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casein + H2O
?
degradation
-
-
?
E-cadherin + H2O
?
ectodomain shedding
-
-
?
Fibronectin + H2O
?
degradation
-
-
?
Gelatin + H2O
?
degradation
-
-
?
Proteoglycan + H2O
?
degradation
-
-
?
tumor necrosis factor-alpha + H2O
?
activation
-
-
?
Fibronectin + H2O
?
-
production of protein fragments
-
-
?
PB-M7vis + H2O
?
-
fluorogenic substrate based on a polyamino amino dendrimer core of 14.2 kDa covalently coupled with an fluorescein-labeled peptide fluorescein(aminohexanoic acid)RPLALWRS(aminohexanoic acid)Cand with tetramethylrhodamine
-
-
?
tenascin-C + H2O
?
-
production of protein fragments
-
-
?
additional information
?
-
connexin-43 + H2O
?
-
-
-
?
connexin-43 + H2O
?
cleavage site determination, overview
-
-
?
Notch-1 + H2O
?
-
-
-
?
Notch-1 + H2O
?
MMP-7 interacts with the Notch pathway and is required for Notch activation, which leads to dedifferentiation of acinar cells to the nestin-positive transitional cell and further into duct-like epithelia. Besides being necessary for acinar transdifferentiation, it MMP-7 activity is sufficient to induce the process, overview
-
-
?
N-cadherin + H2O
?
-
-
-
-
?
N-cadherin + H2O
?
-
recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53%
-
-
?
additional information
?
-
matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor, it upregulates ErbB4 receptor expression, mediates ErbB4 localization in cytoplasm and nucleus, solubilizes the ErbB4 receptor cognate ligand heaprin-bound epidermal growth factor, and mediates the proteolytic processing of ErbB4, overview, MMP-7 shows in vitro and in vivo proliferative activity
-
-
?
additional information
?
-
-
matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor, it upregulates ErbB4 receptor expression, mediates ErbB4 localization in cytoplasm and nucleus, solubilizes the ErbB4 receptor cognate ligand heaprin-bound epidermal growth factor, and mediates the proteolytic processing of ErbB4, overview, MMP-7 shows in vitro and in vivo proliferative activity
-
-
?
additional information
?
-
MMP-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction, MMP-7 is implicated in post-MI remodeling, overview
-
-
?
additional information
?
-
MMP-7 plays a role in innate immunity and participates in the control of the pathogen Chlamydia trachomatis during the early stages of the infection
-
-
?
additional information
?
-
-
MMP-7 plays a role in innate immunity and participates in the control of the pathogen Chlamydia trachomatis during the early stages of the infection
-
-
?
additional information
?
-
MMP7 is induced upon mucosal injury in several tissues, e.g. in colon mucosa, which can be lethal to mice, enzyme-deficient mice show a much lower mortality rate compared to wild-type mice, overview
-
-
?
additional information
?
-
MMP-7 is an endopeptidase that degrades a broad range of substrates
-
-
?
additional information
?
-
-
MMP-7 cleaves E-cadherin from lung epithelium
-
-
?
additional information
?
-
-
MMP-7 assay using DQ-gelatin fluorescent substrate
-
-
?
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casein + H2O
?
degradation
-
-
?
connexin-43 + H2O
?
-
-
-
?
E-cadherin + H2O
?
ectodomain shedding
-
-
?
Fibronectin + H2O
?
degradation
-
-
?
Gelatin + H2O
?
degradation
-
-
?
Notch-1 + H2O
?
MMP-7 interacts with the Notch pathway and is required for Notch activation, which leads to dedifferentiation of acinar cells to the nestin-positive transitional cell and further into duct-like epithelia. Besides being necessary for acinar transdifferentiation, it MMP-7 activity is sufficient to induce the process, overview
-
-
?
Proteoglycan + H2O
?
degradation
-
-
?
tumor necrosis factor-alpha + H2O
?
activation
-
-
?
Fibronectin + H2O
?
-
production of protein fragments
-
-
?
N-cadherin + H2O
?
-
recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53%
-
-
?
tenascin-C + H2O
?
-
production of protein fragments
-
-
?
additional information
?
-
additional information
?
-
matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor, it upregulates ErbB4 receptor expression, mediates ErbB4 localization in cytoplasm and nucleus, solubilizes the ErbB4 receptor cognate ligand heaprin-bound epidermal growth factor, and mediates the proteolytic processing of ErbB4, overview, MMP-7 shows in vitro and in vivo proliferative activity
-
-
?
additional information
?
-
-
matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor, it upregulates ErbB4 receptor expression, mediates ErbB4 localization in cytoplasm and nucleus, solubilizes the ErbB4 receptor cognate ligand heaprin-bound epidermal growth factor, and mediates the proteolytic processing of ErbB4, overview, MMP-7 shows in vitro and in vivo proliferative activity
-
-
?
additional information
?
-
MMP-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction, MMP-7 is implicated in post-MI remodeling, overview
-
-
?
additional information
?
-
MMP-7 plays a role in innate immunity and participates in the control of the pathogen Chlamydia trachomatis during the early stages of the infection
-
-
?
additional information
?
-
-
MMP-7 plays a role in innate immunity and participates in the control of the pathogen Chlamydia trachomatis during the early stages of the infection
-
-
?
additional information
?
-
MMP7 is induced upon mucosal injury in several tissues, e.g. in colon mucosa, which can be lethal to mice, enzyme-deficient mice show a much lower mortality rate compared to wild-type mice, overview
-
-
?
additional information
?
-
-
MMP-7 cleaves E-cadherin from lung epithelium
-
-
?
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malfunction
-
MMP-7 is a proteolytic enzyme that can modify the intestinal microbial replicative niche as well as affect tumorigenesis, and Helicobacter pylori stimulates expression of MMP-7 in gastric epithelial cells in vitro, that may serve to protect the gastric mucosa from pathophysiologic processes which promote carcinogenesis. Enhanced gastritis in Helicobacter pyloriinfected mmp-7-knockout mice is strongly linked to accelerated epithelial cellular turnover. However, more severe inflammation and heightened proliferation and apoptosis are not dependent on MMP-7-mediated bacterial eradication
additional information
-
MMP-7 expression regulation, high expression of ADAM-12 observed under sustained agonist stimulation acts in a negative feedback loop to inhibit MMP-7 transcription, overview
malfunction
MMP-7-deficient mice show educed beta-catenin activation after lung injury or bleomycin treatment
malfunction
MMP-7 knockout mice experience higher mortality, elevated serum creatinine, and more severe histologic lesions after ischemic or toxic insults. Tubular apoptosis and interstitial inflammation are more prominent in MMP-7 knockout kidneys, accompanied by increased expression of FasL and other components of the extrinsic apoptotic pathway, as well as increased expression of pro-inflammatory chemokines. Ablation of MMP-7 promotes tubular cell apoptosis after acute kidney injury (AKI) augmenting renal inflammation, phenotype, overview. Exogenous MMP-7 ameliorates kidney injury in MMP-7 knockout mice after ischemia/reperfusion, mechanism underlying renal protection of MMP-7 in AKI. MMP-7 augmentes c-fos and PCNA expression induced by mitogens-rich serum in renal tubules ex vivo
physiological function
the enzyme functions to degrade extracellular matrix and other pericellular substrates including the adherens junction protein E-cadherin to promote wound healing and tissue remodeling. Matrilysin's catalytic activity regulates beta-catenin localization and signaling activation in lung epithelial cells, the enzyme activity releases beta-catenin from the cell membrane after which it is degraded in the cytosol. Matrilysin activity also increases beta-catenin translocation in the presence of a Wnt activating signal
physiological function
the primary function of MMP-7 is to break down the extracellular matrix by digesting casein, gelatins, fibronectin, and proteoglycan. MMP-7 is also capable of cleaving other substrates and plays a role in E-cadherin ectodomain shedding, tumor necrosis factor-alpha (TNF-alpha) release, and activation of other proteinases. Exogenous MMP-7 ameliorates kidney injury in MMP-7 knockout mice after ischemia/reperfusion. In vitro, MMP-7 protects tubular epithelial cells against apoptosis by directly degrading FasL. In isolated tubules ex vivo, MMP-7 promotes cell proliferation by degrading E-cadherin and thereby liberating beta-catenin, priming renal tubules for regeneration. Mechanism underlying renal protection of MMP-7 in acute kidney injury (AKI), overview
physiological function
-
matrilysin regulates pulmonary influx and localization of dendritic cells that express CD103, and E-cadherin cleavage may activate CD103+ dendritic cells to limit inflammation and inhibit fibrosis, overview. Matrilysin effects on CD103-E-cadherin interactions in lung injury, matrilysin expression is increased in lung injury, and it cleaves E-cadherin from injured lung epithelium, overview. Matrilysin regulates pulmonary neutrophil clearance in cronic lung injury, overview
physiological function
-
MMP-7 controls the transcription of the disintegrin and metalloproteinase-12, ADAM-12, the major metalloproteinase implicated in cardiac hypertrophy. Matrix metalloproteinase-7 and ADAM-12 form a novel signaling axis in a variety of cardiovascular processes, including hypertension and hypertrophy, overview. Induction of acute hypertension by vasoconstrictors, i.e. catecholamines, angiotensin II, and the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester, require the posttranscriptional activation of vascular MMP-7. Sustained agonist stimulation regulates the development and progression of hypertension and hypertrophy processes through posttranscriptional, short-term and transcriptional, long-term mechanisms involving metalloproteinases such as MMP-7 and ADAM-12
physiological function
-
MMP-7 deletion improves survival after myocardial infarction
physiological function
-
MMP-7 mediates cleavage of N-cadherin and promotes vascular smooth muscle cell apoptosis, that can lead to thinning of the fibrous cap and plaque instability
physiological function
-
MMP7 is required for cell migration. Lung injury promotes the expression of matrix metalloproteinase-7, which is required for neutrophil recruitment and re-epithelialization. MMP7 shedding of syndecan-1 facilitates re-epithelialization by affecting alpha2beta1 integrin activation. MMP7 releases syndecan-1 restrictions on wound closure, overview
physiological function
-
role of MMP7 in colon cancer progression, overview. MMP7 is required for tumor formation, but not for the invasion or fibrosis of the colon cancer whose SMAD4-dependent TGF-beta family signaling is blocked
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additional information
construction of MMP-7 knockout mice
additional information
construction of MMP-7 knockout mice, which show higher content of pathogens in the small intestine two weeks after vaginal infection with Chlamydia trachomatis mouse pneumonitis as compared to wild-type C57BL/6 mice, because MMP-7 KO mice are deficient in active intestinal alpha-defensins, which play a role in regulating colonization of the gastrointestinal tract by Chlamydia, overview
additional information
-
construction of MMP-7 knockout mice, which show higher content of pathogens in the small intestine two weeks after vaginal infection with Chlamydia trachomatis mouse pneumonitis as compared to wild-type C57BL/6 mice, because MMP-7 KO mice are deficient in active intestinal alpha-defensins, which play a role in regulating colonization of the gastrointestinal tract by Chlamydia, overview
additional information
enzyme-deficient MMP7-/- mice show a lower mortality rate compared to wild-type mice in case of colon mucosal injury and inflammation, while neutrophil influx is similar in both cases, overview
additional information
MMP-7-deficient cells do not show activation of Notch-1, which can be restored by recombinant MMP-7, phenotype, overview
additional information
generation of MMP-7 knockout mice
additional information
-
ApcMin/+ Mmp7-/- double-deficient mice demonstrate reciprocal relationships of Mmp7 expression and the levels of the collagens Col1a2, Col5a2, Col6a2, and Col6a3 in vivo
additional information
-
construction of MMP-7 null mice that show lower levels of full-length peroxiredoxin-1 and -2 and higher levels of the full-length peroxiredoxin-3, suggesting MMP-7 deletion may also indirectly regulate protein levels through nonenzymatic mechanisms. Null mice also show reduced fibronectin and tenascin-C fragment generation, which is restored by exogenous administration of MMP-7
additional information
-
introduction of an Mmp7 knockout mutation into the cis-Apc/Smad4 mutant mouse, a model of invasive colon cancer in which SMAD4-dependent TGF-beta family signaling is inactivated. Lack of MMP7 reduces the number and size of tumors in the cis-Apc/Smad4 mice
additional information
-
knockdown of MMP-7 by siRNA attenuates hypertension, inhibits ADAM-12 overexpression, and prevents cardiac hypertrophy. Resistance to acute hypertension in mice lacking active MMP-7
additional information
-
MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview
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McIntyre, J.O.; Fingleton, B.; Wells, K.S.; Piston, D.W.; Lynch, C.C.; Gautam, S.; Matrisian, L.M.
Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity
Biochem. J.
377
617-628
2004
Mus musculus
brenda
Lynch, C.C.; Vargo-Gogola, T.; Martin, M.D.; Fingleton, B.; Crawford, H.C.; Matrisian, L.M.
Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor
Cancer Res.
67
6760-6767
2007
Homo sapiens (P09237), Mus musculus (Q10738), Mus musculus, Mus musculus C57BL/6 (Q10738)
brenda
Lindsey, M.L.; Escobar, G.P.; Mukherjee, R.; Goshorn, D.K.; Sheats, N.J.; Bruce, J.A.; Mains, I.M.; Hendrick, J.K.; Hewett, K.W.; Gourdie, R.G.; Matrisian, L.M.; Spinale, F.G.
Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction
Circulation
113
2919-2928
2006
Mus musculus (Q10738)
brenda
Pal, S.; Schmidt, A.P.; Peterson, E.M.; Wilson, C.L.; de la Maza, L.M.
Role of matrix metalloproteinase-7 in the modulation of a Chlamydia trachomatis infection
Immunology
117
213-219
2006
Mus musculus (Q10738), Mus musculus, Mus musculus C57BL/6 (Q10738)
brenda
Swee, M.; Wilson, C.L.; Wang, Y.; McGuire, J.K.; Parks, W.C.
Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients
J. Leukoc. Biol.
83
1404-1412
2008
Mus musculus (Q10738), Mus musculus C57BL/6 (Q10738)
brenda
Sawey, E.T.; Johnson, J.A.; Crawford, H.C.
Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway
Proc. Natl. Acad. Sci. USA
104
19327-19332
2007
Mus musculus (Q10738), Mus musculus C57/BL6J (Q10738)
brenda
Chen, P.; McGuire, J.K.; Hackman, R.C.; Kim, K.H.; Black, R.A.; Poindexter, K.; Yan, W.; Liu, P.; Chen, A.J.; Parks, W.C.; Madtes, D.K.
Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity
Am. J. Pathol.
172
1256-1270
2008
Mus musculus (Q10738), Mus musculus
brenda
Guillen-Ahlers, H.; Buechler, S.A.; Suckow, M.A.; Castellino, F.J.; Ploplis, V.A.
Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice
Carcinogenesis
29
1421-1427
2008
Mus musculus
brenda
Manicone, A.M.; Huizar, I.; McGuire, J.K.
Matrilysin (matrix metalloproteinase-7) regulates anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 (alphaEbeta7-integrin)
Am. J. Pathol.
175
2319-2331
2009
Mus musculus, Mus musculus C57BL/6
brenda
Ogden, S.R.; Noto, J.M.; Allen, S.S.; Patel, D.A.; Romero-Gallo, J.; Washington, M.K.; Fingleton, B.; Israel, D.A.; Lewis, N.D.; Wilson, K.T.; Chaturvedi, R.; Zhao, Z.; Shyr, Y.; Peek, R.M.
Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice
Cancer Res.
70
30-35
2010
Mus musculus, Mus musculus C57BL/6
brenda
Williams, H.; Johnson, J.L.; Jackson, C.L.; White, S.J.; George, S.J.
MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis
Cardiovasc. Res.
87
137-146
2010
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
brenda
Wang, X.; Chow, F.L.; Oka, T.; Hao, L.; Lopez-Campistrous, A.; Kelly, S.; Cooper, S.; Odenbach, J.; Finegan, B.A.; Schulz, R.; Kassiri, Z.; Lopaschuk, G.D.; Fernandez-Patron, C.
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy
Circulation
119
2480-2489
2009
Mus musculus, Rattus norvegicus
brenda
Chiao, Y.A.; Zamilpa, R.; Lopez, E.F.; Dai, Q.; Escobar, G.P.; Hakala, K.; Weintraub, S.T.; Lindsey, M.L.
In vivo matrix metalloproteinase-7 substrates identified in the left ventricle post-myocardial infarction using proteomics
J. Proteome Res.
9
2649-2657
2010
Mus musculus
brenda
Kitamura, T.; Biyajima, K.; Aoki, M.; Oshima, M.; Taketo, M.
Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas
Lab. Invest.
89
98-105
2009
Homo sapiens, Mus musculus
brenda
Chen, P.; Abacherli, L.E.; Nadler, S.T.; Wang, Y.; Li, Q.; Parks, W.C.
MMP7 shedding of syndecan-1 facilitates re-epithelialization by affecting alpha2beta1 integrin activation
PLoS ONE
4
e6565
2009
Mus musculus
brenda
Rims, C.; McGuire, J.
Matrilysin (MMP-7) catalytic activity regulates beta-catenin localization and signaling activation in lung epithelial cells
Exp. Lung Res.
40
126-136
2014
Mus musculus (Q10738), Mus musculus C57BL/6 (Q10738)
brenda
Fu, H.; Zhou, D.; Zhu, H.; Liao, J.; Lin, L.; Hong, X.; Hou, F.F.; Liu, Y.
Matrix metalloproteinase-7 protects against acute kidney injury by priming renal tubules for survival and regeneration
Kidney Int.
95
1167-1180
2019
Homo sapiens (P09237), Mus musculus (Q10738)
brenda