Disease on EC 3.4.24.18 - meprin A
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Acute Kidney Injury
Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats.
Acute Kidney Injury
ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A.
Acute Kidney Injury
Meprin ? Activity Modulates the beta Catalytic Subunit of Protein Kinase A (PKA C?) in Ischemia/Reperfusion-Induced Acute Kidney Injury.
Acute Kidney Injury
Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge.
Acute Lung Injury
Inhibition of Meprins Reduces Pulmonary Edema in LPS-Induced Acute Lung Damage.
Adenocarcinoma, Mucinous
Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries.
Alopecia
Syndecan-1 shedding by meprin ? impairs keratinocyte adhesion and differentiation in hyperkeratosis.
Alzheimer Disease
Expression, purification and initial characterization of human meprin ? from Pichia pastoris.
Alzheimer Disease
Shedding light on designing potential meprin ? inhibitors through ligand-based robust validated computational approaches: A proposal to chemists!
Alzheimer Disease
Tetraspanin 8 is an interactor of the metalloprotease meprin ? within tetraspanin-enriched microdomains.
Amyotrophic Lateral Sclerosis
Calcium negatively regulates meprin ? activity and attenuates substrate cleavage.
Arthritis
Elevated synovial tissue concentration of the common acute lymphoblastic leukaemia antigen (CALLA)-associated neutral endopeptidase (3.4.24.11) in human chronic arthritis.
Arthritis, Rheumatoid
Neutral endopeptidase (3.4.24.11) in plasma and synovial fluid of patients with rheumatoid arthritis. A marker of disease activity or a regulator of pain and inflammation?
Arthritis, Rheumatoid
Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B.
Astrocytoma
Hydrolysis of atrial and brain natriuretic peptides by the human astrocytoma clone D384 and the neuroblastoma line SH-SY5Y.
Atherosclerosis
A meprin inhibitor suppresses atherosclerotic plaque formation in ApoE(-/-) mice.
Atherosclerosis
Potential role of calcifying nanoparticles in the etiology of multiple sclerosis.
Atherosclerosis
Vascular neutral endopeptidase inhibition improves endothelial function and reduces intimal hyperplasia.
Bone Resorption
Inhibition of bone resorption in vitro by human enkephalinase (EC 3.4.24.11), a neutral metalloendopeptidase.
Breast Neoplasms
Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.
Bronchial Hyperreactivity
Correlation between neutral endopetidase (NEP) 3.4.24.11 in serum and the degree of the bronchial hyperreactivity.
Carcinoma
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin ? and promotes transendothelial cell migration.
Carcinoma
Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro.
Carcinoma
Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries.
Carcinoma
Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma.
Carcinoma
Structure of the mouse metalloprotease meprin beta gene (Mep1b): alternative splicing in cancer cells.
Carcinoma, Hepatocellular
High concentration of neutral endopeptidase (enkephalinase E.C. 3.4.24.11) in a malignant tumor: rat hepatoma 3924A.
Carcinoma, Hepatocellular
MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma.
Carcinoma, Lewis Lung
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin ? and promotes transendothelial cell migration.
Cardiomegaly
Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation.
Cardiovascular Diseases
B-Type Natriuretic Peptide 8-32 (BNP 8-32), Which is Produced From Mature BNP 1-32 by the Metalloprotease Meprin A, has Reduced Bioactivity.
Cardiovascular Diseases
Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2.
Colitis
Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease.
Colitis, Ulcerative
MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease.
Colitis, Ulcerative
TNF-?-induced down-regulation of CDX2 suppresses MEP1A expression in colitis.
Colonic Neoplasms
Meprin B: transcriptional and posttranscriptional regulation of the meprin beta metalloproteinase subunit in human and mouse cancer cells.
Colonic Neoplasms
Multistage vector delivery of sulindac and silymarin for prevention of colon cancer.
Colorectal Neoplasms
Activation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating system.
Colorectal Neoplasms
Erratum: Meprin ? combined with CEA and CA19-9 improves prognostic prediction for surgically treated colorectal cancer patients.
Colorectal Neoplasms
Meprin ? combined with CEA and CA19-9 improves prognostic prediction for surgically treated colorectal cancer patients.
Colorectal Neoplasms
Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma.
Colorectal Neoplasms
Role of meprin metalloproteases in metastasis and tumor microenvironment.
Cough
Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs.
Cystic Fibrosis
Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.
Dehydration
Combined effects of water stress and high temperature on photosynthesis, nitrogen metabolism and lipid peroxidation of a perennial grass Leymus chinensis.
Diabetes Mellitus, Type 1
LC-MS-based metabolomics analysis to identify meprin ?-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury.
Diabetes Mellitus, Type 1
Meprin ? metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy.
Diabetes Mellitus, Type 1
Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes.
Diabetic Nephropathies
Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities.
Diabetic Nephropathies
LC-MS-based metabolomics analysis to identify meprin ?-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury.
Diabetic Nephropathies
Meprin ? metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy.
Diabetic Nephropathies
Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians.
Diabetic Nephropathies
Meprin-alpha in chronic diabetic nephropathy: interaction with the renin-angiotensin axis.
Diabetic Nephropathies
Targeted disruption of the meprin beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles.
Diabetic Nephropathies
Undiagnosed Kidney Injury in Uninsured and Underinsured Diabetic African American Men and Putative Role of Meprin Metalloproteases in Diabetic Nephropathy.
Endometrial Neoplasms
The cancer-associated meprin ? variant G32R provides an additional activation site and promotes cancer cell invasion.
Endotoxemia
Reduced Expression of Extracellular Matrix Proteins in the Heart and Kidneys of Rats with Endotoxemia under the Effect of Actinonin.
Enteritis
Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A.
Essential Hypertension
Chronic inhibition of endopeptidase 24.11 in essential hypertension: evidence for enhanced atrial natriuretic peptide and angiotensin II.
Essential Hypertension
Inhibition of endopeptidase EC 3.4.24.11 by candoxatril lowered blood pressure and increased urinary but not plasma atrial natriuretic peptide in essential hypertension.
Exocrine Pancreatic Insufficiency
Non-pancreatic hydrolysis of N-benzoyl-l-tyrosyl-p-aminobenzoic acid (PABA-peptide) in the human small intestine.
Familial Primary Pulmonary Hypertension
Meprin ?, a novel mediator of vascular remodelling underlying pulmonary hypertension.
Gallstones
Evidence for oxidative stress in the gall bladder mucosa of gall stone patients.
Gastrointestinal Neoplasms
Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries.
Glioblastoma
Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.
Glomerulonephritis
Downregulated expression in high IgA (HIGA) mice and the renal protective role of meprinbeta.
Glomerulonephritis
Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis.
Glomerulonephritis, Membranous
Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis.
Heart Failure
Effects of alatriopril, a mixed inhibitor of atriopeptidase and angiotensin I-converting enzyme, on cardiac hypertrophy and hormonal responses in rats with myocardial infarction. Comparison with captopril.
Heart Failure
Inhibition of neutral endopeptidase 3.4.24.11 in conscious dogs with pacing induced heart failure.
Heart Failure
Mercaptoacyl dipeptides as orally active dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase.
Heart Failure
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.
Heart Failure
Potentiation of brain natriuretic peptides by SQ 28,603, an inhibitor of neutral endopeptidase 3.4.24.11, in monkeys and rats.
Heart Failure
Pulmonary and renal neutral endopeptidase EC 3.4.24.11 in rats with experimental heart failure.
Heart Failure
Systemic hemodynamics, renal function and hormonal levels during inhibition of neutral endopeptidase 3.4.24.11 and angiotensin-converting enzyme in conscious dogs with pacing-induced heart failure.
Heart Failure
The atriopeptidase inhibitor UK 69,578 increases atrial natriuretic factor and causes a natriuresis in normal humans.
Hydronephrosis
Expression of subunits of the metalloendopeptidase meprin in renal cortex in experimental hydronephrosis.
Hypertension
Meprin ?, a novel mediator of vascular remodelling underlying pulmonary hypertension.
Hypertension
Mercaptoacyl dipeptides as orally active dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase.
Hypertension
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.
Hypertension
Potentiation of brain natriuretic peptides by SQ 28,603, an inhibitor of neutral endopeptidase 3.4.24.11, in monkeys and rats.
Hypertension
The atriopeptidase inhibitor UK 69,578 increases atrial natriuretic factor and causes a natriuresis in normal humans.
Hypertension, Pulmonary
Meprin ?, a novel mediator of vascular remodelling underlying pulmonary hypertension.
Hypertension, Pulmonary
Neutral endopeptidase 24.11 inhibition reduces pulmonary vascular remodeling in rats exposed to chronic hypoxia.
Hypertrophy, Right Ventricular
Neutral endopeptidase 24.11 inhibition reduces pulmonary vascular remodeling in rats exposed to chronic hypoxia.
Infections
Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge.
Infections
Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer.
Inflammatory Bowel Diseases
An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A.
Inflammatory Bowel Diseases
Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease.
Inflammatory Bowel Diseases
Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells.
Inflammatory Bowel Diseases
Fetuin-A and Cystatin C Are Endogenous Inhibitors of Human Meprin Metalloproteases.
Inflammatory Bowel Diseases
First insight into structure-activity relationships of selective meprin ? inhibitors.
Inflammatory Bowel Diseases
Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities.
Inflammatory Bowel Diseases
MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease.
Inflammatory Bowel Diseases
Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis.
Inflammatory Bowel Diseases
Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease.
Inflammatory Bowel Diseases
Post-transcriptional regulation of meprin ? by the RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP).
Inflammatory Bowel Diseases
Shedding light on designing potential meprin ? inhibitors through ligand-based robust validated computational approaches: A proposal to chemists!
Inflammatory Bowel Diseases
Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin ? Inhibitors.
Insulin Resistance
Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome.
Leukemia
CD10 and CD44 genes of leukemic cells and malignant cell lines show no evidence of transformation-related alterations.
Liver Diseases
MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma.
Liver Neoplasms
MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma.
Lung Neoplasms
Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin ? but alter cell migration in vitro.
Lung Neoplasms
Effects of recombinant neutral endopeptidase (EC 3.4.24.11) on the growth of lung cancer cell lines in vitro and in vivo.
Lymphoma, Non-Hodgkin
Thiorphan stimulates clonal growth of GM-CFU in short-term cultures of bone marrow from a healthy donor and from patients with non-Hodgkin lymphoma.
meprin a deficiency
Certain mouse strains are deficient in a kidney brush-border metallo-endopeptidase activity.
meprin a deficiency
Deficiency of a kidney metalloproteinase activity in inbred mouse strains.
meprin a deficiency
Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells.
meprin a deficiency
Distinct contributions of meprins to skin regeneration after injury - Meprin ? a physiological processer of pro-collagen VII.
meprin a deficiency
Mep-1 gene controlling a kidney metalloendopeptidase is linked to the major histocompatibility complex in mice.
meprin a deficiency
Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation.
meprin a deficiency
Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes.
meprin a deficiency
Meprin-? (Mep1A) enhances TNF-? secretion by mast cells and aggravates abdominal aortic aneurysms.
Migraine Disorders
Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG.
Multiple Sclerosis
Potential role of calcifying nanoparticles in the etiology of multiple sclerosis.
Myoclonic Epilepsy, Juvenile
Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG.
Neoplasm Metastasis
Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries.
Neoplasm Metastasis
Meprin ? combined with CEA and CA19-9 improves prognostic prediction for surgically treated colorectal cancer patients.
Neoplasm Metastasis
Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma.
Neoplasm Metastasis
Role of meprin metalloproteases in metastasis and tumor microenvironment.
Neoplasm Metastasis
Shedding light on designing potential meprin ? inhibitors through ligand-based robust validated computational approaches: A proposal to chemists!
Neoplasms
Activation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating system.
Neoplasms
An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A.
Neoplasms
Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation.
Neoplasms
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin ? and promotes transendothelial cell migration.
Neoplasms
Fetuin-A and Cystatin C Are Endogenous Inhibitors of Human Meprin Metalloproteases.
Neoplasms
Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro.
Neoplasms
High concentration of neutral endopeptidase (enkephalinase E.C. 3.4.24.11) in a malignant tumor: rat hepatoma 3924A.
Neoplasms
Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors.
Neoplasms
Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2.
Neoplasms
Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases.
Neoplasms
MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma.
Neoplasms
Meprin ? combined with CEA and CA19-9 improves prognostic prediction for surgically treated colorectal cancer patients.
Neoplasms
Meprin B: transcriptional and posttranscriptional regulation of the meprin beta metalloproteinase subunit in human and mouse cancer cells.
Neoplasms
Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer.
Neoplasms
Meprin-alpha metalloproteases enhance lipopolysaccharide-stimulated production of tumour necrosis factor-alpha and interleukin-1beta in peripheral blood mononuclear cells via activation of NF-kappaB.
Neoplasms
Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3.
Neoplasms
Metalloproteases meprin-? (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer.
Neoplasms
Metalloproteinase meprin ? regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin.
Neoplasms
Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma.
Neoplasms
Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease.
Neoplasms
Predictive value of MEP1A in cancer prognosis: A protocol for systematic review and meta-analysis.
Neoplasms
Shedding light on designing potential meprin ? inhibitors through ligand-based robust validated computational approaches: A proposal to chemists!
Neoplasms
Structural basis for the sheddase function of human meprin ? metalloproteinase at the plasma membrane.
Neoplasms
Structure of homo- and hetero-oligomeric meprin metalloproteases. Dimers, tetramers, and high molecular mass multimers.
Neoplasms
The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation.
Neoplasms
The cancer-associated meprin ? variant G32R provides an additional activation site and promotes cancer cell invasion.
Neoplasms
The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion.
Neoplasms
The metalloproteases meprin ? and meprin ?: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.
Neoplasms
Urinary signatures of Renal Cell Carcinoma investigated by peptidomic approaches.
Neuroblastoma
Hydrolysis of atrial and brain natriuretic peptides by the human astrocytoma clone D384 and the neuroblastoma line SH-SY5Y.
Neurodegenerative Diseases
Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases.
Neurodegenerative Diseases
Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease.
Neurodegenerative Diseases
Potential role of calcifying nanoparticles in the etiology of multiple sclerosis.
Osteoarthritis
Neutral endopeptidase (3.4.24.11) in plasma and synovial fluid of patients with rheumatoid arthritis. A marker of disease activity or a regulator of pain and inflammation?
Pancreatic Neoplasms
Expression and regulation of the meprin beta gene in human cancer cells.
Parkinson Disease
Autophagy and innate immunity: Insights from invertebrate model organisms.
Periodontal Diseases
In vitro study of gingival fibroblasts from normal and inflamed tissue: age-related responsiveness.
Polycystic Kidney Diseases
Fine mapping of MEP1A, the gene encoding the alpha subunit of the metalloendopeptidase meprin, to human chromosome 6P21.
Polycystic Kidney, Autosomal Recessive
Fine mapping of MEP1A, the gene encoding the alpha subunit of the metalloendopeptidase meprin, to human chromosome 6P21.
Polycystic Ovary Syndrome
Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome.
Porcine Reproductive and Respiratory Syndrome
Autophagy and innate immunity: Insights from invertebrate model organisms.
Pre-Eclampsia
Increased immunohistochemical expression of neutral metalloendopeptidase (enkephalinase; EC 3.4.24.11) in villi of the human placenta with pre-eclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Characterisation of enkephalinase (EC 3.4.24.11) activity on various leukemic cells expressing the common acute lymphocytic leukemia antigen (CALLA).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Common acute lymphoblastic leukemia antigen expressed on leukemia and melanoma cell lines has neutral endopeptidase activity.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Comparative levels of CALLA/neutral endopeptidase on normal granulocytes, leukemic cells, and transfected COS-1 cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Detection of neutral endopeptidase-24.11/CD10 by flow cytometry and photomicroscopy using a new fluorescent inhibitor.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Exon 16 del: a novel form of human neutral endopeptidase (CALLA).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Increase of neutral endopeptidase-24.11 with cellular density and enzyme modulation with an inhibitor on human Reh6 cell line.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Increased expression of neprilysin (neutral endopeptidase 24.11) in rat and human hepatocellular carcinomas.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Increased serum neutral endopeptidase activity in acute renal allograft rejection.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Neutral endopeptidase modulates septic shock.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Neutral endopeptidase modulation of septic shock.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiorphan stimulates clonal growth of GM-CFU in short-term cultures of bone marrow from a healthy donor and from patients with non-Hodgkin lymphoma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Membrane metalloendopeptidase (CD10/CALLA): distribution, physiologic and pathophysiologic functions and its inhibitors]
Prostatic Neoplasms
A genetic screen in Drosophila for regulators of human prostate cancer progression.
Prostatic Neoplasms
Role of meprin metalloproteases in metastasis and tumor microenvironment.
Psoriasis
Syndecan-1 shedding by meprin ? impairs keratinocyte adhesion and differentiation in hyperkeratosis.
Psoriasis
The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation.
Pulmonary Edema
Inhibition of Meprins Reduces Pulmonary Edema in LPS-Induced Acute Lung Damage.
Renal Insufficiency
First insight into structure-activity relationships of selective meprin ? inhibitors.
Renal Insufficiency
Shedding light on designing potential meprin ? inhibitors through ligand-based robust validated computational approaches: A proposal to chemists!
Reperfusion Injury
Meprin A, the major matrix degrading enzyme in renal tubules, produces a novel nidogen fragment in vitro and in vivo.
Reperfusion Injury
Meprin, a brush-border enzyme, plays an important role in hypoxic/ischemic acute renal tubular injury in rats.
Sepsis
Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta.
Silicosis
Inhibition of miR-155-5p Exerts Anti-Fibrotic Effects in Silicotic Mice by Regulating Meprin ?.
Ureteral Obstruction
Expression of subunits of the metalloendopeptidase meprin in renal cortex in experimental hydronephrosis.
Urinary Tract Infections
Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge.
Urinary Tract Infections
Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer.
Vesicular Stomatitis
Autophagy and innate immunity: Insights from invertebrate model organisms.
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