression of interstitial collagenase MMP-13 in progressive phase of rat liver fibrosis induced by ethanol]
[Recombinant adenovirus Ad-human matrix metalloproteinase 1 transfecting bone marrow mesenchymal stem cells of rats in vitro].
[Therapeutic effect of BMSCs with over-expressed MMP1 on liver fibrosis].
Liver Neoplasms
MT1-MMP Responsive Doxorubicin Conjugated Poly(lactic-co-glycolic Acid)/Poly(styrene-alt-maleic Anhydride) Core/Shell Microparticles for Intrahepatic Arterial Chemotherapy of Hepatic Cancer.
Lung Diseases
Matrix metalloproteinases in lung diseases.
Lung Injury
Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia.
Lung Neoplasms
An approach to studying lung cancer-related proteins in human blood.
Changes in the expression of matrix proteases and of the transcription factor c-Ets-1 during progression of precancerous bronchial lesions.
Comparative expression of matrix metalloproteinases in internal malignancies and paired cutaneous metastatic lesions.
Expression of c-ets-1, collagenase 1, and urokinase-type plasminogen activator genes in lung carcinomas.
Expression of extracellular matrix molecules in brain metastasis.
Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer.
Identification of Wnt pathway, uPA, PAI-1, MT1-MMP, S100A4 and CXCR4 associated with enhanced metastasis of human large cell lung cancer by DNA microarray.
Insufficient CD100 shedding contributes to suppression of CD8+ T cell activity in non-small cell lung cancer.
Letter regarding "MT1-MMP is not a good prognosticator of cancer survival: evidence from 11 studies" by Wu KP et al.
Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer.
Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses.
Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: correlation of MMP-14 mRNA expression and proteolytic activity.
MMP-14 overexpression correlates with poor prognosis in non-small cell lung cancer.
MMP1 rs1799750 Single Nucleotide Polymorphism and Lung Cancer Risk: A Meta-analysis.
MT1-MMP is not a good prognosticator of cancer survival: evidence from 11 studies.
Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer.
[Association of MMP1 -1607(1G>2G)single nucleotide polymorphism with susceptibility to lung cancer in Northwestern Chinese population of Han nationality]
[Expression of membrane-type I matrix metalloproteinase and its correlation with gelatinase A activation in cancer cell lines]
[MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells].
Lupus Erythematosus, Systemic
Increased serum stromelysin-1 levels in systemic lupus erythematosus: lack of correlation with disease activity.
Lyme Disease
Borrelia burgdorferi-induced expression of matrix metalloproteinases from human chondrocytes requires mitogen-activated protein kinase and Janus kinase/signal transducer and activator of transcription signaling pathways.
Lymphatic Metastasis
A role of MMP-14 in the regulation of invasiveness of nasopharyngeal carcinoma.
Analysis of MT1-MMP and MMP2 expression in human gastric cancers.
Association between immunohistochemical expression of matrix metalloproteinases and metastasis in oral squamous cell carcinoma: Systematic review and meta-analysis.
Association of BCSC-1 and MMP-14 with human breast cancer.
Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma.
Clinical significance of MT1-MMP mRNA expression in breast cancer.
Clinical significance of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric cancer.
Clinicopathological and Prognostic Significance of ?5?1-integrin and MMP-14 Expressions in Colorectal Cancer.
Decreased MT1-MMP in gastric cancer suppressed cell migration and invasion via regulating MMPs and EMT.
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis.
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas.
Expression of membrane type 1-matrix metalloproteinase in laryngeal carcinoma.
Expression of tissue levels of matrix metalloproteinases and their inhibitors in breast cancer.
Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric adenocarcinoma.
Expressions of extracellular matrix-remodeling factors in lymph nodes from oral cancer patients.
Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.
Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material.
Matrix metalloproteinase-14 expression and its prognostic value in cervical carcinoma.
Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer.
MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis.
Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth.
Prognostic value of membrane type 1 and 2 matrix metalloproteinase expression and gelatinase A activity in bladder cancer.
Serum Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) mRNA Protected by Exosomes as a Potential Biomarker for Gastric Cancer.
Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer.
The collagenase activities, interstitial collagenase and type IV collagenase, in human stomach cancer: with special reference to local spreading and lymph node metastasis.
[Significance of membrane type-1 matrix metalloproteinase expression in breast cancer]
Lymphoma
Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases.
CD26 expression on T-anaplastic large cell lymphoma (ALCL) line Karpas 299 is associated with increased expression of versican and MT1-MMP and enhanced adhesion.
Lymphoma, B-Cell
Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/?-catenin signaling pathways.
Macular Degeneration
Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium implications for age-related macular degeneration.
Medulloblastoma
Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors.
MT1-MMP expression level status dictates the in vitro action of lupeol on inflammatory biomarkers MMP-9 and COX-2 in medulloblastoma cells.
Tumor environment dictates medulloblastoma cancer stem cell expression and invasive phenotype.
Melanoma
A novel synthetic oleanane triterpenoid suppresses adhesion, migration, and invasion of highly metastatic melanoma cells by modulating gelatinase signaling axis.
A specific sequence of the noncollagenous domain of the alpha3(IV) chain of type IV collagen inhibits expression and activation of matrix metalloproteinases by tumor cells.
Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion.
Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts.
Cell membrane-associated MT1-MMP-dependent activation of pro-MMP-2 in A375 melanoma cells.
Cloning and characterization of human tumor cell interstitial collagenase.
Control of melanoma invasiveness by anticollagenolytic agents: a reappraisal of an old concept.
Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma.
Coordinate expression of membrane type-matrix metalloproteinases-2 and 3 (MT2-MMP and MT3-MMP) and matrix metalloproteinase-2 (MMP-2) in primary and metastatic melanoma cells.
Decreased expression levels of cell cycle regulators and matrix metalloproteinases in melanoma from RET-transgenic mice by single irradiation of non-equilibrium atmospheric pressure plasmas.
Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line.
Elastin-derived peptides upregulate matrix metalloproteinase-2-mediated melanoma cell invasion through elastin-binding protein.
Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression.
Expression and distribution of MMPs and TIMPs in human uveal melanoma.
Expression of collagenase-1 (MMP-1) promotes melanoma growth through the generation of active transforming growth factor-beta.
Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas.
Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene.
Expression of integrin alpha(v)beta(3) correlates with activation of membrane-type matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) in human melanoma cells in vitro and in vivo.
Expression of matrix metalloproteinase-2 and -9 and membrane-type 1 matrix metalloproteinase in melanocytic tumors of dogs and canine melanoma cell lines.
Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization.
HIF1? and HIF2? independently activate SRC to promote melanoma metastases.
High collagenase-1 expression correlates with a favourable chemoimmunotherapy response in human metastatic melanoma.
High expression levels of collagenase-1 and stromelysin-1 correlate with shorter disease-free survival in human metastatic melanoma.
High serum levels of matrix metalloproteinase-9 and matrix metalloproteinase-1 are associated with rapid progression in patients with metastatic melanoma.
High throughput analysis of proteins associating with a proinvasive MT1-MMP in human malignant melanoma A375 cells.
Human hemokinin-1 promotes migration of melanoma cells and increases MMP-2 and MT1-MMP expression by activating tumor cell NK1 receptors.
Hyaluronan-binding protein 1 (HABP1/p32/gC1qR) induces melanoma cell migration and tumor growth by NF-kappa B dependent MMP-2 activation through integrin ?(v)?(3) interaction.
Immunolocalisation studies of matrix metalloproteinases-1, -2 and -3 in human melanoma.
In melanoma, beta-catenin is a suppressor of invasion.
In vivo antitumoral effect of 4-nerolidylcatechol (4-NC) in NRAS-mutant human melanoma.
Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.
Inflammation and melanoma growth and metastasis: the role of platelet-activating factor (PAF) and its receptor.
Interdependency of cell adhesion, force generation and extracellular proteolysis in matrix remodeling.
Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice.
Intracellular processing and activation of membrane type 1 matrix metalloprotease depends on its partitioning into lipid domains.
Invasive potential of melanoma cells correlates with the expression of MT1-MMP and regulated by modulating its association with motility receptors via N-glycosylation on the receptors.
Invasiveness of cutaneous malignant melanoma is influenced by matrix metalloproteinase 1 gene polymorphism.
Involvement of tumor cell integrin alpha v beta 3 in hematogenous metastasis of human melanoma cells.
Lumican Inhibits In Vivo Melanoma Metastasis by Altering Matrix-Effectors and Invadopodia Markers.
Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity.
Lumican: a new inhibitor of matrix metalloproteinase-14 activity.
Matrix-directed regulation of pericellular proteolysis and tumor progression.
Membrane type-1 matrix metalloproteinase promotes human melanoma invasion and growth.
MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility.
MT1-MMP modulates melanoma cell dissemination and metastasis through activation of MMP2 and RAC1.
Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells.
Noncanonical Activation of Notch1 Protein by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Controls Melanoma Cell Proliferation.
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling.
Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry.
Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain.
RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis.
Role of ?-catenin signaling in the anti-invasive effect of the omega-3 fatty acid DHA in human melanoma cells.
Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes.
Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis.
Selective modulation of collagenase 1 gene expression by the chemotherapeutic agent doxorubicin.
Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities.
Targeting Extracellular Matrix Remodeling restores BRAF Inhibitor Sensitivity in BRAFi Resistant Melanoma.
The alternatively spliced RECK transcript variant 3 is a predictor of poor survival for melanoma patients being upregulated in aggressive cell lines and modulating MMP gene expression in vitro.
The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs.
The membrane tethered matrix metalloproteinase MT1-MMP at the forefront of melanoma cell invasion and metastasis.
The tetraspanin CD81 protein increases melanoma cell motility by up-regulating metalloproteinase MT1-MMP expression through the pro-oncogenic Akt-dependent Sp1 activation signaling pathways.
The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination.
Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines.
Vemurafenib resistance increases melanoma invasiveness and modulates the tumor microenvironment by MMP-2 upregulation.
[Expression of membrane-type I matrix metalloproteinase and its correlation with gelatinase A activation in cancer cell lines]
Melanoma, Experimental
Matrix metalloproteinase induction in the tumor stroma does not depend on CD147 expression in murine B16 melanoma.
Meningioma
Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas.
MERRF Syndrome
Mitochondrial DNA Mutation-Elicited Oxidative Stress, Oxidative Damage, and Altered Gene Expression in Cultured Cells of Patients with MERRF Syndrome.
Upregulation of Matrix Metalloproteinase 1 and Disruption of Mitochondrial Network in Skin Fibroblasts of Patients with MERRF Syndrome.
Mesothelioma
ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: A comparison between mesothelioma and mesothelial cells.
Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases.
MT1-MMP plays an important role in an invasive activity of malignant pleural mesothelioma cell.
Mesothelioma, Malignant
MT1-MMP plays an important role in an invasive activity of malignant pleural mesothelioma cell.
Mouth Neoplasms
Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation.
Moesin regulates the motility of oral cancer cells via MT1-MMP and E-cadherin/p120-catenin adhesion complex.
Single Nucleotide Polymorphisms and Haplotypes of MMP-14 are Associated with the Risk and Pathological Development of Oral Cancer.
Multiple Myeloma
Metalloproteinases in multiple myeloma: production of matrix metalloproteinase-9 (MMP-9), activation of proMMP-2, and induction of MMP-1 by myeloma cells.
Multiple Sclerosis
Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis.
Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Modulation of monocytes matrix metalloproteinase-2, MT1-MMP and TIMP-2 by interferon-gamma and -beta: implications to multiple sclerosis.
Muscular Dystrophies
Metalloproteinase expression is altered in cardiac and skeletal muscle in cancer cachexia.
Multifunctional roles of MT1-MMP in myofiber formation and morphostatic maintenance of skeletal muscle.
Myocardial Infarction
Cardiac restricted overexpression of membrane type-1 matrix metalloproteinase causes adverse myocardial remodeling following myocardial infarction.
Controlled Release of Matrix Metalloproteinase 1 with or wiyhout Skeletal Myoblasts Transplantion Improves Cardiac Function of Rat Hearts with Chronic Myocardial Infarction.
Direct Regulation of Membrane Type-1 Matrix Metalloproteinase Following Myocardial Infarction Causes Changes in Survival, Cardiac Function and Remodeling.
HETEROGENEITY IN MT1-MMP ACTIVITY WITH ISCHEMIA-REPERFUSION AND PREVIOUS MYOCARDIAL INFARCTION: RELATION TO REGIONAL MYOCARDIAL FUNCTION.
Matrix metalloproteinase 1 promoter polymorphisms and risk of myocardial infarction: a case-control study in a Spanish population.
Relationship of MMP-14 and TIMP-3 expression with macrophage activation and human atherosclerotic plaque vulnerability.
Myocardial Ischemia
Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy.
Myopathy, Central Core
Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice.
Myopia
Effects of lumican expression on the apoptosis of scleral fibroblasts: In vivo and in vitro experiments.
Single Nucleotide Polymorphisms in Promoter Region of Matrix Metalloproteinase 1, 2, and 3 in Japanese with High Myopia.
Myositis
Expression of specific matrix metalloproteinases in inflammatory myopathies.
Myositis, Inclusion Body
Expression of specific matrix metalloproteinases in inflammatory myopathies.
Myringosclerosis
Serum matrix metalloproteinases and tympanosclerosis.
Myxoma
Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas.
Nasopharyngeal Carcinoma
A role of MMP-14 in the regulation of invasiveness of nasopharyngeal carcinoma.
Matrix metalloproteinase 1 promotes tumorigenesis and inhibits the sensitivity to 5-fluorouracil of nasopharyngeal carcinoma.
Matrix metalloproteinase-1 (MMP-1) rs1799750 polymorphism is associated with nasopharyngeal carcinoma (NPC) risk.
Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma.
Regulation of matrix metalloproteinase-1 by Epstein-Barr virus proteins.
Necrobiosis Lipoidica
Expression of interstitial collagenase, 92-kDa gelatinase, and tissue inhibitor of metalloproteinases-1 in granuloma annulare and necrobiosis lipoidica diabeticorum.
Neoplasm Metastasis
A high throughput fluorogenic substrate for interstitial collagenase (MMP-1) and gelatinase (MMP-9).
A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases.
A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models.
Accumulation of extracellular matrix in the liver induces high metastatic potential of hepatocellular carcinoma to the lung.
Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2.
Activation of pro-MMP-2 mediated by MT1-MMP in human salivary gland carcinomas: possible regulation of pro-MMP-2 activation by TIMP-2.
Alpha V integrin prolongs collagenase production through Jun activation binding protein 1.
An association between the matrix metalloproteinase 1 promoter gene polymorphism and lymphnode metastasis in breast cancer.
Analysis of matrix metalloproteinase mRNAs expressed in hepatocellular carcinoma cell lines.
Analysis of MT1-MMP and MMP2 expression in human gastric cancers.
Association between immunohistochemical expression of matrix metalloproteinases and metastasis in oral squamous cell carcinoma: Systematic review and meta-analysis.
Association of BCSC-1 and MMP-14 with human breast cancer.
Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells.
Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Caveolin-1 inhibits membrane-type 1 matrix metalloproteinase activity.
Cell membrane-associated MT1-MMP dependent activation of MMP-2 in SiHa (human cervical cancer) cells.
CircMMP1 promotes colorectal cancer growth and metastasis by sponging miR-1238 and upregulating MMP family expression.
CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer.
Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma.
Clinical significance and prognostic value of S100A4 and matrix metalloproteinase-14 in patients with organ-confined bladder cancer.
Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma.
Clinical significance of MT1-MMP mRNA expression in breast cancer.
Clinical significance of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric cancer.
Clinicopathological and Prognostic Significance of ?5?1-integrin and MMP-14 Expressions in Colorectal Cancer.
Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from colorectal cancer.
Complete restoration of cell surface activity of transmembrane-truncated MT1-MMP by a glycosylphosphatidylinositol anchor. Implications for MT1-MMP-mediated prommp2 activation and collagenolysis in three-dimensions.
Control of MT1-MMP transport by atypical PKC during breast-cancer progression.
Conversion of stationary to invasive tumor initiating cells (TICs): role of hypoxia in membrane type 1-matrix metalloproteinase (MT1-MMP) trafficking.
Correlation of tumor- and stromal-derived MT1-MMP expression with progression of human ovarian tumors in SCID mice.
DCLK1 Plays a Metastatic-Promoting Role in Human Breast Cancer Cells.
Decreased MT1-MMP in gastric cancer suppressed cell migration and invasion via regulating MMPs and EMT.
Design and characterization of a metalloproteinase inhibitor-tethered resin for the detection of active MMPs in biological samples.
Detection and localization of mRNAs encoding matrix metalloproteinases and their tissue inhibitor in human breast pathology.
Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo.
Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (MT-MMPs) in association with MMP2 activation in injured human livers.
Differential expression of MMP and uPA systems and prognostic relevance of their expression in esophageal squamous cell carcinoma.
Differential localization of MT1-MMP in human prostate cancer tissue: Role of IGF-1R in MT1-MMP expression.
Differentiated expression of membrane type metalloproteinases (MMP-14, MMP-15) and pro-MMP2 in laryngeal squamous cell carcinoma. A novel mechanism.
Dominative role of MMP-14 over MMP-15 in human urinary bladder carcinoma on the basis of its enhanced specific activity.
Downregulation of the RECK-tumor and metastasis suppressor gene in glioma invasiveness.
Dual-functions of miR-373 and miR-520c by differently regulating the activities of MMP2 and MMP9.
E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters.
ELK3 Expression Correlates With Cell Migration, Invasion, and Membrane Type 1-Matrix Metalloproteinase Expression in MDA-MB-231 Breast Cancer Cells.
Enhanced cell surface expression of matrix metalloproteinases and their inhibitors, and tumor-induced host response in progression of human gastric carcinoma.
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis.
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas.
Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients.
Evaluation of stromal metalloproteinases and vascular endothelial growth factors in a spontaneous metastasis model.
Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression.
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas.
Expression of c-ets-1, collagenase 1, and urokinase-type plasminogen activator genes in lung carcinomas.
Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene.
Expression of extracellular matrix molecules in brain metastasis.
Expression of matrix metalloproteinases in the microenvironment of spontaneous and experimental melanoma metastases reflects the requirements for tumor formation.
Expression of membrane type 1 matrix metalloproteinase (MMP-14) in epithelial ovarian cancer: high level expression in clear cell carcinoma.
Expression of membrane type 1-matrix metalloproteinase in laryngeal carcinoma.
Expression of membrane-type matrix metalloproteinase 1 (MT1-MMP) in tumor cells enhances pulmonary metastasis in an experimental metastasis assay.
Expression of MMP-7 and MT1-MMP in peritoneal dissemination of gastric cancer.
Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in ductal carcinoma in situ and invasive ductal carcinoma of the breast.
Expression of the epidermal growth factor receptor (EGFR) and the phosphorylated EGFR in invasive breast carcinomas.
Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis.
Expression of tissue levels of matrix metalloproteinases and their inhibitors in breast cancer.
Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric adenocarcinoma.
Expressions of extracellular matrix-remodeling factors in lymph nodes from oral cancer patients.
Fusion expression of DDR2 extracellular domain in insect cells and its purification and function characterization.
Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas.
Gene expression profile analyze the molecular mechanism of CXCR7 regulating papillary thyroid carcinoma growth and metastasis.
Gold Nanoparticle-Based Fluorescent Contrast Agent with Enhanced Sensitivity.
Gonadotropin-releasing hormone-II increases membrane type I metalloproteinase production via beta-catenin signaling in ovarian cancer cells.
High expression levels of collagenase-1 and stromelysin-1 correlate with shorter disease-free survival in human metastatic melanoma.
High serum MMP-14 predicts worse survival in gastric cancer.
Identification of Wnt pathway, uPA, PAI-1, MT1-MMP, S100A4 and CXCR4 associated with enhanced metastasis of human large cell lung cancer by DNA microarray.
Immunohistochemical detection of membrane-type-1-matrix metalloproteinase in colorectal carcinoma.
Immunohistochemical expression of matrix metalloproteinases 1, 2, 9, and 14 in dermatofibrosarcoma protuberans and common fibrous histiocytoma (dermatofibroma).
Immunolocalization of matrix metalloproteinases and their inhibitors in clinical specimens of bone metastasis from breast carcinoma.
Implication of collagen type I-induced membrane-type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in the metastatic progression of breast carcinoma.
Increased Aggressiveness of Human Prostate PC-3 Tumor Cells Expressing Cell Surface Localized Membrane Type-1 Matrix Metalloproteinase (MT1-MMP).
Increased E1AF expression in mouse fibrosarcoma promotes metastasis through induction of MT1-MMP expression.
Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells.
Interaction of MT1-MMP and laminin-5gamma2 chain correlates with metastasis and invasiveness in human esophageal squamous cell carcinoma.
Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice.
Interleukin-6 increases matrix metalloproteinase-14 (MMP-14) levels via down-regulation of p53 to drive cancer progression.
Interstitial collagenase gene expression in colonic neoplasia.
Intrahepatic metastasis by orthotopic implantation of a fragment of murine hepatoma and its related molecules.
Intratumoral concentrations of tissue inhibitor of matrix metalloproteinase 1 in patients with gastric carcinoma a new biomartker for invasion and its impact on survival.
Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.
LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells.
LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration.
Loss of P53 facilitates invasion and metastasis of prostate cancer cells.
Loss of retinal cadherin facilitates mammary tumor progression and metastasis.
Matrix metalloprotease-14 is a target enzyme for detecting peritoneal metastasis in gastric cancer.
Matrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma of children and adolescents.
Matrix Metalloproteinase 1 promotes tumor formation and lung metastasis in an intratibial injection osteosarcoma mouse model.
Matrix metalloproteinase 2 promotes cell growth and invasion in colorectal cancer.
Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material.
Matrix metalloproteinase-14 expression and its prognostic value in cervical carcinoma.
Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer.
Matrix metalloproteinases may contribute compensationally to tumor invasion in T1 colorectal carcinomas.
Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma.
Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo.
Membrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: Observations from clinical and in vitro analyses.
Membrane type 1-matrix metalloproteinase promotes human prostate cancer invasion and metastasis.
Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer.
Membrane-type matrix metalloproteinases (MT-MMPs) in cell invasion.
Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression.
microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells.
Microsphere-Based Nanoindentation for the Monitoring of Cellular Cortical Stiffness Regulated by MT1-MMP.
Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers.
miR-181 suppresses metastasis via MMP-14.
miR-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Metalloproteinase-14.
miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14.
MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases.
MMP-14 can serve as a prognostic marker in patients with supraglottic cancer.
MMP1 expression is activated by Slug and enhances multi-drug resistance (MDR) in breast cancer.
Moesin regulates the motility of oral cancer cells via MT1-MMP and E-cadherin/p120-catenin adhesion complex.
Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer.
MT1-MMP and MMP-7 in invasion and metastasis of human cancers.
MT1-MMP as a PET Imaging Biomarker for Pancreas Cancer Management.
MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis.
MT1-MMP is required for efficient tumor dissemination in experimental metastatic disease.
MT1-MMP modulates melanoma cell dissemination and metastasis through activation of MMP2 and RAC1.
MT1-MMP: Endosomal delivery drives breast cancer metastasis.
Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts.
N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.
New biochemical insight of conserved water molecules at catalytic and structural Zn(2+) ions in human matrix metalloproteinase-I: a study by MD-simulation.
NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP.
O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP).
Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination.
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling.
Overexpression of MT1-MMP is insufficient to increase experimental liver metastasis of human colon cancer cells.
Overexpression of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in metastatic MDCK cells transformed by v-src.
p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression.
Pancreatic tumor cell metastasis is restricted by MT1-MMP binding protein MTCBP-1.
PLD and PA Take MT1-MMP for a Metastatic Ride.
Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP.
Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth.
Primary Ovarian Tumors With Lymphogenic and Hematogenic Metastasis Express High MMP-14, Which Colocalizes With Highly Sulfated Chondroitin Sulfate in the Stroma.
Prognostic Significance of Matrix Metalloproteinase 14 in Patients with Cancer: a Systematic Review and Meta-Analysis.
Prognostic value of membrane type 1 and 2 matrix metalloproteinase expression and gelatinase A activity in bladder cancer.
Prophylactical Low Dose Whole-Liver Irradiation Inhibited Colorectal Liver Metastasis by Regulating Hepatic Niche in Mice.
Prostate Cancer-Associated Membrane Type 1-Matrix Metalloproteinase. A Pivotal Role in Bone Response and Intraosseous Tumor Growth.
Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth.
Radiation-induced lung metastasis development is MT1-MMP-dependent in a triple-negative breast cancer mouse model.
Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method.
Re-expression of miR-200 by novel approaches regulates the expression of PTEN and MT1-MMP in pancreatic cancer.
Reduction of metastasis, cell invasion, and adhesion in mouse osteosarcoma by YM529/ONO-5920-induced blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathway.
RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis.
RNA interference screening identifies clathrin-B and cofilin-1 as mediators of MT1-MMP in endometrial cancer.
Role of RANKL-induced osteoclast formation and MMP-dependent matrix degradation in bone destruction by breast cancer metastasis.
Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis.
Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis and tumor growth in ovarian cancer.
Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis.
Serum Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) mRNA Protected by Exosomes as a Potential Biomarker for Gastric Cancer.
Shedding of RANKL by tumor-associated MT1-MMP activates Src-dependent prostate cancer cell migration.
Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer.
SLC39A6 Promotes Aggressiveness of Esophageal Carcinoma Cells by Increasing Intracellular Levels of Zinc, Activating Phosphatidylinositol 3-kinase Signaling, and Upregulating Genes That Regulate Metastasis.
Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma.
SNX27-retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis.
The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs.
The collagenase activities, interstitial collagenase and type IV collagenase, in human stomach cancer: with special reference to local spreading and lymph node metastasis.
The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression.
The influence of MMP-14, TIMP-2 and MMP-2 expression on breast cancer prognosis.
The membrane tethered matrix metalloproteinase MT1-MMP at the forefront of melanoma cell invasion and metastasis.
The polymorphism MMP1 -1607 (1G>2G) is associated with a significantly increased risk of cancers from a meta-analysis.
The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2.
The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma.
The role of MMP-14 in ovarian cancer: a systematic review.
The role of stromal cells in the expression of interstitial collagenase (matrix metalloproteinase-1) in the invasion of gastric cancer.
The tetraspanin CD81 protein increases melanoma cell motility by up-regulating metalloproteinase MT1-MMP expression through the pro-oncogenic Akt-dependent Sp1 activation signaling pathways.
The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination.
Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines.
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis.
Tumor cell-matrix interaction: pericellular matrix degradation and metastasis.
Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cells.
Two-step sandwich enzyme immunoassay using monoclonal antibodies for detection of soluble and membrane-associated human membrane type 1-matrix metalloproteinase.
Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination.
Upregulation of SPOCK2 inhibits the invasion and migration of prostate cancer cells by regulating the MT1-MMP/MMP2 pathway.
YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis.
[Correlation between MMP-2 activation and MT1-MMP mRNA expression in thymic epithelial tumors]
[Expression levels of MMP-14, ING4 and HIF-1? in 60 patients with oral squamous cell carcinoma and their clinical significance].
[Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal neoplasm]
[Implication of VEGF and MMPs in hepatic metastasis of human colon cancer]
[Interstitial collagenase and their endogenous regulators in squamous cell cervical carcinoma].
[Interstitial collagenase, gelatinases A and B and their endogenous inhibitors in squamous cell cervical carcinomas].
[MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells].
[Role of CD44 and MT1-MMP in colorectal cancer invasion and metastasis]
[Significance of membrane type-1 matrix metalloproteinase expression in breast cancer]
[The role of matrixmetalloproteinases in the tumor growth and metastasis].
Neoplasm Micrometastasis
Molecular markers of micrometastasis in oral cavity carcinomas.
Neoplasms
1-furan-2-yl-3-pyridin-2-yl-propenone inhibits the invasion and migration of HT1080 human fibrosarcoma cells through the inhibition of proMMP-2 activation and down regulation of MMP-9 and MT1-MMP.
7,8-Dihydroxyflavone attenuates TNF-?-induced skin aging in Hs68 human dermal fibroblast cells via down-regulation of the MAPKs/Akt signaling pathways.
?1 integrin-mediated signaling regulates MT1-MMP phosphorylation to promote tumor cell invasion.
A hepatic invasive human colorectal xenograft model.
A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis.
A high throughput fluorogenic substrate for interstitial collagenase (MMP-1) and gelatinase (MMP-9).
A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases.
A Multicenter Study of Early Anti-inflammatory Treatment in Patients With Acute Anterior Cruciate Ligament Tear.
A new gallium complex inhibits tumor cell invasion and matrix metalloproteinase MMP-14 expression and activity.
A new method for evaluation of urinary autocrine motility factor and tumor cell collagenase stimulating factor as markers for urinary tract cancers.
A novel host/tumor cell interaction activates matrix metalloproteinase 1 and mediates invasion through type I collagen.
A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models.
A partial catalog of proteins secreted by epidermal keratinocytes in culture.
A role for MT1-MMP as a cell death sensor/effector through the regulation of endoplasmic reticulum stress in U87 glioblastoma cells.
Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation.
ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling.
Accumulation of extracellular matrix in the liver induces high metastatic potential of hepatocellular carcinoma to the lung.
Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton.
Activatable and Cell-Penetrable Multiplex FRET Nanosensor for Profiling MT1-MMP Activity in Single Cancer Cells.
Activated EphA2 Processing by MT1-MMP Is Involved in Malignant Transformation of Ovarian Tumours In Vivo.
Activation of Epidermal Growth Factor Receptor/p38/Hypoxia-inducible Factor-1? Is Pivotal for Angiogenesis and Tumorigenesis of Malignantly Transformed Cells Induced by Hexavalent Chromium.
Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2.
Activation of fibroblast-derived matrix metalloproteinase-2 by colon-cancer cells in non-contact Co-cultures.
Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2.
Activation of matrix metalloproteinase-2 in head and neck squamous cell carcinoma: studies of clinical samples and in vitro cell lines co-cultured with fibroblasts.
Activation ratio of MMP-2 and expression of MT1-MMP are correlated in thymic epithelial tumours.
Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking.
Activity of matrix metalloproteinase-2 (MMP-2) in canine oronasal tumors.
ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis, and increased tumor growth.
Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells.
Adverse drug reaction prediction using scores produced by large-scale drug-protein target docking on high-performance computing machines.
Alpha V integrin prolongs collagenase production through Jun activation binding protein 1.
Altered transcriptional regulation of human interstitial collagenase in cultured skin fibroblasts from older donors.
An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase.
An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy.
Analysis for the major contributor of collagenase to the primary cleavage of type II collagens in cartilage degradation.
Analysis of MT1-MMP and MMP2 expression in human gastric cancers.
Anti-neovascular therapy by liposomal drug targeted to membrane type-1 matrix metalloproteinase.
Antiprotease therapy in cancer: hot or not?
Antitumor activity of a membrane lytic peptide cyclized with a linker sensitive to membrane type 1-matrix metalloproteinase.
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.
Assessing matrix metalloproteinase expression and activity in hepatocellular carcinomas.
Assignments, secondary structure and dynamics of the inhibitor-free catalytic fragment of human fibroblast collagenase.
Association between matrix metalloproteinase 1 -1607 1G>2G polymorphism and cancer risk: a meta-analysis including 19706 subjects.
Association of BCSC-1 and MMP-14 with human breast cancer.
ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion.
Atypical localization of membrane type 1-matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma.
Autocrine regulation of collagenase gene expression by TNF-alpha in U937 cells.
Balance between activation and inhibition of matrix metalloproteinase-2 (MMP-2) is altered in colorectal tumors compared to normal colonic epithelium.
Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide.
Beta-catenin activates a coordinated expression of the proinvasive factors laminin-5 gamma2 chain and MT1-MMP in colorectal carcinomas.
Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors.
Biochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cells.
Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression.
Biological significance of interstitial collagenase in DMBA-induced mammary tumors of the rat.
BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity.
c-fos-induced osteosarcoma formation in transgenic mice: cooperativity with c-jun and the role of endogenous c-fos.
Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Carcinoma of the parotid gland: developing prognostic indices.
Caveolin-1 inhibits membrane-type 1 matrix metalloproteinase activity.
CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells.
Cell membrane-associated MT1-MMP dependent activation of MMP-2 in SiHa (human cervical cancer) cells.
Cell surface activation of progelatinase A (proMMP-2) and cell migration.
Cell type specific interleukin-6 induced responses in tumor keratinocytes and stromal fibroblasts are essential for invasive growth.
Cell-cell contact activation of fibroblasts increases the expression of matrix metalloproteinases.
Cell-surface-associated tissue transglutaminase is a target of MMP-2 proteolysis.
Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system.
Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression.
Centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis.
Changes in the expression of matrix proteases and of the transcription factor c-Ets-1 during progression of precancerous bronchial lesions.
Characteristics of the alternative phenotype of microglia/macrophages and its modulation in experimental gliomas.
Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis.
Characterization of the procollagen IV cleavage products produced by a specific tumor collagenase.
Chemical Tools for Selective Activity Profiling of Endogenously Expressed MMP-14 in Multicellular Models.
Cleavage of growth differentiation factor 15 (GDF15) by membrane type 1-matrix metalloproteinase abrogates GDF15-mediated suppression of tumor cell growth.
Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar.
Cleavage of Type II and III collagens with mammalian collagenase: site of cleavage and primary structure at the NH2-terminal portion of the smaller fragment released from both collagens.
Clinical and experimental role of ring finger protein 180 on lymph node metastasis and survival in gastric cancer.
Clinical relevance of cyclooxygenase-2 and matrix metalloproteinases (MMP-2 and MT1-MMP) in human breast cancer tissue.
Clinical significance of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric cancer.
Clinicopathologic and prognostic significance of matrix metalloproteinases in rectal cancer.
Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from colorectal cancer.
Cloning and characterization of human tumor cell interstitial collagenase.
CMT-3, a non-antimicrobial tetracycline (TC), inhibits MT1-MMP activity: relevance to cancer.
Co-localisation of intra-nuclear membrane type-1 matrix metalloproteinase and hypoxia inducible factor-2? in osteosarcoma and prostate carcinoma cells.
Collagen regulation of let-7 in pancreatic cancer involves TGF-?1-mediated membrane type 1-matrix metalloproteinase expression.
Collagenase activity in epidermoid carcinoma of the oral cavity and larynx.
Collagenase activity in squamous cell carcinoma of the human parotid gland.
Collagenase induction promotes mouse tumorigenesis by two independent pathways.
Collagenase-1 injection improved tumor distribution and gene expression of cationic lipoplex.
Collagenase-1, stromelysin-1 and 92 kDa gelatinase are associated with tumor necrosis factor-alpha induced morphological change of human endothelial cells in vitro.
Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx.
Collagenase-3 induction in rat lung fibroblasts requires the combined effects of tumor necrosis factor-alpha and 12-lipoxygenase metabolites: a model of macrophage-induced, fibroblast-driven extracellular matrix remodeling during inflammatory lung injury.
Comparative analysis of matrix metalloproteinases by immunocytochemistry, immunohistochemistry and zymography in human primary brain tumours.
Comparative Analysis of Tear Proteins in Keratoconic Scleral Lens Wearers with Variation in Limbal Clearance.
Comparative expression of matrix metalloproteinases in internal malignancies and paired cutaneous metastatic lesions.
Comparative gene expression profiling of normal and degenerative discs: analysis of a rabbit annular laceration model.
Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo.
Complete restoration of cell surface activity of transmembrane-truncated MT1-MMP by a glycosylphosphatidylinositol anchor. Implications for MT1-MMP-mediated prommp2 activation and collagenolysis in three-dimensions.
Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma.
Concanavalin-A triggers inflammatory response through JAK/STAT3 signalling and modulates MT1-MMP regulation of COX-2 in mesenchymal stromal cells.
Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells.
Conjunctival expression of matrix metalloproteinase and pro-inflammatory cytokine genes following trichiasis surgery.
Construction of antisense MT1-MMP vector and its inhibitory effects on invasion of human ovarian cancer cells.
Conversion of stationary to invasive tumor initiating cells (TICs): role of hypoxia in membrane type 1-matrix metalloproteinase (MT1-MMP) trafficking.
Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14.
Coordinate action of membrane-type matrix metalloproteinase -1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion.
Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function.
Correlation of tumor- and stromal-derived MT1-MMP expression with progression of human ovarian tumors in SCID mice.
Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment.
Critical role of transient activity of MT1-MMP for ECM degradation in invadopodia.
Cyclophilin C-associated protein is a mediator for fibronectin fragment-induced matrix metalloproteinase-13 expression.
Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion.
DCLK1 Plays a Metastatic-Promoting Role in Human Breast Cancer Cells.
Decrease in LDL receptor-related protein expression and function correlates with advanced stages of Wilms tumors.
Decreased MT1-MMP in gastric cancer suppressed cell migration and invasion via regulating MMPs and EMT.
Design and characterization of a metalloproteinase inhibitor-tethered resin for the detection of active MMPs in biological samples.
Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).
Desmoplastic response in scirrhous gastric carcinoma: imbalance between collagen synthesis and degradation.
Detection and localization of mRNAs encoding matrix metalloproteinases and their tissue inhibitor in human breast pathology.
Detection of a latent soluble form of membrane type 1 matrix metalloprotease bound with tissue inhibitor of matrix metalloproteinases-2 in periprosthetic tissues and fluids from loose arthroplasty endoprostheses.
Detection of the Heterogeneous O-Glycosylation Profile of MT1-MMP Expressed in Cancer Cells by a Simple MALDI-MS Method.
Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases.
Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo.
Development of membrane type-1 matrix metalloproteinase-specific activatable fluorescent probe for malignant tumor detection.
Development of PEGylated peptide probes conjugated with (18)F-labeled BODIPY for PET/optical imaging of MT1-MMP activity.
Differential effect of the expression of TGF-? pathway inhibitors, Smad-7 and Ski, on invasive breast carcinomas: relation to biologic behavior.
Differential expression and activity status of MMP-1, MMP-2 and MMP-9 in tumor and stromal cells of squamous cell carcinomas of the lung.
Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (MT-MMPs) in association with MMP2 activation in injured human livers.
Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis.
Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers.
Differential regulation of interstitial collagenase (MMP-1) gene expression by ETS transcription factors.
Differential regulation of matrix metalloproteinases in human cancer cells by exogenous factors.
Differential regulation of MMP-9 and TIMP-2 expression in malignant melanoma developed in metallothionein/RET transgenic mice.
Differential stromal regulation of MMP-1 expression in benign and malignant keratinocytes.
Differentiated expression of membrane type metalloproteinases (MMP-14, MMP-15) and pro-MMP2 in laryngeal squamous cell carcinoma. A novel mechanism.
Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours.
Direct production of functional matrix metalloproteinase--14 without refolding or activation and its application for in vitro inhibition assays.
Directed Evolution of Protease Beacons that Enable Sensitive Detection of Endogenous MT1-MMP Activity in Tumor Cell Lines.
Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck.
Dominative role of MMP-14 over MMP-15 in human urinary bladder carcinoma on the basis of its enhanced specific activity.
Down-Regulation of MT1-MMP expression by the alpha3 chain of type IV collagen inhibits bronchial tumor cell line invasion.
Down-regulation of MT1-MMP expression suppresses tumor cell invasion in metastatic human SW626 ovarian cancer cells.
Downregulation of reversion-inducing cysteine-rich protein with Kazal motifs in malignant melanoma: inverse correlation with membrane-type 1-matrix metalloproteinase and tissue inhibitor of metalloproteinase 2.
Downregulation of SFRP5 expression and its inverse correlation with those of MMP-7 and MT1-MMP in gastric cancer.
Downregulation of the RECK-tumor and metastasis suppressor gene in glioma invasiveness.
Dual functions of ARP101 in targeting membrane type-1 matrix metalloproteinase: Impact on U87 glioblastoma cell invasion and autophagy signaling.
Dual-functions of miR-373 and miR-520c by differently regulating the activities of MMP2 and MMP9.
Early combined treatment with carboplatin and the MMP inhibitor, prinomastat, prolongs survival and reduces systemic metastasis in an aggressive orthotopic lung cancer model.
Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis.
Effect of hGC-MSCs from human gastric cancer tissue on cell proliferation, invasion and epithelial-mesenchymal transition in tumor tissue of gastric cancer tumor-bearing mice.
Effect of the different phosphorylated Smad2 protein localizations on the invasive breast carcinoma phenotype.
Effects of flexibility of the ?2 chain of type I collagen on collagenase cleavage.
Effects of miR-7 on Hcy-induced rat cerebral arterial vascular smooth muscle cell proliferation, migration and inflammatory factor expression by targeting MMP-14 to regulate TLR4/NF-?B signaling pathway.
Effects of tumor necrosis factor-alpha and interferon-gamma on expressions of matrix metalloproteinase-2 and -9 in human bladder cancer cells.
Elastin peptides activate extracellular signal-regulated kinase 1/2 via a Ras-independent mechanism requiring both p110gamma/Raf-1 and protein kinase A/B-Raf signaling in human skin fibroblasts.
Elastokine-mediated up-regulation of MT1-MMP is triggered by nitric oxide in endothelial cells.
Elevated expression of membrane type 1 metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system.
Elevated expression of membrane-type 1 and 3 matrix metalloproteinases in rat vascular smooth muscle cells activated by arterial injury.
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines.
ELK3 Expression Correlates With Cell Migration, Invasion, and Membrane Type 1-Matrix Metalloproteinase Expression in MDA-MB-231 Breast Cancer Cells.
Emerging concepts in the regulation of membrane-type 1 matrix metalloproteinase activity.
EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface.
EMMPRIN expression in oral SCC is regulated by FYN kinase.
EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma.
Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.
Enhanced cell surface expression of matrix metalloproteinases and their inhibitors, and tumor-induced host response in progression of human gastric carcinoma.
Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration.
Enhancement of fibroblast collagenase-1 (MMP-1) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases Jun N-terminal kinase and p38.
Enhancement of membrane-type 1-matrix metalloproteinase (MT1-MMP) production and sequential activation of progelatinase A on human squamous carcinoma cells co-cultured with human dermal fibroblasts.
EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.
EphA2 overexpression is associated with angiogenesis in ovarian cancer.
Epigallocatechin gallate targeting of membrane type 1 matrix metalloproteinase-mediated Src and Janus kinase/signal transducers and activators of transcription 3 signaling inhibits transcription of colony-stimulating factors 2 and 3 in mesenchymal stromal cells.
Epigenetic Control of the Invasion-promoting MT1-MMP/MMP-2/TIMP-2 Axis in Cancer Cells.
Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients.
Equine sarcoid fibroblasts over-express matrix metalloproteinases and are invasive.
Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies.
Evaluation of CD44 and TGF-B Expression in Oral Carcinogenesis.
Evaluation of stromal metalloproteinases and vascular endothelial growth factors in a spontaneous metastasis model.
Evidence of MTCBP-1 interaction with the cytoplasmic domain of MT1-MMP: Implications in the autophagy cell index of high-grade glioblastoma.
Examination of recombinant truncated mature human fibroblast collagenase by mass spectrometry: identification of differences with the published sequence and determination of stable isotope incorporation.
Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression.
Expression and localization of membrane-type-1 matrix metalloproteinase, CD 44, and laminin-5gamma2 chain during colorectal carcinoma tumor progression.
Expression and tissue localization of membrane-type 1, 2, and 3 matrix metalloproteinases in human astrocytic tumors.
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas.
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human urothelial carcinomas.
Expression of c-ets-1, collagenase 1, and urokinase-type plasminogen activator genes in lung carcinomas.
Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer.
Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas.
Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene.
Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cells.
Expression of extracellular matrix molecules in brain metastasis.
Expression of integrin alpha(v)beta(3) correlates with activation of membrane-type matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) in human melanoma cells in vitro and in vivo.
Expression of matrix metalloprotease-2 (MMP-2) and the activator membrane type 1 (MT1-MMP) in canine mammary carcinomas.
Expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-13, and MT1-MMP in skin tumors of human papillomavirus type 8 transgenic mice.
Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine.
Expression of matrix metalloproteinase-2 and -9 and membrane-type 1 matrix metalloproteinase in melanocytic tumors of dogs and canine melanoma cell lines.
Expression of matrix metalloproteinase-2 in serous borderline ovarian tumors is associated with noninvasive implant formation.
Expression of matrix metalloproteinases (MMP-2, MMP-9, MT1-MMP) and their inhibitors (TIMP-1, TIMP-2) in common epithelial tumors of the ovary.
Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: quantificative and morphological analyses.
Expression of matrix metalloproteinases and their specific inhibitors in normal and different human thyroid tumor cell lines.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in reactive and neoplastic lymphoid cells.
Expression of matrix metalloproteinases in gallbladder carcinoma and their significance in carcinogenesis.
Expression of matrix metalloproteinases in the microenvironment of spontaneous and experimental melanoma metastases reflects the requirements for tumor formation.
Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization.
Expression of membrane type 1 matrix metalloproteinase in medullary thyroid carcinoma: Prognostic implications.
Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion.
Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma.
Expression of membrane type 1-matrix metalloproteinase in laryngeal carcinoma.
Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells.
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) mRNA in trophoblast and endometrial epithelial cell populations of the synepitheliochorial placenta of goats (Capra hircus).
Expression of membrane-type 1 matrix metalloproteinase and activation of progelatinase A in human osteoarthritic cartilage.
Expression of membrane-type 1, 2, and 3 matrix metalloproteinases messenger RNA in ovarian carcinoma cells in serous effusions.
Expression of membrane-type matrix metalloproteinase 1 (MT1-MMP) in tumor cells enhances pulmonary metastasis in an experimental metastasis assay.
Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas.
Expression of messenger RNAs for membrane-type 1, 2, and 3 matrix metalloproteinases in human renal cell carcinomas.
Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events.
Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas.
Expression of metastasis-associated mts1 gene is co-induced with membrane type-1 matrix metalloproteinase (MT1-MMP) during oncogenic transformation and tubular formation of Madin Darby canine kidney (MDCK) epithelial cells.
Expression of MMP-2 and MMP-9, their inhibitors, and the activator MT1-MMP in primary breast carcinomas.
Expression of MMP-7 and MT1-MMP in oral squamous cell carcinoma as predictive indicator for tumor invasion and prognosis.
Expression of MMP-7 and MT1-MMP in peritoneal dissemination of gastric cancer.
Expression of MMPs and TIMPs in human pterygia and cultured pterygium epithelial cells.
Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.
Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in ductal carcinoma in situ and invasive ductal carcinoma of the breast.
Expression of proteolytic enzymes in head and neck cancer-associated fibroblasts.
Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis.
Expression of the transcription factor c-Ets1 correlates with the occurrence of invasive processes during normal and pathological development.
Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma.
Expression of tissue levels of matrix metalloproteinases and their inhibitors in breast cancer.
Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric adenocarcinoma.
Expression of urokinase plasminogen activator and its receptor in advanced epithelial ovarian cancer patients.
Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland.
Expressions of extracellular matrix-remodeling factors in lymph nodes from oral cancer patients.
Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis.
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex.
Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.
Fibroblast growth factor-1 transcriptionally induces membrane type-1 matrix metalloproteinase expression in prostate carcinoma cell line.
Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo.
Fli-1 Activation through Targeted Promoter Activity Regulation Using a Novel 3', 5'-diprenylated Chalcone Inhibits Growth and Metastasis of Prostate Cancer Cells.
Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo.
Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase.
Functional relationship between matrix metalloproteinase-11 and matrix metalloproteinase-14.
Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP.
Fusion expression of DDR2 extracellular domain in insect cells and its purification and function characterization.
Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas.
Gelatinase A, membrane type 1 matrix metalloproteinase, and extracellular matrix metalloproteinase inducer mRNA expression: correlation with invasive growth of breast cancer.
Gene expression of interstitial collagenase (matrix metalloproteinase 1) in gastrointestinal tract cancers.
Gene expression profile analyze the molecular mechanism of CXCR7 regulating papillary thyroid carcinoma growth and metastasis.
Genetically Encoded Fluorescent Biosensors for Live-Cell Imaging of MT1-MMP Protease Activity.
Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion.
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase.
Gold Nanoparticle-Based Fluorescent Contrast Agent with Enhanced Sensitivity.
Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype.
Heat shock suppresses membrane type 1-matrix metalloproteinase production and progelatinase A activation in human fibrosarcoma HT-1080 cells and thereby inhibits cellular invasion.
Heat shock-mediated transient increase in intracellular 3',5'-cyclic AMP results in tumor specific suppression of membrane type 1-matrix metalloproteinase production and progelatinase A activation.
Heparin and heparan sulfate binding sites on B-16 melanoma cells.
Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases.
Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14.
High levels of MMP-2, MMP-9, MT1-MMP and TIMP-2 mRNA correlate with poor survival in ovarian carcinoma.
High MMP-1 mRNA expression is a risk factor for disease-free and overall survivals in patients with invasive breast carcinoma.
High serum MMP-14 predicts worse survival in gastric cancer.
High throughput analysis of proteins associating with a proinvasive MT1-MMP in human malignant melanoma A375 cells.
High-affinity peptide against MT1-MMP for in vivo tumor imaging.
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.
Human breast cancer cells activate procollagenase-1 and invade type I collagen: invasion is inhibited by all-trans retinoic acid.
Human hemokinin-1 promotes migration of melanoma cells and increases MMP-2 and MT1-MMP expression by activating tumor cell NK1 receptors.
Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer.
Human liver fibroblast capacity for synthesizing interstitial collagenase in vitro.
Human Plasma Levels of Vascular Endothelial Growth Factor, Matrix Metalloproteinase 9, and Tissue Inhibitor of Matrix Metalloproteinase 1 and Their Applicability as Tumor Markers in Diagnoses of Cervical Cancer Based on ROC Analysis.
Hyaluronan-binding protein 1 (HABP1/p32/gC1qR) induces melanoma cell migration and tumor growth by NF-kappa B dependent MMP-2 activation through integrin ?(v)?(3) interaction.
Hybrid graphene/Au activatable theranostic agent for multimodalities imaging guided enhanced photothermal therapy.
Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP.
Identification of activated matrix metalloproteinase-2 (MMP-2) as the main gelatinolytic enzyme in malignant melanoma by in situ zymography.
Identification of cis-acting promoter elements that support expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) in v-src transformed Madin-Darby canine kidney cells.
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma.
Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression.
Identification of Proteolytic Cleavage Sites of EphA2 by Membrane Type 1 Matrix Metalloproteinase on the Surface of Cancer Cells.
Identification of substrate sequences for membrane type-1 matrix metalloproteinase using bacteriophage peptide display library.
Imatinib-associated matrix metalloproteinase suppression in p16-positive squamous cell carcinoma compared to HPV-negative HNSCC cells in vitro.
Immunohistochemical demonstration of EphA2 processing by MT1-MMP in invasive cutaneous squamous cell carcinoma.
Immunohistochemical detection of membrane-type-1-matrix metalloproteinase in colorectal carcinoma.
Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors.
Immunohistochemical expression of matrix metalloproteinases 1, 2, 9, and 14 in dermatofibrosarcoma protuberans and common fibrous histiocytoma (dermatofibroma).
Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts.
Impaired tyrosine phosphorylation of membrane type 1-matrix metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates tumor growth in mice.
In vitro irradiation of basement membrane enhances the invasiveness of breast cancer cells.
In vivo imaging of membrane type-1 matrix metalloproteinase with a novel activatable near-infrared fluorescence probe.
In vivo optical imaging of membrane-type matrix metalloproteinase (MT-MMP) activity.
In vivo sensing of proteolytic activity with an NSET-based NIR fluorogenic nanosensor.
Increased Aggressiveness of Human Prostate PC-3 Tumor Cells Expressing Cell Surface Localized Membrane Type-1 Matrix Metalloproteinase (MT1-MMP).
Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas.
Increased expression of collagenase-3 (MMP-13) and MT1-MMP in oesophageal cancer is related to cancer aggressiveness.
Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase.
Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas.
Increased expression of membrane type 1-matrix metalloproteinase in head and neck carcinoma.
Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma.
Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas.
Increased immunoreactivity of MT1-MMP and beta-catenin in high risk basal cell carcinoma.
Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.
Increases of stromelysin messenger-RNA expression in ras-transformed ref cells in-vivo.
Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1.
Induction of macrophage matrix metalloproteinase biosynthesis by surfactant protein D.
Induction of membrane-type matrix metalloproteinase 1 (MT1-MMP) expression in human fibroblasts by breast adenocarcinoma cells.
Induction of Smad1 by MT1-MMP contributes to tumor growth.
Inflammatory cytokines and oxidized low density lipoproteins increase endothelial cell expression of membrane type 1-matrix metalloproteinase.
Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.
Inhibition of matrix metalloproteinase-14 (MMP-14)-mediated cancer cell migration.
Inhibition of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation blocks tumor progression in mice.
Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain.
Inhibition of tumor invasion of smooth muscle cell layers by recombinant human metalloproteinase inhibitor.
Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas.
Insufficient CD100 shedding contributes to suppression of CD8+ T cell activity in non-small cell lung cancer.
Integrated functions of membrane-type 1 matrix metalloproteinase in regulating cancer malignancy: Beyond a proteinase.
Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes.
Interaction of MT1-MMP and laminin-5gamma2 chain correlates with metastasis and invasiveness in human esophageal squamous cell carcinoma.
Interaction of Munc18c and Syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumour cells.
Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice.
Interleukin-1 beta- and tumor necrosis factor-alpha-independent monocyte stimulation of fibroblast collagenase activity.
Interleukin-6 increases matrix metalloproteinase-14 (MMP-14) levels via down-regulation of p53 to drive cancer progression.
Interplay of transcription factors STAT3, STAT1 and AP-1 mediates activity of the matrix metallo-proteinase-1 promoter in colorectal carcinoma cells.
Interstitial collagenase and the ED-B oncofetal domain of fibronectin are markers of angiogenesis in human skin tumors.
Interstitial collagenase gene expression in colonic neoplasia.
Interstitial collagenases as markers of tumor progression.
Intradomain cleavage of the inhibitory prodomain is essential to the pro-tumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP) in vivo.
Intrahepatic metastasis by orthotopic implantation of a fragment of murine hepatoma and its related molecules.
Intratumoral concentrations of tissue inhibitor of matrix metalloproteinase 1 in patients with gastric carcinoma a new biomartker for invasion and its impact on survival.
Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis.
Invasion by activated macrophages requires delivery of nascent membrane-type-1 matrix metalloproteinase through late endosomes/lysosomes to the cell surface.
Invasion of connective tissue by human carcinoma cell lines: requirement for urokinase, urokinase receptor, and interstitial collagenase.
Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complex.
Invasiveness of hepatocellular carcinoma cell lines: contribution of membrane-type 1 matrix metalloproteinase.
Involvement of lipid peroxidation and organic peroxides in UVA-induced matrix metalloproteinase-1 expression.
Isolation and characterization of human monoclonal antibodies specific to MMP-1A, MMP-2 and MMP-3.
Isolation and characterization of novel RECK tumor suppressor gene splice variants.
iTRAQ-Based Membrane Proteomics Reveals Plasma Membrane Proteins Change During HepaRG Cell Differentiation.
Key proteins of invadopodia are overexpressed in oral squamous cell carcinoma suggesting an important role of MT1-MMP in the tumoral progression.
Lack of Association between Membrane-Type 1 Matrix Metalloproteinase Expression and Clinically Relevant Molecular or Morphologic Tumor Characteristics at the Leading Edge of Invasive Colorectal Carcinoma.
Less is more: low expression of MT1-MMP is optimal to promote migration and tumourigenesis of breast cancer cells.
Letter regarding "MT1-MMP is not a good prognosticator of cancer survival: evidence from 11 studies" by Wu KP et al.
LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells.
LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration.
Local activity of matrix metalloproteinases in a case of botryoid sarcoma.
Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains.
Localization of mRNAs representing collagenase and TIMP in sections of healing human burn wounds.
Localized surface plasmon resonance based nanobiosensor for biomarker detection of invasive cancer cells.
Low collagenase-1 (MMP-1) and MT1-MMP expression levels are favourable survival markers in advanced colorectal carcinoma.
Low expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) indicates a shorter survival after resection in patients with adenocarcinoma of the lung.
Lumican: a new inhibitor of matrix metalloproteinase-14 activity.
Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP.
Marshall Urist Award. Interstitial collagenase gene expression correlates with in vitro invasion in human chondrosarcoma.
Mathematical modeling of cancer invasion: the role of membrane-bound matrix metalloproteinases.
Matrix influence on the tumor cell stimulation of fibroblast collagenase production.
Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia.
Matrix metalloproteinase 1 and circulating tumor cells in early breast cancer.
Matrix Metalloproteinase 1 promotes tumor formation and lung metastasis in an intratibial injection osteosarcoma mouse model.
Matrix metalloproteinase 2 promotes cell growth and invasion in colorectal cancer.
Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database.
Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities.
Matrix metalloproteinase induction in the tumor stroma does not depend on CD147 expression in murine B16 melanoma.
Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material.
Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses.
Matrix metalloproteinase production by cultured human endometrial stromal cells: identification of interstitial collagenase, gelatinase-A, gelatinase-B, and stromelysin-1 and their differential regulation by interleukin-1 alpha and tumor necrosis factor-alpha.
Matrix metalloproteinase-1 promoter polymorphism and lung cancer risk.
Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation.
Matrix Metalloproteinase-14 (MT1-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis.
Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer.
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas.
Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression.
Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis.
Matrix metalloproteinases may contribute compensationally to tumor invasion in T1 colorectal carcinomas.
Matrix metalloproteinases play an active role in Wnt1-induced mammary tumorigenesis.
Matrix metalloproteinases, T cell homing and beta-cell mass in type 1 diabetes.
Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion.
Matrix-directed regulation of pericellular proteolysis and tumor progression.
Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques.
Matrix-metalloproteinases in bronchopulmonary carcinomas.
mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization.
Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma.
Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes.
Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration.
Membrane type 1 matrix metalloproteinase detection in tumors, using the iodinated endogenous [123I]-tissue inhibitor 2 of metalloproteinases as imaging agent.
Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules.
Membrane type 1 matrix metalloproteinase expression in human atherosclerotic plaques: evidence for activation by proinflammatory mediators.
Membrane type 1 matrix metalloproteinase induces epithelial-to-mesenchymal transition in prostate cancer.
Membrane type 1 matrix metalloproteinase regulates anaplastic thyroid carcinoma cell growth and invasion into the collagen matrix.
Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia.
Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation.
Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor.
Membrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: Observations from clinical and in vitro analyses.
Membrane type 1-matrix metalloproteinase promotes human prostate cancer invasion and metastasis.
Membrane type 1-matrix metalloproteinase/Akt signaling axis modulates TNF-?-induced procoagulant activity and apoptosis in endothelial cells.
Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix.
Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface.
Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: correlation of MMP-14 mRNA expression and proteolytic activity.
Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability.
Membrane type-1 matrix metalloproteinase confers aneuploidy and tumorigenicity on mammary epithelial cells.
Membrane Type-1 Matrix Metalloproteinase Expression in Acute Myeloid Leukemia and Its Upregulation by Tumor Necrosis Factor-?.
Membrane type-1 matrix metalloproteinase functions as a proprotein self-convertase. Expression of the latent zymogen in Pichia pastoris, autolytic activation, and the peptide sequence of the cleavage forms.
Membrane type-1 matrix metalloproteinase promotes human melanoma invasion and growth.
Membrane type-1 matrix metalloproteinase stimulates tumour cell-induced platelet aggregation: role of receptor glycoproteins.
Membrane-bound MMP-14 protease-activatable adeno-associated viral vectors for gene delivery to pancreatic tumors.
Membrane-type 1 matrix metalloproteinase (MT1-MMP) ubiquitination at K581 increases cellular invasion through type-I collagen.
Membrane-type 1 matrix metalloproteinase and cell migration.
Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors.
Membrane-Type 1 Matrix Metalloproteinase Downregulates Fibroblast Growth Factor-2 Binding to the Cell Surface and Intracellular Signaling.
Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer.
Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells.
Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion.
Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases.
Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium.
Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin gamma 2 chain.
Membrane-type matrix metalloproteinase-1 (MT1-MMP) is down-regulated in estrogen-deficient rat osteoblast in vivo.
Membrane-type matrix metalloproteinase-1(MT1-MTP) gene is overexpressed in highly invasive hepatocellular carcinomas.
Membrane-type matrix metalloproteinases (MT-MMPs) in cell invasion.
Membrane-type metalloproteinases in tumor invasion.
Membrane-type-1 matrix metalloproteinase confers tumorigenicity on nonmalignant epithelial cells.
Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion.
Metaanalysis of the significance of matrix metalloproteinases for lymph node disease in patients with head and neck squamous cell carcinoma.
Metalloproteinase binding proteins: WO2009097397.
Metalloproteinases in juvenile angiofibroma--a collagen rich tumor.
Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance.
Methylseleninic acid inhibits PMA-stimulated pro-MMP-2 activation mediated by MT1-MMP expression and further tumor invasion through suppression of NF-kappaB activation.
MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10.
microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells.
Microsphere-Based Nanoindentation for the Monitoring of Cellular Cortical Stiffness Regulated by MT1-MMP.
Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers.
Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression.
Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin ?5?1 and tumour growth.
miR-150-5p and miR-133a suppress glioma cell proliferation and migration through targeting membrane-type-1 matrix metalloproteinase.
miR-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Metalloproteinase-14.
miR?146a?5p targets TCSF and influences cell growth and apoptosis to repress NSCLC progression.
miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14.
miRNA-584-5p exerts tumor suppressive functions in human neuroblastoma through repressing transcription of matrix metalloproteinase 14.
MMP inhibition blocks fibroblast-dependent skin cancer invasion, reduces vascularization and alters VEGF-A and PDGF-BB expression.
MMP-14 (MT1-MMP) Is a Biomarker of Surgical Outcome and a Potential Mediator of Hearing Loss in Patients With Vestibular Schwannomas.
MMP-14 and CD44 in Epithelial-to-Mesenchymal Transition (EMT) in ovarian cancer.
MMP-14 can serve as a prognostic marker in patients with supraglottic cancer.
MMP-14 Triggered Fluorescence Contrast Agent.
MMP-2 and TIMP-2 expression correlates with poor prognosis in cervical carcinoma--a clinicopathologic study using immunohistochemistry and mRNA in situ hybridization.
MMP-2-responsive fluorescent nanoprobes for enhanced selectivity of tumor cell uptake and imaging.
Mmp1a and Mmp1b are not functional orthologs to human MMP1 in cigarette smoke induced lung disease.
Modulation of peritumoral fibroblasts with a membrane-tethered tissue inhibitor of metalloproteinase (TIMP) for the elimination of cancer cells.
Modulation of the membrane type 1 matrix metalloproteinase cytoplasmic tail enhances tumor cell invasion and proliferation in three-dimensional collagen matrices.
Molecular markers of micrometastasis in oral cavity carcinomas.
Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer.
Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression.
Monoclonal antibody preparation and purification of a tumor cell collagenase-stimulatory factor.
Morbillivirus infection of the mouse central nervous system induces region-specific upregulation of MMPs and TIMPs correlated to inflammatory cytokine expression.
mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas.
mRNA levels of membrane-type 1 matrix metalloproteinase (MT1-MMP), MMP-2, and MMP-9 and of their inhibitors TIMP-2 and TIMP-3 in normal thyrocytes and thyroid carcinoma cell lines.
MT-MMPS as Regulators of Vessel Stability Associated with Angiogenesis.
MT1-MMP activatable fluorogenic probes with enhanced specificity via high-affinity peptide conjugation for tumor imaging.
MT1-MMP Activation of TGF-? Signaling Enables Intercellular Activation of an Epithelial-mesenchymal Transition Program in Cancer.
MT1-MMP and integrins: Hand-to-hand in cell communication.
MT1-MMP and MMP-2 mRNA expression in human ovarian tumors: possible implications for the role of desmoplastic fibroblasts.
MT1-MMP and MMP-7 in invasion and metastasis of human cancers.
MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.
MT1-MMP as a PET Imaging Biomarker for Pancreas Cancer Management.
MT1-MMP correlates with MMP-2 activation potential seen after epithelial to mesenchymal transition in human breast carcinoma cells.
MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility.
MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion.
MT1-MMP expression in first-trimester placental tissue is upregulated in type 1 diabetes as a result of elevated insulin and tumor necrosis factor-alpha levels.
MT1-MMP expression level status dictates the in vitro action of lupeol on inflammatory biomarkers MMP-9 and COX-2 in medulloblastoma cells.
MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression.
MT1-MMP is not a good prognosticator of cancer survival: evidence from 11 studies.
MT1-MMP is required for efficient tumor dissemination in experimental metastatic disease.
MT1-MMP modulates melanoma cell dissemination and metastasis through activation of MMP2 and RAC1.
MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway.
MT1-MMP promotes cell growth and ERK activation through c-Src and paxillin in three-dimensional collagen matrix.
MT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis.
MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins.
MT1-MMP-Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy.
MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7.
MT1-mmp: a collagenase essential for tumor cell invasive growth.
MT1-MMP: a potent modifier of pericellular microenvironment.
MT1-MMP: Endosomal delivery drives breast cancer metastasis.
MT1-MMP: universal or particular player in angiogenesis?
mTOR Repression in Response to Amino Acid Starvation Promotes ECM Degradation Through MT1-MMP Endocytosis Arrest.
N-Acetylglucosaminyltransferase V triggers overexpression of MT1-MMP and reinforces the invasive/metastatic potential of cancer cells.
N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.
N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods.
Necrosis induction in glioblastoma cells reveals a new "bioswitch" function for the MT1-MMP/G6PT signaling axis in proMMP-2 activation versus cell death decision.
New pathway links from cancer-progression determinants to gene expression of matrix metalloproteinases in breast cancer cells.
New photodynamic molecular beacons (PMB) as potential cancer-targeted agents in PDT.
NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-?B pathway.
Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells.
Non-proteolytic, receptor/ligand interactions associate cellular membrane type-1 matrix metalloproteinase with the complement component C1q.
Noncanonical Activation of Notch1 Protein by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Controls Melanoma Cell Proliferation.
Noninvasive Bioluminescence Imaging of Matrix Metalloproteinase-14 Activity in Lung Cancer Using a Membrane-Bound Biosensor.
Novel MT1-MMP small molecule inhibitors based on insights into hemopexin domain function in tumor growth.
Nucleus-Invadopodia Duo During Cancer Invasion.
O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP).
Osteopontin alters endothelial and valvular interstitial cell behaviour in calcific aortic valve stenosis through HMGB1 regulation.
Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells.
Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination.
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling.
Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice.
Overexpression of MT3-MMP in hepatocellular carcinoma correlates with capsular invasion.
OXIDATIVE STRESS AND PROSTATE CANCER PROGRESSION ARE ELICITED BY MEMBRANE-TYPE 1 MATRIX METALLOPROTEINASE (MT1-MMP).
p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression.
p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer.
Pancreatic Cancer Cells Respond to Type I Collagen by Inducing Snail Expression to Promote Membrane Type 1 Matrix Metalloproteinase-dependent Collagen Invasion.
Pancreatic tumor cell metastasis is restricted by MT1-MMP binding protein MTCBP-1.
PEA3 is necessary for optimal epidermal growth factor receptor-stimulated matrix metalloproteinase expression and invasion of ovarian tumor cells.
Phagocytosis of collagen by fibroblasts and invasive cancer cells is mediated by MT1-MMP.
Pharmacology of [3H]-pyrilamine binding and of the histamine-induced inositol phosphates generation, intracellular Ca2+ -mobilization and cytokine release from human corneal epithelial cells.
Phase Differential Enhancement of FLIM to Distinguish FRET Components of a Biosensor for Monitoring Molecular Activity of Membrane Type 1 Matrix Metalloproteinase in Live Cells.
Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry.
Phosphoramidate-based peptidomimetic inhibitors of membrane type-1 matrix metalloproteinase.
PLAU1 Facilitated Proliferation, Invasion, and Metastasis via Interaction With MMP1 in Head and Neck Squamous Carcinoma.
Podoplanin promotes the invasion of oral squamous cell carcinoma in coordination with MT1-MMP and Rho GTPases.
Polarized MT1-MMP-CD44 interaction and CD44 cleavage during cell retraction reveal an essential role for MT1-MMP in CD44-mediated invasion.
Polyethylenimine-coated SPION exhibits potential intrinsic anti-metastatic properties inhibiting migration and invasion of pancreatic tumor cells.
Polymorphisms in MMP-14 and MMP-2 genes and ovarian cancer survival.
Polymorphonuclear cells stimulate the migration and metastatic potential of rat sarcoma cells.
Positive correlation between inhibitors of matrix metalloproteinase 1 and matrix metalloproteinases in malignant ovarian tumor tissues.
Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas.
Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP.
Potential for the 2G single nucleotide polymorphism in the promoter of matrix metalloproteinase to enhance gene expression in normal stromal cells.
Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth.
Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.
Presence of active gelatinases in endometrial carcinoma and correlation of matrix metalloproteinase expression with increasing tumor grade and invasion.
Presence of high levels of MT1-MMP protein in fibroblastic cells of human invasive carcinomas.
Primary breast myoepithelial cells exert an invasion-suppressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fibroblasts and tumour cells.
Primary Ovarian Tumors With Lymphogenic and Hematogenic Metastasis Express High MMP-14, Which Colocalizes With Highly Sulfated Chondroitin Sulfate in the Stroma.
Primary renal neuroblastoma with metastasis and matrix metalloproteinase-14 expression.
Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase.
Profiling of differential gene expression in Wilms tumor by cDNA expression array.
Progesterone and calcitriol reduce invasive potential of endometrial cancer cells by targeting ARF6, NEDD9 and MT1-MMP.
Prognostic Influence of Tumor Stroma on Breast Cancer Subtypes.
Prognostic Significance of Matrix Metalloproteinase 14 in Patients with Cancer: a Systematic Review and Meta-Analysis.
Prognostic significance of matrix metalloproteinases type I expression and tumor front parameters in the presence of lymph node micrometastases in carcinoma of the larynx.
Prognostic value of membrane type 1 and 2 matrix metalloproteinase expression and gelatinase A activity in bladder cancer.
Prognostic values of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression in bladder cancer.
Prostate Cancer-Associated Membrane Type 1-Matrix Metalloproteinase. A Pivotal Role in Bone Response and Intraosseous Tumor Growth.
Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth.
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited.
Protective effect of MAAs extracted from Porphyra tenera against UV irradiation-induced photoaging in mouse skin.
Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein.
Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.
Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells.
Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy.
Proteolyzed matrix as a template for the regulation of tumor progression.
Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion.
Purification of a gelatin-degrading type IV collagenase secreted by ras oncogene-transformed fibroblasts.
Quantitative cell dispersion analysis: new test to measure tumor cell aggressiveness.
Quantitative FRET Imaging to Visualize the Invasiveness of Live Breast Cancer Cells.
Rac1 mediates type I collagen-dependent MMP-2 activation. role in cell invasion across collagen barrier.
Radiation-induced lung metastasis development is MT1-MMP-dependent in a triple-negative breast cancer mouse model.
Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method.
Radioiodinated Peptidic Imaging Probes for in Vivo Detection of Membrane Type-1 Matrix Metalloproteinase in Cancers.
Rat carcinoma cells in long-term, serum-free culture provide a continuing supply of collagenase.
Re-expression of miR-200 by novel approaches regulates the expression of PTEN and MT1-MMP in pancreatic cancer.
Red-shifted fluorescent proteins monitor enzymatic activity in live HT-1080 cells with fluorescence lifetime imaging microscopy (FLIM).
Reduced expression of insulin-like growth factor-binding protein-3 (IGFBP-3) in Squamous cell carcinoma complicating recessive dystrophic epidermolysis bullosa.
Regulation of gelatinases in human airway smooth muscle cells: mechanism of progelatinase A activation.
Regulation of membrane-type 1 matrix metalloproteinase activity by vacuolar H+-ATPases.
Regulation of MT1-MMP activity by ?-catenin in MDCK non-cancer and HT1080 cancer cells.
Regulation of MT1-MMP Activity through Its Association with ERMs.
Regulation of MT1-MMP and MMP-2 by the serpin PEDF: a promising new target for metastatic cancer.
Relation of MT1-MMP gene expression to outcomes in colorectal cancer.
Restricted expression of membrane type 1-matrix metalloproteinase by myofibroblasts adjacent to human breast cancer cells.
RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis.
RNA interference screening identifies clathrin-B and cofilin-1 as mediators of MT1-MMP in endometrial cancer.
Role of MT-MMPs and MMP-2 in pancreatic cancer progression.
Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive tumors transplanted in mice with severe combined immunodeficiency.
Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cells.
Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma.
Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis.
Roles of pericellular proteolysis by membrane type-1 matrix metalloproteinase in cancer invasion and angiogenesis.
SCCRO (DCUN1D1) induces extracellular matrix invasion by activating matrix metalloproteinase 2.
Screening, Identification, and Characterization of an Affinity Peptide Specific to MT1-MMP and Its Application in Tumor Imaging.
SCUBE3 regulation of early lung cancer angiogenesis and metastatic progression.
Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes.
Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis and tumor growth in ovarian cancer.
Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis.
Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.
Selective modulation of collagenase 1 gene expression by the chemotherapeutic agent doxorubicin.
Sequence-specific silencing of MT1-MMP expression suppresses tumor cell migration and invasion: importance of MT1-MMP as a therapeutic target for invasive tumors.
Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2.
Serum Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) mRNA Protected by Exosomes as a Potential Biomarker for Gastric Cancer.
Shedding of RANKL by tumor-associated MT1-MMP activates Src-dependent prostate cancer cell migration.
Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder.
Significance of membrane type 1 matrix metalloproteinase expression in breast cancer.
Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer.
Simultaneous presence of unsaturation and long alkyl chain at P'1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies.
Single Nucleotide Polymorphisms and Haplotypes of MMP-14 are Associated with the Risk and Pathological Development of Oral Cancer.
Single-nucleotide polymorphisms and haplotypes of membrane type 1-matrix metalloproteinase in susceptibility and clinical significance of squamous cell neoplasia of uterine cervix in taiwan women.
SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT/GSK-3?/?-catenin pathway.
Small leucine-rich proteoglycans and matrix metalloproteinase-14: Key partners?
Soluble Lutheran/basal cell adhesion molecule is detectable in plasma of hepatocellular carcinoma patients and modulates cellular interaction with laminin-511 in vitro.
Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44.
SPOCK2 Affects the Biological Behavior of Endometrial Cancer Cells by Regulation of MT1-MMP and MMP2.
Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration.
Stable expression of ?1-antitrypsin Portland in MDA-MB-231 cells increased MT1-MMP and MMP-9 levels, but reduced tumour progression.
Stimulation of MMP-11 (stromelysin-3) expression in mouse fibroblasts by cytokines, collagen and co-culture with human breast cancer cell lines.
Strategies of chemoprevention based on antigenic and molecular markers of early and premalignant lesions of the bladder.
Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice.
Stromal expression of c-Ets1 transcription factor correlates with tumor invasion.
Stromelysin-3 induction and interstitial collagenase repression by retinoic acid. Therapeutical implication of receptor-selective retinoids dissociating transactivation and AP-1-mediated transrepression.
Structural Studies of Matrix Metalloproteinase by X-Ray Diffraction.
Suppressing TGF? Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer.
Suppression of hepatic fat accumulation by highly purified eicosapentaenoic acid prevents the progression of d-galactosamine-induced hepatitis in mice fed with a high-fat/high-sucrose diet.
Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through ?2?1 integrin and MT1-MMP.
Synergistic metalloproteinase-based remodeling of matrix by pancreatic tumor and stromal cells.
Synovial fluid levels of TWEAK and matrix metalloproteinase 1 in patients with osteoarthritis, and associations with disease severity.
Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines.
Synthesis, Kinetic Characterization and Metabolism of Diastereomeric 2-(1-(4-Phenoxyphenylsulfonyl)ethyl)thiiranes as Potent Gelatinase and MT1-MMP Inhibitors.
Tagitinin F has anti-inflammatory, anti-nociceptive and anti-matrix metalloproteinase properties: An in silico, in vitro and in vivo study.
Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer.
Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.
Targeting Extracellular Matrix Remodeling restores BRAF Inhibitor Sensitivity in BRAFi Resistant Melanoma.
Targeting MMP-14 for dual PET and fluorescence imaging of glioma in preclinical models.
Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas.
Targeting the tumor microenvironment with chemically modified tetracyclines: inhibition of laminin 5 gamma2 chain promigratory fragments and vasculogenic mimicry.
Targeting the warburg effect, which arises in tumor cells expressing membrane-type-1 matrix metalloproteinase.
Teneligliptin inhibits IL-1?-induced degradation of extracellular matrix in human chondrocytes.
Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis.
TGF-?1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells.
TGF-?1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-linking.
The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment.
The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs.
The chondroprotective drugs, Arteparon and sodium pentosan polysulphate, increase collagenase activity and inhibit stromelysin activity in vitro.
The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer.
The clinicopathological and prognostic significance of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-9 according to their localization in invasive breast carcinoma.
The collagenase activities, interstitial collagenase and type IV collagenase, in human stomach cancer: with special reference to local spreading and lymph node metastasis.
The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein.
The differential regulation of human telomerase reverse transcriptase and vascular endothelial growth factor may contribute to the clinically more aggressive behavior of p63-positive breast carcinomas.
The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression.
The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors.
The Expanding Role of MT1-MMP in Cancer Progression.
The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis.
The expression of MMP-14 and microRNA-410 in FFPE tissues of human endometrial adenocarcinoma.
The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression.
The HIV protease inhibitor indinavir down-regulates the expression of the pro-angiogenic MT1-MMP by human endothelial cells.
The influence of CD44v3-v10 on adhesion, invasion and MMP-14 expression in prostate cancer cells.
The influence of MMP-14, TIMP-2 and MMP-2 expression on breast cancer prognosis.
The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis.
The Oncogenic Response to MiR-335 Is Associated with Cell Surface Expression of Membrane-Type 1 Matrix Metalloproteinase (MT1-MMP) Activity.
The phosphoinositide-binding protein ZF21 regulates ECM degradation by invadopodia.
The polymorphism MMP1 -1607 (1G>2G) is associated with a significantly increased risk of cancers from a meta-analysis.
The Precise Diagnosis of Cancer Invasion/Metastasis via 2D Laser Ablation Mass Mapping of Metalloproteinase in Primary Cancer Tissue.
The prognostic value of metalloproteinases and angiogenic factors in ovarian carcinoma.
The role of MMP-14 in ovarian cancer: a systematic review.
The role of MT2-MMP in cancer progression.
The role of stromal cells in the expression of interstitial collagenase (matrix metalloproteinase-1) in the invasion of gastric cancer.
The role of the IGF-I receptor in the regulation of matrix metalloproteinases, tumor invasion and metastasis.
The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination.
The type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells.
Three-dimensional coculture of endometrial cancer cells and fibroblasts in human placenta derived collagen sponges and expression matrix metalloproteinases in these cells.
Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2.
Tight junction protein claudin-1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin-5 gamma2 chain via matrix metalloproteinase (MMP)-2 and membrane-type MMP-1.
TIMP-1 induces an EMT-like phenotypic conversion in MDCK cells independent of its MMP-inhibitory domain.
TIMP-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells.
TIMP-2 fusion protein with human serum albumin potentiates anti-angiogenesis-mediated inhibition of tumor growth by suppressing MMP-2 expression.
TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis.
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway.
Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines.
Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.
Tissue inhibitor of metalloproteinase-2 regulates matrix metalloproteinase-2-mediated endothelial barrier dysfunction and breast cancer cell transmigration through lung microvascular endothelial cells.
Tissue inhibitor of metalloproteinase-I and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes.
Tissue inhibitor of metalloproteinases-1 (TIMP-1) RNA is expressed at elevated levels in malignant non-Hodgkin's lymphomas.
Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism.
Tissue microarrays of human tumor xenografts: characterization of proteins involved in migration and angiogenesis for applications in the development of targeted anticancer agents.
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.
Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.
Toll-Like Receptor 3 Deficiency Leads to Altered Immune Responses to Chlamydia trachomatis Infection in Human Oviduct Epithelial Cells.
TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion.
Transformation of epithelial Madin-Darby canine kidney cells with p60(v-src) induces expression of membrane-type 1 matrix metalloproteinase and invasiveness.
Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase.
Transient collagen triple helix binding to a key metalloproteinase in invasion and development.
Transient increase of intracellular cAMP by heat shock initiates the suppression of MT1-MMP production in tumor cells.
Transmigration of human ovarian adenocarcinoma cells through endothelial extracellular matrix involves alphav integrins and the participation of MMP2.
Treatment of rheumatoid synovitis with anti-reshaping human interleukin-6 receptor monoclonal antibody: use of rheumatoid arthritis tissue implants in the SCID mouse model.
Tube travel: the role of proteases in individual and collective cancer cell invasion.
Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling.
Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase.
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis.
Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP.
Tumor cell-derived collagenase-stimulatory factor increases expression of interstitial collagenase, stromelysin, and 72-kDa gelatinase.
Tumor cell-matrix interaction: pericellular matrix degradation and metastasis.
Tumor collagenase stimulating factor (TCSF) and tumor autocrine motility factor (TAMF) in bladder cancer.
Tumor collagenase stimulatory factor (TCSF) expression and localization in human lung and breast cancers.
Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cells.
Tumor necrosis factor-alpha stimulates the biosynthesis of matrix metalloproteinases and plasminogen activator in cultured human chorionic cells.
Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts.
Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes.
Tumor-derived death receptor 6 modulates dendritic cell development.
Tumor-stroma interactions of metastatic prostate cancer cell lines: analyses using microarrays.
Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis.
Tumour-targeting properties of antibodies specific to MMP-1A, MMP-2 and MMP-3.
Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation.
Twist is required for thrombin-induced tumor angiogenesis and growth.
Two-step sandwich enzyme immunoassay using monoclonal antibodies for detection of soluble and membrane-associated human membrane type 1-matrix metalloproteinase.
Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.
Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma.
Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis.
Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett's oesophageal adenocarcinoma.
Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: a major induction of stromal MMP-13.
Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line.
Use of a novel camelid-inspired human antibody demonstrates the importance of MMP-14 to cancer stem cell function in the metastatic process.
v-src activation of the collagenase-1 (matrix metalloproteinase-1) promoter through PEA3 and STAT: requirement of extracellular signal-regulated kinases and inhibition by retinoic acid receptors.
Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas.
Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway.
Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging.
When MT1-MMP meets ADAMs.
[Changes of lymphatic vessel density in lung adenocarcinoma in situ, minimally invasive adenocarcinoma, and invasive adenocarcinoma and the regulatory factors].
[Construction and expression of hTNF-alpha fusion protein mediated by MMP1].
[Correlation between MMP-2 activation and MT1-MMP mRNA expression in thymic epithelial tumors]
[Correlation of membrane type I matrix metalloproteinase (MT1-MMP) expression with clinicomorphological features of tumor front in squamous cell carcinoma of the larynx]
[Dectection and analysis of miRNA expression in breast cancer-associated fibroblasts].
[Effect of bone morphogenetic protein-2 on the expression of membrane Type 1-matrix metalloproteinase in human A549 lung carcinoma cells]
[Effects of MT1-MMP on the in vitro invasiveness of breast cancer cells]
[Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal neoplasm]
[Expression of membrane-type I matrix metalloproteinase and its correlation with gelatinase A activation in cancer cell lines]
[Expression of MT1-MMP and its significance in rabbit VX2 tumor tissues after transarterial embolization with hydroxyapatite nanoparticles]
[Expression pattern of membrane type-1 matrix metalloproteinase in primary breast carcinomas].
[Impact of biological function on ovarian clear cell carcinoma ES2 cell line with ARID1A gene expression down-regulating in vitro].
[Implication of VEGF and MMPs in hepatic metastasis of human colon cancer]
[Interstitial collagenase and their endogenous regulators in squamous cell cervical carcinoma].
[Interstitial collagenase, gelatinases A and B and their endogenous inhibitors in squamous cell cervical carcinomas].
[Matrix metalloproteinases and their endogenous regulators in squamous cervical carcinoma (review of the own data)].
[Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas.]
[Morphological tumor front grading and matrix metalloproteinases type I expression as a prognostic parameter of the presence of lymph node micrometastases in laryngeal carcinoma]
[MT1-MMP up-regulates VEGF expression in human breast carcinoma MCF-7 cells and induces tumor angiogenesis]
[Progress on evaluation criterion of wound healing]
[Relationship of the disturbed balance between matrix metalloproteinases and their tissue inhibitors and the invasion of malignant salivary gland tumours]
[Significance of membrane type-1 matrix metalloproteinase expression in breast cancer]
[The expressions of TNF-alpha and MMP-9 in serum and MMP-1 mRNA in the bone tissue in chronic obstructive pulmonary disease patients of cold dryness syndrome in northwest China].
[The role of matrixmetalloproteinases in the tumor growth and metastasis].
[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].
[Virtual screening and molecular simulations of antisense peptides targeting MT1-MMP].
Neoplastic Cells, Circulating
Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas.
Matrix metalloproteinase 1 and circulating tumor cells in early breast cancer.
Nephritis, Hereditary
Increased expression of MMP-2, MMP-9 (type IV collagenases/gelatinases), and MT1-MMP in canine X-linked Alport syndrome (XLAS).
Nephrosclerosis
Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence.
Neuralgia
Matrix Metalloproteinase-14 Both Sheds Cell Surface Neuronal Glial Antigen 2 (NG2) Proteoglycan on Macrophages and Governs the Response to Peripheral Nerve Injury.
Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.
Neurilemmoma
Expression of emmprin and matrix metalloproteinases (MMPs) in peripheral nerve sheath tumors: emmprin and membrane-type (MT)1-MMP expressions are associated with malignant potential.
Neuroblastoma
Assessment of the MT1-MMP expression level of different cell lines by the naked eye.
Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis.
Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14.
Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression.
microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells.
miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14.
Two transcription factors, E1AF and N-myc, correlate with the invasiveness of neuroblastoma cell lines.
Neurodegenerative Diseases
Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
MMP-14 overexpression correlates with the neurodegenerative process in familial amyloidotic polyneuropathy.
Neuroendocrine Tumors
Expression of c-ets-1, collagenase 1, and urokinase-type plasminogen activator genes in lung carcinomas.
Neurofibroma
Expression of emmprin and matrix metalloproteinases (MMPs) in peripheral nerve sheath tumors: emmprin and membrane-type (MT)1-MMP expressions are associated with malignant potential.
Metalloproteinase 1 downregulation in neurofibromatosis 1: Therapeutic potential of antimalarial hydroxychloroquine and chloroquine.
Neurofibromatosis 1
Metalloproteinase 1 downregulation in neurofibromatosis 1: Therapeutic potential of antimalarial hydroxychloroquine and chloroquine.
Neuroma, Acoustic
MMP-14 (MT1-MMP) Is a Biomarker of Surgical Outcome and a Potential Mediator of Hearing Loss in Patients With Vestibular Schwannomas.
Nevus
Coordinate expression of membrane type-matrix metalloproteinases-2 and 3 (MT2-MMP and MT3-MMP) and matrix metalloproteinase-2 (MMP-2) in primary and metastatic melanoma cells.
Implication of MT1-MMP in the maturation steps of benign melanocytic nevi.
MT1-MMP modulates melanoma cell dissemination and metastasis through activation of MMP2 and RAC1.
Nevus, Intradermal
Implication of MT1-MMP in the maturation steps of benign melanocytic nevi.
Nevus, Pigmented
Implication of MT1-MMP in the maturation steps of benign melanocytic nevi.
MMP-2, TIMP-2 and MT1-MMP are differentially expressed in lesional skin of melanocytic nevi and their expression is modulated by UVB-light.
Obesity
Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans.
Obstetric Labor, Premature
Changes in gene expression of cervical collagens, metalloproteinases, and tissue inhibitors of metalloproteinases after partial cervical excision-induced preterm labor in mice.
Distinct molecular events suggest different pathways for preterm labor and premature rupture of membranes.
Odontogenic Cysts
Interleukin-1alpha enhances type I collagen-induced activation of matrix metalloproteinase-2 in odontogenic keratocyst fibroblasts.
Odontogenic Tumors
Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors.
Osteoarthritis
A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death.
Analysis for the major contributor of collagenase to the primary cleavage of type II collagens in cartilage degradation.
Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression.
Cloning of collagenase 3 from the synovial membrane and its expression in rheumatoid arthritis and osteoarthritis.
Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis.
Effects of MMP-1 1G/2G polymorphism on osteoarthritis: A meta-analysis study.
Immobilized anti-CD3 antibody activates T cell clones to induce the production of interstitial collagenase, but not tissue inhibitor of metalloproteinases, in monocytic THP-1 cells and dermal fibroblasts.
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis.
Induction of matrix metalloproteinase 1 gene expression is regulated by inflammation-responsive transcription factor SAF-1 in osteoarthritis.
Role of eicosanoids in structural degradation in osteoarthritis.
Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors.
Synovial fluid levels of TWEAK and matrix metalloproteinase 1 in patients with osteoarthritis, and associations with disease severity.
Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines.
Testican-1, an inhibitor of pro-MMP-2 activation, is expressed in cartilage.
The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk.
The effects of tenidap on canine experimental osteoarthritis: II. Study of the expression of collagenase-1 and interleukin 1beta by in situ hybridization.
The involvement of matrix metalloproteinases and inflammation in lumbar disc herniation.
Variation of Matrix Metalloproteinase 1 and 3 Haplotypes and Their Serum Levels in Patients with Rheumatoid Arthritis and Osteoarthritis.
Osteolysis
ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling.
Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders.
Genetic susceptibility to aseptic loosening following total hip arthroplasty: a systematic review.
Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas.
Shedding of RANKL by tumor-associated MT1-MMP activates Src-dependent prostate cancer cell migration.
Osteonecrosis
MMP-14 single-nucleotide polymorphisms are related to steroid-induced osteonecrosis of the femoral head in the population of northern China.
Osteoporosis
Investigation of the relationship between osteoporosis and the collagenase gene by means of polymorphism of the 5'upstream region of this gene.
Membrane-type matrix metalloproteinase-1 (MT1-MMP) is down-regulated in estrogen-deficient rat osteoblast in vivo.
Osteosarcoma
A furin inhibitor downregulates osteosarcoma cell migration by downregulating the expression levels of MT1-MMP via the Wnt signaling pathway.
Co-localisation of intra-nuclear membrane type-1 matrix metalloproteinase and hypoxia inducible factor-2? in osteosarcoma and prostate carcinoma cells.
Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner.
Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis.
Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma.
Influence of ?-catenin small interfering RNA on human osteosarcoma cells.
Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate.
Matrix Metalloproteinase 1 promotes tumor formation and lung metastasis in an intratibial injection osteosarcoma mouse model.
Parathyroid hormone induction of rat interstitial collagenase mRNA in osteosarcoma cells is mediated through an AP-1-binding site.
Pigment epithelium-derived factor upregulates collagen I and downregulates matrix metalloproteinase 2 in osteosarcoma cells, and colocalises to collagen I and heat shock protein 47 in fetal and adult bone.
Recombinant matrix metalloproteinase-14 catalytic domain induces apoptosis in human osteoblastic SaOS-2 cells.
Retinoic acid stimulates interstitial collagenase messenger ribonucleic acid in osteosarcoma cells.
Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis.
Otitis Media
Serum matrix metalloproteinases and tympanosclerosis.
Ovarian Cysts
Study on matrix metalloproteinase 1 and 2 gene expression and NO in dairy cows with ovarian cysts.
Ovarian Neoplasms
Construction of antisense MT1-MMP vector and its inhibitory effects on invasion of human ovarian cancer cells.
Down-regulation of MT1-MMP expression suppresses tumor cell invasion in metastatic human SW626 ovarian cancer cells.
Epidermal growth factor receptor-mediated membrane type 1 matrix metalloproteinase endocytosis regulates the transition between invasive versus expansive growth of ovarian carcinoma cells in three-dimensional collagen.
Expression of matrix metalloproteinases (MMP-2, MMP-9, MT1-MMP) and their inhibitors (TIMP-1, TIMP-2) in common epithelial tumors of the ovary.
Gonadotropin-releasing hormone-II increases membrane type I metalloproteinase production via beta-catenin signaling in ovarian cancer cells.
Hypoxia promotes HO-8910PM ovarian cancer cell invasion via Snail-mediated MT1-MMP upregulation.
Limited independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer.
Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium.
MMP-14 and CD44 in Epithelial-to-Mesenchymal Transition (EMT) in ovarian cancer.
MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells.
Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination.
PEA3 is necessary for optimal epidermal growth factor receptor-stimulated matrix metalloproteinase expression and invasion of ovarian tumor cells.
Phagocytosis of collagen by fibroblasts and invasive cancer cells is mediated by MT1-MMP.
Polymorphisms in MMP-14 and MMP-2 genes and ovarian cancer survival.
Post-translational modification of the membrane type 1 matrix metalloproteinase (MT1-MMP) cytoplasmic tail impacts ovarian cancer multicellular aggregate dynamics.
Primary Ovarian Tumors With Lymphogenic and Hematogenic Metastasis Express High MMP-14, Which Colocalizes With Highly Sulfated Chondroitin Sulfate in the Stroma.
Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis and tumor growth in ovarian cancer.
The role of MMP-14 in ovarian cancer: a systematic review.
[Inhibitory effect of MT1-MMP antisense nucleotide on invasion of human highly metastatic ovarian cancer cell line SW626.]
Pancreatic Neoplasms
Anti-tumor effect and mechanism of cyclooxygenase-2 inhibitor through matrix metalloproteinase 14 pathway in PANC-1 cells.
CD44 regulates pancreatic cancer invasion through MT1-MMP.
Localization of collagenase at the basal plasma membrane of a human pancreatic carcinoma cell line.
Matrix metalloproteinase-14 is a mechanically regulated activator of secreted MMPs and invasion.
MT1-MMP as a PET Imaging Biomarker for Pancreas Cancer Management.
MT1-MMP cooperates with KrasG12D to promote pancreatic fibrosis through increased TGF-{beta} signaling.
MT1-MMP-Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy.
Re-expression of miR-200 by novel approaches regulates the expression of PTEN and MT1-MMP in pancreatic cancer.
Role of MT-MMPs and MMP-2 in pancreatic cancer progression.
The Roles of Matrix Metalloproteinases in Pancreatic Cancer.
Pancreatitis
Long-term overexpression of membrane type-1 matrix metalloproteinase and matrix metalloproteinase-2 in oleic acid-induced pancreatitis in rats.
Pancreatitis, Chronic
Role of MT-MMPs and MMP-2 in pancreatic cancer progression.
Papilloma
Imatinib-associated matrix metalloproteinase suppression in p16-positive squamous cell carcinoma compared to HPV-negative HNSCC cells in vitro.
Peri-Implantitis
Characteristics of collagenase-2 from gingival crevicular fluid and peri-implant sulcular fluid in periodontitis and peri-implantitis patients: pilot study.
Periodontal Diseases
Involvement of MT1-MMP and TIMP-2 in human periodontal disease.
MMP-2 activation by Actinobacillus actinomycetemcomitans supernatant in human PDL cells was corresponded with reduction of TIMP-2.
Periodontal Pocket
Collagenase activity in gingival crevicular fluid of patients with juvenile periodontitis.
Effect of dental cyst epithelium-conditioned medium on collagenase production by periodontal ligament fibroblasts.
Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis.
Periodontitis
Associations between matrix metalloproteinase-8 and -14 and myeloperoxidase in gingival crevicular fluid from subjects with progressive chronic periodontitis: a longitudinal study.
Membrane type (MT) 1-matrix metalloproteinase (MMP) and MMP-2 expression in ligature-induced periodontitis in the rat.
Role of fibroblast populations in peri-implantitis.
The relationship between mouthrinse matrix metalloproteinases (MMP-1, 8, 13) and albumin levels with the degree of oral mucositis in allogeneic stem cell transplant patients.
Pituitary Neoplasms
Metalloproteinases ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas.
MMP-14 and TGF?-1 methylation in pituitary adenomas.
Selective estrogen receptor modulators decrease invasiveness in pituitary adenoma cell lines AtT-20 and TtT/GF by affecting expression of MMP-14 and ADAM12.
Pneumonia
Leukotriene C4 upregulates collagenase expression and synthesis in human lung fibroblasts.
[The analysis of amount of matrix metalloproteinase 1 precursor, metalloproteinase 1 tissue inhibitor and cystatin C in the bronchoalveolar secretion of patients with nonspecific lung diseases].
Polycystic Kidney Diseases
Matrix metalloproteinases synthesized in autosomal dominant polycystic kidney disease play a role in development of a concurrent abdominal aortic aneurysm.
Polycystic Kidney, Autosomal Dominant
Matrix metalloproteinases synthesized in autosomal dominant polycystic kidney disease play a role in development of a concurrent abdominal aortic aneurysm.
Sirolimus ameliorates the enhanced expression of metalloproteinases in a rat model of autosomal dominant polycystic kidney disease.
Polyhydramnios
Amniotic fluid concentrations of collagenase-1 and collagenase-3 are increased in polyhydramnios.
Polymyositis
Expression of specific matrix metalloproteinases in inflammatory myopathies.
Polyneuropathies
MMP-14 overexpression correlates with the neurodegenerative process in familial amyloidotic polyneuropathy.
Pre-Eclampsia
Analyses of soluble endoglin and matrix metalloproteinase 14 using enzyme-linked immunosorbent assay in the diagnosis and assessment of severity of early- and late-onset pre-eclampsia
Gene expression analysis of MMPs in women with preeclampsia using cell-free fetal RNA in maternal plasma.
Matrix metalloproteinase 1 in pre-eclampsia and fetal growth restriction: reduced gene expression in decidual tissue and protein expression in extravillous trophoblasts.
MMP-14 aggravates onset of severe preeclampsia by mediating soluble endoglin release.
MMP-14 Is Expressed in Preeclamptic Placentas and Mediates Release of Soluble Endoglin.
MMP-15 is upregulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin.
Pregnancy, Tubal
Co-ordinated expression of MMP-2 and its putative activator, MT1-MMP, in human placentation.
Membrane-type 1 matrix metalloproteinase is induced in decidual stroma without direct invasion by trophoblasts.
Pressure Ulcer
Nutritional markers, acute phase reactants and tissue inhibitor of matrix metalloproteinase 1 in elderly patients with pressure sores.
Prostatic Hyperplasia
Dual-functions of miR-373 and miR-520c by differently regulating the activities of MMP2 and MMP9.
Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression.
Prostatic Intraepithelial Neoplasia
Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia.
Prostatic Neoplasms
Differential localization of MT1-MMP in human prostate cancer tissue: Role of IGF-1R in MT1-MMP expression.
Effect of hepatocyte growth factor on invasion of prostate cancer cell lines.
Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression.
Expression and functional role of CCR9 in prostate cancer cell migration and invasion.
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) on prostate cancer cell lines.
Increased Aggressiveness of Human Prostate PC-3 Tumor Cells Expressing Cell Surface Localized Membrane Type-1 Matrix Metalloproteinase (MT1-MMP).
Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors.
LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells.
Loss of P53 facilitates invasion and metastasis of prostate cancer cells.
Lumican expression, localization and antitumor activity in prostate cancer.
Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration.
Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia.
Membrane type 1-matrix metalloproteinase promotes human prostate cancer invasion and metastasis.
Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 beta3 chain and induces cell migration.
Membrane-type 1 matrix metalloproteinase is regulated by sp1 through the differential activation of AKT, JNK, and ERK pathways in human prostate tumor cells.
OXIDATIVE STRESS AND PROSTATE CANCER PROGRESSION ARE ELICITED BY MEMBRANE-TYPE 1 MATRIX METALLOPROTEINASE (MT1-MMP).
Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP.
Prostate Cancer-Associated Membrane Type 1-Matrix Metalloproteinase. A Pivotal Role in Bone Response and Intraosseous Tumor Growth.
Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth.
Roles of matrix metalloproteinases and their natural inhibitors in prostate cancer progression.
Shedding of RANKL by tumor-associated MT1-MMP activates Src-dependent prostate cancer cell migration.
The influence of CD44v3-v10 on adhesion, invasion and MMP-14 expression in prostate cancer cells.
Tumor-stroma interactions of metastatic prostate cancer cell lines: analyses using microarrays.
Underexpression of MMP-2 and its regulators, TIMP2, MT1-MMP and IL-8, is associated with prostate cancer.
VCA nanobodies target N-WASp to reduce invadopodium formation and functioning.
[Expression of membrane-type I matrix metalloproteinase and its correlation with gelatinase A activation in cancer cell lines]
[Inhibitory effect of 3-bromopyruvate on the proliferation, migration and invasive ability of prostate cancer PC-3 cells].
[Prognostic value of stromal immunolabelling by MMP-2, MT1-MMP and TIMP-2 in clinically localized prostate cancer]
Proteinuria
Macrophage-derived MT1-MMP and increased MMP-2 activity are associated with glomerular damage in crescentic glomerulonephritis.
Pterygium
Differential expression of matrix metalloproteinases and their tissue inhibitors at the advancing pterygium head.
UVB-elicited induction of MMP-1 expression in human ocular surface epithelial cells is mediated through the ERK1/2 MAPK-dependent pathway.
Pulmonary Disease, Chronic Obstructive
Activity of matrix metalloproteinase in airway epithelial cells of COPD patients.
Expression of matrix metalloproteinase-1 in alveolar macrophages, type II pneumocytes, and airways in smokers: relationship to lung function and emphysema.
Expression of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, and Changes in Alveolar Septa in Patients with Chronic Obstructive Pulmonary Disease.
MMP-9 as a marker of inflammation in tracheal epithelial lining fluid (TELF) and in bronchoalveolar fluid (BALF) of COPD horses.
Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD.
[Complex search for antiprotease-protease enzyme gene polymorphisms in patients with chronic obstructive pulmonary diseases]
[Study on matrix metalloproteinase 1, 9, 12 polymorphisms and susceptibility to chronic obstructive pulmonary disease among Han nationality in northern China]
[The analysis of amount of matrix metalloproteinase 1 precursor, metalloproteinase 1 tissue inhibitor and cystatin C in the bronchoalveolar secretion of patients with nonspecific lung diseases].
[The expressions of TNF-alpha and MMP-9 in serum and MMP-1 mRNA in the bone tissue in chronic obstructive pulmonary disease patients of cold dryness syndrome in northwest China].
Pulmonary Emphysema
Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke.
Pulmonary Fibrosis
Loss of MT1-MMP in Alveolar Epithelial Cells Exacerbates Pulmonary Fibrosis.
Role of MMP-2 in alveolar epithelial cell repair after bleomycin administration in rabbits.
[mRNA expression of matrix metalloproteinase-2 and membrane type matrix metalloproteinase in pulmonary fibroblasts and macrophages of rat pulmonary fibrosis model]
Pulpitis
Metalloproteinase 14 (MMP-14) and hsa-miR-410-3p expression in human inflamed dental pulp and odontoblasts.
Radicular Cyst
Immunolocalization of interstitial collagenase (MMP-1) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in radicular cysts.
Reperfusion Injury
Fibronectin-?4?1 Interactions in Hepatic Cold Ischemia and Reperfusion Injury: Regulation of MMP-9 and MT1-MMP via the p38 MAPK Pathway.
Respiratory Insufficiency
Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice.
Retinoblastoma
Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblasts.
Root Resorption
Expression of MT1-MMP during deciduous tooth resorption in odontoclasts.
Sarcoglycanopathies
Cleavage of ?-dystroglycan occurs in sarcoglycan-deficient skeletal muscle without MMP-2 and MMP-9.
Sarcoma
Expression and activity of vascular endothelial growth factor and metalloproteinases in alveolar and embryonal rhabdomyosarcoma cell lines.
Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes.
Local activity of matrix metalloproteinases in a case of botryoid sarcoma.
Matrix metalloproteinase 1: role in sarcoma biology.
Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities.
MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins.
Sarcoma, Ewing
DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma.
Regulatory network of differentially expressed genes in metastatic osteosarcoma.
Scleroderma, Diffuse
Serum TIMP-1, TIMP-2, and MMP-1 in patients with systemic sclerosis, primary Raynaud's phenomenon, and in normal controls.
Scleroderma, Localized
Induction of interstitial collagenase (MMP-1) by UVA-1 phototherapy in morphea fibroblasts.
Scleroderma, Systemic
Serum TIMP-1, TIMP-2, and MMP-1 in patients with systemic sclerosis, primary Raynaud's phenomenon, and in normal controls.
Seizures
Focal adhesion molecules regulate astrocyte morphology and glutamate transporters to suppress seizure-like behavior.
Seminoma
[Correlation between expression of metastasis-related genes and lymph node metastasis in testicular cancer]
Sepsis
Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases.
Silicosis
Egr-1 mediates Si0(2)-driven transcription of membrane type I matrix metalloproteinase in macrophages.
Skin Diseases
Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin.
Interstitial collagenase is expressed by keratinocytes that are actively involved in reepithelialization in blistering skin disease.
Skin Neoplasms
Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers.
Increased expression of stromelysin-3 in basal cell carcinomas.
The tetraspanin CD81 protein increases melanoma cell motility by up-regulating metalloproteinase MT1-MMP expression through the pro-oncogenic Akt-dependent Sp1 activation signaling pathways.
Squamous Cell Carcinoma of Head and Neck
Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma.
Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysis.
Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer.
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis.
Expression of MMP-7 and MT1-MMP in oral squamous cell carcinoma as predictive indicator for tumor invasion and prognosis.
Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo.
Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells.
Identification of a novel therapeutic target for head and neck squamous cell carcinomas: a role for the neurotensin-neurotensin receptor 1 oncogenic signaling pathway.
Increased expression of membrane type 1-matrix metalloproteinase in head and neck carcinoma.
Interstitial collagenase gene expression in oral squamous cell carcinoma.
Key proteins of invadopodia are overexpressed in oral squamous cell carcinoma suggesting an important role of MT1-MMP in the tumoral progression.
Matrix metalloproteases in head and neck cancer.
Matrix metalloproteinase-2 and -14 in p16-positive and -negative HNSCC after exposure To 5-FU and docetaxel In Vitro.
Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells.
Metaanalysis of the significance of matrix metalloproteinases for lymph node disease in patients with head and neck squamous cell carcinoma.
MT1-MMP and MMP-7 in invasion and metastasis of human cancers.
PLAU1 Facilitated Proliferation, Invasion, and Metastasis via Interaction With MMP1 in Head and Neck Squamous Carcinoma.
Podoplanin promotes the invasion of oral squamous cell carcinoma in coordination with MT1-MMP and Rho GTPases.
Single Nucleotide Polymorphisms and Haplotypes of MMP-14 are Associated with the Risk and Pathological Development of Oral Cancer.
[Correlation of membrane type I matrix metalloproteinase (MT1-MMP) expression with clinicomorphological features of tumor front in squamous cell carcinoma of the larynx]
[Expression levels of MMP-14, ING4 and HIF-1? in 60 patients with oral squamous cell carcinoma and their clinical significance].
[Expression of MMP1 mRNA in oral squamous cell carcinoma and paired normal tissues]
Starvation
mTOR Repression in Response to Amino Acid Starvation Promotes ECM Degradation Through MT1-MMP Endocytosis Arrest.
TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis.
Stomach Neoplasms
A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases.
Analysis of MT1-MMP and MMP2 expression in human gastric cancers.
Balance between polyoma enhancing activator 3 and activator protein 1 regulates Helicobacter pylori-stimulated matrix metalloproteinase 1 expression.
Clinical and experimental role of ring finger protein 180 on lymph node metastasis and survival in gastric cancer.
Clinical significance of MT1-MMP mRNA expression in breast cancer.
Clinical significance of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric cancer.
Combined features based on MT1-MMP expression, CD11b + immunocytes density and LNR predict clinical outcomes of gastric cancer.
Contribution of matrix metalloproteinases-1 genotypes to gastric cancer susceptibility in Taiwan.
Decreased MT1-MMP in gastric cancer suppressed cell migration and invasion via regulating MMPs and EMT.
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
Downregulation of annexin A7 decreases proliferation, migration, and invasion of gastric cancer cells by reducing matrix metalloproteinase 1 and 9 expression.
Downregulation of SFRP5 expression and its inverse correlation with those of MMP-7 and MT1-MMP in gastric cancer.
Effect of hGC-MSCs from human gastric cancer tissue on cell proliferation, invasion and epithelial-mesenchymal transition in tumor tissue of gastric cancer tumor-bearing mice.
Exosomes derived from miR-1228 overexpressing bone marrow-mesenchymal stem cells promote growth of gastric cancer cells.
Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer.
Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers.
Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation.
Expression of MMP-7 and MT1-MMP in peritoneal dissemination of gastric cancer.
High serum MMP-14 predicts worse survival in gastric cancer.
Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays.
Immunoexpression of Metalloproteinases 2 and 14 and TIMP-2 Inhibitor in Main Types of Primary Gastric Carcinomas and Lymph Node Metastasis.
Inhibition of CREPT restrains gastric cancer growth by regulation of cycle arrest, migration and apoptosis via ROS-regulated p53 pathway.
Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.
Letter regarding "MT1-MMP is not a good prognosticator of cancer survival: evidence from 11 studies" by Wu KP et al.
Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines.
Matrix metalloproteinase-1 (MMP-1) Promoter polymorphisms are well linked with lower stomach tumor formation in eastern Indian population.
Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer.
Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer.
miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14.
miRNA-584-3p inhibits gastric cancer progression by repressing Yin Yang 1- facilitated MMP-14 expression.
MT1-MMP is not a good prognosticator of cancer survival: evidence from 11 studies.
Role of interstitial collagenase gene promoter polymorphism in the etiology of gastric cancer.
The association between individual SNPs or haplotypes of matrix metalloproteinase 1 and gastric cancer susceptibility, progression and prognosis.
The collagenase activities, interstitial collagenase and type IV collagenase, in human stomach cancer: with special reference to local spreading and lymph node metastasis.
The role of MT2-MMP in cancer progression.
The role of stromal cells in the expression of interstitial collagenase (matrix metalloproteinase-1) in the invasion of gastric cancer.
Stomach Ulcer
Prolylhydroxylase and collagenase activities in the healing of acetic acid-induced gastric ulcers in rats and the effects of cimetidine and elcatonin.
Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing.
Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin.
Stomatitis, Aphthous
Effect of tetracyclines on collagenase activity in patients with recurrent aphthous ulcers.
Stroke
Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Tissue Inhibitor of Matrix Metalloproteinase 1 Increases With Ageing and Can Be Associated With Stroke?- Nested Case-Control Study.
superoxide dismutase deficiency
Age-dependent increases in interstitial collagenase and MAP Kinase levels are exacerbated by superoxide dismutase deficiencies.
Synovitis
Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis.
Tendinopathy
Increased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosis.
Thrombosis
Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin.
Expression changes and roles of matrix metalloproteinases in a rat model of traumatic deep vein thrombosis.
Granulocytes in coronary thrombus evolution after myocardial infarction - time-dependent changes in expression of matrix metalloproteinases.
Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix.
Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity.
Recanalization and flow regulate venous thrombus resolution and matrix metalloproteinase expression in vivo.
Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection.
Thymoma
Activation ratio of MMP-2 and expression of MT1-MMP are correlated in thymic epithelial tumours.
[Correlation between MMP-2 activation and MT1-MMP mRNA expression in thymic epithelial tumors]
Thyroid Cancer, Papillary
Matrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma of children and adolescents.
Thyroid Neoplasms
Expression of MMP-1 in invasive well-differentiated thyroid carcinoma.
Matrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma of children and adolescents.
mRNA levels of membrane-type 1 matrix metalloproteinase (MT1-MMP), MMP-2, and MMP-9 and of their inhibitors TIMP-2 and TIMP-3 in normal thyrocytes and thyroid carcinoma cell lines.
Purification of aminophenyl mercuryacetate-activated human matrix metalloproteinase 1 and removal of the organomercurial in a single-step chromatography.
Relaxin enhances the collagenolytic activity and in vitro invasiveness by upregulating matrix metalloproteinases in human thyroid carcinoma cells.
Tics
Conversion of stationary to invasive tumor initiating cells (TICs): role of hypoxia in membrane type 1-matrix metalloproteinase (MT1-MMP) trafficking.
Tooth Resorption
Expression of MT1-MMP during deciduous tooth resorption in odontoclasts.
Triple Negative Breast Neoplasms
A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models.
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.
Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function.
HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion.
Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance.
Tuberculosis
Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis.
Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis.
Urinary Bladder Neoplasms
Clinical significance and prognostic value of S100A4 and matrix metalloproteinase-14 in patients with organ-confined bladder cancer.
Dominative role of MMP-14 over MMP-15 in human urinary bladder carcinoma on the basis of its enhanced specific activity.
Effects of tumor necrosis factor-alpha and interferon-gamma on expressions of matrix metalloproteinase-2 and -9 in human bladder cancer cells.
p85? Inactivates MMP-2 and Suppresses Bladder Cancer Invasion by Inhibiting MMP-14 Transcription and TIMP-2 Degradation.
Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells.
Soluble Expression of Bladder Cancer Biomarker Matrix Metalloproteinase 1.
Tumor collagenase stimulating factor (TCSF) and tumor autocrine motility factor (TAMF) in bladder cancer.
Uterine Cervical Neoplasms
AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis.
E6/E7 oncoproteins of high risk HPV-16 upregulate MT1-MMP, MMP-2 and MMP-9 and promote the migration of cervical cancer cells.
Epidermal growth factor receptor regulates MT1-MMP and MMP-2 synthesis in SiHa cells via both PI3-K/AKT and MAPK/ERK pathways.
Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion.
HPV16 Oncoproteins Promote Cervical Cancer Invasiveness by Upregulating Specific Matrix Metalloproteinases.
Human Plasma Levels of Vascular Endothelial Growth Factor, Matrix Metalloproteinase 9, and Tissue Inhibitor of Matrix Metalloproteinase 1 and Their Applicability as Tumor Markers in Diagnoses of Cervical Cancer Based on ROC Analysis.
Matrix metalloproteinase 1 gene polymorphism as a prognostic predictor of invasive cervical cancer.
NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP.
Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis.
[Interstitial collagenase, gelatinases A and B and their endogenous inhibitors in squamous cell cervical carcinomas].
Vaccinia
Binding of active (57 kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 activation.
Vascular Diseases
Analysis of apolipoprotein A-I as a substrate for matrix metalloproteinase-14.
MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells.
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
Role of MT1-MMP in Estrogen-Mediated Cellular Processes of Intimal Hyperplasia.
Vascular System Injuries
Activation of MMP-2 in response to vascular injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP.
Wiskott-Aldrich Syndrome
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.
Xeroderma Pigmentosum
Overexpression of matrix metalloproteinase 1 in dermal fibroblasts from DNA repair-deficient/cancer-prone xeroderma pigmentosum group C patients.
Pretreatment of Ferulic Acid Protects Human Dermal Fibroblasts against Ultraviolet A Irradiation.