Reference on EC 3.4.24.27 - thermolysin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Morihara, K.; Tsuzuki, H.
Comparative study of various neutral proteinases from microorganisms: specificity with oligopeptides
Arch. Biochem. Biophys.
146
291-296
1971
Aspergillus oryzae, Bacillus thermoproteolyticus
Ohta, Y.; Ogura, Y.; Wada, A.
Thermostable protease from thermophilic bacteria. I. Thermostability, physiocochemical properties, and amino acid composition
J. Biol. Chem.
241
5919-5925
1966
Bacillus thermoproteolyticus
Desmazeaud, M.J.; Hermier, J.H.
Specificity of the nuclear protease produced by Micrococcus caseolyticus
Eur. J. Biochem.
19
51-55
1971
Macrococcus caseolyticus
Nurul Alam, M.; Tadasa, K.; Kayahara, H.
Kinetic behavior of activation of thermolysin by normal alcohols
Biotechnol. Lett.
18
45-50
1996
Bacillus thermoproteolyticus
-
Inagaki, T.; Tadasa, K.; Kayahara, H.
Modification effects of organic solvents on microenvironment of the enzyme in thermolysin-catalyzed peptide synthesis of N-(benzyloxycarbonyl)-L-phenylalanyl-L-phenylalanine methyl ester
Biosci. Biotechnol. Biochem.
58
1439-1442
1994
Bacillus thermoproteolyticus
-
Marcotte, P.A.; Henkin, J.
Characterization of the activation of pro-urokinase by thermolysin
Biochim. Biophys. Acta
1161
105-112
1993
Bacillus thermoproteolyticus
Zamai, M.; Fassina, G.
Mobile phase effects in the high-performance affinity purification of thermolysin
J. Chromatogr.
549
195-205
1991
Bacillus thermoproteolyticus
-
Yang, J.J.; van Wart, H.E.
Kinetics of hydrolysis of dansyl peptide substrates by thermolysin: analysis of fluorescence changes and determination of steady-state kinetic parameters
Biochemistry
33
6508-6515
1994
Bacillus thermoproteolyticus
Gettins, P.
Thermolysin-inhibitor complexes examined by 31P and 113Cd NMR spectroscopy
J. Biol. Chem.
263
10208-10211
1988
Bacillus thermoproteolyticus
Grobelny, D.; Poncz, L.; Galardy, R.E.
Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids
Biochemistry
31
7152-7154
1992
Bacillus thermoproteolyticus
Christianson, D.W.; Lipscomb, W.N.
Comparison of carboxypeptidase A and thermolysin: inhibition by phosphonamidates
J. Am. Chem. Soc.
110
5560-5565
1988
Bacillus thermoproteolyticus
-
Kitagishi, K.; Hiromi, K.
Binding between thermolysin and its specific inhibitor, N-phosphoryl-L-leucyl-L-tryptophan (PLT)
J. Biochem.
99
191-197
1986
Bacillus thermoproteolyticus
Kitagishi, K.; Hiromi, K.
Binding between thermolysin and its specific inhibitor, phosphoramidon
J. Biochem.
95
529-534
1984
Bacillus thermoproteolyticus
Maycock, A.L.; DeSousa, D.M.; Payne, L.G.; ten Broeke, J.; Wu, M.T.; Patchett, A.A.
Inhibition of thermolysin by N-carboxymethyl dipeptides
Biochem. Biophys. Res. Commun.
102
963-969
1981
Bacillus thermoproteolyticus
Gray, R.D.; Pierce, W.M.; Harrod, J.W.; Rademacher, J.M.
Inhibition of thermolysin by bifunctional N-carboxyalkyl dipeptides
Arch. Biochem. Biophys.
256
692-698
1987
Bacillus thermoproteolyticus
Durrant, I.; Beynon, R.J.; Rodgers, P.B.
The effect of inhibitors on thermolysin-catalyzed peptide bond synthesis
Biochem. Soc. Trans.
14
143
1986
Bacillus thermoproteolyticus
-
Nakanishi, K.; Kimura, Y.; Matsuno, R.
Kinetics and equilibrium of enzymatic synthesis of peptides in aqueous/organic biphasic systems. Thermolysin-catalyzed synthesis of N-(benzyloxycarbonyl)-L-aspartyl-L-phenylalanine methyl ester [published erratum appears in Eur J Biochem 1987 Sep 15;167(3):601]
Eur. J. Biochem.
161
541-549
1986
Bacillus thermoproteolyticus
Feder, J.; Brougham, L.R.; Wildi, B.S.
Inhibition of thermolysin by dipeptides
Biochemistry
13
1186-1189
1974
Bacillus thermoproteolyticus
Titani, K.; Hermodson, M.A.; Ericsson, L.H.; Walsh, K.A.; Neurath, H.
Amino acid sequence of thermolysin. Isolation and characterization of the fragments obtained by cleavage with cyanogen bromide
Biochemistry
11
2427-2435
1972
Bacillus thermoproteolyticus
Nishino, N.; Powers, J.C.
Peptide hydroxamic acids as inhibitors of thermolysin
Biochemistry
17
2846-2850
1978
Bacillus thermoproteolyticus
Morgan, G.; Fruton, J.S.
Kinetics of the action of thermolysin on peptide substrates
Biochemistry
17
3562-3568
1978
Bacillus thermoproteolyticus
Rasnick, D.; Powers, J.C.
Active site directed irreversible inhibition of thermolysin
Biochemistry
17
4363-4369
1978
Bacillus thermoproteolyticus
Kam, C.M.; Nishino, N.; Powers, J.C.
Inhibition of thermolysin and carboxypeptidase A by phosphoramidates
Biochemistry
18
3032-3038
1979
Bacillus thermoproteolyticus
Nishino, N.; Powers, J.C.
Design of potent reversible inhibitors for thermolysin. Peptides containing zinc coordinating ligands and their use in affinity chromatography
Biochemistry
18
4340-4347
1979
Bacillus thermoproteolyticus
Holmes, M.A.; Matthews, B.W.
Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis
Biochemistry
20
6912-6920
1981
Bacillus thermoproteolyticus
Weaver, L.H.; Lester, W.R.; Matthews, B.W.
A crystallographic study of the complex of phosphoramidon with thermolysin. A model for the presumed catalytic transition state and for the binding of extended substances
J. Mol. Biol.
114
119-132
1977
Bacillus thermoproteolyticus
Kester, W.R.; Matthews, B.W.
Crystallographic study of the binding of dipeptide inhibitors to thermolysin: implications for the mechanism of catalysis
Biochemistry
16
2506-2516
1977
Bacillus thermoproteolyticus
Tajima, M.; Urabe, I.; Yutani, K.; Okada, H.
Role of calcium ions in the thermostability of thermolysin and Bacillus subtilis var. amylosacchariticus neutral protease
Eur. J. Biochem.
64
243-247
1976
Bacillus thermoproteolyticus
Matthews, B.W.; Colman, P.M.; Jansonius, J.N.; Titani, K.; Walsh, K.A.; Neurath, H.
Structure of thermolysin
Nat. New Biol.
238
41-43
1972
Bacillus thermoproteolyticus
Hersh, L.B.; Morihara, K.
Comparison of the subsite specificity of the mammalian neutral endopeptidase 24.11 (enkephalinase) to the bacterial neutral endopeptidase thermolysin
J. Biol. Chem.
261
6433-6437
1986
Bacillus thermoproteolyticus
Fujiwara, K.; Tsuru, D.
Affinity chromatography of neutral and alkaline proteases from Bacillus subtilis and of thermolysin
J. Biochem.
76
883-886
1974
Bacillus thermoproteolyticus
Colman.P.M.; Jansonius, J.N.; Matthews, B.M.
The structure of thermolysin: an electron density map at 2-3 A resolution
J. Mol. Biol.
70
701-724
1972
Bacillus thermoproteolyticus
Morihara, K.; Tsuzuki, H.; Oka, T.
Comparison of the specificities of various neutral proteinases from microorganisms
Arch. Biochem. Biophys.
123
572-588
1968
Aspergillus oryzae, Bacillus thermoproteolyticus
Holland, D.R.; Tronrud, D.E.; Pley, H.W.; Flaherty, K.M.; Stark, W.; Jansonius, J.N.; McKay, D.B.; Matthews, B.W.
Structural comparison suggests that thermolysin and related neutral proteases undergo hinge-bending motion during catalysis
Biochemistry
31
11310-11316
1992
Bacillus thermoproteolyticus
Gaucher, J.F.; Selkti, M.; Prange, T.; Tomas, A.
The 2.2 A resolution structure of thermolysin (TLN) crystallized in the presence of potassium thiocyanate
Acta Crystallogr. Sect. D
58
2198-2200
2002
Bacillus thermoproteolyticus (P00800), Bacillus thermoproteolyticus
Marie-Claire, C.; Ruffet, E.; Antonczak, S.; Beaumont, A.; O'Donohue, M.; Roques, B.P.; Fournie-Zaluski, M.C.
Evidence by site-directed mutagenesis that arginine 203 of thermolysin and arginine 717 of neprilysin (neutral endopeptidase) play equivalent critical roles in substrate hydrolysis and inhibitor binding
Biochemistry
36
13938-13945
1997
Bacillus thermoproteolyticus, Bacillus thermoproteolyticus Rokko
Gaucher, J.F.; Selkti, M.; Tiraboschi, G.; Prange, T.; Roques, B.P.; Tomas, A.; Fournie-Zaluski, M.C.
Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases
Biochemistry
38
12569-12576
1999
Bacillus thermoproteolyticus (P00800)
Ligne, T.; Pauthe, E.; Monti, J.P.; Gacel, G.; Larreta-Garde, V.
Additional data about thermolysin specificity in buffer- and glycerol-containing media
Biochim. Biophys. Acta
1337
143-148
1997
Bacillus thermoproteolyticus, Bacillus thermoproteolyticus Rokko
Kudryashova, E.V.; Mozhaev, V.V.; Balny, C.
Catalytic activity of thermolysin under extremes of pressure and temperature: modulation by metal ions
Biochim. Biophys. Acta
1386
199-210
1998
Bacillus thermoproteolyticus, Bacillus thermoproteolyticus Rokko
Takeuchi, T.; Bottcher, A.; Quezada, C.M.; Meade, T.J.; Gray, H.B.
Inhibition of thermolysin and human alpha-thrombin by cobalt(III) Schiff base complexes
Bioorg. Med. Chem.
7
815-819
1999
Bacillus thermoproteolyticus
Murakami, Y.; Chiba, K.; Oda, T.; Hirata, A.
Novel kinetic analysis of enzymatic dipeptide synthesis: effect of pH and substrates on thermolysin catalysis
Biotechnol. Bioeng.
74
406-415
2001
Bacillus thermoproteolyticus
Marie-Claire, C.; Ruffet, E.; Tiraboschi, G.; Fournie-Zaluski, M.C.
Differences in transition state stabilization between thermolysin (EC 3.4.24.27) and neprilysin (EC 3.4.24.11)
FEBS Lett.
438
215-219
1998
Bacillus thermoproteolyticus
Inouye, K.; Lee, S.B.; Nambu, K.; Tonomura, B.
Effects of pH, temperature, and alcohols on the remarkable activation of thermolysin by salts
J. Biochem.
122
358-364
1997
Bacillus thermoproteolyticus
Kuzuya, K.; Inouye, K.
Effects of cobalt-substitution of the active zinc ion in thermolysin on its activity and active-site microenvironment
J. Biochem.
130
783-788
2001
Bacillus thermoproteolyticus
Muta, Y.; Inouye, K.
Inhibitory effects of alcohols on thermolysin activity as examined using a fluorescent substrate
J. Biochem.
132
945-951
2002
Bacillus thermoproteolyticus
Baltora-Rosset, S.; Aboubeker, A.; Dupradeau, F.Y.; Pauthe, E.; Gacel, G.A.; Larreta-Garde, V.; Monti, J.P.
Structural studies by 1H NMR and molecular modeling of peptide substrates of thermolysin in relation with its proteasic activity in water and glycerol
J. Biomol. Struct. Dyn.
16
1061-1074
1999
Bacillus thermoproteolyticus, Bacillus thermoproteolyticus Rokko
English, A.C.; Done, S.H.; Caves, L.S.; Groom, C.R.; Hubbard, R.E.
Locating interaction sites on proteins: the crystal structure of thermolysin soaked in 2% to 100% isopropanol
Proteins
37
628-640
1999
Bacillus thermoproteolyticus
Oyama, K.
The industrial production of aspartame
Chirality Ind.
1
237-247
1992
Bacillus proteolyticus
-
Kamo, M.; Inouye, K.; Nagata, K.; Tanokura, M.
Preliminary X-ray crystallographic analysis of thermolysin in the presence of 4 M NaCl
Acta crystallogr. Sect. D
61
710-712
2005
Bacillus thermoproteolyticus
Oneda, H.; Muta, Y.; Inouye, K.
Substrate-dependent activation of thermolysin by salt
Biosci. Biotechnol. Biochem.
68
1811-1813
2004
Bacillus thermoproteolyticus
Muta, Y.; Oneda, H.; Inouye, K.
Inhibitory effects of alcohols on the activity of human matrix metalloproteinase 7 (matrilysin)
Biosci. Biotechnol. Biochem.
68
2649-2652
2004
Homo sapiens
Kawasaki, T.; Hoshino, Y.; Ishizu, Y.; Mizushiro, Y.; Okahata, Y.
Control of hydrolysis and condensation activities of thermolysin by ultrasound irradiation
Chem. Lett.
34
1602-1603
2005
Bacillus thermoproteolyticus
-
Oda, K.; Takahashi, T.; Takada, K.; Tsunemi, M.; Ng, K.K.; Hiraga, K.; Harada, S.
Exploring the subsite-structure of vimelysin and thermolysin using FRETS-libraries
FEBS Lett.
579
5013-5018
2005
Bacillus thermoproteolyticus
Lapointe, J.; Molle, D.; Gauthier, S.F.; Pouliot, Y.
Effect of calcium on thermolysin hydrolysis of ?-casein tryptic peptides
Int. Dairy J.
14
185-193
2004
Bacillus thermoproteolyticus
NNegue, M.; Miclo, L.; Girardet, J.; Campagna, S.; Molle, D.; Gaillard, J.
Proteolysis of bovine ?-lactalbumin by thermolysin during thermal denaturation
Int. Dairy J.
16
1157-1167
2006
Bacillus thermoproteolyticus
Matsumiya, Y.; Nishikawa, K.; Aoshima, H.; Inouye, K.; Kubo, M.
Analysis of autodegradation sites of thermolysin and enhancement of its thermostability by modifying Leu155 at an autodegradation site
J. Biochem.
135
547-553
2004
Bacillus thermoproteolyticus
Kusano, M.; Yasukawa, K.; Hashida, Y.; Inouye, K.
Engineering of the pH-dependence of thermolysin activity as examined by site-directed mutagenesis of Asn112 located at the active site of thermolysin
J. Biochem.
139
1017-1023
2006
Bacillus thermoproteolyticus (P00800)
Hernandez-Ledesma, B.; Ramos, M.; Recio, I.; Amigo, L.
Effect of beta-lactoglobulin hydrolysis with thermolysin under denaturing temperatures on the release of bioactive peptides
J. Chromatogr. A
1116
31-37
2006
Bacillus thermoproteolyticus
Matsumiya, Y.; Nishikawa, K.; Inouye, K.; Kubo, M.
Mutational effect for stability in a conserved region of thermolysin
Lett. Appl. Microbiol.
40
329-334
2005
Bacillus thermoproteolyticus
Inouye, K.; Minoda, M.; Takita, T.; Sakurama, H.; Hashida, Y.; Kusano, M.; Yasukawa, K.
Extracellular production of recombinant thermolysin expressed in Escherichia coli, and its purification and enzymatic characterization
Protein Expr. Purif.
46
248-255
2006
Bacillus thermoproteolyticus
Pedersen, N.R.; Kristensen, J.B.; Bauw, G.; Ravoo, B.J.; Darcy, R.; Larsen, K.L.; Pedersen, L.H.
Thermolysin catalyzes the synthesis of cyclodextrin esters in DMSO
Tetrahedron
16
615-622
2005
Bacillus thermoproteolyticus
-
Perez-Victoria, I.; Morales, J.C.
Regioselectivity in acylation of oligosaccharides catalyzed by the metalloprotease thermolysin
Tetrahedron
62
2361-2369
2006
Bacillus thermoproteolyticus
-
Yasukawa, K.; Inouye, K.
Improving the activity and stability of thermolysin by site-directed mutagenesis
Biochim. Biophys. Acta
1774
1281-1288
2007
Bacillus thermoproteolyticus
Takita, T.; Aono, T.; Sakurama, H.; Itoh, T.; Wada, T.; Minoda, M.; Yasukawa, K.; Inouye, K.
Effects of introducing negative charges into the molecular surface of thermolysin by site-directed mutagenesis on its activity and stability
Biochim. Biophys. Acta
1784
481-488
2008
Bacillus thermoproteolyticus (P00800)
Inouye, K.; Nakamura, K.; Kusano, M.; Yasukawa, K.
Improvement in performance of affinity gels containing Gly-D-Phe as a ligand to thermolysin due to increasing the spacer chain length
Biosci. Biotechnol. Biochem.
71
2083-2086
2007
Bacillus thermoproteolyticus
Inouye, K.; Kusano, M.; Hashida, Y.; Minoda, M.; Yasukawa, K.
Engineering, expression, purification, and production of recombinant thermolysin
Biotechnol. Annu. Rev.
13
43-64
2007
Geobacillus stearothermophilus, Bacillus thermoproteolyticus, Geobacillus stearothermophilus MK232
Gragnani, A.; Sobral, C.S.; Ferreira, L.M.
Thermolysin in human cultured keratinocyte isolation
Braz. J. Biol.
67
105-109
2007
Homo sapiens
Tatsumi, C.; Hashida, Y.; Yasukawa, K.; Inouye, K.
Effects of site-directed mutagenesis of the surface residues Gln128 and Gln225 of thermolysin on its catalytic activity
J. Biochem.
141
835-842
2007
Bacillus thermoproteolyticus
Hashida, Y.; Inouye, K.
Kinetic analysis of the activation-and-inhibition dual effects of cobalt ion on thermolysin activity
J. Biochem.
141
843-853
2007
Bacillus thermoproteolyticus
Hashida, Y.; Inouye, K.
Molecular mechanism of the inhibitory effect of cobalt ion on thermolysin activity and the suppressive effect of calcium ion on the cobalt ion-dependent inactivation of thermolysin
J. Biochem.
141
879-888
2007
Bacillus thermoproteolyticus
Gokhale, N.H.; Bradford, S.; Cowan, J.A.
Stimulation and oxidative catalytic inactivation of thermolysin by copper.Cys-Gly-His-Lys
J. Biol. Inorg. Chem.
12
981-987
2007
Bacillus thermoproteolyticus
Pazhang, M.; Khajeh, K.; Ranjbar, B.; Hosseinkhani, S.
Effects of water-miscible solvents and polyhydroxy compounds on the structure and enzymatic activity of thermolysin
J. Biotechnol.
127
45-53
2006
Bacillus thermoproteolyticus
Blumberger, J.; Lamoureux, G.; Klein, M.L.
Peptide hydrolysis in thermolysin: ab initio QM/MM investigation of the Glu143-assisted water addition mechanism
J. Chem. Theory Comput.
3
1837-1850
2007
Bacillus thermoproteolyticus
Hu, Z.; Jiang, J.
Molecular dynamics simulations for water and ions in protein crystals
Langmuir
24
4215-4223
2008
Bacillus thermoproteolyticus
Owen, J.P.; Maddison, B.C.; Whitelam, G.C.; Gough, K.C.
Use of thermolysin in the diagnosis of prion diseases
Mol. Biotechnol.
35
161-170
2007
Bacillus thermoproteolyticus
Yasukawa, K.; Kusano, M.; Inouye, K.
A new method for the extracellular production of recombinant thermolysin by co-expressing the mature sequence and pro-sequence in Escherichia coli
Protein Eng. Des. Sel.
20
375-383
2007
Bacillus thermoproteolyticus
Yasukawa, K.; Kusano, M.; Nakamura, K.; Inouye, K.
Characterization of Gly-D-Phe, Gly-L-Leu, and D-Phe as affinity ligands to thermolysin
Protein Expr. Purif.
46
332-336
2006
Bacillus thermoproteolyticus
Wladyka, B.; Bista, M.; Sabat, A.J.; Bonar, E.; Grzeszczuk, S.; Hryniewicz, W.; Dubin, A.
A novel member of the thermolysin family, cloning and biochemical characterization of metalloprotease from Staphylococcus pseudintermedius
Acta Biochim. Pol.
55
525-536
2008
Staphylococcus pseudintermedius
Cronier, S.; Gros, N.; Tattum, M.H.; Jackson, G.S.; Clarke, A.R.; Collinge, J.; Wadsworth, J.D.
Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin
Biochem. J.
416
297-305
2008
Bacillus thermoproteolyticus (P00800)
Liu, Y.H.; Konermann, L.
Conformational dynamics of free and catalytically active thermolysin are indistinguishable by hydrogen/deuterium exchange mass spectrometry
Biochemistry
47
6342-6351
2008
Bacillus thermoproteolyticus
Kusano, M.; Yasukawa, K.; Inouye, K.
Insights into the catalytic roles of the polypeptide regions in the active site of thermolysin and generation of the thermolysin variants with high activity and stability
J. Biochem.
145
103-113
2009
Bacillus thermoproteolyticus
Khan, M.T.; Fuskevag, O.M.; Sylte, I.
Discovery of potent thermolysin inhibitors using structure based virtual screening and binding assays
J. Med. Chem.
52
48-61
2009
Bacillus thermoproteolyticus
Dong, M.; Liu, H.
Origins of the different metal preferences of Escherichia coli peptide deformylase and Bacillus thermoproteolyticus thermolysin: a comparative quantum mechanical/molecular mechanical study
J. Phys. Chem. B
112
10280-10290
2008
Bacillus thermoproteolyticus (P00800), Bacillus thermoproteolyticus
Marguerre, A.K.; Kraemer, R.
Lanthanide-based fluorogenic peptide substrate for the highly sensitive detection of thermolysin
Bioorg. Med. Chem. Lett.
19
5757-5759
2009
Bacillus thermoproteolyticus
Khan, M.T.; Khan, R.; Wuxiuer, Y.; Arfan, M.; Ahmed, M.; Sylte, I.
Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases
Bioorg. Med. Chem.
18
4317-4327
2010
Bacillus thermoproteolyticus
Liu, Z.; Zhang, P.; Zhou, Y.; Qin, H.; Shen, T.
Culture of human intestinal epithelial cell using the dissociating enzyme thermolysin and endothelin-3
Braz. J. Med. Biol. Res.
43
451-459
2010
Bacillus thermoproteolyticus
Adekoya, O.A.; Sylte, I.
The thermolysin family (M4) of enzymes: therapeutic and biotechnological potential
Chem. Biol. Drug Des.
73
7-16
2009
Bacillus cereus, Bacillus thermoproteolyticus
Englert, L.; Silber, K.; Steuber, H.; Brass, S.; Over, B.; Gerber, H.D.; Heine, A.; Diederich, W.E.; Klebe, G.
Fragment-based lead discovery: screening and optimizing fragments for thermolysin inhibition
ChemMedChem
5
930-940
2010
Bacillus thermoproteolyticus (P00800)
Asaoka, K.; Yasukawa, K.; Inouye, K.
Coagulation of soy proteins induced by thermolysin and comparison of the coagulation reaction with that induced by subtilisin Carlsberg
Enzyme Microb. Technol.
44
229-234
2009
Bacillus thermoproteolyticus
-
Kusano, M.; Yasukawa, K.; Inouye, K.
Synthesis of N-carbobenzoxy-L-aspartyl-L-phenylalanine methyl ester catalyzed by thermolysin variants with improved activity
Enzyme Microb. Technol.
46
320-325
2010
Bacillus thermoproteolyticus
-
Kusano, M.; Yasukawa, K.; Inouye, K.
Effects of the mutational combinations on the activity and stability of thermolysin
J. Biotechnol.
147
7-16
2010
Bacillus thermoproteolyticus
Hu, Z.; Jiang, J.
Chiral separation of racemic phenylglycines in thermolysin crystal: a molecular simulation study
J. Phys. Chem. B
113
15851-15857
2009
Bacillus thermoproteolyticus
Matsumiya, Y.; Murata, N.; Inouye, K.; Kubo, M.
Further stabilization of Leu155 mutant thermolysins by mutation of an autodegradation site
Appl. Biochem. Biotechnol.
166
735-743
2011
Bacillus sp. (in: Bacteria)
Ceruso, M.; Howe, N.; Malthouse, J.P.
Mechanism of the binding of Z-L-tryptophan and Z-L-phenylalanine to thermolysin and stromelysin-1 in aqueous solutions
Biochim. Biophys. Acta
1824
303-310
2012
Bacillus sp. (in: Bacteria), Bacillus thermoproteolyticus
Menach, E.; Yasukawa, K.; Inouye, K.
Effects of site-directed mutagenesis of the loop residue of the N-terminal domain Gly117 of thermolysin on its catalytic activity
Biosci. Biotechnol. Biochem.
74
2457-2462
2010
Bacillus thermoproteolyticus
Eijsink, V.; Matthews, B.; Vriend, G.
The role of calcium ions in the stability and instability of a thermolysin-like protease
Protein Sci.
20
1346-1355
2011
Geobacillus stearothermophilus
Birrane, G.; Bhyravbhatla, B.; Navia, M.
Synthesis of aspartame by thermolysin: an x-ray structural study
ACS Med. Chem. Lett.
5
706-710
2014
Bacillus thermoproteolyticus (P00800)
Chen, F.; Zhang, F.; Du, F.; Wang, A.; Gao, W.; Wang, Q.; Yin, X.; Xie, T.
A novel and efficient method for the immobilization of thermolysin using sodium chloride salting-in and consecutive microwave irradiation
Biores. Technol.
115
158-163
2012
Bacillus thermoproteolyticus, Bacillus thermoproteolyticus Rokko
Sato, Y.; Toyoda, T.; Shimizu-Ibuka, A.; Tamura, T.; Kobayashi-Hattori, K.; Nakamura, T.; Arai, S.; Mura, K.
Novel angiotensin I-converting enzyme inhibitory peptides found in a thermolysin-treated elastin with antihypertensive activity
Biosci. Biotechnol. Biochem.
76
1329-1333
2012
Bacillus thermoproteolyticus, Bacillus thermoproteolyticus Rokko
Adekoya, O.; Sjoeli, S.; Wuxiuer, Y.; Bilto, I.; Marques, S.; Santos, M.; Nuti, E.; Cercignani, G.; Rossello, A.; Winberg, J.; Sylte, I.
Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors
Eur. J. Med. Chem.
89
340-348
2014
Bacillus thermoproteolyticus
Ke, Q.; Chen, A.; Minoda, M.; Yoshida, H.
Safety evaluation of a thermolysin enzyme produced from Geobacillus stearothermophilus
Food Chem. Toxicol.
59
541-548
2013
Geobacillus stearothermophilus
Hardre, H.; Kuhn, L.; Albrieux, C.; Jouhet, J.; Michaud, M.; Seigneurin-Berny, D.; Falconet, D.; Block, M.; Marechal, E.
The selective biotin tagging and thermolysin proteolysis of chloroplast outer envelope proteins reveals information on protein topology and association into complexes
Front. Plant Sci.
5
203
2014
Bacillus thermoproteolyticus
Guinane, C.; Kent, R.; Norberg, S.; O'Connor, P.; Cotter, P.; Hill, C.; Fitzgerald, G.; Stanton, C.; Ross, R.
Generation of the antimicrobial peptide caseicin A from casein by hydrolysis with thermolysin enzymes
Int. Dairy J.
49
1-7
2015
Bacillus thermoproteolyticus
-
Menach, E.; Yasukawa, K.; Inouye, K.
Effects of site-directed mutagenesis of Asn116 in the beta-hairpin of the N-terminal domain of thermolysin on its activity and stability
J. Biochem.
152
231-239
2012
Bacillus thermoproteolyticus (P00800)
Yang, J.; Li, J.; Mai, Z.; Tian, X.; Zhang, S.
Purification, characterization, and gene cloning of a cold-adapted thermolysin-like protease from Halobacillus sp. SCSIO 20089
J. Biosci. Bioeng.
115
628-632
2013
Halobacillus sp. (K0EFJ2), Halobacillus sp. SCSIO 20089 (K0EFJ2)
Kim, C.; Lee, D.; Lee, C.; Ahn, I.
Dityrosine-based substrates for the selective and sensitive assay of thermolysin
J. Ind. Eng. Chem.
21
248-253
2015
Bacillus thermoproteolyticus
-
Ripp, S.; Turunen, P.; Minot, E.D.; Rowan, A.E.; Blank, K.G.
Deciphering design principles of Foerster resonance energy transfer-based protease substrates thermolysin-like protease from Geobacillus stearothermophilus as a test case
ACS Omega
3
4148-4156
2018
Geobacillus stearothermophilus
Osago, H.; Kobayashi-Miura, M.; Hamasaki, Y.; Hara, N.; Hiyoshi, M.; Tsuchiya, M.
Complete solubilization of cartilage using the heat-stable protease thermolysin for comprehensive GAG analysis
Anal. Biochem.
548
115-118
2018
Bacillus thermoproteolyticus
Rocha-Martin, J.; Fernandez-Lorente, G.; Guisan, J.
Sequential hydrolysis of commercial casein hydrolysate by immobilized trypsin and thermolysin to produce bioactive phosphopeptides
Biocatal. Biotransform.
36
159-171
2018
Bacillus thermoproteolyticus (P00800)
-
Chura-Chambi, R.M.; Fraga, T.R.; da Silva, L.B.; Yamamoto, B.B.; Isaac, L.; Barbosa, A.S.; Morganti, L.
Leptospira interrogans thermolysin refolded at high pressure and alkaline pH displays proteolytic activity against complement C3
Biotechnol. Rep.
19
e00266
2018
Leptospira interrogans serovar Copenhageni (Q72M68), Leptospira interrogans serovar Copenhageni Fiocruz L1-130 (Q72M68)
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