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Disease on EC 3.4.24.17 - stromelysin 1

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DISEASE
TITLE OF PUBLICATION
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Abortion, Spontaneous
Differential Expression of EGFR-1, MMP-3, and MMP-9 in Spontaneous Abortions, Induced Abortions, and Tubal Pregnancies.
Acantholysis
Idiopathic gingival hypertrophy--a morphological study and a review of literature.
Acute Coronary Syndrome
Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development.
Genotype-phenotype association of matrix metalloproteinase-3 polymorphism and its synergistic effect with smoking on the occurrence of acute coronary syndrome.
Lack of an association between connexin-37, stromelysin-1, plasminogen activator-inhibitor type 1 and lymphotoxin-alpha genes and acute coronary syndrome in Czech Caucasians.
Serum Levels of Matrix Metalloproteinase (MMP) 9, a Risk Factor for Acute Coronary Syndrome, Are Reduced Independently of Serum MMP-3 by Anti-TNF-? Antibody (Infliximab) Therapy in Patients With Rheumatoid Arthritis.
Usefulness of Plasma Matrix Metalloproteinase-3 Levels to Predict Myocardial Infarction in Men With and Without Acute Coronary Syndrome.
Acute Kidney Injury
Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells.
Increased expression of kidney injury molecule-1 and matrix metalloproteinase-3 in severe Plasmodium falciparum malaria with acute kidney injury.
Acute Lung Injury
Role of stromelysin 1 and gelatinase B in experimental acute lung injury.
The effect of matrix metalloproteinase-3 deficiency on pulmonary surfactant in a mouse model of acute lung injury.
The importance of matrix metalloproteinase-3 in respiratory disorders.
Adenocarcinoma
Androgen-repressed phenotype in human prostate cancer.
Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis.
Epimorphin overexpression in the mouse mammary gland promotes alveolar hyperplasia and mammary adenocarcinoma.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression.
Expression of metalloproteinase genes in human prostate cancer.
Expression of metalloproteinases and their inhibitors in adenocarcinoma of the uterine cervix.
Expression of the transin, c-fos, and c-jun genes in rat transplantable osteosarcomas and malignant fibrous histiocytomas.
Interleukin 1beta induces gastric epithelial cell matrix metalloproteinase secretion and activation during Helicobacter pylori infection.
The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinoma.
TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma.
[Changes in markers of proliferation, neoangiogenesis and plasminogen activation system in rectal cancer tissue].
[Correlation of matrix metalloproteinase-3 polymorphism to genetic susceptibility and lymph node metastasis of non-small cell lung cancer]
Adenocarcinoma of Lung
Immunocytochemical detection of matrix metalloproteinase expression in prostate cancer.
Immunocytochemical detection of the expression of members of the matrix metalloproteinase family in adenocarcinomas of the pancreas.
Increased expression of matrix metalloproteinases mediates thromboxane A2-induced invasion in lung cancer cells.
Invasion and metastasis: the expression and significance of matrix metalloproteinases in carcinomas of the lung.
MiR-22-3p Expression is down-regulated in lung adenocarcinoma.
Adenoma
Matrix metalloproteinases, their tissue inhibitors and colorectal cancer staging.
Prognostic and predictive potential molecular biomarkers in colon cancer.
TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma.
Adenomyosis
Effect of matrix metalloproteinase promoter polymorphisms on endometriosis and adenomyosis risk: evidence from a meta-analysis.
[Expression of matrix metalloproteinase and tissue inhibitor of metalloproteinase in adenomyosis]
[Single nucleotide polymorphism in the matrix metalloproteinases promoter is associated with susceptibility to endometriosis and adenomyosis]
Aggressive Periodontitis
Pathogen profile and MMP-3 levels in areas with varied attachment loss in generalized aggressive and chronic periodontitis.
Airway Obstruction
Induced sputum metalloproteinases and their inhibitors in relation to exhaled nitrogen oxide and sputum nitric oxides and other inflammatory cytokines in patients with chronic obstructive pulmonary disease.
Albuminuria
Association Between Matrix Metalloproteinase-3 Activity and Glomerular Filtration Rate and Albuminuria Status in Patients With Type 2 Diabetes Mellitus.
Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: the EURODIAB Prospective Complications Study.
Alveolar Bone Loss
Danzhi Jiangtang capsule alleviate hyperglycemia and periodontitis via Wnt/?-catenin signaling in diabetic rat.
Alzheimer Disease
A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: Proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer's pathology.
Analysis of Matrix Metallo-Proteases and the Plasminogen System in Mild Cognitive Impairment and Alzheimer's Disease Cerebrospinal Fluid.
Concentrations of Matrix Metalloproteinases and their Tissue Inhibitors in the Cerebrospinal Fluid of Patients with Alzheimer's Disease.
Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease.
Interaction between matrix metalloproteinase 3 and the epsilon4 allele of apolipoprotein E increases the risk of Alzheimer's disease in Finns.
Matrix metalloproteinase 3 haplotypes and dementia and Alzheimer's disease. The Rotterdam Study.
Matrix metalloproteinase-3 in the central nervous system: a look on the bright side.
Plasma gelsolin and matrix metalloproteinase 3 as potential biomarkers for Alzheimer disease.
Role of Matrix Metalloproteinase-3 in Neurodegeneration.
Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's disease brain.
Serum levels of matrix metalloproteinases: implications in clinical neurology.
The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain.
Amyloidosis
A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: Proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer's pathology.
Increased levels of serum matrix metalloproteinase-3 in haemodialysis patients with dialysis-related amyloidosis.
Serum matrix metalloproteinase-3 in hemodialysis patients with dialysis-related amyloidosis.
Anemia
Scoring Model to Predict a Low Disease Activity in Elderly Rheumatoid Arthritis Patients Initially Treated with Biological Disease-modifying Antirheumatic Drugs.
Aneurysm
An increased frequency of the 5A allele in the promoter region of the MMP3 gene is associated with abdominal aortic aneurysms.
Association of the matrix metalloproteinase-3 (-439C/G) promoter polymorphism with Kawasaki disease in Korean children.
Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury.
Extracellular proteolysis in the development and progression of atherosclerosis.
Genes predisposing to rapid aneurysm growth.
Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis.
Homocysteine and metalloprotease-3 and -9 in patients with ascending Aorta Aneurysms.
Inflammatory Smooth Muscle Cells Induce Endothelial Cell Alterations to Influence Cerebral Aneurysm Progression via Regulation of Integrin and VEGF Expression.
Matrix metalloproteinase haplotypes associated with coronary artery aneurysm formation in patients with Kawasaki disease.
Persistence of atherosclerotic plaque but reduced aneurysm formation in mice with stromelysin-1 (MMP-3) gene inactivation.
Plasma matrix metalloproteinase levels do not predict tissue levels in abdominal aortic aneurysms suitable for elective repair.
Stromelysin-1 (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase-3 are overexpressed in the wall of abdominal aortic aneurysms.
Structural studies of the MMP-3 interaction with triple-helical collagen introduce new roles for the enzyme in tissue remodelling.
Upregulated sulfatase and downregulated MMP-3 in thoracic aortic aneurysm.
Aneurysm, Dissecting
Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia.
Angina, Stable
The roles of stromelysin-1 and the gelatinase B gene polymorphism in stable angina.
Angina, Unstable
Effect of matrix metalloproteinase and their inhibitors on atrial myocardial structural remodeling.
Anthrax
A new role for old ligands: discerning chelators for zinc metalloproteinases.
Latent cytokines: development of novel cleavage sites and kinetic analysis of their differential sensitivity to MMP-1 and MMP-3.
Statistical analysis, optimization, and prioritization of virtual screening parameters for zinc enzymes including the anthrax toxin lethal factor.
Aortic Aneurysm
Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease.
Aortic Aneurysm, Abdominal
An increased frequency of the 5A allele in the promoter region of the MMP3 gene is associated with abdominal aortic aneurysms.
Cellular localization of matrix metalloproteinases in the abdominal aortic aneurysm wall.
Genes predisposing to rapid aneurysm growth.
Genotype-phenotype relationships in an investigation of the role of proteases in abdominal aortic aneurysm expansion.
HMG-CoA reductase inhibitors (statins) decrease MMP-3 and MMP-9 concentrations in abdominal aortic aneurysms.
Immune cells and molecular mediators in the pathogenesis of the abdominal aortic aneurysm.
Stromelysin-1 (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase-3 are overexpressed in the wall of abdominal aortic aneurysms.
Upregulated sulfatase and downregulated MMP-3 in thoracic aortic aneurysm.
Aortic Aneurysm, Thoracic
Upregulated sulfatase and downregulated MMP-3 in thoracic aortic aneurysm.
Aortic Valve Stenosis
Impact of several proinflammatory and cell degradation factors in patients with aortic valve stenosis.
Arrhythmias, Cardiac
MMP-1 and MMP-3 polymorphism and arrhythmia recurrence after electrical cardioversion in patients with persistent atrial fibrillation.
Arteriovenous Malformations
The rs522616 polymorphism in the matrix metalloproteinase-3 (MMP-3) gene is associated with sporadic brain arteriovenous malformation in a Chinese population.
Arthralgia
Proinflammatory Cytokines and Chemokines as Biomarkers of Persistent Arthralgia and Severe Disease After Chikungunya Virus Infection: A 5-Year Follow-Up Study in Southern Thailand.
Serum matrix metalloproteinase-3 in systemic sclerosis.
The gene expression profile of matrix metalloproteinases and their inhibitors in children with Henoch-Schönlein purpura.
Usefulness of anti-cyclic citrullinated peptide antibody and rheumatoid factor to detect rheumatoid arthritis in patients with systemic sclerosis.
[Effect of acupoint heat-sensitive moxibustion intervention on serum osteopontin and matrix metalloproteinase-3 in patients with acute knee pain].
[Effect of Gancao Fuzi Decoction on osteoarthritis and proteomics of articular cartilage in rats].
Arthritis
A case of idiopathic hypertrophic cranial pachymeningitis presenting high values of matrix metalloproteinase.
A correlation between knee cartilage degradation observed by arthroscopy and synovial proteinases activities.
Activated gelatinase-B (MMP-9) and urokinase-type plasminogen activator in synovial fluids of patients with arthritis. Correlation with clinical and experimental variables of inflammation.
Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destruction.
Adiponectin increases MMP-3 expression in human chondrocytes through adipor1 signaling pathway.
An orally bioavailable synthetic analogue of an active DHEA metabolite reduces established disease in rodent models of rheumatoid arthritis.
Anti-arthritic activity of Fu-Fang-Lu-Jiao-Shuang on collagen-induced arthritis in Balb/c mice and its underlying mechanisms.
Arthritis associated with Kawasaki disease: MRI findings and serum matrix metalloproteinase-3 profiles.
Biomarkers of joint tissue metabolism in canine osteoarthritic and arthritic joint disorders.
CCAAT/enhancer binding protein ? regulates expression of matrix metalloproteinase-3 in arthritis.
CCR5 silencing reduces inflammatory response, inhibits viability, and promotes apoptosis of synovial cells in rat models of rheumatoid arthritis through the MAPK signaling pathway.
Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms.
Chikungunya Fever in Japan Imported from the Caribbean Islands.
Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers.
Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity.
Clinical significance of matrix metalloproteinase-3 in systemic lupus erythematosus patients: a potential biomarker for disease activity and damage.
Clinical, radiological, and biochemical characteristics in patients with diseases mimicking polymyalgia rheumatica.
Concomitant Treatment with Etanercept and Tacrolimus Synergistically Attenuates Arthritis Progression via Inhibition of Matrix Metalloproteinase-3 Production and Osteoclastogenesis in Human TNF-? Transgenic Mice.
Connective tissue metabolism in patients with unclassified polyarthritis and early rheumatoid arthritis. Relationship to disease activity, bone mineral density, and radiographic outcome.
Coordinate regulation of matrix metalloproteases and tissue inhibitor of metalloproteinase expression in human synovial fibroblasts.
Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis.
Differential in vivo expression of collagenase messenger RNA in synovium and cartilage. Quantitative comparison with stromelysin messenger RNA levels in human rheumatoid arthritis and osteoarthritis patients and in two animal models of acute inflammatory arthritis.
Drug-induced inhibition of proteoglycanase activity in the Hulth-Telhag model.
Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis.
Effect of Mycoplasma bovis on expression of inflammatory cytokines and matrix metalloproteinases mRNA in bovine synovial cells.
Elevated plasma stromelysin levels in arthritis.
Highly increased levels of active stromelysin in rheumatoid synovial fluid determined by a selective fluorogenic assay.
Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model.
Immunofluorescence quantitation of stromelysin in human synovial fibroblasts by confocal laser scanning microscopy.
Increased serum proMMP-3 in inflammatory arthritides: a potential indicator of synovial inflammatory monokine activity.
Influence of Matrix metalloproteinase 1 and 3 genetic variations on susceptibility and severity of juvenile idiopathic arthritis.
Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes.
Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides.
Inhibitory Effect of a Novel Antirheumatic Drug T-614 on the IL-6-Induced RANKL/OPG, IL-17, and MMP-3 Expression in Synovial Fibroblasts from Rheumatoid Arthritis Patients.
Inhibitory Effects of IL-6-Mediated Matrix Metalloproteinase-3 and -13 by Achyranthes japonica Nakai Root in Osteoarthritis and Rheumatoid Arthritis Mice Models.
Isolation and characterization of human monoclonal antibodies specific to MMP-1A, MMP-2 and MMP-3.
Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study.
Levels of rheumatoid factor isotypes, metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in synovial fluid from various arthritides.
Levels of serum matrix metalloproteinase-3 correlate with disease activity in the enthesitis-related arthritis category of juvenile idiopathic arthritis.
Link peptide cartilage growth factor is degraded by membrane proteinases.
Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-alpha.
Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens.
Matrix metalloproteinases: role in arthritis.
Mesenchymal stromal cells versus betamethasone can dampen disease activity in the collagen arthritis mouse model.
Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis.
Mice Deficient in CIZ/NMP4 Develop an Attenuated Form of K/BxN-Serum Induced Arthritis.
Modification of osteoarthritis by pulsed electromagnetic field--a morphological study.
Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in health.
Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint.
Overlapping Features in Kawasaki Disease-Related Arthritis and Systemic-Onset Juvenile Idiopathic Arthritis: A Nationwide Study in Japan.
Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice.
Pharmacological efficacy of anti-IL-1? scFv, Fab and full-length antibodies in treatment of rheumatoid arthritis.
Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice.
Predicting duration of beneficial effect of joint injection among children with chronic arthritis by measuring biomarkers concentration in synovial fluid at the time of injection.
Prediction of Antiarthritic Drug Efficacies by Monitoring Active Matrix Metalloproteinase-3 (MMP-3) Levels in Collagen-Induced Arthritic Mice Using the MMP-3 Probe.
Progressive polyarthritis induced in BALB/c mice by aggrecan from normal and osteoarthritic human cartilage.
Quantification of mRNA levels in joint capsule and articular cartilage of the murine knee joint by RT-PCR: kinetics of stromelysin and IL-1 mRNA levels during arthritis.
Rabbit models of arthritis: immunolocalization of matrix metalloproteinases and tissue inhibitor of metalloproteinase in synovium and cartilage.
Selective inhibition of PBEF/Visfatin/NAMPT suppresses leukocyte infiltration and cartilage degradation.
Serum and synovial fluid concentrations of matrix metalloproteinases 3 and its tissue inhibitor 1 in juvenile idiopathic arthritides.
Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study.
Serum microRNAs as Potential Biomarkers of Juvenile Idiopathic Arthritis.
Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages.
Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor.
Solution structures of stromelysin complexed to thiadiazole inhibitors.
Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme.
Structural studies of the MMP-3 interaction with triple-helical collagen introduce new roles for the enzyme in tissue remodelling.
Synergistic effects of interleukin-1? and interleukin-17A antibodies on collagen-induced arthritis mouse model.
Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not.
Synovial fluid RANKL and matrix metalloproteinase levels in enthesitis related arthritis subtype of juvenile idiopathic arthritis.
Synovial membrane expression of matrix metalloproteinases and tissue inhibitor 1 in juvenile idiopathic arthritides.
The 'RASor's' edge: Ras proteins and matrix destruction in arthritis.
The bispecific antibody aimed at the vicious circle of IL-1? and IL-17A, is beneficial for the collagen-induced rheumatoid arthritis of mice through NF-?B signaling pathway.
The diagnostic utility of matrix metalloproteinase-3 and high-sensitivity C-reactive protein for predicting rheumatoid arthritis in anti-cyclic citrullinated peptide antibody-negative patients with recent-onset undifferentiated arthritis.
The role of stromelysin in the cartilage destruction that accompanies inflammatory arthritis.
Tissue inhibitor of metalloproteinases-1 and matrix metalloproteinase-3 in Japanese healthy children and in Kawasaki disease and their clinical usefulness in juvenile rheumatoid arthritis.
Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats.
Triptolide decreases rheumatoid arthritis fibroblast-like synoviocyte proliferation, invasion, inflammation and presents a therapeutic effect in collagen-induced arthritis rats via inactivating lncRNA RP11-83J16.1 mediated URI1 and ?-catenin signaling.
Usefulness of anti-cyclic citrullinated peptide antibody and rheumatoid factor to detect rheumatoid arthritis in patients with systemic sclerosis.
Vanadate, an inhibitor of stromelysin and collagenase expression, suppresses collagen induced arthritis.
Venlafaxine alleviates complete Freund's adjuvant-induced arthritis in rats: Modulation of STAT-3/IL-17/RANKL axis.
[Electroacupuncture at "Zusanli"(ST36) and "Xuanzhong"(GB39) improves inflammatory reactions and reduces levels of serum MMP-3 and MMP-9 in adjuvant arthritis rats].
[Expression of matrix metalloproteinase-3 in patients with reheumatoid arthritis and its correlation with chronic periodontitis and rheumatoid arthritis].
[Matrix metalloproteinase-3 in patients with systemic lupus erythematosus and its significance in differentiating disease activity from pulmonary infections].
[Serum metalloproteinase-3 levels in assessing efficacy of Etanercept in patients with ankylosing spondylitis].
[Stromelysin-1 (MMP-3) level in the sera from patients with rheumatoid arthritis and other connective tissue diseases--clinical significances in early onset rheumatoid arthritis]
[Usefulness of serum matrix metalloproteinase-3(MMP-3) level in the diagnosis of rheumatoid arthritis]
Arthritis, Experimental
Aliskiren, tadalafil, and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freund's adjuvant arthritis model: Downregulation of IL-6/JAK2/STAT3 signaling pathway.
Cyr61 participates in the pathogenesis of rheumatoid arthritis via promoting MMP-3 expression by fibroblast-like synoviocytes.
Detection of active matrix metalloproteinase-3 in serum and fibroblast-like synoviocytes of collagen-induced arthritis mice.
Macrophage-Derived Delta-like Protein 1 Enhances Interleukin-6 and Matrix Metalloproteinase 3 Production by Fibroblast-like Synoviocytes in Mice With Collagen-Induced Arthritis.
Matrix metalloproteinases as targets for the immune system during experimental arthritis.
Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway.
Prediction of Antiarthritic Drug Efficacies by Monitoring Active Matrix Metalloproteinase-3 (MMP-3) Levels in Collagen-Induced Arthritic Mice Using the MMP-3 Probe.
Red ginseng saponin extract attenuates murine collagen-induced arthritis by reducing pro-inflammatory responses and matrix metalloproteinase-3 expression.
Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction.
The role of stromelysin in the cartilage destruction that accompanies inflammatory arthritis.
Therapeutic effects of the total lignans from Vitex negundo seeds on collagen-induced arthritis in rats.
Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats.
[Effect of electroacupuncture on articular morphological changes and serum inflammatory factors and synovial MMPs in collagen-induced arthritis rats].
[Electroacupuncture at "Zusanli"(ST36) and "Xuanzhong"(GB39) improves inflammatory reactions and reduces levels of serum MMP-3 and MMP-9 in adjuvant arthritis rats].
Arthritis, Gouty
Detection of stromelysin in synovial fluid and serum from patients with rheumatoid arthritis and osteoarthritis.
Levels of rheumatoid factor isotypes, metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in synovial fluid from various arthritides.
Matrix Metalloproteinase-3 induces proteoglycan degradation in gouty arthritis model.
[Stromelysin-1 (MMP-3) level in the sera from patients with rheumatoid arthritis and other connective tissue diseases--clinical significances in early onset rheumatoid arthritis]
Arthritis, Infectious
Dexamethasone attenuation of cytokine-mediated articular cartilage degradation in experimental lapine Haemophilus arthritis.
Longitudinal and cross-sectional variability in markers of joint metabolism in patients with knee pain and articular cartilage abnormalities.
Purified staphylococcal culture medium stimulates neutral metalloprotease secretion from human articular cartilage.
Arthritis, Juvenile
Influence of Matrix metalloproteinase 1 and 3 genetic variations on susceptibility and severity of juvenile idiopathic arthritis.
Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study.
Levels of serum matrix metalloproteinase-3 correlate with disease activity in the enthesitis-related arthritis category of juvenile idiopathic arthritis.
Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in health.
Tissue inhibitor of metalloproteinases-1 and matrix metalloproteinase-3 in Japanese healthy children and in Kawasaki disease and their clinical usefulness in juvenile rheumatoid arthritis.
Arthritis, Psoriatic
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
Increased serum TWEAK levels in Psoriatic arthritis: relationship with disease activity and matrix metalloproteinase-3 serum levels.
Lipoma arborescens co-existing with psoriatic arthritis releases tumour necrosis factor alpha and matrix metalloproteinase 3.
Possible molecular mechanisms to account for the involvement of tryptase in the pathogenesis of psoriasis.
Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study.
Ultrasound assessment, unlike clinical assessment, reflects enthesitis in patients with psoriatic arthritis.
Arthritis, Reactive
Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not.
Arthritis, Rheumatoid
A high throughput fluorogenic substrate for stromelysin (MMP-3).
A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 3 (stromelysin-1) using monoclonal antibodies.
Activation of progelatinase B in synovial fluids of patients with rheumatoid arthritis, with reference to stromelysin-1 and tissue inhibitor of matrix metalloproteinase-1.
Alteration of matrix metalloproteinase-3 O-glycan structure as a biomarker for disease activity of rheumatoid arthritis.
Amelioration of rheumatoid arthritis in a breast cancer patient treated with palbociclib: a case report.
Anti-inflammatory and anti-arthritic effects of the ethanolic extract of Aralia continentalis Kitag. in IL-1?-stimulated human fibroblast-like synoviocytes and rodent models of polyarthritis and nociception.
Argatroban more effectively inhibits the thrombin activity in synovial fluid than naturally occurring thrombin inhibitors.
Association of baseline levels of urinary glucosyl-galactosyl-pyridinoline and type II collagen C-telopeptide with progression of joint destruction in patients with early rheumatoid arthritis.
Association of heterogeneity of the thyroid gland with matrix metalloproteinase-3 in rheumatoid arthritis patients with Hashimoto's thyroiditis.
Association of matrix metalloproteinase 3 promoter genotype with disease outcome in rheumatoid arthritis.
Association of the 5A/6A Promoter Polymorphism of the MMP-3 Gene with the Radiographic Progression of Rheumatoid Arthritis.
Association Study of Matrix Metalloproteinases Gene Polymorphisms with Susceptibility to Rheumatoid Arthritis: A Meta-Analysis.
Associations of Changes in Serum Inflammatory Factors, MMP-3, 25(OH)D and Intestinal Flora with Osteoporosis and Disease Activity in Rheumatoid Arthritis Patients.
Autoantibodies to cyclic citrullinated peptide 2 (CCP2) are superior to other potential diagnostic biomarkers for predicting rheumatoid arthritis in early undifferentiated arthritis.
Autocrine induction of gliostatin/platelet-derived endothelial cell growth factor (GLS/PD-ECGF) and GLS-induced expression of matrix metalloproteinases in rheumatoid arthritis synoviocytes.
Baseline serum level of matrix metalloproteinase-3 as a biomarker of progressive joint damage in rheumatoid arthritis patients.
Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up.
Biomarkers for diagnosing and monitoring autoimmune diseases.
Cartilage damaging activities of fibronectin fragments derived from cartilage and synovial fluid.
Caution is needed when interpreting changes of matrix metalloproteinase-3 in patients with rheumatoid arthritis.
Cinnamomulactone, a new butyrolactone from the twigs of Cinnamomum cassia and its inhibitory activity of matrix metalloproteinases.
Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers.
Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts.
Comment on "Comparison of MMP-3 levels in rheumatoid arthritis after treatment with tocilizumab or infliximab for 12 weeks" by Yokoe et al.
Comment on 'Baseline serum level of matrix metalloproteinase-3 as a biomarker of progressive joint damage in rheumatoid arthritis patients'.
Comparative studies of collagenase and stromelysin-1 expression by rheumatoid synoviocytes in vitro.
Comparison of MMP-3 levels in rheumatoid arthritis after treatment with tocilizumab or infliximab for 12 weeks.
Continuously elevated serum matrix metalloproteinase-3 for 3 ~ 6 months predict one-year radiographic progression in rheumatoid arthritis: a prospective cohort study.
Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts.
Correction: Serum matrix metalloproteinase 3 levels are associated with an effect of iguratimod as add-on therapy to biological DMARDs in patients with rheumatoid arthritis.
Correlation between the appearance of gelatinases in the synovial fluid of patients with rheumatoid arthritis and polymorphonuclear elastase, stromelysin-1, and the tissue inhibitor of metalloproteinase-1.
Cyr61 participates in the pathogenesis of rheumatoid arthritis via promoting MMP-3 expression by fibroblast-like synoviocytes.
Decrease of CD68 and MMP-3 expression in synovium by treatment of adalimumab for rheumatoid arthritis.
Decrement of serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis (RA) patients achieving remission after 6 months of etanercept treatment: comparison with CRP, IgM-RF, MMP-3 and anti-CCP Ab.
Detection of high levels of 2 specific isoforms of 14-3-3 proteins in synovial fluid from patients with joint inflammation.
Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury.
Detection of stromelysin in synovial fluid and serum from patients with rheumatoid arthritis and osteoarthritis.
Determination of stromelysin-1, 72 and 92 kDa type IV collagenase, tissue inhibitor of metalloproteinase-1 (TIMP-1), and TIMP-2 in synovial fluid and serum from patients with rheumatoid arthritis.
Dexmedetomidine inhibits the invasion, migration, and inflammation of rheumatoid arthritis fibroblast-like synoviocytes by reducing the expression of NLRC5.
Differential in vivo expression of collagenase messenger RNA in synovium and cartilage. Quantitative comparison with stromelysin messenger RNA levels in human rheumatoid arthritis and osteoarthritis patients and in two animal models of acute inflammatory arthritis.
Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression.
DMARD aurothiomalate inhibits COX-2, MMP-3 and IL-6 expression in chondrocytes by increasing MKP-1 expression and decreasing p38 phosphorylation.
Does gamma-aminobutyric acid (GABA) influence the development of chronic inflammation in rheumatoid arthritis?
Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis.
Effect of downregulation of serum MMP-3 levels by traditional Chinese medicine ingredients combined with methotrexate on the progression of bone injury in patients with rheumatoid arthritis: A protocol for a systematic review and meta-analysis.
Effect of Moxibustion on the Serum Levels of MMP-1, MMP-3, and VEGF in Patients with Rheumatoid Arthritis.
Effect of Tenidap on Metalloproteinase Gene Expression in Rheumatoid Arthritis: A Synovial Biopsy Study.
Effects of Alpha-Lipoic Acid Supplementation on Inflammatory Biomarkers and Matrix Metalloproteinase-3 in Rheumatoid Arthritis Patients.
Effects of celecoxib on human chondrocytes--enhanced production of chemokines.
Effects of Vitamin K on Matrix Metalloproteinase-3 and Rheumatoid Factor in Women with Rheumatoid Arthritis: A Randomized, Double-Blind, Placebo-Controlled Trial.
Elevated levels of soluble Fas (APO-1, CD95), soluble Fas ligand, and matrix metalloproteinase-3 in sera from patients with active untreated adult onset Still's disease.
Elevated matrix metalloproteinase-3 level may affect hearing function in patients with rheumatoid arthritis.
Elevated oxidative stress monitored via the albumin-thiol redox state is correlated with matrix metalloproteinase-3 elevation in patients with rheumatoid arthritis.
Elevated plasma stromelysin levels in arthritis.
Elevation of serum matrix metalloproteinase-3 as a predictive marker for the long-term disability of rheumatoid arthritis patients in a prospective observational cohort IORRA.
Erosive pustular dermatosis of the scalp arising concomitantly with elevation of serum matrix metalloproteinase-3 in a patient with rheumatoid arthritis.
Erratum to: Continuously elevated serum matrix metalloproteinase-3 for 3 ~ 6 months predict one-year radiographic progression in rheumatoid arthritis: a prospective cohort study.
Erratum to: Reply to: Comment on ''Comparison of MMP-3 levels in rheumatoid arthritis after treatment with tocilizumab or infliximab for 12 weeks'' by Yokoe et al.
Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis.
Expression of interleukin-1 beta, tumor necrosis factor alpha, interleukins-6, -10 and -4, and metalloproteases by freshly isolated mononuclear cells from early never-treated and non-acute treated rheumatoid arthritis patients.
Expression of metalloproteinases and metalloproteinase inhibitor in human arthritic synovium.
Expression of T follicular helper lymphocytes with different subsets and analysis of serum IL-6, IL-17, TGF-? and MMP-3 contents in patients with rheumatoid arthritis.
Fluorogenic Probe for Detecting Active Matrix Metalloproteinase-3 (MMP-3) in Plasma and Peripheral Blood Neutrophils to Indicate the Severity of Rheumatoid Arthritis.
Heat shock of rabbit synovial fibroblasts increases expression of mRNAs for two metalloproteinases, collagenase and stromelysin.
High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis.
High rate of improvement in serum matrix metalloproteinase-3 levels at 4 weeks predicts remission at 52 weeks in RA patients treated with adalimumab.
High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion.
Higher levels of matrix metalloproteinase-3 in patients with RA reflect disease activity and structural damage.
Highly increased levels of active stromelysin in rheumatoid synovial fluid determined by a selective fluorogenic assay.
Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3).
Identification of new autolytic sites of recombinant truncated mature human fibroblast stromelysin by mass spectrometry.
IgG anti-hinge antibodies against IgG4 F(ab')2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes.
IL-1 regulation of transin/stromelysin transcription in rheumatoid synovial fibroblasts appears to involve two antagonistic transduction pathways, an inhibitory, prostaglandin-dependent pathway mediated by cAMP, and a stimulatory, protein kinase C-dependent pathway.
IL-33 regulates TNF-? dependent effects in synovial fibroblasts.
Immunofluorescence quantitation of stromelysin in human synovial fibroblasts by confocal laser scanning microscopy.
Immunolocalization of matrix metalloproteinase 3 (stromelysin) in rheumatoid synovioblasts (B cells): correlation with rheumatoid arthritis.
Impact of disease activity on impaired glucose metabolism in patients with rheumatoid arthritis.
Improvement in matrix metalloproteinase-3 independently predicts low disease activity at 52 weeks in bio-switch rheumatoid arthritis patients treated with abatacept.
In situ hybridization of stromelysin mRNA in the synovial biopsies from rheumatoid arthritis.
In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium.
Increased level of heme oxygenase-1 in rheumatoid arthritis synovial fluid.
Increased levels of matrix metalloproteinase-3 in sera from patients with active lupus nephritis.
Increased levels of matrix metalloproteinase-3 in the sera and synovial fluids of patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis: report of 2 cases.
Increased levels of serum matrix metalloproteinase-3 in haemodialysis patients with dialysis-related amyloidosis.
Increased levels of stromelysin-1 and tissue inhibitor of metalloproteinases-1 in sera from patients with rheumatoid arthritis.
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis.
Infliximab Induced a Dissociated Response of Severe Periodontal Biomarkers in Rheumatoid Arthritis Patients.
Infliximab reduces CD147, MMP-3, and MMP-9 expression in peripheral blood monocytes in patients with active rheumatoid arthritis.
Inhibitory Effect of a Novel Antirheumatic Drug T-614 on the IL-6-Induced RANKL/OPG, IL-17, and MMP-3 Expression in Synovial Fibroblasts from Rheumatoid Arthritis Patients.
Inhibitory Effects of IL-6-Mediated Matrix Metalloproteinase-3 and -13 by Achyranthes japonica Nakai Root in Osteoarthritis and Rheumatoid Arthritis Mice Models.
Interleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1.
Interleukin-16 in synovial fluids from cases of various types of arthritis.
Lack of association of matrix metalloproteinase-3 gene polymorphism with susceptibility to rheumatoid arthritis: a meta-analysis.
Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage.
Levels of circulating collagenase, stromelysin-1, and tissue inhibitor of matrix metalloproteinases 1 in patients with rheumatoid arthritis. Relationship to serum levels of antigenic keratan sulfate and systemic parameters of inflammation.
Levels of rheumatoid factor isotypes, metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in synovial fluid from various arthritides.
Levels of serum matrix metalloproteinase-3 correlate with disease activity in the enthesitis-related arthritis category of juvenile idiopathic arthritis.
Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption.
Macrophage migration inhibitory factor up-regulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis.
Matrix metalloproteinase-3 and the 7-joint ultrasound score in the assessment of disease activity and therapeutic efficacy in patients with moderate to severe rheumatoid arthritis.
Matrix metalloproteinase-3 gene polymorphism and its mRNA expression in rheumatoid arthritis.
Matrix metalloproteinase-3 in the central nervous system: a look on the bright side.
Matrix metalloproteinase-3 levels in relation to disease activity and radiological progression in rheumatoid arthritis.
Matrix Metalloproteinase-3 Producing Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Associated With Rheumatoid Arthritis.
Matrix metalloproteinase-3 serum levels are correlated with disease activity and predict clinical response in rheumatoid arthritis.
Matrix metalloproteinases MMP-3 and MMP-1 levels in sera and synovial fluids in patients with rheumatoid arthritis and osteoarthritis.
Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications.
Mechanism of action of celastrol against rheumatoid arthritis: A network pharmacology analysis.
Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression.
Messenger-RNA expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, and transcription factors in rheumatic synovial cells under mechanical stimuli.
Metalloprotease activity, phospholipase A2 activity and cytokine concentration in osteoarthritis synovial fluids.
MMP-3 expression and release by rheumatoid arthritis fibroblast-like synoviocytes induced with a bacterial ligand of integrin alpha5beta1.
MMP3 is a reliable marker for disease activity, radiological monitoring, disease outcome predictability, and therapeutic response in rheumatoid arthritis.
mu-Calpain is involved in the regulation of TNF-alpha-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line.
No increase in synovial fluid level of matrix metalloproteinase-3 by systemic administration of glucocorticoids in rheumatoid arthritis.
Normal serum matrix metalloproteinase-3 levels can be used to predict clinical remission and normal physical function in patients with rheumatoid arthritis.
Omentin concentrations are independently associated with those of matrix metalloproteinase-3 in patients with mild but not severe rheumatoid arthritis.
Pannus invasion and cartilage degradation in rheumatoid arthritis: involvement of MMP-3 and interleukin-1beta.
Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
Polymorphism in the stromelysin 1 (matrix metalloproteinase 3) promoter gene and severity of rheumatoid arthritis: comment on the article by Constantin et al.
Polymorphisms of MMP-1 and MMP-3 and susceptibility to rheumatoid arthritis. A meta-analysis.
Possible involvement of matrix metalloproteinase-3 in the pathogenesis of macroprolactinaemia in some patients with rheumatoid arthritis.
Possible role of shared epitope status in the relationship between matrix metalloproteinase 3 genotype and radiographic progression of rheumatoid arthritis: comment on the article by Constantin et al.
Prediction of Antiarthritic Drug Efficacies by Monitoring Active Matrix Metalloproteinase-3 (MMP-3) Levels in Collagen-Induced Arthritic Mice Using the MMP-3 Probe.
Production of anti-CCP antibodies and matrix metalloproteinase-3 by human rheumatoid arthritis synovial tissues using SCID mice.
Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B.
Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy.
Relationship between matrix metalloproteinase-3 serum level and pulmonary artery systolic pressure in patients with rheumatoid arthritis.
Relationship of epigenetic variability of miR-124 to extracellular matrix remodelling and age-related MMP-3 expression in rheumatoid arthritis.
Reply to: Comment on "Comparison of MMP-3 levels in rheumatoid arthritis after treatment with tocilizumab or infliximab for 12 weeks" by Yokoe et al.
Resveratrol inhibits TNF-?-induced IL-1?, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway.
Rheumatoid arthritis: MMP-3 levels predict 8-year joint damage.
S100A4 is expressed at site of invasion in rheumatoid arthritis synovium and modulates production of matrix metalloproteinases.
Serum levels of hyaluronan, antigenic keratan sulfate, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 change predictably in rheumatoid arthritis patients who have begun activity after a night of bed rest.
Serum Levels of Matrix Metalloproteinase (MMP) 9, a Risk Factor for Acute Coronary Syndrome, Are Reduced Independently of Serum MMP-3 by Anti-TNF-? Antibody (Infliximab) Therapy in Patients With Rheumatoid Arthritis.
Serum levels of matrix metalloproteinase 3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis.
Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study.
Serum levels of matrix metalloproteinase-3 in relation to the development of radiological damage in patients with early rheumatoid arthritis.
Serum matrix metalloproteinase 3 as a predictor of joint destruction in rheumatoid arthritis: comment on the article by Yamanaka et al.
Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis.
Serum matrix metalloproteinase 3 in early rheumatoid arthritis is correlated with disease activity and radiological progression.
Serum matrix metalloproteinase 3 levels are associated with an effect of iguratimod as add-on therapy to biological DMARDs in patients with rheumatoid arthritis.
Serum matrix metalloproteinase 3 levels during treatment with sulfasalazine or combination of methotrexate and sulfasalazine in patients with early rheumatoid arthritis.
Serum matrix metalloproteinase 3 levels in comparison to C-reactive protein in periods with and without progression of radiological damage in patients with early rheumatoid arthritis.
Serum matrix metalloproteinase-3 and fibrin degradation product levels correlate with clinical disease activity in rheumatoid arthritis.
Serum matrix metalloproteinase-3 as a noninvasive biomarker of histological synovitis for diagnosis of rheumatoid arthritis.
Serum matrix metalloproteinase-3 as predictor of joint destruction in rheumatoid arthritis, treated with non-biological disease modifying anti-rheumatic drugs.
Serum matrix metalloproteinase-3 in comparison with acute phase proteins as a marker of disease activity and radiographic damage in early rheumatoid arthritis.
Serum matrix metalloproteinase-3 in systemic sclerosis.
Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with early rheumatoid arthritis.
Serum metalloproteinases and their inhibitors: markers for malignant potential.
Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis.
Serum MMP-3 in rheumatoid arthritis: correlation with systemic inflammation but not with erosive status.
Serum pro-matrix metalloproteinase-3 as an indicator of disease activity and severity in rheumatoid arthritis: comparison with traditional markers.
Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis.
Steroid therapy and renal dysfunction are independently associated with serum levels of matrix metalloproteinase-3 in patients with rheumatoid arthritis.
Stromelysin (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase (TIMP-1) mRNA expression in scleritis.
Stromelysin 1 (matrix metalloproteinase 3) and HLA-DRB1 gene polymorphisms: Association with severity and progression of rheumatoid arthritis in a prospective study.
Stromelysin and tissue inhibitor of metalloproteinases gene expression in rheumatoid arthritis synovium.
Stromelysin synthesizing cells in the synovial tissues of rheumatoid arthritis demonstrated by in situ hybridization and immunohistochemical methods.
Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand.
Stromelysin-1 expression is activated in vivo by Ets-1 through palindromic head-to-head Ets binding sites present in the promoter.
Suppression of active, but not total MMP-3, is associated with treatment response in a phase III clinical study of rheumatoid arthritis.
Suppression of adjuvant arthritis of rats by a novel matrix metalloproteinase-inhibitor.
Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.
Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction.
Synergistic effect of glucosamine and vitamin E against experimental rheumatoid arthritis in neonatal rats.
Synovial MMP-3 and TIMP-1 levels and their correlation with cytokine expression in canine rheumatoid arthritis.
Synovial proinflammatory cytokines and their correlation with matrix metalloproteinase-3 expression in Behçet's disease. Does interleukin-1beta play a major role in Behçet's synovitis?
The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases.
The association of serum matrix metalloproteinases and their tissue inhibitor levels with scleroderma disease severity.
The diagnostic utility of anti-cyclic citrullinated peptide antibodies, matrix metalloproteinase-3, rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein in patients with erosive and non-erosive rheumatoid arthritis.
The diagnostic utility of matrix metalloproteinase-3 and high-sensitivity C-reactive protein for predicting rheumatoid arthritis in anti-cyclic citrullinated peptide antibody-negative patients with recent-onset undifferentiated arthritis.
The effects of leflunomide on clinical parameters and serum levels of IL-6, IL-10, MMP-1 and MMP-3 in patients with resistant rheumatoid arthritis.
The involvement of matrix metalloproteinases and inflammation in lumbar disc herniation.
The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3.
The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue.
Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.
Transin/stromelysin expression in rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes.
Treating to target matrix metalloproteinase 3 normalisation together with disease activity score below 2.6 yields better effects than each alone in rheumatoid arthritis patients: T-4 Study.
Variation in the matrix metalloproteinase-3, -7, -12 and -13 genes is associated with functional status in rheumatoid arthritis.
Weighting with the Lansbury articular index improves the correlation of ultrasound score with serum matrix metalloproteinase-3 level in rheumatoid arthritis patients.
[A basic study of determination matrix metalloproteinase-3 and carbohydrate in rheumatoid factor in serum for diagnosis of rheumatoid arthritis]
[Clinical significance of MMP-3 in patients with rheumatoid arthritis: comparison with other inflammatory markers(IL-6, IL-8)]
[Clinical value of serum matrix metalloproteinase-3 in evaluating joint destruction and therapeutic effect in rheumatoid arthritis patients].
[Correlations between serum matrix metalloproteinase (MMP-1, MMP-3, MMP-9, MMP-13) concentrations and markers of disease activity in early rheumatoid arthritis]
[Cytokines, prostaglandin E2, phospholipase A and metalloproteases in synovial fluid in osteoarthritis]
[Effects of TWEAK on the synthesis of MMP-3 in fibroblast-like synoviocytes of rheumatoid arthritis.]
[Efficacy of Hebi Formula Combined Methotrexate on Early Rheumatoid Arthritis Patients with Dis- harmony of Gan and Pi Syndrome and Its Effects on Serum MMP-3 and RANK/RANKL/OPG Expressions].
[Expression of matrix metalloproteinase-3 in patients with reheumatoid arthritis and its correlation with chronic periodontitis and rheumatoid arthritis].
[Immunological and serological tests for diagnosis of rheumatoid arthritis: MMP-3]
[Levels of matrix metalloproteinase-3 and urokinase-type plasminogen activator in knee synovial fluids from patients with rheumatoid arthritis and osteoarthritis]
[Matrix metalloproteinase (MMP)-3 is not effective for evaluating hemophilic arthropathy].
[MMP-3 as a Biomarker of Disease Activity of Rheumatoid Arthritis].
[Relationship between matrix metalloproteinase-3 levels and articular destructive changes in early and extended rheumatoid arthritis].
[Role of matrix metalloproteinase-3 in joint destruction in rheumatoid arthritis]
[Serum markers of synovitis and bone metabolism in rheumatoid arthritis]
[Significance of serum MMP-3, TIMP-1, and monocyte CD147 in rheumatoid arthritis patients of damp-heat Bi-syndrome and of cold-damp Bi-syndrome].
[Stromelysin-1 (MMP-3) level in the sera from patients with rheumatoid arthritis and other connective tissue diseases--clinical significances in early onset rheumatoid arthritis]
[Stromelysin-1 in inflammatory disease: significance, specificity, and regulation elements]
[The application of matrix metalloproteinase-3 and 7 joints ultrasonic score in assessment of disease activity in patients with rheumatoid arthritis].
[Usefulness of examinations of serum levels of matrix metalloproteinases 1, MMP-3, MMP-9, tissue inhibitor of metalloproteinases 1, hyaluronic acid and antibodies against cyclic citrullinated peptide in Lyme arthritis, rheumatoid arthritis and patients with arthritic complaints].
[Usefulness of serum matrix metalloproteinase-3(MMP-3) level in the diagnosis of rheumatoid arthritis]
[Value of serum matrix metalloproteinase 3 in the assessment of early rheumatoid arthritis].
[Value of serum matrix metalloproteinase-3 in the assessment of active disease in patients with rheumatoid arthritis].
Asthma
Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus.
Immunohistochemical localisation of the matrix metalloproteinases MMP-3 and MMP-9 within the airways in asthma.
Matrix metalloproteinase-3 in the central nervous system: a look on the bright side.
Relationship between matrix production by bronchial fibroblasts and lung function and AHR in asthma.
[Regulatory effects of inhaled steroids on expression of matrix metalloproteinase-9 and its inhibitor in asthmatic rats]
Astrocytoma
Expression of stromelysin 1 in human astrocytoma cell lines.
Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression.
Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China.
[Correlations of polymorphisms in matrix metalloproteinase-3 and -7 promoters to susceptibility to brain astrocytoma]
Atherosclerosis
A role for MMP-3 genetic variation in atherosclerosis susceptibility?
Activation of inflammatory mediators and potential role of ah-receptor ligands in foam cell formation.
Association of Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Variants with Ischemic Stroke and Its Subtype.
Association of matrix metalloproteinase-3 gene 5A/6A polymorphism with the recurrence of ischemic stroke: A prospective observational study.
Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis.
Association of the matrix metalloproteinase-3 (-439C/G) promoter polymorphism with Kawasaki disease in Korean children.
Correlations of MMP-1, MMP-3, and MMP-12 with the degree of atherosclerosis, plaque stability and cardiovascular and cerebrovascular events.
Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury.
Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis.
Enhanced cell cycle entry and mitogen-activated protein kinase-signaling and downregulation of matrix metalloproteinase-1 and -3 in human diabetic arterial vasculature.
Enhanced expression of matrix metalloproteinase-3, -12, and -13 mRNAs in the aortas of apolipoprotein E-deficient mice with advanced atherosclerosis.
Genetic contribution to carotid vascular disease in patients with systemic lupus erythematosus.
Genetic variation in human stromelysin gene promoter and common carotid geometry in healthy male subjects.
Genistein supplementation inhibits atherosclerosis with stabilization of the lesions in hypercholesterolemic rabbits.
Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study.
Haplotype Analysis of the Stromelysin-1 (MMP3) and Gelatinase B (MMP9) Genes in Relation to Coronary Heart Disease.
Lower serum concentration of matrix metalloproteinase-3 in the acute stage of myocardial infarction.
Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits.
Macrophages: an elusive yet emerging therapeutic target of atherosclerosis.
Matrix metalloproteinase-3 gene polymorphism (rs3025058) affects markers atherosclerosis in type 2 diabetes mellitus.
Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis.
Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 as potential markers of carotid atherosclerosis in infraclinical hyperlipidemia.
Serum matrix metalloproteinases MMP-2 and MMP-3 levels in dialysis patients vary independently of CRP and IL-6 levels.
Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis.
The Role of Matrix Metalloproteinase-3 In the Development of Atherosclerosis and Cardiovascular Events.
The role of matrix metalloproteinases in acute coronary syndromes.
The roles of stromelysin-1 and the gelatinase B gene polymorphism in stable angina.
Tissue inhibitor of matrix metalloproteinase-3 levels in the extracellular matrix of lung, kidney, and eye increase with age.
[Association between serum matrix metalloproteinase-3 concentration and the promoter 5A/6A polymorphism in patients with coronary heart disease]
[Establishment and analysis of chronic periodontitis and atherosclerosis model in Wistar rat]
Atrial Fibrillation
Effect of matrix metalloproteinase and their inhibitors on atrial myocardial structural remodeling.
MMP-1 and MMP-3 polymorphism and arrhythmia recurrence after electrical cardioversion in patients with persistent atrial fibrillation.
Autoimmune Diseases
Matrix metalloproteinase-3 in myasthenia gravis compared to other neurological disorders and healthy controls.
Axial Spondyloarthritis
ASDAS, BASDAI and different treatment responses and their relation to biomarkers of inflammation, cartilage and bone turnover in patients with axial spondyloarthritis treated with TNF? inhibitors.
Elevated Serum Levels of Sclerostin are Associated with High Disease Activity and Functional Impairment in Patients with Axial Spondyloarthritis.
Bacterial Infections
General and specific host responses to bacterial infection in Peyer's patches: a role for stromelysin-1 (matrix metalloproteinase-3) during Salmonella enterica infection.
Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice.
Basal Cell Nevus Syndrome
Increased expression of matrix metalloproteinase-3 (stromelysin-1) in cultured fibroblasts and basal cell carcinomas of nevoid basal cell carcinoma syndrome.
Bile Duct Neoplasms
Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
Biliary Atresia
High serum matrix metalloproteinase-3 and liver stiffness in postoperative biliary atresia.
Immunological investigation of the hepatic tissue from infants with biliary atresia.
Blister
Effects of matrix metalloproteinase-3 gene transfer by electroporation in glaucoma filter surgery.
Enhanced expression of interstitial collagenase, stromelysin-1, and urokinase plasminogen activator in lesions of dermatitis herpetiformis.
Gene expression of collagenase and stromelysin in skin fibroblasts derived from dystrophic epidermolysis bullosa.
Increased gene expression of matrix metalloproteinase-3 (stromelysin) in skin fibroblasts from patients with severe recessive dystrophic epidermolysis bullosa.
Matrix metalloproteinases (MMP-1, MMP-2, MMP-3 and MMP-9, and TIMP-1, TIMP-2 and TIMP-3) and markers for vascularization in functioning and non-functioning bleb capsules of glaucoma drainage implants.
Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis.
Photosensitization of uroporphyrin augments the ultraviolet A-induced synthesis of matrix metalloproteinases in human dermal fibroblasts.
Urokinase plasminogen activator is expressed by basal keratinocytes before interstitial collagenase, stromelysin-1, and laminin-5 in experimentally induced dermatitis herpetiformis lesions.
Bone Resorption
3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease.
Differential regulation of MMP-13 (collagenase-3) and MMP-3 (stromelysin-1) in mouse calvariae.
Effects of BI 655064, an antagonistic anti-CD40 antibody, on clinical and biomarker variables in patients with active rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase IIa study.
Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis.
Mice Deficient in CIZ/NMP4 Develop an Attenuated Form of K/BxN-Serum Induced Arthritis.
MMP-3 response to compressive forces in vitro and in vivo.
Osteoporosis in rheumatoid arthritis: a molecular biological aspect of connective tissue gene activation.
Postmenopausal women with rheumatoid arthritis who are treated with raloxifene or alendronate or glucocorticoids have lower serum undercarboxylated osteocalcin (ucOC) levels.
PP121 suppresses RANKL-Induced osteoclast formation in vitro and LPS-Induced bone resorption in vivo.
Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a substudy of the multicenter double-blind, placebo-controlled trial of tocilizumab in inadequate responders to methotrexate alone.
Brain Contusion
Study on changes of MMP-3 expression after brain contusion in rats.
[Expression of matrix metalloproteinase-3 after brain contusion in rats]
Brain Diseases
Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia.
Brain Injuries
Peroxynitrite-Induced Tyrosine Nitration Contributes to Matrix Metalloprotease-3 Activation: Relevance to Hyperglycemic Ischemic Brain Injury and Tissue Plasminogen Activator.
Brain Injuries, Traumatic
Agrin expression during synaptogenesis induced by traumatic brain injury.
Elevation of hippocampal MMP-3 expression and activity during trauma-induced synaptogenesis.
Matrix metalloproteinase-3 expression profile differentiates adaptive and maladaptive synaptic plasticity induced by traumatic brain injury.
Multi-Potent Adult Progenitor Cells, but not Tissue Inhibitor of Matrix Metalloproteinase-3, Increase Tissue Sparing and Reduce Urological Complications following Spinal Cord Injury.
Brain Ischemia
Stromelysin-1 and gelatinase A are upregulated before TNF-alpha in LPS-stimulated neuroinflammation.
Brain Neoplasms
Expression of stromelysin 1 in human astrocytoma cell lines.
Production of matrix metalloproteinases and tissue inhibitor of metalloproteinases-1 by human brain tumors.
Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines.
Breast Diseases
Inhibition of human MDA-MB-231 breast cancer cell invasion by matrix metalloproteinase 3 involves degradation of plasminogen.
Breast Neoplasms
A molecular basis for the selectivity of thiadiazole urea inhibitors with stromelysin-1 and gelatinase-A from generalized born molecular dynamics simulations.
A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility.
Anesthetic technique and the cytokine and matrix metalloproteinase response to primary breast cancer surgery.
Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/?-Catenin Signaling.
Cancer cell-derived interleukin 1alpha contributes to autocrine and paracrine induction of pro-metastatic genes in breast cancer.
CXCR7 protein expression correlates with elevated mmp-3 secretion in breast cancer cells.
Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines.
Elucidating cancer-vascular paracrine signaling using a human organotypic breast cancer cell extravasation model.
Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells.
Evaluation of P1'-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11.
Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development.
Expression of c-ets-1 mRNA is associated with an invasive, EMT-derived phenotype in breast carcinoma cell lines.
Expression of proteinases and inhibitors in human breast cancer progression and survival.
Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.
Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer.
Human cytomegalovirus interleukin-10 enhances matrigel invasion of MDA-MB-231 breast cancer cells.
Immunohistochemical localization of metallothionein in human breast cancer in comparison with cathepsin D, stromelysin-1, CD44, extracellular matrix components, P53, Rb, C-erbB-2, EGFR, steroid receptor content and proliferation.
Immunolocalization of matrix metallo-proteinases and their tissue inhibitor in human mammary pathology.
In vitro and in vivo MMP gene expression localisation by In Situ-RT-PCR in cell culture and paraffin embedded human breast cancer cell line xenografts.
Inhibition of breast cancer growth and invasion by single-minded 2s.
Inhibition of human MDA-MB-231 breast cancer cell invasion by matrix metalloproteinase 3 involves degradation of plasminogen.
Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids.
Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion.
Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array.
Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1.
Matrix metalloproteinase (MMP)-1 and MMP-3 gene variations affect MMP-1 and -3 serum concentration and associates with breast cancer.
Matrix metalloproteinase expression in human breast cancer: an immunohistochemical study including correlation with cathepsin D, type IV collagen, laminin, fibronectin, EGFR, c-erbB-2 oncoprotein, p53, steroid receptors status and proliferative indices.
Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material.
Matrix metalloproteinase single-nucleotide polymorphisms and haplotypes predict breast cancer progression.
Matrix metalloproteinase-1 and -3 in breast cancer: correlation with progesterone receptors and other clinicopathologic features.
Matrix metalloproteinases and metastatic cancer.
Metalloproteinases 1 and 3 as Potential Biomarkers in Breast Cancer Development.
No association between matrix metalloproteinase-1 or matrix metalloproteinase-3 polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study.
Novel effects of sphingosylphosphorylcholine on invasion of breast cancer: Involvement of matrix metalloproteinase-3 secretion leading to WNT activation.
Overexpression of MMP-3 and uPA with Diminished PAI-1 Related to Metastasis in Ductal Breast Cancer Patients Attending a Public Hospital in Mexico City.
Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas.
Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer.
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability.
Retinoids interfere with the AP1 signalling pathway in human breast cancer cells.
Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2.
Spontaneous metastasis in matrix metalloproteinase 3-deficient mice.
Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer.
The 5A/6A polymorphism of the matrix metalloproteinase 3 gene promoter and breast cancer.
The inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells.
Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.
[The expression of MMPs and TIMPs in human breast cancer tissues and importance of their balance in cancer invasion and metastasis]
Bronchiolitis
Proteins involved in extracellular matrix dynamics are associated with RSV disease severity.
Bronchiolitis Obliterans
Proteomic characterization reveals that MMP-3 correlates with bronchiolitis obliterans syndrome following allogeneic hematopoietic cell and lung transplantation.
Bronchopulmonary Dysplasia
Bronchoalveolar lavage fluid peptidomics suggests a possible matrix metalloproteinase-3 role in bronchopulmonary dysplasia.
Bursitis
A Study of IL-1?, MMP-3, TGF-?1, and GDF5 Polymorphisms and Their Association with Primary Frozen Shoulder in a Chinese Han Population.
Association of MMP3 genotype with susceptibility to frozen shoulder: a case-control study in a Chinese Han population.
Carcinogenesis
A protective role for matrix metalloproteinase-3 in squamous cell carcinoma.
A study on angiogenesis-related matrix metalloproteinase networks in primary hepatocellular carcinoma.
A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression.
Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori-positive and Helicobacter pylori-negative gastritis.
Association of -1171 promoter polymorphism of matrix metalloproteinase-3 with increased risk for oral cancer.
Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis.
Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis.
Expression of stromelysin-1 and TIMP-1 in the involuting mammary gland and in early invasive tumors of the mouse.
Induction of the putative protective protein ferritin by infrared radiation: implications in skin repair.
Matrix-degrading metalloproteinases in tumor progression.
Spontaneous metastasis in matrix metalloproteinase 3-deficient mice.
Stromelysin in tumor progression and metastasis.
The 5A/6A polymorphism of the matrix metalloproteinase 3 gene promoter and breast cancer.
The role of matrix metalloproteinases in acute coronary syndromes.
WNT-5A, but not matrix metalloproteinase 3 or beta-catenin protein, expression is related to early stages of lip carcinogenesis.
Carcinoma
A protective role for matrix metalloproteinase-3 in squamous cell carcinoma.
A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression.
alpha1 and alpha2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression.
Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.
Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma.
Autocrine and paracrine regulation of tissue inhibitor of metalloproteinases, transin, and urokinase gene expression in metastatic and nonmetastatic mammary carcinoma cells.
Cancer-Specific Survival Stratification Derived from Tumor Expression of Tissue Inhibitor of Metalloproteinase-2 in Non-Metastatic Renal Cell Carcinoma.
Changes in the expression of matrix proteases and of the transcription factor c-Ets-1 during progression of precancerous bronchial lesions.
Comparative analysis of immunohistochemical markers with invasiveness and histologic differentiation in squamous cell carcinoma and basal cell carcinoma of the skin.
Constitutive expression and secretion of proteases in non-metastatic SP1 mammary carcinoma cells and its metastatic sublines.
Cyr61 increases matrix metalloproteinase-3 expression and cell motility in human oral squamous cell carcinoma cells.
Detection of mRNAs encoding collagenase I and stromelysin 2 in carcinomas of the head and neck by in situ hybridization.
Development of recombinant matrix metalloproteinase-3 based sandwich ELISA for sero-diagnosis of canine mammary carcinomas.
Differential expression of MMP and uPA systems and prognostic relevance of their expression in esophageal squamous cell carcinoma.
Effect of tumor-associated mutant E-cadherin variants with defects in exons 8 or 9 on matrix metalloproteinase 3.
Elevation of serum levels of matrix metalloproteinase-2 and -3 as new predictors of recurrence in patients with urothelial carcinoma.
Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma.
Enhanced production of matrix metalloproteinases and activation of matrix metalloproteinase 2 (gelatinase A) in human gastric carcinomas.
Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis.
Expression and localization of the matrix metalloproteinase pump-1 (MMP-7) in human gastric and colon carcinomas.
Expression of ?v?6 integrin and collagen fibre in oral squamous cell carcinoma: association with clinical outcomes and prognostic implications.
Expression of collagenase-related metalloproteinase genes in human lung or head and neck tumours.
Expression of ets-1 transcription factor in human head and neck squamous cell carcinoma and effect of histamine on metastatic potential of invasive tumor through the regulation of expression of ets-1 and matrix metalloproteinase-3.
Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis.
Expression of matrix metalloproteinase-3 in stage I and II squamous cell carcinoma of the oral cavity.
Expression of MMP-3, MMP-13, TIMP-2 and TIMP-3 in the VX2 carcinoma of the New Zealand white rabbit.
Expression of stromelysin 3 in the stromal elements of human basal cell carcinoma.
Expression of urokinase-type plasminogen activator, stromelysin 1, stromelysin 3, and matrilysin genes in lung carcinomas.
Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression.
Gene expression of matrix metalloproteinase-1 (interstitial collagenase) and matrix metalloproteinase-3 (stromelysin-1) in basal cell carcinoma by in situ hybridization using chondroitin ABC lyase.
Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer.
Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89.
Identification of a metalloproteinase co-purifying with rat tumour collagenase and the characteristics of fragments of both enzymes.
Increased expression of matrix metalloproteinase-3 (stromelysin-1) in cultured fibroblasts and basal cell carcinomas of nevoid basal cell carcinoma syndrome.
Interactions of alpha2-HS-glycoprotein (fetuin) with MMP-3 and murine squamous cell carcinoma cells.
Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption.
Mammary carcinoma in aged gerbil mothers after endocrine disruption in pregnancy and lactation.
Matrix metalloproteinase 3 polymorphism: a predictive factor of response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma.
Matrix metalloproteinase-1 and -3 in breast cancer: correlation with progesterone receptors and other clinicopathologic features.
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in bronchial squamous preinvasive lesions.
Matrix-degrading metalloproteinases in tumor progression.
Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression.
MMP-3 mRNA and MMP-3 and MMP-1 proteins in bladder cancer: a comparison with clinicopathologic features and survival.
mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas.
NFAT1 promotes cell motility through MMP-3 in esophageal squamous cell carcinoma.
Production of matrix metalloproteinase-2 and metalloproteinase-3 related to malignant behavior of esophageal carcinoma. A clinicopathologic study.
Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas.
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability.
Requirement of MMP-3 in anchorage-independent growth of oral squamous cell carcinomas.
Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma
Serum and Saliva MMP-3 in Patients with OLP and Oral SCC.
Signal transducer and activator of transcription 1 and matrix metalloproteinase 3 genetic expression and clinical significance on urothelial tumors after renal transplantation.
Stromelysin-1 activation correlates with invasiveness in squamous cell carcinoma.
The 2G allele of promoter region of Matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma.
The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinoma.
The inhibitor of kappa B kinase-epsilon regulates MMP-3 expression levels and can promote lung metastasis.
The malignant conversion step of mouse skin carcinogenesis.
The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.
The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas.
The significance of epidermal growth factor receptor and matrix metalloproteinase-3 in squamous cell carcinoma of the oral cavity.
Transcriptional modulation of transin gene expression by epidermal growth factor and transforming growth factor beta.
Upregulation of serum vascular endothelial growth factor and matrix metalloproteinase-3 in patients with oral squamous cell carcinoma.
[Detection of stromelysin mRNA expression in human hepatocellular carcinoma by in situ hybridization]
[Study of the expression of nuclear factor-kappa B, matrix metalloproteinase-3, -9 on nasopharygeal carcinoma and their clinical significance].
Carcinoma in Situ
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in bronchial squamous preinvasive lesions.
Carcinoma, Basal Cell
Comparative analysis of immunohistochemical markers with invasiveness and histologic differentiation in squamous cell carcinoma and basal cell carcinoma of the skin.
Expression of stromelysin 3 in the stromal elements of human basal cell carcinoma.
Gene expression of matrix metalloproteinase-1 (interstitial collagenase) and matrix metalloproteinase-3 (stromelysin-1) in basal cell carcinoma by in situ hybridization using chondroitin ABC lyase.
Increased expression of matrix metalloproteinase-3 (stromelysin-1) in cultured fibroblasts and basal cell carcinomas of nevoid basal cell carcinoma syndrome.
Carcinoma, Ductal
Matrix metalloproteinase-1 and -3 in breast cancer: correlation with progesterone receptors and other clinicopathologic features.
Carcinoma, Hepatocellular
AMF/PGI transactivates the MMP-3 gene through the activation of Src-RhoA-phosphatidylinositol 3-kinase signaling to induce hepatoma cell migration.
Association of E-cadherin, matrix metalloproteinases, and tissue inhibitors of metalloproteinases with the progression and metastasis of hepatocellular carcinoma.
Expression of matrix metalloproiteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in hepatocellular carcinoma tissue, compared with the surrounding non-tumor tissue.
Expression of the transin, c-fos, and c-jun genes in rat transplantable osteosarcomas and malignant fibrous histiocytomas.
Expression pattern of matrix metalloproteinases in human liver.
Functional polymorphisms in the promoters of MMP-1, MMP-2, MMP-3, MMP-9, MMP-12 and MMP-13 are not associated with hepatocellular carcinoma risk.
Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3.
Immunocytochemical detection of MMP-3 and -10 expression in hepatocellular carcinomas.
Induction of hepatoma cells migration by phosphoglucose isomerase/autocrine motility factor through the upregulation of matrix metalloproteinase-3.
No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population.
Serum matrix metalloproteinase-3 (stromelysin-1) concentration in patients with chronic liver disease.
The genotypes of IL-1 beta and MMP-3 are associated with the prognosis of HCV-related hepatocellular carcinoma.
[Detection of stromelysin mRNA expression in human hepatocellular carcinoma by in situ hybridization]
Carcinoma, Intraductal, Noninfiltrating
Comedo-ductal carcinoma in situ: A paradoxical role for programmed cell death.
Carcinoma, Medullary
Matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases and angiogenic cytokines in peripheral blood of patients with thyroid cancer.
Matrix-metalloproteinases 1, 2, and 3 and their tissue inhibitors 1 and 2 in benign and malignant breast lesions: an in situ hybridization study.
Carcinoma, Non-Small-Cell Lung
Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance.
The VEGFR2, COX-2 and MMP-2 polymorphisms are associated with clinical outcome of patients with inoperable non-small cell lung cancer.
[Correlation of matrix metalloproteinase-3 polymorphism to genetic susceptibility and lymph node metastasis of non-small cell lung cancer]
Carcinoma, Renal Cell
Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.
Cancer-Specific Survival Stratification Derived from Tumor Expression of Tissue Inhibitor of Metalloproteinase-2 in Non-Metastatic Renal Cell Carcinoma.
mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas.
Carcinoma, Squamous Cell
A protective role for matrix metalloproteinase-3 in squamous cell carcinoma.
Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma.
Comparative analysis of immunohistochemical markers with invasiveness and histologic differentiation in squamous cell carcinoma and basal cell carcinoma of the skin.
Expression of ets-1 transcription factor in human head and neck squamous cell carcinoma and effect of histamine on metastatic potential of invasive tumor through the regulation of expression of ets-1 and matrix metalloproteinase-3.
Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis.
Expression of matrix metalloproteinase-3 in stage I and II squamous cell carcinoma of the oral cavity.
Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression.
Interactions of alpha2-HS-glycoprotein (fetuin) with MMP-3 and murine squamous cell carcinoma cells.
Matrix metalloproteinase 3 polymorphism: a predictive factor of response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma.
Matrix-degrading metalloproteinases in tumor progression.
Production of matrix metalloproteinase-2 and metalloproteinase-3 related to malignant behavior of esophageal carcinoma. A clinicopathologic study.
Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma
Stromelysin-1 activation correlates with invasiveness in squamous cell carcinoma.
The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.
The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas.
The significance of epidermal growth factor receptor and matrix metalloproteinase-3 in squamous cell carcinoma of the oral cavity.
[Correlation of matrix metalloproteinase-3 polymorphism to genetic susceptibility and lymph node metastasis of non-small cell lung cancer]
Cardiomyopathies
Comparison of levels of matrix metalloproteinase-2 and -3 in patients with ischemic cardiomyopathy versus nonischemic cardiomyopathy.
Prognostic impact of matrix metalloproteinase gene polymorphisms in patients with heart failure according to the aetiology of left ventricular systolic dysfunction.
Cardiomyopathy, Dilated
Comparison of levels of matrix metalloproteinase-2 and -3 in patients with ischemic cardiomyopathy versus nonischemic cardiomyopathy.
Serum matrix metalloproteinase-3 as a novel marker for risk stratification of patients with nonischemic dilated cardiomyopathy.
Cardiovascular Diseases
Anti-apolipoprotein A-1 IgG predicts major cardiovascular events in patients with rheumatoid arthritis.
Functional polymorphisms in matrix metalloproteinases-1, -3, -9 are associated with arteriovenous fistula patency in hemodialysis patients.
Genetic contribution to carotid vascular disease in patients with systemic lupus erythematosus.
Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling.
Carotid Artery Diseases
Association of blood active matrix metalloproteinase-3 with carotid plaque score from a community population in Taiwan.
Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis.
Correlations of MMP-1, MMP-3, and MMP-12 with the degree of atherosclerosis, plaque stability and cardiovascular and cerebrovascular events.
Matrix metalloproteinase-3 gene polymorphism (rs3025058) affects markers atherosclerosis in type 2 diabetes mellitus.
Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 as potential markers of carotid atherosclerosis in infraclinical hyperlipidemia.
Carotid Stenosis
Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis.
Cataract
Correlations Between MMPs and TIMPs Levels in Aqueous Humor from High Myopia and Cataract Patients.
Human aqueous humor levels of transforming growth factor-?2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases.
MMP-2, MMP-3, TIMP-1, TIMP-2, and TIMP-3 protein levels in human aqueous humor: relationship with axial length.
The role of oxidative stress and inflammation in conjunctivochalasis.
[Effects of matrix metalloproteinase-3, osteopontin, and tissue inhibitor of metalloproteinase-1 in the formation of cataract]
Celiac Disease
Association of the matrix metalloproteinase-3 (MMP-3) promoter polymorphism with celiac disease in male subjects.
Cell Transformation, Neoplastic
Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing.
Central Nervous System Infections
Neurotrophic factor levels in the serum and cerebrospinal fluid of neonates infected with human cytomegalovirus.
Cerebellar Ataxia
Exclusion of stromelysin-1, stromelysin-2, interstitial collagenase and fibronectin genes as the mutant loci in a family with recessive epidermolysis bullosa dystrophica and a form of cerebellar ataxia.
Cerebral Infarction
White matter damage is associated with matrix metalloproteinases in vascular dementia.
[Association of matrix metalloproteinase-3 serum level and the promoter 5A/6A polymorphism of the MMP-3 gene with atherosclerotic cerebral infarction]
Cholangiocarcinoma
Association of matrix metalloproteinase-1 and -3 promoter polymorphisms with clinical subsets of Norwegian primary sclerosing cholangitis patients.
Cholangitis, Sclerosing
A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis.
Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis.
Cholera
Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.
Cholesteatoma
Detection of macrophage migration inhibitory factor (MIF) in human cholesteatomas and functional implications of correlations to recurrence status and to expression of matrix metalloproteinases-3/9, retinoic acid receptor-beta, and anti-apoptotic galectin-3.
Expression of matrix-metalloproteinases and their inhibitors in human cholesteatomas.
Chondrocalcinosis
Clinical, radiological, and biochemical characteristics in patients with diseases mimicking polymyalgia rheumatica.
Low prevalence of knee chondrocalcinosis and its catabolic association by use of serum matrix metalloproteinase 3: A rural Japanese population study.
MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis.
Chondrosarcoma
Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells.
Chondroprotective effects of glucosamine involving the p38 MAPK and Akt signaling pathways.
Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression.
Expression of MMP-9 decreases metastatic potential of Chondrosarcoma: an immunohistochemical study.
Human chondrosarcoma cells stably transfected with a stromelysin (MMP-3) promoter reporter construct provide a method of assessing transcriptional inhibitors.
Immunohistochemical analysis of matrix metalloproteinase-1, -3, and -13 in naturally occurring cartilaginous tumors of dogs.
Immunolocalization of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas.
In vitro suppression of the MMP-3 gene in normal and cytokine-treated human chondrosarcoma using small interfering RNA.
Involvement of matrix metalloproteinase-3 in CCL5/CCR5 pathway of chondrosarcomas metastasis.
Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes.
Roxatidine Attenuates Degradation of Extracellular Matrix.
Choriocarcinoma
Matrix metalloproteinases and their inhibitors in gestational trophoblastic diseases and normal placenta.
Chronic Periodontitis
Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis.
CD40 engagement modulates the production of matrix metalloproteinases by gingival fibroblasts.
Cytokine and metalloproteinases in gingival fluid from patients with chronic periodontitis.
Effect of phase 1 periodontal therapy on gingival crevicular fluid levels of matrix metalloproteinases-3 and -13 in chronic periodontitis patients.
Genetic polymorphisms in the MMP-1 and MMP-3 gene may contribute to chronic periodontitis in a Brazilian population.
Gingival Tissue and Crevicular Fluid Co-operation in Adult Periodontitis.
Immunohistochemical study of neutrophil- and fibroblast-type collagenases and stromelysin-1 in adult periodontitis.
Pathogen profile and MMP-3 levels in areas with varied attachment loss in generalized aggressive and chronic periodontitis.
[Expression of matrix metalloproteinase-3 in patients with reheumatoid arthritis and its correlation with chronic periodontitis and rheumatoid arthritis].
[Expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model]
Colitis
Increased Expression of Matrix Metalloproteinase-1 and 3 in Remission Patients of Steroid-Dependent Ulcerative Colitis.
Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon.
Therapeutic implications of the specific inhibition of causative matrix metalloproteinases in experimental colitis induced by dextran sulphate sodium.
Colitis, Ulcerative
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease.
Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intestine.
Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers.
Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease.
Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease.
Leucine-rich alpha-2 glycoprotein 1, high mobility group box 1, matrix metalloproteinase 3 and annexin A1 as biomarkers of ulcerative colitis endoscopic and histological activity.
Metalloproteinase-3 and -9 as novel markers in the evaluation of ulcerative colitis activity in children.
P088. Serum matrix metalloproteinase-3 concentration correlates with clinical and endoscopic evidence of ulcerative colitis.
Phenotype of cells expressing matrix metalloproteinase-3 in ulcerative colitis.
Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis.
Role of macrophage metalloelastase in gut inflammation.
Colitis-Associated Neoplasms
Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-? and bradykinin in human colonic myofibroblasts.
Colonic Neoplasms
Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models.
Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor.
EFEMP2 promotes colon cancer cell invasion and growth through the ERK1/2 signaling pathway.
Glycine-extended gastrin induces matrix metalloproteinase-1- and -3-mediated invasion of human colon cancer cells through type I collagen gel and Matrigel.
Matrix-degrading metalloproteinases in tumor progression.
Simultaneous determination of matrix metalloproteinase (MMP)-7, MMP-1, -3, and -13 gene expression by multiplex PCR in colorectal carcinomas.
Small integrin binding ligand N-linked glycoprotein gene family expression in different cancers.
Colorectal Neoplasms
Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer.
Differential Wnt pathway gene expression and E-cadherin truncation in sporadic colorectal cancers with and without microsatellite instability.
Expression and localization of matrix metalloproteinases and tissue inhibitors of metalloproteinases as a prognostic factor in advanced colorectal carcinomas.
Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer.
Impairment of stromelysin-1 transcriptional activity by promoter mutations in high microsatellite instability colorectal tumors.
Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing.
Matrix metalloproteinase-9,-3 and tissue inhibitor of matrix metalloproteinase-1 in colorectal cancer: relationship to clinicopathological variables.
Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
Matrix metalloproteinases, their tissue inhibitors and colorectal cancer staging.
Minimally invasive colorectal resection is associated with significantly elevated levels of plasma matrix metalloproteinase 3 (MMP-3) during the first month after surgery which may promote the growth of residual metastases.
No association between the polymorphisms in matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter regions and colorectal cancer in chinese.
Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice.
Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.
Role of matrix metalloproteinases (MMPs) in colorectal cancer.
Significance of coexpression of urokinase-type plasminogen activator, and matrix metalloproteinase 3 (stromelysin) and 9 (gelatinase B) in colorectal carcinoma.
Simultaneous determination of matrix metalloproteinase (MMP)-7, MMP-1, -3, and -13 gene expression by multiplex PCR in colorectal carcinomas.
Stromelysin-1 promoter mutations impair gelatinase B activation in high microsatellite instability sporadic colorectal tumors.
The distribution of matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal cancer.
The stromelysin-1 5A/5A genotype enhances colorectal cancer cell invasion in Iranian population.
[Polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 in colorectal cancer]
Communicable Diseases
Differential expression of matrix metalloproteinases in bacterial meningitis.
Congenital Abnormalities
Imbalanced MMP-3 and MMP-12 serum levels in systemic lupus erythematosus patients with Jaccoud's arthropathy and a distinctive MRI pattern.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B.
Connective Tissue Diseases
Elevated plasma stromelysin levels in arthritis.
[Stromelysin-1 (MMP-3) level in the sera from patients with rheumatoid arthritis and other connective tissue diseases--clinical significances in early onset rheumatoid arthritis]
Contracture
Inducement of mitogen-activated protein kinases in frozen shoulders.
Corneal Opacity
An intact complement system dampens cornea inflammation during acute primary HSV-1 infection.
Coronary Aneurysm
Association of the matrix metalloproteinase-3 (-439C/G) promoter polymorphism with Kawasaki disease in Korean children.
Elevated levels of matrix metalloprotein-3 in patients with coronary aneurysm: A case control study.
Coronary Artery Disease
Association between MMP-3 and MMP-9 polymorphisms and coronary artery disease.
Association of MMP-1 (rs1799750)-1607 2G/2G and MMP-3 (rs3025058)-1612 6A/6A genotypes with coronary artery disease risk among Iranian Turks.
Circulating matrix metalloproteinase 3 due to myocardial ischemia.
Combined impact of matrix metalloproteinase-3 and paraoxonase 1 55/192 gene variants on coronary artery disease in Turkish patients.
Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis.
Elevated levels of matrix metalloprotein-3 in patients with coronary aneurysm: A case control study.
Genetic variation in human stromelysin gene promoter and common carotid geometry in healthy male subjects.
Genotype-phenotype association of matrix metalloproteinase-3 polymorphism and its synergistic effect with smoking on the occurrence of acute coronary syndrome.
Induction of stromelysin-1 (MMP-3) by fibroblast growth factor-2 (FGF-2) in FGF-2-/- microvascular endothelial cells requires prolonged activation of extracellular signal-regulated kinases-1 and -2 (ERK-1/2).
Influence of genetic polymorphism in matrix metalloproteinase-3 on extent of coronary atherosclerosis and risk of coronary artery stenosis.
Influences of matrix metalloproteinase-3 gene variation on extent of coronary atherosclerosis and risk of myocardial infarction.
Large artery stiffness: structural and genetic aspects.
Matrix metalloproteinase-3 (MMP-3) -1612 5A/6A promoter polymorphism in coronary artery disease in Indian population.
Matrix metalloproteinase-3 gene polymorphism (rs3025058) affects markers atherosclerosis in type 2 diabetes mellitus.
Matrix metalloproteinase-3 predicts clinical cardiovascular outcomes in patients with coronary artery disease: a 5 years cohort study.
Plasma matrix metalloproteinase-3 level is an independent prognostic factor in stable coronary artery disease.
Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease.
Potential role of selected biomarkers for predicting the presence and extent of coronary artery disease.
Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis.
Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression.
Relationship of blood levels of inflammatory and destructive biomarkers in coronary atherosclerosis with long-term results of surgical revascularization.
Serum matrix metalloproteinase-3 concentration is influenced by MMP-3 -1612 5A/6A promoter genotype and associated with myocardial infarction.
Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis.
The 5A/6A polymorphism in the promoter of the stromelysin-1 (MMP-3) gene predicts progression of angiographically determined coronary artery disease in men in the LOCAT gemfibrozil study. Lopid Coronary Angiography Trial.
The roles of stromelysin-1 and the gelatinase B gene polymorphism in stable angina.
The stromelysin-1 (MMP-3) gene and risk of coronary artery disease: a candidate gene that has won the election?
The stromelysin-1 5A/6A promoter polymorphism is a disease marker for the extent of coronary heart disease.
Variation in the matrix metalloproteinase-1 gene and risk of coronary heart disease.
[Association between single nucleotide polymorphisms of matrix metalloproteinase-3 gene and the severity of coronary atherosclerosis in patients with coronary artery disease]
Coronary Disease
Haplotype Analysis of the Stromelysin-1 (MMP3) and Gelatinase B (MMP9) Genes in Relation to Coronary Heart Disease.
Haplotypes and 5A/6A polymorphism of the matrix metalloproteinase-3 gene in coronary disease: Case-control study and a meta-analysis.
Interaction between smoking and the stromelysin-1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men.
Matrix metalloproteinase-3 and coronary remodelling: implications for unstable coronary disease.
Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression.
The stromelysin-1 5A/6A promoter polymorphism is a disease marker for the extent of coronary heart disease.
Variation in the matrix metalloproteinase-1 gene and risk of coronary heart disease.
[Assessment of the role of matrix metalloproteinase-3 gene polymorphism in the development of chronic heart failure].
[Association between serum matrix metalloproteinase-3 concentration and the promoter 5A/6A polymorphism in patients with coronary heart disease]
Coronary Stenosis
Influence of genetic polymorphism in matrix metalloproteinase-3 on extent of coronary atherosclerosis and risk of coronary artery stenosis.
Matrix metalloproteinase-3 and coronary remodelling: implications for unstable coronary disease.
Risk of coronary artery stenosis in Iranian type 2 diabetics: is there a role for matrix metalloproteinase-3 gene (-1612 5A/6A) polymorphism?
COVID-19
Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1).
Matrix metalloproteinase 3 as a valuable marker for patients with COVID-19.
Matrix metalloproteinases are involved in the development of neurological complications in patients with Coronavirus disease 2019.
Crohn Disease
Correlation of MMP-3 and MMP-9 with Crohn's Disease Activity in Children.
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease.
Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intestine.
Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers.
Expression and localisation of matrix metalloproteinases and their natural inhibitors in fistulae of patients with Crohn's disease.
Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease.
Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease.
Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease.
Role of macrophage metalloelastase in gut inflammation.
Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohn's disease patients treated with infliximab.
Transmission disequilibrium test of stromelysin-1 gene variation in relation to Crohn's disease.
Crystal Arthropathies
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
Cutis Laxa
Cutis Laxa: analysis of metalloproteinases and extracellular matrix expression by immunohistochemistry and histochemistry.
Regulation of matrix metalloproteinase (MMP) expression in cutis laxa fibroblasts: upregulation of MMP-1, MMP-3 and MMP-9 genes but not of the MMP-2 gene.
Dementia
Concentrations of Matrix Metalloproteinases and their Tissue Inhibitors in the Cerebrospinal Fluid of Patients with Alzheimer's Disease.
Impact of the matrix metalloproteinase MMP-3 on dementia.
Matrix metalloproteinase 3 haplotypes and dementia and Alzheimer's disease. The Rotterdam Study.
Demyelinating Diseases
Matrix metalloproteinase-12 deficiency ameliorates the clinical course and demyelination in Theiler's murine encephalomyelitis.
MMP-12, MMP-3, and TIMP-1 are markedly upregulated in chronic demyelinating theiler murine encephalomyelitis.
The up-regulation of stromelysin-1 (MMP-3) in a spontaneously demyelinating transgenic mouse precedes onset of disease.
Dermatitis
Expression of matrix metalloproteinases (MMP-2, MMP-3, and MMP-9) and fibronectin in lichen planus.
Dermatitis Herpetiformis
Enhanced expression of interstitial collagenase, stromelysin-1, and urokinase plasminogen activator in lesions of dermatitis herpetiformis.
Urokinase plasminogen activator is expressed by basal keratinocytes before interstitial collagenase, stromelysin-1, and laminin-5 in experimentally induced dermatitis herpetiformis lesions.
Dermatitis, Atopic
Increased levels of serum tissue inhibitor of metalloproteinase-1 but not metalloproteinase-3 in atopic dermatitis.
Dermatitis, Contact
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response.
Dermatomyositis
Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis.
Expression of matrix metalloproteinases in the muscle of patients with inflammatory myopathies.
Diabetes Complications
Comparison of Serum Pharmacodynamic Biomarkers in Prednisone-Versus Deflazacort-Treated Duchenne Muscular Dystrophy Boys.
Diabetes Mellitus
Association Between Matrix Metalloproteinase-3 Activity and Glomerular Filtration Rate and Albuminuria Status in Patients With Type 2 Diabetes Mellitus.
Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development.
Genetic risk and gene-environment interaction in coronary artery spasm in Japanese men and women.
Matrix metalloproteinase-3 gene polymorphism (rs3025058) affects markers atherosclerosis in type 2 diabetes mellitus.
Novel Biomarkers to Improve the Prediction of Cardiovascular Event Risk in Type 2 Diabetes Mellitus.
Risk of coronary artery stenosis in Iranian type 2 diabetics: is there a role for matrix metalloproteinase-3 gene (-1612 5A/6A) polymorphism?
Scoring Model to Predict a Low Disease Activity in Elderly Rheumatoid Arthritis Patients Initially Treated with Biological Disease-modifying Antirheumatic Drugs.
Diabetes Mellitus, Type 1
The skin remodeling in type 1 diabetes and insulin resistance animal models.
Diabetes Mellitus, Type 2
Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.
Association Between Matrix Metalloproteinase-3 Activity and Glomerular Filtration Rate and Albuminuria Status in Patients With Type 2 Diabetes Mellitus.
Impact of ENPP1 and MMP3 gene polymorphisms on aortic calcification in patients with type 2 diabetes in a Korean population.
Matrix metalloproteinase-3 gene polymorphism (rs3025058) affects markers atherosclerosis in type 2 diabetes mellitus.
Novel Biomarkers to Improve the Prediction of Cardiovascular Event Risk in Type 2 Diabetes Mellitus.
Risk of coronary artery stenosis in Iranian type 2 diabetics: is there a role for matrix metalloproteinase-3 gene (-1612 5A/6A) polymorphism?
Diabetic Nephropathies
Association Between Matrix Metalloproteinase-3 Activity and Glomerular Filtration Rate and Albuminuria Status in Patients With Type 2 Diabetes Mellitus.
Collagenase-1 (-1607 1G/2G), Gelatinase-A (-1306 C/T), Stromelysin-1 (-1171 5A/6A) functional promoter polymorphisms in risk prediction of type 2 diabetic nephropathy.
In situ hybridization studies of matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-1 and type IV collagen in diabetic nephropathy.
Diabetic Retinopathy
Correlations of MMP-3 and MMP-9 gene polymorphisms with diabetic retinopathy.
Dry Eye Syndromes
Dexamethasone nanowafer as an effective therapy for dry eye disease.
Duodenal Ulcer
Elevated Serum Matrix Metalloproteinase-3 and -7 in H. pylori-Related Gastric Cancer Can Be Biomarkers Correlating with a Poor Survival.
Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females.
[Role of Allelic Genes of Matrix Metalloproteinases and Their Tissue Inhibitors in the Peptic Ulcer Disease Development].
Dysentery, Amebic
The parasite Entamoeba histolytica exploits the activities of human matrix metalloproteinases to invade colonic tissue.
Encephalitis
Chemokines and matrix metalloproteinases in cerebrospinal fluid of patients with central nervous system complications caused by varicella-zoster virus.
Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis.
Encephalomyelitis
MMP-12, MMP-3, and TIMP-1 are markedly upregulated in chronic demyelinating theiler murine encephalomyelitis.
Endoleak
Plasma Matrix Metalloproteinase 9 Levels May Predict Endoleaks After Endovascular Aortic Aneurysm Repair.
Endometrial Neoplasms
Matrix metalloproteinase-7 (MMP-7) polymorphism is a risk factor for endometrial cancer susceptibility.
No Association between Matrix Metalloproteinase (MMP)-1, MMP-3, and MMP-7 SNPs and Endometrial Cancer Risk.
Endometriosis
Curcumin as anti-endometriotic agent: implication of MMP-3 and intrinsic apoptotic pathway.
Differential regulation of matrix metalloproteinase-3 gene expression in endometriotic lesions compared with endometrium.
Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget.
Effect of matrix metalloproteinase promoter polymorphisms on endometriosis and adenomyosis risk: evidence from a meta-analysis.
Eutopic endometrium and peritoneal, ovarian and bowel endometriotic tissues express a different profile of matrix metalloproteinases-2, -3 and -11, and of tissue inhibitor metalloproteinases-1 and -2.
Expression of angiogenic factors in endometriosis: relationship to fibrinolytic and metalloproteinase systems.
Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis.
Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis.
Matrix Metalloproteinase-3 mRNA: A Promising Peripheral Blood Marker for Diagnosis of Endometriosis.
Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway.
mRNA analysis of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis using a real-time quantitative RT-PCR assay.
Performance of peripheral (serum and molecular) blood markers for diagnosis of endometriosis.
Regulation of matrix metalloproteinases and their inhibitors in uterine endometrial cells of patients with and without endometriosis.
Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice.
[Expression of matrix metalloproteinase and tissue inhibitor of metalloproteinase in adenomyosis]
[Expression of MMP-3 and TIMP-1 in the endometriosis and the influence of danazol]
[Single nucleotide polymorphism in the matrix metalloproteinases promoter is associated with susceptibility to endometriosis and adenomyosis]
Endometritis
Increasing of matrix metalloproteinase 3 in bovine endometritis.
Ependymoma
Medulloblastoma displays distinct regional matrix metalloprotease expression.
Epidermolysis Bullosa Dystrophica
Exclusion of stromelysin-1, stromelysin-2, interstitial collagenase and fibronectin genes as the mutant loci in a family with recessive epidermolysis bullosa dystrophica and a form of cerebellar ataxia.
Expression of collagenase and stromelysin in skin fibroblasts from recessive dystrophic epidermolysis bullosa.
Gene expression of collagenase and stromelysin in skin fibroblasts derived from dystrophic epidermolysis bullosa.
Increased gene expression of matrix metalloproteinase-3 (stromelysin) in skin fibroblasts from patients with severe recessive dystrophic epidermolysis bullosa.
Skin expression of metalloproteinases and tissue inhibitor of metalloproteinases in sibling patients with recessive dystrophic epidermolysis and intrafamilial phenotypic variation.
Epilepsy
Evaluation of serum matrix metalloproteinase-3 as a biomarker for diagnosis of epilepsy.
Matrix metalloproteinase-3 in myasthenia gravis compared to other neurological disorders and healthy controls.
Matrix metalloproteinases during and outside of migraine attacks without aura.
Epiretinal Membrane
Predominance of MMP-1 and MMP-2 in epiretinal and subretinal membranes of proliferative vitreoretinopathy.
Erythema
Detection of active matrix metalloproteinase-3 in serum and fibroblast-like synoviocytes of collagen-induced arthritis mice.
Esophageal Squamous Cell Carcinoma
Differential expression of MMP and uPA systems and prognostic relevance of their expression in esophageal squamous cell carcinoma.
NFAT1 promotes cell motility through MMP-3 in esophageal squamous cell carcinoma.
The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinoma.
Exanthema
Increased levels of matrix metalloproteinase-3 in sera from patients with active lupus nephritis.
Fibroadenoma
Immunolocalization of matrix metallo-proteinases and their tissue inhibitor in human mammary pathology.
Fibromyalgia
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
Fibrosarcoma
Autotaxin promotes the expression of matrix metalloproteinase-3 via activation of the MAPK cascade in human fibrosarcoma HT-1080 cells.
Okadaic acid-elicited transcriptional activation of collagenase gene expression in HT-1080 fibrosarcoma cells is mediated by JunB.
Repression of stromelysin metalloprotease expression in rat fibrosarcoma cells by dimethylsulfoxide.
Steps involved in activation of the pro-matrix metalloproteinase 9 (progelatinase B)-tissue inhibitor of metalloproteinases-1 complex by 4-aminophenylmercuric acetate and proteinases.
Tumorigenic and metastatic properties of two ras-oncogene transfected rat fibrosarcoma cell lines defective in c-jun.
Gastritis
Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori-positive and Helicobacter pylori-negative gastritis.
Elevated Serum Matrix Metalloproteinase-3 and -7 in H. pylori-Related Gastric Cancer Can Be Biomarkers Correlating with a Poor Survival.
Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females.
Gastrointestinal Diseases
Elevated Serum Matrix Metalloproteinase-3 and -7 in H. pylori-Related Gastric Cancer Can Be Biomarkers Correlating with a Poor Survival.
gelatinase b deficiency
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response.
Mmp-9 deficiency enhances collagenase-induced intracerebral hemorrhage and brain injury in mutant mice.
Gingival Overgrowth
Immunolocalization of collagenase (MMP-1) and stromelysin (MMP-3) in the gingival tissues of organ transplant patients medicated with cyclosporin.
Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth.
Gingivitis
Gingival crevicular stromelysin, collagenase and tissue inhibitor of metalloproteinases levels in healthy and diseased sites.
Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva.
[Expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model]
Glaucoma
Alteration of MCP-1 and MMP-9 in aqueous humor is associated with secondary glaucoma in Fuchs uveitis syndrome.
Effects of matrix metalloproteinase-3 gene transfer by electroporation in glaucoma filter surgery.
Matrix metalloproteinase and cytokine expression in Tenon fibroblasts during scar formation after glaucoma filtration or implant surgery in rats.
Sustained release of matrix metalloproteinase-3 to trabecular meshwork cells using biodegradable PLGA microparticles.
Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma.
Glaucoma, Open-Angle
Early changes in matrix metalloproteinases and inhibitors after in vitro laser treatment to the trabecular meshwork.
IL-1 and TNF induction of matrix metalloproteinase-3 by c-Jun N-terminal kinase in trabecular meshwork.
Glioblastoma
Heterogeneous regional expression patterns of matrix metalloproteinases in human malignant gliomas.
Interleukin-1?-induced matrix metalloproteinase-3 via ERK1/2 pathway to promote mesenchymal stem cell migration.
Glioma
A novel NF-?B/MMP-3 signal pathway involves in the aggressivity of glioma promoted by Bmi-1.
A role of matrix metalloproteinases produced by glioma-cells.
Effects of dexmedetomidine on glioma cells in the presence or absence of cisplatin.
Expressions of matrilysin and stromelysin in human glioma cells.
Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression.
Interferon-gamma regulation of TNFalpha-induced matrix metalloproteinase 3 expression and migration of human glioma T98G cells.
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas.
Medulloblastoma displays distinct regional matrix metalloprotease expression.
MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3.
Proteolysis of the matricellular protein hevin by matrix metalloproteinase-3 produces a SPARC-like fragment (SLF) associated with neovasculature in a murine glioma model.
Suppression of CLC-3 chloride channel reduces the aggressiveness of glioma through inhibiting nuclear factor-?B pathway.
Suppressor of Fused Inhibits Skin Wound Healing.
Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression.
[Increased expression of gelatinases A and B, matrilysin and TIMP-1 genes in human malignant gliomas ]
Glomerulonephritis
Changes in serum concentrations of matrix metalloproteinases, tissue inhibitors of metalloproteinases and type IV collagen in patients with various types of glomerulonephritis.
Stromelysin-1 expression is activated in vivo by Ets-1 through palindromic head-to-head Ets binding sites present in the promoter.
Glomerulonephritis, IGA
Changes in serum concentrations of matrix metalloproteinases, tissue inhibitors of metalloproteinases and type IV collagen in patients with various types of glomerulonephritis.
Localization of glycated proteins in the glomeruli of patients with diabetic nephropathy.
Gout
Detection of stromelysin in synovial fluid and serum from patients with rheumatoid arthritis and osteoarthritis.
Elevated plasma stromelysin levels in arthritis.
Granuloma
Expression kinetics of metalloproteinases and their tissue inhibitors in experimental murine pulmonary tuberculosis.
Interstitial collagenase (MMP-1), gelatinase (MMP-2) and stromelysin (MMP-3) released by human fibroblasts cultured on acellular sarcoid granulomas (sarcoid matrix complex, SMC).
Guillain-Barre Syndrome
Matrix metalloproteinase-9 is increased and correlates with severity in Guillain-Barré syndrome.
Hearing Loss
Elevated matrix metalloproteinase-3 level may affect hearing function in patients with rheumatoid arthritis.
Hearing Loss, Sensorineural
Elevated matrix metalloproteinase-3 level may affect hearing function in patients with rheumatoid arthritis.
Heart Diseases
Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development.
The matrix metalloproteinase-3 (MMP-3) 5A/6A promoter polymorphism is not associated with ischaemic heart disease: analysis employing a family based approach.
Heart Failure
Circulating matrix metalloproteinase-2 but not matrix metalloproteinase-3, matrix metalloproteinase-9, or tissue inhibitor of metalloproteinase-1 predicts outcome in patients with congestive heart failure.
Circulating Stromelysin-1 (MMP-3): a novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarction.
Comparison of levels of matrix metalloproteinase-2 and -3 in patients with ischemic cardiomyopathy versus nonischemic cardiomyopathy.
Differential expression of MMPs and TIMPs in moderate and severe heart failure in a transgenic model.
Metalloproteinase expression is altered in cardiac and skeletal muscle in cancer cachexia.
Myocardial matrix metalloproteinase-3 and matrix metalloproteinase inhibitor-1 expression in congestive heart failure.
Progression of matrixin and cardiokine expression patterns in an ovine model of heart failure and recovery.
Reverse remodeling is associated with changes in extracellular matrix proteases and tissue inhibitors after mesenchymal stem cell (MSC) treatment of pressure overload hypertrophy.
Structural studies of the MMP-3 interaction with triple-helical collagen introduce new roles for the enzyme in tissue remodelling.
[Assessment of the role of matrix metalloproteinase-3 gene polymorphism in the development of chronic heart failure].
[Matrix metalloproteinases and their inhibitors in lung cancer with malignant pleural effusion]
Heart Failure, Systolic
Circulating matrix metalloproteinase-3 and metalloproteinase-9 and tissue Doppler measures of diastolic dysfunction to risk stratify patients with systolic heart failure.
Hemochromatosis
Evidence for altered hepatic matrix degradation in genetic haemochromatosis.
Hemophilia A
[Matrix metalloproteinase (MMP)-3 is not effective for evaluating hemophilic arthropathy].
Hemorrhagic Stroke
Apolipoprotein A-I and Paraoxonase-1 Are Potential Blood Biomarkers for Ischemic Stroke Diagnosis.
Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial infarction, ischemic stroke, and hemorrhagic stroke.
Hepatitis
Clinical significance of serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in chronic liver disease.
Matrix metalloproteinases and their inhibitors in acute viral hepatitis.
Hepatitis B
Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3.
Matrix metalloproteinase-3 genotypes influence recovery from hepatitis B virus infection.
[Comparisons of the characteristics and mechanisms of HBV replication in QSG-7701 and HepG2 cell lines]
Hepatitis B, Chronic
Matrix metalloproteinase (MMP)-3 polymorphism in patients with HBV related chronic liver disease.
Hepatitis C
The genotypes of IL-1 beta and MMP-3 are associated with the prognosis of HCV-related hepatocellular carcinoma.
Hepatitis C, Chronic
Association of genetic polymorphisms with histological grading of necroinflammation, staging of fibrosis, and liver function in mexicans with chronic hepatitis C virus infection.
Hepatitis, Chronic
Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease.
Clinical significance of serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in chronic liver disease.
Serum matrix metalloproteinase-3 (stromelysin-1) concentration in patients with chronic liver disease.
Herpes Simplex
Molecular characterization of a novel transcription factor that controls stromelysin expression.
Histiocytoma, Malignant Fibrous
Expression of the transin, c-fos, and c-jun genes in rat transplantable osteosarcomas and malignant fibrous histiocytomas.
Hydrocephalus
Elevation of matrix metalloproteinases 3 and 9 in cerebrospinal fluid and blood in patients with severe traumatic brain injury.
Hydrocephalus, Normal Pressure
Elevation of matrix metalloproteinases 3 and 9 in cerebrospinal fluid and blood in patients with severe traumatic brain injury.
Hyperalgesia
Physiologic facet capsule stretch can induce pain & upregulate matrix metalloproteinase-3 in the dorsal root ganglia when preceded by a physiological mechanical or nonpainful chemical exposure.
Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism.
Hyperglycemia
Danzhi Jiangtang capsule alleviate hyperglycemia and periodontitis via Wnt/?-catenin signaling in diabetic rat.
Hyperlipidemias
CD11c+ macrophages and levels of TNF-? and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidemia.
Combined impact of matrix metalloproteinase-3 and paraoxonase 1 55/192 gene variants on coronary artery disease in Turkish patients.
Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 as potential markers of carotid atherosclerosis in infraclinical hyperlipidemia.
Hypersensitivity
Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism.
Hypertension
Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development.
Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease.
Combined impact of matrix metalloproteinase-3 and paraoxonase 1 55/192 gene variants on coronary artery disease in Turkish patients.
Derivation and internal validation of a multi-biomarker-based cardiovascular disease risk prediction score for rheumatoid arthritis patients.
Endothelial NOS G894 T and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian population.
Genetic risk and gene-environment interaction in coronary artery spasm in Japanese men and women.
Pharmacogenetic effect of the stromelysin (MMP3) polymorphism on stroke risk in relation to antihypertensive treatment: the genetics of hypertension associated treatment study.
Polymorphisms of MMP-3 and TIMP-4 genes affect angiographic coronary plaque progression in non-diabetic and type 2 diabetic patients.
The effect of antihypertensive treatment on arterial stiffness and serum concentration of selected matrix metalloproteinases.
The Use of Serum Matrix Metalloproteinases in Cerebral Amyloid Angiopathy-Related Intracerebral Hemorrhage and Cognitive Impairment.
Hypertension, Portal
High serum matrix metalloproteinase-3 and liver stiffness in postoperative biliary atresia.
Hypertension, Pulmonary
Immunohistochemical study of endothelin-1 and matrix metalloproteinases in plexogenic pulmonary arteriopathy.
Relationship between matrix metalloproteinase-3 serum level and pulmonary artery systolic pressure in patients with rheumatoid arthritis.
Hypoalbuminemia
Increased levels of matrix metalloproteinase-3 in sera from patients with active lupus nephritis.
Hypoxia-Ischemia, Brain
MMP-9 and MMP-3 gene polymorphisms in neonatal hypoxic ischemic encephalopathy.
Infarction, Middle Cerebral Artery
Activation of matrix metalloproteinase-3 and agrin cleavage in cerebral ischemia/reperfusion.
Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice.
Infections
Borrelia burgdorferi-induced expression of matrix metalloproteinases from human chondrocytes requires mitogen-activated protein kinase and Janus kinase/signal transducer and activator of transcription signaling pathways.
Comparison of cytokine profiles induced by nonlethal and lethal doses of influenza A virus in mice.
Curcumin alleviates matrix metalloproteinase-3 and -9 activities during eradication of Helicobacter pylori infection in cultured cells and mice.
Dissociation of ras oncogene-induced gene expression and anchorage-independent growth in a series of somatic cell mutants.
Doxycycline treatment prevents alveolar destruction in VEGF-deficient mouse lung.
Effect of adenovirus-mediated overexpression of decorin on metalloproteinases, tissue inhibitors of metalloproteinases and cytokines secretion by human gingival fibroblasts.
Epithelial and bacterial metalloproteinases and their inhibitors in H. pylori infection of human gastric cells.
Expression kinetics of metalloproteinases and their tissue inhibitors in experimental murine pulmonary tuberculosis.
Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis.
General and specific host responses to bacterial infection in Peyer's patches: a role for stromelysin-1 (matrix metalloproteinase-3) during Salmonella enterica infection.
Ginkgo biloba extract may alleviate viral myocarditis by suppression of S100A4 and MMP-3.
Helicobacter pylori CagA protein induces factors involved in the epithelial to mesenchymal transition (EMT) in infected gastric epithelial cells in an EPIYA- phosphorylation-dependent manner.
Heparanase-Regulated Syndecan-1 Shedding Facilitates Herpes Simplex Virus 1 Egress.
Host metalloproteinases in Lyme arthritis.
Human cytomegalovirus induces MMP-1 and MMP-3 expression in aortic smooth muscle cells.
Increased production of matrix metalloproteinases 1 and 3 by smooth muscle cells upon infection with Chlamydia pneumoniae.
Interleukin 1beta induces gastric epithelial cell matrix metalloproteinase secretion and activation during Helicobacter pylori infection.
Matrix metalloproteinase 3 in parturition, premature rupture of the membranes, and microbial invasion of the amniotic cavity.
Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection.
Matrix metalloproteinase-3 genotypes influence recovery from hepatitis B virus infection.
Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females.
MMP-12, MMP-3, and TIMP-1 are markedly upregulated in chronic demyelinating theiler murine encephalomyelitis.
Modified Profile of Matrix Metalloproteinase 2 and 9 Production by Human Fallopian Tube Epithelial Cells After Infection In Vitro With Neisseria gonorrhoeae.
Neisseria gonorrhoeae Challenge Increases Matrix Metalloproteinase-8 Expression in Fallopian Tube Explants.
Neurotrophic factor levels in the serum and cerebrospinal fluid of neonates infected with human cytomegalovirus.
Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice.
Proteins involved in extracellular matrix dynamics are associated with RSV disease severity.
Transforming growth factor-beta induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase.
[Matrix metalloproteinase-3 in patients with systemic lupus erythematosus and its significance in differentiating disease activity from pulmonary infections].
Inflammatory Bowel Diseases
CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-? and MMP-3 production in patients with inflammatory bowel disease.
Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease.
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease.
Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intestine.
Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease.
Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease.
Matrix Metalloproteinase 3 Predicts Therapeutic Response in Inflammatory Bowel Disease Patients Treated With Infliximab.
Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease.
Insulin Resistance
Impact of disease activity on impaired glucose metabolism in patients with rheumatoid arthritis.
The skin remodeling in type 1 diabetes and insulin resistance animal models.
Intervertebral Disc Degeneration
17?-Estradiol inhibits intervertebral disc degeneration by down-regulating MMP-3 and MMP-13 and up-regulating type II collagen in a rat model.
Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-? stimulation.
Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats.
APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix.
Assessment of the Matrix Degenerative Effects of MMP-3, ADAMTS-4 and HTRA1 injected into a bovine Intervertebral Disc Organ Culture Model.
Correlation of Matrix Metalloproteinase-3 Expression with Patient Age, Magnetic Resonance Imaging and Histopathological Grade in Lumbar Disc Degeneration.
Effects of MMP-1 and MMP-3 gene polymorphisms on gene expression and protein level in lumbar disc herniation.
Genetic Dimension of Intervertebral Disc Degeneration: Polymorphism of Matrix Metalloproteinase 1 and 3 in the North Iranian Population.
Genetic Influence in Disc Degeneration - Systematic Review of Literature.
Genetic risk factors for lumbar disc disease.
Immunohistochemical study of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 human intervertebral discs.
Interleukin-1? exacerbates the catabolic effects of human nucleus pulposus cells through activation of the Nuclear Factor kappa B signaling pathway under hypoxic conditions.
Kinetics of tissue and serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 in intervertebral disc degeneration and disc herniation.
Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration.
Matrix metalloproteinase-3 and vitamin d receptor genetic polymorphisms, and their interactions with occupational exposure in lumbar disc degeneration.
Matrix metalloproteinase-3 production by human degenerated intervertebral disc.
Matrix Metalloproteinase-3, Vitamin D Receptor Gene Polymorphisms, and Occupational Risk Factors in Lumbar Disc Degeneration.
Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis.
Syndecan 4 signaling and intervertebral disc degeneration.
The genetics of intervertebral disc degeneration. Associated genes.
Tumor necrosis factor-?- and interleukin-1?-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-?B axis: implications in inflammatory disc disease.
TWEAK and TSLP in disc degeneration and spontaneous hernia resorption.
Vitamin D Receptor Gene, Matrix Metalloproteinase 3 Polymorphisms and the Risk of Intervertebral Disc Degeneration Susceptibility: Meta-Analysis.
[Effects of electroacupuncture at Jiaji (EX-B 2) on extracellular matrix MMP-1, MMP-3 and TIMP-1 levels in the degenerated cervical intervertebral disc in rats]
[Synergistic interaction between MMP-3, VDR gene polymorphisms and occupational risk factors on lumbar disc degeneration]
Intervertebral Disc Displacement
Chemokine profile of disc degeneration with acute or chronic pain.
Correlation of Matrix Metalloproteinase-3 Expression with Patient Age, Magnetic Resonance Imaging and Histopathological Grade in Lumbar Disc Degeneration.
Correlation of matrix metalloproteinases-1 and -3 with patient age and grade of lumbar disc herniation.
Effects of MMP-1 and MMP-3 gene polymorphisms on gene expression and protein level in lumbar disc herniation.
Experimental studies on the effects of recombinant human matrix metalloproteinases on herniated disc tissues--how to facilitate the natural resorption process of herniated discs.
Herniated and spondylotic intervertebral discs of the human cervical spine: histological and immunohistological findings in 500 en bloc surgical samples. Laboratory investigation.
Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation.
Influence of macrophage infiltration of herniated disc tissue on the production of matrix metalloproteinases leading to disc resorption.
Interactions between the MMP-3 gene rs591058 polymorphism and occupational risk factors contribute to the increased risk for lumbar disk herniation: A case-control study.
Kinetics of tissue and serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 in intervertebral disc degeneration and disc herniation.
The increased expression of matrix metalloproteinases associated with elastin degradation and fibrosis of the ligamentum flavum in patients with lumbar spinal stenosis.
The involvement of matrix metalloproteinases and inflammation in lumbar disc herniation.
Transcript levels of major MMPs and ADAMTS-4 in relation to the clinicopathological profile of patients with lumbar disc herniation.
[Determination on contents of matrix metalloproteinase 3 and interleukin 1 in tissues of lumbar disc herniation and their roles in pathogenesis]
Intracranial Hemorrhages
Role of tissue-type plasminogen activator in ischemic stroke.
Ischemic Stroke
Apolipoprotein A-I and Paraoxonase-1 Are Potential Blood Biomarkers for Ischemic Stroke Diagnosis.
Association Between Matrix Metalloproteinase Family Gene Polymorphisms and Ischemic Stroke: a Meta-analysis.
Association of Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Variants with Ischemic Stroke and Its Subtype.
Association of matrix metalloproteinase-3 gene 5A/6A polymorphism with the recurrence of ischemic stroke: A prospective observational study.
Association of the matrix metalloproteinase-3 polymorphisms rs679620 and rs3025058 with ischemic stroke risk: a meta-analysis.
Impact of 5A/6A polymorphism of matrix metalloproteinase-3 on recurrent atherosclerotic ischemic stroke in Chinese.
Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial infarction, ischemic stroke, and hemorrhagic stroke.
Matrix metalloproteinase-3 gene polymorphisms are associated with ischemic stroke.
Novel situations of endothelial injury in stroke--mechanisms of stroke and strategy of drug development: Intracranial bleeding associated with the treatment of ischemic stroke: thrombolytic treatment of ischemia-affected endothelial cells with tissue-type plasminogen activator.
Profiles of matrix metalloproteinases, their inhibitors, and laminin in stroke patients: influence of different therapies.
Role of tissue-type plasminogen activator in ischemic stroke.
Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice.
The rtPA increases MMP-9 activity in serum during ischaemic stroke.
[Association of matrix metalloproteinase-3 gene polymorphisms with subtypes of ischemic stroke].
[Association of matrix metalloproteinase-3 serum level and the promoter 5A/6A polymorphism of the MMP-3 gene with atherosclerotic cerebral infarction]
[Evaluation for antithrombotic agents by a thrombotic model in animals].
Joint Diseases
Beta 2-microglobulin induces stromelysin production by human synovial fibroblasts.
Biomarkers of joint tissue metabolism in canine osteoarthritic and arthritic joint disorders.
Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers.
Effect of selected antirheumatic drugs on the metabolism of cartilage and synovial tissue in experimental arthropathy.
Imbalanced MMP-3 and MMP-12 serum levels in systemic lupus erythematosus patients with Jaccoud's arthropathy and a distinctive MRI pattern.
Increased serum stromelysin-1 levels in systemic lupus erythematosus: lack of correlation with disease activity.
Infliximab Induced a Dissociated Response of Severe Periodontal Biomarkers in Rheumatoid Arthritis Patients.
Molecular characteristics of equine stromelysin and the tissue inhibitor of metalloproteinase 1.
Serum matrix metalloproteinase-3 as a noninvasive biomarker of histological synovitis for diagnosis of rheumatoid arthritis.
Simvastatin reduces MMP-3 level in interleukin 1beta stimulated human chondrocyte culture.
Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.
Superantigen-induced stromelysin production from rheumatoid synovial cells.
Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not.
The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases.
Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats.
[Matrix metalloproteinase (MMP)-3 is not effective for evaluating hemophilic arthropathy].
Keloid
Epigenetically altered wound healing in keloid fibroblasts.
Keratoconjunctivitis
Overexpression of Matrix Metalloproteinase-1 (MMP-1) and MMP-3 in Superior Limbic Keratoconjunctivitis.
Keratoconus
Is the corneal degradation in keratoconus caused by matrix-metalloproteinases?
Keratosis, Actinic
Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis.
Leg Ulcer
Induction of MMP-1, MMP-3 and TIMP-1 in normal dermal fibroblasts by chronic venous leg ulcer wound fluid*.
Legg-Calve-Perthes Disease
Increased levels of proteoglycan fragments and stromelysin in hip joint fluid in Legg-Calvé-Perthes disease.
Leiomyoma
Differential expression of matrix metalloproteinases and their tissue inhibitors in leiomyomata: a mechanism for gonadotrophin releasing hormone agonist-induced tumour regression.
Increased expression of stromelysin 3 mRNA in leiomyomas (uterine fibroids) compared with myometrium.
Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells.
Leukemia
Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta.
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
Inflammatory responses induced by interleukin-17 family members in human colonic subepithelial myofibroblasts.
MMP-3 expression and release by rheumatoid arthritis fibroblast-like synoviocytes induced with a bacterial ligand of integrin alpha5beta1.
[Comparisons of the characteristics and mechanisms of HBV replication in QSG-7701 and HepG2 cell lines]
Leukoplakia
Galectin-9 as an important marker in the differential diagnosis between oral squamous cell carcinoma, oral leukoplakia and oral lichen planus.
Lichen Planus
Expression of matrix metalloproteinases (MMP-2, MMP-3, and MMP-9) and fibronectin in lichen planus.
Galectin-9 as an important marker in the differential diagnosis between oral squamous cell carcinoma, oral leukoplakia and oral lichen planus.
Lichen Planus, Oral
Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma
Serum and Saliva MMP-3 in Patients with OLP and Oral SCC.
Serum level of matrix metalloproteinase-3 in patients with oral lichen planus.
Lipoma
Lipoma arborescens co-existing with psoriatic arthritis releases tumour necrosis factor alpha and matrix metalloproteinase 3.
Liver Cirrhosis
Adenoviral delivery of dominant-negative transforming growth factor beta type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats.
Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease.
Association of genetic polymorphisms with histological grading of necroinflammation, staging of fibrosis, and liver function in mexicans with chronic hepatitis C virus infection.
Clinical significance of serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in chronic liver disease.
Collagenases and liver fibrosis.
Immunological investigation of the hepatic tissue from infants with biliary atresia.
Matrix metalloproteinase (MMP)-3 polymorphism in patients with HBV related chronic liver disease.
No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease.
Serum matrix metalloproteinase-3 (stromelysin-1) concentration in patients with chronic liver disease.
Liver Cirrhosis, Biliary
Common variants of the matrix metalloproteinase-3 (stromelysin) gene promoter in primary biliary cirrhosis.
Liver Diseases
Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease.
Serum matrix metalloproteinase-3 (stromelysin-1) concentration in patients with chronic liver disease.
Liver Neoplasms
Macrovascular Endothelial Cells Enhance the Motility of Liver Cancer Cells by Up-regulation of MMP-3, Activation of Integrin/FAK Signaling Pathway and Induction of Non-classical Epithelial-mesenchymal Transition.
Lung Diseases
Amelioration of rheumatoid arthritis in a breast cancer patient treated with palbociclib: a case report.
Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury.
Lung Injury
Lack of matrix metalloproteinase 3 in mouse models of lung injury ameliorates the pulmonary inflammatory response in female but not in male mice.
Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury.
Role of stromelysin 1 and gelatinase B in experimental acute lung injury.
Lung Neoplasms
Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism.
Carcinogenesis-related changes in iron metabolism in chronic obstructive pulmonary disease subjects with lung cancer.
Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma.
Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance.
Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer.
Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer.
Matrix metalloproteinase 3 polymorphisms as a potential marker of enhanced susceptibility to lung cancer in chronic obstructive pulmonary disease subjects.
Pleural fluid analysis of lung cancer vs benign inflammatory disease patients.
The importance of matrix metalloproteinase-3 in respiratory disorders.
The VEGFR2, COX-2 and MMP-2 polymorphisms are associated with clinical outcome of patients with inoperable non-small cell lung cancer.
Thromboxane A2 receptor-mediated release of matrix metalloproteinase-1 (MMP-1) induces expression of monocyte chemoattractant protein-1 (MCP-1) by activation of protease-activated receptor 2 (PAR2) in A549 human lung adenocarcinoma cells.
[Correlation of matrix metalloproteinase-3 polymorphism to genetic susceptibility and lymph node metastasis of non-small cell lung cancer]
Lupus Erythematosus, Systemic
Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis.
Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers.
Clinical significance of matrix metalloproteinase-3 in systemic lupus erythematosus patients: a potential biomarker for disease activity and damage.
Elevated plasma stromelysin levels in arthritis.
Elevated serum levels of MMP-2, MMP-3, and MMP-13 in Chinese patients with systemic lupus erythematosus.
Genetic contribution to carotid vascular disease in patients with systemic lupus erythematosus.
Imbalanced MMP-3 and MMP-12 serum levels in systemic lupus erythematosus patients with Jaccoud's arthropathy and a distinctive MRI pattern.
Increased levels of matrix metalloproteinase-3 in sera from patients with active lupus nephritis.
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
Increased serum stromelysin-1 levels in systemic lupus erythematosus: lack of correlation with disease activity.
Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications.
The association of serum matrix metalloproteinases and their tissue inhibitor levels with scleroderma disease severity.
[Matrix metalloproteinase-3 in patients with systemic lupus erythematosus and its significance in differentiating disease activity from pulmonary infections].
[Stromelysin-1 (MMP-3) level in the sera from patients with rheumatoid arthritis and other connective tissue diseases--clinical significances in early onset rheumatoid arthritis]
Lupus Nephritis
Changes in serum concentrations of matrix metalloproteinases, tissue inhibitors of metalloproteinases and type IV collagen in patients with various types of glomerulonephritis.
Glomerular expression of matrix metalloproteinases in systemic lupus erythematosus in association with activity index and renal function.
Increased levels of matrix metalloproteinase-3 in sera from patients with active lupus nephritis.
Lyme Disease
Borrelia burgdorferi-induced expression of matrix metalloproteinases from human chondrocytes requires mitogen-activated protein kinase and Janus kinase/signal transducer and activator of transcription signaling pathways.
Host metalloproteinases in Lyme arthritis.
[Usefulness of examinations of serum levels of matrix metalloproteinases 1, MMP-3, MMP-9, tissue inhibitor of metalloproteinases 1, hyaluronic acid and antibodies against cyclic citrullinated peptide in Lyme arthritis, rheumatoid arthritis and patients with arthritic complaints].
Lyme Neuroborreliosis
Upregulation of matrix metalloproteinase-9 in the cerebrospinal fluid of patients with acute Lyme neuroborreliosis.
Lymphangioleiomyomatosis
Immunohistochemical study of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pulmonary lymphangioleiomyomatosis (LAM).
Lymphatic Metastasis
Expression of matrix metalloproteinase-3 in stage I and II squamous cell carcinoma of the oral cavity.
Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis.
Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material.
The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinoma.
[Correlation of matrix metalloproteinase-3 polymorphism to genetic susceptibility and lymph node metastasis of non-small cell lung cancer]
[Expression and correlation with metastasis of E-cadherin, CD44H, matrix metalloproteinase-3, nm23H1 and VEGF in nasopharyngeal carcinoma]
Lymphoma
Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas.
Stromelysin-1 (MMP-3) is inducible in T lymphoma cells and accelerates the growth of lymphoid tumors in vivo.
Lymphoma, B-Cell
Matrix Metalloproteinase-3 Producing Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Associated With Rheumatoid Arthritis.
Resveratrol inhibits oxygen-glucose deprivation-induced MMP-3 expression and cell apoptosis in primary cortical cells via the NF-?B pathway.
Lymphoma, Large B-Cell, Diffuse
Matrix Metalloproteinase-3 Producing Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Associated With Rheumatoid Arthritis.
Macrophage Activation Syndrome
Distinct subsets of patients with systemic juvenile idiopathic arthritis based on their cytokine profiles.
Macular Degeneration
Age-related macular degeneration: a perspective on genetic studies.
Does matrix metalloproteinase-3 polymorphism play a role in age-related macular degeneration in patients with myocardial infarction?
The Role of Matrix Metalloproteinases Polymorphisms in Age-Related Macular Degeneration.
Malaria
Increased expression of kidney injury molecule-1 and matrix metalloproteinase-3 in severe Plasmodium falciparum malaria with acute kidney injury.
Malaria, Falciparum
Increased expression of kidney injury molecule-1 and matrix metalloproteinase-3 in severe Plasmodium falciparum malaria with acute kidney injury.
Marfan Syndrome
Immunohistochemistry of matrix metalloproteinases and their inhibitors in thoracic aortic aneurysms and aortic valves of patients with Marfan's syndrome.
Mastocytoma
Mast cell proteinases activate precursor forms of collagenase and stromelysin, but not of gelatinases A and B.
Medulloblastoma
Medulloblastoma displays distinct regional matrix metalloprotease expression.
Melanoma
Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts.
Circulating levels of vascular endothelial growth factor (VEGF), matrix metalloproteinase-3 (MMP-3), and BCL-2 in malignant melanoma.
High expression levels of collagenase-1 and stromelysin-1 correlate with shorter disease-free survival in human metastatic melanoma.
Immunolocalisation studies of matrix metalloproteinases-1, -2 and -3 in human melanoma.
Induction of Matrix Metalloproteinase-3 (MMP-3) Expression in the Microglia by Lipopolysaccharide (LPS) via Upregulation of Glycoprotein Nonmetastatic Melanoma B (GPNMB) Expression.
Locally generated VGVAPG and VAPG elastin-derived peptides amplify melanoma invasion via the galectin-3 receptor.
Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression.
MMP-9 is predominantly expressed in epithelioid and not spindle cell uveal melanoma.
NFAT1 directly regulates IL-8 and MMP-3 to promote melanoma tumor growth and metastasis.
Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in patients with malignant melanoma.
SOX2 contributes to melanoma cell invasion.
Targeting TGF-?-Mediated SMAD Signaling Pathway via Novel Recombinant Cytotoxin II: A Potent Protein from Naja naja oxiana Venom in Melanoma.
Update on biomarkers in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting.
Meningioma
The Effect of Matrix Metalloproteinase-3 on the Prognosis and Biological Behaviour of Meningiomas.
Meningitis
A case of idiopathic hypertrophic cranial pachymeningitis presenting high values of matrix metalloproteinase.
Chemokines and matrix metalloproteinases in cerebrospinal fluid of patients with central nervous system complications caused by varicella-zoster virus.
Meningitis, Bacterial
Differential expression of matrix metalloproteinases in bacterial meningitis.
Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae.
Meningitis, Viral
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in viral meningitis: upregulation of MMP-9 and TIMP-1 in cerebrospinal fluid.
Mesothelioma
Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma.
Mesothelioma, Malignant
Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma.
Regulation of matrix metalloprotease activity in malignant mesothelioma cell lines by growth factors.
Metrorrhagia
Endometrial histology, microvascular density and caliber, and matrix metalloproteinase-3 in users of the Nestorone-releasing contraceptive implant with and without endometrial breakthrough bleeding.
Migraine Disorders
Combined effects of ACE and MMP-3 polymorphisms on migraine development.
Low fetuin-A level in migraine: a case-control study.
Matrix metalloproteinases during and outside of migraine attacks without aura.
Migraine without Aura
Matrix metalloproteinases during and outside of migraine attacks without aura.
Mitral Valve Insufficiency
Promoter polymorphism of the matrix metalloproteinase 3 gene is associated with regurgitation and left ventricular remodelling in mitral valve prolapse patients.
Mitral Valve Prolapse
Promoter polymorphism of the matrix metalloproteinase 3 gene is associated with regurgitation and left ventricular remodelling in mitral valve prolapse patients.
Mixed Connective Tissue Disease
[Stromelysin-1 (MMP-3) level in the sera from patients with rheumatoid arthritis and other connective tissue diseases--clinical significances in early onset rheumatoid arthritis]
Mouth Neoplasms
Association of -1171 promoter polymorphism of matrix metalloproteinase-3 with increased risk for oral cancer.
Biomarkers in saliva for the detection of oral squamous cell carcinoma and their potential use for early diagnosis: a systematic review.
Plasma levels of the tissue inhibitor matrix metalloproteinase-3 as a potential biomarker in oral cancer progression.
Moyamoya Disease
Association between matrix metalloproteinase-3 gene polymorphism and moyamoya disease.
Association of a Functional Polymorphism in the MMP-3 Gene with Moyamoya Disease in the Chinese Han Population.
Impacts and interactions of PDGFRB, MMP-3, TIMP-2, and RNF213 polymorphisms on the risk of Moyamoya disease in Han Chinese human subjects.
Mucocutaneous Lymph Node Syndrome
Arthritis associated with Kawasaki disease: MRI findings and serum matrix metalloproteinase-3 profiles.
Association of the matrix metalloproteinase-3 (-439C/G) promoter polymorphism with Kawasaki disease in Korean children.
Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease.
Tissue inhibitor of metalloproteinases-1 and matrix metalloproteinase-3 in Japanese healthy children and in Kawasaki disease and their clinical usefulness in juvenile rheumatoid arthritis.
Multiple Sclerosis
Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia.
Differences in Susceptibility of MBP Charge Isomers to Digestion by Stromelysin-1 (MMP-3) and Release of an Immunodominant Epitope.
Matrix metalloproteinase-3 in myasthenia gravis compared to other neurological disorders and healthy controls.
Matrix metalloproteinase-3 in the central nervous system: a look on the bright side.
Serum levels of matrix metalloproteinases: implications in clinical neurology.
Multiple Sclerosis, Relapsing-Remitting
Serum matrix metalloproteinase-3 levels correlate with disease activity in relapsing-remitting multiple sclerosis.
The Role of Matrix Metalloproteinase 3 and 9 in the Pathogenesis of Acute Neuroinflammation. Implications for Disease Modifying Therapy.
Muscle Weakness
Serum matrix metalloproteinase-3 levels are elevated in myasthenia gravis.
Muscular Dystrophies
Metalloproteinase expression is altered in cardiac and skeletal muscle in cancer cachexia.
Myasthenia Gravis
Matrix metalloproteinase-3 in myasthenia gravis compared to other neurological disorders and healthy controls.
Serum matrix metalloproteinase-3 levels are elevated in myasthenia gravis.
Myocardial Infarction
An association analysis between genetic polymorphisms of matrix metalloproteinase-3 and methylenetetrahydrofolate reductase and myocardial infarction in Japanese.
Cell-based gene therapy modifies matrix remodeling after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3-deficient mice.
Circulating matrix metalloproteinase 3 due to myocardial ischemia.
Circulating Stromelysin-1 (MMP-3): a novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarction.
Does matrix metalloproteinase-3 polymorphism play a role in age-related macular degeneration in patients with myocardial infarction?
Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study.
Influences of matrix metalloproteinase-3 gene variation on extent of coronary atherosclerosis and risk of myocardial infarction.
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure.
Lower serum concentration of matrix metalloproteinase-3 in the acute stage of myocardial infarction.
Matrix Metalloproteinase 3 Gene Polymorphism and Its Level Predict Morbidity After Acute Myocardial Infarction.
Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial infarction, ischemic stroke, and hemorrhagic stroke.
Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease.
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.
Prognostic value of biological markers in myocardial infarction patients.
Serum matrix metalloproteinase-3 concentration is influenced by MMP-3 -1612 5A/6A promoter genotype and associated with myocardial infarction.
Stromelysin promoter 5A/6A polymorphism is associated with acute myocardial infarction.
Stromelysin-1 promoter 5A/6A polymorphism is an independent genetic prognostic risk factor and interacts with smoking cessation after index premature myocardial infarction.
Synergistic effect of stromelysin-1 (matrix metallo-proteinase-3) promoter 5A/6A polymorphism with smoking on the onset of young acute myocardial infarction.
The roles of stromelysin-1 and the gelatinase B gene polymorphism in stable angina.
The stromelysin-1 5A/6A promoter polymorphism is a disease marker for the extent of coronary heart disease.
TIMP3 or VEGF transfection of aged human MSCs enhances cell therapy after myocardial infarction.
Usefulness of Plasma Matrix Metalloproteinase-3 Levels to Predict Myocardial Infarction in Men With and Without Acute Coronary Syndrome.
[Cardiovascular research in the era of genome medicine and EBM]
Myocardial Ischemia
Circulating matrix metalloproteinase 3 due to myocardial ischemia.
Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia.
Myocarditis
Ginkgo biloba extract may alleviate viral myocarditis by suppression of S100A4 and MMP-3.
Myopia
Assessment of the association of matrix metalloproteinases with myopia, refractive error and ocular biometric measures in an Australian cohort.
Correlations Between MMPs and TIMPs Levels in Aqueous Humor from High Myopia and Cataract Patients.
Human aqueous humor levels of transforming growth factor-?2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases.
MMP-2, MMP-3, TIMP-1, TIMP-2, and TIMP-3 protein levels in human aqueous humor: relationship with axial length.
Myopia and polymorphisms in genes for matrix metalloproteinases.
Myxoma
Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas.
The expression of apoptotic proteins and matrix metalloproteinases in odontogenic myxomas.
Nasal Polyps
Involvement of the extracellular matrix proteins periostin and tenascin C in nasal polyp remodeling by regulating the expression of MMPs.
Nasopharyngeal Carcinoma
Combination of serum matrix metalloproteinase-3 activity and EBV antibodies improves the diagnostic performance of nasopharyngeal carcinoma.
Regulation of matrix metalloproteinase-1 by Epstein-Barr virus proteins.
[Clinical significance of quantitative analysis of serum VEGF, CD44s, and MMP-3 protein in nasopharyngeal carcinoma]
[Expression and correlation with metastasis of E-cadherin, CD44H, matrix metalloproteinase-3, nm23H1 and VEGF in nasopharyngeal carcinoma]
[Expressions and correlation with radiotherapy's effect of five kinds of genes in nasopharyngeal carcinoma]
[Study of the expression of nuclear factor-kappa B, matrix metalloproteinase-3, -9 on nasopharygeal carcinoma and their clinical significance].
Neoplasm Metastasis
A high throughput fluorogenic substrate for stromelysin (MMP-3).
A novel NF-?B/MMP-3 signal pathway involves in the aggressivity of glioma promoted by Bmi-1.
A protective role for matrix metalloproteinase-3 in squamous cell carcinoma.
Alphavbeta6-Fyn signaling promotes oral cancer progression.
Association of -1171 promoter polymorphism of matrix metalloproteinase-3 with increased risk for oral cancer.
Association of E-cadherin, matrix metalloproteinases, and tissue inhibitors of metalloproteinases with the progression and metastasis of hepatocellular carcinoma.
Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer.
Caveolin-1 is an important factor for the metastasis and proliferation of human small cell lung cancer NCI-H446 cell.
CCAAT/Enhancer Binding Protein ?-Mediated MMP3 Upregulation Promotes Esophageal Squamous Cell Cancer Invasion In Vitro and Is Associated with Metastasis in Human Patients.
Characterization of 3 oral squamous cell carcinoma cell lines with different invasion and/or metastatic potentials.
Collagenase is expressed by rabbit VX2 tumour cells in syngeneic and xenogeneic hosts.
Concomitantly elevated serum matrix metalloproteinases 3 and 9 can predict survival of synchronous squamous cell carcinoma of the upper aero-digestive tract.
Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models.
Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene.
CXCR7 protein expression correlates with elevated mmp-3 secretion in breast cancer cells.
Detection and localization of mRNAs encoding matrix metalloproteinases and their tissue inhibitor in human breast pathology.
Differential gene expression during multistage carcinogenesis.
Effect of matrix metalloproteinase inhibitors on tumor growth and spontaneous metastasis.
Elevated expression of matrix metalloproteinase-3 in human osteosarcoma and its association with tumor metastasis.
Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells.
Expression of integrin beta 6 enhances invasive behavior in oral squamous cell carcinoma.
Expression of matrix metalloproteinase-3 in stage I and II squamous cell carcinoma of the oral cavity.
Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance.
Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression.
High expression levels of collagenase-1 and stromelysin-1 correlate with shorter disease-free survival in human metastatic melanoma.
High-throughput functional profiling of single adherent cells via hydrogel drop-screen.
Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89.
Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis.
Immunohistochemical expression of matrix metalloproteinases 1, 2, 9, and 14 in dermatofibrosarcoma protuberans and common fibrous histiocytoma (dermatofibroma).
Induction of hepatoma cells migration by phosphoglucose isomerase/autocrine motility factor through the upregulation of matrix metalloproteinase-3.
Inhibition of breast cancer growth and invasion by single-minded 2s.
Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids.
Involvement of matrix metalloproteinase-3 in CCL5/CCR5 pathway of chondrosarcomas metastasis.
Isolation, characterization, and expression of feline stromelysin-1 in naturally developing tumors in cats.
Isolation, characterization, and expression of stromelysin-1 in primary tumors of dogs.
Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material.
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.
Matrix metalloproteinases 1 and 3, tissue inhibitor of metalloproteinase-1 and the complex of metalloproteinase-1/tissue inhibitor in plasma of patients with prostate cancer.
Matrix metalloproteinases in neoplasm-induced extracellular matrix remodeling in breast carcinomas.
Minimally invasive colorectal resection is associated with significantly elevated levels of plasma matrix metalloproteinase 3 (MMP-3) during the first month after surgery which may promote the growth of residual metastases.
Monoclonal antibodies against human collagenase and stromelysin.
NFAT1 directly regulates IL-8 and MMP-3 to promote melanoma tumor growth and metastasis.
No association between the polymorphisms in matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter regions and colorectal cancer in chinese.
Notch3 promotes prostate cancer-induced bone lesion development via MMP-3.
Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis.
Overexpression of MMP-3 and uPA with Diminished PAI-1 Related to Metastasis in Ductal Breast Cancer Patients Attending a Public Hospital in Mexico City.
Overexpression of protein kinase C-alpha and -beta isozymes by stromal dendritic cells in basal and squamous cell carcinoma.
Pachymic acid modified carbon nanoparticles reduced angiogenesis via inhibition of MMP-3.
Phospholipase Cgamma1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade.
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.
Platelet-activating factor receptor activation promotes prostate cancer cell growth, invasion and metastasis via ERK1/2 pathway.
Prognostic Impact of Tissue Inhibitor of Metalloproteinase-1 in Non-Small Cell Lung Cancer: Systematic Review and Meta-Analysis.
Prostate cancer-derived MMP-3 controls intrinsic cell growth and extrinsic angiogenesis.
Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in patients with malignant melanoma.
Significance of coexpression of urokinase-type plasminogen activator, and matrix metalloproteinase 3 (stromelysin) and 9 (gelatinase B) in colorectal carcinoma.
Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor.
Spontaneous metastasis in matrix metalloproteinase 3-deficient mice.
Stromelysin in tumor progression and metastasis.
The inhibitor of kappa B kinase-epsilon regulates MMP-3 expression levels and can promote lung metastasis.
The inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells.
The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma.
The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas.
The significance of epidermal growth factor receptor and matrix metalloproteinase-3 in squamous cell carcinoma of the oral cavity.
The Stromal Overexpression of CD10 in Invasive Breast Cancer and its Association with Clincophathologic Factors.
[Clinical significance of quantitative analysis of serum VEGF, CD44s, and MMP-3 protein in nasopharyngeal carcinoma]
[Correlation of matrix metalloproteinase-3 polymorphism to genetic susceptibility and lymph node metastasis of non-small cell lung cancer]
[Detection of stromelysin mRNA expression in human hepatocellular carcinoma by in situ hybridization]
[Expression and correlation with metastasis of E-cadherin, CD44H, matrix metalloproteinase-3, nm23H1 and VEGF in nasopharyngeal carcinoma]
Neoplasms
(18)F-Fluorodeoxyglucose positron emission tomography and serum cytokines and matrix metalloproteinases in the assessment of disease activity in Takayasu's arteritis.
?2-Adrenoceptor is involved in connective tissue remodeling in regenerating muscles by decreasing the activity of MMP-9.
A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis.
A high throughput fluorogenic substrate for stromelysin (MMP-3).
A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes.
A protective role for matrix metalloproteinase-3 in squamous cell carcinoma.
A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression.
Accelerated atherosclerosis in premenopausal women with rheumatoid arthritis - 15-year follow-up.
Activation of inflammatory mediators and potential role of ah-receptor ligands in foam cell formation.
Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization.
Active leflunomide metabolite inhibits interleukin 1beta, tumour necrosis factor alpha, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures.
Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells.
ADAMTS5 Functions as an Anti-Angiogenic and Anti-Tumorigenic Protein Independent of Its Proteoglycanase Activity.
Additional MDA-MB-231 breast cancer cell matrix metalloproteinases promote invasiveness.
Advanced oxidation protein products induce inflammatory responses and invasive behaviour in fibroblast-like synoviocytes via the RAGE-NF-?B pathway.
Adverse Reaction of Dextran Sodium Sulfate-Induced Colitis in a Collagen-Induced Mouse Arthritis Model.
Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.
Alogliptin inhibits IL-1?-induced inflammatory response in fibroblast-like synoviocytes.
alpha1 and alpha2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression.
Alterations in the matrix metalloproteinase-3 promoter methylation after common chemotherapeutics: in vitro study of paclitaxel, cisplatin and methotrexate in the MCF-7 and SH-SY5Y cell lines.
Altered Gene and Protein Expressions in Torn Rotator Cuff Tendon Tissues in Diabetic Patients.
Altered matrix metalloproteinase expression associated with oncogene-mediated cellular transformation and metastasis formation.
An ex vivo ruminal ovine model to study the immediate immune response in the context of bacterial lipopolysaccharide.
Analysis of early biochemical markers and regulation by tin protoporphyrin IX in a model of spontaneous osteoarthritis.
Analysis of Gene Expression in Experimental Pressure Ulcers in the Rat with Special Reference to Inflammatory Cytokines.
Analysis of the cell infiltrate and expression of proinflammatory cytokines and matrix metalloproteinases in arthroscopic synovial biopsies: comparison with synovial samples from patients with end stage, destructive rheumatoid arthritis.
Anesthetic technique and the cytokine and matrix metalloproteinase response to primary breast cancer surgery.
Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex.
Anti-photoaging potential of Botulinum Toxin Type A in UVB-induced premature senescence of human dermal fibroblasts in vitro through decreasing senescence-related proteins.
Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Ameliorates Cartilage Degradation in a Rat Model of Chronic Sports Arthritic Injury.
Antitumor efficacy of hypothemycin, a new Ras-signaling inhibitor.
ASDAS, BASDAI and different treatment responses and their relation to biomarkers of inflammation, cartilage and bone turnover in patients with axial spondyloarthritis treated with TNF? inhibitors.
Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.
Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer.
Association of matrix metalloproteinase-1 and -3 promoter polymorphisms with clinical subsets of Norwegian primary sclerosing cholangitis patients.
Association of matrix metalloproteinase-3 -1171(5A>6A) polymorphism with cancer risk: a meta-analysis of 41 studies.
Association of Oral Cavity and Oropharyngeal Cancer Biomarkers in Surgical Drain Fluid With Patient Outcomes.
Association of tumor necrosis factor-? and matrix metalloproteinase-3 gene variants with stroke.
Atherosclerotic plaque identification by virtual histology intravascular ultrasound in a rabbit abdominal aorta model of vulnerable plaque.
Atsttrin reduces lipopolysaccharide-induced neuroinflammation by inhibiting the nuclear factor kappa B signaling pathway.
Attachment to laminin-111 facilitates transforming growth factor beta-induced expression of matrix metalloproteinase-3 in synovial fibroblasts.
Autoantibody and Biopsy Grading Are Associated with Expression of ICAM-1, MMP-3, and TRAIL in Salivary Gland Mononuclear Cells of Chinese Patients with Sjogren's Syndrome.
Autocrine and paracrine regulation of tissue inhibitor of metalloproteinases, transin, and urokinase gene expression in metastatic and nonmetastatic mammary carcinoma cells.
Autocrine motility factor stimulates the invasiveness of malignant cells as well as up-regulation of matrix metalloproteinase-3 expression via a MAPK pathway.
Bioactive secondary metabolites from acid mine waste extremophiles.
Biological implications of growth factors on the mechanism of invasion in gynecological tumor cells.
Biomarkers for diagnosing and monitoring autoimmune diseases.
Biomarkers of inflammation and hemostasis associated with left ventricular mass: The Multiethnic Study of Atherosclerosis (MESA).
Black tea theaflavins attenuate Porphyromonas gingivalis virulence properties, modulate gingival keratinocyte tight junction integrity and exert anti-inflammatory activity.
Blockade of tumor necrosis factor-alpha-converting enzyme improves experimental small intestinal damage by decreasing matrix metalloproteinase-3 production in rats.
Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model.
Borrelia burgdorferi-induced expression of matrix metalloproteinases from human chondrocytes requires mitogen-activated protein kinase and Janus kinase/signal transducer and activator of transcription signaling pathways.
Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells.
Cancer biology: extracellular proteinases in malignancy.
Cancer-Specific Survival Stratification Derived from Tumor Expression of Tissue Inhibitor of Metalloproteinase-2 in Non-Metastatic Renal Cell Carcinoma.
Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke.
Canine Natural Killer Cell-Derived Exosomes Exhibit Antitumor Activity in a Mouse Model of Canine Mammary Tumor.
Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis.
Carnosine Prevents Type 2 Diabetes-Induced Osteoarthritis Through the ROS/NF-?B Pathway.
Case of primary malignant hemangiopericytoma of the heart expressing basement membrane-degradable enzymes.
Cathepsin G and alpha 1-antichymotrypsin in the local host reaction to loosening of total hip prostheses.
CCAAT/Enhancer Binding Protein ?-Mediated MMP3 Upregulation Promotes Esophageal Squamous Cell Cancer Invasion In Vitro and Is Associated with Metastasis in Human Patients.
CCL20 Stimulates Proinflammatory Mediator Synthesis in Human Fibroblast-like Synoviocytes Through a MAP Kinase-dependent Process with Transcriptional and Posttranscriptional Control.
CCR5 silencing reduces inflammatory response, inhibits viability, and promotes apoptosis of synovial cells in rat models of rheumatoid arthritis through the MAPK signaling pathway.
CD11c+ macrophages and levels of TNF-? and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidemia.
Celecoxib does not affect the release of hyaluronic acid in end stage osteoarthritic joints.
Cell-based gene therapy modifies matrix remodeling after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3-deficient mice.
Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.
Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression.
Changes in biomarkers of inflammation and bone turnover and associations with clinical efficacy following infliximab plus methotrexate therapy in patients with early rheumatoid arthritis.
Changes of synovial fluid biomarker levels after opening wedge high tibial osteotomy in patients with knee osteoarthritis.
Characterization of gene expression induced by RET with MEN2A or MEN2B mutation.
Characterization of phosphoglycerate kinase-1 expression of stromal cells derived from tumor microenvironment in prostate cancer progression.
Chemokine profile of disc degeneration with acute or chronic pain.
Cinnamomulactone, a new butyrolactone from the twigs of Cinnamomum cassia and its inhibitory activity of matrix metalloproteinases.
Circ-Sirt1 inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes.
Circulating levels of interleukin-6, vascular endothelial growth factor, YKL-40, matrix metalloproteinase-3, and total aggrecan in spondyloarthritis patients during 3 years of treatment with TNF? inhibitors.
Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts.
Collagen induced arthritis: reversal by mercaptoethylguanidine, a novel antiinflammatory agent with a combined mechanism of action.
Collagenase is expressed by rabbit VX2 tumour cells in syngeneic and xenogeneic hosts.
Collagenase-1, stromelysin-1 and 92 kDa gelatinase are associated with tumor necrosis factor-alpha induced morphological change of human endothelial cells in vitro.
Comparison of interface membranes obtained from failed cemented and cementless hip and knee prostheses.
Constitutive expression and secretion of proteases in non-metastatic SP1 mammary carcinoma cells and its metastatic sublines.
Constitutive migration and expression of three protease systems define in vitro the malignant phenotype of Ha-ras transformed rat liver epithelial cells.
Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes.
Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models.
Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK.
Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene.
CXCR7 protein expression correlates with elevated mmp-3 secretion in breast cancer cells.
Cyclophilin C-associated protein is a mediator for fibronectin fragment-induced matrix metalloproteinase-13 expression.
Cytokine inducible matrix metalloproteinase expression in immortalized rat chondrocytes is independent of nitric oxide stimulation.
Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion.
Cytokines in fluids from polycystic kidneys.
Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients.
Decrease of CD68 and MMP-3 expression in synovium by treatment of adalimumab for rheumatoid arthritis.
Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis.
Detection and localization of mRNAs encoding matrix metalloproteinases and their tissue inhibitor in human breast pathology.
Detection of mRNAs encoding collagenase I and stromelysin 2 in carcinomas of the head and neck by in situ hybridization.
Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: Sustained release of a local antiinflammatory therapeutic.
Development of recombinant matrix metalloproteinase-3 based sandwich ELISA for sero-diagnosis of canine mammary carcinomas.
Dexamethasone attenuation of cytokine-mediated articular cartilage degradation in experimental lapine Haemophilus arthritis.
Differential gene expression during multistage carcinogenesis.
Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers.
Differential regulation of MMP-9 and TIMP-2 expression in malignant melanoma developed in metallothionein/RET transgenic mice.
Differential Wnt pathway gene expression and E-cadherin truncation in sporadic colorectal cancers with and without microsatellite instability.
Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression.
Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia.
Drosophila TIMP is a potent inhibitor of MMPs and TACE: similarities in structure and function to TIMP-3.
Early detection of head and neck cancer: development of a novel screening tool using multiplexed immunobead-based biomarker profiling.
Effect of ?-anhydroicaritin on the expression levels of tumor necrosis factor-? and matrix metalloproteinase-3 in periodontal tissue of diabetic rats.
Effect of a small molecule inhibitor of nuclear factor-kappaB nuclear translocation in a murine model of arthritis and cultured human synovial cells.
Effect of body-weight loading onto the articular cartilage on the occurrence of quinolone-induced chondrotoxicity in juvenile rats.
Effect of Chondroitin Sulphate on Pro-Inflammatory Mediators and Disease Activity in Patients with Inflammatory Bowel Disease.
Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain.
Effect of IL-13 on cytokines, cytokine receptors and inhibitors on human osteoarthritis synovium and synovial fibroblasts.
Effect of matrix metalloproteinase inhibitors on tumor growth and spontaneous metastasis.
Effect of Moxibustion on the Serum Levels of MMP-1, MMP-3, and VEGF in Patients with Rheumatoid Arthritis.
Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines.
Effect of Proinflammatory Gene Polymorphisms on the Risk of Alzheimer's Disease.
Effects of Alpha-Lipoic Acid Supplementation on Inflammatory Biomarkers and Matrix Metalloproteinase-3 in Rheumatoid Arthritis Patients.
Effects of chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor binding.
Effects of Cytokine Activation and Oxidative Stress on the Function of the Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.
Effects of dexmedetomidine on glioma cells in the presence or absence of cisplatin.
Effects of exercise therapy on knee joint function and synovial fluid cytokine levels in patients with knee osteoarthritis.
Effects of JNK1/2 on the inflammation cytokine TNF-?-enhanced production of MMP-3 in human dental pulp fibroblast-like cells.
Effects of rambutan (Nephelium lappaceum) peel phenolics and Leu-Ser-Gly-Tyr-Gly-Pro on hairless mice skin photoaging induced by ultraviolet irradiation.
Effects of sex steroids and growth factors on invasive activity and 5'-deoxy-5-fluorouridine sensitivity in ovarian adenocarcinoma OMC-3 cells.
Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts.
Efficient purification of TIMP-2 from culture medium conditioned by human hepatoma cell line, and its inhibitory effects on metalloproteinases and in vitro tumor invasion.
Electroacupuncture Delays Cartilage Degeneration by Modulating Nuclear Factor-?B Signaling Pathway.
Elevated expression of matrix metalloproteinase-3 in human osteosarcoma and its association with tumor metastasis.
Elevated interleukin-12 in pseudosynovial fluid in patients with aseptic loosening of hip prosthesis.
Elevated plasma stromelysin levels in arthritis.
EMMPRIN-mediated MMP regulation in tumor and endothelial cells.
Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model.
Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma.
Enhanced production of matrix metalloproteinases and activation of matrix metalloproteinase 2 (gelatinase A) in human gastric carcinomas.
Enhanced tendon restoration effects of anti-inflammatory, lactoferrin-immobilized, heparin-polymeric nanoparticles in an Achilles tendinitis rat model.
Epithelial cells up-regulate matrix metalloproteinases in cells within the same mammary carcinoma that have undergone an epithelial-mesenchymal transition.
Euodia pasteuriana Methanol Extract Exerts Anti-Inflammatory Effects by Targeting TAK1 in the AP-1 Signaling Pathway.
Evaluation of the post-treatment anti-inflammatory capacity of osteoarthritic chondrocytes: An in vitro study using baicalein.
Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells.
Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration.
Exposure of cartilage to a fibronectin fragment amplifies catabolic processes while also enhancing anabolic processes to limit damage.
Expression and characterization of a novel recombinant cytotoxin II from Naja naja oxiana venom: A potential treatment for breast cancer.
Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small-cell lung cancer.
Expression of ?v?6 integrin and collagen fibre in oral squamous cell carcinoma: association with clinical outcomes and prognostic implications.
Expression of c-erbB receptors, MMPs and VEGF in squamous cell carcinoma of the head and neck.
Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
Expression of collagenase-related metalloproteinase genes in human lung or head and neck tumours.
Expression of ets-1 transcription factor in human head and neck squamous cell carcinoma and effect of histamine on metastatic potential of invasive tumor through the regulation of expression of ets-1 and matrix metalloproteinase-3.
Expression of genes encoding type IV collagen-degrading metalloproteinases and tissue inhibitors of metalloproteinases in various human tumor cells.
Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis.
Expression of matrix metalloproteinase-3 in stage I and II squamous cell carcinoma of the oral cavity.
Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression.
Expression of metalloproteinases and their inhibitors in adenocarcinoma of the uterine cervix.
Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis.
Expression of metalloproteinases endometrial stromal sarcoma: immunohistochemical study using image analysis.
Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance.
Expression of microRNA-21 and TIMP-3 in paradoxical psoriasiform reactions during treatment with antitumor necrosis factor agents.
Expression of MMP-2 and TIMP-3 with incidence and prognosis of giant-cell tumor of the bone.
Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.
Expression of stromelysin 1 in human astrocytoma cell lines.
Expression of stromelysin 3 in the stromal elements of human basal cell carcinoma.
Expression of stromelysin-1 and TIMP-1 in the involuting mammary gland and in early invasive tumors of the mouse.
Expression of the IL-6 family cytokines in human brain tumors.
Expression of the transcription factor c-Ets1 correlates with the occurrence of invasive processes during normal and pathological development.
Expression of the transin, c-fos, and c-jun genes in rat transplantable osteosarcomas and malignant fibrous histiocytomas.
Expression of TNF-?, VEGF, and MMP-3 mRNAs in synovial tissues and their roles in fibroblast-mediated osteogenesis in ankylosing spondylitis.
Expression pattern and circulating levels of endostatin in patients with pancreas cancer.
Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression.
Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells.
Expressions of matrix metalloproteinase-9 (MMP-9), dentin sialophosphoprotein (DSPP), and osteopontin (OPN) at histologically negative surgical margins may predict recurrence of oral squamous cell carcinoma.
Extracellular matrix remodeling as a regulator of stromal-epithelial interactions during mammary gland development, involution and carcinogenesis.
Fibronectin and cytokines increase JNK, ERK, AP-1 activity, and transin gene expression in rat hepatic stellate cells.
Fibronectin III 13-14 domains induce joint damage via Toll-like receptor 4 activation and synergize with interleukin-1 and tumour necrosis factor.
Fire acupuncture for mild to moderate knee osteoarthritis: a protocol for a randomized controlled pilot trial.
Galectin-3 deficiency protects lipopolysaccharide-induced chondrocytes injury via regulation of TLR4 and PPAR-?-mediated NF-?B signaling pathway.
Gene expression of matrix metalloproteinase-1 (interstitial collagenase) and matrix metalloproteinase-3 (stromelysin-1) in basal cell carcinoma by in situ hybridization using chondroitin ABC lyase.
Genipin inhibits MMP-1 and MMP-3 release from TNF-a-stimulated human periodontal ligament cells.
Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1? in osteoarthritic osteoblasts.
Heterogeneous regional expression patterns of matrix metalloproteinases in human malignant gliomas.
Heterozygosity of stromelysin-1 (rs3025058) promoter polymorphism is associated with gastric cancer.
High expression levels of collagenase-1 and stromelysin-1 correlate with shorter disease-free survival in human metastatic melanoma.
High levels of tissue inhibitor of metalloproteinase-1 predict poor outcome in patients with breast cancer.
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
High serum matrix metalloproteinase 3 is characteristic of patients with paraneoplastic remitting seronegative symmetrical synovitis with pitting edema syndrome.
High-Frequency Near-Infrared Diode Laser Irradiation Attenuates IL-1?-Induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes.
High-throughput functional profiling of single adherent cells via hydrogel drop-screen.
Histological analysis of synovium by treatment of etanercept for rheumatoid arthritis.
Histological analysis of synovium in cases of effect attenuation associated with infliximab therapy in rheumatoid arthritis.
Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases.
Human collagenase-3 is expressed in malignant squamous epithelium of the skin.
Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer.
Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89.
Human vascular smooth muscle cell-monocyte interactions and metalloproteinase secretion in culture.
Hyaluronan Up-Regulates IL-10 Expression in Fibroblast-Like Synoviocytes from Patients with Tibia Plateau Fracture.
Hydrostatic pressure induces expression of interleukin 6 and tumour necrosis factor alpha mRNAs in a chondrocyte-like cell line.
Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3).
Identification of self-epitopes recognized by T cells in rheumatoid arthritis demonstrates matrix metalloproteinases as a novel T cell target.
IL-20 may contribute to the pathogenesis of human intervertebral disc herniation.
Immunohistochemical expression of matrix metalloproteinases 1, 2, 9, and 14 in dermatofibrosarcoma protuberans and common fibrous histiocytoma (dermatofibroma).
Immunohistological analysis of synovium treated with abatacept in rheumatoid arthritis.
Immunolocalization of matrix metallo-proteinases and their tissue inhibitor in human mammary pathology.
Immunolocalization of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas.
Immunolocalization of selected cytokines and proteases in canine articular cartilage after transarticular loading.
Immunolocalization of stromelysin, tumor necrosis factor (TNF) alpha, and TNF receptors in atrophied canine articular cartilage treated with hyaluronic acid and transforming growth factor beta.
In vitro and in vivo matrix metalloproteinase expression after photodynamic therapy with a liposomal formulation of aminolevulinic acid and its methyl ester.
In vitro effects of meloxicam on metabolism in articular chondrocytes from dogs with naturally occurring osteoarthritis.
Increased backbone mobility in beta-barrel enhances entropy gain driving binding of N-TIMP-1 to MMP-3.
Increased elastic modulus of the synovial membrane in a rat ACLT model of osteoarthritis revealed by atomic force microscopy.
Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas.
Increased expression of matrix metalloproteinase-3 (stromelysin-1) in cultured fibroblasts and basal cell carcinomas of nevoid basal cell carcinoma syndrome.
Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone.
Increased matrix metalloproteinase activation in esophageal squamous cell carcinoma.
Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis.
Increased plasma MMP-2 protein expression in lymph node-positive patients with colorectal cancer.
Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease.
Increased serum PCSK9, a potential biomarker to screen for periodontitis, and decreased total bilirubin associated with probing depth in a Japanese community survey.
Increases of stromelysin messenger-RNA expression in ras-transformed ref cells in-vivo.
Induction of hepatoma cells migration by phosphoglucose isomerase/autocrine motility factor through the upregulation of matrix metalloproteinase-3.
Induction of macrophage matrix metalloproteinase biosynthesis by surfactant protein D.
Induction of matrix metalloproteinase gene expression in an endothelial cell line by direct interaction with malignant cells.
Induction of stromelysin gene expression by tumor necrosis factor alpha is inhibited by dexamethasone, salicylate, and N-acetylcysteine in synovial fibroblasts.
Induction of stromelysin-1 and collagenase synthesis in fibrochondrocytes by tumor necrosis factor-alpha.
Inflammation suppression by dexamethasone via inhibition of CD147-mediated NF-?B pathway in collagen-induced arthritis rats.
Inflammatory Cytokine Expression and Sebum Production after Exposure of Cultured Human Sebocytes to Ultraviolet A Radiation and Light at Wavelengths of 650 nm and 830 nm.
Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture.
Inflammatory cytokines and matrix metalloproteinases in the synovial fluid after intra-articular elbow fracture.
Influence of the Molecular Weight of Poly(Lactide-Co-Glycolide) on the In Vivo Cartilage Repair by a Construct of Poly(Lactide-Co-Glycolide)/Fibrin Gel/Mesenchymal Stem Cells/Transforming Growth Factor-?1.
Inhibition of human MDA-MB-231 breast cancer cell invasion by matrix metalloproteinase 3 involves degradation of plasminogen.
Inhibition of JNK in synovium by treatment with golimumab in rheumatoid arthritis.
Inhibition of MAP kinase in synovium by treatment with tocilizumab in rheumatoid arthritis.
Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids.
Inhibition of tumor growth and induction of apoptosis in prostate cancer cell lines by overexpression of tissue inhibitor of matrix metalloproteinase-3.
Insights into the distinct roles of MMP-11 in tumor biology and future therapeutics (Review).
Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment.
Interactions of alpha2-HS-glycoprotein (fetuin) with MMP-3 and murine squamous cell carcinoma cells.
Interferon-? protects first-trimester decidual cells against aberrant matrix metalloproteinases 1, 3, and 9 expression in preeclampsia.
Interferon-beta induces metalloproteinase mRNA expression in human fibroblasts. Role of activator protein-1.
Interleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1.
Interleukin-12 deficiency is permissive for angiogenesis in UV radiation-induced skin tumors.
Interleukin-1beta induced activation of nuclear factor-kappab can be inhibited by novel pharmacological agents in osteoarthritis.
Interleukin-4 (IL-4) induces down-modulation and shedding of the p55 tumour necrosis factor receptor and inhibits TNF alpha's effect on rheumatoid synovial fibroblasts.
Interleukin-6 involvement in brain arteriovenous malformations.
Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells.
Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function.
Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion.
Invasive tumors induce c-ets1 transcription factor expression in adjacent stroma.
Investigation of Cytokine Changes in Osteoarthritic Knee Joint Tissues in Response to Hyperacute Serum Treatment.
Investigation of the role of MMP3 -1171insA polymorphism in cutaneous malignant melanoma - a preliminary study.
Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy.
Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice.
Isolation and characterization of human monoclonal antibodies specific to MMP-1A, MMP-2 and MMP-3.
Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts.
Isolation, characterization, and expression of feline stromelysin-1 in naturally developing tumors in cats.
Isolation, characterization, and expression of stromelysin-1 in primary tumors of dogs.
Kadsura heteroclita stem suppresses the onset and progression of adjuvant-induced arthritis in rats.
Kaempferitrin inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes.
Keratinocyte-derived cytokines after photodynamic therapy and their paracrine induction of matrix metalloproteinases in fibroblasts.
l-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes.
LINC00963 affects the development of colorectal cancer via MiR-532-3p/HMGA2 axis.
LINC01534 Promotes the Aberrant Metabolic Dysfunction and Inflammation in IL-1?-Simulated Osteoarthritic Chondrocytes by Targeting miR-140-5p.
Lipoma arborescens co-existing with psoriatic arthritis releases tumour necrosis factor alpha and matrix metalloproteinase 3.
Loss of JunB activity enhances stromelysin 1 expression in a model of the epithelial-to-mesenchymal transition of mouse skin tumors.
Macrophages regulate tumor necrosis factor-alpha expression in adipocytes through the secretion of matrix metalloproteinase-3.
Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1.
Mast cells, cytokines, and metalloproteinases at the rheumatoid lesion: dual immunolocalisation studies.
Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis.
Matrix metalloproteases and TIMPs as prognostic biomarkers in breast cancer patients treated with radiotherapy: A pilot study.
Matrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: evidence for the role of TNF-alpha and cyclooxygenase-2.
Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.
Matrix metalloproteinase and its drug targets therapy in solid and hematological malignancies: An overview.
Matrix metalloproteinase expression in human breast cancer: an immunohistochemical study including correlation with cathepsin D, type IV collagen, laminin, fibronectin, EGFR, c-erbB-2 oncoprotein, p53, steroid receptors status and proliferative indices.
Matrix Metalloproteinase Expressions Play Important role in Prediction of Ovarian Cancer Outcome.
Matrix metalloproteinase inhibition facilitates cell death in intracerebral hemorrhage in mouse.
Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material.
Matrix metalloproteinase production by cultured human endometrial stromal cells: identification of interstitial collagenase, gelatinase-A, gelatinase-B, and stromelysin-1 and their differential regulation by interleukin-1 alpha and tumor necrosis factor-alpha.
Matrix metalloproteinase-1 and -3 in breast cancer: correlation with progesterone receptors and other clinicopathologic features.
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.
Matrix metalloproteinase-3 in the central nervous system: a look on the bright side.
Matrix Metalloproteinase-3 is Key Effector of TNF-?-Induced Collagen Degradation in Skin.
Matrix metalloproteinase-3 secretion from human pancreatic periacinar myofibroblasts in response to inflammatory mediators.
Matrix metalloproteinase-9,-3 and tissue inhibitor of matrix metalloproteinase-1 in colorectal cancer: relationship to clinicopathological variables.
Matrix metalloproteinase-induced fibrosis and malignancy in breast and lung.
Matrix metalloproteinases and their inhibitors in gastric cancer.
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas.
Matrix metalloproteinases in blood vessel development in human fetal skin and in cutaneous tumors.
Matrix metalloproteinases play an active role in Wnt1-induced mammary tumorigenesis.
Matrix metalloproteinases, their tissue inhibitors and colorectal cancer staging.
Matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases and angiogenic cytokines in peripheral blood of patients with thyroid cancer.
Matrix-degrading metalloproteinases in tumor progression.
Matrix-metalloproteinases 1, 2, and 3 and their tissue inhibitors 1 and 2 in benign and malignant breast lesions: an in situ hybridization study.
Measurement of inflammatory biomarkers in synovial tissue extracts by enzyme-linked immunosorbent assay.
Mechanism of signal transduction in tumor necrosis factor-like weak inducer of apoptosis-induced matrix degradation by MMP-3 upregulation in disc tissues.
Mechanistic Insights into Side Effects of Troglitazone and Rosiglitazone Using a Novel Inverse Molecular Docking Protocol.
Mediation of laser trabeculoplasty-induced matrix metalloproteinase expression by IL-1beta and TNFalpha.
Mesenchymal stromal cells versus betamethasone can dampen disease activity in the collagen arthritis mouse model.
Metaanalysis of the significance of matrix metalloproteinases for lymph node disease in patients with head and neck squamous cell carcinoma.
Metalloprotease activity, phospholipase A2 activity and cytokine concentration in osteoarthritis synovial fluids.
Metalloproteinase and TIMP expression by the human breast carcinoma cell line 8701-BC.
Metalloproteinases 1 and 3 as Potential Biomarkers in Breast Cancer Development.
Microdermabrasion with and without aluminum oxide crystal abrasion: a comparative molecular analysis of dermal remodeling.
Microdermabrasion: a molecular analysis following a single treatment.
MicroRNA-18a-5p Suppresses Tumor Growth via Targeting Matrix Metalloproteinase-3 in Cisplatin-Resistant Ovarian Cancer.
MicroRNA-21-5p are involved in apoptosis and invasion of fibroblast-like synoviocytes through PTEN/PI3K/AKT signal.
Mid-trimester amniotic fluid pro-inflammatory biomarkers predict the risk of spontaneous preterm delivery in twins: a retrospective cohort study.
Minimally invasive colorectal resection is associated with significantly elevated levels of plasma matrix metalloproteinase 3 (MMP-3) during the first month after surgery which may promote the growth of residual metastases.
MIR-140-5p affects chondrocyte proliferation, apoptosis, and inflammation by targeting HMGB1 in osteoarthritis.
miR-522 Modulated the Expression of Proinflammatory Cytokines and Matrix Metalloproteinases Partly via Targeting Suppressor of Cytokine Signaling 3 in Rheumatoid Arthritis Synovial Fibroblasts.
Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties.
MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues.
MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment.
MMP-3 mRNA and MMP-3 and MMP-1 proteins in bladder cancer: a comparison with clinicopathologic features and survival.
MMP3 and CXCL1 are potent stromal protein markers of dysplasia-carcinoma transition in sporadic colorectal cancer.
Molecular determinants of glioma cell migration and invasion.
Molecular mechanisms of malignant conversion in skin carcinogenesis.
Molecular regulation of ovarian cancer cell invasion.
Monoclonal antibodies against human collagenase and stromelysin.
mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas.
mu-Calpain is involved in the regulation of TNF-alpha-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line.
Myelin Loss Associated With Neuroinflammation in Hypertensive Rats.
Negative regulation of gene expression by TGF-beta.
NFAT1 directly regulates IL-8 and MMP-3 to promote melanoma tumor growth and metastasis.
Nitric oxide activates metalloprotease enzymes in articular cartilage.
NLRP3 as a potentially novel biomarker for the management of osteoarthritis.
No association between the polymorphisms in matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter regions and colorectal cancer in chinese.
Nobiletin alleviates endometriosis via down-regulating NF-?B activity in endometriosis mouse model.
Norepinephrine from synovial tyrosine hydroxylase positive cells is a strong indicator of synovial inflammation in rheumatoid arthritis.
Notch3 promotes prostate cancer-induced bone lesion development via MMP-3.
Novel Anti-arthritic Mechanisms of Polydatin in Complete Freund's Adjuvant-Induced Arthritis in Rats: Involvement of IL-6, STAT-3, IL-17, and NF-?B.
Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway.
Oral infection with Porphyromonas gingivalis and systemic cytokine profile in C57BL/6.KOR-ApoE(shl) mice.
Osteoarthritis-related biomarkers profile in chronic anterior cruciate ligament injured knee.
Overexpression of MMP-3 and uPA with Diminished PAI-1 Related to Metastasis in Ductal Breast Cancer Patients Attending a Public Hospital in Mexico City.
Overexpression of protein kinase C-alpha and -beta isozymes by stromal dendritic cells in basal and squamous cell carcinoma.
p38 MAP kinase pathway and stromelysin regulation in trabecular meshwork cells.
Pachymic acid modified carbon nanoparticles reduced angiogenesis via inhibition of MMP-3.
Parthenolide inhibits pro-inflammatory cytokine production and exhibits protective effects on progression of collagen-induced arthritis in a rat model.
Phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor BAY 12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies.
Phase I study of the matrix metalloproteinase inhibitor, BAY 12-9566.
Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein.
Phospholipase Cgamma1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade.
Physiological mechanisms for metalloproteinase activation.
Plasma Level of MMP-10 May Be a Prognostic Marker in Early Stages of Breast Cancer.
Plasma matrix metalloproteinases, cytokines and angiogenic factors in moyamoya disease.
Porphyromonas gingivalis lipids inhibit osteoblastic differentiation and function.
Production of cytokines by chondrocytes and its role in proteoglycan degradation.
Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas.
Production of matrix metalloproteinases in specific subpopulations of human-patient breast cancer invading in three dimensional culture system.
Profibrotic phenotype of conjunctival fibroblasts from mucous membrane pemphigoid.
Profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases proteins in bladder urothelial carcinoma.
Prognostic Impact of Tissue Inhibitor of Metalloproteinase-1 in Non-Small Cell Lung Cancer: Systematic Review and Meta-Analysis.
Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer.
Prognostic values of ETS-1, MMP-2 and MMP-9 expression and co-expression in breast cancer patients.
Proinflammatory cytokine activities, matrix metalloproteinase-3 activity, and sulfated glycosaminoglycan content in synovial fluid of dogs with naturally acquired cranial cruciate ligament rupture.
Proinflammatory Cytokines and Chemokines as Biomarkers of Persistent Arthralgia and Severe Disease After Chikungunya Virus Infection: A 5-Year Follow-Up Study in Southern Thailand.
Proinflammatory cytokines induce stromelysin-1-mediated cell proliferation in dental pulp fibroblast-like cells.
Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes.
Prostate cancer-derived MMP-3 controls intrinsic cell growth and extrinsic angiogenesis.
Prostate tumor cell invasion: a comparison of orthotopic and ectopic models.
Protective Effect of Super-Critical Carbon Dioxide Fluid Extract from Flowers and Buds of Chrysanthemum indicum Linnén Against Ultraviolet-Induced Photo-Aging in Mice.
Protective effects of cilengitide on inflammation in chondrocytes under excessive mechanical stress.
Protein kinase C isotypes required for phorbol-ester induction of stromelysin-1 in rat fibroblasts.
Protein kinase C-independent expression of stromelysin by platelet-derived growth factor, ras oncogene, and phosphatidylcholine-hydrolyzing phospholipase C.
Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-? and bradykinin in human colonic myofibroblasts.
Protein kinase regulation of tumor necrosis factor alpha stimulated collagenase and stromelysin message levels in chondrocytes.
Proteinases, their inhibitors, and cytokine profiles in acute wound fluid.
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines.
Proteolysis in human breast and colorectal cancer.
Proteolysis of the matricellular protein hevin by matrix metalloproteinase-3 produces a SPARC-like fragment (SLF) associated with neovasculature in a murine glioma model.
Proteolyzed matrix as a template for the regulation of tumor progression.
Pulsed Electromagnetic Field Modulates Tendon Cells Response in IL-1?-Conditioned Environment.
Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members.
Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line.
Purification of a gelatin-degrading type IV collagenase secreted by ras oncogene-transformed fibroblasts.
Quantification of matrix metalloproteinase activity in plasma of patients enrolled in a BAY 12-9566 phase I study.
Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor ? inhibitors: a study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover.
Reactive oxygen species-mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression.
Recapitulation of a normal cellular growth program in early invasive breast-cancer.
Redox regulation of MMP-3/TIMP-1 ratio in intestinal myofibroblasts: Effect of N-acetylcysteine and curcumin.
Regulation of collagenase, stromelysin, and gelatinase B in human conjunctival and conjunctivochalasis fibroblasts by interleukin-1beta and tumor necrosis factor-alpha.
Regulation of expression of stromyelysin-1 by proinflammatory cytokines in mouse brain astrocytes.
Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes: a role for CD40 signaling in plaque rupture?
Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor alpha, interleukin 1 and phorbol ester.
Regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) by bone resorptive factors in osteoblastic cells.
Regulation of matrix metalloproteinases and plasminogen activator inhibitor-1 synthesis by plasminogen in cultured human vascular smooth muscle cells.
Regulation of matrix metalloproteinases: an overview.
Relationships between early inflammatory response to bleomycin and sensitivity to lung fibrosis: a role for dipeptidyl-peptidase I and tissue inhibitor of metalloproteinase-3?
Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.
Remitting seronegative symmetrical synovitis with pitting edema syndrome complicated with primary lung cancer.
Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study.
Resveratrol inhibits matrix metalloproteinase-1 and -3 expression by suppressing of p300/NF?B acetylation in TNF-?-treated human dermal fibroblasts.
Retroviral vector-producer cell-mediated in vivo gene transfer of TIMP-3 restricts angiogenesis and neuroblastoma growth in mice.
Roflumilast prevents lymphotoxin ? (TNF-?)-induced inflammation activation and degradation of type 2 collagen in chondrocytes.
Role of MMP-3 and MMP-9 and their haplotypes in risk of bladder cancer in North Indian cohort.
Screening of stress enhancer based on analysis of gene expression profiles: enhancement of hyperthermia-induced tumor necrosis by an MMP-3 inhibitor.
Selective cleavage of human IgG by the matrix metalloproteinases, matrilysin and stromelysin.
Sensitive electrochemical immunosensor for matrix metalloproteinase-3 based on single-wall carbon nanotubes.
Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene.
Sequential dynamics of inflammatory cytokine, angiogenesis inducing factor and matrix degrading enzymes during spontaneous resorption of the herniated disc.
Serum and Saliva MMP-3 in Patients with OLP and Oral SCC.
Serum and synovial fluid concentrations of matrix metalloproteinases 3 and its tissue inhibitor 1 in juvenile idiopathic arthritides.
Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases.
Serum matrix metalloproteinase-3 (stromelysin-1) concentration in patients with chronic liver disease.
Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in patients with malignant melanoma.
Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis.
Serum metalloproteinases and their inhibitors: markers for malignant potential.
Signal pathways involved in the production of MMP-1 and MMP-3 in human gingival fibroblasts.
Signal transducer and activator of transcription 1 and matrix metalloproteinase 3 genetic expression and clinical significance on urothelial tumors after renal transplantation.
Simultaneous presence of unsaturation and long alkyl chain at P'1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies.
Small integrin binding ligand N-linked glycoprotein gene family expression in different cancers.
Smooth Muscle Peroxisome Proliferator-Activated Receptor ? Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo.
Soluble biomarkers may differentiate psoriasis from psoriatic arthritis.
Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor.
Solution structures of stromelysin complexed to thiadiazole inhibitors.
Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44.
Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism.
Spontaneous and cytokine induced expression and activity of matrix metalloproteinases in human colonic epithelium.
Spontaneous and cytokine induced expression and activity of matrix metalloproteinases in human colonic epithelium.
Spontaneous metastasis in matrix metalloproteinase 3-deficient mice.
SPR Biosensing in crude serum using ultralow fouling binary patterned peptide SAM.
Steady-state mRNA levels of interleukin-1, integrins, cJun, and cFos in hairless mouse skin during short-term chronic UV exposure and the effect of topical tretinoin.
Stress-induced cartilage degradation does not depend on NLRP3 inflammasome in osteoarthritis.
Stromal expression of c-Ets1 transcription factor correlates with tumor invasion.
Stromelysin (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase (TIMP-1) mRNA expression in scleritis.
Stromelysin in tumor progression and metastasis.
Stromelysin-1 (MMP-3) is inducible in T lymphoma cells and accelerates the growth of lymphoid tumors in vivo.
Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells.
Stromelysin-1 expression is activated in vivo by Ets-1 through palindromic head-to-head Ets binding sites present in the promoter.
Stromelysin-1 promoter mutations impair gelatinase B activation in high microsatellite instability sporadic colorectal tumors.
Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme.
Structural studies of the MMP-3 interaction with triple-helical collagen introduce new roles for the enzyme in tissue remodelling.
Structure and expression of the human gene for the matrix metalloproteinase matrilysin.
Sudachitin Inhibits Matrix Metalloproteinase-1 and -3 Production in Tumor Necrosis Factor-?-Stimulated Human Periodontal Ligament Cells.
Suppression of hyaluronan synthesis alleviates inflammatory response in murine arthritis and in human rheumatoid synovial fibroblasts.
Synergistic effect of l-ascorbic acid and hyaluronic acid on the expressions of matrix metalloproteinase-3 and -9 in human chondrocytes.
Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not.
Synovial Fluid Profile at the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery.
Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model.
Systemic Th17-like cytokine pattern in gangrenous appendicitis but not in phlegmonous appendicitis.
Taraxasterol suppresses inflammation in IL-1?-induced rheumatoid arthritis fibroblast-like synoviocytes and rheumatoid arthritis progression in mice.
Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes.
TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1.
The 5A/6A polymorphism of the matrix metalloproteinase 3 gene promoter and breast cancer.
The association of MMP-1, -3 and -9 genotypes with the prognosis of HCV-related hepatocellular carcinoma patients.
The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.
The cellular response to induction of the p21 c-Ha-ras oncoprotein includes stimulation of jun gene expression.
The chondroprotective drugs, Arteparon and sodium pentosan polysulphate, increase collagenase activity and inhibit stromelysin activity in vitro.
The collagenase gene family in humans consists of at least four members.
The complexity of molecular processes in osteoarthritis of the knee joint.
The distribution of matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal cancer.
The effects of dopamine receptor 2 expression on B cells on bone metabolism and TNF-? levels in rheumatoid arthritis.
The expression of proinflammatory cytokines and matrix metalloproteinases in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders.
The IGF-I Receptor Can Alter the Matrix Metalloproteinase Repertoire of Tumor Cells through Transcriptional Regulation of PKC-{alpha}
The inhibitor of kappa B kinase-epsilon regulates MMP-3 expression levels and can promote lung metastasis.
The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter.
The matrix metalloproteinase system in oral squamous cell carcinoma.
The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.
The promoter polymorphism of the matrix metalloproteinase 3 (MMP-3) gene in women with ovarian cancer.
The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages.
The role of stromelysin-1 in stromal-epithelial interactions and cancer.
The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas.
The significance of epidermal growth factor receptor and matrix metalloproteinase-3 in squamous cell carcinoma of the oral cavity.
The Stromal Overexpression of CD10 in Invasive Breast Cancer and its Association with Clincophathologic Factors.
The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.
Therapeutic Effects of the Addition of Platelet-Rich Plasma to Bioimplants and Early Rehabilitation Exercise on Articular Cartilage Repair.
Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.
Thyroid hormone regulates stromelysin expression, protease secretion and the morphogenetic potential of normal polarized mammary epithelial cells.
Tissue distribution of major matrix metalloproteinases and their transcripts in human breast carcinomas.
Tissue inhibitor of matrix metalloproteinase-3 levels in the extracellular matrix of lung, kidney, and eye increase with age.
Tissue inhibitor of matrix metalloproteinases-3 (TIMP-3) lacks involvement in bacterial collagenase-induced intracerebral hemorrhage in mouse.
TNF-? induces phenotypic modulation in cerebral vascular smooth muscle cells: implications for cerebral aneurysm pathology.
TNIIIA2, The Peptide of Tenascin-C, as a Candidate for Preventing Articular Cartilage Degeneration.
Toll-Like Receptor 3 Deficiency Leads to Altered Immune Responses to Chlamydia trachomatis Infection in Human Oviduct Epithelial Cells.
Tranexamic acid has positive effect in early period of tendon healing by stimulating the tumor necrosis factor-alpha and matrix metalloproteinase-3 expression levels.
Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.
Transcriptional regulation of stromelysin-1 gene expression is altered during progression of mouse mammary epithelial cells from functionally normal to malignant.
Transforming growth factor beta 1 and cAMP inhibit transcription of epidermal growth factor- and oncogene-induced transin RNA.
Treatment with dextromethorphan improves endothelial function, inflammation and oxidative stress in male heavy smokers.
Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model.
Tripterygium wilfordii Hook F extract suppresses proinflammatory cytokine-induced expression of matrix metalloproteinase genes in articular chondrocytes by inhibiting activating protein-1 and nuclear factor-kappaB activities.
Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinoma.
Tumor cell-derived collagenase-stimulatory factor increases expression of interstitial collagenase, stromelysin, and 72-kDa gelatinase.
Tumor collagenase stimulatory factor (TCSF) expression and localization in human lung and breast cancers.
Tumor induced by Moloney sarcoma virus causes periosteal osteogenesis engaging osteopontin, fibronectin, stromelysin-1 and tenascin.
Tumor necrosis factor alpha and epidermal growth factor regulation of collagenase and stromelysin in adult porcine articular chondrocytes.
Tumor necrosis factor-?- and interleukin-1?-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-?B axis: implications in inflammatory disc disease.
Tumor necrosis factor-?-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo.
Tumor necrosis factor-alpha (TNF-alpha) in canine osteoarthritis: Immunolocalization of TNF-alpha, stromelysin and TNF receptors in canine osteoarthritic cartilage.
Tumor promoters induce a transient expression of tumor-associated genes in both basal and differentiated cells of the mouse epidermis.
Tumour necrosis factor-alpha mediates tumour promotion via a PKC alpha- and AP-1-dependent pathway.
Tumour-targeting properties of antibodies specific to MMP-1A, MMP-2 and MMP-3.
Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation.
Ultraviolet B radiation increases steady-state mRNA levels for cytokines and integrins in hairless mouse skin: modulation by topical tretinoin.
Unregulated and independent expression of collagenase and transin related to tumor progression.
Upregulation of caveolin-1 and CD147 expression in nasopharyngeal carcinoma enhanced tumor cell migration and correlated with poor prognosis of the patients.
Upregulation of serum vascular endothelial growth factor and matrix metalloproteinase-3 in patients with oral squamous cell carcinoma.
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
Usefulness of VEGF, MMP-2, MMP-3 and TIMP-2 serum level evaluation in patients with adrenal tumours.
Various modes of gene regulation by nuclear receptors for steroid and thyroid hormones.
Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes.
Venlafaxine alleviates complete Freund's adjuvant-induced arthritis in rats: Modulation of STAT-3/IL-17/RANKL axis.
Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element.
[(18)F-Fluorodeoxyglucose positron emission tomography and serum cytokines and matrix metalloproteinases in the assessment of disease activity in Takayasu's arteritis].
[Association of single nucleotide polymorphism in matrix metalloproteinases promoter with susceptibility to ovarian cancer]
[Changes in markers of proliferation, neoangiogenesis and plasminogen activation system in rectal cancer tissue].
[Clinical significance of functional variants of matrix metalloproteinase genes in thyroid cancer]
[Clinical study of etanercept for treating ankylosing spondylitis]
[Correlation analysis of bone marrow edema degree and serum inflammatory factors change with knee joint pain symptoms in patients with bone contusion around the knee joint].
[Cytokines, prostaglandin E2, phospholipase A and metalloproteases in synovial fluid in osteoarthritis]
[Detection of stromelysin mRNA expression in human hepatocellular carcinoma by in situ hybridization]
[Effect of fire needling on mild to moderate knee osteoarthritis and related serum inflammatory cytokines].
[Effect of Warm-needle-moxibustion on Behavior Reactions and TNF-? and MMP-3 Contents in Knee Cartilage of Rabbits with Knee Osteoarthritis].
[Effects of tumor necrosis factor-? on release of MMP-3, MMP-9, and interleukin-17 in mouse bone marrow-derived mast cells in vitro].
[Experimental study on replicating knee osteoarthritis by modified Hulth's modeling method]
[Expression of dishevelled-2 in cartilage of rheumatoid arthritis and its effect on cartilage destruction].
[Expression of matrix metalloproteinases in metastatic lesions of cutaneous squamous cell carcinoma]
[Role of matrix metalloproteinase-3 in joint destruction in rheumatoid arthritis]
[Roles of serine proteases and matrix metalloproteinases in tumor invasion and angiogenesis]
[Urothelial tumors and the extracellular matrix]
Nephritis
Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis.
Clinical significance of matrix metalloproteinase-3 in systemic lupus erythematosus patients: a potential biomarker for disease activity and damage.
The gene expression profile of matrix metalloproteinases and their inhibitors in children with Henoch-Schönlein purpura.
[Matrix metalloproteinase-3 in patients with systemic lupus erythematosus and its significance in differentiating disease activity from pulmonary infections].
Nephritis, Hereditary
Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome.
Stage-Specific Action of Matrix Metalloproteinases Influences Progressive Hereditary Kidney Disease.
Nephrosis
Effect of a specific endothelin receptor A antagonist and an angiotensin-converting enzyme inhibitor on glomerular mRNA levels for extracellular matrix components, metalloproteinases (MMP) and a tissue inhibitor of MMP in aminonucleoside nephrosis.
Nervous System Diseases
Matrix metalloproteinase-3 in myasthenia gravis compared to other neurological disorders and healthy controls.
Serum levels of matrix metalloproteinases: implications in clinical neurology.
Neuralgia
Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy.
Neuroblastoma
Angiogenesis inhibitors in a murine neuroblastoma model: quantitative assessment of intratumoral blood flow with contrast-enhanced gray-scale US.
Retroviral vector-producer cell-mediated in vivo gene transfer of TIMP-3 restricts angiogenesis and neuroblastoma growth in mice.
Neurodegenerative Diseases
Matrix metalloproteinase-3 in the central nervous system: a look on the bright side.
Matrix metalloproteinase-3 is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during ER stress.
MMP-3 contributes to nigrostriatal dopaminergic neuronal loss, BBB damage, and neuroinflammation in an MPTP mouse model of Parkinson's disease.
Role of Matrix Metalloproteinase-3 in Neurodegeneration.
Neuroendocrine Tumors
Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
Neurofibroma
Differences in proliferation and invasion by normal, transformed and NF1 Schwann cell cultures are influenced by matrix metalloproteinase expression.
Neurofibroma, Plexiform
Differences in proliferation and invasion by normal, transformed and NF1 Schwann cell cultures are influenced by matrix metalloproteinase expression.
Neuroinflammatory Diseases
Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation.
Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia.
Hemorrhagic transformation after ischemic stroke in animals and humans.
Matrix metalloproteinases as therapeutic targets for stroke.
Matrix Metalloproteinases, New Insights into the Understanding of Neurodegenerative Disorders.
MMP-3 contributes to nigrostriatal dopaminergic neuronal loss, BBB damage, and neuroinflammation in an MPTP mouse model of Parkinson's disease.
MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment.
Papaverine inhibits ?-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease.
Stromelysin-1 and gelatinase A are upregulated before TNF-alpha in LPS-stimulated neuroinflammation.
The Role of Matrix Metalloproteinase 3 and 9 in the Pathogenesis of Acute Neuroinflammation. Implications for Disease Modifying Therapy.
Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury.
neutrophil collagenase deficiency
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response.
Non-ST Elevated Myocardial Infarction
Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development.
Obesity
Distinct effects of calorie restriction on adipose tissue cytokine and angiogenesis profiles in obese and lean mice.
Effect of high fat diet and excessive compressive mechanical force on pathologic changes of temporomandibular joint.
Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation.
Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population.
Obstetric Labor, Premature
Imbalances between matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in maternal serum during preterm labor.
Matrix metalloproteinase 3 in parturition, premature rupture of the membranes, and microbial invasion of the amniotic cavity.
Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases -1, -2 in placentas from preterm pregnancies and their association with one carbon metabolites.
Odontogenic Cysts
Effects of positive pressure in odontogenic keratocysts.
Oral Submucous Fibrosis
Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions.
The functional (-1171 5A-->6A) polymorphisms of matrix metalloproteinase 3 gene as a risk factor for oral submucous fibrosis among male areca users.
Osteoarthritis
A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 3 (stromelysin-1) using monoclonal antibodies.
A Preliminary Study of Combined Detection of COMP, TIMP-1, and MMP-3 in Synovial Fluid: Potential Indicators of Osteoarthritis Progression.
Activation of cartilage stromelysin-1 at acid pH and its relation to enzyme pH optimum and osteoarthritis.
Alteration of matrix metalloproteinase-3 O-glycan structure as a biomarker for disease activity of rheumatoid arthritis.
AMD3100 Attenuates Matrix Metalloprotease-3 and -9 Expressions and Prevents Cartilage Degradation in a Monosodium Iodo-Acetate-Induced Rat Model of Temporomandibular Osteoarthritis.
Anti-inflammatory and anti-osteoarthritis effects of tectorigenin.
Antiosteoarthritic effect of Punica granatum L. peel extract on collagenase induced osteoarthritis rat by modulation of COL-2, MMP-3, and COX-2 expression.
Argatroban more effectively inhibits the thrombin activity in synovial fluid than naturally occurring thrombin inhibitors.
Association of MMP-3 (-1612 5A/6A) polymorphism with knee osteoarthritis in Thai population.
Cartilage oligomeric matrix protein and matrix metalloproteinase-3 expression in the serum and joint fluid of a reversible osteoarthritis rabbit model.
CD11c+ macrophages and levels of TNF-? and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidemia.
Characterization of neopeptides in equine articular cartilage degradation.
Clinical trials of a stromelysin inhibitor. Osteoarthritis, matrix metalloproteinase inhibition, cartilage loss, surrogate markers, and clinical implications.
Cloning of collagenase 3 from the synovial membrane and its expression in rheumatoid arthritis and osteoarthritis.
Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis. An immunohistochemical study.
Correction: MMP-3 gene polymorphisms are associated with increased risk of osteoarthritis in Chinese men.
Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3.
Curcumin Inhibits Proliferation of Synovial Cells by Downregulating Expression of Matrix Metalloproteinase-3 in Osteoarthritis.
CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-?B signaling pathway in osteoarthritis synovial fibroblasts.
Detection of stromelysin in synovial fluid and serum from patients with rheumatoid arthritis and osteoarthritis.
Differential in vivo expression of collagenase messenger RNA in synovium and cartilage. Quantitative comparison with stromelysin messenger RNA levels in human rheumatoid arthritis and osteoarthritis patients and in two animal models of acute inflammatory arthritis.
Distinct expression pattern of early- and late-response genes in normal and osteoarthritic human synovial membranes.
Effect of estrogen on the expression of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 and tissue inhibitor of metalloproternase-1 in osteoarthritis chondrocytes.
Effect of nimesulide on the serum levels of hyaluronan and stromelysin-1 in patients with osteoarthritis: a pilot study.
Effects of an aqueous extract of Eucommia on articular cartilage in a rat model of osteoarthritis of the knee.
Effects of celecoxib on human chondrocytes--enhanced production of chemokines.
Effects of Vitamin D Supplementation during the Induction and Progression of Osteoarthritis in a Rat Model.
Elevated levels of synovial fluid PLA2, stromelysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs.
Elevated metalloproteinase and tissue inhibitor of metalloproteinase mRNA in human osteoarthritic synovia.
Elevated plasma stromelysin levels in arthritis.
Etanercept therapy leads to reductions in matrix metalloproteinase-3 in patients with erosive hand osteoarthritis.
Evaluation of serum MMP-2 and MMP-3, synovial fluid IL-8, MCP-1, and KC concentrations as biomarkers of stifle osteoarthritis associated with naturally occurring cranial cruciate ligament rupture in dogs.
Explore the variation of MMP3, JNK, p38 MAPKs, and autophagy at the early stage of osteoarthritis.
Expression and significance of MMP3 in synovium of knee joint at different stage in osteoarthritis patients.
Expression level of proteoglycan, collagen and type II collagen in osteoarthritis rat model is promoted and degradation of cartilage is prevented by glucosamine methyl ester.
Expression of stromelysin and urokinase type plasminogen activator protein in resection specimens and biopsies at different stages of osteoarthritis of the knee.
Ferulic acid suppresses interleukin-1?-induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC-1? signaling pathway.
Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.
Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes.
Higher levels of matrix metalloproteinase-3 in patients with RA reflect disease activity and structural damage.
Histamine stimulates matrix metalloproteinase-3 and -13 production by human articular chondrocytes in vitro.
Histone Methylation and STAT-3 Differentially Regulate Interleukin-6-Induced Matrix Metalloproteinase Gene Activation in Rheumatoid Arthritis Synovial Fibroblasts.
Identification of new autolytic sites of recombinant truncated mature human fibroblast stromelysin by mass spectrometry.
Identification of the metalloproteinase stromelysin in the physis.
Immunofluorescence quantitation of stromelysin in human synovial fibroblasts by confocal laser scanning microscopy.
In situ hybridization of stromelysin mRNA in the synovial biopsies from rheumatoid arthritis.
In vitro suppression of the MMP-3 gene in normal and cytokine-treated human chondrosarcoma using small interfering RNA.
Increased level of heme oxygenase-1 in rheumatoid arthritis synovial fluid.
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
Increased secretion and activity of matrix metalloproteinase-3 in synovial tissues and chondrocytes from experimental osteoarthritis.
Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3- and 7D4) and collagen damage in cyclically load-injured articular cartilage.
Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis.
Influence of development and joint pathology on stromelysin enzyme activity in equine synovial fluid.
Inhibitory Effects of IL-6-Mediated Matrix Metalloproteinase-3 and -13 by Achyranthes japonica Nakai Root in Osteoarthritis and Rheumatoid Arthritis Mice Models.
Interferon regulatory factor 5 (IRF5) regulates the expression of matrix metalloproteinase-3 (MMP-3) in human chondrocytes.
Interleukin 1 beta and stromelysin (MMP3) activity of synovial fluid as possible markers of osteoarthritis in the temporomandibular joint.
Interleukin-1beta induced activation of nuclear factor-kappab can be inhibited by novel pharmacological agents in osteoarthritis.
Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis.
Lectin-like oxidized LDL receptor-1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
Levels of rheumatoid factor isotypes, metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in synovial fluid from various arthritides.
LncRNA-CIR promotes articular cartilage degeneration in osteoarthritis by regulating autophagy.
Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs.
Low prevalence of knee chondrocalcinosis and its catabolic association by use of serum matrix metalloproteinase 3: A rural Japanese population study.
Macrophage migration inhibitory factor up-regulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis.
Matrix metalloprotease-3 expression in the medial plica and pannus-like tissue in knees from patients with medial compartment osteoarthritis.
Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell Differentiation.
Matrix metalloproteinases MMP-3 and MMP-1 levels in sera and synovial fluids in patients with rheumatoid arthritis and osteoarthritis.
Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3.
Mechanism of basic calcium phosphate crystal-stimulated matrix metalloproteinase-13 expression by osteoarthritic synovial fibroblasts: inhibition by prostaglandin E2.
Metalloprotease activity, phospholipase A2 activity and cytokine concentration in osteoarthritis synovial fluids.
Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis.
MT3-MMP (MMP-16) is downregulated by in vitro cytokine stimulation of cartilage, but unaltered in naturally occurring equine osteoarthritis and osteochondrosis.
Naringenin regulates production of matrix metalloproteinases in the knee-joint and primary cultured articular chondrocytes and alleviates pain in rat osteoarthritis model.
Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis.
Potent collagenase inhibitors prevent interleukin-1-induced cartilage degradation in vitro.
Proline-Serine-Threonine Phosphatase-Interacting Protein 2 Alleviates Diabetes Mellitus-Osteoarthritis in Rats through Attenuating Synovial Inflammation and Cartilage Injury.
Radiological and biochemical effects (CTX-II, MMP-3, 8, and 13) of low-level laser therapy (LLLT) in chronic osteoarthritis in Al-Kharj, Saudi Arabia.
Regulatory effect of anti-gp130 functional mAb on IL-6 mediated RANKL and Wnt5a expression through JAK-STAT3 signaling pathway in FLS.
Relationships of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover and inflammation as revealed by analyses of synovial fluids from patients with rheumatoid arthritis.
Resistin as a factor in osteoarthritis: synovial fluid resistin concentrations correlate positively with interleukin 6 and matrix metalloproteinases MMP-1 and MMP-3.
ROCK inhibition enhances aggrecan deposition and suppresses matrix metalloproteinase-3 production in human articular chondrocytes.
Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors.
Serum levels of collagenase, stromelysin-1, and TIMP-1. Age- and sex-related differences in normal subjects and relationship to the extent of joint involvement and serum levels of antigenic keratan sulfate in patients with osteoarthritis.
Serum levels of matrix metalloproteinase 3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis.
Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study.
Serum levels of matrix metalloproteinase-3 in relation to the development of radiological damage in patients with early rheumatoid arthritis.
Serum matrix metalloproteinase-3 as a noninvasive biomarker of histological synovitis for diagnosis of rheumatoid arthritis.
Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor.
Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.
Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction.
Sustained and distinctive patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from inflammatory synovitis.
Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not.
Synovial fluid RANKL and matrix metalloproteinase levels in enthesitis related arthritis subtype of juvenile idiopathic arthritis.
Synovial proinflammatory cytokines and their correlation with matrix metalloproteinase-3 expression in Behçet's disease. Does interleukin-1beta play a major role in Behçet's synovitis?
Synovial TGF-?1 and MMP-3 levels and their correlation with the progression of temporomandibular joint osteoarthritis combined with disc displacement: A preliminary study.
The effect of drugs used in the treatment of osteoarthrosis on stromelysin (proteoglycanase) of equine synovial cell origin.
The effect of non-steroidal anti-inflammatory drugs on matrix metalloproteinases levels in patients with osteoarthritis.
The effects of doxycycline on nitric oxide and stromelysin production in dogs with cranial cruciate ligament rupture.
The effects of hyaluronan on matrix metalloproteinase-3 (MMP-3), interleukin-1beta(IL-1beta), and tissue inhibitor of metalloproteinase-1 (TIMP-1) gene expression during the development of osteoarthritis.
The in vivo effects of intraarticular corticosteroid injections on cartilage lesions, stromelysin, interleukin-1, and oncogene protein synthesis in experimental osteoarthritis.
The involvement of matrix metalloproteinases and inflammation in lumbar disc herniation.
The proteoglycanase from human cartilage and cultured rabbit chondrocytes and its relation to osteoarthritis.
Transin/stromelysin expression in rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes.
Tumor necrosis factor-alpha (TNF-alpha) in canine osteoarthritis: Immunolocalization of TNF-alpha, stromelysin and TNF receptors in canine osteoarthritic cartilage.
[A study of serum cartilage oligomeric matrixprotein and matrix metalloproteinase-3 concentration in osteoarthritic rabbit models].
[Biochemical analysis of the synovial fluid of the shoulder joint in patients with and without rotator cuff tears]
[Cytokines, prostaglandin E2, phospholipase A and metalloproteases in synovial fluid in osteoarthritis]
[Effect of Gancao Fuzi Decoction on osteoarthritis and proteomics of articular cartilage in rats].
[Effect of various intervention factors on MMP-3 and TIMP-1 level in synovial fluid in knee joints with osteroarthritis.]
[Levels of matrix metalloproteinase-3 and urokinase-type plasminogen activator in knee synovial fluids from patients with rheumatoid arthritis and osteoarthritis]
[Matrix metalloproteinase (MMP)-3 is not effective for evaluating hemophilic arthropathy].
[Stromelysin-1 (MMP-3) level in the sera from patients with rheumatoid arthritis and other connective tissue diseases--clinical significances in early onset rheumatoid arthritis]
Osteoarthritis, Hip
Catirlage oligomeric matrix protein, C-terminal cross-linking telopeptide of type II collagen, and matrix metalloproteinase-3 as biomarkers for knee and hip osteoarthritis (OA) diagnosis: a systematic review and meta-analysis.
[Effects of naproxen (naprosyne) on the metabolism of arthrotic cartilage in man in vivo]
Osteoarthritis, Knee
Association of MMP-3 (-1612 5A/6A) polymorphism with knee osteoarthritis in Thai population.
Cartilage oligomeric protein, matrix metalloproteinase-3, and Coll2-1 as serum biomarkers in knee osteoarthritis: a cross-sectional study.
Effects of exercise therapy on knee joint function and synovial fluid cytokine levels in patients with knee osteoarthritis.
Expression of stromelysin and urokinase type plasminogen activator protein in resection specimens and biopsies at different stages of osteoarthritis of the knee.
Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.
Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages.
Inhalation therapy of calcitonin relieves osteoarthritis of the knee.
Matrix metalloprotease-3 expression in the medial plica and pannus-like tissue in knees from patients with medial compartment osteoarthritis.
Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3.
MMP-3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy.
Serum levels of matrix metalloproteinase-3 as a prognostic marker for progression of cartilage injury in patients with knee osteoarthritis.
Use of the plasma stromelysin (matrix metalloproteinase 3) concentration to predict joint space narrowing in knee osteoarthritis.
[Effect of acupoint heat-sensitive moxibustion intervention on serum osteopontin and matrix metalloproteinase-3 in patients with acute knee pain].
[Effect of Warm-needle-moxibustion on Behavior Reactions and TNF-? and MMP-3 Contents in Knee Cartilage of Rabbits with Knee Osteoarthritis].
Osteochondrosis
Influence of development and joint pathology on stromelysin enzyme activity in equine synovial fluid.
Osteolysis
Histologic and biochemical differences between osteolytic and nonosteolytic membranes around femoral components of an uncemented total hip arthroplasty.
Mycoplasma bovis induces matrix metalloproteinase-3 expression in bovine synovial cells via up-regulation of interleukin-1? expression in mononuclear cells.
Osteonecrosis
MMP-3 and MMP-8 single-nucleotide polymorphisms are related to alcohol-induced osteonecrosis of the femoral head in Chinese males.
Osteophyte
The localization of matrix metalloproteinase-3 and tenascin in synovial membrane of the temporomandibular joint with internal derangement.
[Experimental study on replicating knee osteoarthritis by modified Hulth's modeling method]
Osteoporosis
Associations of Changes in Serum Inflammatory Factors, MMP-3, 25(OH)D and Intestinal Flora with Osteoporosis and Disease Activity in Rheumatoid Arthritis Patients.
Connective tissue metabolism in patients with unclassified polyarthritis and early rheumatoid arthritis. Relationship to disease activity, bone mineral density, and radiographic outcome.
Detection of stromelysin in synovial fluid and serum from patients with rheumatoid arthritis and osteoarthritis.
Identification of human serum protein targets of Qianggu Decoction () in primary type I osteoporosis based on tandem mass tag labeling and liquid chromatography-tandem mass spectrometry technology.
Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study.
Stromelysin (MMP-3) synthesis is up-regulated in estrogen-deficient mouse osteoblasts in vivo and in vitro.
Osteosarcoma
Discordant effects of activator protein-1 transcription factor on gene regulation, invasion, and metastasis in spontaneous, radiation-induced, and fos-induced osteosarcomas.
Elevated expression of matrix metalloproteinase-3 in human osteosarcoma and its association with tumor metastasis.
Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis.
Expression of the transin, c-fos, and c-jun genes in rat transplantable osteosarcomas and malignant fibrous histiocytomas.
Glucosamine sulfate suppresses the expression of matrix metalloproteinase-3 in osteosarcoma cells in vitro.
MMP-3 gene polymorphisms and Osteosarcoma.
Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha.
Zinc-binding protein-89 (ZBP-89) cooperates with NF-?B to regulate expression of matrix metalloproteinases (MMPs) in response to inflammatory cytokines.
Otosclerosis
Aberration of the tissue collagenase system in association with otosclerosis.
Evidence of abnormal stromelysin mRNA expression in suspected carriers of otosclerosis. A possible molecular marker.
Ovarian Neoplasms
Matrix metalloproteinase 3 is a stromal marker for chicken ovarian cancer.
MicroRNA-18a-5p Suppresses Tumor Growth via Targeting Matrix Metalloproteinase-3 in Cisplatin-Resistant Ovarian Cancer.
Molecular regulation of ovarian cancer cell invasion.
Optical imaging of ovarian cancer using a matrix metalloproteinase-3-sensitive near-infrared fluorescent probe.
PCR analysis of matrix metalloproteinase 3 (MMP-3) gene promoter polymorphism in ovarian cancer.
Polymorphisms in the promoter regions of the matrix metalloproteinases-1, -3, -7, and -9 and the risk of epithelial ovarian cancer in China.
Small integrin binding ligand N-linked glycoprotein gene family expression in different cancers.
The promoter polymorphism of the matrix metalloproteinase 3 (MMP-3) gene in women with ovarian cancer.
[Association of single nucleotide polymorphism in matrix metalloproteinases promoter with susceptibility to ovarian cancer]
Pancreatic Neoplasms
Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer.
Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
HOXA10 Promotes Cell Invasion and MMP-3 Expression Via TGF?2-Mediated Activation of the p38 MAPK Pathway in Pancreatic Cancer Cells.
RNA interference suppression of mucin 5AC (MUC5AC) reduces the adhesive and invasive capacity of human pancreatic cancer cells.
Pancreatitis
The influence of transforming growth factor beta 1 on the expression of genes coding for matrix metalloproteinases and tissue inhibitors of metalloproteinases during regeneration from cerulein-induced pancreatitis.
Pancreatitis, Chronic
Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitis.
Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
Plasma TGF-?1, MMP-1 and MMP-3 Levels in Chronic Pancreatitis.
Role of matrix metalloproteinase 3 gene promoter polymorphism in chronic pancreatitis.
Papilloma
Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression.
The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.
Transcriptional modulation of transin gene expression by epidermal growth factor and transforming growth factor beta.
v-jun oncogene suppresses both phorbol ester-induced cell invasion and stromelysin gene expression in a mouse papilloma cell line.
Paraneoplastic Syndromes
Remitting seronegative symmetrical synovitis with pitting edema syndrome complicated with primary lung cancer.
Parkinson Disease
A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinson's disease induced by MPTP.
Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease.
Matrix metalloproteinase-3 in the central nervous system: a look on the bright side.
Matrix metalloproteinase-3 is activated by HtrA2/Omi in dopaminergic cells: Relevance to Parkinson's disease.
Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia.
MMP-3 contributes to nigrostriatal dopaminergic neuronal loss, BBB damage, and neuroinflammation in an MPTP mouse model of Parkinson's disease.
Multifunctional Nanoprobe for the Delivery of Therapeutic siRNA and Real-Time Molecular Imaging of Parkinson's Disease Biomarkers.
Papaverine inhibits ?-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease.
Role of Matrix Metalloproteinase-3 in Neurodegeneration.
Pemphigoid, Bullous
Profibrotic phenotype of conjunctival fibroblasts from mucous membrane pemphigoid.
Peptic Ulcer
Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers.
[Role of Allelic Genes of Matrix Metalloproteinases and Their Tissue Inhibitors in the Peptic Ulcer Disease Development].
Periapical Periodontitis
The Expression of Semaphorin 7A in Human Periapical Lesions.
Perinatal Death
Stromelysin-1 (MMP-3) expression driven by a macrophage-specific promoter results in reduced viability in transgenic mice.
Periodontal Diseases
Advances in understanding cell interactions in tissue resorption. Relevance to the pathogenesis of periodontal diseases and a new hypothesis.
Circulating matrix metalloproteinase-8 (MMP-8) and MMP-9 are increased in chronic periodontal disease and decrease after non-surgical periodontal therapy.
Cytokine and metalloproteinases in gingival fluid from patients with chronic periodontitis.
Effects of interleukin-1 beta on matrix metalloproteinase-3 levels in human periodontal ligament cells.
Estimation of matrix metalloproteinase-3 levels in gingival crevicular fluid in periodontal disease, health and after scaling and root planing.
Evaluation of gingival crevicular fluid levels of tissue plasminogen activator, plasminogen activator inhibitor 2, matrix metalloproteinase-3 and interleukin 1-? in patients with different periodontal diseases.
Immunolocalization of matrix metalloproteinases and TIMP-1 (tissue inhibitor of metalloproteinases) in human gingival tissues from periodontitis patients.
Infliximab Induced a Dissociated Response of Severe Periodontal Biomarkers in Rheumatoid Arthritis Patients.
Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis.
Prostaglandin E2 regulates interleukin-1beta-induced matrix metalloproteinase-3 production in human gingival fibroblasts.
[Effects of baicalin on the expression of pro-MMP-1 and MMP-3 in human gingival fibroblasts and periodontal ligament cells]
Periodontitis
Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue.
Association of Common Variants in MMPs with Periodontitis Risk.
Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis.
Comparison of matrix metalloproteinase-3 and tissue inhibitor of matrix metalloproteinase-1 levels in gingival crevicular fluid in periodontal health, disease and after treatment: A clinico biochemical study.
Danzhi Jiangtang capsule alleviate hyperglycemia and periodontitis via Wnt/?-catenin signaling in diabetic rat.
EVALUATION OF BONE RESORPTIVE POTENTIAL IN THE TREATMENT OF GENERALIZED PERIODONTITIS.
Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants.
Genetic polymorphisms in the MMP-1 and MMP-3 gene may contribute to chronic periodontitis in a Brazilian population.
Gingival crevicular stromelysin, collagenase and tissue inhibitor of metalloproteinases levels in healthy and diseased sites.
Gingival Tissue and Crevicular Fluid Co-operation in Adult Periodontitis.
Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3).
Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva.
Interleukin-4 suppresses IL-1-induced expression of matrix metalloproteinase-3 in human gingival fibroblasts.
Longitudinal evaluation of GCF MMP-3 and TIMP-1 levels as prognostic factors for progression of periodontitis.
Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis.
Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis.
Mechanistic features associated with induction of metalloproteinases in human gingival fibroblasts by interleukin-1.
MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis.
Pathogen profile and MMP-3 levels in areas with varied attachment loss in generalized aggressive and chronic periodontitis.
Prostaglandin E2 regulates interleukin-1beta-induced matrix metalloproteinase-3 production in human gingival fibroblasts.
[Expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model]
Pheochromocytoma
A novel nerve growth factor-responsive element in the stromelysin-1 (transin) gene that is necessary and sufficient for gene expression in PC12 cells.
The metalloproteinase stromelysin-1 (transin) mediates PC12 cell growth cone invasiveness through basal laminae.
Phlebitis
Stromelysin-1 5A/6A and eNOS T-786C Polymorphisms, MTHFR C677T and A1298C Mutations, and Cigarette-Cannabis Smoking: A Pilot, Hypothesis-Generating Study of Gene-Environment Pathophysiological Associations With Buerger's Disease.
Pleural Effusion
Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma.
Occurrence of matrix metalloproteinases and tissue inhibitors of metalloproteinases in tuberculous pleuritis.
Pleural fluid analysis of lung cancer vs benign inflammatory disease patients.
[Matrix metalloproteinases and their inhibitors in lung cancer with malignant pleural effusion]
Pleural Effusion, Malignant
Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma.
Pleurisy
Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma.
Occurrence of matrix metalloproteinases and tissue inhibitors of metalloproteinases in tuberculous pleuritis.
Pneumonia
Lack of matrix metalloproteinase 3 in mouse models of lung injury ameliorates the pulmonary inflammatory response in female but not in male mice.
Polycythemia Vera
Importance of plasma matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinase (TIMP) in development of fibrosis in agnogenic myeloid metaplasia.
Polymyalgia Rheumatica
Analysis of the relationship between polymyalgia rheumatica and matrix metalloproteinase-3 levels during the first medical examination and during treatment.
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
Polymyositis
Expression of matrix metalloproteinases in the muscle of patients with inflammatory myopathies.
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Matrix metalloproteinase upregulation in chronic inflammatory demyelinating polyneuropathy and nonsystemic vasculitic neuropathy.
Porphyria Cutanea Tarda
Photosensitization of uroporphyrin augments the ultraviolet A-induced synthesis of matrix metalloproteinases in human dermal fibroblasts.
Porphyrias
Photosensitization of uroporphyrin augments the ultraviolet A-induced synthesis of matrix metalloproteinases in human dermal fibroblasts.
Pre-Eclampsia
Altered Maternal Serum Matrix Metalloproteinases MMP-2, MMP-3, MMP-9, and MMP-13 in Severe Early- and Late-Onset Preeclampsia.
Expression, regulation and functional characterization of matrix metalloproteinase-3 of human trophoblast.
Matrix metalloproteinase multiplex screening identifies increased MMP-2 urine concentrations in women predicted to develop preeclampsia.
Precancerous Conditions
Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis.
Pregnancy, Tubal
Differential Expression of EGFR-1, MMP-3, and MMP-9 in Spontaneous Abortions, Induced Abortions, and Tubal Pregnancies.
Pressure Ulcer
Analysis of Gene Expression in Experimental Pressure Ulcers in the Rat with Special Reference to Inflammatory Cytokines.
Primary Myelofibrosis
Importance of plasma matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinase (TIMP) in development of fibrosis in agnogenic myeloid metaplasia.
Progeria
Age-Dependent Loss of MMP-3 in Hutchinson-Gilford Progeria Syndrome.
Prostatic Neoplasms
Aquaporin 3 promotes prostate cancer cell motility and invasion via extracellular signal-regulated kinase 1/2-mediated matrix metalloproteinase-3 secretion.
Assessment of 54 biomarkers for biopsy-detectable prostate cancer.
Eotaxin-1 promotes prostate cancer cell invasion via activation of the CCR3-ERK pathway and upregulation of MMP-3 expression.
Estrogen receptor ? in cancer-associated fibroblasts suppresses prostate cancer invasion via modulation of thrombospondin 2 and matrix metalloproteinase 3.
Expression and functional role of CCR9 in prostate cancer cell migration and invasion.
Green tea-induced epigenetic reactivation of tissue inhibitor of matrix metalloproteinase-3 suppresses prostate cancer progression through histone-modifying enzymes.
IL-7/IL-7 receptor axis stimulates prostate cancer cell invasion and migration via AKT/NF-?B pathway.
Impact of MMP-3 and TIMP-3 gene polymorphisms on prostate cancer susceptibility in North Indian cohort.
Inhibition of tumor growth and induction of apoptosis in prostate cancer cell lines by overexpression of tissue inhibitor of matrix metalloproteinase-3.
Platelet-activating factor receptor activation promotes prostate cancer cell growth, invasion and metastasis via ERK1/2 pathway.
Prostate cancer-derived MMP-3 controls intrinsic cell growth and extrinsic angiogenesis.
Reactive oxygen species-mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression.
Proteinuria
Effect of a specific endothelin receptor A antagonist and an angiotensin-converting enzyme inhibitor on glomerular mRNA levels for extracellular matrix components, metalloproteinases (MMP) and a tissue inhibitor of MMP in aminonucleoside nephrosis.
Increased levels of matrix metalloproteinase-3 in sera from patients with active lupus nephritis.
Matrix metalloproteinase (stromelysin-1) increases the albumin permeability of isolated rat glomeruli.
[The effect of tripterine in prevention of glomerulosclerosis in lupus nephritis mice]
Pseudoxanthoma Elasticum
Cysteine protease characteristics of the proteoglycanase activity from normal and pseudoxanthoma elasticum (PXE) fibroblasts.
Dermal fibroblasts from pseudoxanthoma elasticum patients have raised MMP-2 degradative potential.
Psoriasis
Analysis of clinical, radiological and laboratory variables in psoriatic arthritis with 25 Japanese patients.
Efficacy of methotrexate and tumor necrosis factor inhibitors in Japanese patients with active psoriatic arthritis.
Expression of microRNA-21 and TIMP-3 in paradoxical psoriasiform reactions during treatment with antitumor necrosis factor agents.
Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients.
ROC analysis of selected matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in psoriatic patients.
Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study.
Serum soluble bone turnover biomarkers in psoriatic arthritis and psoriatic spondyloarthropathy.
Soluble biomarkers differentiate patients with psoriatic arthritis from those with psoriasis without arthritis.
Soluble biomarkers may differentiate psoriasis from psoriatic arthritis.
Ultrasound assessment, unlike clinical assessment, reflects enthesitis in patients with psoriatic arthritis.
Update on biomarkers in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting.
Pterygium
Cyclosporine A Downregulates MMP-3 and MMP-13 Expression in Cultured Pterygium Fibroblasts.
Inhibition of Pterygium Fibroblast Migration and Outgrowth by Bevacizumab and Cyclosporine A Involves Down-Regulation of Matrix Metalloproteinases-3 and -13.
Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium.
Overexpression of collagenase (MMP-1) and stromelysin (MMP-3) by pterygium head fibroblasts.
Regulation of collagenase, stromelysin, and urokinase-type plasminogen activator in primary pterygium body fibroblasts by inflammatory cytokines.
The Nuclear-Factor Kappa B Pathway is Activated in Pterygium.
Pulmonary Disease, Chronic Obstructive
Carcinogenesis-related changes in iron metabolism in chronic obstructive pulmonary disease subjects with lung cancer.
Concomitant elevations of MMP-9, NGAL, proMMP-9/NGAL and neutrophil elastase in serum of smokers with chronic obstructive pulmonary disease.
Induced sputum metalloproteinases and their inhibitors in relation to exhaled nitrogen oxide and sputum nitric oxides and other inflammatory cytokines in patients with chronic obstructive pulmonary disease.
Matrix metalloproteinase 3 polymorphisms as a potential marker of enhanced susceptibility to lung cancer in chronic obstructive pulmonary disease subjects.
Matrix metalloproteinase gene polymorphisms: lack of association with chronic obstructive pulmonary disease in a Brazilian population.
MMP-3 (-1171 5A/6A; Lys45Glu) variants affect serum levels of matrix metalloproteinase (MMP)-3 and correlate with severity of COPD: A study of MMP-3, MMP-7 and MMP-12 in a Tunisian population.
MMP-9 genetic polymorphism may confer susceptibility to COPD.
Stromelysin-1 polymorphism as a new potential risk factor in progression of chronic obstructive pulmonary disease.
The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings.
Pulmonary Edema
Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells.
Pulmonary Fibrosis
Matrix Metalloproteinase 3 Is a Mediator of Pulmonary Fibrosis.
Protein Tyrosine Phosphatase ? Mediates Profibrotic Signaling in Lung Fibroblasts through TGF-? Responsiveness.
The importance of matrix metalloproteinase-3 in respiratory disorders.
Pulpitis
Cholinoceptor modulation on nitric oxide regulates prostaglandin E(2) and metalloproteinase-3 production in experimentally induced inflammation of rat dental pulp.
Down-regulation of inflammatory mediator synthesis and infiltration of inflammatory cells by MMP-3 in experimentally induced rat pulpitis.
The anti-inflammatory effects of matrix metalloproteinase-3 on irreversible pulpitis of mature erupted teeth.
Tissue levels of matrix metalloproteinases in pulps and periapical lesions.
Radiculopathy
Chemokine profile of disc degeneration with acute or chronic pain.
Refractive Errors
Assessment of the association of matrix metalloproteinases with myopia, refractive error and ocular biometric measures in an Australian cohort.
Myopia and polymorphisms in genes for matrix metalloproteinases.
Renal Insufficiency
The significance of metalloproteinase 3 (MMP-3), chemokine CXC ligand 13 (CXCL-13) and complement component C5a in different stages of ANCA associated vasculitis.
Reperfusion Injury
Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures.
Retinal Detachment
Predominance of MMP-1 and MMP-2 in epiretinal and subretinal membranes of proliferative vitreoretinopathy.
Retinoblastoma
HOXB5 promotes retinoblastoma cell migration and invasion via ERK1/2 pathway-mediated MMPs production.
Rheumatic Diseases
Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers.
Diagnostic utility of anti-cyclic citrullinated peptide antibodies for very early rheumatoid arthritis.
Increased levels of matrix metalloproteinase-3 in sera from patients with active lupus nephritis.
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
Influence of Matrix metalloproteinase 1 and 3 genetic variations on susceptibility and severity of juvenile idiopathic arthritis.
Prolonged matrix metalloproteinase-3 high expression after cyclic compressive load on human synovial cells in three-dimensional cultured tissue.
Using inhibitors of metalloproteinases to treat arthritis. Easier said than done?
Rheumatic Fever
Serum matrix metalloproteinase-3 in hemodialysis patients with dialysis-related amyloidosis.
Rheumatic Heart Disease
Myocardial matrix metalloproteinase-3 and matrix metalloproteinase inhibitor-1 expression in congestive heart failure.
Rheumatoid Nodule
Matrix metalloproteinase gene polymorphisms in patients with rheumatoid arthritis.
MMP expression in rheumatoid inflammation: the rs11568818 polymorphism is associated with MMP-7 expression at an extra-articular site.
Rosacea
Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant.
Sacroiliitis
Analysis of clinical, radiological and laboratory variables in psoriatic arthritis with 25 Japanese patients.
Interleukin 6 is not a crucial regulator in an animal model of tumour necrosis factor-mediated bilateral sacroiliitis.
Pannus inflammation in sacroiliitis following immune pathological injury and radiological structural damage: a study of 193 patients with spondyloarthritis.
Role of matrix metalloproteinase-3 (MMP-3) and magnetic resonance imaging of sacroiliitis in assessing disease activity in ankylosing spondylitis.
Sarcoidosis
Matrix metalloproteinases and their tissue inhibitors in the lesions of cardiac and pulmonary sarcoidosis: an immunohistochemical study.
Sarcoma
Expression of metalloproteinases endometrial stromal sarcoma: immunohistochemical study using image analysis.
Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.
Tumor induced by Moloney sarcoma virus causes periosteal osteogenesis engaging osteopontin, fibronectin, stromelysin-1 and tenascin.
Sarcoma, Avian
Gene transfer of metalloproteinase transin induces aberrant behavior of cultured mesangial cells.
Purification and properties of extracellular matrix-degrading metallo-proteinase overproduced by Rous sarcoma virus-transformed rat liver cell line, and its identification as transin.
Sarcoma, Endometrial Stromal
Expression of metalloproteinases endometrial stromal sarcoma: immunohistochemical study using image analysis.
Sarcoma, Synovial
Essential role of mitogen-activated protein kinases in IL-17A-induced MMP-3 expression in human synovial sarcoma cells.
Sarcopenia
Matrix metalloprotease 3 is associated with sarcopenia in rheumatoid arthritis - results from the CHIKARA study.
Scleritis
Increased expression of matrix metalloproteinases in vivo in scleritis tissue and in vitro in cultured human scleral fibroblasts.
Stromelysin (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase (TIMP-1) mRNA expression in scleritis.
Scleroderma, Diffuse
[Stromelysin-1 (MMP-3) level in the sera from patients with rheumatoid arthritis and other connective tissue diseases--clinical significances in early onset rheumatoid arthritis]
Scleroderma, Localized
Keratinocyte-derived cytokines after photodynamic therapy and their paracrine induction of matrix metalloproteinases in fibroblasts.
Scleroderma, Systemic
Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis.
Gene expression of types I and III collagen, decorin, matrix metalloproteinases and tissue inhibitors of metalloproteinases in skin fibroblasts from patients with systemic sclerosis.
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta.
Serum matrix metalloproteinase-3 in systemic sclerosis.
Stromelysin promoter polymorphism is associated with systemic sclerosis.
Scoliosis
Association Between IL-6 and MMP-3 Common Genetic Polymorphisms and Idiopathic Scoliosis in Bulgarian Patients: A Case-Control Study.
Association between IL-6 and MMP-3 gene polymorphisms and adolescent idiopathic scoliosis: a case-control study.
Association of IL-6 and MMP-3 gene polymorphisms with susceptibility to adolescent idiopathic scoliosis: a meta-analysis.
Lack of Association Between the Promoter Polymorphisms of MMP-3 and IL-6 Genes and Adolescent Idiopathic Scoliosis: A Case-Control Study in a Chinese Han Population.
Polymorphisms in promoter regions of MMP-3 and IL-6 genes are not associated to adolescent idiopathic scoliosis (AIS) gender bias.
Sepsis
Elevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate with Organ Dysfunction and Mortality in Sepsis.
The effect of gender and genetic polymorphisms on MMPs and TIMPs plasma levels in different infectious and non-infectious conditions.
[Effects of glutamine on matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-3 expressions in myocardium of rats with sepsis]
Silicosis
[Relationship between genetic polymorphisms of matrix metalloproteinase-2 and -3 and susceptibility to silicosis].
Sjogren's Syndrome
Autoantibody and Biopsy Grading Are Associated with Expression of ICAM-1, MMP-3, and TRAIL in Salivary Gland Mononuclear Cells of Chinese Patients with Sjogren's Syndrome.
[Stromelysin-1 (MMP-3) level in the sera from patients with rheumatoid arthritis and other connective tissue diseases--clinical significances in early onset rheumatoid arthritis]
Skin Diseases
Erosive pustular dermatosis of the scalp arising concomitantly with elevation of serum matrix metalloproteinase-3 in a patient with rheumatoid arthritis.
Skin Neoplasms
Increased expression of stromelysin-3 in basal cell carcinomas.
Skin Ulcer
[Effect of Shengji Huayu Recipe on the expression of MMP-3 and TIMP-1 in skin ulcer tissue of diabetic rats].
Soft Tissue Injuries
The MMP3 gene in musculoskeletal soft tissue injury risk profiling: A study in two independent sample groups.
Spasm
Genetic risk and gene-environment interaction in coronary artery spasm in Japanese men and women.
Spinal Cord Injuries
Jmjd3 mediates blood-spinal cord barrier disruption after spinal cord injury by regulating MMP-3 and MMP-9 expressions.
Matrix metalloproteinase-3 promotes early blood-spinal cord barrier disruption and hemorrhage and impairs long-term neurological recovery after spinal cord injury.
MMP-3 secreted from endothelial cells of blood vessels after spinal cord injury activates microglia, leading to oligodendrocyte cell death.
Multi-Potent Adult Progenitor Cells, but not Tissue Inhibitor of Matrix Metalloproteinase-3, Increase Tissue Sparing and Reduce Urological Complications following Spinal Cord Injury.
Transplantation of fibroblasts that overexpress matrix metalloproteinase-3 into the site of spinal cord injury in rats.
Spinal Stenosis
The increased expression of matrix metalloproteinases associated with elastin degradation and fibrosis of the ligamentum flavum in patients with lumbar spinal stenosis.
Spondylarthritis
Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor ? inhibitors: a study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover.
Spondylarthropathies
Serum levels of matrix metalloproteinase-3 in undifferentiated spondyloarthropathy.
Spondylitis, Ankylosing
ASDAS, BASDAI and different treatment responses and their relation to biomarkers of inflammation, cartilage and bone turnover in patients with axial spondyloarthritis treated with TNF? inhibitors.
Association study between matrix metalloproteinase-3 gene (MMP3) polymorphisms and ankylosing spondylitis susceptibility.
Changes of serum levels of MMP-3, sRANKL, and OPG in juvenile-onset ankylosing spondylitis patients carrying different HLA-B27 subtypes.
Circulating Levels of Soluble Receptor Activator of NF- ? B Ligand and Matrix Metalloproteinase 3 (and Their Antagonists) in Asian Indian Patients with Ankylosing Spondylitis.
Expression of TNF-?, VEGF, and MMP-3 mRNAs in synovial tissues and their roles in fibroblast-mediated osteogenesis in ankylosing spondylitis.
Genetic polymorphisms of the matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases-1 (TIMP-1) modulate the development of ankylosing spondylitis.
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
Lack of association of matrix metalloproteinase 3 (MMP3) genotypes with ankylosing spondylitis susceptibility and severity.
Levels of serum matrix metalloproteinase-3 correlate with disease activity in the enthesitis-related arthritis category of juvenile idiopathic arthritis.
Matrix metalloproteinase expression in the spondyloarthropathies.
Role of matrix metalloproteinase-3 (MMP-3) and magnetic resonance imaging of sacroiliitis in assessing disease activity in ankylosing spondylitis.
Serum levels of matrix metalloproteinase 3 and macrophage colony-stimulating factor 1 correlate with disease activity in ankylosing spondylitis.
Serum levels of MMP-3 and cathepsin K in patients with ankylosing spondylitis: effect of TNFalpha antagonist therapy.
Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis.
Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in ankylosing spondylitis: MMP-3 is a reproducibly sensitive and specific biomarker of disease activity.
Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis.
Serum MMP-3 Level as a Biomarker for Monitoring and Predicting Response to Etanercept Treatment in Ankylosing Spondylitis.
The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases.
[Clinical study of etanercept for treating ankylosing spondylitis]
[Effects of infliximab and etanercept, two types of anti-tumor necrosis factor-alpha inhibitor on serum level of matrix metalloproteinase 3 expression in patients with ankylosing spondylitis]
[Serum metalloproteinase-3 levels in assessing efficacy of Etanercept in patients with ankylosing spondylitis].
Spondylolisthesis
Matrix metalloproteinase-3 on ligamentum flavum in degenerative lumbar spondylolisthesis.
Spondylosis
Exploration about changes of IL-10, NF-?B and MMP-3 in a rat model of cervical spondylosis.
[Effects of Chiropractics on Intervertebral Disk Extracell Matrix and Metabolic Enzymes in Rats with Cervical Spondylosis].
Squamous Cell Carcinoma of Head and Neck
Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma.
Concomitantly elevated serum matrix metalloproteinases 3 and 9 can predict survival of synchronous squamous cell carcinoma of the upper aero-digestive tract.
Cyr61 increases matrix metalloproteinase-3 expression and cell motility in human oral squamous cell carcinoma cells.
Expression of ?v?6 integrin and collagen fibre in oral squamous cell carcinoma: association with clinical outcomes and prognostic implications.
Expression of ets-1 transcription factor in human head and neck squamous cell carcinoma and effect of histamine on metastatic potential of invasive tumor through the regulation of expression of ets-1 and matrix metalloproteinase-3.
Matrix metalloproteinase 3 polymorphism: a predictive factor of response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma.
Metaanalysis of the significance of matrix metalloproteinases for lymph node disease in patients with head and neck squamous cell carcinoma.
Requirement of MMP-3 in anchorage-independent growth of oral squamous cell carcinomas.
Serum and Saliva MMP-3 in Patients with OLP and Oral SCC.
Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions.
The 2G allele of promoter region of Matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma.
Upregulation of serum vascular endothelial growth factor and matrix metalloproteinase-3 in patients with oral squamous cell carcinoma.
ST Elevation Myocardial Infarction
Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development.
Serum and Echocardiographic Markers May Synergistically Predict Adverse Cardiac Remodeling after ST-Segment Elevation Myocardial Infarction in Patients with Preserved Ejection Fraction.
Starvation
Differential regulation of collagenase and stromelysin mRNA in late passage cultures of human fibroblasts.
Forkhead factor, FOXO3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases.
Still's Disease, Adult-Onset
Elevated levels of soluble Fas (APO-1, CD95), soluble Fas ligand, and matrix metalloproteinase-3 in sera from patients with active untreated adult onset Still's disease.
Stomach Neoplasms
Elevated Serum Matrix Metalloproteinase-3 and -7 in H. pylori-Related Gastric Cancer Can Be Biomarkers Correlating with a Poor Survival.
Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance.
Heterozygosity of stromelysin-1 (rs3025058) promoter polymorphism is associated with gastric cancer.
Involvement of microRNAs-MMPs-E-cadherin in the migration and invasion of gastric cancer cells infected with Helicobacter pylori.
KITENIN is associated with tumor progression in human gastric cancer.
Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines.
Matrix metalloproteinases and their inhibitors in gastric cancer.
Silencing of the MMP-3 gene by siRNA transfection in gastric cancer AGS cells.
Stomach Ulcer
Elevated Serum Matrix Metalloproteinase-3 and -7 in H. pylori-Related Gastric Cancer Can Be Biomarkers Correlating with a Poor Survival.
Potential role for matrix metalloproteinase-3 in gastric ulcer healing.
Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing.
[Role of Allelic Genes of Matrix Metalloproteinases and Their Tissue Inhibitors in the Peptic Ulcer Disease Development].
Stomatitis
Involvement of matrix metalloproteinases (MMP-3 and MMP-9) in the pathogenesis of irinotecan-induced oral mucositis.
Stomatitis, Aphthous
Collagenase and stromelysin in recurrent aphthous ulcers (RAU).
Stroke
Activation of matrix metalloproteinase-3 and agrin cleavage in cerebral ischemia/reperfusion.
Association of blood active matrix metalloproteinase-3 with carotid plaque score from a community population in Taiwan.
Association of matrix metalloproteinase-3 gene 5A/6A polymorphism with the recurrence of ischemic stroke: A prospective observational study.
Association of tumor necrosis factor-? and matrix metalloproteinase-3 gene variants with stroke.
Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size.
Matrix metalloproteinase-3 and intracranial arterial dolichoectasia.
Matrix metalloproteinase-3 in myasthenia gravis compared to other neurological disorders and healthy controls.
Peroxynitrite-Induced Tyrosine Nitration Contributes to Matrix Metalloprotease-3 Activation: Relevance to Hyperglycemic Ischemic Brain Injury and Tissue Plasminogen Activator.
Pharmacogenetic effect of the stromelysin (MMP3) polymorphism on stroke risk in relation to antihypertensive treatment: the genetics of hypertension associated treatment study.
Plasma proteomics of patients with non-valvular atrial fibrillation on chronic anti-coagulation with warfarin or a direct factor Xa inhibitor.
Proinflammatory genetic profiles in subjects with history of ischemic stroke.
Serum levels of matrix metalloproteinases: implications in clinical neurology.
Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice.
Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein.
stromelysin 1 deficiency
Altered neuronal architecture and plasticity in the visual cortex of adult MMP-3-deficient mice.
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response.
MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment.
The effect of matrix metalloproteinase-3 deficiency on pulmonary surfactant in a mouse model of acute lung injury.
Subarachnoid Hemorrhage
Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage.
Synovitis
Alterations in Synovial Fluid Biomarker Levels in Knees With Meniscal Injury as Compared With Asymptomatic Contralateral Knees.
Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology.
Bone edema determined by magnetic resonance imaging reflects severe disease status in patients with early-stage rheumatoid arthritis.
Decline after immobilisation and recovery after remobilisation of synovial fluid IL1, TIMP, and chondroitin sulphate levels in young beagle dogs.
Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis.
Detection of synovial inflammation in rheumatic diseases using superb microvascular imaging: Comparison with conventional power Doppler imaging.
Effect of p38 Mitogen Activated Protein Kinase Inhibitor on Temporomandibular Joint Synovitis Induced by Occlusal Alteration.
Expression of metalloproteinases in pigmented villonodular synovitis.
High serum matrix metalloproteinase 3 is characteristic of patients with paraneoplastic remitting seronegative symmetrical synovitis with pitting edema syndrome.
Increased levels of proteoglycan fragments and stromelysin in hip joint fluid in Legg-Calvé-Perthes disease.
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
Influence of Matrix metalloproteinase 1 and 3 genetic variations on susceptibility and severity of juvenile idiopathic arthritis.
Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy.
Pathological features of established osteoarthritis with hydrathrosis are similar to rheumatoid arthritis.
Predictors of Cardiovascular Affection in Patients with Active Rheumatoid Arthritis: Secondary Analysis of a Randomized Controlled Trial.
Relationship between arthroscopic findings of synovitis and levels of tumour necrosis factor-alpha and matrix metalloproteinases in synovial lavage fluid from patients with unilateral high mandibular condyle fractures.
Remitting seronegative symmetrical synovitis with pitting edema syndrome complicated with primary lung cancer.
Serum levels of matrix metalloproteinase 3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis.
Serum matrix metalloproteinase 3 in detecting remitting seronegative symmetrical synovitis with pitting edema syndrome: A case report.
Serum matrix metalloproteinase-3 as a noninvasive biomarker of histological synovitis for diagnosis of rheumatoid arthritis.
Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis.
Sustained and distinctive patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from inflammatory synovitis.
Synovial proinflammatory cytokines and their correlation with matrix metalloproteinase-3 expression in Behçet's disease. Does interleukin-1beta play a major role in Behçet's synovitis?
The Relationship between Remitting Seronegative Symmetrical Synovitis with Pitting Edema and Vascular Endothelial Growth Factor and Matrix Metalloproteinase 3.
[Stromelysin-1 in inflammatory disease: significance, specificity, and regulation elements]
Synovitis, Pigmented Villonodular
Expression of metalloproteinases in pigmented villonodular synovitis.
Taste Disorders
Measurements of several metallic elements and matrix metalloproteinases (MMPs) in saliva from patients with taste disorder.
Temporomandibular Joint Disorders
MMP-3 activation is a hallmark indicating an early change in TMJ disorders, and is related to nitration.
Prolonged matrix metalloproteinase-3 high expression after cyclic compressive load on human synovial cells in three-dimensional cultured tissue.
Tendinopathy
Additional evidence supports association of common genetic variants in MMP3 and TIMP2 with increased risk of chronic Achilles tendinopathy susceptibility.
Association of the matrix metalloproteinase 3 (MMP3) single nucleotide polymorphisms with tendinopathies: case-control study in high-level athletes.
Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy.
Enhanced tendon restoration effects of anti-inflammatory, lactoferrin-immobilized, heparin-polymeric nanoparticles in an Achilles tendinitis rat model.
Multiple changes in gene expression in chronic human Achilles tendinopathy.
Photobiomodulation therapy on collagen type I and III, vascular endothelial growth factor, and metalloproteinase in experimentally induced tendinopathy in aged rats.
Trigger finger, tendinosis, and intratendinous gene expression.
Variants within the MMP3 gene are associated with Achilles tendinopathy: Possible interaction with the COL5A1 gene.
Tenosynovitis
Imbalanced MMP-3 and MMP-12 serum levels in systemic lupus erythematosus patients with Jaccoud's arthropathy and a distinctive MRI pattern.
Tetralogy of Fallot
Modulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repair.
Thromboangiitis Obliterans
Immunohistochemical properties in the patients with Buerger's disease-possible role of plasminogen activator inhibitor-1 for preservation of vessel wall architecture.
Stromelysin-1 5A/6A and eNOS T-786C Polymorphisms, MTHFR C677T and A1298C Mutations, and Cigarette-Cannabis Smoking: A Pilot, Hypothesis-Generating Study of Gene-Environment Pathophysiological Associations With Buerger's Disease.
Thrombocytosis
Importance of plasma matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinase (TIMP) in development of fibrosis in agnogenic myeloid metaplasia.
Thrombophlebitis
Matrix metalloproteinases in the vein wall.
Thrombosis
Association of -1171 promoter polymorphism of matrix metalloproteinase-3 with increased risk for oral cancer.
Expression changes and roles of matrix metalloproteinases in a rat model of traumatic deep vein thrombosis.
MMP-3-1612 polymorphism--a risk factor for deep venous thrombosis formation.
Vascular and Cardiac Impairments in Rats Inhaling Ozone and Diesel Exhaust Particles.
Thyroid Neoplasms
CCL20/CCR6 promotes the invasion and migration of thyroid cancer cells via NF-kappa B signaling-induced MMP-3 production.
Thyroiditis
Association of heterogeneity of the thyroid gland with matrix metalloproteinase-3 in rheumatoid arthritis patients with Hashimoto's thyroiditis.
Triple Negative Breast Neoplasms
Zerumbone Suppresses IL-1?-induced Cell Migration and Invasion by Inhibiting IL-8 and MMP-3 Expression in Human Triple-negative Breast Cancer Cells.
Tuberculosis
Early Secretory Antigenic Target-6 Drives Matrix Metalloproteinase-10 Gene Expression and Secretion in Tuberculosis.
Expression kinetics of metalloproteinases and their tissue inhibitors in experimental murine pulmonary tuberculosis.
In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway.
Urinary Bladder Neoplasms
Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma.
Homeobox A10 promotes the proliferation and invasion of bladder cancer cells via regulation of matrix metalloproteinase-3.
Matrix metalloproteinase polymorphisms and bladder cancer risk.
MMP-3 mRNA and MMP-3 and MMP-1 proteins in bladder cancer: a comparison with clinicopathologic features and survival.
Role of MMP-3 and MMP-9 and their haplotypes in risk of bladder cancer in North Indian cohort.
The biochemical value of urinary metalloproteinases 3 and 9 in diagnosis and prognosis of bladder cancer in Egypt.
Urinary Incontinence
[MMP-1 and MMP-3 gene encoding polymorphism and the risk of the development of pelvic organ prolapse and stress urinary incontinence].
Uterine Cervical Neoplasms
Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells.
Uterine Hemorrhage
Expression of matrix metalloproteinase-26 and tissue inhibitor of matrix metalloproteinase-3 and -4 in endometrium throughout the normal menstrual cycle and alteration in users of levonorgestrel implants who experience irregular uterine bleeding.
Uveitis
MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment.
Vaccinia
APMA (4-aminophenylmercuric acetate) activation of stromelysin-1 involves protein interactions in addition to those with cysteine-75 in the propeptide.
Varicose Ulcer
Induction of MMP-1, MMP-3 and TIMP-1 in normal dermal fibroblasts by chronic venous leg ulcer wound fluid*.
Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds.
Varicose Veins
Comparison of extracellular matrix in skin and saphenous veins from patients with varicose veins: does the skin reflect venous matrix changes?
Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3.
Matrix metalloproteinases in the vein wall.
Pathogenesis of primary varicose veins.
Polymorphism of matrix metalloproteinase genes (MMP1 and MMP3) in patients with varicose veins.
Vascular Calcification
Impact of ENPP1 and MMP3 gene polymorphisms on aortic calcification in patients with type 2 diabetes in a Korean population.
Vascular Diseases
Matrix metalloproteinase-3 genotype contributes to age-related aortic stiffening through modulation of gene and protein expression.
Vascular System Injuries
Role of the fibrinolytic and matrix metalloproteinase systems in arterial neointima formation after vascular injury.
Vasculitis
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
The significance of metalloproteinase 3 (MMP-3), chemokine CXC ligand 13 (CXCL-13) and complement component C5a in different stages of ANCA associated vasculitis.
Vasospasm, Intracranial
Differential regulation of matrix-metalloproteinases and their tissue inhibitors in patients with aneurysmal subarachnoid hemorrhage.
Venous Thrombosis
MMP-3-1612 polymorphism--a risk factor for deep venous thrombosis formation.
Ventricular Dysfunction, Left
Circulating Stromelysin-1 (MMP-3): a novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarction.
Matrix Metalloproteinase 3 Gene Polymorphism and Its Level Predict Morbidity After Acute Myocardial Infarction.
Virus Diseases
Association of genetic polymorphisms with histological grading of necroinflammation, staging of fibrosis, and liver function in mexicans with chronic hepatitis C virus infection.
Vitelliform Macular Dystrophy
Age-related macular degeneration: a perspective on genetic studies.
Vitreous Detachment
[Posterior vitreous detachment induced by intravitreal injection of the combination of chondroitinase ABC and matrix metalloproteinase-3.]