Information on EC 3.4.24.6 - leucolysin

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.4.24.6
-
RECOMMENDED NAME
GeneOntology No.
leucolysin
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Cleavage of Phe1-/-Val, His5-/-Leu, Ala14-/-Leu, Gly20-/-Glu, Gly23-/-Phe and Phe24-/-Phe bonds in insulin B chain as well as N-blocked dipeptides
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
endopeptidase
-
CAS REGISTRY NUMBER
COMMENTARY hide
72561-03-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
casein + H2O
hydrolyzed casein
show the reaction diagram
Hemoglobin + H2O
?
show the reaction diagram
-
-
-
-
?
Hemoglobin + H2O
Hydrolyzed hemoglobin
show the reaction diagram
insulin + H2O
?
show the reaction diagram
-
oxidized, B-chain
-
-
?
N-acetyl-Gly-Lys-OH + H2O
?
show the reaction diagram
-
-
-
-
?
N-acetyl-Gly-Lys-OMe + H2O
?
show the reaction diagram
-
-
-
-
?
N-acetyl-L-tyrosine ester + H2O
?
show the reaction diagram
-
-
-
-
?
N-Benzoyl-L-arginine ethyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl -Gly-Phe-NH3 + H2O
?
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl -Gly-Phe-OMe + H2O
?
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl -Gly-Trp-OH + H2O
?
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl -Gly-Tyr-OH + H2O
?
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl -Leu-Tyr-OH + H2O
?
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl -Trp-Trp-OH + H2O
?
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-Gly-Arg-OH + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized insulin B chain + H2O
?
show the reaction diagram
-
cleavage specificity towards Leu and Phe residues in the P1' position
-
-
?
poly-lysine + H2O
?
show the reaction diagram
-
-
-
-
?
poly-phenylalanine + H2O
?
show the reaction diagram
-
-
-
-
?
poly-tryptophan + H2O
?
show the reaction diagram
-
-
-
-
?
poly-tyrosine + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
no activity toward Bz-L-Arg-OEt or L-Leu-NHPhNO2
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
5 mM inhibits in the presence of 10 mM Ca2+
5,5'-dithiobis(2-nitrobenzoate)
-
-
cysteine
-
-
monoiodoacetate
-
-
N-ethylmaleimide
-
-
p-chloromercuribenzoate
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22400
-
sedimentation equilibrium
22500
-
sedimentation equilibrium
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
side-chain modification
-
glycoprotein
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
several weeks, 0-4°C
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE