Reference on EC 3.4.24.21 - astacin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dumermuth, E.; Sterchi, E.E.; Jiang, W.; Wolz, R.L.; Bond, J.S.; Flannery, A.V.; Beynon, R.J.
The astacin family of metalloendopeptidases
J. Biol. Chem.
266
21381-21385
1991
BRENDA: Astacus astacus
Textmining: Astacoidea, Homo sapiens, Xenopus laevis, Mus musculus
Wolz, R.L.
A kinetic comparison of the homologous proteases astacin and meprin A
Arch. Biochem. Biophys.
310
144-151
1994
BRENDA: Astacus astacus
Textmining: Astacoidea, Mus musculus
Krauhs, E.; Dörsam, H.; Little, M.; Zwilling, R.; Ponstingl, H.
A protease from Astacus fluviatilis as an aid in protein sequencing
Anal. Biochem.
119
153-157
1982
Astacus astacus
Titani, K.; Torff, H.J.; Hormel, S.; Kumar, S.; Walsh, K.A.; Rödl, J.; Neurath, H.; Zwilling, R.
Amino acid sequence of a unique protease from the crayfish Astacus fluviatilis
Biochemistry
26
222-226
1987
Astacus astacus
Stöcker, W.; Wolz, R.L.; Zwilling, R.; Strydom, D.J.; Auld, D.S.
Astacus protease, a zinc metalloenzyme
Biochemistry
27
5026-5032
1988
Astacus astacus
-
Stöcker, W.; Ng, M.; Auld, D.S.
Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease
Biochemistry
29
10418-10425
1990
BRENDA: Astacus astacus
Textmining: Astacus
Bode, W.; Gomis-Ruth, F.X.; Huber, R.; Zwilling, R.; Stöcker, W.
Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases
Nature
358
164-167
1992
BRENDA: Astacus astacus
Textmining: Astacoidea, Echinoidea, Homo sapiens
Gomis-Ruth, F.X.; Stöcker, W.; Huber, R.; Zwilling, R.; Bode, W.
Refined 1.8 A X-ray crystal structure of astacin, a zinc-endopeptidase from the crayfish Astacus astacus L. Structure determination, refinement, molecular structure and comparison with thermolysin
J. Mol. Biol.
229
945-968
1993
BRENDA: Astacus astacus
Textmining: Astacoidea, Electron
Stöcker, W.; Gomis-Ruth, F.X.; Bode, W.; Zwilling, R.
Implications of the three-dimensional structure of astacin for the structure and function of the astacin family of zinc-endopeptidases
Eur. J. Biochem.
214
215-231
1993
BRENDA: Astacus astacus
Textmining: amphibia, Astacoidea, echinodermata, Hexapoda, Homo sapiens, Rodentia
Gomis-Ruth, F.X.; Grams, F.; Yiallouros, I.; Nar, H.; Kusthardt, U.; Zwilling, R.; Bode, W.; Stöcker, W.
Crystal structures, spectroscopic features, and catalytic properties of cobalt(II), copper(II), nickel(II), and mercury(II) derivatives of the zinc endopeptidase astacin. A correlation of structure and proteolytic activity
J. Biol. Chem.
269
17111-17117
1994
BRENDA: Astacus astacus
Textmining: Astacoidea, Electron
Zwilling, R.; Neurath, H.
Invertebrate proteases
Methods Enzymol.
80C
633-664
1981
Astacus astacus, Carcinus maenas, Astacus leptodactylus
-
Bode, W.; Gomis-Ruth, F.X.; Stöckler, W.
Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the metzincins
FEBS Lett.
331
134-140
1993
BRENDA: Astacus astacus
Textmining: snake, Astacoidea, Serratia
Gomis-Ruth, F.X.; Kress, L.F.; Kellermann, J.; Mayr, I.; Lee, X.; Huber, R.; Bode, W.
Refined 2.0 A X-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. Primary and tertiary structure determination, refinement, molecular structure and comparison with astacin, collagenase and thermolysin
J. Mol. Biol.
239
513-544
1994
snake, Crotalus adamanteus, Electron
Yasumasu, S.; Yamada, K.; Akasaka, K.; Mitsunaga, K.; Iuchi, I.; Shimada, H.; Yamagami, K.
Isolation of cDNAs for LCE and HCE, two constituent proteases of the hatching enzyme of Oryzias latipes, and concurrent expression of their mRNAs during development
Dev. Biol.
153
250-258
1992
Echinoidea, Oryzias latipes, Oryzias latipes (P31581)
Tarentino, A.L.; Quinones, G.; Grimwood, B.G.; Hauer, C.R.; Plummer, T.H.
Molecular cloning and sequence analysis of flavastacin: an O-glycosylated prokaryotic zinc metalloendopeptidase
Arch. Biochem. Biophys.
319
281-285
1995
Elizabethkingia meningoseptica
Yiallouros, I.; Vassiliou, S.; Yiotakis, A.; Zwilling, R.; Stoecker, W.; Dive, V.
Phosphinic peptides, the first potent inhibitors of astacin, behave as extremely slow-binding inhibitors
Biochem. J.
331
375-379
1998
BRENDA: Astacus astacus
Textmining: Astacoidea
Reyda, S.; Jacob, E.; Zwilling, R.; Stoecker, W.
cDNA cloning, bacterial expression, in vitro renaturation and affinity purification of the zinc endopeptidase astacin
Biochem. J.
344
851-857
1999
BRENDA: Astacus astacus
Textmining: Escherichia coli, Astacoidea, Dialysis
Doll, B.A.; Villa, J.P.; Ishmael, F.T.; Bond, J.S.
Zinc ligands in an astacin family metalloprotease meprin A
Biol. Chem.
383
1167-1173
2002
Mus musculus
Moehrlen, F.; Hutter, H.; Zwilling, R.
The astacin protein family in Caenorhabditis elegans
Eur. J. Biochem.
270
4909-4920
2003
Caenorhabditis elegans, Bacteria, Nematoda, vertebrata, Homo sapiens
Hung, C.H.; Huang, H.R.; Huang, C.J.; Huang, F.L.; Chang, G.D.
Purification and cloning of carp nephrosin, a secreted zinc endopeptidase of the astacin family
J. Biol. Chem.
272
13772-13778
1997
BRENDA: Cyprinus carpio (O42326), Cyprinus carpio
Textmining: Astacoidea, Oryzias latipes, Mus musculus
Bertenshaw, G.P.; Turk, B.E.; Hubbard, S.J.; Matters, G.L.; Bylander, J.E.; Crisman, J.M.; Cantley, L.C.; Bond, J.S.
Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity
J. Biol. Chem.
276
13248-13255
2001
Mus musculus
Villa, J.P.; Bertenshaw, G.P.; Bond, J.S.
Critical Amino Acids in the Active Site of Meprin Metalloproteinases for Substrate and Peptide Bond Specificity
J. Biol. Chem.
278
42545-42550
2003
Astacoidea
Wolfsberg, T.G.; Bazan, J.F.; Blobel, C.P.; Myles, D.G.; Primakoff, P.; White, J.M.
The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications
Proc. Natl. Acad. Sci. USA
90
10783-10787
1993
snake
Baumann, U.; Wu, S.; Flaherty, K.M.; McKay, D.B.
Three-dimensional structure of the alkaline protease of Pseudomonas aeruginosa: a two-domain protein with a calcium binding parallel beta roll motif
EMBO J.
12
3357-3364
1993
Astacoidea, Bacteria, Pseudomonas aeruginosa
Tsai, P.L.; Chen, C.H.; Huang, C.J.; Chou, C.M.; Chang, G.D.
Purification and cloning of an endogenous protein inhibitor of carp nephrosin, an astacin metalloproteinase
J. Biol. Chem.
279
11146-11155
2004
Cyprinus carpio
Kawaguchi, M.; Yasumasu, S.; Hiroi, J.; Naruse, K.; Inoue, M.; Iuchi, I.
Evolution of teleostean hatching enzyme genes and their paralogous genes
Dev. Genes Evol.
216
769-784
2006
Oryzias latipes, Oryzias latipes (Q14TH9), Chondrichthyes, Danio rerio, Takifugu, Euteleostei, Plecoglossus altivelis
Foradori, M.J.; Tillinghast, E.K.; Smith, J.S.; Townley, M.A.; Mooney, R.E.
Astacin family metallopeptidases and serine peptidase inhibitors in spider digestive fluid
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
143
257-268
2006
BRENDA: Argiope aurantia (P84748), Argiope aurantia
Textmining: Crustacea, vertebrata, Argiope
Semenova, S.A.; Rudenskaya, G.N.; Rebrikov, D.V.; Isaev, V.A.
cDNA cloning, purification and properties of Paralithodes camtschatica metalloprotease
Protein Pept. Lett.
13
571-575
2006
BRENDA: Paralithodes camtschaticus
Textmining: Astacoidea, Chaceon affinis
Ambort, D.; Stalder, D.; Lottaz, D.; Huguenin, M.; Oneda, B.; Heller, M.; Sterchi, E.E.
A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin
FEBS J.
275
4490-4509
2008
Canis lupus familiaris
Becker-Pauly, C.; Bruns, B.C.; Damm, O.; Schuette, A.; Hammouti, K.; Burmester, T.; Stoecker, W.
News from an ancient world: two novel astacin metalloproteases from the horseshoe crab
J. Mol. Biol.
385
236-248
2009
BRENDA: Limulus polyphemus
Textmining: Hydra, Doryteuthis pealeii
Guevara, T.; Yiallouros, I.; Kappelhoff, R.; Bissdorf, S.; Stoecker, W.; Gomis-Rueth, F.X.
Proenzyme structure and activation of astacin metallopeptidase
J. Biol. Chem.
285
13958-13965
2010
BRENDA: Astacus astacus (Q9U918), Astacus astacus
Textmining: Astacoidea
Stepek, G.; McCormack, G.; Page, A.
Collagen processing and cuticle formation is catalysed by the astacin metalloprotease DPY-31 in free-living and parasitic nematodes
Int. J. Parasitol.
40
533-542
2010
BRENDA: Brugia malayi, Caenorhabditis elegans, Haemonchus contortus
Textmining: Nematoda, Nematodes
Tsuchiya, S.; Simmer, J.P.; Hu, J.C.; Richardson, A.S.; Yamakoshi, F.; Yamakoshi, Y.
Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp)
J. Bone Miner. Res.
26
220-228
2011
Sus scrofa
Jing, Y.; Toubarro, D.; Hao, Y.; Simoes, N.
Cloning, characterisation and heterologous expression of an astacin metalloprotease, Sc-AST, from the entomoparasitic nematode Steinernema carpocapsae
Mol. Biochem. Parasitol.
174
101-108
2010
BRENDA: Steinernema carpocapsae (D2KBH9), Steinernema carpocapsae
Textmining: Astacus astacus, Caenorhabditis elegans, Escherichia coli, Hexapoda, Nematoda
Stepek, G.; McCormack, G.; Birnie, A.J.; Page, A.P.
The astacin metalloprotease moulting enzyme NAS-36 is required for normal cuticle ecdysis in free-living and parasitic nematodes
Parasitology
138
237-248
2011
BRENDA: Brugia malayi, Caenorhabditis elegans
Textmining: Nematodes, Nematoda, Haemonchus contortus, Homo sapiens, Ovis aries, Metazoa
Gomis-Rueth, F.X.; Trillo-Muyo, S.; Stoecker, W.
Functional and structural insights into astacin metallopeptidases
Biol. Chem.
393
1027-1041
2012
Caenorhabditis elegans, Cyprinus carpio, Onchocerca volvulus, Trichinella spiralis, Astacus astacus (P07584)
Baska, P.; Wisniewski, M.; Krzyzowska, M.; Dlugosz, E.; Zygner, W.; Gorski, P.; Wedrychowicz, H.
Molecular cloning and characterisation of in vitro immune response against astacin-like metalloprotease Ace-MTP-2 from Ancylostoma ceylanicum
Exp. Parasitol.
133
472-482
2013
BRENDA: Ancylostoma ceylanicum (Q0Z889), Ancylostoma ceylanicum
Textmining: Homo sapiens, Ancylostomatoidea
Hong, C.S.; Saint-Jeannet, J.P.
Xhe2 is a member of the astacin family of metalloproteases that promotes Xenopus hatching
Genesis
52
946-951
2014
BRENDA: Xenopus laevis (Q63ZG3)
Textmining: Xenopus
Stepek, G.; McCormack, G.; Winter, A.D.; Page, A.P.
A highly conserved, inhibitable astacin metalloprotease from Teladorsagia circumcincta is required for cuticle formation and nematode development
Int. J. Parasitol.
45
345-355
2015
BRENDA: Teladorsagia circumcincta (A0A0C5PRQ1), Teladorsagia circumcincta, Haemonchus contortus (D5FM33), Haemonchus contortus, Caenorhabditis elegans (P98060), Caenorhabditis elegans, Haemonchus contortus ISE (D5FM33), Caenorhabditis elegans N2 (P98060), Teladorsagia circumcincta MTci5 (A0A0C5PRQ1)
Textmining: Nematoda, Homo sapiens, Nematodes
Liang, Y.; Bai, D.; Yang, G.; Wei, D.; Guo, M.; Yan, S.; Wu, X.; Ning, B.
Effect of astacin on growth and color formation of juvenile red-white ornamental carp (Cyprinus carpio var. koi L)
Isr. J. Aquacult.
64
0000
2012
Cyprinus carpio
-
Chen, S.L.; Li, Z.S.; Fang, W.H.
Theoretical investigation of astacin proteolysis
J. Inorg. Biochem.
111
70-79
2012
Astacus astacus (P07584)
Morgon, A.; Belisario-Ferrari, M.; Trevisan-Silva, D.; Meissner, G.; Vuitika, L.; Marin, B.; Tashima, A.; Gremski, L.; Gremski, W.; Senff-Ribeiro, A.; Veiga, S.; Chaim, O.
Expression and immunological cross-reactivity of LALP3, a novel astacin-like metalloprotease from brown spider (Loxosceles intermedia) venom
Biochimie
128-129
8-19
2016
BRENDA: Loxosceles intermedia (C9D7R3), Loxosceles intermedia
Textmining: Bacteria, Escherichia coli, Loxosceles
Schneppenheim, J.; Scharfenberg, F.; Lucius, R.; Becker-Pauly, C.; Arnold, P.
Meprin beta and BMP-1 are differentially regulated by CaCl2
Cell Calcium
65
8-13
2017
Homo sapiens (P13497), Homo sapiens
Sarkar, I.
To compare the active sites of a series of astacin family proteases by multiple sequence alignment and homology modelling methods
Comput. Adv. Commun. Circ. Syst.: ICCACCS 2014
335
145-150
2015
Homo sapiens (P13497)
-
Chaudhuri, A.; Chakraborty, S.
Structure-activity relationship of astacin metalloproteases A comparative study using EDTA
Curr. Enzyme Inhib.
14
131-140
2018
Coturnix japonica (P42662), Homo sapiens (Q6HA08)
-
Isolani, M.E.; Batistoni, R.; Ippolito, C.; Bianucci, A.M.; Marracci, S.; Rossi, L.
Astacin gene family of metalloproteinases in planarians structural organization and tissue distribution
Gene Expr. Patterns
28
77-86
2018
BRENDA: Schmidtea mediterranea, Schmidtea mediterranea (A0A060Q6V2), Schmidtea mediterranea (A0A060Q6Y6), Schmidtea mediterranea (A0A060Q714), Schmidtea mediterranea (A0A060Q715), Schmidtea mediterranea (A0A060Q750), Schmidtea mediterranea (A0A060Q785), Schmidtea mediterranea (A0A060Q786), Schmidtea mediterranea (I1ZIC3)
Textmining: Dugesia japonica
Schlenzig, D.; Wermann, M.; Ramsbeck, D.; Moenke-Wedler, T.; Schilling, S.
Expression, purification and initial characterization of human meprin beta from Pichia pastoris
Protein Expr. Purif.
116
75-81
2015
Homo sapiens, Homo sapiens (Q16820)
Lhomond, G; Ghiglione, C; Lepage, T; Gache, C
Structure of the gene encoding the sea urchin blastula protease 10 (BP10), a member of the astacin family of Zn2+-metalloproteases.
Eur J Biochem
238
744-51
1996
Echinoidea
Jiang, W; Flannery, AV
Correlation of the exon/intron organization to the secondary structures of the protease domain of mouse meprin alpha subunit.
Gene
189
65-71
1997
Mus musculus
da Silva, GF; Reuille, RL; Ming, LJ; Livingston, BT
Overexpression and mechanistic characterization of blastula protease 10, a metalloprotease involved in sea urchin embryogenesis and development.
J Biol Chem
281
10737-44
2006
Echinoidea, Deuterostomia, Escherichia coli
LaFlamme, BA; Ram, KR; Wolfner, MF
The Drosophila melanogaster seminal fluid protease "seminase" regulates proteolytic and post-mating reproductive processes.
PLoS Genet
8
e1002435
2012
Drosophila melanogaster, Mammalia, Drosophila, animal
Shibata, Y; Iwamatsu, T; Suzuki, N; Young, G; Naruse, K; Nagahama, Y; Yoshikuni, M
An oocyte-specific astacin family protease, alveolin, is released from cortical granules to trigger egg envelope hardening during fertilization in medaka (Oryzias latipes).
Dev Biol
372
239-48
2012
Oryzias latipes, Transformation
Schlenzig, D; Schilling, S
Heterologous Expression of the Astacin Protease Meprin ? in Pichia pastoris.
Methods Mol Biol
1579
35-45
2017
Komagataella pastoris
Nishida, S; Fujita, T; Kohno, N; Atoda, H; Morita, T; Takeya, H; Kido, I; Paine, MJ; Kawabata, S; Iwanaga, S
cDNA cloning and deduced amino acid sequence of prothrombin activator (ecarin) from Kenyan Echis carinatus venom.
Biochemistry
34
1771-8
1995
Astacoidea
Yan, L; Leontovich, A; Fei, K; Sarras, MP
Hydra metalloproteinase 1: a secreted astacin metalloproteinase whose apical axis expression is differentially regulated during head regeneration.
Dev Biol
219
115-28
2000
Hydra
Vogt, G; Stöcker, W; Storch, V; Zwilling, R
Biosynthesis of Astacus protease, a digestive enzyme from crayfish.
Histochemistry
91
373-81
1989
Astacus, Astacoidea, Astacus astacus
Jiang, W; Gorbea, CM; Flannery, AV; Beynon, RJ; Grant, GA; Bond, JS
The alpha subunit of meprin A. Molecular cloning and sequencing, differential expression in inbred mouse strains, and evidence for divergent evolution of the alpha and beta subunits.
J Biol Chem
267
9185-93
1992
Mus musculus, Mus sp., Rattus
Bond, JS; Rojas, K; Overhauser, J; Zoghbi, HY; Jiang, W
The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively.
Genomics
25
300-3
1995
Homo sapiens
Hahn, D; Illisson, R; Metspalu, A; Sterchi, EE
Human N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin): genomic structure of the alpha and beta subunits.
Biochem J
346 Pt 1
83-91
2000
Homo sapiens
Leuenberger, B; Hahn, D; Pischitzis, A; Hansen, MK; Sterchi, EE
Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion.
Biochem J
369
659-65
2003
Homo sapiens
Becker, C; Kruse, MN; Slotty, KA; Köhler, D; Harris, JR; Rösmann, S; Sterchi, EE; Stöcker, W
Differences in the activation mechanism between the alpha and beta subunits of human meprin.
Biol Chem
384
825-31
2003
Homo sapiens, Mus musculus, Rattus
Lottaz, D; Buri, C; Monteleone, G; Rösmann, S; Macdonald, TT; Sanderson, IR; Sterchi, EE
Compartmentalised expression of meprin in small intestinal mucosa: enhanced expression in lamina propria in coeliac disease.
Biol Chem
388
337-41
2007
Homo sapiens
Arnold, P; Koopmann, L; Peters, F; Birkenfeld, F; Goff, SV; Damm, T; Qin, C; Moali, C; Lucius, R; Becker-Pauly, C
Deficiency of the DSPP-cleaving enzymes meprin ? and meprin ? does not result in dentin malformation in mice.
Cell Tissue Res
2016
Mus sp.
Hwang, SP; Partin, JS; Lennarz, WJ
Characterization of a homolog of human bone morphogenetic protein 1 in the embryo of the sea urchin, Strongylocentrotus purpuratus.
Development
120
559-68
1994
Astacoidea
Fukagawa, M; Suzuki, N; Hogan, BL; Jones, CM
Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase.
Dev Biol
163
175-83
1994
Mus musculus, Drosophila, Homo sapiens
Suzuki, N; Labosky, PA; Furuta, Y; Hargett, L; Dunn, R; Fogo, AB; Takahara, K; Peters, DM; Greenspan, DS; Hogan, BL
Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid.
Development
122
3587-95
1996
Mus musculus
Novelli, J; Ahmed, S; Hodgkin, J
Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target.
Genetics
168
1259-73
2004
Caenorhabditis elegans
Ratanabanangkoon, K; Archariyasucha, R
Effects of aliphatic dicarboxylic acids on neuromuscular inhibition produced by Naja naja siamensis toxin 3 and D-tubocurarine.
Toxicon
15
459-60
1977
Naja naja, Naja siamensis
Wolz, RL; Zeggaf, C; Stöcker, W; Zwilling, R
Thiol containing compounds and amino acid hydroxamates as reversible synthetic inhibitors of Astacus protease.
Arch Biochem Biophys
281
275-81
1990
Astacus, Astacoidea
Wolz, RL; Zwilling, R
Kinetic evidence for cooperative binding of two ortho-phenanthroline molecules to astacus protease during metal removal.
J Inorg Biochem
35
157-67
1989
Astacoidea, Astacus
Kondrakov, VI; Arsen'ev, AS; Utkin, IuN; Karlsson, E; Gurevich, AZ
[NMR study of the spatial structure of the Naja naja siamensis toxin 3]
Bioorg Khim
10
869-90
1984
Naja naja, Naja siamensis
Kondakov, VI; Arsen'ev, AS; Pluzhnikov, KA; Tsetlin, VI; Bystrov, VF
[2-D-NMR study of the conformation characteristics of toxin 3 from Naja naja siamensis venom]
Bioorg Khim
10
1606-28
1984
Naja naja, Naja siamensis
Kukongviriyapan, V; Poopyruchpong, N; Ratanabanangkoon, K
Some parameters of affinity chromatography in the purification of antibody against Naja naja siamensis toxin 3.
J Immunol Methods
49
97-104
1982
Naja naja, Naja siamensis
Khupulsup, K; Poopyruchpong, N; Petchclai, B; Ratanabanangkoon, K
A passive hemagglutination test for antibody to Naja naja siamensis toxin 3.
Toxicon
19
863-6
1981
Naja naja, Naja siamensis
Meier, UC; Boetzel, J; Kellermann, J; Mann, K; Billich, A; Stöcker, W; Schramm, HJ
The cleavage of the bait region of alpha 2-macroglobulin by human immunodeficiency virus proteinases and by astacin.
Ann N Y Acad Sci
737
431-3
1994
Human Immunodeficiency Virus
Yan, L; Pollock, GH; Nagase, H; Sarras, MP
A 25.7 x 10(3) M(r) hydra metalloproteinase (HMP1), a member of the astacin family, localizes to the extracellular matrix of Hydra vulgaris in a head-specific manner and has a developmental function.
Development
121
1591-602
1995
Hydra, Hydra vulgaris
Elaroussi, MA; DeLuca, HF
A new member to the astacin family of metalloendopeptidases: a novel 1,25-dihydroxyvitamin D-3-stimulated mRNA from chorioallantoic membrane of quail.
Biochim Biophys Acta
1217
1-8
1994
Astacoidea, Drosophila, Homo sapiens, Oryzias latipes, quail, Xenopus laevis
Olianas, MC; Adem, A; Karlsson, E; Onali, P
Rat striatal muscarinic receptors coupled to the inhibition of adenylyl cyclase activity: potent block by the selective m4 ligand muscarinic toxin 3 (MT3).
Br J Pharmacol
118
283-8
1996
Rattus
Wang, JQ; Jolkkonen, M; McGinty, JF
The muscarinic toxin 3 augments neuropeptide mRNA in rat striatum in vivo.
Eur J Pharmacol
334
43-7
1997
Rattus
Geier, G; Zwilling, R
Cloning and characterization of a cDNA coding for Astacus embryonic astacin, a member of the astacin family of metalloproteases from the crayfish Astacus astacus.
Eur J Biochem
253
796-803
1998
Astacus, Astacus astacus, Astacoidea, Oryzias latipes, Xenopus, Echinoidea, Metazoa
Olianas, MC; Adem, A; Karlsson, E; Onali, P
Identification of rat brain muscarinic M4 receptors coupled to cyclic AMP using the selective antagonist muscarinic toxin 3.
Eur J Pharmacol
357
235-42
1998
Rattus, Hippocampus
Kumpfmüller, G; Rybakine, V; Takahashi, T; Fujisawa, T; Bosch, TC
Identification of an astacin matrix metalloprotease as target gene for Hydra foot activator peptides.
Dev Genes Evol
209
601-7
1999
Hydra
Yan, L; Fei, K; Zhang, J; Dexter, S; Sarras, MP
Identification and characterization of hydra metalloproteinase 2 (HMP2): a meprin-like astacin metalloproteinase that functions in foot morphogenesis.
Development
127
129-41
2000
Anemone, Hydra, Hydra vulgaris, Podocoryna
Möhrlen, F; Baus, S; Gruber, A; Rackwitz, HR; Schnölzer, M; Vogt, G; Zwilling, R
Activation of pro-astacin. Immunological and model peptide studies on the processing of immature astacin, a zinc-endopeptidase from the crayfish Astacus astacus.
Eur J Biochem
268
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Astacus, Astacus astacus, Astacoidea, Bacteria, Homo sapiens
Zhan, B; Hotez, PJ; Wang, Y; Hawdon, JM
A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases.
Mol Biochem Parasitol
120
291-6
2002
Ancylostoma caninum
Quesada, V; Sánchez, LM; Alvarez, J; López-OtÃn, C
Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish.
J Biol Chem
279
26627-34
2004
amphibia, Arthropoda, Chondrichthyes, Escherichia coli, Homo sapiens, Mammalia, Mus musculus
Kijimoto, T; Watanabe, M; Fujimura, K; Nakazawa, M; Murakami, Y; Kuratani, S; Kohara, Y; Gojobori, T; Okada, N
cimp1, a novel astacin family metalloproteinase gene from East African cichlids, is differentially expressed between species during growth.
Mol Biol Evol
22
1649-60
2005
African cichlids, cichlidae, Metazoa, Haplochromis, Victoria
Williamson, AL; Lustigman, S; Oksov, Y; Deumic, V; Plieskatt, J; Mendez, S; Zhan, B; Bottazzi, ME; Hotez, PJ; Loukas, A
Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration.
Infect Immun
74
961-7
2006
Ancylostoma caninum
Feng, J; Zhan, B; Liu, Y; Liu, S; Williamson, A; Goud, G; Loukas, A; Hotez, P
Molecular cloning and characterization of Ac-MTP-2, an astacin-like metalloprotease released by adult Ancylostoma caninum.
Mol Biochem Parasitol
152
132-8
2007
Ancylostoma caninum, Ancylostomatoidea, Nematoda, Caenorhabditis elegans, Chelator
da Silveira, RB; Wille, AC; Chaim, OM; Appel, MH; Silva, DT; Franco, CR; Toma, L; Mangili, OC; Gremski, W; Dietrich, CP; Nader, HB; Veiga, SS
Identification, cloning, expression and functional characterization of an astacin-like metalloprotease toxin from Loxosceles intermedia (brown spider) venom.
Biochem J
406
355-63
2007
Loxosceles intermedia, animal, Araneae, Chelator
Sharma, OP; Agrawal, S; Kumar, MS
Physicochemical properties of the modeled structure of astacin metalloprotease moulting enzyme NAS-36 and mapping the druggable allosteric space of Heamonchus contortus, Brugia malayi and Ceanorhabditis elegans via molecular dynamics simulation.
Interdiscip Sci
5
312-23
2013
animal, Brugia malayi, Caenorhabditis elegans, Haemonchus contortus, Nematoda, Nematodes
Xiong, B; Zhao, Y; Beall, S; Sadusky, AB; Dean, J
A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice.
PLoS Genet
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e1006580
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Mus sp., Mus musculus
Dai, X; Lu, Y; Zhang, M; Miao, Y; Zhou, C; Cui, Z; Xiong, B
Melatonin improves the fertilization ability of post-ovulatory aged mouse oocytes by stabilizing ovastacin and Juno to promote sperm binding and fusion.
Hum Reprod
32
598-606
2017
Mus musculus
Di, Q; Lin, Q; Huang, Z; Chi, Y; Chen, X; Zhang, W; Zhang, Y
Zebrafish nephrosin helps host defence against Escherichia coli infection.
Open Biol
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Escherichia coli, Danio rerio
Quesada, V; Sánchez, LM; Álvarez, J; López-Otín, C
Withdrawal: Identification and characterization of human and mouse ovastacin: A novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish.
J Biol Chem
294
1432
2019
Arthropoda, Chondrichthyes, amphibia, Homo sapiens, Mus musculus
Guevara, T; Körschgen, H; Cuppari, A; Schmitz, C; Kuske, M; Yiallouros, I; Floehr, J; Jahnen-Dechent, W; Stöcker, W; Gomis-Rüth, FX
The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases.
Sci Rep
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14683
2019
Homo sapiens, Astacoidea, Mus musculus
Ziegler, B; Yiallouros, I; Trageser, B; Kumar, S; Mercker, M; Kling, S; Fath, M; Warnken, U; Schnölzer, M; Holstein, TW; Hartl, M; Marciniak-Czochra, A; Stetefeld, J; Stöcker, W; Özbek, S
The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra.
BMC Biol
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2021
Hydra
Shibata, Y; Iwamatsu, T; Oba, Y; Kobayashi, D; Tanaka, M; Nagahama, Y; Suzuki, N; Yoshikuni, M
Identification and cDNA cloning of alveolin, an extracellular metalloproteinase, which induces chorion hardening of medaka (Oryzias latipes) eggs upon fertilization.
J Biol Chem
275
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Oryzias latipes
Bode, W; Kress, LF; Meyer, EF; Gomis-Rüth, FX
The crystal structure of adamalysin II, a zinc-endopeptidase from the snake venom of the eastern diamondback rattlesnake Crotalus adamanteus.
Braz J Med Biol Res
27
2049-68
1994
Ursidae, Crotalus adamanteus, snake
Gomis-Rüth, FX; Kress, LF; Bode, W
First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases.
EMBO J
12
4151-7
1993
Ursidae
Jiang, W; Kumar, JM; Matters, GL; Bond, JS
Structure of the mouse metalloprotease meprin beta gene (Mep1b): alternative splicing in cancer cells.
Gene
248
77-87
2000
Saccharomyces cerevisiae
Hahn, D; Pischitzis, A; Roesmann, S; Hansen, MK; Leuenberger, B; Luginbuehl, U; Sterchi, EE
Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease.
J Biol Chem
278
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2003
Homo sapiens, Lamina
Yasumasu, S; Shimada, H; Inohaya, K; Yamazaki, K; Iuchi, I; Yasumasu, I; Yamagami, K
Different exon-intron organizations of the genes for two astacin-like proteases, high choriolytic enzyme (choriolysin H) and low choriolytic enzyme (choriolysin L), the constituents of the fish hatching enzyme.
Eur J Biochem
237
752-8
1996
Oryzias latipes, Chondrichthyes, Felis catus
Nagasawa, T; Kawaguchi, M; Sano, K; Yasumasu, S
Sturgeon hatching enzyme and the mechanism of egg envelope digestion: Insight into changes in the mechanism of egg envelope digestion during the evolution of ray-finned fish.
J Exp Zool B Mol Dev Evol
324
720-32
2015
Acipenser sturio, Chondrichthyes, Actinopterygii, Acipenseridae, amphibia, Xenopus, Teleostei, Acipenser ruthenus x Huso huso
Guncheva, M; Dolashka-Angelova, P; Stambolieva, N
Arylamidase activity of neutral proteinase from Saccharomonospora canescens. Comparison with other Zn-proteinases that exhibit the same activity.
Biochim Biophys Acta
1597
335-8
2002
Saccharomonospora
Tiraboschi, G; Jullian, N; Thery, V; Antonczak, S; Fournie-Zaluski, MC; Roques, BP
A three-dimensional construction of the active site (region 507-749) of human neutral endopeptidase (EC.3.4.24.11).
Protein Eng
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1999
Homo sapiens
Lovejoy, B; Hassell, AM; Luther, MA; Weigl, D; Jordan, SR
Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself.
Biochemistry
33
8207-17
1994
Astacoidea
Pan, T; Gröger, H; Schmid, V; Spring, J
A toxin homology domain in an astacin-like metalloproteinase of the jellyfish Podocoryne carnea with a dual role in digestion and development.
Dev Genes Evol
208
259-66
1998
Anemone, animal, Astacoidea, Cnidaria, Homo sapiens, Hydra vulgaris, Podocoryna carnea
Yokozawa, Y; Tamai, H; Tatewaki, S; Tajima, T; Tsuchiya, T; Kanzawa, N
Cloning and biochemical characterization of astacin-like squid metalloprotease.
J Biochem (Tokyo)
132
751-8
2002
Doryteuthis pealeii
Davis, MW; Birnie, AJ; Chan, AC; Page, AP; Jorgensen, EM
A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans.
Development
131
6001-8
2004
Caenorhabditis elegans, Nematoda, Haemonchus, Nematodes
Kanzawa, N; Tatewaki, S; Watanabe, R; Kunihisa, I; Iwahashi, H; Nakamura, K; Tsuchiya, T
Expression and tissue distribution of astacin-like squid metalloprotease (ALSM).
Comp Biochem Physiol B Biochem Mol Biol
142
153-63
2005
Doryteuthis pealeii
Xiong, X; Chen, L; Li, Y; Xie, L; Zhang, R
Pf-ALMP, a novel astacin-like metalloproteinase with cysteine arrays, is abundant in hemocytes of pearl oyster Pinctada fucata.
Biochim Biophys Acta
1759
526-34
0
Pinctada fucata
Borchert, N; Becker-Pauly, C; Wagner, A; Fischer, P; Stöcker, W; Brattig, NW
Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus.
Microbes Infect
9
498-506
2007
Onchocerca volvulus, Filaria, Nematoda, Caenorhabditis, Homo sapiens, Ancylostoma
Kanzawa, N; Ogawa, T; Asakura, M; Okiyama, K; Honda, M; Tsuchiya, T
Comparative expression and tissue distribution analyses of astacin-like squid metalloprotease in squid and cuttlefish.
Zoolog Sci
25
14-21
2008
Doryteuthis pealeii, Sepiidae, Sepia esculenta
Trevisan-Silva, D; Bednaski, AV; Gremski, LH; Chaim, OM; Veiga, SS; Senff-Ribeiro, A
Differential metalloprotease content and activity of three Loxosceles spider venoms revealed using two-dimensional electrophoresis approaches.
Toxicon
76C
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2013
Loxosceles intermedia, animal
Tabrizchi, R; Triggle, CR
Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin.
J Pharmacol Exp Ther
253
272-6
1990
Metazoa
Frank, C; Longo, R; Sagratella, S
Pertussis toxin prevents neomycin-induced calcium-dependent electrophysiological effects in rat hippocampal slices.
Gen Pharmacol
25
957-61
1994
Metazoa
Kozlowski, DJ; Gagnon, ML; Marchant, JK; Reynolds, SD; Angerer, LM; Angerer, RC
Characterization of a SpAN promoter sufficient to mediate correct spatial regulation along the animal-vegetal axis of the sea urchin embryo.
Dev Biol
176
95-107
1996
Drosophila
Inohaya, K; Yasumasu, S; Araki, K; Naruse, K; Yamazaki, K; Yasumasu, I; Iuchi, I; Yamagami, K
Species-dependent migration of fish hatching gland cells that express astacin-like proteases in common [corrected]
Dev Growth Differ
39
191-7
1997
Chondrichthyes, Danio rerio, Oncorhynchus masou, Oryzias latipes
Jiang, W; Beatty, BG
Identification and localization of MEP1A-like sequences (MEP1AL1-4) in the human genome.
Biochem Biophys Res Commun
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163-8
1999
Homo sapiens
Sonenshine, DE; Bissinger, BW; Egekwu, N; Donohue, KV; Khalil, SM; Roe, RM
First transcriptome of the testis-vas deferens-male accessory gland and proteome of the spermatophore from Dermacentor variabilis (Acari: Ixodidae).
PLoS One
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e24711
2011
Drosophila, Hexapoda
Huang, L; Wang, Z; Yu, N; Li, J; Liu, Z
Toxin diversity revealed by the venom gland transcriptome of Pardosa pseudoannulata, a natural enemy of several insect pests.
Comp Biochem Physiol Part D Genomics Proteomics
28
172-182
2018
Pardosa pseudoannulata
Stöcker, W; Breit, S; Sottrup-Jensen, L; Zwilling, R
alpha2-Macroglobulin from hemolymph of the freshwater crayfish Astacus astacus.
Comp Biochem Physiol B
98
501-9
1991
Astacoidea, Astacus
Milhiet, PE; Corbeil, D; Simon, V; Kenny, AJ; Crine, P; Boileau, G
Expression of rat endopeptidase-24.18 in COS-1 cells: membrane topology and activity.
Biochem J
300 ( Pt 1)
37-43
1994
Rodentia
Corbeil, D; Milhiet, PE; Simon, V; Ingram, J; Kenny, AJ; Boileau, G; Crine, P
Rat endopeptidase-24.18 alpha subunit is secreted into the culture medium as a zymogen when expressed by COS-1 cells.
FEBS Lett
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361-6
1993
Mus musculus, Rattus
Dholey, Y; Chaudhuri, A; Chakraborty, SS
An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A.
J Biomol Struct Dyn
1-13
2019
Homo sapiens
Nguyen, T; Jamal, J; Shimell, MJ; Arora, K; O'Connor, MB
Characterization of tolloid-related-1: a BMP-1-like product that is required during larval and pupal stages of Drosophila development.
Dev Biol
166
569-86
1994
Astacoidea
Gomez Gallego, S; Loukas, A; Slade, RW; Neva, FA; Varatharajalu, R; Nutman, TB; Brindley, PJ
Identification of an astacin-like metallo-proteinase transcript from the infective larvae of Strongyloides stercoralis.
Parasitol Int
54
123-33
2005
Astacoidea, Astacus astacus, Caenorhabditis elegans, Drosophila, Echinoidea, Homo sapiens, Nematoda, Strongyloides, Strongyloides stercoralis
Rezende Júnior, L; Cordeiro, MN; Oliveira, EB; Diniz, CR
Isolation of neurotoxic peptides from the venom of the 'armed' spider Phoneutria nigriventer.
Toxicon
29
1225-33
1991
Mus musculus, Mus sp.
Jolkkonen, M; van Giersbergen, PL; Hellman, U; Wernstedt, C; Karlsson, E
A toxin from the green mamba Dendroaspis angusticeps: amino acid sequence and selectivity for muscarinic m4 receptors.
FEBS Lett
352
91-4
1994
Dendroaspis angusticeps, snake
Utkin, YN; Krivoshein, AV; Davydov, VL; Kasheverov, IE; Franke, P; Maslennikov, IV; Arseniev, AS; Hucho, F; Tsetlin, VI
Labeling of Torpedo californica nicotinic acetylcholine receptor subunits by cobratoxin derivatives with photoactivatable groups of different chemical nature at Lys23.
Eur J Biochem
253
229-35
1998
Naja naja, Naja siamensis
Saetang, T; Suttijitpaisal, P; Ratanabanangkoon, K
Preparations of toxic components from Naja kaouthia venom by selective heat denaturation.
J Nat Toxins
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37-44
1998
Naja kaouthia, Oryctolagus cuniculus
Mao, NC; Steingrimsson, E; DuHadaway, J; Wasserman, W; Ruiz, JC; Copeland, NG; Jenkins, NA; Prendergast, GC
The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2.
Genomics
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Mus musculus
Karlsson, E; Jolkkonen, M; Mulugeta, E; Onali, P; Adem, A
Snake toxins with high selectivity for subtypes of muscarinic acetylcholine receptors.
Biochimie
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793-806
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Hippocampus, Rattus
Sarras, MP; Yan, L; Leontovich, A; Zhang, JS
Structure, expression, and developmental function of early divergent forms of metalloproteinases in hydra.
Cell Res
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163-76
2002
Hydra, Cnidaria, Phyla, animal
Song, HD; Sun, XJ; Deng, M; Zhang, GW; Zhou, Y; Wu, XY; Sheng, Y; Chen, Y; Ruan, Z; Jiang, CL; Fan, HY; Zon, LI; Kanki, JP; Liu, TX; Look, AT; Chen, Z
Hematopoietic gene expression profile in zebrafish kidney marrow.
Proc Natl Acad Sci U S A
101
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2004
Danio rerio
De Maere, V; Vercauteren, I; Geldhof, P; Gevaert, K; Vercruysse, J; Claerebout, E
Molecular analysis of astacin-like metalloproteases of Ostertagia ostertagi.
Parasitology
130
89-98
2005
Ostertagia ostertagi, Nematoda, Ostertagia, Bos taurus, Ancylostoma caninum
Novelli, J; Page, AP; Hodgkin, J
The C terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly.
Genetics
172
2253-67
2006
Caenorhabditis elegans
Dubinion, JH; Mi, Z; Jackson, EK
Role of renal sympathetic nerves in regulating renovascular responses to angiotensin II in spontaneously hypertensive rats.
J Pharmacol Exp Ther
317
1330-6
2006
Metazoa
Miao, F; Lu, D; Li, Y; Zeng, M
Characterization of astaxanthin esters in Haematococcus pluvialis by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
Anal Biochem
352
176-81
2006
Haematococcus lacustris
Harlin-Cognato, A; Hoffman, EA; Jones, AG
Gene cooption without duplication during the evolution of a male-pregnancy gene in pipefish.
Proc Natl Acad Sci U S A
103
19407-12
2006
Leptonotus elevatus, Actinopterygii
Yoshida, A; Nagayasu, E; Nishimaki, A; Sawaguchi, A; Yanagawa, S; Maruyama, H
Transcripts analysis of infective larvae of an intestinal nematode, Strongyloides venezuelensis.
Parasitol Int
60
75-83
2011
Strongyloides stercoralis, Nematoda, Strongyloides venezuelensis, Strongyloides, Nematodes, Sabicea venezuelensis
Varatharajalu, R; Parandaman, V; Ndao, M; Andersen, JF; Neva, FA
Strongyloides stercoralis excretory/secretory protein strongylastacin specifically recognized by IgE antibodies in infected human sera.
Microbiol Immunol
55
115-22
2011
Astacus, Astacoidea
Li, Y; Paik, YK
A potential role for fatty acid biosynthesis genes during molting and cuticle formation in Caenorhabditis elegans.
BMB Rep
44
285-90
2011
Caenorhabditis elegans
Avella, MA; Xiong, B; Dean, J
The molecular basis of gamete recognition in mice and humans.
Mol Hum Reprod
2013
Homo sapiens, Mus sp., Mus musculus
Yong, HS; Eamsobhana, P; Lim, PE; Razali, R; Aziz, FA; Rosli, NS; Poole-Johnson, J; Anwar, A
Draft genome of neurotropic nematode parasite Angiostrongylus cantonensis, causative agent of human eosinophilic meningitis.
Acta Trop
148
51-7
2015
Nematoda
Fotopoulos, P; Kim, J; Hyun, M; Qamari, W; Lee, I; You, YJ
DPY-17 and MUA-3 Interact for Connective Tissue-Like Tissue Integrity in Caenorhabditis elegans: A Model for Marfan Syndrome.
G3 (Bethesda)
5
1371-8
2015
Mammalia
Dai, X; Zhang, M; Lu, Y; Miao, Y; Zhou, C; Sun, S; Xiong, B
Melamine Impairs Female Fertility via Suppressing Protein Level of Juno in Mouse Eggs.
PLoS One
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e0144248
2015
Mus sp.
Fuzita, FJ; Pinkse, MW; Patane, JS; Verhaert, PD; Lopes, AR
High throughput techniques to reveal the molecular physiology and evolution of digestion in spiders.
BMC Genomics
17
716
2016
Araneae
Baskaran, P; Jaleta, TG; Streit, A; Rödelsperger, C
Duplications and positive selection drive the evolution of parasitism associated gene families in the nematode Strongyloides papillosus.
Genome Biol Evol
2017
Strongyloides papillosus, Strongyloididae, Ovis aries, Nematodes
Muraina, IA; Maret, W; Bury, NR; Hogstrand, C
Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a.
Biochem Biophys Res Commun
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698-705
2020
Homo sapiens
Davis, SW; Smith, WC
Expression cloning in ascidians: isolation of a novel member of the asctacin protease family.
Dev Genes Evol
212
81-6
2002
Xenopus, Chordata, Ciona intestinalis, vertebrata
Burkart, AD; Xiong, B; Baibakov, B; Jiménez-Movilla, M; Dean, J
Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy.
J Cell Biol
197
37-44
2012
Mus musculus, Mus sp.
Hahn, D; Lottaz, D; Sterchi, EE
C-cytosolic and transmembrane domains of the N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase alpha subunit (human meprin alpha) are essential for its retention in the endoplasmic reticulum and C-terminal processing.
Eur J Biochem
247
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1997
Homo sapiens
Pischitzis, A; Hahn, D; Leuenberger, B; Sterchi, EE
N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase beta (human meprinbeta). A 13-amino-acid sequence is required for proteolyticprocessing and subsequent secretion.
Eur J Biochem
261
421-9
1999
Rodentia
Red Eagle, AR; Hanson, RL; Jiang, W; Han, X; Matters, GL; Imperatore, G; Knowler, WC; Bond, JS
Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians.
Hum Genet
118
12-22
2005
Homo sapiens
Marín, I
Origin and Diversification of Meprin Proteases.
PLoS One
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e0135924
2015
vertebrata, Chondrichthyes, Callorhinchus milii, Homo sapiens, Poecilia formosa
Karmilin, K; Schmitz, C; Kuske, M; Körschgen, H; Olf, M; Meyer, K; Hildebrand, A; Felten, M; Fridrich, S; Yiallouros, I; Becker-Pauly, C; Weiskirchen, R; Jahnen-Dechent, W; Floehr, J; Stöcker, W
Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases.
Sci Rep
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546
2019
Mus sp.
Childs, SR; O'Connor, MB
Two domains of the tolloid protein contribute to its unusual genetic interaction with decapentaplegic.
Dev Biol
162
209-20
1994
Homo sapiens
Sarras, MP
BMP-1 and the astacin family of metalloproteinases: a potential link between the extracellular matrix, growth factors and pattern formation.
Bioessays
18
439-42
1996
Homo sapiens
Stöcker, W; Sauer, B; Zwilling, R
Kinetics of nitroanilide cleavage by astacin.
Biol Chem Hoppe Seyler
372
385-92
1991
Astacus astacus, Astacoidea, Homo sapiens
Bond, JS; Beynon, RJ
The astacin family of metalloendopeptidases.
Protein Sci
4
1247-61
1995
Astacoidea, animal, Hydra, Homo sapiens, snake
Geier, G; Jacob, E; Stöcker, W; Zwilling, R
Genomic organization of the zinc-endopeptidase astacin.
Arch Biochem Biophys
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Astacoidea, Chondrichthyes, Homo sapiens, Drosophila
Johnson, GD; Bond, JS
Activation mechanism of meprins, members of the astacin metalloendopeptidase family.
J Biol Chem
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1997
Homo sapiens, Mus musculus
Olianas, MC; Ingianni, A; Maullu, C; Adem, A; Karlsson, E; Onali, P
Selectivity profile of muscarinic toxin 3 in functional assays of cloned and native receptors.
J Pharmacol Exp Ther
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164-70
1999
Cricetulus griseus, Homo sapiens
Sterchi, EE; Stöcker, W; Bond, JS
Meprins, membrane-bound and secreted astacin metalloproteinases.
Mol Aspects Med
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309-28
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Caenorhabditis elegans, Astacoidea, Echinoidea, Cyprinus carpio, Homo sapiens, Mus musculus, Bacteria
Park, JO; Pan, J; Möhrlen, F; Schupp, MO; Johnsen, R; Baillie, DL; Zapf, R; Moerman, DG; Hutter, H
Characterization of the astacin family of metalloproteases in C. elegans.
BMC Dev Biol
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2010
Nematodes, Bacteria, Caenorhabditis elegans, Metazoa
France, DJ; Stepek, G; Houston, DR; Williams, L; McCormack, G; Walkinshaw, MD; Page, AP
Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31.
Bioorg Med Chem Lett
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5752-5
2015
Nematoda, Brugia malayi, Homo sapiens, Ovis aries, Metazoa, Teladorsagia circumcincta, Nematodes
Körschgen, H; Kuske, M; Karmilin, K; Yiallouros, I; Balbach, M; Floehr, J; Wachten, D; Jahnen-Dechent, W; Stöcker, W
Intracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida.
Mol Hum Reprod
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607-616
2017
Homo sapiens, Mus sp.
Cuppari, A; Körschgen, H; Fahrenkamp, D; Schmitz, C; Guevara, T; Karmilin, K; Kuske, M; Olf, M; Dietzel, E; Yiallouros, I; de Sanctis, D; Goulas, T; Weiskirchen, R; Jahnen-Dechent, W; Floehr, J; Stoecker, W; Jovine, L; Gomis-Rüth, FX
Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition.
IUCrJ
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317-330
2019
Mammalia
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Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor.
Science
263
375-7
1994
Astacoidea
Wardle, FC; Angerer, LM; Angerer, RC; Dale, L
Regulation of BMP signaling by the BMP1/TLD-related metalloprotease, SpAN.
Dev Biol
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63-72
1999
Echinoidea, Xenopus
Chaudhuri, A; Hudait, N; Chakraborty, SS
Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease.
Comput Biol Chem
80
292-306
2019
Homo sapiens
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Hysteretic behaviour of citrate synthase. Site-directed limited proteolysis.
Eur J Biochem
143
205-12
1984
Astacus
Ng, M; Auld, DS
A fluorescent oligopeptide energy transfer assay with broad applications for neutral proteases.
Anal Biochem
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50-6
1989
Astacus
Yiallouros, I; Kappelhoff, R; Schilling, O; Wegmann, F; Helms, MW; Auge, A; Brachtendorf, G; Berkhoff, EG; Beermann, B; Hinz, HJ; König, S; Peter-Katalinic, J; Stöcker, W
Activation mechanism of pro-astacin: role of the pro-peptide, tryptic and autoproteolytic cleavage and importance of precise amino-terminal processing.
J Mol Biol
324
237-46
2002
Astacus, Astacoidea
Mac Sweeney, A; Gil-Parrado, S; Vinzenz, D; Bernardi, A; Hein, A; Bodendorf, U; Erbel, P; Logel, C; Gerhartz, B
Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.
J Mol Biol
384
228-39
2008
Homo sapiens
Martínez-Glez, V; Valencia, M; Caparrós-Martín, JA; Aglan, M; Temtamy, S; Tenorio, J; Pulido, V; Lindert, U; Rohrbach, M; Eyre, D; Giunta, C; Lapunzina, P; Ruiz-Perez, VL
Identification of a mutation causing deficient BMP1/mTLD proteolytic activity in autosomal recessive osteogenesis imperfecta.
Hum Mutat
33
343-50
2012
Homo sapiens
Floehr, J; Dietzel, E; Neulen, J; Rösing, B; Weissenborn, U; Jahnen-Dechent, W
Association of high fetuin-B concentrations in serum with fertilization rate in IVF: a cross-sectional pilot study.
Hum Reprod
31
630-7
2016
Mus sp.
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Inhibitors of BMP-1/tolloid-like proteinases: efficacy, selectivity and cellular toxicity.
FEBS Open Bio
8
2011-2021
2018
Homo sapiens
Stöcker, W; Grams, F; Baumann, U; Reinemer, P; Gomis-Rüth, FX; McKay, DB; Bode, W
The metzincins--topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases.
Protein Sci
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823-40
1995
Astacoidea, Erwinia, Homo sapiens, Pseudomonas aeruginosa, Serratia, snake
Jiang, W; Bond, JS
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FEBS Lett
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110-4
1992
Serratia, snake
Clark, TG; Conway, SJ; Scott, IC; Labosky, PA; Winnier, G; Bundy, J; Hogan, BL; Greenspan, DS
The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart.
Development
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1999
Drosophila
Ge, G; Greenspan, DS
Developmental roles of the BMP1/TLD metalloproteinases.
Birth Defects Res C Embryo Today
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47-68
2006
Homo sapiens, Hydra
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Interaction surfaces of neurotoxins and acetylcholine receptor.
Toxicon
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1982
Naja oxiana, Naja naja, Naja siamensis
Yiallouros, I; Grosse Berkhoff, E; Stöcker, W
The roles of Glu93 and Tyr149 in astacin-like zinc peptidases.
FEBS Lett
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224-8
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Escherichia coli
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Astacin-like metalloproteases are a gene family of toxins present in the venom of different species of the brown spider (genus Loxosceles).
Biochimie
92
21-32
2010
Loxosceles, Loxosceles gaucho, Loxosceles laeta, Loxosceles intermedia, Araneae, Chelator
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Metal preferences of zinc-binding motif on metalloproteases.
J Amino Acids
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Lactococcus lactis
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Two tarantula venom peptides as potent and differential Na(V) channels blockers.
Toxicon
77
58-67
2014
Grammostola rosea
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Kv4 channels underlie A-currents with highly variable inactivation time courses but homogeneous other gating properties in the nucleus tractus solitarii.
Pflugers Arch
2014
Androctonus mauritanicus mauritanicus, Anemone
Floehr, J; Dietzel, E; Schmitz, C; Chappell, A; Jahnen-Dechent, W
Down-regulation of the liver-derived plasma protein fetuin-B mediates reversible female infertility.
Mol Hum Reprod
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34-44
2017
Mus sp.
Chakraborty, T; Mohapatra, S; Tobayama, M; Ohta, K; Ryu, YW; Kazeto, Y; Ohta, K; Zhou, L; Nagahama, Y; Matsubara, T
Hatching enzymes disrupt aberrant gonadal degeneration by the autophagy/apoptosis cell fate decision.
Sci Rep
7
3183
2017
Engraulis japonicus
Zhang, M; Miao, Y; Chen, Q; Cai, M; Dong, W; Dai, X; Lu, Y; Zhou, C; Cui, Z; Xiong, B
BaP exposure causes oocyte meiotic arrest and fertilization failure to weaken female fertility.
FASEB J
2017
Mus musculus
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