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Information on EC 3.4.24.35 - gelatinase B and Organism(s) Mus musculus and UniProt Accession P41245

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.35 gelatinase B
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Select one or more organisms in this record: ?
This record set is specific for:
Mus musculus
UNIPROT: P41245 not found.
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Cleavage of gelatin types I and V and collagen types IV and V
Synonyms
mmp-9, matrix metalloproteinase-9, matrix metalloproteinase 9, gelatinase b, matrix metallopeptidase 9, matrix metalloprotease-9, mmp 9, 92-kda gelatinase, 92 kda gelatinase, 92-kda type iv collagenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
gelatinase
-
gelatinase B
-
Matrix metalloproteinase 9
-
matrix metalloproteinase-9
-
92 kDa gelatinase
-
-
-
-
92-kDa Gelatinase
-
-
-
-
92-kDa Type IV collagenase
-
-
-
-
95 kDa type IV collagenase/gelatinase
-
-
-
-
Collagenase IV
-
-
-
-
Collagenase type IV
-
-
-
-
gelatinase
-
-
Gelatinase MMP 9
-
-
-
-
GELB
-
-
-
-
Macrophage gelatinase
-
-
-
-
Matrix metalloproteinase 9
matrix metalloproteinase-9
MMP 9
-
-
-
-
MMP-9
Type IV collagen metalloproteinase
Type IV collagenase
-
-
-
-
Type IV collagenase/gelatinase
-
-
-
-
Type V collagenase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
146480-36-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Collagen + H2O
?
show the reaction diagram
-
-
-
?
dentin sialoprotein + H2O
?
show the reaction diagram
the enzyme highly efficiently cleaves dentin sialoprotein into distinct fragments in vitro, and the deletion of Mmp9 causes improper processing of dentin sialoprotein in natural teeth
-
-
?
Gelatin + H2O
?
show the reaction diagram
islet amyloid polypeptide + H2O
?
show the reaction diagram
enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide
-
-
?
vascular endothelial-cadherin + H2O
?
show the reaction diagram
-
-
-
?
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-beta-(2,4-dinitrophenylamino)Ala-Ala-Arg-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
60 S ribosomal protein L6 + H2O
?
show the reaction diagram
-
-
-
-
?
ADAM 2 + H2O
?
show the reaction diagram
-
putative protein substrate with potential cleavage site
-
?
aggrecan + H2O
?
show the reaction diagram
-
-
-
?
alpha 1(I) collagen + H2O
?
show the reaction diagram
-
-
-
?
alpha 1(V) collagen + H2O
?
show the reaction diagram
-
-
-
?
alpha 1(XI) collagen + H2O
?
show the reaction diagram
-
-
-
?
alpha 2(V) collagen + H2O
?
show the reaction diagram
-
-
-
?
alpha-amylase precursor + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-N-acetylglucosaminidase + H2O
?
show the reaction diagram
-
-
-
-
?
amyloid protein precursor + H2O
?
show the reaction diagram
-
-
-
-
?
amyloid-beta A4 protein precursor + H2O
?
show the reaction diagram
-
-
-
-
?
arylsulfatase B precursor + H2O
?
show the reaction diagram
-
-
-
-
?
beta-glucuronidase precursor + H2O
?
show the reaction diagram
-
-
-
-
?
beta-hexosaminidase beta chain precursor + H2O
?
show the reaction diagram
-
-
-
-
?
beta1-integrin + H2O
?
show the reaction diagram
-
-
-
-
?
beta2 integrin subunit CD18 + H2O
?
show the reaction diagram
-
-
-
-
?
Cartilage link protein + H2O
?
show the reaction diagram
-
-
-
?
cathepsin E precursor + H2O
?
show the reaction diagram
-
-
-
-
?
CB3 alpha 1(IV) collagen + H2O
?
show the reaction diagram
-
-
-
?
CD25 + H2O
?
show the reaction diagram
-
CD25 is proteolytic cleaved to its soluble form by MMP-9
-
-
?
CD316 antigen + H2O
?
show the reaction diagram
-
-
-
-
?
chondroitin sulfate proteoglycan + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen type I + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type II + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type IV + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type V + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type VII + H2O
?
show the reaction diagram
-
-
-
-
?
desmoglein 3 + H2O
?
show the reaction diagram
-
putative protein substrate with potential cleavage site
-
?
DGRNIYNIHVEDSLECVKGPNVAA + H2O
?
show the reaction diagram
-
-
-
-
?
ECVKGPNVAAIVGGT + H2O
ECVKGPNVAA + IVGGT
show the reaction diagram
-
-
-
-
?
Elastin + H2O
?
show the reaction diagram
endoglin + H2O
?
show the reaction diagram
-
putative protein substrate with potential cleavage site
-
?
endothilin receptor + H2O
?
show the reaction diagram
-
putative protein substrate with potential cleavage site
-
?
epididymis-specific alpha-mannosidase precursor + H2O
?
show the reaction diagram
-
-
-
-
?
Fibronectin + H2O
?
show the reaction diagram
-
-
-
-
?
galectin 3 + H2O
?
show the reaction diagram
-
-
-
?
Gelatin + H2O
?
show the reaction diagram
Golgi apparatus protein 1 precursor + H2O
?
show the reaction diagram
-
-
-
-
?
integrin beta5 + H2O
?
show the reaction diagram
-
putative protein substrate with potential cleavage site
-
?
interleukin-1beta + H2O
?
show the reaction diagram
-
-
-
-
?
kallikrein + H2O
?
show the reaction diagram
-
putative protein substrate with potential cleavage site
-
?
ladinin 1 + H2O
?
show the reaction diagram
-
putative protein substrate with potential cleavage site
-
?
Laminin + H2O
?
show the reaction diagram
-
-
-
-
?
laminin alpha3 chain + H2O
?
show the reaction diagram
-
putative protein substrate with potential cleavage site
-
?
lipase A + H2O
?
show the reaction diagram
-
-
-
-
?
myelin basic protein + H2O
?
show the reaction diagram
-
-
-
?
N-acetylglucosamine-6-sulfatase precursor + H2O
?
show the reaction diagram
-
-
-
-
?
N-cadherin + H2O
?
show the reaction diagram
-
-
-
-
?
pancreatic alpha-amylase isozyme + H2O
?
show the reaction diagram
-
-
-
-
?
peroxiredoxin 4 + H2O
?
show the reaction diagram
-
-
-
-
?
phosphate regulating neutral endopeptidase + H2O
?
show the reaction diagram
-
putative protein substrate with potential cleavage site
-
?
platelet factor 4 precursor + H2O
?
show the reaction diagram
-
-
-
-
?
pro-urokinase + H2O
active urokinase + prosequence of urokinase
show the reaction diagram
-
-
-
-
?
retinoic acid early inducible protein 1 alpha-precursor + H2O
?
show the reaction diagram
-
-
-
-
?
retinoid-inducible serine carboxypeptidase precursor + H2O
?
show the reaction diagram
-
-
-
-
?
SGFGSRYLTA + H2O
?
show the reaction diagram
-
-
-
?
SGKGPRQITA + H2O
?
show the reaction diagram
-
-
-
?
SGKIPRRLTA + H2O
?
show the reaction diagram
-
-
-
?
SGKIPRTATA + H2O
?
show the reaction diagram
-
-
-
?
SGKIPRTLTA + H2O
?
show the reaction diagram
-
-
-
?
SGLKALMITA + H2O
?
show the reaction diagram
-
-
-
-
?
SGLKAMITA + H2O
?
show the reaction diagram
-
-
-
?
SGLPAKSTA + H2O
?
show the reaction diagram
-
-
-
?
SGLRPAKSTA + H2O
?
show the reaction diagram
-
-
-
-
?
SGPLFYSVTA + H2O
?
show the reaction diagram
-
-
-
?
SGPRAVSTTA + H2O
?
show the reaction diagram
-
-
-
?
SGQPHYLTTA + H2O
?
show the reaction diagram
-
-
-
?
tissue factor pathway inhibitor + H2O
?
show the reaction diagram
-
-
-
?
transforming growth factor-beta + H2O
?
show the reaction diagram
-
MMP9 mediates activation of latent transforming growth factor-beta
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dentin sialoprotein + H2O
?
show the reaction diagram
the enzyme highly efficiently cleaves dentin sialoprotein into distinct fragments in vitro, and the deletion of Mmp9 causes improper processing of dentin sialoprotein in natural teeth
-
-
?
Gelatin + H2O
?
show the reaction diagram
-
-
-
?
islet amyloid polypeptide + H2O
?
show the reaction diagram
enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide
-
-
?
chondroitin sulfate proteoglycan + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type IV + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type V + H2O
?
show the reaction diagram
-
-
-
-
?
Elastin + H2O
?
show the reaction diagram
Fibronectin + H2O
?
show the reaction diagram
-
-
-
-
?
Laminin + H2O
?
show the reaction diagram
-
-
-
-
?
pro-urokinase + H2O
active urokinase + prosequence of urokinase
show the reaction diagram
-
-
-
-
?
transforming growth factor-beta + H2O
?
show the reaction diagram
-
MMP9 mediates activation of latent transforming growth factor-beta
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
MMP-9 inhibitor I
-
tissue inhibitor of metalloproteinases 1
TIMP-1
-
(R)-2-(N-((6-fluoropyridin-3-yl)methyl)-4-methoxyphenyl-sulfonamido)-N-hydroxy-3-methylbutanamide
-
-
(S)-2,4-bis[(2,3-dihydroxybenzoyl)amino]butyric acid methyl ester
-
-
(S)-2,5-bis[(2,3-dihydroxybenzoyl)amino]pentanoic acid methyl ester
-
-
(S)-2,6-bis[(2,3-dihydroxybenzoyl)amino]-N-hydroxyhexanoamide
-
-
(S)-2,6-bis[(2,3-dihydroxybenzoyl)amino]hexanenitrile
-
-
(S)-2,6-bis[(2,3-dihydroxybenzoyl)amino]hexanoamide
-
shows 33% inhibition against MMP-9 at 0.00025 mM
(S)-2,6-bis[(2,3-dihydroxybenzoyl)amino]hexanoic acid
-
-
(S)-2,6-bis[(2,3-dihydroxybenzoyl)amino]hexanoic acid methyl ester
-
-
(S)-2,6-bis[(2,3-dimethoxybenzoyl)amino]hexanoic acid methyl ester
-
-
(S)-2,7-bis[(2,3-dihydroxybenzoyl)amino]heptanoic acid methyl ester
-
-
(S)-2-acetyl-6-[(2,3-dihydroxybenzoyl)amino]hexanoic acid methyl ester
-
-
(S)-2-benzoylamino-6-[(2,3-dihydroxybenzoyl)amino]-hexanoamide
-
-
(S)-2-benzoylamino-6-[(2,3-dihydroxybenzoyl)amino]-hexanoic acid methyl ester
-
-
(S)-6-benzoylamino-2-[(2,3-dihydroxybenzoyl)amino]-hexanoic acid methyl ester
-
-
1,5-bis[(2,3-dihydroxybenzoyl)amino]pentane
-
-
BB-94
-
broad-spectrum MMP inhibitor
CGS 27023A
-
-
cyclic CTTHWGFTLC
-
a specific gelatinase inhibitor
doxycyclin
-
doxycycline significantly inhibits MMP-9 activity in gel zymography and also suppressed in situ gelatinase activity
doxycycline
EDTA
-
complete inhibition at 10 mM
GM6001
-
MMP-9-specific inhibitor
Melatonin
-
i.e. N-acetyl-5-methoxytryptamine, used in protection during gastric ulcer, arresting cell injury, protein carbonyl formation, and lipid peroxidation in mice during gastroprotection, inhibits MMP-9 expression and activity
minocycline
-
0.02 mM minocycline displays inhibitory action on MMP-9 expression and activity
MMP-9 inhibitor I
N,N'-[(2S)-6-[[(2,3-dihydroxyphenyl)carbonyl]amino]hexane-1,2-diyl]bis(2,3-dihydroxybenzamide)
-
-
N-[(5R)-5-[[(2,3-dihydroxyphenyl)carbonyl]amino]-6-hydroxyhexyl]-2,3-dihydroxybenzamide
-
-
N-[(5S)-5-[[(2,3-dihydroxyphenyl)carbonyl]amino]-6-hydroxyhexyl]-2,3-dihydroxybenzamide
-
-
N-[(5S)-6-amino-5-[[(2,3-dihydroxyphenyl)carbonyl]amino]hexyl]-2,3-dihydroxybenzamide
-
-
Phenanthroline
-
-
pioglitazone
-
pioglitazone reduces the upregulation of active form of MMP-9 after ischemia
SB-3CT
-
MMP-9-specific inhibitor
TIMP-1
-
i.e. tissue inhibitor of metalloproteinase 1, a natural inhibitor
-
tissue inhibitor of metalloproteinases-1
-
i.e. TIMP-1, plays a crucial role in the pathogenesis of hepatic fibrosis and thus may represent an important therapeutic target in the design of anti-fibrotic strategiesfor chronic liver disease, overview, molecular modeling of the three-dimensional structure of the MMP-9/TIMP-1 complex, overview
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
matrix metalloproteinase-7
MMP-9 is activated by matrix metalloproteinase-7
-
4-aminophenylmercuric acetate
acrolein
-
activates MMP-9 via EGFR/MAPK signaling and stimulation of pro-MMP-9 cleavage
cathepsin G
-
MMP9 is released in an inactive form and requires proteolytic activation, cathepsin G mediates activation of pro-matrix metalloproteinase 9
-
homocysteine
-
homocysteine activates matrix metalloproteinase-9, muscimol ameliorates the homocysteine-mediated MMP-9 activation
phorbol 12-myristate 13-acetate
-
30 nM 12-phorbol 13-myristate acetate is used to activate MMP-9, aqueous extract isolated from Prunella vulgaris reduces 12-phorbol 13-myristate acetate-induced activation of MMP-9
platelet-activating factor
-
i.e. 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, induces MMP-9 enzyme expression, and increases enzyme content and activity
tumor necrosis factor-alpha
-
-
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.8
SGFGSRYLTA
-
pH 7.5, 37°C, peptide A19
3.7
SGKGPRQITA
-
pH 7.5, 37°C, peptide C15
1.4
SGKIPRRLTA
-
pH 7.5, 37°C, peptide A11m1
4.7
SGKIPRTATA
-
pH 7.5, 37°C, peptide A11m2
1.3
SGKIPRTLTA
-
pH 7.5, 37°C, peptide A11
2.4
SGLKALMITA
-
pH 7.5, 37°C, peptide A7
13.5
SGLRPAKSTA
-
pH 7.5, 37°C, peptide A18
0.5
SGPLFYSVTA
-
pH 7.5, 37°C, peptide A10
2.9
SGPRAVSTTA
-
pH 7.5, 37°C, peptide A6
1
SGQPHYLTTA
-
pH 7.5, 37°C, peptide B1
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
11
SGFGSRYLTA
-
pH 7.5, 37°C, peptide A19
703
SGKGPRQITA
-
pH 7.5, 37°C, peptide C15
224
SGKIPRRLTA
-
pH 7.5, 37°C, peptide A11m1
9.4
SGKIPRTATA
-
pH 7.5, 37°C, peptide A11m2
86.4
SGKIPRTLTA
-
pH 7.5, 37°C, peptide A11
30
SGLKALMITA
-
pH 7.5, 37°C, peptide A7
78
SGLRPAKSTA
-
pH 7.5, 37°C, peptide A18
20
SGPLFYSVTA
-
pH 7.5, 37°C, peptide A10
178
SGPRAVSTTA
-
pH 7.5, 37°C, peptide A6
9
SGQPHYLTTA
-
pH 7.5, 37°C, peptide B1
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000005
(R)-2-(N-((6-fluoropyridin-3-yl)methyl)-4-methoxyphenyl-sulfonamido)-N-hydroxy-3-methylbutanamide
Mus musculus
-
-
0.000006
CGS 27023A
Mus musculus
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
-
assay at
7.5
-
assay at
8
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
fibroblast
Manually annotated by BRENDA team
method development and evaluation for immunostaining MMP-9 in mouse lung paraffin-embedded tissue utilizing human ovary as a control, overview. MMP-9 localization in lung tissue of a murine model of allergic asthma induced by chicken ovalbumin. The murine model of allergic asthma consists of a tissue inhibitor of metalloproteinase (TIMP)-1 genetic knockout backcrossed over 10 generations from 129/sv mice on a C57Bl/6 background
Manually annotated by BRENDA team
MMP9 is expressed in teeth from early embryonic to adult stage
Manually annotated by BRENDA team
-
a macrophage cell line established by immortalization of bone marrow macrophages from C57BL/6 mice with J2 recombinant retrovirus-expressing v-myc/v-raf oncogenes
Manually annotated by BRENDA team
-
in the walls
Manually annotated by BRENDA team
-
bone marrow-derived cells are the major source of MMP-9 in the ischemic brain
Manually annotated by BRENDA team
-
coronary arteritis is induced by Lactobacillus casei cell wall extract injection
Manually annotated by BRENDA team
-
MMP-9 protein is localized at the leading-edge keratinocytes in front of the migrating epidermal layer
Manually annotated by BRENDA team
-
induced by ethanol
Manually annotated by BRENDA team
-
unstimulated/resident and inflammatory, peritoneal leukocytes, constitutive expression
Manually annotated by BRENDA team
-
secretion of MMP-9
Manually annotated by BRENDA team
-
in zymosan-treated mice inducing peritonitis, MMP-9 and ZIMP-1 are located in the peritoneal fluid and plasma at the time of peritoneal neutrophil infiltration and persist there until time of monocyte/macrophage influx
Manually annotated by BRENDA team
-
in zymosan-treated mice inducing peritonitis, MMP-9 and ZIMP-1 are located in the peritoneal fluid and plasma at the time of peritoneal neutrophil infiltration and persist there until time of monocyte/macrophage influx
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
malfunction
metabolism
-
auto-amplified NFATc1 plays a key role in upregulating expressions of genes required for osteoclastmaturation, such as TRAP, cathepsin K, or MMP-9,which are requisite for the bone resorption processes mediated by mature osteoclasts
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MMP9_MOUSE
730
0
80535
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
-
SDS-PAGE
103000
-
x * 103000, about, pro-MMP9, SDS-PAGE, x * 86000, about, activated MMP-9, SDS-PAGE
104000
-
gel filtration
105000
-
the molecular mass of recombinant MMP-9 is approximately 105000 Da, SDS-PAGE
82000
-
1 * 92000, pro-enzyme, SDS-PAGE, 1 * 82000, recombinant truncated mutant MMP-9, SDS-PAGE
86000
-
x * 103000, about, pro-MMP9, SDS-PAGE, x * 86000, about, activated MMP-9, SDS-PAGE
88000
-
active form of MMP-9, SDS-PAGE
92000
96000
-
proMMP-9, SDS-PAGE
97000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 103000, about, pro-MMP9, SDS-PAGE, x * 86000, about, activated MMP-9, SDS-PAGE
dimer
-
2 * 60000-65000, extracellular proteolytically active disulfide-linked MMP-9 dimers, SDS-PAGE
monomer
-
1 * 92000, pro-enzyme, SDS-PAGE, 1 * 82000, recombinant truncated mutant MMP-9, SDS-PAGE
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
proteolytic modification
-
acrolein stimulates pro-MMP-9 cleavage and activation
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E402H/H411E
-
site-directed mutagenesis, proteolytic inactive MMP-9 mutant, application of the MMP-9 mutant decreases portal and periportal accumulation of collagen and inhibits fibrogenesis induced by CCl4 in mice
E402Q
-
site-directed mutagenesis, proteolytic inactive MMP-9 mutant, application of the MMP-9 mutant decreases portal and periportal accumulation of collagen and inhibits fibrogenesis induced by CCl4 in mice, the MMP-9 mutant suppresses transdifferentiation of hepatic stellate cells to the myofibroblast-like phenotype in vitro and in vivo. Adenoviral application of the mutant leads to increased apoptosis of activated hepatic stellate cells
H401A
-
site-directed mutagenesis, proteolytic inactive MMP-9 mutant, application of the MMP-9 mutant decreases portal and periportal accumulation of collagen and inhibits fibrogenesis induced by CCl4 in mice, the MMP-9 mutant suppresses transdifferentiation of hepatic stellate cells to the myofibroblast-like phenotype in vitro and in vivo. Adenoviral application of the mutant leads to increased apoptosis of activated hepatic stellate cells
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
native MMP-9 from gastric mucosa
-
recombinant activated MMP-9 dimers by gelatin affnity chromatography
-
recombinant enzyme
-
recombinant secreted mutant enzymes from Hep-G2 cells by gelatin affinity chromatography to homogeneity
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene MMP9, quantitative real-time PCR enzyme expression analysis
cDNA encoding the catalytic domain cloned into pCDNA3 and used to transfect HEK 293 cells
-
expressed in A549-C and A549-FI cells
-
expression of mutant enzymes in Hep-G2 cells using recombinant adenoviral vectors adenovirus-2 or adenovirus-5, secretion of the recombinant enzymes, overview
-
expression of wild-type full-length MMP-9 and of a mutant version lacking the O-glycosylated linker region and hemopexin domains in Drosophila melanogaster S2 cells using the Drosophila metallothionein promoter, the native MMP-9 signal peptide is utilized for secretion contained in the beginning of the sequences
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
MMP-9 secretion is CnA-isoform specific, i.e. the CnAbeta isoform contributes to the CsA-induced upregulation of MMP-9 while the CnAalpha does not
the levels of MMP-9 are increased in the brain and in the peripheral organs after induction of experimental autoimmune encephalomyelitis. After 40 days all the animals recover and do not show signs of experimental autoimmune encephalomyelitis. The absence of MMP-9 in the remission phase suggests a protective role of MMP-9 in the late phase of the disease, because single mmp-9-/- mice present a delayed remission in comparison with wild-type animals suggesting a phase-dependent role of MMP-9 in the disease. MMP-9 levels remain increased in the brains and, to a higher extend, in the spleens of the wild-type mice even during the remission phase, which is in line with the role of MMP-9 as a useful marker and a protective factor for experimental autoimmune encephalomyelitis in the remission phase
50 mg/kg (-)-epigallocatechin gallate administration significantly inhibits the induction of the active form of MMP-9
-
acrolein exposure induces MMP-9 expression at both protein and mRNA levels in the lung tissue
-
activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9. Red wine extrac and quercetin inhibit significantly the tumor necrosis factor-alpha-induced upregulation of MMP-9 whereas resveratrol does not have significant inhibitory effects
-
aqueous extract isolated from Prunella vulgaris suppresses 12-phorbol 13-myristate acetate-enhanced expression of MMP-9 protein, mRNA and transcription activity levels through suppression of nuclear factor-kappaB activation
-
auto-amplified NFATc1 plays a key role in upregulating MMP-9
-
Borrelia burgdorferi induces the host protease, matrix metalloproteinase 9, the induction of MMP-9 may allow the organism to disseminate and produce local tissue destruction
-
ethanol extracts of Ocimum sanctum suppresses MMP-9 enzymatic activity in Lewis lung carcinoma cells in a dose-dependent manner (0.025-0.2 mg/ml)
-
in vivo administration of a nuclear factor-kappa B inhibitory peptide blocks the expression of MMP-9 in dystrophic muscle of mdx mice
-
mild nonischemic cerebral venous hypertension results in increased MMP-9 activity. MMP-9 activity increases 10fold 1 day after surgery, gradually decreases afterwards, and returns to baseline 2 weeks after surgery
-
MMP-9 expression and activity significantly increase on day 3 after status epilepticus after pilocarpine injection
-
MMP-9 is upregulated during inflammatory bowel disease, MMP-9 activity is highly upregulated in wild type mice treated with dextran sodium sulfate, Salmonella typhimurium, or trinitrobenzene sulfonic acid
-
MMP-9 mRNA expression and release is significantly decreased after treatment with 0.0125-0.05 mg/ml aspirin for 24 h. The aspirin-induced down-regulation of MMP-9 mRNA expression and reduction of MMP-9 release are notably alleviated after pretreatment with specific inhibitors of peroxisome proliferator-activated receptor alpha/gamma
-
MMP-9 mRNA expression is induced by interleukin 17, at 200 ng/ml the mRNA level increases about 17times compared with the untreated group
-
myricetin, i.e. 3,3',4',5,5',7-hexahydroxyflavone, suppresses UVB-induced MMP-9 expression through the suppression of Raf kinase activity
-
peroxisome proliferators-activated receptor gamma antagonist GW9662 has little effect on MMP-9 expression
-
resveratrol (i.e. trans-3,4',5-trihydroxystilbene) inhibits MMP-9 mRNA and protein expression in a concentration-dependent manner (0.0025-0.01 mM) by up-regulating peroxisome proliferators-activated receptor alpha expression, The effect of resveratrol on MMp-9 can be offset partially by MK886
-
significant increases of MMP9 activity and protein expression are detected in B19-VP1u IgG group, phosphatidylinositol 3-phosphate kinase and phosphorylated extracellular signal-regulated kinase proteins are involved in the induction of MMP9
-
superparamagnetic iron oxide nanoparticle-mmp9 retention in global cerebral ischemia animals shows that striatal mmp-9 mRNA expression is 2fold greater than that of the control group and the elevation in cortical mmp-9 mRNA is less than 2fold in live brains, global cerebral ischemia in mice induces MMP-9 activity in regions with hyperintense diffusion-weighted imaging
the gelatinolytic activity of MMP-9 is constitutively activated in Lewis lung carcinoma cells
-
the inability of iNOS-deficient mice to generate iNOS-derived nitric oxide profoundly inhibits MMP-9 activity in livers after ischemia/reperfusion injury, exposure of isolated murine neutrophils and macrophages to exogenous nitric oxide increases MMP-9 activity in both cell types, nitric oxide may activate MMP-9 in leukocytes by either autocrine or paracrine mechanisms
-
the intracerebroventricular injection of amyloid beta25-35, amyloid beta1-40, and amyloid beta1-42, but not amyloid beta40-1, transiently increases MMP-9 activity and protein expression in the hippocampus, the expression of MMP-9 is increased in both neurons and glial cells in the hippocampus after amyloid beta treatment
-
the mRNA levels of MMP-9 are significantly higher in diaphragm muscle from 3-, 6- and 8-week-old mdx mice compared with age-matched C57BL/10 control mice
-
there is an increase in the active form of MMP-9 after ischemia
-
total Panax notoginsenosides downregulate expression of MMP-9 apolipoprotein E-knockout mice
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
-
MMP-9 is an attractive target for therapeutic intervention studies in mouse models
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kridel, S.J.; Chen, E.; Kotra, L.P.; Howard, E.W.; Mobashery, S.; Smith, J.W.
Substrate hydrolysis by matrix metalloproteinase-9
J. Biol. Chem.
276
20572-20578
2001
Mus musculus
Manually annotated by BRENDA team
Deshmukh, H.S.; Shaver, C.; Case, L.M.; Dietsch, M.; Wesselkamper, S.C.; Hardie, W.D.; Korfhagen, T.R.; Corradi, M.; Nadel, J.A.; Borchers, M.T.; Leikauf, G.D.
Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production
Am. J. Respir. Cell Mol. Biol.
38
446-454
2008
Mus musculus
Manually annotated by BRENDA team
Lau, A.C.; Duong, T.T.; Ito, S.; Yeung, R.S.
Matrix metalloproteinase 9 activity leads to elastin breakdown in an animal model of Kawasaki disease
Arthritis Rheum.
58
854-863
2008
Mus musculus
Manually annotated by BRENDA team
Roderfeld, M.; Weiskirchen, R.; Wagner, S.; Berres, M.L.; Henkel, C.; Groetzinger, J.; Gressner, A.M.; Matern, S.; Roeb, E.
Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice
FASEB J.
20
444-454
2006
Mus musculus, Mus musculus BALB/c
Manually annotated by BRENDA team
Bergin, P.J.; Raghavan, S.; Svensson, H.; Starckx, S.; Van Aelst, I.; Gjertsson, I.; Opdenakker, G.; Quiding-Jaerbrink, M.
Gastric gelatinase B/matrix metalloproteinase-9 is rapidly increased in Helicobacter felis-induced gastritis
FEMS Immunol. Med. Microbiol.
52
88-98
2008
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Kolaczkowska, E.; Chadzinska, M.; Scislowska-Czarnecka, A.; Plytycz, B.; Opdenakker, G.; Arnold, B.
Gelatinase B/matrix metalloproteinase-9 contributes to cellular infiltration in a murine model of zymosan peritonitis
Immunobiology
211
137-148
2006
Mus musculus, Mus musculus BALB/c
Manually annotated by BRENDA team
Kolaczkowska, E.; Arnold, B.; Opdenakker, G.
Gelatinase B/MMP-9 as an inflammatory marker enzyme in mouse zymosan peritonitis: comparison of phase-specific and cell-specific production by mast cells, macrophages and neutrophils
Immunobiology
213
109-124
2008
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Ko, H.M.; Kang, J.H.; Jung, B.; Kim, H.A.; Park, S.J.; Kim, K.J.; Kang, Y.R.; Lee, H.K.; Im, S.Y.
Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis
Int. J. Cancer
120
1277-1283
2007
Mus musculus
Manually annotated by BRENDA team
Malik, M.; Bakshi, C.S.; McCabe, K.; Catlett, S.V.; Shah, A.; Singh, R.; Jackson, P.L.; Gaggar, A.; Metzger, D.W.; Melendez, J.A.; Blalock, J.E.; Sellati, T.J.
Matrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensis
J. Immunol.
178
1013-1020
2007
Mus musculus, Mus musculus FVB/NJ
Manually annotated by BRENDA team
Swarnakar, S.; Mishra, A.; Ganguly, K.; Sharma, A.V.
Matrix metalloproteinase-9 activity and expression is reduced by melatonin during prevention of ethanol-induced gastric ulcer in mice
J. Pineal Res.
43
56-64
2007
Mus musculus, Mus musculus BALB/c
Manually annotated by BRENDA team
Ridnour, L.A.; Windhausen, A.N.; Isenberg, J.S.; Yeung, N.; Thomas, D.D.; Vitek, M.P.; Roberts, D.D.; Wink, D.A.
Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways
Proc. Natl. Acad. Sci. USA
104
16898-16903
2007
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Addabbo, F.; Ratliff, B.; Park, H.C.; Kuo, M.C.; Ungvari, Z.; Csiszar, A.; Ciszar, A.; Krasnikov, B.; Krasnikof, B.; Sodhi, K.; Zhang, F.; Nasjletti, A.; Goligorsky, M.S.
The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach
Am. J. Pathol.
174
34-43
2009
Mus musculus
Manually annotated by BRENDA team
Wagner, S.; Breyholz, H.J.; Hoeltke, C.; Faust, A.; Schober, O.; Schaefers, M.; Kopka, K.
A new 18F-labelled derivative of the MMP inhibitor CGS 27023A for PET: radiosynthesis and initial small-animal PET studies
Appl. Radiat. Isot.
67
606-610
2009
Mus musculus
Manually annotated by BRENDA team
Lee, S.R.; Kim, H.Y.; Hong, J.S.; Baek, W.K.; Park, J.W.
PPARgamma agonist pioglitazone reduces matrix metalloproteinase-9 activity and neuronal damage after focal cerebral ischemia
Biochem. Biophys. Res. Commun.
380
17-21
2009
Mus musculus
Manually annotated by BRENDA team
Miyanaga, S.; Sakurai, H.; Saiki, I.; Onaka, H.; Igarashi, Y.
Synthesis and evaluation of myxochelin analogues as antimetastatic agents
Bioorg. Med. Chem.
17
2724-2732
2009
Mus musculus
Manually annotated by BRENDA team
Buhler, L.A.; Samara, R.; Guzman, E.; Wilson, C.L.; Krizanac-Bengez, L.; Janigro, D.; Ethell, D.W.
Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis
BMC Neurosci.
10
17
2009
Mus musculus (P41245)
Manually annotated by BRENDA team
Shen, D.; Tang, Q.; Huang, Z.; Chen, Y.; Xiong, R.; Wu, H.; Huang, J.; Feng, S.; Yan, L.; Bian, Z.
The effects of NK4 on viral myocarditis mice
Cardiovasc. Pathol.
18
323-331
2009
Mus musculus
Manually annotated by BRENDA team
Dwivedi, A.; Slater, S.C.; George, S.J.
MMP-9 and -12 cause N-cadherin shedding and thereby beta-catenin signalling and vascular smooth muscle cell proliferation
Cardiovasc. Res.
81
178-186
2009
Mus musculus
Manually annotated by BRENDA team
Xiao, J.; Shimada, M.; Liu, W.; Hu, D.; Matsumori, A.
Anti-inflammatory effects of eplerenone on viral myocarditis
Eur. J. Heart Fail.
11
349-353
2009
Mus musculus
Manually annotated by BRENDA team
Jin, G.; Tsuji, K.; Xing, C.; Yang, Y.G.; Wang, X.; Lo, E.H.
CD47 gene knockout protects against transient focal cerebral ischemia in mice
Exp. Neurol.
217
165-170
2009
Mus musculus
Manually annotated by BRENDA team
Assi, K.; Mills, J.; Owen, D.; Ong, C.; St Arnaud, R.; Dedhar, S.; Salh, B.
Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis
Gut
57
931-940
2008
Mus musculus
Manually annotated by BRENDA team
Pareja-Santos, A.; Saraiva, T.C.; Costa, E.P.; Santos, M.F.; Zorn, T.T.; Souza, V.M.; Lopes-Ferreira, M.; Lima, C.
Delayed local inflammatory response induced by Thalassophryne nattereri venom is related to extracellular matrix degradation
Int. J. Exp. Pathol.
90
34-43
2009
Mus musculus
Manually annotated by BRENDA team
Adiseshaiah, P.; Vaz, M.; Machireddy, N.; Kalvakolanu, D.V.; Reddy, S.P.
A Fra-1-dependent, matrix metalloproteinase driven EGFR activation promotes human lung epithelial cell motility and invasion
J. Cell. Physiol.
216
405-412
2008
Mus musculus
Manually annotated by BRENDA team
Bilousova, T.V.; Dansie, L.; Ngo, M.; Aye, J.; Charles, J.R.; Ethell, D.W.; Ethell, I.M.
Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model
J. Med. Genet.
46
94-102
2009
Mus musculus
Manually annotated by BRENDA team
Dai, J.P.; Chen, J.; Bei, Y.F.; Han, B.X.; Wang, S.
Influence of borneol on primary mice oral fibroblasts: a penetration enhancer may be used in oral submucous fibrosis
J. Oral Pathol. Med.
38
276-281
2009
Mus musculus
Manually annotated by BRENDA team
Seeger, F.H.; Chen, L.; Spyridopoulos, I.; Altschmied, J.; Aicher, A.; Haendeler, J.
Downregulation of ETS rescues diabetes-induced reduction of endothelial progenitor cells
PLoS ONE
4
e4529
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Sander, A.L.; Henrich, D.; Muth, C.M.; Marzi, I.; Barker, J.H.; Frank, J.M.
In vivo effect of hyperbaric oxygen on wound angiogenesis and epithelialization
Wound Repair Regen.
17
179-184
2009
Mus musculus
Manually annotated by BRENDA team
Hamada, T.; Duarte, S.; Tsuchihashi, S.; Busuttil, R.W.; Coito, A.J.
Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury
Am. J. Pathol.
174
2265-2277
2009
Mus musculus
Manually annotated by BRENDA team
Garg, P.; Vijay-Kumar, M.; Wang, L.; Gewirtz, A.T.; Merlin, D.; Sitaraman, S.V.
Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis
Am. J. Physiol. Gastrointest. Liver Physiol.
296
G175-G184
2009
Mus musculus
Manually annotated by BRENDA team
Choi, M.S.; Cho, K.S.; Shin, S.M.; Ko, H.M.; Kwon, K.J.; Shin, C.Y.; Ko, K.H.
ATP induced microglial cell migration through non-transcriptional activation of matrix metalloproteinase-9
Arch. Pharm. Res.
33
257-265
2010
Mus musculus
Manually annotated by BRENDA team
Huang, P.H.; Chen, Y.H.; Wang, C.H.; Chen, J.S.; Tsai, H.Y.; Lin, F.Y.; Lo, W.Y.; Wu, T.C.; Sata, M.; Chen, J.W.; Lin, S.J.
Matrix metalloproteinase-9 is essential for ischemia-induced neovascularization by modulating bone marrow-derived endothelial progenitor cells
Arterioscler. Thromb. Vasc. Biol.
29
1179-1184
2009
Mus musculus
Manually annotated by BRENDA team
Jung, S.K.; Lee, K.W.; Kim, H.Y.; Oh, M.H.; Byun, S.; Lim, S.H.; Heo, Y.S.; Kang, N.J.; Bode, A.M.; Dong, Z.; Lee, H.J.
Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf
Biochem. Pharmacol.
79
1455-1461
2010
Mus musculus
Manually annotated by BRENDA team
Wang, G.; Guo, Q.; Hossain, M.; Fazio, V.; Zeynalov, E.; Janigro, D.; Mayberg, M.R.; Namura, S.
Bone marrow-derived cells are the major source of MMP-9 contributing to blood-brain barrier dysfunction and infarct formation after ischemic stroke in mice
Brain Res.
1294
183-192
2009
Mus musculus
Manually annotated by BRENDA team
Mishra, P.K.; Metreveli, N.; Tyagi, S.C.
MMP-9 gene ablation and TIMP-4 mitigate PAR-1-mediated cardiomyocyte dysfunction: a plausible role of dicer and miRNA
Cell Biochem. Biophys.
57
67-76
2010
Mus musculus
Manually annotated by BRENDA team
Lau, A.C.; Duong, T.T.; Ito, S.; Wilson, G.J.; Yeung, R.S.
Inhibition of matrix metalloproteinase-9 activity improves coronary outcome in an animal model of Kawasaki disease
Clin. Exp. Immunol.
157
300-309
2009
Mus musculus
Manually annotated by BRENDA team
Kim, S.C.; Magesh, V.; Jeong, S.J.; Lee, H.J.; Ahn, K.S.; Lee, H.J.; Lee, E.O.; Kim, S.H.; Lee, M.H.; Kim, J.H.; Kim, S.H.
Ethanol extract of Ocimum sanctum exerts anti-metastatic activity through inactivation of matrix metalloproteinase-9 and enhancement of anti-oxidant enzymes
Food Chem. Toxicol.
48
1478-1482
2010
Mus musculus
Manually annotated by BRENDA team
Choi, J.H.; Han, E.H.; Hwang, Y.P.; Choi, J.M.; Choi, C.Y.; Chung, Y.C.; Seo, J.K.; Jeong, H.G.
Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-kappaB-dependent MMP-9 expression
Food Chem. Toxicol.
48
564-571
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Li, H.; Mittal, A.; Makonchuk, D.Y.; Bhatnagar, S.; Kumar, A.
Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy
Hum. Mol. Genet.
18
2584-2598
2009
Mus musculus
Manually annotated by BRENDA team
Qiu, Z.; Dillen, C.; Hu, J.; Verbeke, H.; Struyf, S.; Van Damme, J.; Opdenakker, G.
Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes
Immunobiology
214
835-842
2009
Mus musculus
Manually annotated by BRENDA team
Kolaczkowska, E.; Koziol, A.; Plytycz, B.; Arnold, B.; Opdenakker, G.
Altered apoptosis of inflammatory neutrophils in MMP-9-deficient mice is due to lower expression and activity of caspase-3
Immunol. Lett.
126
73-82
2009
Mus musculus
Manually annotated by BRENDA team
Heilpern, A.J.; Wertheim, W.; He, J.; Perides, G.; Bronson, R.T.; Hu, L.T.
Matrix metalloproteinase 9 plays a key role in lyme arthritis but not in dissemination of Borrelia burgdorferi
Infect. Immun.
77
2643-2649
2009
Mus musculus
Manually annotated by BRENDA team
Yiqin, Y.; Meilin, X.; Jie, X.; Keping, Z.
Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARalpha/gamma and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages
Inflammation
32
233-241
2009
Mus musculus
Manually annotated by BRENDA team
Liu, D.S.; Wang, T.; Han, S.X.; Dong, J.J.; Liao, Z.L.; He, G.M.; Chen, L.; Chen, Y.J.; Xu, D.; Hou, Y.; Li, Y.P.; Wen, F.Q.
p38 MAPK and MMP-9 cooperatively regulate mucus overproduction in mice exposed to acrolein fog
Int. Immunopharmacol.
9
1228-1235
2009
Mus musculus
Manually annotated by BRENDA team
Hwang, M.K.; Song, N.R.; Kang, N.J.; Lee, K.W.; Lee, H.J.
Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin
Int. J. Biochem. Cell Biol.
41
1592-1600
2009
Mus musculus
Manually annotated by BRENDA team
Tsai, C.C.; Tzang, B.S.; Chiang, S.Y.; Hsu, G.J.; Hsu, T.C.
Increased expression of Matrix Metalloproteinase 9 in liver from NZB/W F1 mice received antibody against human parvovirus B19 VP1 unique region protein
J. Biomed. Sci.
16
14
2009
Mus musculus
Manually annotated by BRENDA team
Tyagi, N.; Gillespie, W.; Vacek, J.C.; Sen, U.; Tyagi, S.C.; Lominadze, D.
Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway
J. Cell. Physiol.
220
257-266
2009
Mus musculus
Manually annotated by BRENDA team
Gao, P.; Zhu, Y.; Ling, F.; Shen, F.; Lee, B.; Gabriel, R.A.; Hao, Q.; Yang, G.Y.; Su, H.; Young, W.L.
Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9
J. Cereb. Blood Flow Metab.
29
1482-1490
2009
Mus musculus
Manually annotated by BRENDA team
Liu, G.; Wang, B.; Zhang, J.; Jiang, H.; Liu, F.
Total panax notoginsenosides prevent atherosclerosis in apolipoprotein E-knockout mice: Role of downregulation of CD40 and MMP-9 expression
J. Ethnopharmacol.
126
350-354
2009
Mus musculus
Manually annotated by BRENDA team
De Paiva, C.S.; Yoon, K.C.; Pangelinan, S.B.; Pham, S.; Puthenparambil, L.M.; Chuang, E.Y.; Farley, W.J.; Stern, M.E.; Li, D.Q.; Pflugfelder, S.C.
Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9
J. Inflamm.
6
31
2009
Mus musculus
Manually annotated by BRENDA team
Liu, C.H.; You, Z.; Liu, C.M.; Kim, Y.R.; Whalen, M.J.; Rosen, B.R.; Liu, P.K.
Diffusion-weighted magnetic resonance imaging reversal by gene knockdown of matrix metalloproteinase-9 activities in live animal brains
J. Neurosci.
29
3508-3517
2009
Mus musculus (Q2M4J5)
Manually annotated by BRENDA team
Park, J.W.; Hong, J.S.; Lee, K.S.; Kim, H.Y.; Lee, J.J.; Lee, S.R.
Green tea polyphenol (-)-epigallocatechin gallate reduces matrix metalloproteinase-9 activity following transient focal cerebral ischemia
J. Nutr. Biochem.
21
1038-1044
2009
Mus musculus
Manually annotated by BRENDA team
Mizoguchi, H.; Takuma, K.; Fukuzaki, E.; Ibi, D.; Someya, E.; Akazawa, K.H.; Alkam, T.; Tsunekawa, H.; Mouri, A.; Noda, Y.; Nabeshima, T.; Yamada, K.
Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice
J. Pharmacol. Exp. Ther.
331
14-22
2009
Mus musculus
Manually annotated by BRENDA team
Thomas, A.C.; Newby, A.C.
Effect of matrix metalloproteinase-9 knockout on vein graft remodelling in mice
J. Vasc. Res.
47
299-308
2009
Mus musculus
Manually annotated by BRENDA team
Tian, W.; Kyriakides, T.R.
Matrix metalloproteinase-9 deficiency leads to prolonged foreign body response in the brain associated with increased IL-1beta levels and leakage of the blood-brain barrier
Matrix Biol.
28
148-159
2009
Mus musculus
Manually annotated by BRENDA team
Kyriakides, T.R.; Wulsin, D.; Skokos, E.A.; Fleckman, P.; Pirrone, A.; Shipley, J.M.; Senior, R.M.; Bornstein, P.
Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis
Matrix Biol.
28
65-73
2009
Mus musculus
Manually annotated by BRENDA team
Wilson, T.J.; Nannuru, K.C.; Singh, R.K.
Cathepsin G-mediated activation of pro-matrix metalloproteinase 9 at the tumor-bone interface promotes transforming growth factor-beta signaling and bone destruction
Mol. Cancer Res.
7
1224-1233
2009
Mus musculus
Manually annotated by BRENDA team
Vaisar, T.; Kassim, S.Y.; Gomez, I.G.; Green, P.S.; Hargarten, S.; Gough, P.J.; Parks, W.C.; Wilson, C.L.; Raines, E.W.; Heinecke, J.W.
MMP-9 sheds the beta2 integrin subunit (CD18) from macrophages
Mol. Cell. Proteomics
8
1044-1060
2009
Mus musculus
Manually annotated by BRENDA team
Lee, H.; Park, J.W.; Kim, S.P.; Lo, E.H.; Lee, S.R.
Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia
Neurobiol. Dis.
34
189-198
2009
Mus musculus
Manually annotated by BRENDA team
Kim, G.W.; Kim, H.J.; Cho, K.J.; Kim, H.W.; Cho, Y.J.; Lee, B.I.
The role of MMP-9 in integrin-mediated hippocampal cell death after pilocarpine-induced status epilepticus
Neurobiol. Dis.
36
169-180
2009
Mus musculus
Manually annotated by BRENDA team
Cheng, G.; Zhang, X.; Gao, D.; Jiang, X.; Dong, W.
Resveratrol inhibits MMP-9 expression by up-regulating PPAR alpha expression in an oxygen glucose deprivation-exposed neuron model
Neurosci. Lett.
451
105-108
2009
Mus musculus
Manually annotated by BRENDA team
Franco, G.C.; Kajiya, M.; Nakanishi, T.; Ohta, K.; Rosalen, P.L.; Groppo, F.C.; Ernst, C.W.; Boyesen, J.L.; Bartlett, J.D.; Stashenko, P.; Taubman, M.A.; Kawai, T.
Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo
Exp. Cell Res.
317
1454-1464
2011
Mus musculus, Mus musculus BALB/c
Manually annotated by BRENDA team
Awla, D.; Abdulla, A.; Syk, I.; Jeppsson, B.; Regner, S.; Thorlacius, H.
Neutrophil-derived matrix metalloproteinase-9 is a potent activator of trypsinogen in acinar cells in acute pancreatitis
J. Leukoc. Biol.
91
711-719
2011
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Rasch, M.G.; Lund, I.K.; Illemann, M.; H?yer-Hansen, G.; Gardsvoll, H.
Purification and characterization of recombinant full-length and protease domain of murine MMP-9 expressed in Drosophila S2 cells
Protein Expr. Purif.
72
87-94
2010
Mus musculus
Manually annotated by BRENDA team
Sands, M.F.
Localization of matrix metalloproteinase (MMP)-9 in lung tissue of a murine model of allergic asthma
Immunol. Invest.
41
87-96
2012
Mus musculus (P41245), Mus musculus, Mus musculus C57BL/6 (P41245)
Manually annotated by BRENDA team
Aston-Mourney, K.; Zraika, S.; Udayasankar, J.; Subramanian, S.; Green, P.; Kahn, S.; Hull, R.
Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide
J. Biol. Chem.
288
3553-3559
2013
Homo sapiens (P14780), Homo sapiens, Mus musculus (P41245), Mus musculus, Mus musculus C57BL/6 x DBA/2 (P41245)
Manually annotated by BRENDA team
Francis, C.E.; Bai, Y.
Differential expression of cyclosporine A-Induced calcineurin isoform-specific matrix metalloproteinase 9 (MMP-9) in renal fibroblasts
Biochem. Biophys. Res. Commun.
503
2549-2554
2018
Mus musculus (P41245)
Manually annotated by BRENDA team
Ugarte-Berzal, E.; Berghmans, N.; Boon, L.; Martens, E.; Vandooren, J.; Cauwe, B.; Thijs, G.; Proost, P.; Van Damme, J.; Opdenakker, G.
Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis
PLoS ONE
13
e0197944
2018
Mus musculus (P41245)
Manually annotated by BRENDA team
Yuan, G.; Chen, L.; Feng, J.; Yang, G.; Ni, Q.; Xu, X.; Wan, C.; Lindsey, M.; Donly, K.J.; MacDougall, M.; Chen, Z.; Chen, S.
Dentin sialoprotein is a novel substrate of matrix metalloproteinase 9 in vitro and in vivo
Sci. Rep.
7
42449
2017
Mus musculus (P41245), Mus musculus
Manually annotated by BRENDA team