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Disease on EC 3.4.24.18 - meprin A

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats.
ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A.
Meprin ? Activity Modulates the beta Catalytic Subunit of Protein Kinase A (PKA C?) in Ischemia/Reperfusion-Induced Acute Kidney Injury.
Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge.
Meprin A metalloproteinase and its role in acute kidney injury.
Role of meprin A in renal tubular epithelial cell injury.
The role of meprin A in the pathogenesis of acute renal failure.
Acute Lung Injury
Inhibition of Meprins Reduces Pulmonary Edema in LPS-Induced Acute Lung Damage.
Adenocarcinoma, Mucinous
Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries.
Alopecia
Syndecan-1 shedding by meprin ? impairs keratinocyte adhesion and differentiation in hyperkeratosis.
Alzheimer Disease
Expression, purification and initial characterization of human meprin ? from Pichia pastoris.
Shedding light on designing potential meprin ? inhibitors through ligand-based robust validated computational approaches: A proposal to chemists!
Tetraspanin 8 is an interactor of the metalloprotease meprin ? within tetraspanin-enriched microdomains.
The Metalloprotease Meprin ? Is an Alternative ?-Secretase of APP.
Amyotrophic Lateral Sclerosis
Calcium negatively regulates meprin ? activity and attenuates substrate cleavage.
Arthritis
Elevated synovial tissue concentration of the common acute lymphoblastic leukaemia antigen (CALLA)-associated neutral endopeptidase (3.4.24.11) in human chronic arthritis.
Arthritis, Rheumatoid
Neutral endopeptidase (3.4.24.11) in plasma and synovial fluid of patients with rheumatoid arthritis. A marker of disease activity or a regulator of pain and inflammation?
Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B.
Astrocytoma
Hydrolysis of atrial and brain natriuretic peptides by the human astrocytoma clone D384 and the neuroblastoma line SH-SY5Y.
Atherosclerosis
A meprin inhibitor suppresses atherosclerotic plaque formation in ApoE(-/-) mice.
Potential role of calcifying nanoparticles in the etiology of multiple sclerosis.
Vascular neutral endopeptidase inhibition improves endothelial function and reduces intimal hyperplasia.
Bone Resorption
Inhibition of bone resorption in vitro by human enkephalinase (EC 3.4.24.11), a neutral metalloendopeptidase.
Breast Neoplasms
Expression and regulation of the meprin beta gene in human cancer cells.
Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.
Bronchial Hyperreactivity
Correlation between neutral endopetidase (NEP) 3.4.24.11 in serum and the degree of the bronchial hyperreactivity.
Carcinoma
A novel meprin beta' mRNA in mouse embryonal and human colon carcinoma cells.
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin ? and promotes transendothelial cell migration.
Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro.
Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries.
Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma.
Structure of the mouse metalloprotease meprin beta gene (Mep1b): alternative splicing in cancer cells.
Carcinoma, Hepatocellular
High concentration of neutral endopeptidase (enkephalinase E.C. 3.4.24.11) in a malignant tumor: rat hepatoma 3924A.
MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma.
Carcinoma, Lewis Lung
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin ? and promotes transendothelial cell migration.
Cardiomegaly
Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation.
Cardiovascular Diseases
B-Type Natriuretic Peptide 8-32 (BNP 8-32), Which is Produced From Mature BNP 1-32 by the Metalloprotease Meprin A, has Reduced Bioactivity.
Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2.
Colitis
Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease.
Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P.
TNF-?-induced down-regulation of CDX2 suppresses MEP1A expression in colitis.
Colitis, Ulcerative
MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease.
TNF-?-induced down-regulation of CDX2 suppresses MEP1A expression in colitis.
Colonic Neoplasms
Expression and regulation of the meprin beta gene in human cancer cells.
Meprin B: transcriptional and posttranscriptional regulation of the meprin beta metalloproteinase subunit in human and mouse cancer cells.
Multistage vector delivery of sulindac and silymarin for prevention of colon cancer.
Colorectal Neoplasms
Activation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating system.
Erratum: Meprin ? combined with CEA and CA19-9 improves prognostic prediction for surgically treated colorectal cancer patients.
Meprin ? combined with CEA and CA19-9 improves prognostic prediction for surgically treated colorectal cancer patients.
Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma.
Role of meprin metalloproteases in metastasis and tumor microenvironment.
Cough
Evidence for substance P as an endogenous substance causing cough in guinea pigs.
Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs.
Cystic Fibrosis
Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.
Dehydration
Combined effects of water stress and high temperature on photosynthesis, nitrogen metabolism and lipid peroxidation of a perennial grass Leymus chinensis.
Diabetes Mellitus, Type 1
LC-MS-based metabolomics analysis to identify meprin ?-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury.
Meprin ? metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy.
Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes.
Diabetic Nephropathies
Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities.
LC-MS-based metabolomics analysis to identify meprin ?-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury.
Meprin ? metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy.
Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians.
Meprin-alpha in chronic diabetic nephropathy: interaction with the renin-angiotensin axis.
Targeted disruption of the meprin beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles.
Undiagnosed Kidney Injury in Uninsured and Underinsured Diabetic African American Men and Putative Role of Meprin Metalloproteases in Diabetic Nephropathy.
Urinary meprin-alpha: a potential marker of diabetic nephropathy.
Endometrial Neoplasms
The cancer-associated meprin ? variant G32R provides an additional activation site and promotes cancer cell invasion.
Endotoxemia
Reduced Expression of Extracellular Matrix Proteins in the Heart and Kidneys of Rats with Endotoxemia under the Effect of Actinonin.
Enteritis
Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A.
Essential Hypertension
Chronic inhibition of endopeptidase 24.11 in essential hypertension: evidence for enhanced atrial natriuretic peptide and angiotensin II.
Inhibition of endopeptidase EC 3.4.24.11 by candoxatril lowered blood pressure and increased urinary but not plasma atrial natriuretic peptide in essential hypertension.
Exocrine Pancreatic Insufficiency
Non-pancreatic hydrolysis of N-benzoyl-l-tyrosyl-p-aminobenzoic acid (PABA-peptide) in the human small intestine.
Familial Primary Pulmonary Hypertension
Meprin ?, a novel mediator of vascular remodelling underlying pulmonary hypertension.
Gallstones
Evidence for oxidative stress in the gall bladder mucosa of gall stone patients.
Gastrointestinal Neoplasms
Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries.
Glioblastoma
Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.
Glomerulonephritis
Downregulated expression in high IgA (HIGA) mice and the renal protective role of meprinbeta.
Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis.
Glomerulonephritis, Membranous
Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis.
Heart Failure
Effects of alatriopril, a mixed inhibitor of atriopeptidase and angiotensin I-converting enzyme, on cardiac hypertrophy and hormonal responses in rats with myocardial infarction. Comparison with captopril.
Inhibition of neutral endopeptidase 3.4.24.11 in conscious dogs with pacing induced heart failure.
Mercaptoacyl dipeptides as orally active dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase.
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.
Potentiation of brain natriuretic peptides by SQ 28,603, an inhibitor of neutral endopeptidase 3.4.24.11, in monkeys and rats.
Pulmonary and renal neutral endopeptidase EC 3.4.24.11 in rats with experimental heart failure.
Systemic hemodynamics, renal function and hormonal levels during inhibition of neutral endopeptidase 3.4.24.11 and angiotensin-converting enzyme in conscious dogs with pacing-induced heart failure.
The atriopeptidase inhibitor UK 69,578 increases atrial natriuretic factor and causes a natriuresis in normal humans.
Hydronephrosis
Expression of subunits of the metalloendopeptidase meprin in renal cortex in experimental hydronephrosis.
Hypertension
Meprin ?, a novel mediator of vascular remodelling underlying pulmonary hypertension.
Mercaptoacyl dipeptides as orally active dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase.
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.
Potentiation of brain natriuretic peptides by SQ 28,603, an inhibitor of neutral endopeptidase 3.4.24.11, in monkeys and rats.
The atriopeptidase inhibitor UK 69,578 increases atrial natriuretic factor and causes a natriuresis in normal humans.
Hypertension, Pulmonary
Meprin ?, a novel mediator of vascular remodelling underlying pulmonary hypertension.
Neutral endopeptidase 24.11 inhibition reduces pulmonary vascular remodeling in rats exposed to chronic hypoxia.
Hypertrophy, Right Ventricular
Neutral endopeptidase 24.11 inhibition reduces pulmonary vascular remodeling in rats exposed to chronic hypoxia.
Infections
Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge.
Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer.
Role of meprin metalloproteases in metastasis and tumor microenvironment.
Inflammatory Bowel Diseases
An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A.
Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease.
Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells.
Fetuin-A and Cystatin C Are Endogenous Inhibitors of Human Meprin Metalloproteases.
First insight into structure-activity relationships of selective meprin ? inhibitors.
Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities.
MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease.
Meprin metalloproteases inactivate interleukin 6.
Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis.
Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease.
Post-transcriptional regulation of meprin ? by the RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP).
Shedding light on designing potential meprin ? inhibitors through ligand-based robust validated computational approaches: A proposal to chemists!
Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin ? Inhibitors.
Insulin Resistance
Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome.
Kidney Diseases
The glomerular proteome in a model of chronic kidney disease.
Leukemia
CD10 and CD44 genes of leukemic cells and malignant cell lines show no evidence of transformation-related alterations.
Liver Diseases
MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma.
Liver Neoplasms
MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma.
Lung Neoplasms
Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin ? but alter cell migration in vitro.
Effects of recombinant neutral endopeptidase (EC 3.4.24.11) on the growth of lung cancer cell lines in vitro and in vivo.
Lymphoma, Non-Hodgkin
Thiorphan stimulates clonal growth of GM-CFU in short-term cultures of bone marrow from a healthy donor and from patients with non-Hodgkin lymphoma.
meprin a deficiency
Certain mouse strains are deficient in a kidney brush-border metallo-endopeptidase activity.
Deficiency of a kidney metalloproteinase activity in inbred mouse strains.
Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells.
Distinct contributions of meprins to skin regeneration after injury - Meprin ? a physiological processer of pro-collagen VII.
Mep-1 gene controlling a kidney metalloendopeptidase is linked to the major histocompatibility complex in mice.
Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation.
Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes.
Meprin-? (Mep1A) enhances TNF-? secretion by mast cells and aggravates abdominal aortic aneurysms.
Migraine Disorders
Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG.
Multiple Sclerosis
Potential role of calcifying nanoparticles in the etiology of multiple sclerosis.
Myoclonic Epilepsy, Juvenile
Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG.
Neoplasm Metastasis
Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries.
Meprin ? combined with CEA and CA19-9 improves prognostic prediction for surgically treated colorectal cancer patients.
Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma.
Role of meprin metalloproteases in metastasis and tumor microenvironment.
Shedding light on designing potential meprin ? inhibitors through ligand-based robust validated computational approaches: A proposal to chemists!
Neoplasms
Activation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating system.
An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A.
Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation.
Changes in cell-surface peptidase activity in papillary renal cell carcinoma.
Discovery and Optimization of Selective Inhibitors of Meprin ? (Part I).
Discovery and Optimization of Selective Inhibitors of Meprin ? (Part II).
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin ? and promotes transendothelial cell migration.
Expression and regulation of the meprin beta gene in human cancer cells.
Fetuin-A and Cystatin C Are Endogenous Inhibitors of Human Meprin Metalloproteases.
Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro.
High concentration of neutral endopeptidase (enkephalinase E.C. 3.4.24.11) in a malignant tumor: rat hepatoma 3924A.
Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors.
Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2.
Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases.
MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma.
Meprin ? combined with CEA and CA19-9 improves prognostic prediction for surgically treated colorectal cancer patients.
Meprin A metalloproteinase and its role in acute kidney injury.
Meprin B: transcriptional and posttranscriptional regulation of the meprin beta metalloproteinase subunit in human and mouse cancer cells.
Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer.
Meprin-alpha metalloproteases enhance lipopolysaccharide-stimulated production of tumour necrosis factor-alpha and interleukin-1beta in peripheral blood mononuclear cells via activation of NF-kappaB.
Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3.
Metalloproteases meprin-? (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer.
Metalloproteinase meprin ? regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin.
Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma.
Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease.
Predictive value of MEP1A in cancer prognosis: A protocol for systematic review and meta-analysis.
Role of meprin metalloproteases in metastasis and tumor microenvironment.
Role of meprin metalloproteinases in cytokine processing and inflammation.
Shedding light on designing potential meprin ? inhibitors through ligand-based robust validated computational approaches: A proposal to chemists!
Structural basis for the sheddase function of human meprin ? metalloproteinase at the plasma membrane.
Structure of homo- and hetero-oligomeric meprin metalloproteases. Dimers, tetramers, and high molecular mass multimers.
The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation.
The cancer-associated meprin ? variant G32R provides an additional activation site and promotes cancer cell invasion.
The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion.
The metalloproteases meprin ? and meprin ?: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.
TNF-?-induced down-regulation of CDX2 suppresses MEP1A expression in colitis.
Urinary signatures of Renal Cell Carcinoma investigated by peptidomic approaches.
Neuroblastoma
Hydrolysis of atrial and brain natriuretic peptides by the human astrocytoma clone D384 and the neuroblastoma line SH-SY5Y.
Neurodegenerative Diseases
Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases.
Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease.
Potential role of calcifying nanoparticles in the etiology of multiple sclerosis.
Osteoarthritis
Neutral endopeptidase (3.4.24.11) in plasma and synovial fluid of patients with rheumatoid arthritis. A marker of disease activity or a regulator of pain and inflammation?
Osteosarcoma
Expression and regulation of the meprin beta gene in human cancer cells.
Pancreatic Neoplasms
Expression and regulation of the meprin beta gene in human cancer cells.
Parkinson Disease
Autophagy and innate immunity: Insights from invertebrate model organisms.
Periodontal Diseases
In vitro study of gingival fibroblasts from normal and inflamed tissue: age-related responsiveness.
Polycystic Kidney Diseases
Fine mapping of MEP1A, the gene encoding the alpha subunit of the metalloendopeptidase meprin, to human chromosome 6P21.
Polycystic Kidney, Autosomal Recessive
Fine mapping of MEP1A, the gene encoding the alpha subunit of the metalloendopeptidase meprin, to human chromosome 6P21.
Polycystic Ovary Syndrome
Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome.
Porcine Reproductive and Respiratory Syndrome
Autophagy and innate immunity: Insights from invertebrate model organisms.
Pre-Eclampsia
Increased immunohistochemical expression of neutral metalloendopeptidase (enkephalinase; EC 3.4.24.11) in villi of the human placenta with pre-eclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Characterisation of enkephalinase (EC 3.4.24.11) activity on various leukemic cells expressing the common acute lymphocytic leukemia antigen (CALLA).
Common acute lymphoblastic leukemia antigen expressed on leukemia and melanoma cell lines has neutral endopeptidase activity.
Comparative levels of CALLA/neutral endopeptidase on normal granulocytes, leukemic cells, and transfected COS-1 cells.
Detection of neutral endopeptidase-24.11/CD10 by flow cytometry and photomicroscopy using a new fluorescent inhibitor.
Exon 16 del: a novel form of human neutral endopeptidase (CALLA).
Increase of neutral endopeptidase-24.11 with cellular density and enzyme modulation with an inhibitor on human Reh6 cell line.
Increased expression of neprilysin (neutral endopeptidase 24.11) in rat and human hepatocellular carcinomas.
Increased serum neutral endopeptidase activity in acute renal allograft rejection.
Neutral endopeptidase modulates septic shock.
Neutral endopeptidase modulation of septic shock.
Thiorphan stimulates clonal growth of GM-CFU in short-term cultures of bone marrow from a healthy donor and from patients with non-Hodgkin lymphoma.
[Membrane metalloendopeptidase (CD10/CALLA): distribution, physiologic and pathophysiologic functions and its inhibitors]
Prostatic Neoplasms
A genetic screen in Drosophila for regulators of human prostate cancer progression.
Role of meprin metalloproteases in metastasis and tumor microenvironment.
Psoriasis
Syndecan-1 shedding by meprin ? impairs keratinocyte adhesion and differentiation in hyperkeratosis.
The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation.
Pulmonary Edema
Inhibition of Meprins Reduces Pulmonary Edema in LPS-Induced Acute Lung Damage.
Renal Insufficiency
First insight into structure-activity relationships of selective meprin ? inhibitors.
Shedding light on designing potential meprin ? inhibitors through ligand-based robust validated computational approaches: A proposal to chemists!
Reperfusion Injury
Meprin A, the major matrix degrading enzyme in renal tubules, produces a novel nidogen fragment in vitro and in vivo.
Meprin, a brush-border enzyme, plays an important role in hypoxic/ischemic acute renal tubular injury in rats.
Sepsis
ACTINONIN, A MEPRIN A INHIBITOR, PROTECTS THE RENAL MICROCIRCULATION DURING SEPSIS.
Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta.
Silicosis
Inhibition of miR-155-5p Exerts Anti-Fibrotic Effects in Silicotic Mice by Regulating Meprin ?.
Ureteral Obstruction
Expression of subunits of the metalloendopeptidase meprin in renal cortex in experimental hydronephrosis.
Urinary Tract Infections
Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge.
Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer.
Vesicular Stomatitis
Autophagy and innate immunity: Insights from invertebrate model organisms.